最新刊期
期 8 ， 2021
- 摘要：Traditional Chinese medicine (TCM) connotation and clinical significance of gut-lung axis was discussed based on the combination of TCM theory and modern medical research. The anatomical position of intestine and lung is close, with diaphragm as the boundary. Therefore, intestine and lung have the functions of regulating body fluid, sharing nutrition and nourishment, and participating in immune protection. Intestinal flora has certain influence on the lung physiology and pathology. Regulating intestinal flora can facilitate the treatment of multiple lung diseases and affect the lung and gut immunity. Although the material basis and signaling pathways of body fluid metabolism between the lung and intestine are not clear yet, the modern intellectual framework of gut-lung axis, which has profound clinical significance, will eventually be formed with the development of modern science and technology.关键词：gut-lung axis;exterior-interior correlation between lung and large intestine;intestinal flora
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发布时间：2022-08-03 - 摘要：ObjectiveTo explore the targets and components of Tenghuang Jiangu Tablet (THJGT) in treating knee osteoarthritis.MethodsThe active ingredients and targets of THJGT were collected and identified from TCMSP database. The targets of THJGT in treating knee osteoarthritis were mined by 8 databases including UniProt KB network platform. The enrichment analysis of gene ontology (GO) and Kyoto encyclopedia of genes and genomes (KEGG) were used to analyze the mechanism of THJGT in the treatment of knee osteoarthritis.ResultsA total of 85 effective ingredients, such as naringin, licorice chalcone A, mangiferin, aloe emodin, dehydrated icariin, stamen isoflavone, 8-methaduraxine, etc., were obtained from THJGT, which acted on a total of 121 target proteins including AKT1, MAPK3, CASP3, STAT3, EGFR, VEGFA, EGF, etc. THJGT affected the lipopolysaccharide response, bacterial molecular cell response, the regulation of apoptosis signal pathway, the regulation of cytokine production, the response to oxidative stress and other biological processes, and regulated the AGE-RAGE signal pathway, C-type lectin receptor signal pathway, TNF signal pathway and IL-17 signal pathway. The results of molecular docking showed that the two active components, glycyrrhizin-A and naringin, could effectively bind to the protein target AKT1 and IL-6 respectively.ConclusionTHJGT could play a role in treating knee osteoarthritis through multiple active ingredients, multiple targets and multiple pathways.关键词：knee osteoarthritis;Tenghuang Jiangu Tablets;network pharmacology;signal pathway;molecular docking
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发布时间：2022-08-03 -
Literature mining and clinical verification of sensitized acupoints in knee osteoarthritis treatment
摘要：ObjectiveTo analyze the main sensitized acupoints and the ways of acupoint sensitization in the treatment of knee osteoarthritis (KOA), and to verify the correlation between acupoint sensitization and KOA severity and inflammatory factors through clinical research.MethodsLiteratures of PubMed, Embase (OvidSP), Cochrane Library, CNKI and other domestic and foreign databases from the establishment of the database to December 30, 2019 were searched, and literatures related to KOA sensitized acupoints were screened out. Bibliometrics was adopted to count the frequency of KOA sensitized acupoints, sensitization types and sensitization methods to analyze the rules involved. Besides, 104 KOA cases were selected successively from our previous cohort study. Near-infrared imaging and related software tools were used to collect the temperature changes of main sensitized acupoint areas. Simple linear and multiple linear regression were used to analyze the correlation between regional cutaneous temperature of sensitized acupoints and the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) scores, tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6) and interleukin-1β (IL-1β) levels.Results①Finally 73 literatures were included. ②The sensitized acupoints involved in the literature were Yanglingquan (GB34), Xuehai (SP10), Dubi (ST35), Neixiyan (EX-LE4), and Yinlingquan (SP9) according to the frequency from high to low. Yanglingquan (GB34) ranked the first in frequency, whose primary sensitization method was heat sensitization. ③Simple linear regression showed that the regional temperature of Yanglingquan (GB34) was positively correlated with WOMAC scores (r=0. 191, P<0.05) and plasma IL-1β level (r=0. 212, P<0.05), but not with plasma TNF-α level (r=0. 100, P >0.05) and IL-6 level (r=0.121, P>0.05). ④Enter method of multiple linear regression showed that plasma IL-1β level was a risk factor affecting the regional temperature of Yanglingquan (GB34) [β= 0.056 (0.001, 0.111), P<0.05].ConclusionThere is obvious acupoint sensitization in KOA treatment, and the regional temperature of sensitized acupoints is positively correlated with the severity of KOA.关键词：knee osteoarthritis;acupoint sensitization;Yanglingquan (GB34);regional acupoint temperature;IL-1β;inflammatory factor- 7
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发布时间：2022-08-03 - 摘要：Postoperative intestinal adhesion is one of the most common complications after abdominal surgery, which cannot be completely avoided even with the popularization of minimally invasive surgical technology. Traditional Chinese medicine (TCM) has advantages in treating postoperative intestinal adhesion, which can significantly alleviate the symptoms and signs of patients and improve their quality of life. Due to the particularity of surgical diseases, the traditional theoretical system of zang-fu syndrome differentiation cannot be well applied to TCM syndrome differentiation of surgical diseases. Therefore, inspired by the integration of Chinese and Western medicine, the discussion on the pathogenesis, syndrome differentiation and treatment of postoperative intestinal adhesion is conducted based on the eight-principle syndrome differentiation system (with deficiency-excess syndrome differentiation as the focus) together with the considerations on the pathophysiological characteristics and clinical manifestations of postoperative intestinal adhesion. Attached is a proven case.关键词：postoperative intestinal adhesion;abdominal pain;syndrome differentiation and treatment;eight-principle syndrome differentiation;deficiency-excess syndrome differentiation;pathophysiology;integration of Chinese and Western medicine
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发布时间：2022-08-03 - 摘要：This paper introduced the clinical experience of treating knee osteoarthritis with rattan drugs in Shi’s traumatology. Knee osteoarthritis is a chronic disease with difficulty to heal, and it is difficult to get rid of the causes of chronic diseases deep into the meridians only with conventional drugs. On the other hand, rattan drugs have the advantages of activating promoting benefit, dissipating bind and dredging collaterals, and introducing all kinds of Chinese medicines directly to the disease sites. Shi’s traumatology is often based on the theory of "The overall dialectical" and "qi-blood-phlegm -stasis theory" , combined with rattan drugs to treat the chronic knee osteoarthritis.And one proven case is presented.关键词：knee osteoarthritis;Shi’s traumatology;rattan drugs;clinical experience
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发布时间：2022-08-03 - 摘要：This article aims to introduce professor Shi Qi’s clinical experience in treating knee osteoarthritis from three stages. Professor Shi suggests that knee osteoarthritis can be differentiated into three stages: acute attack stage, acute remission stage and chronic duration stage. During treatment, while taking traditional Chinese medicine (TCM) oral decoctions according to syndrome differentiation in different stages, TCM external treatment methods such as hot medicated compress therapy, Chinese medicine fumigation and externally used paste can also be selected accordingly, supplemented by three steps and nine methods of knee manipulation to regulate sinews, press and move bones and muscles and dredge collaterals for the purpose of restoring the balance of sinews and bones. Professor Shi also advocates the intervention concept of integration of prevention, treatment and nourishment.关键词：knee osteoarthritis;treatment by stages;internal intake of traditional Chinese medicine;external treatment of traditional Chinese medicine;three steps and nine methods of knee manipulation;preventive treatment of disease;famous doctor’s experience
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发布时间：2022-08-03 - 摘要：Professor Wu Shan’s clinical experience in the diagnosis and treatment of greater occipital neuralgia with Lin’s fixed-point rotating and pulling method as the main method was introduced in this article. Professor Wu believes that the mechanical imbalance of bones, muscles and tendons, and wind-cold-dampness blocking channels and collaterals are the main etiology and pathogenesis of the disease. In clinical diagnosis and treatment, Professor Wu pays attention to accurate positioning before manipulation; When manipulating, Professor Wu regulates the tendons and muscles first and then use explosive force to set bones. After manipulation, Professor Wu uses traditional Chinese medicine hot compress bag together with functional exercise. One proven case was provided.关键词：greater occipital neuralgia;Lin’s fixed-point rotating and pulling method;etiology and pathogenesis;bone setting;tuina massage;mechanics of bones and tendons;famous doctor’s experience
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发布时间：2022-08-03 - 摘要：To introduce an effective case of Professor Weng Weiliang in treating ischemic cardiomyopathy with severe left ventricular dysfunction after coronary stent implantation. It is considered that the main pathogenesis is deficiency of healthy qi and excess of pathogenic factors, mixture of deficiency and excess, especially the blood stasis; the treatment idea is mainly to replenish qi and activate blood, meanwhile according to the change of the disease, or warm yang, or promote urination, or nourish yin, and the specific prescriptions include Coronary Heart Disease No. 6 Recipe, Sishen Yangyin Decoction, Shengmai Decoction, etc.关键词：coronary stenosis;stent implantation;ischemic cardiomyopathy;famous doctor’s experience;Weng Weiliang
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发布时间：2022-08-03 - 摘要：Through tracing the source of medicine, differentiating between phlegm and coldness, analyzing decoction, comparing similar decoctions, this paper promoted a differentiation and analysis of "gallbladder coldness" , which is the major disease treated by Wendan Decoction. This decoction was once thought to be derived from three ancient books as the main treatment of "gallbladder coldness" . However, most textbooks of "formulas of Chinese medicine" suggested that Wendan Decoction should be mainly used to treat "disharmony between gallbladder and stomach, syndrome of phlegm-heat attacking internally" . It seemed that the function of the medicine had turned to the opposite, from "coldness" to "heat" . This paper also revealed that ginger dosage had increased during the development of this decoction. Therefore, Wendan Decoction should be regarded as the major decoction for treating "gallbladder phlegm" , a syndrome of stomach depression and gallbladder stagnation, stagnation of endogenous retention of phlegm.关键词：Wendan Decoction;gallbladder coldness;gallbladder phlegm;differentiation and analysis
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发布时间：2022-08-03 - 摘要：This paper discusses the ancient and modern application and related research of Gegen Decoction, and summarizes the law of its application. It is considered that the efficacy of Puerariae Lobatae Radix obviously affects the application of the whole prescription, and in the use of Gegen Decoction we should pay close attention to "two words" , that is, Biao (exterior)and Qiang (strong) and "four meridians" , that is, small intestine meridian of hand-taiyang, bladder meridian of foot-taiyang,large intestine meridian of hand-yangming and stomach meridian of foot-yangming.关键词：Gegen Decoction;classical prescription;origin;meridian circulation
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发布时间：2022-08-03 - 摘要：ObjectiveTo evaluate the clinical effect of traditional Chinese herbal medicine (TCHM) treatment based on syndrome differentiation (oral administration and external application of TCHM based on syndrome differentiation with "Yiqi Huayu Bushen method" ) combined with sacral canal block on lumbar disc herniation.MethodsA total of 430 cases collected from 5 sub-centers were randomly divided into treatment group (n=215) and control group (n=215). The treatment group was given oral administration and external application of TCHM based on syndrome differentiation with "Yiqi Huayu Bushen method" combined with sacral canal block technique, while the control group was administered with conventional western medicine treatment. The course of treatment lasted 2 weeks, and each case was followed up for 4 weeks to observe the safety of medication, and compare the changes of local pain visual analogue scale (VAS) score, Japanese Orthopedic Society (JOA) lumbar score and Oswestry dysfunction index (ODI) score before and after treatment.Results①During the trial, there were 5 drop-out cases in the treatment group and 5 drop-out cases in the control group. Finally, 420 cases completed the trial, including 210 cases in the treatment group and 210 cases in the control group. ②According to the intra-group comparisons before treatment and at different time points after treatment, the differences in the VAS scores of local pain were statistically significant in both groups (P<0.05), and the VAS scores gradually decreased at different time points after treatment. The VAS score of local pain in the treatment group was lower than that in the control group after 1 week and 2 weeks of treatment respectively, and the differences were statistically significant (P<0.05). There was no significant difference in VAS score of local pain between groups at 4 weeks of follow-ups (P>0.05), and the non-inferiority test was qualified. ③According to the intra-group comparisons before treatment and at different time points after treatment, the differences in the JOA lumbar scores were statistically significant in both groups (P<0.05), and the JOA lumbar scores gradually increased at different time points after treatment. The JOA lumbar score in the treatment group was lower than that in the control group after 1 week and 2 weeks of treatment, and the differences were statistically significant (P<0.05). There was no significant difference in JOA lumbar score between groups at 4 weeks of follow-ups (P>0.05), and the non-inferiority test was qualified. ④According to the intra-group comparisons before treatment and at different time points after treatment, the differences in the ODI scores were statistically significant in both groups (P<0.05), and the ODI scores gradually decreased at different time points after treatment. The ODI scores in the treatment group were lower than those in the control group after 2 weeks of treatment, and the difference was statistically significant (P<0.05). There was no significant difference in ODI scores between groups at 4 weeks of follow-ups (P>0.05). ⑤There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05).ConclusionCompared with conventional western medicine treatment, oral administration and external application of TCHM based on syndrome differentiation with "Yiqi Huayu Bushen method" combined with sacral canal block technique has the advantage of early therapeutic effect, which can relieve pain symptoms and lumbar dysfunction of patients more quickly. In the follow-up period (mid-term), the therapeutic effect of treatment group is not inferior to that of the control group.关键词：lumbar disc herniation;traditional Chinese herbal medicine;treatment based on syndrome differentiation;sacral epidural drug injection therapy;conservative treatment;multicenter clinical trial
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发布时间：2022-08-03 - 摘要：ObjectiveTo investigate the effect of massage manipulation on joint stiffness of patients with knee osteoarthritis based on the "spine-pelvis-knee" holistic diagnosis and treatment pattern.MethodsEighty patients with knee osteoarthritis were randomly divided into treatment group (n=40) and control group (n=40). The control group was administered with local massage manipulation, while the treatment group was administered with massage manipulation based on the "spine-pelvis-knee" holistic diagnosis and treatment pattern. The two groups were treated continuously for one course of treatment, and the changes of the Western Ontario MacMaster (WOMAC) stiffness score, joint range of motion, visual analogue scale (VAS) pain score and the incidence of lumbar and pelvic symptoms were compared.Results①According to the intra-group comparison before and after treatment, there were significant differences in WOMAC stiffness scores, joint range of motion, and VAS scores in both groups (P<0.05); After treatment, the WOMAC stiffness score in the treatment group was lower than that in the control group (P<0.05). ②After treatment, the proportion of patients with symptoms of lumbar vertebra or pelvis in the two groups decreased (P<0.05), and the proportion in the treatment group decreased more significantly than that in the control group (P<0.05).ConclusionMassage manipulation based on the "spine-pelvis-knee" holistic diagnosis and treatment pattern is effective in treating knee osteoarthritis as it can improve the lower limb alignment, reduce the stiffness and pain of knee joint, and increase the range of joint flexion and extension.关键词：knee osteoarthritis;massage;holistic concept;lower limb alignment
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发布时间：2022-08-03 - 摘要：ObjectiveTo observe and compare the clinical effects of small splint fixation, plaster external fixation and open reduction and plate internal fixation for treatment of distal radius extension fractures in the middle-aged and elderly, and analyze the related factors affecting the therapeutic effect of small splint fixation.MethodsA total of 135 middle-aged and elderly patients with distal radius extension fractures were randomly divided into splint group, plaster group and operation group, with 45 cases in each group. The splint group was administered with small splint fixation, the plaster group was administered with plaster external fixation, and the operation group was administered with open reduction and plate internal fixation. X-ray examination was performed on the affected limb at the first week, the second week and the sixth week after treatment for the determination of whether to remove the fixation device, and the patients were followed up for 3 months after treatment. The changes of palmar tilt (PT) angle, ulnar deviation (UD) angle, radial shortening (RS) height and Cooney wrist score were observed and compared under X-ray, and the related factors affecting the therapeutic effect of splint group were analyzed by multiple linear regression method.Results①During the trial, there was no drop out case in the three groups. ②According to the intra-group comparison before treatment and 6 weeks after treatment, there were significant differences in PT angle, UD angle and RS height in all groups (P<0.05). The inter-group comparison after 6 weeks of treatment showed that the improvement of PT angle and RS height in the operation group was better than that in the splint group and the plaster group (P< 0.05). ③After 3 months of treatment, the excellent and good rate of Cooney wrist score in splint group, plaster group and operation group was 91.1%, 75.6% and 93.3% respectively; The excellent and good rate of Cooney wrist score in the splint group and operation group was significantly better than that in plaster group (P<0.05). ④The height of radial shortening before treatment was correlated with the excellent and good rate of Cooney wrist score at 3 months after treatment (r=-0.584, P=0.002), i.e., the height of radial shortening before treatment had a greater impact on the therapeutic effect of patients in the splint group.ConclusionsThe three fixation methods can restore the palmar tilt angle, ulnar deviation angle and radius shortening height of distal radius extension fractures. Small splint fixation and open reduction and plate internal fixation have the same therapeutic effect on restoring wrist joint function in the treatment of distal radius extension fractures, which is superior to the therapeutic effect of plaster fixation. The height of radial shortening before treatment has a great influence on the therapeutic effect of small splint fixation.关键词：small splint fixation;plaster fixation;open reduction and plate internal fixation;distal radius fractures;extension type;clinical efficacy;radial head height
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发布时间：2022-08-03 - 摘要：ObjectiveTo investigate the clinical effect of Xiaoxuming Decoction combined with conventional therapy on post-stroke upper limb spasticity (wind-phlegm obstructing collaterals syndrome).MethodsNinety patients with post-stroke upper limb spasticity (wind-phlegm obstructing collaterals syndrome) were randomly divided into control group (n=45) and test group (n=45). The control group was administered with conventional secondary prophylaxis combined with rehabilitation training, while the test group was administered with Xiaoxuming Decoction besides the treatment measures of the control group. The treatment duration was 12 weeks. The pre- and post-treatment clinical indicators, including surface electromyography (EMG) signals, Modified Ashworth Scale (MAS) scores, Fugl-Meyer Assessment (FMA) scores and Modified Barthel Index (MBI) scores, were compared between the two groups, and the safety was evaluated.Results①There were 3 drop-out cases in the test group and 1 drop-out case in the control group, and 86 cases completed the trial, including 42 cases in the test group and 44 cases in the control group. ②Intra-group comparison before and after treatment showed that the integrated EMG (IEMG) and root mean square (RMS) values of biceps and triceps decreased in both groups (P<0.05); After treatment, RMS values of biceps and triceps were significantly different between the two groups (P<0.05). ③According to the intra- group comparison of the two groups before and after treatment, the MAS scores of the two groups improved (P<0.05); After treatment, there was a significant difference in the MAS scores between the two groups (P<0.05). ④The scores of FMA and MBI increased after 6 weeks of treatment and after treatment in both groups compared to those before treatment (P<0.05); According to the inter-group comparison after 6 weeks of treatment, the difference in scores of MBI was significant between the groups (P<0.05); After treatment, the scores of FMA and MBI were significantly different between the two groups (P<0.05). ⑤During the trial, no significant adverse reactions were observed in both groups.ConclusionThe combined use of Xiaoxuming Decoction and conventional therapy is effective in treating post-stroke upper limb spasticity (wind-phlegm obstructing collaterals syndrome) by effectively reducing upper limb muscle tension, relieving post-stroke spasticity, and improving daily living ability and motor function.关键词：stroke;cerebral apoplexy;myospasm;Xiaoxuming Decoction;surface electromyography;traditional Chinese herbal medicine research
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发布时间：2022-08-03 - 摘要：ObjectiveTo observe the effect of Tongdu Tiaoshen massage (massage for promoting the circulation of the governor vessel and regulating the spirit) on pediatric tic disorders (TD).MethodsA total of 124 children with TD were randomly divided into control group (n=62) and treatment group (n=62). The control group was administered with comprehensive behavioral interventions combined with traditional Chinese medicine (TCM), while the treatment group was additionally administered with Tongdu Tiaoshen massage besides the treatment measures of the control group. The course of treatment in both groups lasted 12 weeks. The clinical effect was observed and the changes in the Yale Global Tic Severity Scale (YGTSS) scores were compared.Results①Finally 121 cases completed the trail, including 61 cases in the treatment group and 60 cases in the control group. ②The total effective rate was 96.7% in the treatment group and 80.0% in the control group; The clinical effect of the treatment group was significantly better than that of the control group (P<0.05). ③The intra-group comparison before and after treatment showed that there were significant differences in YGTSS scores in both groups (P<0.05); After treatment, the YGTSS score of the treatment group was significantly lower than that of the control group (P<0.05).ConclusionTongdu Tiaoshen massage has a good clinical effect on pediatric tic disorders, and patients have high compliance with the treatment as Tongdu Tiaoshen massage meets the needs of parent-child interaction.关键词：tic disorder;Tourette syndrome;children;traditional Chinese medicine massage;Tongdu Tiaoshen;interactive therapy;clinical research
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发布时间：2022-08-03 - 摘要：ObjectiveTo observe the clinical effect of Pinggan Huotan Decoction on insomnia with hypomnesia of liver depression and phlegm heat syndrome.MethodsTotally 72 patients with insomnia and hypomnesia of liver depression and phlegm heat syndrome were randomly divided into treatment group (n=36) and control group (n=36). The control group was administered with Shugan Jieyu Capsule, while the treatment group was administered with Pinggan Huotan Decoction. The course of treatment in both groups was 8 weeks. We observed the clinical efficacy, and compared the changes of TCM syndrome scores, modified Spiegel criteria scores, and P300 latency and amplitude in event-related potential (ERP) detection.Results①During the clinical trial, there were 3 drop-out cases in the control group and 2 drop-out cases in the treatment group, and 67 cases finally completed the trail, including 33 cases in the control group and 34 cases in the treatment group. ②The total effective rates of the treatment group and the control group were 88.23% and 63.64%, respectively. The clinical effect of the treatment group was better than that of the control group (P<0.05). ③With the prolongation of treatment time, TCM syndrome scores and modified Spiegel criteria scores of both groups gradually decreased (P<0.001); According to the inter-group comparison after 4 weeks, 6 weeks and 8 weeks of treatment, the TCM syndrome scores and modified Spiegel criteria scores of the treatment group were lower than those of the control group (P<0.05). ④According to the intra-group comparison before and after treatment, the latency of P300 became shorter and the amplitude increased in the treatment group after treatment (P<0.05), and the latency of P300 became shorter in the control group after treatment (P<0.05); According to the inter-group comparison after treatment, there were significant differences in latency and amplitude of P300 between the two groups (P<0.05).ConclusionPinggan Huotan Decoction is effective in treating insomnia with hypomnesis of liver depression and phlegm heat syndrome as it can significantly improve patients’ symptoms of insomnia, hypomnesis and TCM syndromes.关键词：insomnia;sleeplessness;hypomnesis;Pinggan Huotan Decoction;event-related potential
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发布时间：2022-08-03 - 摘要：ObjectiveTo develop an HPLC wavelength switching method for determining the contents of (R,S) -goitrin, chlorogenic acid, albiflorin, forsythoside A, irisflorentin in Yinban Prescription.MethodsThe separation was performed on an Agilent InfinityLab Poroshell 120 SB-C18 (3.0 mm×150 mm, 2.7 μm) at 35 ℃ using a gradient elution with 0.1% phosphoric acid acetonitrile and 0.1% phosphoric acid water. The flow rate was 0.8 mL/min and the detection wavelength was set at 240 nm within 0-4 min, 325 nm within 4-6.5 min, 230 nm within 6.5-9 min, 328 nm within 9-21 min, 265 nm within 21-24 min.Results(R,S)-goitrin, chlorogenic acid, albiflorin, forsythoside A, risflorentin had a good linear relationship with the peak area in the range of 0.145-18.560 (r=1) , 3.566-228.200 (r=1) , 2.281-292.000 (r=1) , 6.312-808.000 (r=1) , 0.238-30.480 (r=1) g, respectively. The average recoveries were 97.86%, 102.09%, 99.06%, 98.63%, 101.51%, with RSD 1.90%, 1.43%, 1.62%, 1.40%, 1.94% (n=9), respectively.ConclusionThe HPLC wavelength switching method is accurate, reliable and reproducible for quality evaluation of Yinban Prescription.关键词：Yinban Prescription;(R,S)-goitrin;chlorogenic acid;albiflorin;forsythoside A;irisflorentin;HPLC;content determination
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发布时间：2022-08-03 - 摘要：ObjectiveTo explore the effects of different compatibility ratios of drug pair of Bupleuri Radix and Ginseng Radix et Rhizoma on glucose and lipid metabolism in non-alcoholic fatty liver disease (NAFLD) rats.MethodsForty-eight Wistar rats were randomly divided into a normal group (group C) with 8 rats and a modeling group with 40 rats. The rats in Group C was given normal feed and 0.9% NaCl solution by gavage, and the rats in the modeling group was given high-fat and high-sugar feed and 0.9% NaCl solution by gavage. After the model was successfully built, the model rats were randomly divided into model group (group M), drug pair of Bupleuri Radix and Ginseng Radix et Rhizoma 1∶1 group (CR 1∶1 group), drug pair of Bupleuri Radix and Ginseng Radix et Rhizoma 1∶2.5 group (CR 1∶2.5 group), drug pair of Bupleuri Radix and Ginseng Radix et Rhizoma 2.5∶1 group (CR 2.5∶1 group) and obeticholic acid group (OB group), 8 rats in each group. Each medication group was given high-fat and high-sugar feed and corresponding drugs by gavage. After the intervention, the body weight and liver wet weight of the rats were weighed, the pathological staining was observed, and the liver function, blood lipid, fasting blood glucose (FBG), insulin sensitivity index (ISI) and insulin resistance index (HOMA-IR) were measured.ResultsCompared with the group C, alanine aminotransferase (ALT), aspartate aminotransferase (AST), total cholesterol (TC), triacylglycerol (TG), FBG, insulin content (FINS) and HOMA-IR increased, while insulin sensitivity index (ISI) level decreased, and liver steatosis and inflammation aggravated in group M of rats. Compared with group M, the glucose metabolism and lipid metabolism of each medication group were improved to a certain extent. Comparison between medication groups, the body weight, liver wet weight, TC, ALT, AST, FBG, FINS, HOMA-IR, and steatosis and inflammation scores of the CR 2.5∶1 group decreased significantly compared with the other two groups; the increase in ISI level is also the most significant; the drug effect is the best when the proportion of Bupleuri Radix to Ginseng Radix et Rhizoma is 2.5∶1. Compared with the OB group, the body mass level of CR 2.5∶1 group decreased more significantly, while the liver wet weight, TC, AST, and the improvement of FBG, ISI and inflammation score were not as significant as those of OB group.ConclusionThe drug pair of Bupleuri Radix and Ginseng Radix et Rhizoma can improve the glucose and lipid metabolism of NAFLD rats, and the best compatibility ratio of Bupleuri Radix to Ginseng Radix et Rhizoma is 2.5∶1.关键词：Bupleuri Radix;Ginseng Radix et Rhizoma;model rats;non-alcoholic fatty liver disease;glucose metabolism;lipid metabolism;research on traditional Chinese medicine
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发布时间：2022-08-03 - 摘要：ObjectiveTo study effect of Shengqing Capsule on nuclear receptors and ATP Binding Cassette (ABC) Transporters in cholesterol gallstone mice.Methods30 C57BL/6J mice were randomly divided into normal group, model group and Shengqing Capsule group, with 10 mice in each group. The cholesterol gallstone model group was developed by feeding high-fat lithogenic diet for 7 consecutive weeks, while the normal group was fed with normal diet. The Shengqing Capsule group was administered drug (0.355 g/kg·d) by gavage when modeling, while the normal group and model group were administered the same amount of normal saline by gavage. After modeling, the stone formation rate in each group was observed. The gross morphological changes of gallbladder and liver were assessed by the H&E staining, the levels of Triglycerides (TG) , total cholesterol (TC) , and total bile acids (TBA) in serum and liver were measured by GPO-PAP. Real time-PCR and western blot were performed to detect the mRNA and protein expression levels of LXR-α, FXR, ABCA1, ABCG5, ABCG8 in the liver respectively.Results①Compared with the normal group, the stone formation rate increased (P<0.05) , and the gross morphology of gallbladder and liver was damaged in various degrees in the model group. The stone formation rate reduced (P<0.05) , the gross morphology of gallbladder and liver was improved in various degrees of the Shengqing Capsule group compared with those of the model group. ②Compared with the normal group, the levels of TC and TG in serum and liver increased, but the level of TBA in liver decreased, the mRNA and protein expressions of LXR-α, FXR, ABCA1, ABCG5, ABCG8 in liver increased in the model group (P<0.05, P<0.01) . Compared with the model group, the leuel of TC and TG in serum and liver significantly decreased, the mRNA of LXR-α, FXR, ABCG5 and ABCGB decreasecl, and the protein expression of ABCA1 decreased in the Shenqing Capsule group (P<0.05, P<0.01)ConclusionShengqing Capsule may down-regulate LXR-α/FXR and its direct gene ATP-binding cassette transports to reduce the stone formation rate in C57 mice.关键词：shengqing Capsule;cholesterol gallstone;cholesterol-bile acid metabolic chain;nuclear receptors LXR-α/FXR;the ATP binding cassette transporters
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发布时间：2022-08-03 - 摘要：ObjectiveTo establish the quality standard for tablet of Selaginellae Herba total flavones.MethodsThin layer chromatography (TLC) was used for qualitative determination. Ultraviolet spectrophotometry (UV) was used to determine the content of Selaginellae Herba total flavones and high performance liquid chromatography (HPLC) to determine the content of amentoflavone in Selaginellae Herba total flavones tablet. The weight variation and disintegration time limited in the inspection items were controlled.ResultsThe TLC spots were clear with strong specificify. Selaginellae Herba total flavones showed a good linear relationship at the range of 1.571-11.781 μg/mL (r=0.999 8). The average recovery was 98.25% , and RSD was 1.02% . Amentoflavone showed a good linear relationship at the range of 6.545-327.246 μg/mL (r=1.000 0). The average recovery was 96.03% , and RSD was 0.49% . Weight variation and disintegration time limited were up to specification.ConclusionThe established method is rapid, accurate, reproducible with a strong specificify.关键词：tablet ofselaginellae Herba total flavones;quality standard;amentoflavone;HPLC;UV
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发布时间：2022-08-03 - 摘要：Huangqi Decoction (the dosage of Astragali Radix and Glycyrrhizae Radix et Rhizoma is 6∶1) was first published in Taiping Huimin Heji Ju Fang (Prescripton of Peaceful Benevolent Dispensary). It has the effect of tonifying qi, blood and producing essence, and is mainly used to treat the symptoms of qi and blood deficiency. The clinical application and basic research of Huangqi Decoction compound mainly involved chronic liver disease and diabetes mellitus type 2. The active ingredients of Astragali Radix and Glycyrrhizae Radix et Rhizoma in Huangqi Decoction are widely used in cardiovascular disease, diabetic nephropathy, respiratory diseases and immune system diseases.关键词：Huangqi Decoction;Astragali Radix;Glycyrrhizae Radix et Rhizoma;research progress;review
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发布时间：2022-08-03 - 摘要：This article reviewed the research progress on clinical heterogeneity of Parkinson’s disease (PD) in traditional Chinese medicine and western medicine. It summarized the characteristic symptoms of PD patients with different clinical subtypes and corresponding neuropathological basis. Meanwhile, the internal relationship between TCM syndrome type and clinical heterogeneity of PD was further analyzed. It aimed to combine the clinical classification of PD with western medicine and TCM syndrome differentiation to develop a diagnosis and treatment model with equal emphasis on Chinese and western medicine, which provided a new idea for individualized and precise treatment of PD.关键词：Parkinson’s disease;clinical heterogeneity;cluster analysis;syndrome differentiation;review
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发布时间：2022-08-03
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