最新刊期
期 4 ， 2021
- 摘要：ObjectiveTo interpret the differences in the compilation methods and content of the therapeutic methods part between the old and new editions of Traditional Chinese Medicine (TCM) National Standards for the purpose of promoting the application of the new editions of TCM National Standards.MethodRelational mappings of terms of TCM therapeutic methods and the correspondence tables between terms of therapeutic methods and terms of syndromes in the new and old TCM National Standards were compiled for the statistical analysis and text comparison in respect of the naming standard, the correspondence between terms of therapeutic methods and terms of syndromes, compilation style, classification system, inclusion scope, and definition format.ResultsIn respect of naming standard, the therapeutic methods part of the new editions of TCM National Standards stopped using brackets in terms once used in the old editions. In respect of the correspondence between terms of syndromes and terms of therapeutic methods, the therapeutic methods part of the new editions of TCM National Standards amended and improved terms of syndromes involved in the definition of terms of therapeutic methods, so that the terms of diseases and syndromes matched better with the terms of therapeutic methods. In respect of compilation style, English translation and optional lexical items were added to the therapeutic methods part of the new editions. In respect of inclusion scope, 94 terms were added to the therapeutic methods part of the new editions of TCM National Standards, such as "therapy for preventive treatment of disease" , "emergent purgation to preserve yin-fluid" and "small needle knife therapy" , etc. In respect of classification system, the therapeutic methods part of the new editions of TCM National Standards solved the mix-and-match problem of terms of therapeutic principles, therapeutic methods and therapies in the old editions, and classified them into three separate categories: therapeutic principles, therapeutic methods and therapies. In respect of definition norm, the therapeutic methods part of the new editions of TCM National Standards formulated a unified and standardized definition format for each term.ConclusionCompared with the old editions, the therapeutic methods part of the new editions of TCM National Standards can better satisfy the contemporary demands for the standardization and internationalization of TCM medical informatics in China in respect of naming standard, correspondence between terms of syndromes and terms of therapeutic methods, compilation style, classification system, inclusion scope, and definition format.关键词：TCM National Standards;TCM therapeutic method term;TCM syndrome term;Classification and Codes of Diseases and Patterns of Traditional Chinese Medicine;Clinic Terminology of Traditional Chinese Medical Diagnosis and Treatment;TCM therapeutic method classification system;TCM standardization
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发布时间：2022-08-03 - 摘要：ObjectiveTo explore the mechanism of Astragali Radix in the treatment of Hashimoto’s thyroiditis(HT)based on network pharmacology and molecular docking.MethodsTraditional Chinese medicine system pharmacology database and analysis platform(TCMSP) was used to obtain the chemical components and corresponding targets. The OMIM and GeneCards databases were used to predict and screen disease targets. Cytoscape software was used to construct the component-target network diagram and the protein interaction network diagram for screening out key targets. GO enrichment analysis and KEGG pathway were analyzed by DAVID platform. Finally, autodock vina software was used to verify the core chemical compositions screened in Astragali Radix.ResultsA total of 11 ingredients were screened out from Astragali Radix that mainly belong to flavonoids and saponins. 58 targets were obtained for interaction between Astragali Radix and HT. Astragali Radix plays a role in the treatment of HT by regulating AGE-RAGE signaling pathway, TNF signaling pathway, and IL-17 signaling pathway in the complications of diabetes.ConclusionOur study preliminarily analyzed potential mechanism of Astragali Radix in the treatment of HT. The core ingredients may be jaranol, quercetin and hederagenin.关键词：Astragali Radix;Hashimoto’s thyroiditis;network pharmacology;molecular docking
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发布时间：2022-08-03 - 摘要：ObjectiveThis paper analyzed and summarized the rules of syndrome-treatment-prescription-medicine for traditional Chinese medicine (TCM) treatment of cervical spondylotic myelopathy (CSM) to provide reference for clinical practice.MethodsLiteratures about the treatment of cervical spondylotic myelopathy with oral administration of traditional Chinese medicine were collected and sorted out by searching China National Knowledge Infrastructure (CNKI) database, Wanfang Medical Network database and Chinese Sci & Tech Journals (VIP) database from January 1, 1990 to December 31, 2019. Excel 2010 software was used to calculate the frequency of syndromes, syndrome elements, prescriptions and traditional Chinese herbal medicines (TCHMs), SPSS21.0 software was used to cluster the high-frequency herbal medicines in the database, and SPSS Modeler 18.0 software was used to analyze the association rules of high-frequency TCHMs.Results①Fifty-nine qualified literatures were finally screened out, and 34 TCM syndromes of CSM were obtained after classification, of which liver and kidney deficiency syndrome, qi stagnation and blood stasis syndrome, channel-collateral stasis and obstruction syndrome and qi and blood deficiency syndrome were common syndromes, accounting for 58.82%. ②There were 6 elements manifesting excess disease nature, mainly blood stasis, qi stagnation and dampness obstruction and 4 elements manifesting deficiency disease nature, mainly qi deficiency, blood deficiency and governor channel deficiency. Zang-fu organs involved were mainly kidney and liver. ③There were 84 TCM prescriptions for the treatment of CSM, of which 46 were set prescriptions. The mostly used ones were Buyang Huanwu Decoction, Dihuang Yinzi Decoction, and Shengyu Decoction, etc. According to the classification based on the effects of commonly used prescriptions, it is found that tonifying prescriptions and blood-regulating prescriptions were the most frequently used, accounting for 78.26%. ④There were 165 kinds of TCHMs for the treatment of CSM. The high-frequency TCHMs in turn were Danggui (Radix Angelicae Sinensis), Huangqi (Radix Astragali seu Hedysari), Chuanxiong (Rhizoma Ligustici Chuanxiong), and Honghua (Flos Carthami), etc. Deficiency-tonifying TCHMs and blood circulation-promoting and blood stasis-removing TCHMs were commonly used for the treatment of CSM, of which deficiency-tonifying TCHMs were the most in kinds, accounting for 34.60%. ⑤Cluster analysis showed that TCHMs of high-frequency used in CSM treatment can be divided into three categories: For liver and kidney deficiency syndrome, the optional TCHMs were Niuxi (Radix Achyranthis Bidentatae), Dangshen (Radix Codonopsis), and Shanzhuyu (Fructus Corni), etc.; For qi deficency and blood stasis syndrome, the optional TCHMs were Danggui (Radix Angelicae Sinensis), Huangqi (Radix Astragali seu Hedysari), and Chuanxiong (Rhizoma Ligustici Chuanxiong); For channel-collateral stasis and obstruction syndrome, the optional TCHMs were Baishao (Radix Paeoniae Alba), Dilong (Lumbricus), and Chishao (Radix Paeoniae Rubra), etc. ⑥According to the association rules, 7 core TCHMs and 14 core TCHM combinations were obtained, of which a triangular TCHM group including Huangqi (Radix Astragali seu Hedysari), Danggui (Radix Angelicae Sinensis) and Chuanxiong (Rhizoma Ligustici Chuanxiong) was obtained. It was also found that the core TCHM combinations were mainly deficiency-tonifying TCHMs including Huangqi (Radix Astragali seu Hedysari), Danggui (Radix Angelicae Sinensis) and Baishao (Radix Paeoniae Alba), blood circulation-promoting and blood stasis-removing TCHMs including Chuanxiong (Rhizoma Ligustici Chuanxiong), Taoren (Semen Persicae) and Honghua (Flos Carthami), and liver-calming and wind-stopping TCHM including Dilong(Lumbricus).ConclusionIt is feasible to analyze the rules of TCM treatment of cervical spondylotic myelopathy based on data mining, and the data mining results can provide valuable reference for clinical practice.关键词：cervical spondylotic myelopathy;TCM oral administration;TCM syndrome;TCM treatment;data mining
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发布时间：2022-08-03 - 摘要：The purpase of this paper is to introduce Professor Chen Hongfeng’s clinical experience in the treatment of breast cancer after operation with plaster prescription. It is considered that most of the patients are in the condition of asthenia of healthy qi with stagnation of pathogenic factors. Clinically Professor Chen attaches importance to the syndrome differentiation of the liver, spleen and kidney, and good at the treatment methods of regulating qi and blood, expelling pathogenic factors in the process of supporting healthy qi. And one proven case is presented.关键词：breast cancer;plaster prescription;experience of famous doctors;Chen Hongfeng
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发布时间：2022-08-03 - 摘要：The purpose of this paper is to introduce WuKunlun’s experience in the treatment of malignant tumors with Wu’s Xiaoliu Powder. It is considered that the basic pathogenesis of malignant tumor is the deficiency of vital qi and chronic and repeated obstruction of turbid phlegm, toxin and blood stasis. When treating the disease, the methods such as strengthening the spleen to supplement qi, strengthening healthy qi to consolidate constitution, clear away heat to eliminate dampness, and removing toxin to eliminate accumulation are used, and Wu’s Xiaoliu Powder is prescribed for the disease. Also two proven cases are presented.关键词：malignant tumor;Wu’s Xiaoliu Powder;experience of famous doctors;Wu Kunlun
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发布时间：2022-08-03 - 摘要：Cervical cancer is a common malignant tumor in gynecology, and radiotherapy is one of the main therapeutic methods. Vaginitis caused by radiotherapy is a common complication, which reduces the therapeutic compliance and life quality of the patients to varying degrees. In the treatment of cervical cancer with radioactive vaginitis, Professor Du Huaitang thinks that mixture of heatness, toxin and dampness, and deficiency of both qi and yin are the basic pathogenesis of this disease, and emotional dissatisfaction and stagnation of qi activity are the important influencing factors. Invigorating qi, nourishing yin, clearing away heat, removing toxin and resolving stasis are the basic principles of clinical treatment. Modified Huangqi Plus Danggui Beimu Kushen Pill is applied based on syndrome differenciation, and has obvious effect.关键词：cervical cancer;radioactive vaginitis;Huangqi Plus Danggui Beimu Kushen Pill;famous doctor’s experience;Du Huaitang
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发布时间：2022-08-03 - 摘要：Adenoid hypertrophy is a common and frequently-occurring disease in pediatrics, and its main pathological product is phlegm, so physicians of all ages often treat the disease from the point of view of phlegm. With the development of the theory of activating the spleen, Professor Jiang Zhiyan, through summing up many years of clinical experience, found that the disease is closely related to the spleen, and put forward a new theory of "treating the nose by activating the spleen" , which is used to guide the treatment of adenoid hypertrophy in children, with remarkable clinical effect.关键词：adenoid hypertrophy;treating the nose by activating the spleen;clinical experience;Jiang Zhiyan
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发布时间：2022-08-03 - 摘要：Taking the Shuyuwan in the treatment of "Fengqi Baiji (a variety of diseases caused by pathogenic wind)" in Jingui Yaolue (Synopsis of the Golden Chamber) as an example, some commonness and principles of herbal paste for tumor are discussed based on the prescribing rule of Shuyuwan. It is considered that the herbal paste has the advantage of mild effect and long-lasting drug power, suitable for treating many chronic and weak diseases. Herbal paste is suitable for tumor patients, especially for those who are in a stable period after surgery, radiotherapy and chemotherapy, and are in urgent need of replenishing the healthy qi. And one proven case is presented.关键词：herbal paste;Shuyuwan;tumor;Jingui Yaolue (Synopsis of the Golden Chamber);prescription principle
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发布时间：2022-08-03 - 摘要：The purpase of this paper is to discusse Professor Li Saimei’s clinical experience in the treatment of influenza with Xiao Chaihu Decoction through 4 cases. In clinical diagnosis and treatment of influenza, the key point of dispelling pathogenic factors and the consideration of onset season, regional climatic conditions and syndrome characteristics are stressed for appropriately prescribing Chinese medicines based on Xiao Chaihu Decoction flexibly.关键词：influenza;Xiao Chaihu Decoction;experience of famous doctors;Li Saimei
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发布时间：2022-08-03 - 摘要：ObjectiveTo observe the effect of traditional Chinese medicine (TCM) syndrome differentiation and treatment combined with Icotinib on the overall survival of elderly patients with advanced lung adenocarcinoma with epidermal growth factor receptor (EGFR) mutation.MethodsA total of 74 elderly patients with EGFR-mutant advanced lung adenocarcinoma were randomly divided into treatment group (n=37) and control group (n=37). The control group was administered with Icotinib alone, and the treatment group was additionally administered with TCM decoction based on syndrome differentiation besides Icotinib. The time of disease progression and death after treatment in the two groups was observed, and the median progression-free survival (mPFS) time and median survival (MST) time were calculated.Results①As of July 30th, 2020, 71 patients were finally included after follow-ups for statistical analysis with one drop-out case in the treatment group (n=36) and two drop-out cases in the control group (n=35). ②The mPFS of the treatment group and the control group were 15.40 months and 13.07 months respectively, with significant difference between the two groups (P=0.024, HR=0.575); ③The MST of the treatment group and the control group were 29.90 months and 25.07 months respectively, with significant difference between the two groups (P=0.045, HR=0.580). ④Multivariate analysis showed that combined treatment of traditional Chinese medicine, first-line Icotinib treatment, previous radical resection of lung cancer, and fewer comorbidities were independent protective factors affecting the long-term survival and prognosis of elderly patients with EGFR-mutant advanced lung adenocarcinoma (P<0.05).ConclusionTCM syndrome differentiation and treatment combined with Icotinib can prolong the progression-free survival and overall survival of elderly patients with EGFR-mutant advanced lung adenocarcinoma. The first-line Icotinib treatment stage, radical resection of lung cancer and fewer comorbidities are also conducive to the long-term survival prognosis of elderly patients with advanced lung adenocarcinoma.关键词：lung adenocarcinoma;non-small cell lung cancer;advanced;Icotinib;survival;prognosis;traditional Chinese medicine therapy
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发布时间：2022-08-03 - 摘要：ObjectiveTo observe the effect of Feiliu Xiaoji Formula on adverse reactions of chemotherapy in patients with non-small cell lung cancer of intermingled phlegm and blood stasis syndrome.MethodsTotally 100 cases with non-small cell lung cancer of intermingled phlegm and blood stasis syndrome were randomly divided into treatment group (n=50) and control group (n=50). Both groups were administered with conventional chemotherapy. The control group was treated with anti-vomiting, liver protection and stomach protection as appropriate, while the treatment group was additionally administered with Feiliu Xiaoji Formula besides symptomatic treatment. The course of treatment in both groups was 4 chemotherapy cycles. The clinical effect and incidence of adverse reactions of chemotherapy were observed, and the changes of TCM syndrome scores and Quality of Life Questionnaire Core 30 of EORTC (EORTC QLQ-C30) scores were compared.Results①The total effective rate of the treatment group was 86.00%, which was significantly higher than that of the control group (68.00%) (P<0.05). ②The number of cases of bone marrow suppression (grade 0), digestive tract reaction, alopecia, liver and kidney function damage and peripheral neurotoxicity in the treatment group was more than that in the control group, but the number of cases with above adverse reactions (grade 3-4) in the treatment group was less than that in the control group, and the difference was statistically significant (P<0.05). ③The TCM syndrome scores of both groups decreased after treatment (P<0.05) and the TCM syndrome scores of the treatment lower than the scores of the control group (P< 0.05). ④By comparing the QLQ-C30 scores of the two groups before and after treatment, we found that in both groups the scores of overall quality of life, physical function and emotional function in the functional part increased after treatment (P<0.05), the scores of fatigue, nausea, vomiting, pain, sleep disorder, anorexia, constipation and diarrhea in the symptom part decreased after treatment (P<0.05), and the differences in above mentioned scores were significant between the two groups after treatment (P<0.05).ConclusionFeiliu Xiaoji Formula has synergistic effect with chemotherapy as it can increase the clinical effect on the treatment of non-small cell lung cancer of intermingled phlegm and blood stasis syndrome, improve the quality of life of patients, and reduce adverse reactions of chemotherapy.关键词：non-small cell lung cancer;Feiliu Xiaoji Formula;intermingled phlegm and blood stasis syndrome;chemotherapy;adverse reactions
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发布时间：2022-08-03 - 摘要：ObjectiveTo observe the clinical effect of Huosu Yangwei Syrup combined with SOX chemotherapy regimen in the treatment of advanced gastric cancer (AGC).MethodsA total of 72 AGC patients were randomly divided into treatment group (n=36) and control group (n=36). The control group was administered with SOX chemotherapy regimen alone, while the treatment group was administered with Huosu Yangwei Syrup besides SOX chemotherapy regimen. Both groups were treated for two courses of treatment, with 21 days as one course of treatment. The clinical efficacy and the incidence of adverse reactions were observed. The changes of TCM syndrome scores and the EORTC Core Quality of Life questionnaire (EORTC QLQ-C30) scores were compared.Results①During the trial, there were 2 drop-out cases in the treatment group and 1 drop-out case in the control group. A total of 69 patients finally completed the trail, including 34 cases in the treatment group and 35 cases in the control group. ②The total effective rates of the treatment group and the control group were 64.71% and 14.29% respectively, and the clinical efficacy of the treatwent group was significantly better than that of the control group(P<0.05).③According to the intra-group comparison before and after treatment, the TCM syndrome scores in the treatment group decreased after treatment (P<0.05), but there was no significant difference in the TCM syndrome scores in the control group (P>0.05); According to the inter-group comparison before and after treatment, the differences in the TCM syndrome scores were statistically significant (P<0.05). ④The improvement of fatigue, nausea, vomiting and loss of appetite in the treatment group was better than that in the control group (P<0.05) according to the EORTC QLQ-C30 scores. ⑤The incidence of anemia was 47.06% in the treatment group and 71.43% in the control group, and the incidence of nausea and vomiting was 8.82% in the treatment group and 54.29% in the control group. There was statistically significant difference in the incidence of anemia, nausea and vomiting after chemotherapy between the two groups (P<0.05).ConclusionCompared with the single use of SOX chemotherapy regimen, the combined use of Huosu Yangwei Syrup and Sox regimen in the treatment of advanced gastric cancer shows a more satisfactory result, as it can better improve patients’ clinical symptoms and the quality of life, and reduce the incidence of adverse reactions (anemia, nausea and vomiting) of chemotherapeutic drugs.关键词：gastric cancer;advanced stage;Huosu Yangwei Syrup;tegafur;gimeracil and oteracil potassium
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发布时间：2022-08-03 - 摘要：ObjectiveTo observe the clinical effect of Bazhen Decoction combined with decitabine and CAG chemotherapy in the treatment of elderly acute myeloid leukemia (AML).MethodsTotally 64 elderly AML were randomly divided into control group (n=32) and treatment group (n=32). The control group was administered with decitabine and CAG chemotherapy, while the treatment group was additionally administered with Bazhen Decoction besides the treatment of the control group. Both groups were treated for 2 courses of treatment, and each course lasted 28 days. The clinical effect, the incidence of severe myelosuppression and adverse reactions after chemotherapy were observed, and the changes of TCM syndrome scores were compared.Results①The curative effect of AML: the total effective rate of the treatment group was 50.00%, and that of the control group was 46.88%. There was no significant difference in the curative effect of AML between groups (P>0.05). The curative effect of TCM syndromes: the total effective rate of the treatment group was 62.50%, and that of the control group was 46.88%. The difference of TCM syndrome curative effect between groups was statistically significant (P<0.05). ②According to the intra-group comparison before and after treatment, the scores of bone pain, ecchymosis, dizziness, fatigue, anorexia and fever in the treatment group decreased (P<0.05), while only the scores of bone pain, dizziness, fatigue and anorexia in the control group decreased (P<0.05); After treatment, the scores of ecchymosis, dizziness, fatigue, anorexia and fever in the treatment group were lower than those in the control group (P<0.05). ③The incidences of severe myelosuppression (grade Ⅲ), heart failure, pulmonary infection and gastrointestinal discomfort in the treatment group were lower than those in the control group (P<0.05).ConclusionBazhen Decoction combined with decitabine and CAG chemotherapy regimen is effective in treating elderly AML as Bazhen Decoction is helpful to improve the myelosuppression and the symptoms of deficiency of qi and blood after chemotherapy, and reduce the incidence of adverse reactions of chemotherapy.关键词：acute myeloid leukemia;elderly;Bazhen Decoction;decitabine;CAG regimen;chemotherapy;myelosuppression
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发布时间：2022-08-03 - 摘要：ObjectiveTo observe the clinical effect of Yiqi Congming Decoction combined with western medicine on posterior circulation ischemic vertigo (PCIV) of qi and blood deficiency syndrome in recovery period.MethodsA total of 110 PCIV cases of qi and blood deficiency syndrome in recovery period were randomly divided into treatment group (n=55) and control group (n=55). The control group was administered with aspirin and flunarizine hydrochloride, while the treatment group was administered with Yiqi Congming Decoction besides the conventional treatment of the control group. The course of treatment in both groups was 28 days. The clinical effect was observed, the changes of TCM syndrome scores and transcranial Doppler ultrasound (TCDU) cerebral blood flow indexes (CBFI) were compared, and the safety was evaluated simultaneously.Result①The cured and markedly effective rate of the treatment group and the control group were 94.5% and 50.9%, respectively. The clinical effect of the treatment group was better than that of the control group (P<0.01). ②The TCM symptom scores in both groups decreased after treatment (P<0.01); The TCM syndrome score in the treatment group was lower than that in the control group after treatment (P<0.01). ③The mean blood flow velocity and pulsatility index of left vertebral artery, right vertebral artery and basilar artery in the two groups were significantly different before and after treatment (P<0.01). After treatment, the above indexes were significantly different between the groups (P<0.05). ④The incidence of adverse reactions in the treatment group and the control group were 16.3% and 18.2% respectively, with no significant difference (P>0.05).ConclusionCompared with the single use of western medicine, the combined use of Yiqi Congming Decoction with western medicine has more satisfactory curative effect on PCIV of qi and blood deficiency syndrome in recovery period, and can better improve patients’ clinical symptoms. The mechanism of action may be related to increasing hemoperfusion of vertebrobasilar artery system.关键词：posterior circulation ischemia;vertigo;recovery period;Yiqi Congming Decoction;qi and blood deficiency
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发布时间：2022-08-03 - 摘要：ObjectiveTo evaluate the efficacy of Shugan Hewei Decoction in the treatment of non-erosive gastroesophageal reflux disease(NERD)caused by stagnant heat in the liver and stomach.MethodsTotally 92 patients with NERD were randomly divided into traditional Chinese medicine group(n=46) and Western medicine group(n=46). The traditional Chinese medicine group was treated with Shugan Hewei Decoction and general treatment measures, the Western medicine group with rabeprazole and general treatment measures. The course of treatment in both groups was 8 weeks, and the clinical efficacy and the changes of clinical symptoms, the condition of anxiety and depression were observed.ResultsThe total effective rates of the traditional Chinese medicine group and the Western medicine group were 97.83% and 84.78% respectively, and the clinical effect of the traditional Chinese medicine group was significantly better than that of the Western medicine group(P<0.05). The clinical symptom scores of the two groups decreased significantly after treatment(P<0.05), and there were significant differences between the two groups after treatment(P<0.05). After treatment, the scores of Hamilton Anxiety Scale (HAMA) and Hamilton Depression Scale (HAMD) in the two groups decreased, and there were significant differences between the two groups, suggesting that the improvement of anxiety and depression in the traditional Chinese medicine group was better than that in the Western medicine group.ConclusionShugan Hewei Decoction is superior to rabeprazole in improving clinical symptoms, anxiety and depression in patients with NERD.关键词：non-erosive gastroesophageal reflux diseases(NERD);stagnant heat in the liver and stomach;anxiety;depression;Shugan Hewei Decoction;clinical efficacy
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发布时间：2022-08-03 - 摘要：ObjectiveTo explore the influence of Gangyusan on serum inflammatory factors TNF- α, IL-6, expression of wound regeneration collagen and wound histomorphology in rats after hemorrhoid operation.MethodsSixty SPF SD rats were randomly divided into blank control group, model control group, hemorrhoid lotion group, and low, medium and high dose groups of Gangyusan (n=10). Except for the blank control group, the rats in other groups were injected with 75% glacial acetic acid around the anus to establish hemorrhoid operation model. After successful modeling, the blank control group and the model control group were given fumigation with high pressure sterilization water . The hemorrhoid lotion group and the low, medium and high dose groups of Gangyusan were given corresponding drug fumigation and washing treatment. After treatment, the wound area was measured, the healing rate calculated, and the color and exudation of the wound observed with naked eyes at specific time points (1st, 3rd, 7th and 11th day). Inflammatory reactions such as inflammatory cell infiltration, fibroblasts, granulation tissue proliferation and tissue healing were observed under light microscope. After 10 days of continuous treatment, the histopathology of granulation tissue in each group was compared; the contents of IL-6 and TNF-α in serum and the expression of IL-6 and TNF-α mRNA in wound tissue were detected by enzyme linked immunosorbent assay (ELISA) and fluorescence quantitative assay. The expression levels of COL1 and COL3 in wound tissue were detected by Western blot method and immunohistochemical method.ResultsCompared with the model control group, Gangyusan significantly reduced the expression of IL-6 and TNF- α mRNA in wound tissue and the content of inflammatory factors IL-6 and TNF-α in serum, while the protein expression of COL1 and COL3 in wound tissue increased significantly (P<0.05). Under light microscope, the formation of fresh granulation tissue, neat arrangement of fibroblasts and abundant new capillaries were seen in each treatment group, which were better than those in the model control group.ConclusionGangyusan can reduce the expression of inflammatory factors such as IL-6 and TNF-α in serum and wound tissue of rats, promote the formation of granulation tissue, capillaries and fibroblasts, and promote wound healing after hemorrhoid operation in rats.关键词：Chinese medicine fumigation;Gangyusan;postoperative hemorrhoids;wound healing;inflammatory factors;collagen protein;rats
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发布时间：2022-08-03 - 摘要：ObjectiveTo observe the effect of acupuncture on proteinuria and renal pathology in spontaneous hypertension rats (SHR).MethodsSHR rats were randomly divided into model group, losartan group, Shenshu acupuncture group, Geshu acupuncture group, and Shenshu + Geshu group, with 10 rats in each group, and 10 WKY rats were set as normal group. The losartan group was intragastrically administered with losartan tablets which were dissolved in normal saline, with 30 mg/kg once a day. The acupuncture groups were given with electro-acupuncture intervention according to the corresponding acupoints every other day. The model group was fixed like the acupuncture groups done and without acupuncture. All groups were intervened continuously for 12 weeks. 24-hour urinary protein was detected by biochemical method before intervention and at the end of 4th, 8th and 12th week of intervention. At the end of 12th week, kidney samples were taken to observe the pathological changes of renal ultrastructure by light microscope and electron microscope, and the positive expression area of Klotho protein in renal tissue was detected by immunohistochemistry.ResultsAfter intervention, the 24 h urinary protein in the losartan group and the acupuncture groups were lower than that in the model group(P< 0.05). The renal pathological injury in the losartan group and the acupuncture groups were alleviated in varying degrees, and the expression of Klotho positive area in the losartan group and the acupuncture groups were higher than that in the model group (P<0.05).ConclusionAcupuncture can regulate the expression of Klotho in kidney, reduce proteinuria and renal pathological damage in SHR rats, and delay the progression of hypertensive renal damage.关键词：spontaneous hypertension;rats;acupuncture;Klotho;proteinuria;renal pathology
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发布时间：2022-08-03 - 摘要：ObjectiveTo investigate the effect of Taohongsiwutang (THSWT) on stem cell factor (SCF)/receptor tyrosine kinase (c-kit) pathway and interstitial cells of Cajal (ICC) in rats with ulcerative colitis (UC).MethodsSD rats were randomly divided into sham operation group, model group, THSWT low-dose group (50 mg/kg), medium-dose group (100 mg/kg), high-dose group (200 mg/kg) and sulfasalazine group (positive control group, 0.3 g/kg), with 10 in each group. Except for the sham operation group, the other groups were used to establish UC model with 2, 46-Trinitro benzens a lfonic acid solution(TNBS) solution, after the corresponding drugs were given according to the dosage of each group, the abdominal aorta blood and colon tissue were collected; the pathological changes of colon tissue were detected by hematoxylin eosin (HE) staining, and the pathological scores of rats were evaluated; the ultrastructure of ICC in colon tissue was observed by transmission electron microscope; the level of serum SCF of abdominal aorta was detected by enzyme-linked immunosorbent assay (ELISA); the expression of c-kit positive ICC was detected by immunofluorescence, and the expression of SCF and c-kit proteins was detected by Western blot.ResultsCompared with those in the sham operation group, the rats in the model group had bloody stools, yellow loose stools, listlessness, slow reaction, curling up, and other symptoms, accompanied by slow weight growth, depilation, dark yellow hair color and other characteristics; the colonic tissue showed obvious congestion and blood stasis, and the muscular layer and intestinal mucosa became thinner; the colonic tissue injury score and disease activity index (DAI) score were significantly higher; the number of ICC in colon tissue was less and the structure was vague; the content of SCF in abdominal aorta serum was significantly lower, the fluorescence intensity of c-kit positive ICC was significantly weaken, and the expression of SCF and c-kit protein was significantly lower (P<0.05). Compared with those in the model group, the pathological damage of colon tissue, ICC structure, colonic tissue injury score and DAI score in low, medium and high dose THSWT groups and sulfasalazine group were alleviated in varying degrees; the content of SCF in serum was significantly higher, and the fluorescence intensity of c-kit positive ICC in colon tissue was significantly stronger, the expression of SCF and c-kit protein was significantly higher (P<0.05) with dose-dependency in THSWT groups, while there was no significant difference between THSWT high-dose group and sulfasalazine group (P>0.05).ConclusionTHSWT can alleviate the colon injury in UC rats, which may be achieved by activating SCF/c-kit pathway and protecting the integrity of ICC structure.关键词：Taohongsiwutang;ulcerative colitis;stem cell factor;receptor tyrosine kinase (c-kit);interstitial cells of Cajal;rats
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发布时间：2022-08-03 - 摘要：ObjectiveTo access the anti-inflammatory effect of kidney-supplementing cold-dispelling Zhiwang Decoction (Zhiwang Decoction) combined with methotrexate (MTX) on collagen-induced arthritis (CIA) model rats and the performance of high frequency ultrasound in the evaluation of arthritis in rats.MethodsSD rats were randomly divided into 5 groups: normal group, model group, MTX group, low-dose of Zhiwang Decoction combined group and high-dose of Zhiwang Decoction combined group. Except for the normal group, rats of the other groups were injected in the tail with 50 μL collagen Ⅱ emulsion of 2 mg/mL on the 7th and 14th day of rearing respectively. A total of 21 days of administration began on the 8th day. Toe thickness was measured, arthritis index (AI) was scored and ankle synovitis was evaluated by high-frequency gray-scale ultrasound in rats.ResultsAfter modeling, the toe thickness of each group was significantly thicker than that of the normal group (P<0.01). on the 19th day, the toe thickness of the high-dose combined group was thinner than that of the model group (P<0.05). In terms of AI score, on the 13th day, the AI score of the high-dose combined group was lower than that of the model group (P<0.01). Evaluated by the ultrasound, the synovial thickness of each group was significantly thicker than that of the normal group, the synovium of the low-dose and high-dose groups was significantly thinner than that of the model group, and the synovium of the high-dose group was significantly thinner than that of the MTX group (P<0.05, p < 0.01).ConclusionHigh-frequency ultrasound is suitable for the evaluation of synovitis in CIA model rats, and its sensitivity is better than toe thickness and AI score. High-dose Zhiwang Decoction combined with MTX has a synergistic effect on improving arthritis in CIA rats.关键词：kidney-supplementing cold-dispelling Zhiwang Decoction;rheumatoid arthritis;collagen-induced arthritis rat model;high frequency ultrasound;gray scale synovitis
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发布时间：2022-08-03 - 摘要：The research progress on the mechanisms of platycodin D (PD) on non-small cell lung cancer (NSCLC) was reviewed. PD could treat NSCLC by blocking cell growth cycle, inducing apoptosis, autophagy and inhibiting cell metastasis. At the same time, the biological characteristics, anticancer activity and side effects of PD were summarized, so as to provide ideas for its scientific research and clinical application in the treatment of NSCLC.关键词：platycodin D;NSCLC;apoptosis;autophagy;metastasis;mechanism;review
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发布时间：2022-08-03 - 摘要：This paper reviews the research progress of modified Taohong Siwu Decoction in the treatment of femoral head necrosis. Femoral head necrosis is a refractory bone disease in which the microscopic structure of the femoral head is pathologically altered by multiple factors. Modified Taohong Siwu Decoction may treat femoral head necrosis by promoting the proliferation of bone cells and endothelial progenitor cells, improving the hypercoagulable state in the blood vessels of the body, and inhibiting the absorption of bone and the apoptosis of endothelial progenitor cells.关键词：Taohong Siwu Decoction;osteonecrosis of femeral head;serum pharmacology;review
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发布时间：2022-08-03
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