最新刊期
期 3 ， 2021
- 摘要：ObjectiveTo interpret the differences in the compilation methods and content of the part of syndromes between the old and new editions of Traditional Chinese Medicine (TCM) National Standards for the purpose of promoting the application of the new editions of TCM National Standards.MethodsRelational mappings of TCM syndrome terms in the new and old TCM National Standards were compiled for the statistical analysis and text comparison of the coding mode, naming standard, compilation style, inclusion scope, classification system and definition format.Results①In terms of coding mode, the old editions of TCM National Standards had 6 digits at maximum while the new editions expanded the coding capacity by changing the coding system into no definite length in digits which made the hierarchical order in the new editions more obvious, and with the dot at the end of the code the categories of syndromes were clearly identified. ②In terms of naming standard, the new editions of TCM National Standards completely abandoned the naming method of syndromes with punctuations used in the old editions and uniformly adopted the rule of one term corresponding to one meaning. ③In terms of compilation style, the new editions of TCM National Standards added optional words, taking into account the usage conventions of syndrome terms in different regions. ④In terms of collection scope, the new editions of TCM National Standards integrated Classification and Codes of Diseases and Patterns of Traditional Chinese Medicine (GB/T 15657—1995) and Clinic Terminology of Traditional Chinese Medical Diagnosis and Treatment-Part 2: Syndromes/Patterns (GB/T 16751.2—1997) by merging the same terms, adjusting the categories of terms according to the classification system in the new editions, supplementing definitions, and removing or adding new terms. Finally, 2,060 syndrome terms were included.⑤In terms of classification system, the new editions of TCM National Standards referred to the classification system in the 11th revision of International Statistical Classification of Diseases and Related Health Problems (ICD-11) issued by World Health Organization and further integrated the corresponding classification system in the old editions. ⑥In terms of definition format, the new editions of TCM National Standards formulated a detailed and unified definition format and specifications for TCM syndrome terms, and defined the connotation and application scenarios of the included syndrome terms according to the definition specifications.ConclusionCompared with the old editions, the new editions of TCM National Standards can better satisfy the contemporary demands for the standardization and internationalization of medical informatics in China in terms of coding method, naming standard, compilation style, inclusion scope, classification system and definition format of syndrome terms.关键词：TCM National Standards;Classification and Codes of Diseases and Patterns of Traditional Chinese Medicine;Clinic Terminology of Traditional Chinese Medical Diagnosis and Treatment;TCM syndrome term;TCM syndrome classification system;TCM diagnosis;syndrome differentiation and treatment;TCM standardization
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发布时间：2022-08-03 - 摘要：Professor Cai Dingfang believes that depression is mainly blamed on the liver and closely related to the heart and kidneys. Liver depression and qi stagnation are its basic pathogenesis. He is good at using the diagnosis and treatment method of disease and syndrome differentiation and treatment, and closely integrates the three-stage treatment principle of depression of Western medicine with syndrome differentiation and treatment of traditional Chinese medicine. In the acute phase of depression, he treats the disease from liver aspect, but in the consolidation phase, he advocates the method of tonifying the kidney, and in the maintenance phase, he treats the disease based on the heart condition. And one proven case is presented.关键词：depression;disease and syndrome differentiation and treatment;experience of famous doctors;Cai Dingfang
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发布时间：2022-08-03 - 摘要：The study and exploration of Treatise on Cold Pathogenic Diseases has gradually formed multiple systems for the interpretation of the book, such as text system, annotation system, disease and syndrome system, treatment and prescription system and clinical diagnosis and treatment system. These systems have made their own breakthroughs, but further in-depth digging on their own and also holistic explorations are expected. Interpreting both ancient and modern literatures would be beneficial for the comprehensive understanding of Treatise on Cold Pathogenic Diseases.关键词：Treatise on Cold Pathogenic Diseases;text system;annotation system;disease and syndrome system;treatment and prescription system;clinical diagnosis and treatment system
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发布时间：2022-08-03 - 摘要：ObjectiveTo analyze the characteristics of traditional Chinese medicine (TCM) syndromes and manifestations of primary biliary cholangitis (PBC) and explore the corresponding distribution rules.MethodsTCM four-diagnosis information of 260 PBC cases was collected, factor analysis of selected items was conducted by using the principal component analysis (PCA), the characteristics of PBC TCM syndrome elements were determined based on the criteria of syndrome elements, and items were then clustered according to system cluster analysis method for the purpose of exploring the distribution rules of PBC TCM syndromes.Results①PBC patients mostly had qi deficiency or yin deficiency manifestations such as mental fatigue, lassitude, epigastric and hypochondriac fullness, dull pain in hypochondriac region, dry eyes, insomnia and dreaminess, inadequate appetite, dizziness, dry mouth, red tongue, and thin pulse, etc. ②The main syndrome elements of PBC disease property were yin deficiency, qi depression, damp-heat, blood stasis and qi deficiency, while the syndrome elements of PBC disease location mainly involved liver, kidney, spleen and gallbladder. ③The results of cluster analysis showed that the majority of PBC cases belonged to deficiency of liver and kidney yin syndrome (32.3%), and the rest belonged to blood stasis blocking collaterals syndrome (23.5%), liver depression and spleen deficiency syndrome (22.3%), damp-heat of liver and gallbladder syndrome (13.1%) and spleen qi deficiency syndrome (8.8%).ConclusionThe disease location of PBC involves liver, kidney, spleen and gallbladder, resulting in deficiency-excess complex syndromes in TCM. Clinically, there are liver and kidney yin deficiency syndrome, blood stasis blocking collaterals syndrome, liver depression and spleen deficiency syndrome, liver and gallbladder damp-heat syndrome and spleen qi deficiency syndrome, of which liver and kidney yin deficiency syndrome and blood stasis blocking collaterals syndrome account for a relatively higher proportion.关键词：primary biliary cholangitis;syndrome and manifestation;factor analysis;cluster analysis
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发布时间：2022-08-03 - 摘要：ObjectiveTo analyze and explore the prescription rules of traditional Chinese medicine fumigation and washing to promote postoperative wound healing of perianal abscess based on data mining.MethodsLiteratures on the promotion of postoperative wound healing of perianal abscess by traditional Chinese medicine fumigation and washing published from January 1, 2010 to December 31, 2019 were retrieved from the databases of CNKI, WanFang Data, VIP, China Biomedical Literature Service Platform (CBM), and PubMed, etc. With the help of Microsoft Office Excel 2003, IBM SPSS Statistics 23.0 and IBM SPSS Modeler 14.1 softwares, we conduced frequency analysis, the properties, taste and meridian tropism analysis of the included traditional Chinese herbal medicines(TCHMs), cluster analysis, and association rule mining of high-frequency herbs.Results①Finally 72 articles were included, involving 72 prescriptions and 93 TCHMs, which were mostly bitter cold herbs entering the liver meridian. ②The results of frequency analysis showed that there were 6 most commonly used TCHMs (f >50%), namely, Jinyinhua (Flos Lonicerae), Gancao (Radix Glycyrrhizae), Kushen (Radix Sophorae Flavescentis), Danggui (Radix Angelicae Sinensis), Huangbai (Cortex Phellodendri), and Pugongying (Taraxacum officinale). ③Cluster analysis showed that the included high-frequency TCHMs can be divided into 6 categories: TCHMs for clearing heat and removing toxin, TCHMs for clearing heat and dampness, TCHMs for activating blood and relieving pain, TCHMs for subsiding swelling and discharging pus, astringent TCHMs for arresting bleeding, and TCHMs for eliminating dampness and relieving pain and itching. ④The herbal association rule mining showed that Jinyinhua (Flos Lonicerae)-Gancao (Radix) Glycyrrhizae was a TCHM pair with relatively higher support, and Kushen (Radix Sophorae Flavescentis)-Jinyinhua (Flos Lonicerae)-Gancao (Radix Glycyrrhizae) was a TCHM group with relatively higher support.ConclusionTraditional Chinese medicine fumigation and washing can promote postoperative wound healing of perianal abscess. The basic treatment principle is to clear heat and remove toxin, supplemented by methods of promoting blood circulation and relieving pain, relieving swelling and expelling pus, astringing to arrest bleeding, and eliminating dampness to stop itching. Most traditional Chinese herbal medicines used are cold in property and bitter in taste.关键词：perianal abscess;postoperation;would healing;TCM fumigation and washing;data mining
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发布时间：2022-08-03 - 摘要：ObjectiveTo analyze the prescription rules of traditional Chinese medicine (TCM) in the treatment of constipation from the real-world perspective by mining the clinical information system.MethodsThe diagnosis and treatment information of patients diagnosed as constipation in the Health Information System of Yueyang Integrated Traditional Chinese and Western Medicine Hospital affiliated to Shanghai University of Traditional Chinese Medicine was collected from February 2015 to February 2019, and the Excel database was established. The frequency, four qi, five flavors, meridian tropism and efficacy of high frequency traditional Chinese herbal medicines(TCHMs) were analyzed with Microsoft Office Excel 2003 software; with SPSS Modeler 18.0 software the association rules of the core data were analyzed under Apriori algorithm to construct a network chart with web nodes. Factor analysis was also conducted with SPSS 16.0 statistical software.Results①A total of 16,416 constipated patients receiving TCM decoction treatment were included, which involved 731 kinds of TCHMs. ②The top five TCHMs plants frequently used were Gancao (Radix Glycyrrhizae), Huomaren (Fructus Cannabis), Baizhu (Rhizoma Atractylodis Macrocephalae), Zhishi (Fructus Aurantii Immaturus), and Houpo (Cortex Magnoliae Officinalis). Clinically, TCHMs used for constipation treatment were mainly warm, neutral and slightly cold in property, sweet and bitter in taste, mostly entering the spleen meridian, followed by stomach meridian, large intestine meridian and lung meridian. ③According to the efficacy classification, the top 3 TCHM categories in terms of use frequency were qi-invigorating TCHMs, qi-regulating TCHMs and heat-clearing TCHM. ④The results of association rule analysis showed that the TCHM combination with the highest confidence (88.28%) was Houpo (Cortex Magnoliae Officinalis)-Laifuzi (Semen Raphani)-Roucongrong (Herba Cistanches)-Dafupi (Pericarpium Arecae); A total of 11 strongly related TCHM pairs were obtained, and the top 5 TCHM pairs were Gancao (Radix Glycyrrhizae)-Baizhu (Rhizoma Atractylodis Macrocephalae), Gancao (Radix Glycyrrhizae)-Huomaren (Fructus Cannabis), Zhishi (Fructus Aurantii Immaturus)-Huomaren (Fructus Cannabis), Baizhu (Rhizoma Atractylodis Macrocephalae)-Huomaren (Fructus Cannabis), and Houpo (Cortex Magnoliae Officinalis)-Huomaren (Fructus Cannabis). ⑤Combined with TCM theoretical knowledge, 9 common factors obtained from factor analysis suggested that the prescriptions applied clinically to treat constipation were mostly modified based on classic prescriptions such as Huangqi Sijunzi Decoction, Zengye Decoction, Wuren Pill and so on.ConclusionThe clinical treatment of constipation mainly adopts the idea of promoting qi circulation and resolving stagnation, dredging fu-organs and descending qi. The overall treatment methods include dredging, tonifying and moistening, and Baizhu (Rhizoma Atractylodis Macrocephalae) is commonly used to invigorate spleen and benefit qi, and to treat obstruction with tonics.关键词：constipation;real-world data;traditional Chinese medicine;data mining
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发布时间：2022-08-03 - 摘要：This paper discusses Professor Li Zhenhua’s experience in differential treatment of spleen and stomach diseases with pattern of heat in the upper and cold in the lower. The pattern of heat in the upper and cold in the lower refers to a state of imbalance between yin and yang, which belongs to the category of syndrome of cold and heat complex. As most of the spleen and stomach diseases are caused by the qi obstruction in middle energizer, when treating the disease, both the cold and warm Chinese herbal medicines should be used and attention should be paid to the recuperation of qi activity in middle energizer based on the treatment principle of Treatise on Exogenous Febrile Disease and Miscellaneous Diseases, so as to achieve the effect of equilibrium between yin and yang. And two proven cases are presented.关键词：spleen and stomach diseases;pattern of heat in the upper and cold in the lower;Treatise on Exogenous Febrile Disease and Miscellaneous Diseases;qi activity;expert experience;LI zhenhua
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发布时间：2022-08-03 - 摘要：This paper aims to introduce Professor Cao Yemin’s clinical experience in the treatment of diabetic foot gangrene (tendon gangrene). Professor Cao believes that the main pathogenesis of tendon gangrene is exogenous damp-heat, blood stasis blocking collaterals and deficiency of qi and yin, and he divides the progress of tendon gangrene into acute onset stage and recovery stage. In the acute onset stage, the internal treatment of traditional Chinese medicine (TCM) is mainly to clear away damp-heat, promote diuresis and remove toxin by adopting modified Huanglian Jiedu Decoction plus Yinchenhao Decoction besides the conventional treatment (controlling blood sugar and infection, improving hypoalbuminemia with TCM therapeutic diet) and external treatment of removing decaying tissues along the tendons. In the recovery stage, "nourishing" is the primary therapeutic principle combined with the external treatment of rodent debridement. As for the dual deficiency of qi and yin syndrome, modified Shengmai Decoction plus Liuwei Dihuang Decoction is used to replenish qi and nourish yin; as for the dual deficiency of qi and blood syndrome, modified Bazhen Decoction is used to replenish qi and nourish blood. Two proven cases are presented.关键词：diabetic foot;gangrene;tendon gangrene;treatment by staging;clearing heat and promoting diuresis;famous doctor’s experience
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发布时间：2022-08-03 - 摘要：This paper explores Professor Liang Xiaochun’s clinical experience in the diagnosis and treatment of vertigo. Professor Liang Xiaochun believes that vertigo is located in the brain, which is closely related to the liver, kidney and spleen. Various pathogenic factors lead to the dysfunction of the abovementioned three organs, resulting in deficiency, wind, phlegm, fire and blood stasis, which are often causal and intermingled with each other. However, kidney deficiency and liver hyperactivity is the root cause, and mutual obstruction of phlegm and blood stasis is the cause of symptoms. In the treatment of vertigo, physicians should carefully identify the syndrome and the cause of the disease, starting with tonifying the deficiency and reducing the excess, first paying attention to the deficiency, and then attaching importance to the four elements of wind, phlegm, fire and blood stasis. According to the pathogenic condition of the patients, physicians should flexibly use following methods such as nourishing the kidney and calming the liver, or stopping wind, removing phlegm, resolving turbidity, lowering fire or eliminating blood stasis, and simultaneously treating the root cause and symptoms and regulating deficiency and excess. And one proven case is presented.关键词：vertigo;kidney deficiency and liver hyperactivity;mutual obstruction of phlegm and blood stasis;experience of famous doctors;Liang Xiaochun
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发布时间：2022-08-03 - 摘要：This paper introduces Professor Guo Yu’s experience in the treatment of intractable ear diseases by using modified Xuanfu Daizhe Decoction combined with acupoint injection. It is believed that clinically attention should be paid to the effective combination of internal administration of Traditional Chinese Medicine combined with external treatment of Traditional Chinese Medicine and Xuanfu Daizhe Decoction and acupoint injection are commonly used with good results. And one proven case is presented.关键词：intractable ear disease;Xuanfu Daizhe Decoction;acupoint injection;expert experience;Guo Yu
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发布时间：2022-08-03 - 摘要：The important role of spleen and stomach in the occurrence and development of stoke was discussed from three aspects: Based on the theory of stomach in control of dredging and descending, the pathogenesis of acute stroke was fu-organs excess due to qi disturbance, so the dredging fu-organs therapy was established to eliminate pathogenic factors, and Xinglou Chengqi Decoction was recommended; Because the spleen was the source of phlegm production, and phlegm was an important pathological factor of stroke, so eliminating phlegm and strengthening spleen should be applied. According to the period of the disease and the specific syndrome type, medication should be used differently; Spleen and stomach deficiency could cause stroke and stroke for a long time could result in qi deficiency and blood stasis. It was necessary to apply the method of invigorating spleen and benefiting qi, and Buyang Huanwu Decoction was recommended.关键词：spleen and stomach theory;stroke;TCM therapy;application
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发布时间：2022-08-03 - 摘要：ObjectiveTo observe the effect of Tai Chi footwork on walking ability of hemiplegic patients following ischemic stroke based on three-dimensional gait analysis.MethodsSixty patients with hemiplegia after ischemic stroke were randomly divided into control group (n=30) and experimental group (n=30). The control group received conventional rehabilitation training, while the experimental group received standardized Tai Chi footwork training. The course of treatment in both groups was 30 days. The three-dimensional gait and motion analysis system was used to detect and evaluate patients’ kinematic parameters of time and space variables.Results①There was no drop-out case during the trail. ②In the experimental group, the stride time was shortened, the proportion of supporting phase of the healthy side reduced, and the proportion of swinging phase of the healthy side increased after treatment (P<0.05), while there was no significant difference in the proportion of supporting phase and swinging phase of affected side before and after treatment(P>0.05). In the control group, the stride time was shortened, the proportion of supporting phase of the healthy side reduced, the proportion of swinging phase of the healthy side increased, the proportion of supporting phase of the affected side increased, and the proportion of swinging phase of the affected side reduced after treatment(P<0.05). After treatment, the stride time in the experimental group was significantly shorter than that in the control group, the proportion of supporting phase of the affected side was significantly lower than that in the control group, and the proportion of swinging phase of the affected side was significantly higher than that in the control group (P<0.05). There was no significant difference in the proportion of supporting phase and swinging phase of healthy side between the two groups after treatment (P>0.05). ③In the experiment group, the stride length was lengthened, the stride speed was accelerated, the stride width was shortened, and the step length of healthy and affected foot was lengthened after treatment (P<0.05). In the control group, the stride length was lengthened, the stride speed was accelerated, the stride width was shortened, the step length of affected foot was lengthened (P<0.05), and there was no significant difference in the step length of healthy foot before and after treatment (P>0.05). After treatment, the stride length of the experimental group was significantly longer than that of the control group, the stride speed was significantly faster than that of the control group, and the stride width was significantly shorter than that of the control group (P<0.05). There was no significant difference in the step length of healthy foot and affected foot between the two groups (P>0.05).ConclusionCompared with conventional rehabilitation training, Tai Chi footwork training can significantly improve the overall walking ability of hemiplegic patients following ischemic stroke, and improve the supporting and swinging ability of the affected lower limbs.关键词：Taijiquan;Tai Chi footwork;ischemic stroke;hemiplegia;gait analysis;rehabilitation training
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发布时间：2022-08-03 - 摘要：ObjectiveTo observe the clinical efficacy of Xiao Chaihu Decoction combined Zhibai Dihuang Decoction in treatment of CKD3-4 period.MethodsNinety patients with CKD3-4 period were randomly divided into treatment group and control group,45 patients in each group. All the patients were treated with basic therapy. In addition, the treatment group was given Xiao Chaihu Decoction combined Zhibai Dihuang Decoction. The treatment course was 8 weeks in both group. The clinical efficacy, relevant laboratory indicators (Scr, BUN, Ccr)and TCM syndrome scores were observed.ResultsThe total effective rate of the treatment group and the control group were 93.33% and 66.66% respectively, and the clinical efficacy of the treatment group was better than that of the control group( P<0.05). After treatment, the level of Scr, BUN, Ccr, and the TCM syndrome scores were significantly improved in both groups ( P<0.05) and they were significantly better in the treatment group than those in the control group ( P<0.05).ConclusionsXiao Chaihu Decoction combined Zhibai Dihuang Decoction could improve clinical symptoms and renal function of patients with CKD3-4 period. The clinical efficacy was satisfactory.关键词：chronic kidney disease;Xiao Chaihu Decoction;Zhibai Dihuang Decoction;clinical efficacy
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发布时间：2022-08-03 -
Effect of Shugan Hewei Granules on reflux esophagitis of stagnant heat in liver and stomach syndrome
摘要：ObjectiveTo evaluate the clinical effect of Shugan Hewei Granules on reflux esophagitis of stagnant heat in the liver and stomach syndrome.MethodsTotally 94 patients suffering from reflux esophagitis of stagnant heat in the liver and stomach syndrome were randomly divided into test group (n=47) and control group (n=47). The test group was treated with Shugan Hewei Granules and the control group was treated with omeprazole; the course of treatment in both groups was 8 weeks, and the clinical therapeutic effect, clinical symptom score and esophageal mucosal grading under gastroscopy were observed.ResultsAll 94 enrolled patients completed the 8-week course of treatment, and 76 of them actually completed the gastroscopy review after the course of treatment. The total effective rates of the treatment and improvement of esophageal mucosal inflammation under gastroscopy in the test group were 95.74% and 80.005% respectively, while those in the control group were 76.60% and 63.89% respectively. The clinical therapeutic effect and the improvement of esophageal mucosal inflammation under gastroscopy in the test group were better than those in the control group (P<0.05).After treatment, the clinical symptom scores of the two groups decreased significantly (P<0.05), and there was significant difference in the clinical syndrome scores between the two groups after treatment (P<0.05). After treatment, the grade of esophageal mucosal inflammation significantly improved in both groups (P<0.05), and there was significant difference in the grade of esophageal inflammation under gastroscopy between the two groups after treatment (P<0.05).ConclusionShugan Hewei granules has obvious clinical effect on reflux esophagitis of stagnant heat in the liver and stomach syndrome, as it can improve clinical symptoms and reduce esophageal mucosal inflammation.关键词：reflux esophagitis;pattern of stagnant heat in liver and stomach;Shugan Hewei granules;clinical efficacy- 8
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发布时间：2022-08-03 - 摘要：ObjectiveTo observe the clinical efficacy of wrist-ankle acupuncture combined with western medicine on allergic rhinitis in children.MethodsOne hundred children with allergic rhinitis were randomly divided into the control group and treatment group, 50 cases in each group. The control group was treated with western medicine according to the guidelines, and the treatment group was treated with wrist-ankle acupuncture based on the treatment for the control group. The course of treatment in both groups was 4 weeks. The clinical efficacy and the recurrence rate were observed, the clinical scores of symptoms and signs and the serum immunoglobulin E (IgE) level were compared, and the safety evaluation was performed.Results①The total effective rate of the treatment group was 90.00%, the that of the control group was 58.00%, the clinical efficacy of the treatment group was better than that of the control group (P<0.05). ② Compared with those before treatment, the scores of symptoms and signs and the serum IgE level in both groups were decreased after treatment(P<0.05). After treatment, the scores of symptoms and signs and the serum IgE level in the treatment group were lower than those in the control group (P<0.05). ③Followed up for 3 months, the recurrence rate of the treatment group was 6.67%, which significantly lower than that of the control group (27.59%) (P<0.05). ④During the treatment, there were no abnormalities in the safety related indexes of children in both groups, and no obvious adverse reactions were found.ConclusionCompared with the treatment with western medicine alone, wrist-ankle acupuncture combined with western medicine shows good efficacy in the treatment of allergic rhinitis in children, which can better improve the clinical symptoms and reduce the recurrence rate, with good safety.关键词：allergic rhinitis;children;external therapy of traditional Chinese medicine;wrist-ankle acupuncture
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发布时间：2022-08-03 - 摘要：ObjectiveTo select out the optimal compatibility of Jiangzhi Granule components for improving non-alcoholic fatty liver disease (NAFLD).Methods①HepG2 and L02 cells were induced by fatty acids for 24 hours to establish a model of hepatosteatosis (model group, M).Six compatibility groups (named A, B, C, D, E, F) combined by 3 major components of Jiangzhi Granule (including protopanaxadiol, tanshinoneⅡA and emodin) according to the weighed modification method were used to intervene the model cells for 24 h. Cells cultured in the normal medium were used as normal control. The optimal proportion group was selected according to the effect of drugs on alleviating lipid accumulation observed by oil red O staining and intracellular triglyceride (TG) 、total cholesterol (TC) content. The effect of the optimal group was also compared with the individual effect of the three active components.②SPF male C57BL/6J mice were randomly divided into normal group, model group, compatible F high-dose group and compatible F low-dose group according to their body weight, with 8 mice in each group. The mice in the normal group was fed with ordinary feed, and the rest were given high-fat feed. After 22 weeks of inducting NAFLD modeling, the mice were treated with corresponding drugs for 8 weeks. The body weight, liver weight, serum alanine aminotransferase (ALT), serum lipid and hepatic histopathological changes were detected to verify the efficacy of the optimal compatibility.Results①Cell oil red O staining showed that a large number of lipid droplets accumulated in the cells of the model group, which were alleviated in different degrees in all of the 6 compatibility groups. The detection of cellular TG content showed that the TG content in the group M increased, while the level of TG decreased significantly in the group C and the group F, among which group F had the most significant effect. Moreover, the effect of group F on reducing lipid accumulation was better than protopanaxadiol, tanshinone ⅡA and emodin alone. ②The body weight, liver weight and serum ALT of NAFLD mice in model group were significantly higher than those in the control group, and the intervention of compatible F high-dose group could significantly reduce the level of liver weight and ALT. Both compatible F high-dose group and compatible F low-dose group could reduce the level of serum TC in NAFLD mice, and compatible F high-dose group could significantly down-regulate the levels of high density lipoprotein cholesterol (HDL-c) and low density lipoprotein cholesterol (LDL-c). HE staining and oil red O staining showed that compatible F high-dose group and compatible F low-dose group improved hepatocyte steatosis in a dose-dependent manner.ConclusionThrough the experiment in vivo and in vitro, the drug compatibility group F composed of propanaxadiol, tanshinone ⅡA and emodin is selected out, which can improve serum lipid, hepatosteatosis and liver function of NAFLD model and helps to establish the experimental basis for the development of new type of drugs for NAFLD with controllable quality and stable therapeutic effects.关键词：NAFLD;mice;protopanaxadiol;tanshinoneⅡA;emodin;components combination;weighed modification method
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发布时间：2022-08-03 - 摘要：ObjectiveTo explore whether BMP and activin membrane bound inhibitor(BAMBI), an endogenous "pseudo-receptor" of transforming growth factor β(TGF-β), could be involved in the anti-liver fibrotic effects of Huangqi decoction(HQD).MethodsLiver fibrosis was induced in male C57BL/6 mice by 10% CCl4(2 g/kg body weight, ip), three times per week, for 6 weeks. From the 4th week, the CCl4 model mice were randomly divided into two groups: treated with vehicle(M)and HQD, respectively, for 3 weeks through gavage. In vitro cultured LX-2 cells(a human hepatic stellate cell line)were used to detect the effect of HQD’s major effective components astragalosides(AS)and glycyrrhizic acid(GA)on TGF-β signaling and gene expression.ResultsHQD treatment significantly attenuated CCl4-induced abnormal increase of serum ALT and AST(P<0.01). H&E staining and Sirius red staining on liver tissue sections revealed that HQD treatment significantly attenuated CCl4-induced liver tissue damage and inflammation, and reduced liver collagen deposition. Real-time PCR results revealed that HQD treatment reduced the abnormal overexpression of collagen-1(Col1α1) and matrix metalloproteinase-12(Mmp-12)mRNA(P<0.05). Furthermore, compared with the M group, the liver expression of Bambi mRNA was significantly enhanced in the HQD group(P<0.01). Cell culture studies demonstrated that the treatment of LX-2 cells with AS and GA inhibited TGF-β1-induced LX-2 cell activation and collagen synthesis, inhibited lipopolysaccharide-induced tumor necrosis factor-α expression(P<0.01), and enhanced BAMBI expression(P<0.01).ConclusionThese results revealed that inhibiting liver inflammation and upregulating the expression of BAMBI could be one of the important mechanisms for HQD to effectively reduce liver fibrosis.关键词：Huangqi Decoction;total astragalus saponins;glycyrrhizic acid;liver fibrosis;bone morphogenetic protein and activin transmembrane inhibitor (BAMBI);TGF-β1
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发布时间：2022-08-03 - 摘要：ObjectiveTo investigate the therapeutic effects of Simiao Pill and Liujunzi Pill on hyperuricemic (HUA) rats with insulin resistance (IR) induced by high fat diet combined with fructose water feeding and potassium oxazinate intragastric administration.MethodsOf the 36 male Wistar rats, 6 were in the blank group (without intervention) and the others were established the model of HUA combined with IR. After successful modeling, they were randomly divided into 5 groups: model group, benzbromarone group (benzbromarone 0.83 g/kg), febutastat group (febutastat 1.24 g/kg), Simiao Pill group (Simiao Pill 1.38 g/kg), Liujunzi Pill group (Liujunzi Pill 1.73 g/kg), with 6 rats in each group. After 4 weeks of drug administration, the body weight and the abdomin-fat weight of the rats were recorded, and indexes including serum uric acid (UA), insulin (INS), insulin resistance index(HOMA-IR), fasting serum glucose (FPG) fasting serum lipid [total cholesterol (TC), triglyceride (TG), low density lipoprotein (LDL-c), high density lipoprotein (HDL-c)], urea nitrogen (BUN), creatinine (SCr), liver xanthine oxidase (XOD) activity and renal uric acid transporter URAT1 expression were detected.Results①The body weight and abdomin-fat weight of the model group and the administration groups were significantly higher than those of the blank group (P<0.01), while the abdominal-fat of Simiao Pill group and Liujunzi Pill group was significantly lower than that of the model group, benzbromarone group and febutastat group. ②UA, INS, FPG and HOMA-IR in the model group were significantly higher than those in the blank group (P<0.05, P<0.01). The levels of UA, INS and HOMA-IR in the administration groups were lower than those in the model group (P<0.05,P<0.01). Among them, the decrease of UA was most significant in the febuxostat group (P<0.01) and the reduction of HOMA-IR was most significant in the Simiao Pill and the benzbromarone group (P<0.01).③There were no significant difference in serum lipids, BUN, and SCr among all groups (P>0.05). ④Compared with the model group, Simiao Pill and febuxostat inhibited the activity of XOD (P<0.05).⑤ Compared with the model group, Simiao Pill, Liujunzi Pill and benzbromarone down-regulated the expression of URAT1 (P<0.01).ConclusionSimiao Pill and Liujunzi Pill can reduce UA and improve IR, which provide an idea for the treatment of HUA complicated with IR by fortifying the spleen, clearing heat and disinhibiting dampness.关键词：hyperuricemia;insulin resistance;rats;Simiao Pill;Liujunzi Pill
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发布时间：2022-08-03 - 摘要：ObjectiveTo study the effect of Xingshen Jieyu Decoction on serum Th1/Th2 and brain-derived neurotrophic factor(BDNF) levels in post-stroke depressive (PSD) rats, and to analyze the possible mechanism of Xingshen Jieyu Decoction in treating the disease.MethodsSD rats were randomly divided into normal group, stroke group, post-stroke depression group, sertraline group, low-dose group of Xingshen Jieyu Decoction, and high-dose group of Xingshen Jieyu Decoction. The stroke model was established by the right middle cerebral artery ischemia-reperfusion operation. The chronic unpredictable mild stress (CUMS) method was added at 3 days after the middle cerebral artery occlusion (MCAO) operation for PSD model. In the medicine groups the sertraline (5.142 g/kg) and high or low dose (56.148 g/kg, 18.176 g/kg) of Xingshen Jieyu Decoction were used after the establishment of PSD model respectively. The enzyme-linked immunosorbent assay (ELISA) was used to detect the contents of serum inflammation factors including Th1 (IL-6, IFN-γ), Th2 (IL-4, IL-10) and BDNF.ResultsCompared with those in the normal group, the serum Th1/Th2 ratio in the post-stroke depression group increased significantly, the levels of anti-inflammatory factors such as IL-4, IL-10, and BDNF decreased significantly, and the levels of pro-inflammatory factors such as IL-6 and IFN-γ increased significantly (P<0.05); compared with those in the post-stroke depression group, the serum Th1/Th2 ratio was decreased significantly and the contents of IL-4, IL -10 and BDNF were increased significantly, but the contents of IL-6 and IFN-γ were decreased significantly (P<0.05) in the post-stroke depression groups with low-dose, high-dose of Xingshen Jieyu Decoction.ConclusionXingshen Jieyu Decoction can improve the neurological function and depressive behavior of post-stroke depression rats by regulating the levels of Th1 / Th2 and BDNF.关键词：post-stroke depression;rats;Xingshen Jieyu Decoction;Th1/Th2;brain derived neurotrophic factor
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发布时间：2022-08-03 - 摘要：Advances in traditional Chinese medicine research of non-alcoholic fatty liver disease (NAFLD) were reviewed from the aspects of disease name, etiology and pathogenesis, clinical treatment, and experimental research. NAFLD belongs to the category of "Gan Pi" (liver stuffiness) in traditional Chinese medicine. Factors such as emotions, diet, work and rest, and prolonged illness, etc. are triggers for the onset of disease. Deficiency and excess complex, cold and heat complex are common pathogenesis due to the intermingling and interactions of various pathological factors such as liver depression, spleen deficiency, dampness accumulation, qi stagnation, blood stasis, and phlegm coagulation, etc. Clinically, the basic therapeutic principle is to combine tonification and purgation. At present, there are some problems such as insufficient in-depth research on pathogenesis of different stages of NAFLD, lack of unified syndrome differentiation standards and effective scientific evaluation system. The emerging systems biology technology platforms such as metabonomics and genomics are highly recommended for broadening the research on the material basis and action mechanism of traditional Chinese medicine in the treatment of NAFLD, and facilitating the standardization, systematization and normalization of traditional Chinese medicine diagnosis and treatment of NAFLD.关键词：non-alcoholic fatty liver disease;metabolic-related fatty liver disease;traditional Chinese medicine;Gan Pi;review
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发布时间：2022-08-03 - 摘要：Thsi paper sumarizes the research progress about the mechanism of traditional Chinese medicine in treating asthmatic airway inflammation in recent years.Compound or single traditional Chinese medicine and its extracts can treat asthmatic airway inflammation through adaptive immune regulation, inhibition of antigen presentation, innate immune regulation, inhibition of oxidative stress, improvement of antioxidant capacity, inhibition of NLRP3 inflammasome formation, and inhibition of inflammatory response pathways.At the same time, studies on network pharmacology, high performance liquid chromatography, genomics, proteomics and other studies have shown the interaction between active ingredients, and further revealed the mechanism of multi-target and multi-channel treatment of asthma airway inflammation by traditional Chinese medicine.关键词：asthma;anti-inflammation;medicine traditional Chinese;chronic airway inflammation;review
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发布时间：2022-08-03
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