最新刊期
期 2 ， 2021
- 摘要：ObjectiveTo interpret the differences in the compilation methods and content of the part of diseases between the old and new editions of Traditional Chinese Medicine (TCM) National Standards-Classification and Codes of Diseases and Patterns of Traditional Chinese Medicine(GB/T 15657—1995) and Clinic Terminology of Traditional Chinese Medical Diagnosis and Treatment(GB/T 16751—1997) for the purpose of promoting the application of the new editions of TCM National Standards.MethodsRelational mappings of TCM disease terms in the new and old TCM National Standards were compiled for the statistical analysis and text comparison of the coding mode, naming standard, compilation style, inclusion scope, classification system and definition format.Results①The revised edition of Classification and Codes of Diseases and Patterns of Traditional Chinese Medicine improved its coding mode by referring to its disease classification, which was simpler to understand, and much easier to expand terms due to its larger terminological capacity. All the terms of diseases and patterns realized one-to-one correspondence between code and term. ②The naming standard formulated in the new editions of TCM National Standards. All the terms of diseases followed the principle that one term corresponds to only one meaning. There were no square brackets or parentheses in the terms. The information in the brackets or parentheses in the old editions(GB/T 15657—1995 and GB/T 16751—1997) was expressed in hierarchical order or with optional words (i.e. synonyms). ③Compared with GB/T 16751—1997, the new editions of TCM National Standards had a separate line for each code, and also added an English translation of disease name and corresponding annotations for each term were added. ④One thousand three hundred and sixty-nine terms of disease names were included in the revised edition of Classification and Codes of Diseases and Patterns of Traditional Chinese Medicine and Clinic Terminology of Traditional Chinese Medical Diagnosis and Treatment-Part 1: Diseases. The terms of disease names in new TCM National Standards were exactly the same and corresponded to each other. ⑤The new editions of TCM National Standards abandoned the classification system used in GB/T 16751—1997, and formed a disease classification system with basic elements of TCM etiology, pathogenesis and disease location, which was not only connected with the disease classification principles in WHO ICD-11, but also supported by TCM academic theories and unified with TCM clinical practice. The "symptomatic naming" in GB/T 16751—1997 was changed to "terminology for provisional diagnosis" . ⑥The new editions of TCM National Standards stipulated the format for term definitions. The definition of TCM disease terms should include the corresponding etiology, pathogenesis, disease location, characteristic symptoms and categories of the disease. Meanwhile, the terms to be defined should be divided into two categories: category words and specific terms. Descriptors for the definition of disease terms were also standardized.ConclusionCompared with the old editions, the new editions of TCM National Standards has been optimized and revised in terms of the coding mode, naming standard, compilation style, inclusion scope, classification system, definition format and other aspects of disease terms to better facllitate the quality evaluation, health management, health statistics and other TCM related work, and the new editions are more in line with the contemporary demands for medical informatics and TCM standardization and internationalization in China.关键词：TCM National Standards;TCM disease terminology;Classification and Codes of Diseases and Patterns of Traditional Chinese Medicine;Clinic Terminology of Traditional Chinese Medical Diagnosis and Treatment;TCM disease classification system;TCM standardization
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发布时间：2022-08-03 - 摘要：This paper introduced professor Peng Peichu’s experience in treating overactive bladder (OAB) by tranquilizing liver-wind.Based on the theory of "liver presiding urine" , professor Peng considered that the basic pathogenesis of OAB was liver-wind stirring and should be treated by tranquilizing liver-wind.The basic prescription was modified Zhengan Xifeng Decoction. At the same time, Ganmai Dazao Decoction was commonly used to adjust the emotions of patients, self-formula Nianmo Decoction was used to protect patients’ spleen and stomach, and Suanzaoren Decoction was used to regulate sleep of patients.A proven case was presented.关键词：overactive bladder;tranquilizing liver-wind;famous expert experience;Peng Peichu
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发布时间：2022-08-03 - 摘要：The diagnosis and treatment strategy of Wei’s traumatology was introduced in the treatment of distal radius fracture. With continuous inheritance and development, Wei’s traumatology takes "diagnosis-treatment-rehabilitation" as the working point for distal radius fracture treatment, and has formed a comprehensive treatment plan integrating reduction by manipulation, splint fixation, oral administration and external application of traditional Chinese medicine and Daoyin method of Wei’s traumatology in the early, middle and advanced stages of fractures, which significantly improves the clinical efficacy of the disease.关键词：Wei’s traumatology;distal radius fracture;non-surgical therapy;Chinese osteology;reduction by manipulation;small splint fixation method;TCM Daoyin method
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发布时间：2022-08-03 - 摘要：ObjectiveTo explore the pharmacological mechanism of Fangfeng(Radix Saposhnikoviae)-Qinjiao(Radix Gentianae Macrophyllae) in the treatment of lumbar disc herniation (LDH) .MethodsThe active ingredients and targets of Fangfeng-Qinjiao were screened by Traditional Chinese Medicine System Pharmacology Datebase(TCMSP), and the obtained target protein names were converted into Gene Symbol by Uniprot database; the targets of LDH were searched and screened from GeneCards and OMIM database; the common targets of drug-disease were screened by R software and Venn diagram was drawn. Cytoscape 3.7.0 software was used to construct drug and disease active ingredient-target network map; String database was used to construct protein interaction network of the target and corresponding analysis was performed with R3.6.3 software; GO functional analysis and KEGG pathway enrichment analysis of drug core targets were performed with the "clusterProfiler" R software package, and the results were visualized by R software.ResultsTwenty active ingredients of the herb pair and 19 targets of drug-diseases were obtained through screening.The commonly used TCM ingredients were wogonin, beta-sitosterol, 5-O-Methylvisamminol and the key targets were PTGS2, NOS2, AR and ESR1 through drug-disease component target network diagram.The common target PPI network obtained five potential targets with degree values ≥16, which including IL-6, AKT1, CASP3, CXCL8 and PTGS2; A total of 811 enriched items were obtained by GO analysis, including 771 items of biological process, 33 items of molecular function and 7 items of cell component(P<0.05); 39 pathways including IL-17 signaling pathway, TNF pathway, AGE-RAGE signaling pathway were obtained by KEGG analysis(P<0.05).ConclusionFangfeng-Qinjiao may exert anti-inflammatory, anti-oxidative stress, anti-apoptosis and regulate immunity through multi-component, multi-target and multi-pathway pathway, thus playing a role in the treatment of LDH.关键词：wind-dispelling drugs;Radix Saposhnikoviae;Radix Gentianae Macrophyllae;lumbar disc herniation;network pharmacology
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发布时间：2022-08-03 - 摘要：ObjectiveTo explore the correlation between colorectal polyps and patient’s TCM constitution types for the purpose of providing evidence-based medical basis for prevention and treatment of colorectal polyps.MethodsThe clinical research literature on the correlation between TCM constitution types and colorectal polyps were retrieved from China National Knowledge Infrastructure (CNKI), Chongqing VIP fulltext periodical database (VIP), Wanfang data, China Biomedical Literature Database, PubMed, EMBASE, Cochrane Library from the beginning of database establishment to 2018. Based on the inclusion and exclusion criteria, the literatures that finally met the inclusion criteria were manually screened out, and the valid data were extracted. The American Health Care Quality and Research Institute (AHRQ) Cross-Sectional (Prevalence) Study Quality Checklist was applied to evaluate the quality of the literatures, and the relevant literatures were meta-analyzed by R software and Review Manager 5.3 software.Results①Finally 16 articles included were all cross-sectional studies, of which the sample size of colorectal polyps reached 2,341. ②Among patients with colorectal non-adenomatous polyps included in 7 studies, the number of patients with damp-heat constitution, qi-deficiency constitution, yang-deficiency constitution and phlegm-dampness constitution accounted for a higher proportion of the total number, all exceeding 10%. Among patients with colorectal non-adenomatous polyps included in 13 studies, the number of patients with phlegm-damp constitution, damp-heat constitution, yang-deficiency constitution and qi-deficiency constitution accounted for a higher proportion of the total number, all exceeding 10%. ③There were 4 studies that compared the constitution types of patients with and without adenomatous polyps, involving 678 cases. After data integration and analysis, it was found that the odds ratio (OR) value of adenomatous polyp risk was relatively higher in patients with damp-heat constitution, phlegm-dampness constitution, yang-deficiency constitution and yin-deficiency constitution respectively, and the adenomatous polyp risk was significantly higher than the non-adenomatous polyp risk in patients with phlegm-dampness constitution and yang-deficiency constitution. ④A total of 3 studies compared the constitution types of patients with progressive adenomatous polyps and of those with non-progressive adenomatous polyps, involving 345 cases. After data integration and analysis, it was found that the OR values of the risk of progressive adenoma polyp risk was relatively higher in patients with damp-heat constitution, phlegm-dampness constitution, yang-deficiency constitution, qi-deficiency constitution, yin-deficiency constitution, allergic constitution and mild constitution, and the progressive adenoma polyp risk was significantly higher than the non-progressive adenoma polyp in patients with phlegm-dampness constitution and qi-deficiency constitution. ⑤AHRQ Cross-Sectional (Prevalence) Study Quality Checklist was used to evaluate the methodological quality of the 16 studies included. It was found that the overall quality of literatures included was relatively low and there was a relatively high risk of bias.ConclusionDamp-heat constitution, phlegm-dampness constitution, yang-deficiency constitution and qi-deficiency constitution are the main constitution types of patients with colorectal polyps (including adenomatous polyps), of which yang-deficiency constitution and phlegm-dampness constitution are the primary risk factors for the onset of colorectal adenomatous polyps, while phlegm-dampness constitution and qi-deficiency constitution are the primary risk factors for the onset of progressive adenomatous polyps.关键词：TCM constitution;colorectal polyps;colonic polyps;correlation;risk factor;evidence-based basis;systematic review;Meta-analysis
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发布时间：2022-08-03 - 摘要：This paper introduces professor Li Yan’s experience in the treatment of brain tumor with common couplet drugs. Professor Li can cautiously grasp pathogenesis, flexibly treat with syndrome differentiation and is skilled in using couplet drugs to treat brain tumors. For instance, Radix Astragali and Rhizoma Atractylodis Macrocephalae are commonly used to strengthen spleen and replenish qi; Rhizoma Amorphophalli and Rhizoma Pinelliae are commonly used to resolve phlegm and soften hard masses. Rhizoma Sparganii and Rhizoma Curcumae are commonly used to improve blood circulation and disperse stasis. Fructus Lycii and Fructus Ligustri Lucidi are commonly used to tonify kidney and nourish yin. Semen Cuscutae and Semen Astragali Complanati are commonly used to tonify kidney and support yang. Edible Tulip and Radix Semiaquilegiae are commonly used to clear away heat and toxic material. Scorpio and Scolopendra are commonly used to relieve convulsion and spasm.关键词：brain tumor;couplet drugs;expert experience;Li Yan
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发布时间：2022-08-03 - 摘要：This paper explores the clinical experience of treating slow-fast syndrome from deficiency.It is considered that the incidence of the disease is due to the weakening of the function of the heart and spleen, and the deficiency of yin and yang is its basic pathogenesis.The disease is treated with modified Zhi Gancao(prepared Radix Glycyrrhizae) Decoction by the method of replenishing qi and nourishing yin, activating yang and restoring pulse. And one proven case is presented.关键词：slow-fast syndrome;deficiency of yin and yang;Zhi Gancao Decoction;clinical experience
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发布时间：2022-08-03 - 摘要：From the aspects of Qiao Meridians connecting with brain, yinqiao being the derived meridian of Kidney Meridian and yangqiao being the derived meridians of Bladder Meridian, Qiao Meridians mainly responsible for body movement, the disease of Qiao Meridians being characterized by relaxation of yang meridian and tension of yin meridian or relaxation of yin meridian and tension of yang meridian, and the physiological function of Qiao Meridians being internal irrigating of viscera and external moistening of skin, this paper discusses the correlation between Qiao Meridians and spastic paralysis after stroke so as to provide theoretical basis for the treatment of spastic paralysis after stroke from the theory of Qiao Meridians.关键词：stroke;spasm;paralysis;Qiao Meridians;acupuncture
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发布时间：2022-08-03 - 摘要：Combined with the clinical cases of multiple convulsions, allergic rhinitis and acute bronchitis, this paper introduces Zhang Guohai’s experience in using Gujingcao(Flos Eriocauli ) Mixture and by the method of treating same disease with different methods to treat pediatric diseases, which are caused by the pathogenic factors of fire and wind, heat and wind or fire, heat, and wind.关键词：pediatric disease;Gujingcao Mixture;expert experience;Zhang Guohai;treating different diseases with same method
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发布时间：2022-08-03 - 摘要：This paper introduces the experience of using Professor Huang Huang’s classical prescription and constitution theory to treat infantile cough. According to the characteristics of different constitution of children, the classical prescriptions such as Guizhi plus Houpu Xingzi Decoction, Shenmi Decoction, Wuhu Erchen Decoction and Xiao Chaipu Decoction were used to treat the disease. And in this paper, the main constitutional points for using the four kinds of classical prescriptions are analyzed respectively and demonstrated with proven cases.关键词：classical prescription;constitution theory;infantile cough and asthma;Huang Huang;clinical experience
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发布时间：2022-08-03 - 摘要：This paper discusses the clinical experience of using classical prescriptions in differential treatment of sweating syndrome combined with 5 cases. It is considered that sweating syndrome is the syndrome of abnormal sweat leakage, and it is a kind of pathological sweating, mainly caused by the imbalance of yin and yang, the disharmony between nutrient qi and defensive qi, and the abnormal opening and closing of pores. As the key pathogenesis of sweating syndrome is the disharmony between nutrient qi and defensive qi, the main prescription for the syndrome is Guizhi Decoction combined with Chaihu prescriptions and Baihu prescriptions.关键词：sweating disorders;spontaneous sweating;imbalance of yin and yang;disharmony between nutrient qi and defensive qi;classical prescription;Guizhi Decoction
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发布时间：2022-08-03 - 摘要：From the perspectives of five elements theory and visceral state theory, this paper analyzes the reasons why doctors in past dynasties talked more about "lung qi" than "lung yang" . And it explores the relationship between "lung yang" , "lung yang deficiency" and the pathological mechanism of asthma with syndrome of cold fluid retention in lung, as well as the influence of "lung yang deficiency" state on asthma with syndrome of cold fluid retention in lung. Accordingly, it is proposed that " lung yang deficiency " can inhibit the autophagy level of the body and increase the level of airway inflammation, which leads to the pathogenesis of asthma with syndrome of cold fluid retention in lung.关键词：lung yang deficiency;bronchial asthma;syndrome of cold fluid retention in lung;tonifying lung yang;pathological mechanism
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发布时间：2022-08-03 - 摘要：ObjectiveTo observe the clinical effect of modified Qinghua Hezhong(QHHZ) Decoction in the treatment of chronic non-atrophic gastritis (CNAG) with spleen and stomach damp-heat (SSDH) syndrome.MethodsA total of 82 patients with CNAG were randomly divided into treatment group and control group with 41 cases in each group. Patients in the treatment group were treated with modified QHHZ Decoction, while patients in the control group were treated with Rabeprazole Sodium Enteric Coated Capsules. All patients received 4 weeks of treatment. The changes of clinical efficacy, TCM syndrome scores, gastroscopy scores and pathological test scores were observed before and after treatment.Results①The total effective rate of the treatment group was 92.68%, while that of the control group was 73.17% (P<0.05). The curative effect of the treatment group was better than that of the control group (P<0.05). ②The TCM syndrome scores of spleen and stomach damp-heat syndrome in the two groups were lower than those before treatment respectively, and the differences were statistically significant (P<0.05). After treatment, the TCM syndrome scores of the treatment group was significantly lower than the scores of the control group (P<0.05). ③After treatment, the scores of gastroscopy and pathological test of the treatment group were higher than those of the control group (P<0.05).ConclusionQinghua Hezhong Decoction is safe and effective in treating chronic non-atrophic gastritis with spleen and stomach damp-heat syndrome.关键词：chronic non-atrophic gastritis;spleen and stomach damp-heat syndrome;Qinghua Hezhong Decoction;clinical trial
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发布时间：2022-08-03 - 摘要：ObjectiveTo observe the clinical effect of Tiaozang Shumi Decoction in the treatment of chronic constipation of deficiency syndrome.MethodsTotally 254 patients with chronic constipation of deficiency syndrome were randomly divided into control group (n=127) and treatment group (n=127). Control group was treated with permeable cathartic (Polyethylene Glycol Electrolytes Powder Ⅳ), and treatment group was treated with Tiaozang Shumi Decoction, and the two groups were continuously treated for 2 weeks. The clinical effect was observed, and scores of the main constipation symptoms and State-Trait Anxiety Inventory (STAI) were compared.Results①The short-term and long-term effects in the treatment group were superior to those in the control group (P<0.05). ②After treatment and 2 weeks after drug withdrawal, the scores of fecal characteristics, laborious defecation, defecation time, straining at stool and decreased force of urination, defecation frequency and abdominal distension in the two groups were all lower than those before treatment (P<0.05). There were no significant differences in the scores of constipation symptoms in the treatment group 2 weeks after drug withdrawal compared with those after treatment (P>0.05), and the scores of fecal characteristics, laborious defecation, defecation time, straining at stool and decreased force of urination, defecation frequency and abdominal distension in the control group increased (P<0.05). After treatment and 2 weeks after treatment, the scores of constipation symptoms in the treatment group were lower than those in the control group (P<0.05). ③The scores of State Anxiety Inventory (S-AI) and Trait Anxiety Inventory (T-AI) of STAI decreased in both groups after treatment (P<0.05). The scores of S-AI and T-AI in the treatment group were lower than those in the control group after treatment (P<0.05). ④During the treatment, no obvious adverse reactions occurred in both groups.ConclusionCompared with Polyethylene Glycol Electrolytes Powder Ⅳ, Tiaozang Shumi Decoction has a more satisfactory therapeutic effect on chronic constipation of deficiency syndrome, and it can better improve the clinical symptoms and adverse psychological emotions of patients with lasting effect and good safety.关键词：chronic constipation;deficiency syndrome;Tiaozang Shumi Decoction;anxiety;depression
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发布时间：2022-08-03 - 摘要：ObjectiveTo observe the clinical effect of Xinqingkai Decoction on chronic HBV infection-induced liver cirrhosis complicated with mild hepatic encephalopathy (MHE).MethodsSixty-eight patients with chronic HBV infection-induced liver cirrhosis complicated with MHE were randomly divided into prevention and treatment group (n=34) and control group (n=34). On the basis of routine treatment of antivirus and liver protection, as well as symptomatic support treatment, the prevention and treatment group was administered with Xinqingkai Decoction orally, while the control group was administered with Lactulose Oral Solution. The course of treatment in both groups was 30 days. The clinical prognosis of the two groups was observed, and the changes of neuropsychological test indexes (NCT-A, DST), related biochemical indexes [alanine aminotransferase (ALT), aspartate aminotransferase (AST), albumin (A), blood ammonia and endotoxin in liver function] and microbiological quantitative analysis indexes of intestinal microbiota were compared before and after intervention.Results①A total of 64 cases completed the experiment, 33 cases in the prevention and treatment group and 31 cases in the control group. ②There were significant differences in NCT-A and DST levels before and after treatment within both groups. NCT-A levels reduced significantly and DST levels increased significantly after treatment (P<0.05); After treatment, the improvement of NCT-A and DST levels in the prevention and treatment group was significantly better than that in the control group (P<0.05). ③There were significant differences in levels of ALT, AST, albumin, blood ammonia and endotoxin before and after treatment within two groups. The levels of ALT, AST, blood ammonia and endotoxin decreased significantly and the level of albumin increased significantly (P<0.05); After treatment, the improvement of ALT, AST, albumin, blood ammonia and endotoxin levels in the prevention and treatment group was significantly better than that in the control group (P<0.05). ④The levels of Escherichia coli, Enterococcus faecalis, Bifidobacterium and Lactobacillus were significantly different before and after treatment within the two groups. The levels of Escherichia coli decreased significantly, while the levels of Enterococcus faecalis, Bifidobacterium and Lactobacillus increased significantly (P<0.05). After treatment, the level of Escherichia coli in the prevention and treatment group was significantly lower than that in the control group, and the level of Bifidobacterium was significantly higher than that in the control group (P<0.05). ⑤ After the course of treatment, no case was found turning into clinical hepatic encephalopathy in both groups. The recovery rate of the two groups was 27.3% and 6.5%, respectively, and the recovery rate was significantly higher in the prevention and control group than that in the control group (P<0.05).ConclusionXinqingkai Decoction has certain prevention and treatment effects on chronic HBV infection-induced liver cirrhosis complicated with MHE as it can better improve the cognitive ability, liver function, blood ammonia and endotoxin levels, regulate intestinal microbiota and improve the clinical outcome.关键词：Xinqingkai Decoction;mild hepatic encephalopathy;chronic HBV infection-induced liver cirrhosis;clinical prognosis;intestinal microbiota;hepato-intestinal circulation;Wang Lingtai
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发布时间：2022-08-03 - 摘要：ObjectiveTo observe the clinical effect of Jinhuang Powder in the treatment of acute stage of erysipelas in the lower extremities.MethodsOne hundred acute erysipelas patients were randomly divided into internal and external treatment group with traditional Chinese medicine and Western medicine treatment group. The course of treatment in both groups was 14 days. The clinical effect and the improvement of local symptoms were observed.ResultsThe total effective rates of the treatment group and the control group were 91.67% and 69.38% respectively. The difference of the above two groups was statistically significant (P<0.05). After treatment, there was a significant difference in the total score of local symptoms between the treatment group and the control group (P<0.05).ConclusionHoop therapy combined with Puding mixture is effective in the treatment of acute erysipelas in lower extremities.关键词：hoop encirclement method;Puding mixture;lower extremity erysipelas;internal and external treatment of traditional Chinese Medicine
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发布时间：2022-08-03 - 摘要：ObjectiveTo observe the effect of Shenshuai Ⅱ Decoction on chronic kidney diseases (CKD) 3-4 patients with mild-to-moderate proteinuria.MethodsA total of 88 patients of CKD3-4 stages with mild-to-moderate proteinuria were randomly divided into control group (44 cases) and treatment group (44 cases). On the basic treatment, the treatment group was treated with Shenshuai Ⅱ Decoction, and the control group was treated with Niaoduqing Granule. The course of treatment in both groups was 6 months. The clinical efficacy and TCM symptom score, renal function (Scr, BUN, eGFR), urine protein (24hUpro, URBP, Uα1-MG, Uβ2-MG)were observed. Results①The total effective rate was 86.36% in the treatment group and 61.36% in the control group, and the clinical efficacy in the treatment group was better than that in the control group(P<0.05). ②After treatment, the single scores and the total scores of TCM symptoms in the treatment group were significantly decreased (P<0.05), while those in the control group were significantly decreased except dark complexion, nausea and vomiting (P<0.05). Except dry mouth and bitter mouth, the single scores and the total scores of TCM symptoms in the treatment group were lower than those in the control group (P<0.05).③After treatment, the levels of Scr and BUN were significantly decreased, and the eGFR level was significantly increased in the treatment group (P<0.05). In the control group, the level of Scr was significantly decreased (P<0.05). The level of BUN was lower in the treatment group than that in the control group (P<0.05). ④After treatment, the levels of 24hUpro, Uβ 2-MG, Uα 1-MG and URBP significantly decreased in the treatment group (P<0.05), while 24hUpro and Uα1-MG decreased significantly in the control group (P<0.05). The levels of Uβ 2-MG, Uα 1-MG and URBP were lower in the treatment group than those in the control group(P<0.05).ConclusionShenshuai Ⅱ Decoction has better clinical efficacy than Niaoduqing Granule in the treatment of CKD3-4 patients with mild-to-moderate proteinuria, which significantly improves TCM symptoms and renal function, reduces the level of tubular proteinuria, and delays the progression of CKD.关键词：chronic kidney disease;Shenshuai Ⅱ Decoction;proteinuria;renal function;clinic trial
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发布时间：2022-08-03 - 摘要：ObjectiveTo study the protective effect of echinacoside on diabetic rats with renal injury by sirt1/FOXO1 pathway.MethodsDiabetic renal injury rats were randomly divided into three groups: model group, echinacoside, EX527, and echinacoside-EX527 with 12 rats in each group. Other 12 SD rats were selected as the control group. Furthermore, serum creatinine (Scr) , serum uric acid (SUA) and urinary microalbumin (UMA) were measured by automatic biochemical analyzer. HE staining was used to detect the pathological morphology of renal tissue. Superoxide dismutase (SOD) test kit and malondialdehyde (MDA) test kit were used to detect the levels of SOD and MDA in renal tissue. The levels of tumornecrosis factor-α (TNF-α) and interleukin-6 (IL-6) in serum of rats were detected by enzyme-linked immunosorbent assay (ELISA) . The expression of sirt1/FOXO1 pathway related protein was detected by Western blot.ResultsCompared with the control group, the renal glomerulus volume and mesangial matrix of rats in the model group were increased, and the renal tubules were swollen and necrotic with vacuolized degeneration and inflammatory infiltration. In addition, the content of SOD and the expression of sirt1 in renal tissue decreased (P<0.01) , while Scr, SUA, UMA, levels of serum TNF-α and IL-6, content of MDA in renal tissue and acely FOXO1/FOXO1 were all increased (P<0.01) . Compared with the model group, the pathological damage of renal tissue in the echinacoside group was reduced, and the content of SOD and the expression of sirt1 in renal tissue increased (P<0.01) . Besides, Scr, SUA, UMA, levels of serum TNF-α and IL-6, content of MDA in renal tissue and acely FOXO1/FOXO1 were decreased (P<0.01) . In the EX527 group, the pathological damage of renal tissue was aggravated, and the content of SOD and the expression of sirt1 in renal tissue decreased (P<0.01) . Moreover, Scr, SUA, UMA, levels of serum TNF-α and IL-6, content of MDA in renal tissue and acely FOXO1/FOXO1 were increased (P<0.01) . Compared with the echinacoside group, the renal pathological damage of the echinacoside-EX527 group was aggravated. The content of SOD and the expression of sirt1 in renal tissue decreased (P<0.01) . Scr, SUA, UMA, levels of serum TNF-α and IL-6, content of MDA in renal tissue and acely FOXO1/FOXO1 were increased (P<0.01) . Compared with EX527 group, the pathological damage of kidney tissue of rats in echinacoside-EX527 group was alleviated, and the content of SOD and the expression of sirt1 in renal tissue were increased (P<0.01) . Additionally, Scr, SUA, UMA, levels of serum TNF-α and IL-6, content of MDA in renal tissue and acely FOXO1/FOXO1 decreased (P<0.01) .ConclusionEchinacoside may inhibit oxidative stress and inflammation by activating the sirt1/FOXO1 pathway to reduce diabetic renal injury.关键词：echinacoside;diabetes mellitus;renal injury;sirt1/FOXO1 pathway;rat
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发布时间：2022-08-03 - 摘要：ObjectiveTo observe the effect of Bushen Huoxue Formula on VEGFA, VEGFR2 and PI3K/Akt signal transduction pathway in decidua of recurrent abortion mice, and to explore the possible mechanism of Bushen Huoxue Formula in treating recurrent abortion.MethodsBALB/c × CBA/J normal pregnant mice model and DBA/2 × CBA/J recurrent abortion mice model were established. The mice were randomly divided into normal group, model group, progesterone group (3.33 mg/kg), and Bushen Huoxue Formula low-dose (10.47 g/kg), medium-dose (20.93 g/kg) and high-dose (41.87 g/kg) groups. Each group was given corresponding drugs by gavage for 2 weeks. The embryo loss rate of CBA/J mice after different concentrations of drug intervention was observed; the expressions of VEGFA and VEGFR2 proteins in decidua were detected by immunohistochemistry; the expressions of VEGFA, VEGFR2, PI3K, Akt, p-Akt proteins in decidua were detected by Western blot.Results①Compared with the model group, the embryo loss rates of the progesterone group and the low-dose, medium-dose and high-dose groups of Bushen Huoxue Formula were significantly decreased (P<0.05). ②The results of immunohistochemistry showed that: compared with the model group, the positive expression of VEGFA protein was increased in the progesterone group, and the medium-dose and high-dose groups of Bushen Huoxue Formula; the positive expression of VEGFR2 protein was increased in the progesterone group and the low-dose, medium-dose and high-dose groups of Bushen Huoxue Formula (P<0.05); compared with the low-dose group of Bushen Huoxue Formula, the positive expression of VEGFA protein in the medium-dose and high-dose groups of Bushen Huoxue Formula was increased (P<0.05). ③Western blot results showed that: compared with the model group, the expressions of VEGFA, VEGFR2, PI3K, p-Akt proteins in the progesterone group, and the low-dose, medium-dose and high-dose groups of Bushen Huoxue Formula were significantly increased (P<0.05); compared with low-dose and medium-dose groups of Bushen Huoxue Formula, the protein expressions of VEGFA, VEGFR2, PI3K and p-Akt in the high-dose group of Bushen Huoxue Formula were significantly increased (P<0.05).ConclusionBushen Huoxue Formula can up-regulate the expression of VEGFA and VEGFR2 in decidua of recurrent abortion model mice, and the mechanism may be related to the activation of PI3K/Akt signaling pathway.关键词：Bushen Huoxue Formula;recurrent abortion;mice;decidual tissue;VEGF;PI3K/Akt
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发布时间：2022-08-03 - 摘要：Research progress on pharmacological effects of silibinin is reviewed.Studies have confirmed that silibinin has various pharmacological activities, such as anti-tumor, liver protection, heart protection, antibiosis, etc.Silibinin has a good clinical application prospect, which can inhibit the growth of cancer cells through regulating kinase, transcription factors and cell signaling pathways, thereby showing significant inhibitory effects on liver cancer, gastric cancer, lung cancer, breast cancer, ovarian cancer, prostate cancer and so on. It has good prospect in clinical application.关键词：silibinin;pharmacological activities;anti-tumor;review
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- 1624
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发布时间：2022-08-03 - 摘要：This paper reviews the research progress of the pharmacological effects of ginsenoside Rh3 in recent years. Ginsenoside Rh3 has a variety of pharmacological activities, including anti-tumor, anti-oxidation, anti-inflammatory, anti-apoptosis, neuroprotection etc. It plays a significant protective role in several kinds of diseases (such as colorectal cancer, ovarian cancer, leukemia, retinal degeneration, postpartum uterine bleeding, myocardial ischemia-reperfusion injury, renal chemotherapy injury, chronic dermatitis, ultraviolet-induced skin disease, Alzheimer's disease, and so on) and shows lower chemical toxicity with the possibility to be deeply researched and developed.关键词：ginsenoside Rh3;anti-tumor;anti-inflammatory;anti-oxidation;anti-apoptosis;neuroprotection;intestinal microflora;review
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- 1207
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发布时间：2022-08-03 - 摘要：Solanumnigrum L.is a Chinese medicine commonly used in tumor treatment, which contains a variety of anti-tumor active ingredients, such as solanine, solamargine, solaoiacid, solasonine, solasodine, degalactotigonin, quercetin, diosgenin and so on.It can be used to treat gastric cancer, lung cancer, colorectal cancer, breast cancer, bladder cancer, liver cancer, osteosarcoma, prostate cancer and other malignant tumors.Its anti-tumor mechanisms include inhibition of proliferation and growth, arrest of cell cycle, induction of apoptosis, inhibition of epithelial-stromal transformation and metastasis, reversal of drug resistance, enhancement of radiotherapy, chemotherapy and targeted therapy.关键词：Solanumnigrum L.;active ingredients;antitumor effects;mechanism;review
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- 1407
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发布时间：2022-08-03
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