最新刊期
期 11 ， 2021
- 摘要：The purpose of this paper is to introduce professor Huang Huang’s experience in differential diagnosis and treatment of gastrointestinal diseases with classical formulas. Most of the prescriptions prescribed by professor Huang can be elucidated by the contents of classics. He pays attention to the indications of each prescription, emphasizes the adjustment of patients’ physique and emotion, focuses on the addition and subtraction of prescriptions and the use of combined prescriptions, and pays attention to the time and methods of taking medicine. And one proven case is presented.关键词：gastrointestinal diseases;classic formulas;correspondence between prescription and syndrome;Huang Huang;traditional Chinese medicine therapy
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发布时间：2022-08-03 - 摘要：Through the review of ancient Chinese medicine books and modern medical literatures, this paper summarizes and sorts out the dorsal manifestations related to gastroesophageal reflux disease (GERD), and analyzes their pathogenesis. The dorsal manifestations of GERD include pain, cold or heat sensation and distension between the scapulae, as well as the tenderness, skin temperature and morphological changes at the acupoints of Governor Channel and (or) bladder meridian in this area. The pathogenesis can be interpreted based on the regulation of visceral and somatosensory innervation in the western medicine and the related theory of meridians and zang-fu viscera in traditional Chinese medicine. The study of dorsal manifestations of GERD would help to improve the understanding of clinical practitioners on GERD, so as to reduce misdiagnosis and mistreatment.关键词：gastroesophageal reflux disease;extraesophageal symptom;back pain;tenderness;dorsal syndrome of gastroesophageal reflux disease
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发布时间：2022-08-03 - 摘要：ObjectiveTo analyze the tongue image features of patients with ulcerative colitis (UC) and explore the relationship between the tongue images and the colonoscopic features based on image data processing. MethodsA total of 226 confirmed UC patients and 45 health people were selected as study subjects. The tongue image indexes of all study subjects were collected and analyzed by TDA-1 tongue diagnosis instrument and TDAS 2.0 Chinese medical tongue diagnosis analysis system, the colonoscopy reports of UC patients were also compiled and recorded, and the tongue image characteristics and the correlation between colonoscopic features and tongue images were analyzed.ResultsThe tongue image indexes indicated that UC patients especially those with intestinal lesions had redder, more purplish-red, bluer tongue bodies and more yellowish, greasier tongue coatings than the health people. The UC patients with intestinal lesions showed redder, more purplish-red, bluer tongue bodies and more yellowish, greasier tongue coatings than those without lesions recently, but the differences between different locations of intestinal lesions were not significant. As to the degree of congestion and edema, those with intestinal diffuse hyperaemia had redder, more purplish-red tongue bodies and more yellowish, greasier tongue coatings than patients with other types. As to the degree of mucosal frangibility, pus secretion and spontaneous bleeding, the UC patients with intestinal frangibility-positive, pus-positive and spontaneous bleeding-positive had redder, more purplish-red tongue bodies, more yellowish and greasier tongue coatings than those negative individuals. As to the degree of mucosal ulceration, those with mucosal ulceration had redder, more purplish-red tongue bodies and greasier tongue coatings than those without ulceration, and those with diffuse colonic ulcer had more yellowish and greasier tongue coatings than those with other types of UC. The closer the grade between the degrees of ulceration was, the less significant the differences would be, but the overall trend showed that the more severe the degree of ulceration was, the more reddish, purplish-red the tongue bodies and the more yellowish, greasier the tongue coatings would be. Correlation analysis showed that the more severe the degree of intestinal mucosal hyperaemia, frangibility, ulceration, pus secretion, and spontaneous bleeding was, the more reddish and purplish-red the tongue bodies and the more yellowish and greasier the tongue coatings would be; the more extensive the lesion was, the more reddish and purplish-red the tongue bodies and the greasier the tongue coatings would be.ConclusionsPatients with UC are more likely to have red, purplish-red, blue tongue bodies and yellowish greasy tongue coatings compared to healthy individuals. There is a correlation between tongue images and colonoscopic features in UC patients; the more severe the colonoscopic manifestations are, the more reddish and purplish-red the tongue bodies and the more yellowish greasier the tongue coatings would be.关键词：ulcerative colitis;tongue image;colonoscopic feature;image data processing
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发布时间：2022-08-03 - 摘要：ObjectiveTo explore the fecal metabolomic characteristics of children with rotavirus enteritis of damp-heat syndrome from the perspective of metabolomics.MethodsFecal samples were collected from 20 children with rotavirus enteritis (RV damp-heat syndrome group) and 20 healthy children, ultra-high performance liquid chromatography coupled with quadrupole-exactive high resolution mass spectrometry (UHPLC-Q Exactive HRMS) was utilized to collect fecal metabolic fingerprints, and orthogonal-partial least squares discriminant analysis (OPLS-DA) pattern recognition approach was introduced for data analysis to identify differential endogenous metabolites.ResultsOPLS-DA pattern recognition approach can effectively distinguish RV damp-heat syndrome group from healthy group with high reliability. Eleven differential metabolites were screened out and identified, involving 9 metabolic pathways, such as caffeine metabolism, nicotinate and nicotinamide metabolism, porphyrin and chlorophyll metabolism, unsaturated fatty acid metabolism, arachidonic acid metabolism, arginine and proline metabolism, pyrimidine metabolism, tryptophan metabolism, and glycine, serine and threonine metabolism.ConclusionThere are differential metabolites in fecal samples between children with rotavirus enteritis of damp-heat syndrome and healthy children. The abnormal expression of these metabolic compounds may be an important pathogenesis of rotavirus enteritis of damp-heat syndrome, and it can also be a potential intervention target.关键词：rotavirus enteritis;damp-heat syndrome;metabolomics;UHPLC-Q-Exactive HRMS
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发布时间：2022-08-03 - 摘要：ObjectiveTo explore the relationship between functional bowel disorder (FBD) and anxiety and depressive states in patients with epilepsy and the distribution of traditional Chinese medicine (TCM) syndromes. MethodsA total of 306 patients with epilepsy were divided into the group with FBD (n=172) and the group without FBD (n=134) according to the disease status of FBD. The case data were collected and analyzed to compare the general conditions (gender, age, disease duration, EEG, cognitive function), Self-rating Anxiety Scale (SAS) scores, Self-rating Depression Scale (SDS) scores and the distribution of TCM symptoms between the two groups. Logistic regression was used to analyze the factors influencing FBD in epileptic patients.Results①Compared with the conditions in the group without FBD, the age was higher, the disease duration was longer and the EEG abnormality rate was higher in the group with FBD (P<0.001, P<0.05). ②SAS and SDS scores were higher in the group with FBD than the scores in the group without FBD (P<0.001), and the abnormal rates of SAS and SDS scores were higher than those in the group without FBD (P<0.001). ③According to the results of logistic regression analysis, the disease duration, age, and SAS scores were influencing factors of FBD in epileptic patients (P<0.05), and epileptic patients with abnormal SAS scores were 6.104 times more likely to have FBD than those with normal SAS scores [OR=6.104, 95% CI (3.416-10.906), P<0.001]. ④The heart and spleen dual deficiency syndrome was the most common syndrome in the group with FBD (27.91%), and the stasis blocking brain collaterals syndrome was most common syndrome in the group without FBD (41.79%). The distribution of TCM syndromes of phlegm, deficiency and stasis showed that most cases in the group with FBD had deficiency syndomes (44.19%) and most cases in the group without FBD had phlegm syndromes (52.24%).ConclusionCompared with conditions in the group without FBD, epileptic patients with FBD had more severe anxiety and depression. The disease duration, age, and anxiety and depressive states are all influencing factors in the occurrence of FBD in patients with epilepsy. Epileptic patients with FBD are more likely to have deficiency syndromes, and the heart and spleen dual deficiency syndrome has the highest proportion.关键词：epilepsy;functional bowel disorder;anxiety state;depressive state;traditional Chinese medicine syndrome
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发布时间：2022-08-03 - 摘要：ObjectiveTo explore the medication rules of retention enema with traditional Chinese medicine (TCM) in treating anal sinusitis based on the ancient and modern medical case cloud platform (V2.3.8). MethodsRelated literatures of retention enema with TCM in the treatment of anal sinusitis published from the establishment of the databases to March 4, 2021 were retrieved from CNKI, VIP, WanFang Data, VIP, China Biomedical Literature Service Platform (CBM). A database of traditional Chinese medicine prescriptions was established based on the ancient and modern medical case cloud platform (V2.3.8). The "data mining analysis" module was used for the analysis of traditional Chinese herbal medicines (TCHMs) use frequency, nature, taste, tropism and correlation rules, and the "multidimensional analysis" module was used for the core drug analysis and cluster analysis.Results①Finally 58 articles were included, involving 58 prescriptions and 108 TCHMs. ②TCHMs with high use frequency were Phellodendron chinense Schneid, Coptis Rhizoma, Rhei Radix et Rhizoma, Sophorae Flavescentis Radix and Lonicerae Japonicae Flos, which have cold and warm properties, bitter, pungent and sweet tastes, and enter the liver, stomach, heart, spleen, large intestine and lung meridians. ③Fourteen TCHM combinations were obtained through correlation analysis, and the TCHM pairs with high use frequency were Sophorae Flavescentis Radix-Phellodendron chinense Schneid, Lonicerae Japonicae Flos-Phellodendron chinense Schneid, and Sanguisorbae Radix-Phellodendron chinense Schneid. ④The core medication network was composed of 18 TCHMs, and the core compatibility network was composed of 2 groups of TCHMs. There were 3 categories of TCHMs obtained through cluster analysis.ConclusionThe application of retention enema with TCM to the treatment of anal sinusitis stresses the combined use of cold and warm medicines, and simultaneous regulation of the liver and spleen. The TCHMs used are mainly heat-clearing and detoxifying medicinals, heat-clearing and dampness-drying medicinals, heat-clearing and blood-cooling medicinals, and blood-activating and pain-relieving medicinals, reflecting the pathological characteristics of anal sinusitis: "dampness, heat, toxicity and stasis" .关键词：anal sinusitis;retention enema with traditional Chinese medicine;data mining;ancient and modern medical case cloud platform
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发布时间：2022-08-03 - 摘要：This article presents Professor Yang Wei’s clinical experience in treating high complex anal fistulas with the high loose seton-gradually close thread therapy. It is believed that the traditional seton therapy is highly traumatic and has a certain impact on the function of the anus. Based on the concept of protecting the function of the anal sphincter, and guided by the concept of minimally invasive surgery, Professor Yang has created the high loose seton-gradually close thread therapy considering the characteristics of high anal fistula with large abscess cavity, high internal opening, deep fistula and many branches. The high loose seton-gradually close thread therapy is not only clinically effective but also has few complications. One proven and effective case is attached.关键词：high complex anal fistula;seton therapy;anal sphincter;anal function;Yang Wei
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发布时间：2022-08-03 - 摘要：The purpose of this paperis to introduce Professor Liu Chenghai’s experience in treating chronic liver diseases with herbal paste. Taking the combination of diseases and symptoms as well as mutual participation of Chinese and Western medicine as the basic principle, the treatment is mainly based on reinforcing healthy qi and resolving stasis, supplemented by tonifying and replenishing the liver and kidney, regulating qi and harmonizing the stomach, enriching yin and clearing heat, removing toxin and disinhibiting dampness, beware of using drugs with toxins, which is the method of treating both the tip and root and treating with both elimination and reinforcement. And one proven case is presented.关键词：chronic liver disease;reinforcing healthy qi and resolving stasis;herbal paste;Liu Chenghai;traditional Chinese medicine therapy
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发布时间：2022-08-03 - 摘要：From the aspects of the origin of the disease name, onset of the disease, etiology and pathogenesis, syndrome differentiation and treatment, this paper introduces professor Qi Baoyu’s clinical experience in the treatment of children’s morbid blinking. It is considered that because of the characteristics of "spleen is often insufficient and liver often excessive" , coupled with the character of introvert, timidity or irritability, children are more likely to appear the morbid blinking due to liver wind stirring inside, which is treated clinically from the liver and spleen, such as fortifying the spleen and emolliating the liver, releasing convulsion and extinguishing wind. And one proven case is presented.关键词：morbid blinking;abnormal blink syndrome;pediatric eye diseases;fortifying the spleen and emolliating the liver;Qi Baoyu;traditional Chinese medicine therapy
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发布时间：2022-08-03 - 摘要：Wang Xiafang pays special attention to regulating qi movement in the treatment of pediatric diseases, emphasizing that the spleen and stomach is the hub of qi movement. In the early stage of the disease, it is treated by the method of unblocking qi movement, and in the late stage of the disease, it is treated by the unblocking qi movement as supplement method. The method of regulating the qi movement is used throughout the treatment course. And the proven cases of common diseases such as attention deficit hyperactivity disorder, recurrent respiratory tract infection and anorexia are presented.关键词：pediatric diseases;attention deficit hyperactivity disorder;recurrent respiratory tract infection;anorexia;regulating qi movement;traditional Chinese medicine therapy
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发布时间：2022-08-03 - 摘要：Modern doctors treat coronary heart disease mainly by activating blood and resolving stasis or resolving phlegm and unblocking collaterals. However, heart yang also plays an important role in the treatment of heart disease or even in angina pectoris. The pathogenesis of coronary heart disease is closely related to heart yang deficiency syndrome. Zhang Zhongjing put forward the theory of " weak pulse at yang and wiry pulse at yin" in the treatment of angina pectoris and treated it based on the method of warming and unblocking the heart yang as well as the dynamic syndrome differentiation and treatment thought of treating heart-lung, heart-spleen and heart-kidney, which also has certain enlightenment value for the diagnosis and treatment of coronary heart disease today.关键词：coronary heart disease;heart yang;Zhang Zhongjing;weak pulse at yang and wiry pulse at yin;syndrome differentiation and treatment
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发布时间：2022-08-03 - 摘要：ObjectiveTo observe the clinical efficacy of Zhu’s Tiaojing Recipe in treating premature ovarian insufficiency (POI) patients with type of kidney deficiency and blood stasis and its ameliorative effect on ovarian blood supply.MethodsOne hundred and twenty-two POI patients with type of kidney deficiency and blood stasis were enrolled and randomly divided into the Chinese medicine group (60 cases) and the western medicine group (62 cases) . The patients in the Chinese medicine group were orally treated with Zhu’s Tiaojing Recipe, and the patients in the western medicine group were orally treated with estradiol tablets/estradiol and dydrogesterone tablets. The patients in both groups were continuously treated for 6 menstrual cycles. Before and after treatment, the peak systolic velocity (PSV) and resistance index (RI) of ovarian artery blood flow and the levels of serum follicle stimulating hormone (FSH) , luteinizing hormone (LH) , estradiol (E2) and anti-Müllerian hormone (AMH) were detected, the scores of Chinese medical syndrome in both groups were compared, and the efficacy of Chinese medical syndrome was evaluated.Results①After treatment, the RI of ovarian artery blood flow in the Chinese medicine group was significantly decreased compared with that before treatment (P<0.01) , and the PSV was significantly increased compared with that before treatment (P<0.01) ; the PSV of ovarian artery blood flow in the western medicine group was also increased compared with that before treatment (P<0.01) ; and the decrease range of ovarian artery blood flow RI in the Chinese medicine group was significantly greater than that in the western medicine group (P<0.05) . ②After treatment, the scores of Chinese medical syndrome in both groups were significantly decreased compared with those before treatment (P<0.01) , and the decrease range of Chinese medical syndrome score in the Chinese medicine group was higher than that in the western medicine group (P<0.01) . ③After treatment, the total effective rates on Chinese medical syndrome of the Chinese medicine group and the western medicine group were 88.33% and 69.35% respectively, and the therapeutic effect of the Chinese medicine group was better than that of the western medicine group (P<0.05) . ④After treatment, the levels of FSH in the two groups were significantly decreased compared with those before treatment (P<0.01) , and the levels of E2 and AMH were significantly increased compared with those before treatment (P<0.01, P<0.05) , but there were no statistically significant differences in the hormone levels between the two groups (P>0.05) .ConclusionZhu’s Tiaojing Recipe can effectively improve the clinical syndromes and serum sex hormone levels in POI patients with type of kidney deficiency and blood stasis, accelerate the PSV of ovarian artery blood flow and decrease the RI, thus improve the ovarian blood supply and provide the nutritional support for follicular growth.关键词：premature ovarian insufficiency;Zhu’s Tiaojing Recipe;type of kidney deficiency and blood stasis;ovarian blood supply;therapy of traditional Chinese medicine
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发布时间：2022-08-03 - 摘要：ObjectiveTo observe the effect of self-made Yiqi Jiedu Decoction combined with recombinant human interferon α-2b on the local microecological environment and related immune function indexes in patients with cervical persistent high-risk human papilloma virus (HPV) infection. MethodsA total of 64 patients with cervical persistent high-risk HPV infection were included and divided into the treatment group and control group according to the random number table, 32 cases in each group. The patients in the control group were treated with recombinant human interferon α-2b vaginal effervescent tablet, and the patients in the treatment group were orally treated with self-made Yiqi Jiedu Decoction based on the treatment of the control group. The treatment course of both groups was three months. The HPV negative change was compared between the two groups; the indexes of vaginal microecological environment were evaluated including the pH value of vaginal secretions and Nugent score, and the recovery rate of vaginal microecological environment was compared; the interferon-γ (IFN-γ), interleukin (IL)-4 and IL-12 levels of cervix were detected.Results①The total effective rate of HPV negative change was 87.5% in the treatment group and was 62.5% in the control group, and the HPV negative change in the treatment group was better than that in the control group (P<0.05). ②The recovery rate of vaginal microecological environment was 84.4% in the treatment group and was 46.9% in the control group, and the recovery of vaginal microecological environment in the treatment group was better than that in the control group (P<0.05); after treatment, the pH value of vaginal secretions and Nugent score in the two groups were significantly decreased compared with those before treatment (P<0.05), and the pH value of vaginal secretions and Nugent score in the treatment group were lower than those in the control group (P<0.05). ③After treatment, the IFN-γ and IL-12 levels of cervix in the two groups were significantly increased compared with those before treatment, the level of IL-4 was significantly decreased (P<0.05), and the levels of IFN-γ and IL-12 in the treatment group were higher than those in the control group (P<0.05) and the level of IL-4 was lower than that in the control group (P<0.05).ConclusionSelf-made Yiqi Jiedu Decoction combined with recombinant human interferon α-2b can effectively improve the local microecological environment of cervix and enhance the HPV negative rate and local immune function in the treatment of cervical persistent high-risk HPV infection.关键词：high-risk HPV infection;cervical cancer;self-made Yiqi Jiedu Decoction;recombinant human interferon α-2b;local microecological environment;immune index
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发布时间：2022-08-03 - 摘要：ObjectiveTo research the effect of acupuncture and moxibustion with Chinese medicine in regulating the estrogen receptor in endometriosis.MethodsFifty SD rats were randomly divided into sham operation group, model group, acupuncture and moxibustion group, Chinese medicine group, acupuncture and moxibustion with Chinese medicine group (AC group in brief), 10 rats in each group. Endometriosis rat models were established in advance. The acupuncture and moxibustion group received acupuncture at Xuehai (SP10) and Sanyinjiao (SP6) and moxibustion at Guanyuan (CV4); the Chinese medicine group was treated with 0.9% NaCl suspension of Jiawei Mojie tablet by oral gavage; the AC group was treated by the above two methods simultaneously. The sham operation group and the model group were fixed and given of the same dosage of 0.9% NaCl by oral gavage. After 30 days of treatment, the diameters of ectopic cysts in five groups were measured. Normal endometrial, eutopic and ectopic endometrial tissues were taken for immunohistochemical detection and the expressions of estrogen receptor α (ERα) and estrogen receptor β (ERβ) in different tissues were compared.ResultsThe diameter of ectopic cyst in acupuncture and moxibustion group, Chinese medicine group, and AC group was significantly smaller than that in model group (P<0.05). The diameter of ectopic cyst in AC group was significantly smaller than that both in acupuncture and moxibustion group and Chinese medicine group (P<0.05). The ERα expression in ectopic and eutopic endometrium of acupuncture and moxibustion group and AC group was significantly higher than that of model group (P<0.01) and Chinese medicine group (P<0.01). The ERα expression in eutopic endometrium of AC group was higher than that of acupuncture and moxibustion group (P<0.05). The ERβ expression in ectopic and eutopic endometrium of acupuncture and moxibustion group, Chinese medicine group and AC group was lower than that of model group (P<0.01). The ERβ expression in ectopic and eutopic endometrium of AC group was significantly lower than that of Chinese medicine group (P<0.01). ERα/ERβ ratio was lower in the ectopic and eutopic endometrium of EMS rats. ERα/ERβ ratio in the ectopic and eutopic endometrium of AC group was the highest among all the groups.ConclusionThe combination of acupuncture and moxibustion with Chinese medicine may achieve the treatment effect of rats’ endometriosis through up-regulating the expression of ERα protein and down-regulating the expression of ERβ protein in eutopic and ectopic endometrium to the normal level.关键词：endometriosis;acupuncture and moxibustion with Chinese medicine;estrogen receptor α;estrogen receptor β
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发布时间：2022-08-03 - 摘要：ObjectiveTo observe the effect of estrogen receptor antagonist on the neuroprotective effect of Zuoguiwan Decoction, and explore the material basis of the theory of "kidney-brain connection" in traditional Chinese medicine.MethodsA total of 108 female SD rats were randomly divided into 6 groups: sham operation group (group a), simple cerebral ischemia group (group b), panic injuring kidney group (group c), Chinese medicine kidney-tonifying group (group d), estrogen receptor antagonist group (group e), Naofukang group (group f), with 18 rats in each group. The middle cerebral artery occlusion (MCAO) model of rats was established by thread occlusion in all groups except sham operation group. Rats in group c, group d, group e and group f were threatened by high platform 10 days before MCAO. Rats in group d and group e were administered with Zuoguiwan Decoction 1.62 g/kg by gavage 3 days before MCAO, once a day for 10 consecutive days. Rats in group f were administered with Naofukang suspension 0.324 g/kg by gavage 3 days before MCAO, once a day for 10 consecutive days. Rats in group e were also administered with the estrogen receptor blocker ICI182780 5 mg/kg intraperitoneally 3 days before MCAO, once a day for 10 consecutive days. The motor ability of rats in each group was measured by a horizontal beam method, the memory of rats was measured by a novel cognition method and platform jumping test, and the morphological changes of brain tissue were observed by HE staining method.ResultsCompared with group a, there was a significant decrease of the motor ability and memory of rats in group b (P<0.01); compared with group b, there was a significant decrease of the motor ability and memory of rats in group c (P<0.05); compared with group c, there was a significant improvement of the motor ability and memory of rats in group d (P<0.05); compared with group d, there was a significant decrease of the motor ability and memory of rats in group e (P<0.05); compared with group d, there was no significant difference of the motor ability and memory of rats in group f (P>0.05).ConclusionThe protective effect of Zuoguiwan Decoction on brain can be blocked by estrogen receptor antagonists, suggesting that Zuoguiwan Decoction can affect brain through estrogen and its receptors, and "kidney-estrogen and its receptors-brain" may be one of the key pathways of "kidney communicating with the brain" .关键词：kidney-brain connection;estrogen;Zuoguiwan Decoction;MCAO;estrogen receptor antagonist;model rats;traditional Chinese herbal medicine research
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发布时间：2022-08-03 - 摘要：ObjectiveTo explore the effect of Xiaonang Culuan Wan (XCW) on the levels of sex hormones in rats with polycystic ovary syndrome and its related mechanism of action.MethodsOf 90 six-week-old SPF female SD rats, 15 were randomly selected as normal group (intragastric administratiion of 0.9% NaCl solution). After successful establishment of polycystic ovary syndrome model, the remaining rats were randomly divided into model group (intragastric administratiion of 0.9%NaCl solution), positive drug group (intragastric administratiion of 270 mg/kg metformin), low-dose group (intragastric administratiion of 3.15 g/kg XCW), medium-dose group (intragastric administratiion of 6.30 g/kg XCW) and high-dose group (intragastric administratiion of 12.60 g/kg XCW), with 15 rats in each group. After successful modeling, each group was given drug intervention for 12 days. The histopathological changes of rats in each group were observed, and the levels of fasting insulin (FINS), fasting plasma glucose (FPG), 2-h postprandial insulin (2 h INS), 2-h postprandial glucose (2 h PG), C-reactive protein (CRP), interleukin 6 (IL-6), tumor necrosis factor -α (TNF-α) 、testosterone (T), estradiol (E2), luteinizing hormone (LH), follicle stimulating hormone (FSH) and the expression of AKT-2, GSK-3β、 IRS-1, GLUT-4, PTEN mRNA in ovarian tissue were detected, which were used to analyze the mechanism and the effect of XCW on sex hormone levels in rats with polycystic ovary syndrome.ResultsCompared with the model group, the results of intraperitoneal glucose tolerance test (IPGTT) and levels of inflammatory factors, T, E2, LH and PTEN mRNA expression in the high-dose group, medium-dose group, low-dose group and positive drug group showed lower (P<0.05); Compared with the model group, the level of FSH and levels of AKT-2, GSK-3β, IRS-1 and GLUT-4 mRNA expression in the high-dose, medium-dose, low-dose and positive drug groups were higher (P<0.05), and the effect of high-dose group were the best.ConclusionBy acting on P13K/AKT signal pathway, XCW can promote sexual function and reduce inflammation maybe through up-regulating the expression of AKT-2, GSK-3β, IRS-1, GLUT-4 mRNA and down-regulating the expression of PTEN mRNA.关键词：Xiaonang Culuan Wan;polycystic ovary syndrome;sex hormones;mechanism of action;model rats;traditional Chinese herbal medicine research
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发布时间：2022-08-03 - 摘要：ObjectiveTo explore the effect and mechanism of Danshen Yin on lipid metabolism in rats with hyperlipidemia induced by long-term feeding with high-fat diet.MethodsTotally 70 Wistar rats were randomly divided into basic group (n=14 ) and high-fat group (n=56 ). The rats in the basic group were fed with basic diet, and the rats in the high-fat group were fed with high-fat diet. The blood lipid level of the animals was measured in the eighth week. The rats in the basic group met the requirements were taken as the blank group. According to body weight and blood lipid levels, the successful modeling rats in the high-fat group were randomly divided into model group, simvastatin control group (0.004 g/kg ), high-dose Danshen Yin group (3.6 g/kg crude drug ) and low-dose Danshen Yin group (0.9 g/kg crude drug). Four weeks after administration, the blood lipid biochemical indexes (TC, TG, HDL-C, LDL-C) and the levels of lipid metabolic enzymes (HL, LCAT, PLTP) in plasma were detected and the pathological morphology of liver tissue was observed by HE staining.ResultsCompared with the model group, the plasma contents of TC, TG and LDL-C in high-dose Danshen Yin group were decreased (P<0.05), while the content of HDL-C was increased (P<0.05), and the plasma contents of TC and TG in low-dose Danshen Yin group were decreased (P<0.05). HL content in plasma of rats in high-dose and low-dose Danshen Yin groups was increased (P<0.05, P<0.01). The contents of LPL and MTP in liver tissues of rats in the high-dose and low-dose Danshen Yin groups were increased (P<0.05), and the content of HMG-coA reductase was decreased (P<0.05). Both Danshen Yin groups could significantly improve the pathological morphology of liver tissue in hyperlipidemia model rats, and the effect of high-dose Danshen Yin group was more obvious than that of low-dose Danshen Yin group.ConclusionDanshen Yin has significant lipid-lowering effect, and its mechanism may be related to the effect of Danshen Yin on lipid absorption, synthesis, transportation and metabolism.关键词：hyperlipemia;Danshen Yin;activating blood and resolving stasis;lipid metabolism;model rats;traditional Chinese herbal medicine research
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发布时间：2022-08-03 - 摘要：ObjectiveTo explore the effect of polysaccharides of bran-fried Atractylodis Rhizoma on rats of spleen deficiency model. MethodsSD male rats were randomly divided into blank group, model group, bran-fried Atractylodis Rhizoma group, polysaccharide low, medium and high dose groups, with 10 rats in each group. A rat spleen-deficiency syndrome model was established by the compound factor method of dietary disorders, excessive fatigue associated with diarrhea induced by bitter cold herbs. The rats were administered by gavage for 7 days to investigate the body weight, fecal water content and immune organ index. Somatostatin (SS), vasoactive intestinal peptide (VIP), gastrin (GAS), amylase (AMS), interleukin 6 (IL-6), tumor necrosis factor α (TNF-α), immunoglobulin (IgG), interleukin 4 (IL-4), globulin (GLB) and total protein (TP) were determined by enzyme linked immunosorbent assay (ELISA).ResultsCompared with the model group, polysaccharides could significantly increase the body weight and decrease the water content of feces in spleen deficiency rats(P<0.01), increase thymus index and spleen index in medium and high dose groups(P<0.01), increase GAS, AMS and IL-4, and decrease SS, VIP, IL-6, TNF-α, IgG, GLB and TP in all dose groups polysaccharides (P<0.01).ConclusionPolysaccharide of bran-fried Atractylodis Rhizoma has a good therapeutic effect on rats with spleen deficiency. It can be preliminarily determined that the polysaccharide is one of the effective ingredients of Atractylodis Rhizoma for strengthening the spleen.关键词：Atractylodis Rhizoma;bran-fried;spleen deficiency evidence;polysaccharide;pharmacophore;model rat;traditional Chinese herbal medicine research
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发布时间：2022-08-03 - 摘要：ObjectiveTo explore the mechanism of Jianpi Liqi Decoction in the treatment of functional dyspepsia (FD) by inhibiting degranulation of duodenal mast cells (MC), improving the expression of duodenal tight junction proteins (TJs) and restoring intestinal barrier function. MethodsTwenty-four 6-week-old SPF male SD rats were randomly divided into control group, model group, traditional Chinese medicine treatment group and CRH antagonist group, 6 rats in each grpup. Except for the control group, the FD model was established by tail clamping stress in other groups. After the establishment of the model, the control group and the model group were given pure water gavage, the traditional Chinese medicine treatment group given Jianpi Liqi Decoction gavage and the CRH antagonist group injected with antagonist intraperitoneally. After the intervention, the duodenum was taken and the expressions of corticotropin releasing hormone (CRH) major receptor 1 (CRHR1), MC marker protein trypsin (Tryptase), protease activated receptor 2 (PAR-2), myosin light chain kinase (MLCK), and TJs (JAM-A, ZO-1, claudin-1) in the duodenum were determined by Western blot.ResultsCompared with the control group, the expressions of CRHR1, Tryptase, PAR-2, MLCK in the duodenum of the model group were significant increased (P<0.05), while the expressions of TJs (JAM-A, ZO-1, claudin-1) were down-regulated (P<0.05). Compared with the model group, the expressions of CRHR1, Tryptase, PAR-2 and MLCK in the traditional Chinese medicine group and CRH antagonist group were down-regulated, while the expression of TJs (JAM-A, ZO-1, claudin-1) was significantly increased.ConclusionCRH-mediated activation of MC, release of inflammatory mediators and down-regulation of local TJs expression in the duodenum resulting in barrier damage may be one of the pathogenesis of FD, and Jianpi Liqi Decoction may inhibit the injury pathway, restore the function of local duodenal barrier and play a therapeutic role in FD.关键词：functional dyspepsia;Jianpi Liqi Decoction;duodenum;CRH;mast cells;tight junction proteins;intestinal barrier;traditional Chinese herbal medicine research
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发布时间：2022-08-03 - 摘要：The study of traditional Chinese medicine (TCM) terminology is a fundamental work of research in various disciplines of TCM. This paper reviews research on the various steps of TCM terminology research (data selection, data pre-processing, data analysis, and expert review) in recent years and concludes that the core problems of such research are mainly difficulties in updating standards, inconsistent standards, and obsolete research methods. Meanwhile, in the study of TCM formula-syndrome terminology, this paper proposes a new method for quantitative comparative study of terms in the form of formula clusters through machine learning modeling.关键词：TCM terminology;TCM standardization;TCM informatization;ontology;data mining;machine learning;review
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发布时间：2022-08-03
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