最新刊期
期 1 ， 2021
- 摘要：The syndrome differentiation methods of exogenous febrile diseases include six meridians syndrome differentiation, Wei-Qi-Ying-Xue syndrome differentiation and triple energizers syndrome differentiation. The syndrome differentiation methods of endogenous miscellaneous diseases include syndrome differentiation based on zang-fu organs and meridians, and syndrome differentiation based on qi, blood and body fluids. There are differences between syndrome differentiation methods of exogenous febrile diseases and those of endogenous miscellaneous diseases. Exogenous febrile diseases tend to formulate a treatment plan according to individual conditions, while endogenous miscellaneous diseases aim at universally applicable methods. As more complicated clinical situation is faced by modern TCM physicians nowadays, attention should be paid to seeking common ground while reserving differences in various syndrome differentiation methods to summarize simpler and more universally applicable methods.关键词：exogenous febrile disease;endogenous miscellaneous diseases;syndrome differentiation and treatment
- 8
- |
- 217
- |
- 0
发布时间：2022-08-02 - 摘要：ObjectiveTo systematically survey the key target and mechanism of Huangqi (Astragali Radix) -Chuanxiong (Chuanxiong Rhizoma) (QX) in the treatment of diabetic peripheral neuropathy(DPN).MethodsThe main active components and targets of QX were researched through Traditional Chinese Medicine System Pharmacology Datebase (TCMSP) ; And the relevant disease targets of DPN were researched through GeneCards Database. The common targets of QX for DPN were gotten by Venn diagrams drawn through R language. The traditional Chinese medicine-ingredient-disease-target regulation network was constructed by Cytoscape 3.7.1, and a PPI network established through String data platform. Finally, the Bioconductor platform and R language were used for GO enrichment analysis and KEGG pathway analysis.ResultsTotally 19 active components of QX including quercetin, kaempferol, folacin and sitosterol played an important role in the treatment of DPN; 69 key targets such as PTGS2 and NOS2 played a therapeutic role; 93 items such as cytokine activity and cytokine receptor binding influenced biological process in the treatment of DPN; 143 pathways including AGE-RAGE signaling pathway and IL-17 pathway played a key point in the treatment of DPN.ConclusionThe therapeutic effect of QX on DPN reflects the characteristics of multi-components, multi-targets and multi-pathways of traditional Chinese medicine, suggesting that its mechanism may be realized through multi-components, multi-targets and multi-pathways, which provides ideas and basis for further exploring the treatment and mechanism of QX in the treatment of DPN.关键词：Astragali Radix;Chuanxiong Rhizoma;diabetic peripheral neuropathy;network pharmacology
- 9
- |
- 764
- |
- 0
发布时间：2022-08-02 - 摘要：ObjectiveTo systematically evaluate the clinical effect of acupuncture and moxibustion on improving depressive state and activities of daily living (ADL) of patients with post-stroke depression.MethodsClinical randomized controlled trials (RCTs) of acupuncture and moxibustion treatment for post-stroke depression published from August 27, 2009 to August 27, 2019 were collected by searching China National Knowledge Network (CNKI), VIP, Wanfang Data, Sinomed (CBM), PubMed, Cochrane and other databases. Cochrane risk bias assessment tool was used to evaluate the quality of literature, and RevMan 5.3 software was used for meta-analysis.ResultsA total of 14 RCTs were included involving 1,120 cases. Meta-analysis results showed that compared with antidepressants, acupuncture and moxibustion treatment had better antidepressant effects [RR=1.15, 95% CI(1.09, 1.21), P<0.000 01], which could better improve the depressive state of patients [SMD=-0. 58, 95% CI(-0.74,-0.43), P<0.000 01], and improve the activities of daily living [SMD=0.71, 95% CI(0.40, 1.02), P<0.000 01].ConclusionsAcupuncture and moxibustion treatment is superior to antidepressants in improving the depressive state and activities of daily living of patients with post-stroke depression. Most of the documents included in the analysis have methodological defects and the level of evidence is not high enough, so the conclusion needs further verification.关键词：post-stroke depression;acupuncture and moxibustion;Meta-analysis;Hamilton Depression Scale
- 12
- |
- 784
- |
- 0
发布时间：2022-08-02 - 摘要：Professor Zhu Lingyun’s clinical experience in treating "damp constipation" was introduced, which highlighted that the main pathogenesis of dampness is deficiency of spleen and stomach resulting in retention of damp turbidity and stagnation of qi. Corresponding treatment methods of fortifying the spleen and replenishing qi, dispelling dampness and resolving turbidity, moving qi and removing stagnation were proposed, and a specialized prescription—Hezhong Huazhuo Daozhi Decoction for the treatment of damp constipation was designed, which showed satisfactory clinical effects. One proven case was exemplified.关键词：constipation;damp constipation;fortifying the spleen and replenishing qi;dispelling dampness and resolving turbidity;moving qi and removing stagnation;famous doctor’s experience;Zhu Lingyun
- 6
- |
- 307
- |
- 0
发布时间：2022-08-02 - 摘要：To introduce Professor ZHU Shijie’s experiences in treating cough after lung cancer operation. Professor Zhu believes that cough after lung cancer operation is different from common cough, and traditional cough-relieving medicine has little effect on it. The treatment should be based on the etiology and pathogenesis of the disease, combined with the deficiency and excess of the syndrome and the severity of the disease. The pathogenesis of cough after lung cancer operation is deficiency in the root aspect and excess in the branch aspect, with deficiency of qi and yin as the root, blood stasis and toxin blocking collaterals as the branch, and the dysfunction of the lung in dispersion and descent is the root cause of postoperative cough of lung cancer operation. The clinical treatment is mainly based on the method of simultaneous application of purging and nourishing Chinese medicine, focusing on regulating qi activity and regulating the function of the spleen and stomach. Professor ZHU Shijie often uses a large amount of Haifushi (Pumex) as the monarch drug, and medication pairs such as Haifushi (Pumex) and Xuanfuhua(Flos Inulae), Niuxi(Radix Achyranthis Bidentatae) and Jugeng(Radix Platycodi), Taoren(Semen Persicae) and Lugen (Rhizoma Phragmitis)and so on. One proven case is presented.关键词：cough after lung cancer operation;cough;therapy of traditional Chinese medicine;clinical experience;Zhu Shijie
- 14
- |
- 720
- |
- 0
发布时间：2022-08-02 - 摘要：Based on redefining the term "Ji" and "Shengji" in chronic wound, it was divided "Ji" in the treatment of chronic wound into visible Ji and microcosmic Ji. Combined with clinical practice, it explained the different "Shengji" processes of chronic wound and the usages of TCM principles and prescriptions, so as to explore new ideas of treating chronic wound in TCM.关键词：chronic wound;visible Ji;microcosmic Ji;Shengji
- 9
- |
- 143
- |
- 0
发布时间：2022-08-02 - 摘要：Analyzing the similarity of pathogenesis between chronic prostatitis and ulcers, it is believed that Olibanum and Myrrha can improve the pain and dysuria symptoms with chronic prostatitis. Meanwhile, combined with pharmacological research, the anti-inflammatory and analgesic mechanisms of Olibanum and Myrrha are analyzed, and a case is presented.关键词：chronic prostatitis;ulcers;Olibanum;Myrrha;anti-inflammatory and analgestic mechanism;activating blood and resolving stasis
- 10
- |
- 642
- |
- 0
发布时间：2022-08-02 - 摘要：Gegen (Puerariae lobatae radix) can dispel pathogenic factors from muscles to relieve fever, promote fluid production to let out skin eruption, and rise clear yang to stop diarrhea. It is generally used to treat exogenous diseases which have the tendency of letting out skin eruption and diarrhea caused by the failure of clear yang to ascend. Based on the analysis of the corresponding clauses in Treatise on Exogenous Febrile Diseases and Miscellaneous Diseases, this paper analyzes the compatibility significance of Gegen in prescriptions taking pathogenesis as the starting point. It is considered that the main purpose of Zhang Zhongjing’s application of Gegen in the classical prescriptions is to elevate fluid.关键词：Puerariae lobatae radix;elevate fluid;Treatise on Exogenous Febrile Diseases and Miscellaneous Diseases;Zhang Zhongjing
- 12
- |
- 436
- |
- 0
发布时间：2022-08-02 - 摘要：The clinical significance of meridian sinew theory in spastic hemiplegia after stroke was discussed, following aspects such as interpretation, physiological function, pathological manifestations of meridian sinew, the relationship among the meridian sinew, defensive qi and brain, the relationship between spastic hemiplegia after stroke and meridian sinew disease, the rehabilitative principles and methods of spastic hemiplegia after stroke guided by the meridian sinew theory.关键词：meridian sinew theory;spastic hemiplegia after stroke;TCM rehabilitation;Bobath therapy
- 12
- |
- 747
- |
- 0
发布时间：2022-08-02 - 摘要：ObjectiveTo observe the clinical effect of Shiyan Prescription on mild and moderate ulcerative colitis (UC) of large intestine damp-heat syndrome.MethodsSixty patients with ulcerative colitis of large intestine damp-heat syndrome were randomly divided into treatment group and control group, with 30 cases in each group. The treatment group was administered Shiyan Prescription orally, while the control group was administered mesalazine enteric coated tablets orally. The course of treatment in both groups was 3 months. The clinical efficacy was observed, and the quantitative score of main symptoms, modified Baron score and the level changes of serum cytokines interleukin-1β (IL-1β) and interleukin-10 (IL-10) levels were detected and compared before and after treatment.Results①The total effective rates of the treatment group and the control group were 93.33% and 86.67% respectively. The clinical efficacy of the treatment group was significantly better than that of the control group (P<0.05). ②The quantitative scores of main symptoms in the two groups both decreased after treatment, and the difference before and after treatment was statistically significant (P<0.05). The treatment group showed more significant difference of main symptoms quantitative scores than that of the control group (P<0.05). ③The modified Baron score in the two groups both decreased after treatment(P<0.05). The treatment group showed more significant difference of modified Baron score than that of the control group (P<0.05). ④The expression level of IL-1β decreased significantly and the expression level of IL-10 increased significantly in both groups after treatment (P<0.05). The treatment group showed lower expression level of IL-1β and higher expression level of IL-10 compared with the condition in the control group after treatment (P<0.05).ConclusionCompared with mesalazine, Shiyan Prescription can better improve the main clinical symptoms and colonic mucosal lesions, reduce the level of serum IL-1β and increase the level of serum IL-10 in patients with ulcerative colitis.关键词：ulcerative colitis;Shiyan Prescription;mesalazine;large intestine damp-heat syndrome;TCM anti-inflammation;colonic mucosal lesion
- 18
- |
- 254
- |
- 0
发布时间：2022-08-02 - 摘要：ObjectiveTo observe the clinical efficacy of acupuncture based on syndrome differentiation combined with conventional western medicine in the treatment of chronic heart failure (CHF) .MethodsSeventy-two patients with CHF (heart function grade Ⅱ) were included and randomly divided into the treatment group and the control group, 36 cases in each group.The patients in the treatment group were treated with basic western medicine combined with acupuncture based on syndrome differentiation, and the patients in the control group were treated with basic western medicine combined with placebo acupuncture.The course of treatment in both groups was 1 month.The clinical efficacy of the two groups was evaluated; follow-up for 2 months after treatment, the levels of left ventricular ejection fraction (LVEF) and N-terminal B-type natriuretic peptide (NT-proBNP) were detected and compared before and after treatment and at follow-up for 2 months.Results①During the trial, one patient in the treatment group withdrew, and one patient dropped off and one patient was removed in the control group.Finally, 35 patients in the treatment group and 34 patients in the control group were included in the statistical analysis.②After treatment, the total clinical effective rates of the treatment group and the control group were 85.7% and 61.8% respectively, and the curative effect of the treatment group was better than that of the control group (P<0.05) .③After treatment and at follow-up, the level of LVEF in both groups was significantly increased (P<0.05) and the level of NT-proBNP was significantly decreased (P<0.05) compared with those before treatment, and after treatment, the level of LVEF in the treatment group was higher than that in the control group (P<0.05) .At follow-up, the level of LVEF was decreased (P<0.05) and the level of NT-proBNP was increased (P<0.05) in both groups compared with those after treatment, with no statistical differences between the two groups (P>0.05) .ConclusionAcupuncture based on syndrome differentiation combined with conventional western medicine can effectively improve the cardiac function indexes and relieve the clinical symptoms in treating patients with CHF, but its long-term effect needs to be further explored.关键词：chronic heart failure;acupuncture;syndrome elements;syndrome differentiation;randomized controlled trial
- 8
- |
- 197
- |
- 0
发布时间：2022-08-02 - 摘要：ObjectiveTo investigate the main compressive stimulation factors of cervical nerve root in patients with cervical spondylotic radiculopathy.MethodsNinety-eight patients with cervical spondylotic radiculopathy were enrolled as the cervical spondylotic radiculopathy group and fifty healthy subjects were enrolled as the healthy subject group. The scores of the symptoms and signs, and the incidences of cervical zygapophyseal joint subluxation and cervical disc herniation were compared between the two groups. The compressive stimulation factors of cervical nerve root in patients with cervical spondylotic radiculopathy were synthetically analyzed.Results①There were significantly statistical differences on the scores of subjective symptoms, physical examination and daily activity, and the total scores of symptoms and signs between the two groups (P<0.01) . ②The incidences of cervical zygapophyseal joint subluxation in the cervical spondylotic radiculopathy group and the healthy subject group were 82.65% and 10.00% respectively, with significantly statistical difference between the two groups (P<0.01) . ③The incidences of cervical disc herniation in the cervical spondylotic radiculopathy group and the healthy subject group were 41.84% and 4.00% respectively, with significantly statistical difference between the two groups (P<0.01) . ④The compressive stimulation factors of cervical nerve root in patients with cervical spondylotic radiculopathy were mainly cervical zygapophyseal joint subluxation and cervical disc herniation. The patients with only cervical zygapophyseal joint subluxation accounted to 43.88% (43/98) , the patients with cervical zygapophyseal joint subluxation and cervical disc herniation accounted to 22.45% (22/98) , and the patients with only cervical disc herniation accounted to 4.08% (4/98) .ConclusionThe key clinical pathogenesis of cervical spondylotic radiculopathy on the one hand is related to cervical disc herniation leading to the compressive stimulation of cervical nerve root, on the other hand is related to cervical zygapophyseal joint subluxation leading to the compressive stimulation of cervical nerve root, while the latter is often neglected in clinical practice and should be paid more attention by clinical workers of cervical spondylosis prevention and treatment.关键词：cervical spondylotic radiculopathy;cervical zygapophyseal joint subluxation;cervical disc herniation;etiology and pathogenesis
- 49
- |
- 942
- |
- 0
发布时间：2022-08-02 - 摘要：ObjectiveTo provide objective basis for TCM syndrome differentiation by analyzing the characteristics of tongue diagnosis image parameters in patients with high risk diabetic foot of different TCM syndromes.MethodsThe smart TSM-I tongue-and-face diagnostic machine was used to take photos of tongue images of patients with high risk diabetic foot in three common TCM syndromes (cold coagulation and stasis stagnation syndrome, heat toxin injuring yin syndrome and qi-blood dual deficiency syndrome). The image parameters of tongue body and tongue coating were identified and extracted by analysis software, and the characteristic parameters of different TCM syndromes were analyzed accordingly.Results①Image parameters of tongue body: compared with the condition in patients with qi-blood dual deficiency syndrome, the H value of the whole tongue body, the middle part and the tip of the tongue increased (P<0.05) and the B value of the tip of the tongue decreased (P<0.05) in patients with cold coagulation and blood stasis syndrome, and the R value, B value and V value of the tip of the tongue in patients with heat toxin injuring yin syndrome decreased (P<0.05); Compared with the condition in patients with heat toxin injuring yin syndrome, the H value of tongue root and middle part of tongue in patients with cold coagulation and blood stasis syndrome increased (P<0.05). ②Image parameters of tongue coating: compared with the condition in patients with qi-blood dual deficiency syndrome, the B value, H value of the overall color of tongue coating and H value of tongue root color in patients with cold coagulation and blood stasis syndrome increased (P<0.05), while the G value of tongue tip color in patients with heat toxin injuring yin syndrome decreased (P<0.05).ConclusionThere are some differences in tongue diagnosis image parameters of patients with high risk diabetic foot of different syndromes, which can reflect TCM pathogenesis of high risk diabetic foot of different syndromes and provide some objective basis for the holistic and visceral syndrome differentiation.关键词：high risk diabetic foot;diabetic foot;TCM syndromes;TCM diagnostics;tongue diagnosis;TCM syndrome objectification
- 33
- |
- 368
- |
- 0
发布时间：2022-08-02 - 摘要：ObjectiveTo observe the clinical effect of Yiqi Huayu Decoction on intracranial residual hematoma after burr hole drainage surgery of chronic subdural hematoma (CSDH).MethodsA total of 56 patients with chronic subdural hematoma were randomly divided into treatment group (n=33) and control group (n=23). Both groups conducted burr hole drainage surgery. After surgery, the treatment group was treated with Yiqi Huayu Decoction, while the control group was treated with atorvastatin tablets. The two groups were administered corresponding medicine continuously for at least 4 weeks until the residual hematoma was completely absorbed or the volume significantly reduced (V≤10 cm3).Results①During the follow-up period, there were 2 dropout cases, including 1 case in the treatment group and 1 case in the control group. ②The differences in the volume of residual hematoma were significant (P<0.05) when comparing the volume before operation and that at each time point after operation in both groups. The differences in the volume reduction rate of residual hematoma were significant statistically when comparing the reduction rate on day 7 after operation and that on day 14, day 30, day 60 and day 180 respectively after operation in both groups (P<0.05). The volume of residual hematoma in the treatment group was significantly smaller than that in the control group on day 60 and day 180 after operation (P<0.05), and the volume reduction rate of residual hematoma in the treatment group was significantly higher than that in the control group on day 30, day 60 and day 180 after operation (P<0.05). ③During the follow-up period, the recurrence rates of residual hematoma in the treatment group and the control group were 3.1% (1/32) and 13.6% (3/22), respectively, with no significant difference (P>0.05). ④Logistic regression analysis showed that the old age (>80 years old) and the smaller hematoma volume reduction rate after operation (<30%) were closely related to hematoma recurrence (P=0.008,P=0.01). ⑤The modified Rankin score of the two groups decreased significantly before and after operation (P<0.05). There was no significant difference in modified Rankin score between groups at each time point after operation (P>0.05). ⑥There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05).ConclusionCompared with atorvastatin tablets, Yiqi Huayu Decoction can better promote the absorption of residual hematoma after burr hole drainage surgery in patients with chronic subdural hematoma. Meanwhile, without severe adverse reactions, Yiqi Huayu Decoction can also improve the postoperative neurological function of patients.关键词：chronic subdural hematoma;the elderly;burr hole drainage surgery;traditional Chinese medicine therapy;intracranial residual hematoma;recurrence after operation;neurological function
- 29
- |
- 185
- |
- 0
发布时间：2022-08-02 - 摘要：ObjectiveTo explore the effect of Mingmu Jiedu Prescription (MJP) fumigation on herpes simplex keratitis(HSK)by means of heat and drug separation.MethodsNinety healthy New Zealand white rabbits were randomly divided into five groups: model group (n=18) , traditional Chinese medicine thermal fumigation group (n=18) , thermal fumigation group (n=18) , fumigant group (n=18) and normal group (n=18) .Except for the normal group, all the other groups were inoculated with HSV-1 virus to establish HSK mode by ocular surface scratching method. After modeling, the model group and normal group were not treated with drugs, while the traditional Chinese medicine thermal fumigation group was fumigated with MJP every day, the thermal fumigation group was fumigated with distilled water, and the fumigant group was treated with MJP fumigation liquid eye drops.The degree of keratopathy in each group was evaluated at 1 day before modeling and 1 day, 3 days and 7 days after modeling.On the 1st, 3rd and 7th days after treatment, 6 eyes in each group were randomly selected for detecting the expression of HSV-1 in corneal tissue by PCR method, the contents of IL-2 and IFN-γ in aqueous humor by ELISA method, and the protein expressions of CD4, CD8 in peripheral blood by Western blot method.ResultsOn the 3rd and 7th days after treatment, the corneal HSV-1 contents in the traditional Chinese medicine thermal fumigation group, the fumigant group and the thermal fumigation group were lower than those in the model group (P<0.05) .But there was no significant difference in the content of IFN-γ in aqueous humor among the three groups (P>0.05) .On the 7th day after treatment, there was interaction between traditional Chinese medicine thermal fumigation group and thermal fumigation group. On the 1st, 3rd and 7th days after treatment, the content of IL-2 in aqueous humor of the traditional Chinese medicine thermal fumigation group was significantly different from that of the model group, and there was significant difference between the fumigant group and the model group on the 1st and 7th days after treatment (P<0.05) .The expression of CD4 protein in peripheral blood in the traditional Chinese medicine thermal fumigation group was significantly higher than that in the model group after 3 and 7 days of treatment (P<0.05) .ConclusionMJP fumigation treatment can eliminate HSV-1 virus in HSK corneal tissue through thermal and drug effects, affect the level of local immune factor IL-2, and up-regulate the expression of CD4 in peripheral blood.关键词：herpes simplex keratitis(HSK-1);rabbits;heat and drug separation;Mingmu Jiedu Prescription;thermal effect;fumigation of traditional Chinese medicine
- 10
- |
- 112
- |
- 0
发布时间：2022-08-02 - 摘要：ObjectiveTo study whether MTH, the active fraction of Incavillea arguta (Royle) Royle, has anti-inflammatory, analgesic and choleretic effects and to observe whether its effect is better than that of the crude extract of Incavillea arguta.MethodsThe mice formaldehyde pain test and mice hot plate test were used to study the analgesic condition of MTH and the crude extract of Incavillea arguta (Royle) Royle, and the models of xylene-induced ear edema and the carrageenan-induced paw edema of mice were used to study the anti-inflammatory effect of MTH and the crude extract of Incavillea arguta (Royle) Royle, and finally the gallbladder weight test in the mice and the gallstone samples collected from clinical patient were carried out to study its choleretic and stone-dissolving effect.Results①The analgesic test: compared with the model group, at 30 min, in hot plate test, medium and high dose groups of MTH could enhance the rate of pain threshold efficiency in mice (P<0.05) ; and in mice formaldehyde pain test, medium and high dose of MTH could reduce the formaldehyde-induced pain score in the first phase and the second phase (P<0.05, P<0.01) , and the analgesic effects were better than that of the crude extract of Incavillea arguta (Royle) Royle. ②The anti-inflammatory test: compared with the control group, high, medium and low dose groups of MTH significantly inhibited xylene-induced ear edema in mice, and the inhibition rates were respectively 45.21%, 41.89%, 23.83% (P<0.01, P<0.01, P<0.05) , and the inhibition rates of the crude extract of Incavillea arguta (Royle) Royle was 16.64%, lower than that of the high and medium dose groups of MTH (P<0.05) . Both medium and high dose groups of MTH could inhibit toe swelling in mice (P<0.01, P<0.01).③The choleretic test: compared with distilled water group, high, medium and low dose groups of MTH and the crude extract of Incavillea arguta (Royle) Royle could reduce the gallbladder weight of mice, promote bile excretion (P<0.01) and choleretic effect of MTH was better than that of the crude extract of Incavillea arguta (Royle) Royle, and high, medium and low dose groups of MTH and the crude extract of Incavillea arguta (Royle) Royle could effectively dissolve cholecystolithiasis (P<0.01) .ConclusionMTH has obvious analgesic, anti-inflammatory and choleretic effects, and the effect is better than that of the crude extract of Incavillea arguta (Royle) Royle.关键词：Incavillea arguta (Royle) Royle;analgesic;anti-inflammatory;choleretic;mice
- 13
- |
- 291
- |
- 0
发布时间：2022-08-02 - 摘要：ObjectiveTo establish the quality control method for fresh LiLii Bulbus.MethodsQualitative identification of fresh LiLii Bulbus was established by thin layer chromatography (TLC) method, and the content of regaloside B was determined by high performance liquid chromatrgraphy (HPLC) method. Water, total ash, and water-soluble extractives were also determined according to the Chinese Pharmacopeia (2015 Version, Volume 4) .ResultsTLC was carried out by using silica gel G as the coating substance and petroleum ether-dichloromethane-ethyl acetate-methanol (7∶10∶7∶2) as developer. After exposing to sulfuric acid ethanol (10%) , the thin layer plates were examined under ultraviolet light at 365 nm. The fresh LiLii Bulbus sample showed the same color spots in the same position as the control, with clear spots and good repeatability. The HPLC was performed by Agilent C18 column (4.6 mm×250 mm,5 μm), with acetonitrile-0.1% phosphoric acid (17∶83) as mobile phase, detection wavelength 312 nm, column temperature 25 ℃, flow rate 1.0 mL/min and injection volume 20 μL. Under the condition, the linear range of regaloside B was 10.27-164.32 mg/L (R2=0.999 7), and the average recovery was 100.08% (RSD 2.31%). In 20 batches of samples, the content ranges of regaloside B, water, total ash and water-soluble extractives were 0.62-4.71 mg/g, 7.53%-4.22%, 2.63%-4.88% and 23.07%-43.01%, respectively.ConclusionThe established quality control method of fresh LiLii Bulbus is accurate, stable and repeatable, and can be used for the quality control of fresh LiLii Bulbus.关键词：fresh LiLii Bulbus;regaloside B;quality standard;thin layer chromatography (TLC);high performance liquid chromatrgraphy (HPLC)
- 7
- |
- 527
- |
- 0
发布时间：2022-08-02 - 摘要：ObjectiveTo observe the effect of Shidao Tongjie Decoction on micro angiogenesis of human esophageal cancer xenografts in nude mice. MethodsThe xenograft model of human esophageal carcinoma was established by subcutaneous inoculation of human esophageal carcinoma cell line TE-1. Forty tumor bearing mice were randomly divided into 4 groups: model group, Chinese medicine group, cisplatin group and Chinese medicine + cisplatin group. The mice in each group were intervened with 0.9%NaCl, Shidao Tongjie Decoction (18 g·kg-1·d-1, ig, 28 d) , cisplatin (1 mg·kg-1·d-1, ip, d1, d3, d5) , Shidao Tongjie Decoction (18 g·kg-1·d-1, ig, 28 d) + cisplatin (1 mg·kg-1·d-1, ip, d1, d3, d5) , respectively. The growth of transplanted tumor was observed. The expression of CD34 was detected by immunohistochemistry, and microvas cular density (MVD) was calculated according to the expression of CD34. The expressions of vascular endothelial growth factor A (VEGFA) protein was detected by immunohistochemistry.The expressions of VEGFA, vascular endothelial growth factor receptor 2 (VEGFR2) and p-VEGFR2 protein were detected by Western blot.ResultsCompared with the model group, the volume and weight of transplanted tumor in treatment groups were significantly reduced (P<0.01) , and the effect of Chinese medicine plus cisplatin was the best (P<0.05) . Compared with the model group, the expressions of MVD, VEGFA and p-VEGFR2 in the tumor tissues of the Chinese medicine group, cisplatin group and the Chinese medicine + cisplatin group decreased significantly (P<0.05) , and the effects of the Chinese medicine + cisplatin group on the expression of MVD, VEGFA and p-VEGFR2 were more significant (P<0.05) .ConclusionShidao Tongjie Decoction has the effect of anti-angiogenesis of esophageal cancer, which is related to the inhibition of VEGFA/VEGFR2 pathway.关键词：Shidao Tongjie Decoction;esophageal cancer;mice;tumor angiogenesis;VEGFA/VEGFR2 pathway
- 13
- |
- 210
- |
- 0
发布时间：2022-08-02 - 摘要：ObjectiveTo study the effects of Aigui Gel Ointment on improving sexual dysfunction in male mice.MethodsQualified ICR male mice were randomly divided into the normal control group (n=12) and the model group (n=60) . The kidney-yang deficiency mice model due to "excessive fatigue and intercourse" was built in the model group. After successful modeling, the mice in the model group was randomly divided into 5 groups with 12 mice in each group, including model control group, positive control group and low, medium and high dose Aigui Gel Ointment groups. The mice in each experimental group were shaved off their backs, and the blank drugs were applied in the back depilation area of the mice in the normal control group and in the model control group as the follow-up control group. The mice in the positive control group was applied with Yishen Healthcare Paste (0.274 g/g) , and the mice in the low, medium and high dose groups were applied with Aigui Gel Ointment (0.172 g/kg, 0.343 g/g, 0.686 g/g) . The drugs were applied 12 hours, once a day for 28 days. The indices including body mass, anal temperature, cold tolerance, reproductive organ index, and serum levels of follicle stimulating hormone (FSH) , luteinizing hormone (LH) , testosterone (T) and estradiol (E2) were measured.ResultsCompared with the model control group, Aigui Gel Ointment could increase the body mass, anal temperature, cold tolerance and testicular organ index, increase the content of serum T and decrease the contents of FSH, LH and E2 in serum (P<0.05, P<0.05) .ConclusionAigui Gel Ointment can significantly improve the sexual function of mice with kidney-yang deficiency due to excessive fatigue and intercourse.关键词：Aigui Gel Ointment;kidney yang deficiency;sexual dysfunction;mice
- 15
- |
- 267
- |
- 0
发布时间：2022-08-02 - 摘要：From high-frequency drugs analysis, high-frequency drug pairs analysis and high-frequency drug groups analysis as the entry point, this paper reviewed the research progress on the regularity of prescription of traditional Chinese medicine in the treatment of tinnitus.High-frequency drugs analysis included high-frequency drugs, high-frequency syndrome drugs and high-frequency drug properties;There were two kinds of high-frequency drug pairs: "brotherly" compatibility mode (i.e., same drug properties) and "conjugated" compatibility mode (i.e., different drug properties); High-frequency drug groups analyzed the common types and cluster drug groups of tinnitus from deficiency syndrome, excess syndrome, deficiency and excess syndrome.关键词：tinnitus;regularity of prescription;Chinese medicine;review
- 8
- |
- 941
- |
- 0
发布时间：2022-08-02 - 摘要：The progress in surgical application of transcutaneous electrical acupoint stimulation (TEAS) therapy was reviewed in this article. TEAS can not only assist the intraoperative and postoperative analgesia, reduce the dose of anesthetic drugs, reduce immunosuppression and stress response of operation, maintain hemodynamic stability, and protect organs such as heart, brain, lung, liver and kidney, but also can reduce the postoperative adverse reactions of patients to improve their rehabilitation quality. TEAS can be widely used, either during the operations or after operations, in orthopedics, brain surgery, thyroid surgery, breast surgery and cardiothoracic surgery, etc. as it has the advantages of infection-free, non-invasiveness, good patient tolerance, and repeatability. Perhaps it will become a trend in the clinic to replace traditional electroacupuncture.关键词：transcutaneous electrical acupoint stimulation;acupuncture;anesthesia;analgesia;surgical operation;clinical application;review
- 15
- |
- 827
- |
- 0
发布时间：2022-08-02
- Technical support is provided by Beijing Founder electronics co., LTD 沪ICP备13044091号
沪公网安备 31011502015228号 - It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
- Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.
- Total Visits：70575 Visits Today：56
0