最新刊期
期 9 ， 2020
- 摘要：To briefly summarize the clinical adverse reactions and reasonable application of Jinhuang preparation based on the theory of Gu-Wei-Hu-Chang(hoop protection field). Jinhuang preparation is one of the external preparations of TCM with good curative effect, which has the effect of clearing away heat to remove toxin and cooling blood to subside swelling. The Gu-Wei (hoop) method can mobilize and gather healthy qi to form a protective field to achieve the barrier function to prevent pathogenic factors from spreading and further accumulating. It is widely used as Gu-Wei medicine in the early stage of abscess and sores, which can achieve the function of limit sores and make the abscess subside.However, in the course of using, the adverse reactions of Jinhuang preparation caused by the difference of dosage forms and patients’ constitution should also be paid attention to.Therefore, when using Jinhuang preparation,it should be used flexibly according to the actual situation to avoid the occurrence of related adverse events.关键词：Jinhuang preparation;clinical adverse reactions;Gu-Wei;Hu-Chang;Reasonable application
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发布时间：2022-08-31 - 摘要：Objective:To explore the tongue color parameters of Framingham cardiovascular risk groups and patients with coronary heart disease.MethodsA total of 240 patients with coronary heart disease were recruited and 286 people for physical examination were collected.According to the Framingham risk score(FRS),physical examination people were divided into 10-year low-risk group(n=216),medium-risk group(n=55)and high-risk group(n=15).TCM tongue diagnosis instrument was used to collect tongue images,and the tongue images were analyzed based on RGB and HSV color space. Results:The tongue color G,B,S values of the low-risk group were statistically different from those of the coronary heart disease group(P<0.05), The G,B values of tongue color in the coronary heart disease group were higher than those in the low-risk group(P<0.05),and the S value was lower than that in the low-risk group(P<0.05)；The tongue color G,S values in the middle-risk group were statistically different from those in the low-risk group(P<0.05).The tongue color G value of the middle-risk group was higher than that of the low-risk group(P<0.05),and the S value was lower than that of the low-risk group(P<0.05).The tongue-tip color G,B,S values of the low-risk group were statistically different from those of the coronary heart disease group(P<0.05)；The tongue-tip color G,B values of the coronary heart disease group were higher than those of the low-risk group(P<0.05),the tongue-tip color S value in coronary heart disease group was lower than that in low-risk group(P<0.05)；The tongue-tip color R,V values in middle-risk group were lower than that in low-risk group(P<0.05)；The tongue-tip color R value in coronary heart disease group was higher than that in middle-risk group(P<0.05). Conclusion:There are differences in tongue color parameters in FRS 10-year coronary heart disease low-risk group,middle-risk group,high-risk group and coronary heart disease patients.Tongue diagnosis with a certain reference for predicting the risk of coronary heart disease.关键词：coronary heart disease;Framingham risk score;tongue image;tongue diagnosis;objectification
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发布时间：2022-08-31 - 摘要：Objective:To analyzes the rules of Professor Tang Hanjun’s internal and external treatment methods for complex sinuses, and summarize his academic thoughts through data mining methods. MethodsThe medical records of Professor Tang Hanjun’s treatment of complex sinuses were sorted out, and TCM clinical diagnosis and treatment information database of complex sinuses was established. Data mining technologies such as frequency analysis and correlation analysis were used to analyze the general characteristics of patients, the compatibility rules of formulas in internal treatment and the use of external treatment methods. Results:①The study included 265 medical records. Among 265 patients, there were more males than females, with a median age of 55 years old and a median course of disease of 210 days. A total of 136 cases (51.32%) were complicated with diabetes, viral hepatitis B and other diseases. The most commonly affected area was chest wall (34.7%), and surgery (64.53%) and infection (23.40%) were common causes. According to syndrome differentiation and classification of traditional Chinese medicine (TCM), incompletely removed residual toxin syndrome was the most common syndrome(78.87%), followed by dual deficiency of qi and blood syndrome (20.38%), but vital qi deficiency and lingering toxin syndrome was relatively rare (0.75%). ②A total of 229 patients received TCM treatment orally, involving 229 kinds of medicinals, with a total use frequency of 4,234 times. A total of 13 kinds of medicinals were used more than 100 times, mainly focusing on medicinals for invigorating qi and spleen, invigorating spleen and activating blood circulation, and invigorating qi and removing dampness. ③The results of correlation analysis showed that the most commonly used pair compatibility combinations were mainly medicinals for invigorating qi and spleen, invigorating spleen and activating blood circulation, and invigorating qi and removing dampness. The compatibility combinations of three medicinals mainly included combinations of medicinals for invigorating spleen and nourishing blood, invigorating spleen and activating blood circulation, invigorating qi and spleen, invigorating spleen and removing dampness, invigorating spleen and expelling toxin. The compatibility combinations of four medicinals were mainly the combinations of raw Huangqi (Radix Astragali), Baizhu (Rhizoma Atractylodis Macrocephalae), Fulin (Poria Cocos) and medicinals for removing dampness, activating blood circulation and expelling toxin by supporting vital qi. The compatibility combinations of five medicinals was the combination of medicinals for invigorating qi, invigorating spleen, strengthening vital qi, cooling blood, activating blood circulation and eliminating stagnation composed of raw Huangqi (Radix Astragali), Baizhu (Rhizoma Atractylodis Macrocephalae), Fulin (Poria Cocos), Chishao (Radix Paeoniae Rubra) and Danshen (Radix Salviae Miltiorrhizae). ④Commonly used external treatment methods included dusting powdered drugs, plastering and application, flushing and infusing therapy, corrosive drug stick, and drainage through gauze, etc. Conclusion:Professor Tang Hanjun attaches great importance to strengthening vital qi in the treatment of complex sinuses, especially the supplementation of spleen and stomach. He applies the methods of tonifying, dredging and regulating qi, blood, channels and collaterals while expelling and removing toxins, which embody his academic thought of treating complex sinuses by strengthening vital qi. Various external treatment methods are flexibly used with the internal treatment methods to achieve satisfactory therapeutic effects.关键词：complex sinus;fistula;veteran TCM doctor’s experience;data mining;Tang Hanjun
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发布时间：2022-08-31 - 摘要：Sini powder is mainly used to treat Shaoyang disease. The powder has efficacy of reconciling Shaoyang to clear away heat,promoting qi flow to relieve depression, and replenishing qi to nourish blood. Based on five proven cases, this paper introduces the clinical experience of applying Sini powder combined with other prescriptions.关键词：Treatise on Febrile Diseases;classical prescription;Sini Powder;combined prescription
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发布时间：2022-08-31 - 摘要：Vascular dementia (VD) has complicated etiology and pathogenesis,but in general,it is mainly due to kidney deficiency and lack of marrow. The kidney is the congenital foundation. It contains the essence and the marrow to fill the brain,and the brain is the sea of marrow,so the kidney and the brain are closely related. Therefore,the treatment of VD should enrich the kidney and fill the essence. The theory of kidney-brain correlation is rooted in the correlation between their yin and yang,meridians,essence and mind. Analyzing the physiology and pathology of the kidney and brain from the perspective of traditional Chinese medicine and modern medicine, not only provides an accurate diagnosis and treatment idea for treating VD from the kidney,but also provides a certain scientific basis for the practical application of kidney-brain related theories.关键词：kidney-brain correlation;vascular dementia;treatment from Kidney
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发布时间：2022-08-31 - 摘要：Objective:To evaluate the effect of integrated traditional Chinese and western medicine treatment on the overall survival of patients with advanced pancreatic adenocarcinoma. MethodsBy adopting non-randomized simultaneous case-control method, patients with advanced pancreatic adenocarcinoma were divided into traditional Chinese medicine (TCM) group and non-TCM group according to whether they received TCM or not; Patients with advanced pancreatic adenocarcinoma were divided into integrated treatment group and western medicine treatment group according to whether they received standard anti-tumor western medicine treatment (chemotherapy and/or radiotherapy). Taking the overall survival (OS) as the main efficacy evaluation index, Cox multivariate regression analysis was used to analyze the factors influencing the survival time of advanced pancreatic adenocarcinoma, and Kaplan-Meier method was used to estimate the median survival time, and the impact of integrated traditional Chinese and western medicine treatment on the survival time of patients with advanced pancreatic adenocarcinoma was evaluated. Results:①A total of 305 patients with advanced pancreatic adenocarcinoma were included, with 157 cases in the TCM group and 148 cases in the non-TCM group; 245 patients were treated with standard anti-tumor western medicine treatment (chemotherapy and/or radiotherapy), 127 cases in the integrated treatment group and 118 cases in the western medicine treatment group. ②The median OS of the TCM group was 14.9 months, significantly longer than that of the non-TCM group, which was 9.6 months (P<0.001, HR=0.471,95% CI:0.361~0.613); The median OS was 14.1 months in the integrated treatment group, which was significantly longer than 9.7 months in the western medicine treatment group (P<0.001, HR=0.491,95% CI:0.367~0.658). ③The 1-, 2-, 3-, and 5-year survival rates were 41%, 23%, 16% and 11% in the TCM group while those of non-TCM group were 18%, 11%, 6% and 3% respectively, with statistically significant difference (P<0.001); The 1-, 2-, 3-, and 5-year survival rates in the integrated treatment group were 37%, 19%, 12% and 8% respectively, while those in the western medicine treatment group were 16%, 10%, 5% and 1% respectively, with statistically significant difference (P<0.001). ④Multivariate analysis showed that age (P=0.003), KPS score (P<0.001), surgery (p<0.001), chemotherapy (P<0.01) and TCM (P<0.001) were independent prognostic factors affecting the survival of patients with advanced pancreatic adenocarcinoma, and age and chemotherapy were non-protective independent prognostic factors. ⑤The incidence of leukopenia, neutropenia, thrombocytopenia, nausea and vomiting in the integrated treatment group was lower than that in the western medicine treatment group (P<0.05). Meanwhile, the incidence of grade Ⅲ~Ⅳ leukopenia and thrombocytopenia in the integrated treatment group was lower than that in the western medicine treatment group (P<0.05). Conclusion:Traditional Chinese herbal medicine treatment is an independent prognostic factor affecting the survival of patients with advanced pancreatic adenocarcinoma; integrated traditional Chinese and western medicine treatment can prolong the overall survival of patients with advanced pancreatic adenocarcinoma, and reduce the incidence of leukopenia, thrombocytopenia, nausea and vomiting after chemotherapy.关键词：pancreatic adenocarcinoma;advanced;traditional Chinese medicine treatment;overall survival
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发布时间：2022-08-31 - 摘要：Objective:To observe the effect of Qingxia Huayu decoction combined with conventional western medicine therapy on gastrointestinal function and prognosis scoring system in patients with moderate and severe acute pancreatitis. MethodsSixty-six patients with moderate and severe acute pancreatitis were randomly divided into treatment group and control group, 33 cases in each group. The control group was treated with conventional western medicine, and the treatment group was treated with Qingxia Huayu decoction besides treatment measures of the control group. After 7 days of treatment, the clinical efficacy and gastrointestinal function recovery of the two groups were observed, and the changes of TCM syndrome score, acute gastrointestinal injury (AGI) score, bedside index for severity in acute pancreatitis (BISAP) score, acute physiological and chronic health evaluation II (APACHE II) score and modified computed tomography severity index (MCTSI) score were compared. Results:①In the course of the trial, the treatment group and the control group lost 3 cases respectively, and 60 cases finally completed the trail with 30 cases in the treatment group and 30 cases in the control group. ②The total effective rates of the treatment group and the control group were 96.7% and 83.3% respectively, and the clinical efficacy of the treatment group was better than that of the control group (P＜0.05). ③TCM syndrome scores in both groups decreased when compared before and after treatment (P＜0.05). After treatment, the difference in TCM syndrome scores between two groups was statistically significant (P＜0.05). ④With the prolongation of treatment time, AGI scores of the two groups gradually decreased (P＜0.05). The AGI score of the treatment group was lower than that of the control group on the 3rd, 7th and 14th day of treatment (P＜0.05). ⑤The time of enteral nutrition reaching the standard and the elapsed time of abdominal pain, abdominal distension, nausea, vomiting and constipation in the treatment group was shorter than that in the control group (P＜0.05). ⑥The scores of BISAP, APACHE Ⅱ and MCTSI decreased in the two groups after treatment and the differences compared before and after treatment were statistically significant (P＜0.05); After treatment, BISAP score, APACHE Ⅱ score and MCTSI score in the treatment group were lower than those in the control group (P ＜0.05). Conclusion:Compared with conventional western medicine therapy alone, the combined use of Qingxia Huayu decoction with western medicine therapy is more effective in treating moderate and severe acute pancreatitis, which can better promote the recovery of gastrointestinal function and further improve the clinical symptoms and prognosis of patients.关键词：Acute Pancreatitis;severe acute pancreatitis;Qingxia Huayu decotion;acute gastrointestinal injury;gastrointestinal function;prognosis
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发布时间：2022-08-31 - 摘要：Objective:To scientifically evaluate TCM efficacy evaluation scale for qi deficiency syndrome, and lay a foundation for the clinical application and promotion of the scale. MethodsThe feasibility (acceptance rate, completion rate, filling time and ceiling and floor effects), reliability (internal consistency reliability and test-retest reliability), validity (content validity, structure validity and criterion validity) and responsiveness of the TCM efficacy evaluation scale for Qi deficiency syndrome were evaluated by epidemiological investigation. Results:①The acceptance rate of the scale was 95.83%, the completion rate was 100%, and the average completion time was 2.2 minutes. No ceiling and floor effects were found in all items. ②The test-retest reliability of the total table was 0.954, and the retest reliability of 10 items was greater than 0.7; The Cronbach coefficient of the general table, fatigue dimension, shortness of breath dimension and mental fatigue dimension was 0.827,0.674,0.768 and 0.614 respectively. The correlation coefficient between the dimension score of each item and the total score of the scale was greater than 0.4 except item 2. ③Three factors were screened out through factor analysis, with a cumulative contribution rate of 62.358%. Among them, the factor analysis of item 8 was different from the assumption framework, but the original scale structure was still retained after expert group discussion. The total score of the scale, fatigue dimension score, shortness of breath dimension score and mental fatigue dimension score showed negative correlations with the hemoglobin level. ④The scale score of Qi deficiency syndrome group was higher than that of healthy group, and the difference was statistically significant (P<0.01). Conclusion:TCM efficacy evaluation scale for qi deficiency syndrome has good feasibility, reliability, validity and responsiveness, and can be used as a quantifiable measurement tool for clinical efficacy evaluation of patients with qi deficiency syndrome.关键词：qi deficiency syndrome;scale;feasibility;reliability;validity;responsiveness
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发布时间：2022-08-31 - 摘要：Objective:To observe the effect of Tongsaimai tablets combined with conventional therapy on inflammatory factors and hemorheology in patients with diabetic foot. MethodsEighty patients with diabetic foot were randomly divided into treatment group and control group, with 40 cases in each group. The control group was given conventional therapy (to control blood sugar, improve microcirculation and fight infection, etc.), while the treatment group was given Tongsaimai tablets besides the conventional therapy as in the control group. The course of treatment in both groups was one month. The clinical efficacy was observed and the changes of related inflammatory indexes and hemorheological indexes were compared. Results:①The total effective rate of the treatment group was 87.5% while that of the control group was 72.5%. The clinical efficacy of the treatment group was better than that of the control group (P＜0.05). ② The levels of serum WBC, CRP, IL-6 and TNF-α in the two groups all decreased when compared before and after treatment (P＜0.05). According to the comparison between two groups after treatment, the levels of WBC, CRP, IL-6 and TNF-α in the treatment group were lower than those in the control group (P＜0.05). ③There were significant differences in the levels of whole blood high shear viscosity, whole blood low shear viscosity, plasma viscosity, hematocrit and erythrocyte electrophoresis speed in the treatment group before and after treatment (P＜0.05), but there was no significant difference in the levels of above indexes in the control group (P>0.05). After treatment, the levels of whole blood high shear viscosity, whole blood low shear viscosity, plasma viscosity and hematocrit in the treatment group were lower than those in the control group (P＜0.05), and the erythrocyte electrophoresis speed was higher than that in the control group (P＜0.05). Conclusion:Compared with conventional therapy alone, the combined use of conventional therapy and Tongsaimai tablets can achieve more satisfactory effect on diabetic food treatment as Tongsaimai tablet can better inhibit inflammatory reaction and improve microcirculation.关键词：diabetic foot;inflammation;integrated traditional Chinese and Western medicine therapy;Tongsaimai tablet;Hemorheology;microcirculation
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发布时间：2022-08-31 - 摘要：Objective:To study the feasibility of zebrafish as a drug screening model for the treatment of obesity and the effect of Jianpi Shugan Jiangzhi recipe on lipid metabolism of obese zebrafish. MethodsZebrafish fertilized for 14 days were divided into control group, model group(0 mg/L), high-dose group(1 600 mg/L), medium-dose group(400 mg/L)and low-dose group(100 mg/L).The control group was normally fed, and the other four groups were overfed. After overfeeding, the zebrafish were soaked in the corresponding concentration of medicinal solution for 8 h per day.After 56 days of drug intervention, the body length and mass of zebrafish were measured to calculate the fullness. The concentration of triglyceride and total cholesterol as well as the degree of histological degeneration and fat accumulation in the liver of zebrafish were detected. Results:The mass, fullness and the concentration of triglyceride of zebrafish in the model group were higher than those of the control group(P<0.05), while the indexes of the zebrafish in the high-dose group were significantly lower than those in the model group(P<0.05).The concentration of triglyceride in the medium-dose group was significantly lower than that in the model group(P<0.05). The liver histological degeneration and fat accumulation in the model group were obvious. The histological degeneration and fat accumulation of zebrafish in the Jianpi Shugan Jiangzhi recipe group were less than those in the model group. Conclusion:Zebrafish can be successfully used to establish obesity model and Jianpi Shugan Jiangzhi recipe can effectively reduce the fat level of zebrafish.关键词：obesity;zebrafish;Jianpi Shugan Jiangzhi recipe;lipid metabolism
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发布时间：2022-08-31 - 摘要：Objective:To investigate the protective effects of Picrorhiza scrophulariiflora (PS) on photoreceptor cell degeneration induced by light injury. MethodsBALB/c mice were randomly divided into five groups: normal control group (No Light), light damage group (Light_Vehicle), low-dose PS treatment group (Light_HHL_L), medium-dose PS treatment group (Light_HHL_M) and high-dose PS treatment group (Light_HHL_H), with 6 mice in each group. The normal control group and the light damage group were gavaged with 200 μL pure water solution per 20 g of murine body mass. The low (167 mg/kg), medium (500 mg/kg) and high (1.5 g/kg) dose groups of PS were received decoction of PS with 200 μL per 20 g of murine body mass. The mice were treated for continuous 7 days. All mice began to receive dark adaptation on the 4th day. On the 7th day, the PS treatment groups and light damage group were exposed to bright light for 30 min after intragastric administration. Seven days after illumination, the optical coherence tomography (OCT) imaging was performed to detect the thickness of retinal outer retinal nucleus layer (ONL) in vivo. The hematoxylin-eosin (HE) staining was used to observe the changes of retinal morphology and structure. Electroretinogram (ERG) was used to analyze the amplitude changes of a wave and b wave, which reflected the retinal function. The immunohistochemical assessment of Rhodopsin and M-opsin protein were performed to observe the rod and cone cells. Retinal apoptosis cells were observed in situ by TUNEL assay. Results:The retinal morphology and structure were intact and the cell nuclei were neatly arranged in the normal control group, and the amplitudes of a wave and b wave in scotopic ERG increased with stimulus intensity, and the expressions of rhodopsin and m-opsin were normal. No apoptotic cells were found in all layers of the retina. Compared with the normal control group, the retinal structure was significantly damaged and the thickness of retinal ONL was significantly thinner (P＜0.01) in the light damage group.The cell nuclei in ONL were loosely arranged and disordered, and the amplitudes of a and b waves of scotopic ERG were significantly reduced (P＜0.05).The expression of rhodopsin and M-opsin decreased significantly. A large number of apoptotic cells were observed in ONL. Compared with the light damage group, the retinal morphology and structure remained intact and the ONL nuclei were arranged neatly in the high dose PS treatment group. PS could effectively inhibit the thinning of ONL thickness (P＜0.01) and the decrease of a wave and b wave (P＜0.05).The expressions of Rhodopsin and M-opsin were significantly increased in the PS treatment groups and few apoptotic cells were observed in ONL. ConslusionThe apoptosis of photoreceptor cells induced by light injury is significantly inhibited by the intervention of PS, and PS has a significant protective effect on the retinal morphological structure and visual function in bright light-damaged mice.关键词：Picrorhiza scrophulariiflora;photoreceptor cell;retinal degeneration;mice
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发布时间：2022-08-31 - 摘要：Objective:To explore the effects and compatibility regularity of Weichang’an recipe (WCAR)and its disassembled recipes with different efficacious components on the growth and metastasis of orthotopic transplanted tumor in nude mice with gastric cancer in vivo. MethodsAccording to its efficacy, WCAR was divided into three components: Jianpi Liqi (JPLQ, invigorating spleen and regulating qi), Qinre Jiedu(QRJD, clearing away heat and removing toxin) and Ruanjian Sanjie(RJSJ, softening hardness and dissipating mass). A 2*2*2 factorial experiment was designed to establish an orthotopic transplantation model of human gastric cancer in nude mice and to observe the effects of different effective components of WCAR on inhibiting the growth and metastasis of gastric cancer and whether there is interaction between them. Results:①The tumor inhibition rates of the WCAR group, the JPLQ group, the RJSJ group and the Jianpi Qingre(JPQR, invigorating spleen and clearing away heat) group were 28.5%, 24.6%, 28.8% and 30.2%, respectively.The tumor weight in these groups were significantly reduced compared with the model group(P＜0.05).The factor of the RJSJ had the main effect in inhibiting the weight of tumor, and there was an interaction between the JPLQ factor and the RJSJ factor.②The metastasis rates of the WCAR group, QRJD group and JPQR group were 22.22%, 10.00% and 18.18% respectively, which were obviously reduce the metastasis rate of gastric cancer in nude mice compared with 75% of model control group(P＜0.05).③The expression of MMP-2 protein was inhibited in the WCAF group and its disassembled recipe groups except the RJSJ group,especially in the JPLQ group and the WCAR group(P＜0.05). There was the most obvious inhibitory effect on the expression of MMP-9 protein in the Jianpi(JP, invigorating spleen) group, JPQR group and WCAR group(P＜0.05).The results of factorial analysis showed that in the presence of RJSJ factor, the factors of JPLQ and QRJD had a synergistic effect on down-regulating the expression of MMP-2 protein.The WCAF and its disassembled recipes could inhibit the expression of MMP-2 gene in gastric tumor tissue of nude mice in varying degrees, especially in the WCAR group, Jianpi Ruanjian(JPRJ, invigorating spleen and softening hardness) group and Qingre Ruanjian(QRRJ, clearing away heat and softening hardness) group(P＜0.01). The results showed that there was interaction between the group of JPLQ combined with QRJD and the group of QRJD combined with RJSJ on the inhibition of MMP-2 gene expression. The WCAR group and JPRJ group had obvious inhibitory effect on the expression of MMP-9 mRNA in gastric tumor tissue of nude mice(P＜0.01). The factor of JPLQ combined with QRJD and the factor of JPLQ combined with RJSJ had interactive effect on the inhibition of MMP-9 mRNA expression.The WCAF group and JPLQ group significantly inhibited the activities of MMP-2 and MMP-9 in gastric tumor tissue of nude mice(P＜0.01).The results of factorial analysis showed that in the presence of QRJD factor, the factors of JPLQ and RJSJ had a synergistic effect in inhibiting the activities of MMP-2 and MMP-9, while in the absence of QRJD factor, The JPLQ and RJSJ factors had antagonistic effects in inhibiting MMP-2 and MMP-9 activities. Conclusion:The WCAR group, QRJD group has JPQR group cansignificantly inhibit the growth and metastasis of gastric cancer in nude mice, and the QRJD group has the most obvious inhibitory effect on the metastasis of gastric cancer. The JPLQ factor has significant inhibitory effect on tumor weight and the factors of JPLQ and RJSJ have interaction in inhibiting tumor weight.The results of factorial analysis show that JPLQ and QRJD factors have a synergistic effect on down-regulating the expression of MMP-2 protein in the presence of RJSJ factor, and the factors of JPLQ and QRJD had antagonistic effect on the down-regulation of MMP-2 protein expression in the absence of RJSJ factor. In the presence of QLJD factor, JPLQ and RJSJ factors have a synergistic effect on inhibiting the activities of MMP-2 and MMP-9, while in the absence of QLJD factor, JPLQ and RJSJ factors have antagonistic effects on the inhibition of MMP-2 and MMP-9 activities.关键词：Weichang’an recipe;compatibility study;gastric cancer;MMP-2;MMP-9;cancer metastasis;mice
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发布时间：2022-08-31 - 摘要：Objective:To observe the effect of lycium barbarum polysaccharide (LBP)on the reproductive damage of hypoandrogen male sterile rats,and to evaluate the efficacy and possible mechanism of LBP in the treatment of hypoandrogen male sterility. MethodsMale adult SD rats were randomly divided into blank control group,model control group,low-dose and high-dose LBP group. The model was made by intragastric administration of dutasteride 40 mg / kg once a day for 28 days,and LBP was given by gavage at the 15th day of modeling. LBP 80 mg / kg and 40 mg / kg were given in the high-dose and the low-dose LBP groups respectively and the model control group was given the same amount of vehicle for 14 days. At the end of administration,testicular and epididymal histology, ultrastructure, sperm activity,pregnancy rate,serum androgen level,epididymal androgen receptor (AR)and nuclear factor kappa-B (NF-κB)protein were detected. Results:compared with the model control group,the sperm viability and forward movement rate in the high-dose LBP group were significantly higher (P＜0.05). The pregnancy rate was 37.5% and 62.5% in the low-dose and the high-dose LBP group,respectively,which was 25% and 50% higher than that in the model control group. The epididymal epithelial junction was broken and sperms gathered in the epididymis in the model control group. The epididymal epithelial structure and sperm arrangement were recovered to a certain extent in the low-dose LBP group and the epididymal epithelium and sperms in the high-dose LBP group basically recovered to normal. The serum dihydrotestosterone(DHT) in the both LBP groups was significantly higher than that in model control group (P＜0.05,P＜0.01); the expression of AR and NF-κB protein in the both LBP groups was significantly higher than that in model control group(P＜0.05,P＜0.01). Conclusion:LBP can improve the fertility of hypoandrogenic epididymal infertility rats,which may be related to the increase of serum DHT level,the promotion of AR and NF-κB expression and the exertion of androgen like activity.关键词：infertility;hypoandrogen;rats;lycium barbarum polysaccharide;dihydrotestosterone(DHT);epididymal androgen receptor;nuclear factor kappa-B(NF-κB)
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发布时间：2022-08-31 - 摘要：Objective:To investigate the mechanism of Hubei pneumonia No.1 formula in the treatment of coronavirus disease 2019(COVID-19). MethodsWith the Chinese Medicine System Pharmacology Database Platform(TCMSP),the chemical constituents and action targets of Hubei pneumonia No.1 formula were screened. Through the gene expression profiles of peripheral blood mononuclear cells from the SARS infected patient,the SARS differential genes were analyzed,and the intersection of corresponding target and the SARS target was obtained through the Venny tool,that is,the therapeutic target. And Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway enrichment analysis and gene ontology(GO)functional enrichment analysis were performed by R 3.6.1 clusterProfile to predict the potential mechanism. Auto Dock Vina 1.1.2 was used for molecular docking to study the interactions of each chemical component with SARS-CoV-2 3CL hydrolase(Mpro). Results:A total of 108 potential therapeutic components were screened,and a total of 34 core therapeutic components were screened. The therapeutic targets involved HSP90AA1,CASP8,FASLG,CYP19A1,MAPK14,etc.61 pathways were related to COVID-19(P<0.05)in KEGG pathways enrichment screening,including inflammatory mediator pathways of TRP channels,T cell receptor signaling pathways,apoptotic pathways,B cell receptor signaling pathways and so on. The results of molecular docking showed that glyasperin F,glabrene,oroxylin a,5,7,4′-trihydroxy-8-methoxyflavone,acacetin and baicalein had strong affinity with SARS-CoV-2 3CL hydrolase(Mpro). Conclusion:Hubei pneumonia No.1 formula participates in many immune and inflammatory pathways,and may treat COVID-19 by balancing immunity and anti-inflammatory factors. Eight core therapeutic components may have potential anti-COVID-19 effects.
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发布时间：2022-08-31 -
Analysis of TCM formulation rules of transnasal therapy formulas for ancient epidemics and COVID-19
摘要：Objective:To analyze the formulation characteristics of transnasal therapy formulas for coronavirus disease 2019 (COVID-19), evaluate the inheritance relationship between COVID-19 transnasal therapy formulas and ancient ones for epidemics, and further explore the formulation rules of TCM transnasal therapy formulas for epidemic diseases. MethodsThrough searching the Chinese Medical Classics, 210 literature items of 48 ancient books in 5 historical periods were obtained, and 132 transnasal treatment formulas for ancient epidemic diseases (including 62 burning fumigation formulas, 63 volatile formulas and 7 decoction formulas) were screened out. Through searching the official websites and research documents of health departments at the municipal level and above all over the country, 20 formulas (including 12 volatile formulas and 8 decoction formulas) for COVID-19 were collected. The software of “Traditional Chinese Medicine Inheritance Assistance Platform” was used to process and analyze various formulas. Results:①There were 178 kinds of medicinal materials involved in the ancient transnasal therapy for epidemic diseases, 25 kinds of which had a use frequency of no less than 10 times, and Xionghuang (Realgar) was a single medicinal with the highest use frequency. Among them, 103 burning fumigation formulas were involved, 28 formulas of which had a use frequency more than or equal to 5 times. Xionghuang (Realgar) was the one single medicinal with the highest use frequency. Xionghuang (Realgar) and Cihuang (Orpiment) was the pair with the highest use frequency. The core formula was composed of “Xionghuang (Realgar), Zhusha (Cinnabaris) and Cihuang (Orpiment)”. The volatile formulas involved 142 kinds of medicinal materials, 30 of which had a use frequency more than or equal to 5 times. Xionghuang (Realgar) was still the one most frequently used. Zhusha (Cinnabaris) and Cihuang (Orpiment) was the pair used the most frequently. The core formula was composed of “Xionghuang (Realgar), Zhusha (Cinnabaris), Cihuang (Orpiment) and Guijianyu (Euonymus alatus)”. There were 17 kinds of medicinal materials in 7 decoction formulas, of which Taozhi (Ramulus Pruni) had the highest use frequency. ②In 20 transnasal therapy formulas for COVID-19, there were 22 kinds of medicinal materials, 18 kinds of which were used more than or equal to 2 times, and Aiye (Folium Artemisiae Argyi) was the most frequently used. Among them, the volatile formulas involved 18 kinds of medicinal materials, 13 kinds of which had a use frequency more than or equal to 2 times, and the herb with the highest frequency was Huoxiang (Agastache rugosa). The decoction formulas involved 13 kinds of medicinal materials, 7 kinds of which had a use frequency more than or equal to 2 times, and the herb with the highest frequency was Aiye (Folium Artemisiae Argyi). Conclusion:sTransnasal therapy for ancient epidemics mainly used burning fumigation formulas and volatile formulas which made good use of minerals and used diverse varieties of medicinals. However, transnasal therapy for COVID-19 mainly use volatile formulas and decoction formulas composed of herbs, and medicinals used are less in variety than that of ancient formulas. The burning fumigation method hasn’t been fully applied. It is believed that transnasal therapy formulas for COVID-19 have inherited ancient epidemic prevention experience and embody the application of ancient transnasal therapy formulas, but there are also obvious research shortcomings. It is suggested to promote the research on TCM transnasal therapy for epidemic prevention and treatment to provide new support for the participation of TCM in the construction of modern epidemic disease prevention and control system.关键词：COVID-19;SARS-CoV-2;epidemic;transnasal therapy formula;aromatic traditional Chinese medicine;formulation rule;burning fumigation- 7
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发布时间：2022-08-31 - 摘要：Objective:To observe the effect of auricular point pressing bean therapy on anxiety in patients with ordinary community acquired pneumonia during the coronavirus disease 2019 (COVID-19) pandemic. MethodsEighty-two patients with ordinary community acquired pneumonia who were excluded from COVID-19 by fever clinic were randomly divided into treatment group (42 cases) and control group (40 cases). Both groups received standard treatment for the primary disease, while the treatment group simultaneously received auricular point pressing bean therapy. The course of treatment in both groups was 7 days. The severity of the disease was assessed by the CURB-65 scores. The anxiety status of the patients was assessed by Self-Rating Anxiety Scale (SAS) and the health status of the patients was assessed by EuroQol Five Dimensions questionnaire (EQ-5D). Results:①After treatment, the CURB-65 scores of the two groups were improved (P<0.05), but there was no significant difference between the two groups (P>0.05). The hospitalization time of the two groups has no significant(P＞0.05).②The SAS score decreased significantly (P<0.05) and EQ-5D score increased significantly (P<0.05) in the treatment group after treatment, but the SAS score and EQ-5D score in the control group did not change significantly after treatment (P>0.05). After treatment, there were significant differences in SAS score and EQ-5D score between the two groups (P<0.05). Conclusion:Auricular point pressing bean therapy can obviously reduce the anxiety level of patients with ordinary community acquired pneumonia during COVID-19 pandemic, and improve negative emotions and the overall health status of patients.关键词：community acquired pneumonia;COVID-19;anxiety;auricular point;external treatment of traditional Chinese medicine;clinical research
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发布时间：2022-08-31 - 摘要：To review the current status of research on chemical constituents of Polygonatum odoratum and its pharmacological effects.Polygonatum odoratum maily contains Polysaccharides,steroidal saponins,flavonoids,volatile oil,and has blood sugar lowering,immune regulation,anti-tumor,anti-oxidation,anti-fatigue,and delaying skin aging and other pharmacological effects.关键词：Polygonatum odoratum;chemical constituents;pharmacological effects;review
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发布时间：2022-08-31 - 摘要：To review the research progress of gallic acid on the mechanism of apoptosis of human cervical cancer HeLa cells in recent years. Gallic acid regulates the apoptosis of cervical cancer HeLa cells by regulating P53 signal pathway, regulating the change of Caspase-3 level, promoting the increase of ROS level and regulating ADAM17, EGFR, AKT/p-AKT and ERK/p-erk signal pathway.关键词：gallic acid;cervical cancer;HeLa cells;apoptosis;review
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发布时间：2022-08-31 - 摘要：Combined with the introduction of a case, the clinical experience of Professor Yan Shiyun in differential treatment of refractory relapsed acute myeloid leukemia secondary to granulocytic sarcoma is analyzed. It is considered that its pathogenesis is a febrile disease caused by latent pathogenic factors. And with syndrome differentiation of Weiqi Yingxue, Bagang and Zang-fu organs, the disease is treated with the method of combining disease and syndrome differentiation guided by the core idea of “strengthening healthy qi to eliminate pathogenic factors with flexible methods through fully grasping the pathogenesis”. Professor Yan Shiyun is adept at using empirical medicines and drugs with drastic or toxic actions, and prescribes Niuhuang Xingxiao pill to control the proliferation of leukemic cells.关键词：granulocytic sarcoma;acute myeloid leukemia;TCM therapy;experience of famous doctor;proven case;Yan Shiyun
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发布时间：2022-08-31 - 摘要：Professor Su Xiao’s experience in the treatment of systemic lupus erythematosus(SLE)was summarized. Professor Su believed that the main pathogenesis of SLE was the congenital deficiency and the deficiency of liver and kidney. In the diagnosis and treatment, we should focus on the Chinese medicine and western medicine as a reference. Treatment should be specifically based on syndromes with consideration of the complementation of both medicines. When deficiency yin in liver and kidney occured, we should emphasize nourishing yin and clearing heat. When qi stagnation and blood stasis occured, resulting in accumulating heat, we should pay attention to clearing heat and invigorating blood circulation. When there were multiple symptoms, we should consider treating all of them at the same time. Spleen and stomach were priorities of health, so we should strengthen spleen and promote stomach. We should reinforce health education to prevent disease before it occured and to prevent deterioration.关键词：systemic lupus erythematosus;nourishing yin and clearing heat;cooling blood and activating blood circulation;invigorating spleen and nourishing stomach;expert experience;Su Xiao
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发布时间：2022-08-31 - 摘要：To introduce Professor Li Chunhong’s clinical experience in the treatment of insomnia with Wenjing decoction. It is considered that the type of insomnia with mixed cold and heat and blood stasis obstructing collaterals can be treated with Wenjing decoction which has the functions of clearing the upper energizer and warming lower energizer, nourishing blood and removing blood stasis. And two proven cases are presented.关键词：insomnia;Wenjing decoction;Synopsis of Golden Chamber;expert experience;Li Chunhong
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发布时间：2022-08-31
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