最新刊期
期 8 ， 2020
- 摘要：Combined with the Diagnosis and Treatment Plan of Pneumonia Infected by Novel Coronavirus (7th trial version) promulgated by the state, the etiology and pathogenesis of COVID-19 were analyzed from the four stages of dampness, heat, toxin and deficiency. It is considered that COVID-19 can be divided into mild-syndrome (such as cold and dampness stagnation in the lung and accumulation of dampness and heat in the lung), common-syndrome (such as stagnation of dampness and toxin in the lung and cold and dampness blocking the lung), severe-syndrome (like blockage of pulmonary qi by pestilent toxin and intense heat in both qifen and yingfen), critical-syndrome (internal obstruction and external collapse), and lung and spleen qi deficiency and dual deficiency of qi and yin in convalescent stage. The diagnosis and treatment strategies and prevention ideas were discussed in each stage.关键词：COVID-19;SARS-CoV-2;epidemic;treatment based on syndrome differentiation;TCM therapy
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发布时间：2022-08-31 - 摘要：Based on the classical literature of traditional Chinese medicine (TCM) and reflections on clinical practice, we intend to explain the etiology, pathogenesis, law of transmission and change, as well as therapeutic prescriptions of coronavirus disease 2019 (hereinafter referred to as COVID-19) based on the theory of “damp epidemic”. We reckon that COVID-19 is caused by the endogenous damp toxin and exogenous epidemic pathogens, which interact with each other and contribute to the disease together; COVID-19 pandemic not only follows the law of transmission and change of Wei-Qi-Ying-Xue, but also shows the transmission and change process within triple energizers.Besides, we also put forward clinical suggestions for the TCM diagnosis and treatment of COVID-19 through reviewing, organizing and summarizing syndromes, treatment principles and methods, prescriptions and herbal medicines of “damp epidemic” in relevant TCM classics.关键词：SARS-CoV-2;COVID-19;damp epidemic;etiology and pathogenesis;law of transmission and change;traditional Chinese medicine classical literature
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发布时间：2022-08-31 - 摘要：Based on the analysis of proven cases, we discussed the ideas and methods of clearing heat and eliminating dampness in treating coronavirus disease 2019 (COVID-19) regarding the “eliminating pathogenic factors as the first and foremost principle”. It is believed that COVID-19 is a pandemic with the characteristics of “damp-heat”, which should be treated by the method of clearing heat and eliminating dampness, with “eliminating pathogenic factors as the first and foremost principle” and supplemented by the method of strengthening vital qi. Under the guidance of the theory of eliminating pathogenic factors and strengthening vital qi in traditional Chinese medicine (TCM), we can help alleviate fever and smooth bowel movement to stop the disease progress, avoid the transformation of critical and severe cases and reduce the risk of death by eliminating pathogenic factors first and treating both the lung and intestine. Therapeutic methods adopted include dispersing lung to calm panting, dredging fu organs to purge heat, and resolving dampness with aromatics, etc. We follow the principles of eliminating pathogenic factors and strengthening vital qi as well as regulating the lung, liver and spleen to improve liver function and reduce the risk of disease aggravation by using the methods of clearing heat and resolving dampness, soothing liver and invigorating spleen, cooling blood and removing blood stasis, etc. We are also dedicated to the improvement of patients’ mental and physical health by strengthening vital qi. The method of invigorating qi and spleen we adopted can fasten the negative conversion in virus nucleic acid test, shorten the course of disease and facilitate recovery.关键词：SARS-CoV-2;COVID-19;epidemic;eliminating pathogenic factors;strengthening vital qi;clearing heat and resolving dampness;simultaneous treatment of the lung and spleen;simultaneous treatment of the lung and large intestine
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发布时间：2022-08-31 - 摘要：Coronavirus disease 2019 (COVID-19) can be classified into the category of warm diseases in traditional Chinese medicine (TCM), and outthrusting method is an important therapeutic method in treating warm diseases. Based on ancient and modern literatures of TCM, COVID-19 diagnosis and treatment programs issued by National Health Commission of the People`s Republic of China and various provincial and municipal health commissions were analysed. It was believed that the outthrusting method should be applied throughout the whole treatment course of COVID-19. Outthrusting method can be widely applied to the treatment of COVID-19 patients at different stages and with different clinical types when combined with other TCM therapeutic methods properly.关键词：SARS-CoV-2;COVID-19;warm disease;outthrusting method;TCM therapy
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发布时间：2022-08-31 - 摘要：The pathological mechanism and the treatment strategy of integrated traditional Chinese and western medicine of coronavirus disease 2019 (COVID-19) complicated with cardiovascular diseases was discussed based on psychocardiology. It is believed that anxiety and depression can aggravate the condition of COVID-19 patients with cardiovascular diseases, and its mechanism may be related to the activation of renin-angiotensin system.Clinically, physical therapies such as counseling, Chinese medical exercises, five-element music and other intervention measures such as western medicine can be adopted for the treatment. Traditional Chinese medicine can also play its role by differentiating syndromes like liver qi stagnation, heart-spleen deficiency,stasis and obstruction of heart vessel, and phlegm-fire disturbing the heart and then treating them accordingly.关键词：COVID-19;SARS-CoV-2;cardiovascular disease;psychocardiology;psycho-cardiological disease;integrated traditional Chinese and western medicine treatment
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发布时间：2022-08-31 - 摘要：Objective:To analyze the clinical features and diagnosis and treatment of patients with coronavirus disease 2019 (COVID-19),explore potential factors influencing the course of disease and hospitalization days, and provide reference for traditional Chinese medicine (TCM) treatment of COVID-19. MethodsNinety-three included patients with COVID-19 were those admitted to Ward 5 and Ward 7 of Leishenshan Hospital of Wuhan city from February to March 2020. Their demographic features, medical data at the onset of COVID-19,and laboratory test were collected through questionnaire survey, and statistical analysis was carried out by SAS9.2 software. Results:The average age of 93 COVID-19 patients was 60.56 years old with the standard deviation of 12.32. Male patients accounted for 40.86%. The majority of the patients were common type (86.02%),and 42.34% of the patients were accompanied by chronic diseases. The main symptoms of COVID-19 patients at admission included fatigue (83.87%),nervousness (82.80%), depression(70.97%),dry cough (68.82%) and sleep disorder (66.67%). All patients received TCM treatment,with 44.09% also receiving western medicine treatment,41.94% receiving acupuncture treatment and 12.90% receiving auricular point/application treatment. More than 90% of the patients had no symptoms of fever,abdominal distension and anorexia when they were discharged from hospital. The average course of disease was 44.74 days with the standard deviation of 14.70, and the average hospitalization duration was 18.99 days with the standard deviation of 9.97. The course of disease of patients receiving acupuncture treatment was significantly shorter than that of patients not receiving acupuncture treatment (P<0.05),and the hospitalization days of patients receiving acupuncture treatment were also shorter than that of patients not receiving acupuncture treatment. Conclusion:Most COVID-19 cases included have no complications, and TCM intervention rate in treating COVID-19 is high. Acupuncture, as a representative of TCM treatment, can alleviate the symptoms of patients, shorten the course of disease and hospitalization days.关键词：COVID-19;SARS-CoV-2;TCM therapy;clinical feature;course of disease;hospitalization days
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发布时间：2022-08-31 - 摘要：Combined with four cases of the usual oral diseases,such as temporomandibular joint disorder, oral lichen planus, burning mouth syndrome, recurrent oral ulcer, this paper introduced Feng Xinghua’s clinical experience in the treatment of rheumatic-related oral diseases. Professor Feng believed that the treatment of these oral diseases should be based on the multi-disciplinary thinking of western medicine and the holistic concept of traditional Chinese medicine, and treated with the liver differentiation. Common prescriptions included Chaihu Shugan powder and Xiaoyao powder, etc.关键词：rheumatic disease;oral diseases;treated with the liver differentiation;medical case;famous doctor experience;Feng Xinghua
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发布时间：2022-08-31 - 摘要：To introduce Professor Sun Shidao’s clinical experience in the treatment of dermatitis and eczema.It is considered that the pathogenesis of the diseases is yang floating due to exuberant heat and impairment of qi and yin according to the syndrome differentiation of dermatitis and eczema. In the treatment of the diseases, it should be distinguished about the type of heat pathogenic factors, the degree of yang floating, and the symptoms of impairment of qi and yin. The treatment method is clearing away heat and suppressing yang to relieve itching and replenishing qi and nourishing yin to consolidate vital base. The characteristic prescriptions include Sanhuang Lishi decoction, Qinzhu Liangxue recipe, Yangyin Yiqi recipe and Sizhong decoction. And one proven case is presented.关键词：dermatitis and eczema;TCM therapy;experience of famous doctor;Sun Shidao
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发布时间：2022-08-31 - 摘要：Objective:To summarize and analyze the rules of acupoint selection and prescription for acupuncture treatment of vascular cognitive impairment (VCI) based on data mining technology, and to provide theoretical references for clinical treatment. MethodsBy searching the literatures of acupuncture treatment of VCI, a corresponding database was established, the frequency analysis of acupoints, meridian tropism, distribution and attributes of specific acupoints was carried out, and further cluster analysis and association rule analysis were conducted on high-frequency acupoints. Results:①Totally 105 articles were selected according to the criteria, involving 108 points with the total frequency of 862 times. ②The top five acupoints used frequently were Baihui (GV 20), Shenting (GV 24), Sishencong (EX-HN1), Taixi (KI 3) and Zusanli (ST 36). ③Acupoints on the Governor Vessel (GV), head and neck were the most commonly used, and crossing acupoints were the most widely used specific acupoints. ④Four effective clusters were concluded by cluster analysis, i.e., Yintang (EX-HN3)-Shuigou (GV 26)-Xuanzhong (GB 39)-Benshen (GB 13)-Dazhui (GV 14)-Fengfu (GV 16), Hegu (LI 4)-Taichong (LR 3)-Fenglong (ST 40), Xuehai (SP 10)-Zhongwan (CV 12)-Zusanli (ST 36), and Shenmen (HT 7)-Neiguan (PC 6)-Sanyinjiao (SP 6). ⑤Thirteen commonly used association groups were obtained through the analysis of association rules, of which the group with the highest confidence degree was Baihui (GV 20)-Taixi (KI 3)-Shenting (GV 24), and the group with the highest support degree was Baihui (GV 20)-Shenting (GV 24) and Baihui (GV 20)-Sishencong (EX-HN1). Conclusion:When acupuncture is used to treat VCI, acupoints on the yang meridians, head and neck are the main points to be selected and local acupoints are selected and used with both reinforcing and reducing methods to achieve the desired effects of tonifying spleen and kidney, resolving phlegm and removing blood stasis, refreshing brain and inducing resuscitation.关键词：vascular cognitive impairment;vascular dementia;acupuncture;acupoint selection rule;meridian;specific acupoint;data mining
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发布时间：2022-08-31 - 摘要：Different applications of TCM Zheng can be described by thermodynamic state. But in everyday usage of the term “state”, it tends to describe the situation that is associated with long-term or stable changes. Because of the consistence between Zheng and state, the combination of disease and Zheng is developed into the combination of state and disease differentiation with treatment, which highlights the feature that TCM not only attaches importance to disease, but also gives priority to the treatment of state in the contemporary context. It may be an important direction in the future to understand and study TCM Zheng from the point of view of state, especially thermodynamic state.关键词：TCM Zheng;disease;combination of disease and TCM Zheng;thermodynamics state
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发布时间：2022-08-31 - 摘要：Objective:To sort out the efficacy and application evolution of Haematitum(Zheshi) in the literature of materia medica and prescription books. MethodsThe evolution process of the efficacy of Haematitum was analyzed by referring to materia medica and prescription books from the Han and Tang dynasties to the present. Results:In the Han and Tang dynasties, the efficacy and applications of Haematitum had been basically determined,which had the action of dispelling pathogenic factors and detoxification,lowering adverse flow of qi and checking fright,cooling blood and stopping bleeding,reducing leucorrhea and promoting embryo discharge,and nourishing blood and tonifying qi. During the Song and Yuan dynasties,it was definite about Haematitum’s antiemetic effect. The category of its stopping bleeding effect was extended from the bleeding syndrome of lower energizer to the epistaxis of the upper energizer,the hematemesis of the middle energizer,and the profuse uterine bleeding and hematochezia of the lower energizer; its efficacy of reinforcing deficiency was divided into strengthening the spleen and securing essence. Moreover,It was also clear that it can promote granulation to astringe ulcer by external usage. In the Ming and Qing dynasties,the utility of Haematitum was divided. More attention was paid to mechanisms in that period,and the illness treated with Haematitum mostly related to fever,deficiency and reverse syndrome. The main efficiency of Haematitum in contemporary Chinese pharmacy textbooks was simplified to repressing hyperactive liver yang,descending the adverse flow of qi with heavy drugs,cooling blood and hemostasis. Conclusion:From the Han and Tang dynasties to the contemporary era,the efficacy’ parlance of Haematitum has changed from confusion to refinement and standardization, but there are both additions and omissions in the efficacy of the drug, which are worth further sorting out and making full use of.关键词：Haematitum (Zheshi);efficacy;application;evolution
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发布时间：2022-08-31 - 摘要：To introduce the similarities and differences in the differential treatment of varicella and herpes zoster with classical prescriptions. It is considered that both of them are common skin diseases caused by varicella-zoster virus(VZV) infection. For varicella, the treatment is focused on dispelling pathogenic factors by syndrome differentiation concentrated on the three yang meridians of the Taiyang, Yangming and Shaoyang in the six meridians, and gypsum associated prescriptions can be used. For herpes zoster, attention is paid to strengthening the healthy qi by syndrome differentiation focused on the six meridians, deficiency and excess, and Chaihu(Radix Bupleuri) associated prescriptions can be applied.关键词：varicella;herpes zoster;TCM therapy;classical prescriptions;syndrome differentiation of six meridians
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发布时间：2022-08-31 - 摘要：Objective:To observe the clinical study of modified Shaoyao Gancao decoction combined with tandospirone citrate in treatment of post-stroke cerebellar ataxia. MethodsOne hundred and sixteen patients with post-stroke cerebellar ataxia were randomly divided into treatment group and control group,58 patients in each group,the control group was treated with basic treatment plus tandorone citrate,and the treatment group was treated with modified Shaoyao Gancao decoction on the basis of the control group. The course of treatment in both groups was 4 weeks. The clinical efficacy,Berg Balance Scale(BBS)scores,Modified Barthel Index(MBI)scores, Transcranial Doppler(TCD) ultrasonography of the posterior inferior cerebellar artery,Hamilton Anxiety Scale(HAMA),Hamilton Depression Scale(HAMD)and adverse reactions of the two groups were observed. Results:①The total effective rate of treatment group and control group was 91.38% and 72.41%,and the clinical effect of the treatment group after treatment was better than that of the control group(P<0.05)；②BBS scores and MBI scores of the two groups after treatment were significantly higher than those before treatment(P<0.05),and the treatment group were better than those of the control group(P<0.05)；③TCD in the two groups showed that the peak systolic velocity(Vs),end diastolic velocity(Vd)and mean velocity(Vm)were significantly higher than those before treatment(P<0.05),the levels of Pulsatility Index(PI)and Resistive Index(RI)were significantly lower than those before treatment(P<0.05),and the treatment group were better than those of the control group(P<0.05)； ④The levels of HAMA and HAMD in the two groups after treatment were significantly lower than those before treatment(P<0.05), and the treatment group were better than those of the control group(P<0.05)；⑤Incidence of adverse reactions in the treatment group were lower than those in the control group(P<0.05). Conclusion:Modified Shaoyao Gancao decoction combined with tandospirone citrate has a significant effect on post-stroke cerebellar ataxia, which can improve the balance ability and activity of daily life,obviously improve the TCD level of the posterior inferior cerebellar artery and anxiety and depression,it is safety and worthy of clinical application.关键词：modified Shaoyao Gancao decoction;tandospirone citrate;post-stroke cerebellar ataxia;clinical study
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发布时间：2022-08-31 - 摘要：Objective:To observe the clinical efficacy of Bushen Huoxue decoction in the treatment of premature ovarian failure(POF)and explore its influence on the relevant immune antibody. MethodsEighty-two patients of POF were enrolled and randomly divided into the Chinese medicine group and the western medicine group,41 cases in each group.The patients in the Chinese medicine group were orally treated with Bushen Huoxue Decoction,and the patients in the western medicine group were orally treated with sequential therapy of progynova combined with medroxyprogesterone acetate.The treatment course of the two groups was 6 months. Before and after treatment, the Chinese medical syndrome scores of the two groups were compared; the levels of follicle-stimulating hormone(FSH), luteinizing hormone(LH), estradiol(E2), prolactin(PRL), progesterone(P), testosterone(T), anti-mullerian hormone(AMH), antinuclear antibody(ANA), anticardiolipin antibody(ACA)and anti-ovarian antibody(AOA)were detected; the uterine volume, ovarian volume, and the peak systolic velocity(PSV)and resistance index(RI)of ovarian stromal blood flow in the two groups were measured and compared through ultrasonic examination. Results:In the course of treatment, 4 cases in the Chinese medicine group and 2 cases in the western medicine group were eliminated, and finally 37 cases in the Chinese medicine group and 39 cases in the western medicine group were included in the statistical analysis.①After treatment, the Chinese medical syndrome scores of the two groups were significantly decreased(P<0.01), and the scores of the Chinese medicine group were lower than those of the western medicine group(P<0.01).②=2\*GB3After treatment, the level of FSH and the radio of FSH/LH in the Chinese medicine group were significantly decreased(P<0.05), the level of FSH in the western medicine group was also decreased(P<0.05), and there were no statistical differences on the levels of sex hormones between the two groups(P>0.05).③=3\*GB3After treatment, the levels of AMH in the two groups were increased(P<0.05), the levels of ANA and AOA were decreased(P<0.05), and the level of AMH in the Chinese medicine group was higher than that in the western medicine group and the level of ANA in the Chinese medicine group was lower than that in the western medicine group(P<0.05).④=4\*GB3After treatment, the ovarian volume and the PSV of ovarian stromal blood flow in the two groups were increased compared with treatment before(P<0.05), the RI in the Chinese medicine group was decreased compared with treatment before(P<0.05), and the RI in the Chinese medicine group was lower than that in the western medicine group(P<0.05). Conclusion:Bushen Huoxue decoction can effectively improve the Chinese medical syndrome of the patients with POF, down-regulate the level of FSH and the ratio of FSH/LH, up-regulate the level of AMH, regulate the ANA-ACA-AOA pathway, thereby balance the hypothalamus-hypophysis-gonad axis, alleviate the damages of ovarian granulosa cells and follicle, and relieve POF.关键词：premature ovarian failure;traditional Chinese medicine therapy;Bushen Huoxue Decoction;ANA-ACA-AOA pathway
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发布时间：2022-08-31 - 摘要：Objective:To observe the ovulation induction effect of Yushen Tongluo Granule combined with clomiphene in treating infertility patients with polycystic ovary syndrome(PCOS) of kidney-essence insufficiency type. MethodsSixty-two infertility patients with PCOS of kidney-essence insufficiency type were included and randomly divided into the treatment group(31 cases) and the control group(31 cases). The patients in both groups were orally treated with clomiphene citrate tablet from the fifth day of the menstrual cycle or progesterone withdrawal bleeding, lasting for 5 days. Based on above, the patients in the treatment group were orally treated with Yushen Tongluo Granule and the patients in the control group were orally treated with Yushen Tongluo Granule placebo after menstruation, until ovulation.The treatment course of the two groups was 3 menstrual cycles.The clinical effect of the two groups was evaluated, the pregnancy outcomes and the scores of Chinese medical syndrome were compared between the two groups, the ovulation and the endometrial thickness of ovulatory period were monitored by transvaginal ultrasound, the levels of testosterone(T), follicle stimulating hormone(FSH), and luteinizing hormone(LH), and LH/FSH ratio in unpregnant patients were compared between the two groups before and after treatment. Results:①After treatment, the total clinical effective rates of the treatment group and the control group were 96.8% and 90.3% respectively with a significantly statistical difference between the two groups(P<0.05), and the effect of the treatment group was better than that of the control group.②The ovulation rates of the treatment group and the control group were 91.5% and 75.9% respectively, and the ovulation rate of the treatment group was higher than that of the control group(P<0.05).③In the course of treatment, the clinical pregnancy rates of the treatment group and the control group were 54.8% and 35.5% respectively, with no statistical difference between the two groups(P>0.05).④After treatment, the scores of Chinese medical syndrome in the treatment group were significantly decreased(P<0.01), and the scores of the treatment group were lower than those of the control group(P<0.01).⑤During the first, second and third menstrual cycles of treatment, the endometrial thickness of ovulatory period in the treatment group was significantly thicker than that in the control group(P<0.01).⑥After treatment, the levels of T and LH, and LH/FSH ratio of the unpregnant patients in both groups were significantly decreased compared with treatment before(P<0.05), and the LH/FSH ratio in the treatment group was lower than that in the control group(P<0.05). Conclusion:Yushen Tongluo Granule combined with clomiphene has a synergistic effect in the treatment of infertility patients with PCOS of kidney-essence insufficiency type, which can obviously enhance the ovulation rates, improve the Chinese medical syndrome, increase the endometrial thickness and improve the level of sex hormone, and its total clinical effect is better than that of clomiphene alone.关键词：polycystic ovary syndrome;infertility;Yushen Tongluo Granule;clomiphene;integrated Chinese and western medicine
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发布时间：2022-08-31 - 摘要：Objective:To study the inhibitory effect of tetrandrine(TET) on the level of miR-21 on epithelial-mesenchymal transition(EMT)in ovarian cancer. MethodsHuman ovarian cancer A2780 cells, ES-2 cells and normal human ovarian epithelial IOSE80 cells were used as the research objects, MTT method was used to determine the effects of 0,1.0,2.0,5.0,10.0,20.0 μmol/L TET on the proliferation of three kinds of cells. The experiment was divided into IOSE80 cell control group, A2780 cell control group, ES-2 cell control group, A2780 cell group with TET, ES-2 cell group with TET. The expression level of miR-21 was measured by real-time quantitative PCR(RT-qPCR). The effects of TET on cell migration and invasion were studied by migration and invasion experiments, and the expressions of GSK3β, p-gsk3β, β-Catenin, E-cadherin, N-cadherin and vimentin were measured by Western blot. Results:Compared without TET, the survival rates of A2780 cells and ES-2 cells decreased significantly with the increase of TET concentration(P<0.05)when TET concentration was 1.0~20.0 μmol/L, the concentrations of TET on A2780 cells and ES-2 cells were 5.0 μmol/L and 3.0 μmol/L respectively for the follow-up experiments. Compared with IOSE80 cell comtrol group, the expression level of miR-21 in A2780 cell control group and ES-2 cell control group increased significantly (P<0.05). Compared with the A2780 cell control group and ES-2 cell control group, the miR-21 expression level, migration ability, invasion ability, GSK3 protein phosphorylation level, β-Catenin protein expression level, N-cadherin protein expression level and vimentin protein expression level in the A2780 cell group and ES-2 cell group were significantly reduced(P<0.05), and the expression level of E-cadherin protein increased significantly(P<0.05). Conclusion:TET may block Wnt/β-catenin signaling pathway and inhibit EMT of ovarian cancer by down regulating miR-21 expression.关键词：ovarian cancer;tetrandrine;epithelial-mesenchymal transition;miR-21
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发布时间：2022-08-31 - 摘要：Objective:To investigate the effects of chamomile ethanol extraction on the blood glucose of streptozotocin(STZ)-induced type 2 diabetes model mice. And anti-oxidation capacity of chamomile extracts in normal mice and the anti-oxidation in vitro were also determined. MethodsThe ethanol extraction(CT) of chamomile was extracted by refluxing with ethanol. The water extract(ST) of chamomile was extracted by decoction. And the total flavonoids(HT) of chamomile were purified by macroporousresin. High sugar and high fat diet combined with STZ was used to establish a type 2 diabetic mice model. High, medium and low dose ethanol extractions were given by gavage. Two weeks later, the changes of blood glucose and glucose tolerance before and after administration were detected. Normal mice were used for antioxidant experiments. High, medium and low dose of ST and CT and HT were given by gavage. After 21 days, SOD and MDA and GSH-PX were detected in the serum of mice. The scavenging rate of chamomile ethanol extractions on various free radicals was measured to evaluate in vitro antioxidant capacity of chamomile ethanol extractions. Results:Compared with the model group, the metformin hydrochloride group and CT high and middle dose groups were significantly different(P<0.01, P<0.05). In the glucose tolerance experiment, compared with the model group, the blood glucose value of diabetic mice at each time point were reuduced significantly in Metformin hydrochloride group and CT high and middle groups(P<0.01, P<0.05). In the antioxidant experiment, compared with the normal group, the SOD and GSH-PX in the serum of mice were increased and the MDA content was reduced(P<0.01, P<0.05). In the antioxidant experiment in vitro, the extractions of chamomile at a concentration of 1.0 mg/mL showed its certain scavenging ability to DPPH· and O-2·, but it had no effect in scavenging ·OH radicals. Conclusion:sChamomile extractions had good hypoglycemic and antioxidant effects.关键词：type 2 diabetes;chamomile extractions;hypoglycemic;antioxidant
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发布时间：2022-08-31 - 摘要：Non-alcoholic fatty liver disease (NAFLD) is a disease characterized by excessive accumulation of liver fat in patients with less or no alcohol consumption. Autophagy is an evolutionary conserved intracellular degradation function, which is of great significance to hepatic homeostasis and can delay the occurrence and development of NAFLD to a certain extent. Based on autophagy regulation, the mechanism of action in the treatment of NAFLD was reviewed from three aspects:traditional Chinese medicine (TCM) compound formulas, TCM crude extracts and TCM active components. It was found that TCM can inhibit the occurrence and development of liver steatosis and NAFLD by regulating autophagy of hepatocytes. It was also believed that TCM induced autophagy of hepatocytes may be a new therapeutic strategy for NAFLD. In the conclusion part, the limitations of the current research and the challenges faced by TCM modernization were pointed out for the purpose of providing information for the future innovative drug research and treatment development of NAFLD.关键词：non-alcoholic fatty liver disease;autophagy;TCM compound formula;TCM extracts;TCM active components;literature review
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发布时间：2022-08-31 - 摘要：The progress was reviewed on Zinc-ZIP8-MTF1 signal pathway in the pathogenesis of osteoarthritis and the mechanism of traditional Chinese medicine. There was an association of zinc(Zn2＋)homeostasis, Zn2＋transporters, and Zn2＋-dependent transcription factors with cartilage injury. Futhermore, the Zinc-ZIP8-MTF1 signal pathway could regulate the occurrence and development of osteoarthritis.Until now, the research of traditional Chinese medicine in this field is limited to the regulation of Zn2+ level, and is unknown about the influence on ZIP8 and MTF1. Therefore, it has important role in the treatment for OA to study the effect of traditional Chinese medicine on zinc-zip8-mtf1 signal pathway.关键词：osteoarthritis;Zinc-ZIP8-MTF1 signal pathway;matrix metalloproteinase;traditional Chinese medicine;reivew
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发布时间：2022-08-31 - 摘要：Radix Codonopsis, in the family Campanulaceae, is a kind of tonic Chinese medicine with dual use of medicine and food. It mainly contains alkaloids, alkynes, terpenoids, flavonoids, saccharides and other chemical components, and has pharmacological effects on nervous system, endocrine system, immune system and digestive system. The chemical constituents, pharmacoloaical action, quality control of Codonopsis were summarized in order to provide the basis for the clinical application and daily health products of Codonopsis.关键词：Radix Codonopsis;chemical constituents;pharmacological action;quality control;reivew
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发布时间：2022-08-31
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