最新刊期
期 4 ， 2020
- 摘要：This paper introduces the clinical experience of Professor Wang Qingqi in using the theory of Huangdi Neijing (Yellow Emperor’s Canon of Medicine) to distinguish and treat depression syndrome. Depression syndrome has broad and narrow sense. According to yin and yang syndrome differentiation, depressive disorder belongs to yin syndrome while anxiety disorder belongs to yang syndrome. Because of the close relationship between depression syndrome and spleen, the concept of “emotion-related spleen-stomach disease” is put forward, which is divided into three categories: depression-related spleen-stomach disease, anxiety-related spleen-stomach disease and cognitive bias-related spleen-stomach disease. It is emphasized that the treatment of depression syndrome follows the principle of “wood depression treated by relief therapy ”, “fire depression treated by dissipating therapy” and nourishing the heart and tonifying the kidney. And in combination with psychotherapy, the treatment has achieved good results with self-made prescription such as Xuanyang Huatan Kaiyu decoction, Zhizi Xiaolyu decoction, Yangxin Yishen Dingzhi decoction.关键词：depression syndrome;Huangdi Neijing (Yellow Emperor’s Canon of Medicine);emotion-related spleen-stomach disease;depressive disorder;anxiety disorder;experience of famous doctors;Wang Qingqi
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发布时间：2022-08-31 - 摘要：Integrated Chinese and western medicine plays a unique role in the prevention and treatment of coronavirus disease 2019(COVID-19). At the same time, a lot of clinical research of Chinese medicine have been registered in China. A series of problems of scientific nature, standardization, and operability became emerging and disputed. The clinical researches should be conducted with overall consideration of the characteristics of Chinese medicine R & D, the dynamic epidemic condition and the scientific basis. Reasonable clinical indication is the key to the development of Chinese medicine against COVID-19, based on the collection of front-line reliable Chinese medicine diagnosis and treatment information. With the patient’s maximum benefit as the core and under the premise of not affecting the epidemic prevention and control, operable and adaptable clinical research protocols are needed with scientific and ethical consideration. The scientific supervision system should also be established for emergency conduct of clinical trials of new Chinese medicines in major emerging public health events. Taken together, real and reliable research results of effectiveness and safety of Chinese medicines are anticipated by scientific and rigorous clinical researches.关键词：COVID-19;SARS-CoV-2;Chinese medicine;clinical research
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发布时间：2022-08-31 -
- 摘要：The clinical foundation of traditional Chinese medicine (TCM) was laid in the process of dealing with febrile diseases (epidemic diseases). The opposition between Wenyi (febrile contagious diseases) and Shanghan (cold-evil induced diseases) in history was to explore more effective clinical treatment methods. Although the diagnosis and treatment of epidemic diseases are special, the principles and rules of the six-channel pattern identification and treatment are still the basics. Mastering the methods of the six-channel pattern identification and corresponding treatment is helpful for the understanding and application of TCM diagnosis and treatment program for coronavirus disease 2019 (COVID-19).关键词：Wenyi (febrile contagious disease);Shanghan (cold-evil induced disease);six-channel pattern identification and treatment;COVID-19;SARS-CoV-2
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发布时间：2022-08-31 - 摘要：Objective:To explore the thoughts and clinical experience of doctors in Tang and Song dynasties in diagnosing and treating epidemic diseases by using the methods of literature collation and data mining. MethodsThis study chose representative works in traditional Chinese medicine of Tang and Song dynasties－Waitai Miyaofang(Medical Secrets of an Official), Qianjin Yaofang(Invaluable Prescriptions for Ready Reference),Taiping Shenghuifang (Peaceful Holy Benevolent Prescriptions)and Taiping Huimin Hejijufang(Prescription of Peaceful Benevolent Dispensary) as the research object to extract the prescriptions and Chinese medicines for the treatment of epidemic diseases in the four books by using the methods of literature collation and data mining, and then deeply analyzed the Chinese medicines which were used frequently, and summarized the commonly used Chinese medicines and their compatibility by the method of correlation intensity. Results:Gancao(Radix Glycyrrhizae), Huangqin (Radix Scutellariae) and Maidong(Radix Ophiopogonis) were the most commonly used Chinese medicines for the treatment of pestilence； Changshan(Radix Dichroae), Gancao(Radix Glycyrrhizae) and Biejia(Carapax Trionycis) were the most commonly used for the treatment of malaria； Renshen(Radix Ginseng), Gancao(Radix Glycyrrhizae) and Shengjiang(Herba Stelmatocryptonis Khasiani) were the most commonly used for the treatment of cholera. In the total Chinese medicines for the treatment of epidemic diseases, tonic Chinese medicines accounted for 30%, mainly tonifying qi and yin, followed by surface-relieving Chinese medicines (20%), and heat-clearing Chinese medicines (12%) accounted for the same proportion as warming the interior Chinese medicines (11%). Conclusion:According to the theory of syndrome differentiation through formula effect assessment, it can be inferred that the pathogenesis of qi deficiency, yin deficiency, cold and heat may appear in the epidemic diseases in the Tang and Song dynasties, and strengthening the healthy qi and dispelling pathogens is the main treatment principle of the epidemic diseases in this period.关键词：epidemic diseases;Tang and Song dynasties;TCM therapy;medication rule;data mining;COVID-19;SARS-CoV-2
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发布时间：2022-08-31 - 摘要：The clinical significance of treating the lung and intestine together in severe coronavirus disease 2019(COVID-19)was explored from the perspective of “lung and large intestine forming an exterior and interior relationship”. According to the onset characteristics and clinical symptoms of COVID-19, gastrointestinal symptoms were another major manifestations besides respiratory symptoms. The effect of simultaneous treatment of both the lung and intestine was especially significant in severe cases. Furthermore, the rationality and feasibility of simultaneous treatment of the lung and intestine for severe COVID-19 was expounded from the aspects of traditional Chinese medicine theory and modern medicine mechanism research. Representative TCM prescriptions for treating both the lung and intestines including Chenqi decoctions(Da Chenqi decoction, Xiao Chenqi decoction, Tiaowei Chenqi decoction and Xuanbai Chenqi decoction), Liangge powder and Shengjiang powder, etc., can be used in the treatment of severe COVID-19.
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发布时间：2022-08-31 - 摘要：Based on the coronavirus disease 2019 clinical symptoms,pathogenesis characteristics and syndrome differentiation and other related data in Liaoning Shenyang area and Hubei Xiangyang area,we found that the coronavirus disease 2019 was characterized by both wet and cold,determination of etiologic factors based on differentiation.It is believed that the south and the north have different emphases,the south focuses on “wet”,and the north focuses on “cold”.In the process of diagnosis and treatment in Liao Shen area,it is suggested that we should combine the regional seasonal characteristics with three categories of etiologic factors to seek common ground while reserving differences.According to the clinical manifestations of light,common,severe and critical types,we could treat them by syndromes differentiation based on different periods.Combined with the differences of individual constitution,we should explore the process of the integration of evil spirits,and argue and treat them according to constitution.Using six meridians dialectically to prevent disease transmission.At the same time,we should pay attention to prevention and reasonable care.关键词：COVID-19;SARS-CoV-2;treatment of traditional Chinese medicine;three categories of etiologic factors;Liao Shen area
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发布时间：2022-08-31 - 摘要：Objective:To observe retrospectively the clinical efficacy of integrated traditional Chinese and western medicine in the treatment of non-critical coronavirus disease 2019 (COVID-19) patients,compared with western medicine therapy. MethodsSixty-seven patients with COVID-19 admitted to Shanghai Public Health Clinical Center were divided into the western medicine group(n=18) and the integrative medicine group(n=49) according to different therapies. The western medicine group was given oxygen therapy, antiviral and symptomatic support treatment, while patients with severe condition were given anti-inflammatory, immune regulation and intravenous immunoglobulin (IVIG) support treatment. Besides the adoption of the same treatment in the western medicine group, the integrative medicine group was also administered with Chinese patent medicine or decoction orally. The clinical data of the two groups of patients, including general conditions, relevant laboratory indexes, imaging manifestations, symptom information, and TCM pattern information (including tongue and pulse) were collected and analyzed. The clinical efficacy related indexes of the two groups of patients were observed and compared, including antipyretic time, clinical symptom score, CT improvement rate, critical case conversion rate, hospitalization time and total course of disease. Results:①There was no significant difference in the general conditions, relevant laboratory indexes and imaging manifestations between the western medicine group and the integrative medicine group (P>0.05). ②All patients received antiviral treatment, and 27.78% were treated with antibiotics in the western medicine group,while 34.69% in the integrative medicine group. ③The main manifestations of the patients were fever (71.64%), cough/dry cough (52.24%), fatigue (47.76%), poor appetite (35.82%), sore/itching throat (31.34%), white/yellow sputum (26.87%), sweating (25.37%), diarrhea (22.39%), nasal obstruction (13.43%), and headache/dizziness (13.43%). There was no significant differences between the two groups(P>0.05).④In the integrative medicine group, 32 cases (65.31%) had damp toxin stagnating the lung pattern and 17 cases (34.69%) had heat toxin blocking the lung pattern. Patients with red or pale red tongue color, white and greasy tongue coating and slippery pulse were more commonly seen in the clinic. ⑤There were significant differences in hospitalization days and clinical symptom scores on the 6th day of admission between the integrative medicine group and the western medicine group (P<0.05). However, there was no significant difference in the total course of disease, antipyretic time and CT improvement rate on the 6th day of admission between the two groups (P>0.05). ⑥During the observation period, there was no case transforming to the critical condition in both groups. Conclusion:The integrated Chinese and western medicine treatment has shown great advantages in shortening the hospitalization time and improving the main clinical symptoms of patients with COVID-19 such as fever, cough and fatigue.关键词：COVID-2019;SARS-CoV-2;integrated Chinese and western medicine treatment;curative effect observation;retrospective analysis
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发布时间：2022-08-31 - 摘要：The clinical experience of treating an elderly patient with severe coronavirus disease 2019 (COVID-19) from the angle of treating damp-warm disease was introduced. In the early stage the pathogenic factors were in the pleuro-diaphragmatic interspace; in the advanced stage the damp pathogenic factor obstructed the lung; in the severe stage the pathogenic factors entered the nutrient-blood phase and in the recovery stage the residual heat gradually receded. Under the routine treatment of western medicine, the simultaneous treatment with Dayuan decoction and Sanren decoction based on Chinese medicine pattern identification is helpful to improve the clinical curative effect by clearing heat, removing dampness and expelling pathogenic factors from the pleuro-diaphragmatic interspace.
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发布时间：2022-08-31 - 摘要：Objective:To systematically evaluate the clinical efficacy and safety of Xuanbai Chengqi decoction (XBCQD) in the treatment of severe pneumonia of phlegm-heat obstructing lung pattern. MethodsCNKI, Wanfang Data Knowledge Service Platform, VIP, SinoMed, EMbase, PubMed, the Cochrane Library and other databases were searched systematically. According to the pre-set inclusion and exclusion criteria, the clinical randomized controlled trials (RCTs) research literatures were screened, the research quality was evaluated by risk assessment tools, and the data were extracted and meta-analyzed by RevMan 5.3 and R 3.6. 1 software. Results:A total of 11 papers involving 882 patients were included. Meta-analysis results showed that compared with the routine treatment of western medicine alone, the modified XBCQD can improve the total effective rate [OR=5. 19,95% CI (3.33, 8.07), P<0.000 01], reduce the lactic acid content in peripheral arterial blood [WMD=-2.04,95% CI(-2.30,-1.79), P<0.000 01], invasive mechanical ventilation time [WMD=-125.33,95% CI(-132.21,-118.44), P<0.000 01], clinical pulmonary infection score [WMD=-1.93, 95% CI(-2.29, -1.57), P<0.000 01], acute physiological and chronic health II score [WMD=-7.94,95% CI(-8.47,-7.41), P<0.000 01]. Only 2 papers reported adverse reactions. The results showed that there was no obvious adverse reaction in the treatment of severe pneumonia of phlegm-heat obstructing lung pattern with modified XBCQD on the basis of conventional western medicine therapy. Conclusion:The application of XBCQD on the basis of conventional western medicine therapy to treat severe pneumonia of phlegm-heat obstructing lung pattern can improve clinical efficacy and life quality of patients compared with conventional western medicine therapy alone. However, as the quantity and quality of literatures included were limited, the relevant conclusions need further verification.关键词：Xuanbai Chengqi decoction;phlegm-heat obstructing lung pattern;severe pneumonia;COVID-19;SARS-CoV-2;Meta-analysis
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发布时间：2022-08-31 - 摘要：Objective:To explore the relationship between the active components and targets of Xuebijing injection and coronavirus disease 2019 (COVID-19), and to provide theoretical basis for Xuebijing injection in the treatment of COVID-19 and new drug development. MethodsThe active compounds of Xuebijing injection and corresponding targets of each compounds were obtained from the TCMSP database and published researches, and the network was constructed and analyzed by Cytoscape. GO and KEGG analyses were performed on the obtained targets by DAVID and STRING databases. Results:①=1\*GB3From the database and published researches, 22 compounds in Xuebijing injection were obtained, corresponding to 504 potential targets. ②Among them 70 proteins were intersected with targets co-expressed with angiotensin-converting enzyme 2 (ACE2), a receptor of the novel coronavirus, suggesting that Xuebijing injection may play a therapeutic role on COVID-19 through these 70 proteins. ③=3\*GB3These target proteins regulate a series of signaling pathways, such as HIF-1 signaling pathway and PI3K-Akt signaling pathway. Conclusion:Xuebijing injection reflected an overall regulation of multi-components and multi-targets of traditional Chinese medicine for the treatment of COVID-19. It may realize the anti-virus function by regulating the pathways related to the development of disease through 70 proteins that can interact with ACE2 to relieve inflammation and inhibit virus replication.关键词：COVID-19;SARS-CoV-2;Xuebijing injection;network pharmacology;angiotensin-converting enzyme 2 (ACE2);anti-virus;multi-targets;overall regulation
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发布时间：2022-08-31 - 摘要：Based on the theory of “yang stagnation and blood stasis”, the involvement of apoptosis and mitochondrial energy metabolism through the mTOR signaling pathway in the pathogenesis of sick sinus syndrome and the main mechanism of treating sick sinus syndrome with Tongyang Huoxue (activating yang to promote blood circulation) prescription are explained by taking Professor Liu Zhiming’s academic idea of treating sick sinus syndrome from the angle of “yang stagnation and blood stasis” as the entry point.关键词：sick sinus syndrome;yang stagnation and blood stasis;Tongyang Huoxue prescription;mitochondria;mTOR;Master of Chinese medicine;Liu Zhiming
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发布时间：2022-08-31 - 摘要：The mechanism of competitive endogenous RNA (ceRNA) regulation in the occurrence and development of hepatocellular carcinoma (HCC) was reviewed and the relationship between TCM treatment of HCC and the regulation of ceRNA was discussed. The regulation of ceRNA takes miRNA as the core. Under the action of miRNA response element (MRE), Mrna, pseudogene transcripts, lncRNA, circRNA and others competitively combine with miRNA to form a ceRNA regulatory network. The regulation pattern of ceRNA plays an important role in the occurrence, development, metastasis and invasion of tumors. The research on the mechanism of ceRNA regulating HCC can improve the accuracy of targeted prediction and effectively screen potential therapeutic targets and prognostic biomarkers while at present it is still at the exploratory stage. The regulation mechanism of ceRNA is also an important regulation method of TCM in the treatment of HCC. The intervention of active ingredients of traditional Chinese medicine has a very broad prospect in the field of tumor treatment, and the study of the anti-tumor mechanism of traditional Chinese medicine based on ceRNA regulation also provides new research directions for the diagnosis and treatment of tumor.关键词：competing endogenous RNA;target gene regulation;hepatocellular carcinoma;TCM intervention
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发布时间：2022-08-31 - 摘要：Objective:This study aims to further improve the clinical basis of insomnia diagnosis of Chinese medicine by analyzing the PSQI scale of patients with“spleen without storing idea” and “kidney without storing willing”. MethodsAccording to the above classification,84 patients were included in the “spleen without storing idea” group,and 81 patients were included in the “kidney without storing willing” group,and their PSQI scores were analyzed and assessed. Results:There were statistical differences in sleep onset time,sleep quality and sleep efficiency between the two groups(P<0.05).Besides,the scores of the “spleen without storing idea” group is higher than the scores of the “kidney without storing willing” group. There were no significant differences in sleep time,sleep disturbance and daytime dysfunction between the two groups(P>0.05). In the comparison of the scores of PSQI,there were also significant differences between the two groups(P<0.01). Conclusion:The scores of PSQI of the “spleen without storing idea” group are higher than the “kidney without storing willing” group,which indicates its sleep quality is worse than the“kidney without storing willing” group. The patients of the “spleen without storing idea” group are characterized by the extension of sleeping time,the decreasing of sleeping quality and efficiency,while the“kidney without storing willing” group are characterized by the decreasing of sleeping time and quality. Based on the analysis of the PSQI scale,the differences between“spleen without storing idea” group and“kidney without storing willing” group are proved. Patients of “spleen without storing idea” group are worse in sleep quality than patients of “kidney without Storing willing ”group.
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发布时间：2022-08-31 - 摘要：Based on the interpretation of research results of modern and traditional medicine on cervical spondylosis of cervical type in recent years, the pathological mechanism of anterior and posterior cervical muscle group strength imbalance was expounded from the aspects of modern acupotomology, myofascial chain theory, action pattern and kinematic chain theory, traditional meridian and tendon theory, etc. It is believed that “T-shape” acupotomology combined with pectoralis minor release can restore the balance of bowstring mechanical structure, adjust the tension balance of fascia system, help to correct the abnormal movement pattern of neck and shoulder, improve the flow of qi and blood, regulate tendons and relieve pain, thus improving the symptoms of cervical spondylosis of cervical type.关键词：cervical spondylosis of cervical type;acupotomology;T-shape;pectoralis minor;mechanism
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发布时间：2022-08-31 - 摘要：Combined application of ascending and descending natured Chinese medicine is one of the basic formula compatibility methods, i.e., opposite and complementary compatibility. According to the basic principle of the ascending and descending movement of qi, indications, and/or the requirements for formula compatibility, herbs with different characteristics of floating-ascending and descending-sinking are applied together to restore the normal ascending and descending of qi movement inside the human body and cure diseases. Combined application of both ascending and descending natured Chinese medicine is widely used in the clinic, not only for diseases with both ascending and descending disorders, but also for diseases with single ascending or descending disorders. More importantly, it is to remove the pathogenic heat by regulating the ascending and descending of qi rather than simply regulating the ascending and descending of qi.关键词：combined application of both ascending and descending natured Chinese medicine;opposite and complementary;compatibility thinking
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发布时间：2022-08-31 - 摘要：Objective:To observe the clinical effect of acupoint application of cinnamon powder combined with conventional western medicine on gastrointestinal dysfunction in patients with spleen yang deficiency sepsis. MethodsNinety patients with gastrointestinal dysfunction of spleen yang deficiency sepsis were randomly divided into treatment group and control group, 45 cases in each group. The control group was given conventional western medicine treatment, and the treatment group was given cinnamon powder acupoint application besides the treatment measures of the control group. The two groups were treated for 7 days continuously. The changes of gastrointestinal dysfunction score, bowel sound score, abdominal circumference, intra-abdominal pressure, mean gastric retention volume, acute gastrointestinal injury (AGI) grade, acute physiology function and APACHE II score, TCM syndrome score, laboratory correlation index [WBC and PCT] were observed and compared. The incidence of multiple organ dysfunction syndrome (MODS) and 28-day mortality were followed up. Results:①During the experiment, 1 case dropped out in the control group, 2 cases dropped out in the treatment group and 87 cases in total completed the experiment, including 44 cases in the control group and 43 cases in the treatment group. ②After treatment, the gastrointestinal dysfunction score, bowel sound score, abdominal circumference, intra-abdominal pressure and mean gastric retention volume of both groups decreased compared with those before treatment (P<0.05). After treatment, the gastrointestinal dysfunction score, bowel sound score, abdominal circumference, intra-abdominal pressure and mean gastric retention volume in the treatment group were lower than those in the control group (P<0.05). ③After treatment, there was improvement of the AGI grade in both groups (P<0.05); after treatment, the AGI grade of the treatment group was better than that of the control group (P<0.05). ④After treatment, the scores of Apache Ⅱ and TCM syndrome in the two groups both decreased (P<0.05); the scores of Apache Ⅱ and TCM syndrome in the treatment group were even lower than those in the control group (P<0.05). ⑤After treatment, the serum WBC and PCT levels of the two groups were both lower than before (P<0.05); after treatment, the serum WBC and PCT levels of the treatment group were lower than those of the control group (P<0.05). ⑥The incidence of MODS was 7.0% in the treatment group and 22.7% in the control group. The incidence of MODS in the treatment group was lower than that in the control group (P<0.05); The 28-day mortality in the treatment group and the control group were 18.6% and 25.0%, respectively, and the difference had no statistical significance (P>0.05). Conclusion:Compared with conventional western medicine therapy, cinnamon powder acupoint application combined with conventional western medicine therapy can improve the gastrointestinal function, alleviate the disease condition, control the inflammatory reaction and reduce the incidence of MODS for patients with spleen yang deficiency type sepsis.关键词：sepsis;gastrointestinal dysfunction;spleen yang deficiency;cinnamon powder;acupoint application;integrated traditional Chinese and Western medicine therapy;multiple organ dysfunction syndrome
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发布时间：2022-08-31 - 摘要：Objective:To investigate the effect mechanism Bushen Jiangzhi recipe on atherosclerosis (AS) in ApoE-/- mice by regulating PPARγ-LXRα-ABCA1 pathway. MethodsApoE-/- mice with high-fat diet were randomly divided into three groups: ApoE-/- mice + high-fat diet group (model group), ApoE-/- mice + high-fat diet + Bushen Jiangzhi recipe group (Bushen group), and ApoE-/- mice + high-fat diet + Atorvastatin group (statin group). Male C57BL/6 mice of the same age and strain were used as normal control group (normal group) fed with common diet with 25 mice in each group. Each group was given corresponding intervention for 12 weeks. HE and Oil Red O staining were performed to detect pathological morphology and lipid accumulation of mouse aortic sinus and liver tissues respectively, and Filipin staining was performed to detect free cholesterol in mouse aortic sinus. Serum lipid levels (TC, TG, LDL-C, HDL-C) in peripheral blood of mice were detected by ELISA; The expression of PPARγ, LXRα and ABCA1 in aorta and liver tissues of mice was analyzed by Western blot. Results:ApoE-/- mice fed with high-fat diet showed typical AS lesions, large area of AS plaque and red-stained lipid were seen in aortic sinus, and free cholesterol increased. Hepatocyte structure disorder and red-stained lipid accumulation can be seen in the liver tissue. The content of TC and LDL-C in serum increased while that of HDL-C decreased. The protein expression levels of PPARγ, LXRα and ABCA1 in aorta and liver tissues decreased. Compared with the model group, the area of AS plaque, red stained lipid and free cholesterol in aortic sinus of mice in Bushen group decreased. after intervention by Bushen Jiangzhi recipe. The structure of liver cells in liver tissue was mostly clearly visible, and red stained lipid reduced. The content of serum TC and LDL-C decreased. The protein expression levels of PPARγ, LXRα and ABCA1 in aorta and liver tissues were up-regulated after intervention by Bushen Jiangzhi recipe (P<0.05, P<0.01, P<0.001). Conclusion:Bushen Jiangzhi recipe may effectively intervene the treatment of AS by regulating PPARγ-LXRα-ABCA1 pathway.
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发布时间：2022-08-31 - 摘要：Objective:To observe the effect of Tangshenning (TSN) on renal pathology and podocyte apoptosis in diabetic nephropathy (DN) mice. MethodsThe DN model was established by using KK-Ay mice, and the successful modeling KK-Ay mice were randomly divided into model (DN) group, TSN group and valsartan(VST) group. In addition, the same number of C57BL/6J mice was selected as the normal control (NC) group. The mice in the TSN group were fed with TSN 20 g kg-1·d-1, VST group with VST 10 mg kg-1· d-1 and the normal control and DN groups with the same dose of distilled water. The duration of intragastric administration was 12 weeks. 24-hour urinary protein was detected at 0,4, 8 and 12 weeks after intragastric administration, and blood samples from the apical heart were taken to detect the levels of serum creatinine and urea nitrogen after 12 weeks. The pathological changes of kidneys were observed by HE, Masson and PAS staining. The expression of Caspase-3 protein in podocytes was detected by immunohistochemistry and RT-PCR, and the apoptosis of podocytes was observed by TUNEL staining. Results:① Compared with the NC group,24-hour urinary protein,serum creatinine and urea nitrogen in the DN group were significantly increased (P<0.05); compared with the DN group,24-hour urinary protein,serum creatinine and urea nitrogen in the TSN and VST groups were significantly decreased (P<0.05). ②Compared with the NC group, the glomerular mesangial cells in the DN group increased and the extracellular matrix proliferated; compared with the DN group, the glomerular mesangial cells decreased and the extracellular matrix proliferation decreased in the TSN group and VST group. ③Compared with the NC group, the expression of Caspase-3 protein and mRNA in podocytes in the DN group were significantly up-regulated (P<0.05), while the expression of Caspase-3 protein and mRNA of podocytes in the TSN and VST groups were significantly down-regulated.④ Compared with the NC group,the number of podocyte apoptosis was significantly increased in the DN group (P<0.05) and that in the TSN and VST groups was significantly decreased than that in the DN group (P<0.05). Conclusion:TSN can reduce proteinuria and improve renal function in mice with diabetic nephropathy, and its mechanism may be related to its improvement of renal pathology and reduction of podocyte apoptosis.关键词：TSN;diabetic nephropathy (DN);renal pathology;podocyte;apoptosis;mice
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发布时间：2022-08-31 - 摘要：Objective:To improve the quality standard of Erkeling syrup. MethodsBulbus Fritillariae Thunbergii was identified by TLC.The contents of ephedrine hydrochloride,amygdalin and baicalin were analyzed by HPLC on Kromasil C18 column (250 mm × 4.6 mm,5 μm) with the mobile phase of acetonitrile-0.1% phosphate by gradient elution.The flow rate was 1.0 mL/min and the detection wavelength was set at 210 nm for ephedrine hydrochloride and amygdalin,280 nm for baicalin. The column temperature was 30 ℃. RseultsTLC identification method of Bulbus Fritillaria thunbergii had strong specificity. The spots in TLC were clear, and the negative samples showed no interference. Ephedrine hydrochloride had a good linear relationship with peak area in the range of 1.050 to 10.500 mg/L (r=0.999 4), and the average recovery rate was 99.1%(RSD=1.50%, n=9). In the range of 5.220-52.20mg/L, amygdalin had a good linear relationship with peak area (r=0.999 0), and the average recovery rate was 98.6%(RSD=0.81%, n=9). Baicalin showed a good linear relationship with peak area in the range of 20.050-200.500 mg/L (r=0.999 5), with an average sample recovery of 98.4%(RSD=0.94%, n=9). Conclusion:The method is accurate and repeatable,and can be used as the quality control of Erkeling syrup.关键词：Erkeling syrup;ephedrine hydrochloride;amygdalin;baicalin;TLC;HPLC
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发布时间：2022-08-31 - 摘要：The pharmacological and clinical research progress of cocoon shell was reviewed. Cocoon shell is not only a natural biomaterial with excellent properties, but also can be used as medicine after processing. It has the effects of hemostasis, thirst-quenching, detoxification and sore treatment. According to the modern medical research, cocoon shell hydrolysate can improve immunity, reduce blood sugar, promote cell proliferation, protect liver, and have antibacterial effects. Clinically, cocoon shell has significant effects on the treatment of diabetes mellitus, nephrotic syndrome and diabetes insipidus of women, etc.关键词：cocoon shell;traditional Chinese medicine;pharmacology;review
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发布时间：2022-08-31 - 摘要：Based on the basic TCM pathogenesis of obnubilation due to stroke caused by such pathological factors as blood stasis, liver wind and turbid phlegm, the method of Xingnao Kaiqiao acupuncture was created by Professor Shi Xuemin, an academician of the Chinese academy of engineering and a Master of Chinese medicine. It is a principle of treatment and acupuncture method which is widely used in the treatment of stroke and its complications. For sleep disorder, depression, vascular dementia, dysphagia, constipation and hiccup after stroke, it is emphasized that on the basis of regulating spirit, disease differentiation and syndrome differentiation should be unified, acupoints should be arranged according to the condition of syndrome, and attention should be paid to the quantitative standard of manipulation at the same time. In addition to the causes of stroke, many complications are also closely related to the psychological emotion and social environment of patients after stroke. The method of Xingnao Kaiqio accupucture is used to treat diseases by regulating spirit from all aspects, which is also in line with the biological-psychological-social model of modern medicine. Post-stroke complications can occur in all stages of stroke and are affected by many factors. Therefore, it is necessary to further explore and study the timing, course of treatment, curative effect evaluation and mechanism of acupuncture intervention in this method.关键词：Xingnao Kaiqiao method;acupuncture;stroke;post-stroke complications;Shi Xuemin;review
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发布时间：2022-08-31
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