最新刊期
期 3 ， 2020
- 摘要：This article summarizes the inheritance of Dong’s pediatrics and then discusses the clinical experience of Dr. Dong Tingyao, Wang Xiafang and Wang Yonghong in the diagnosis and treatment of pediatric asthma in children. It is considered that each one has his/her own characteristics. Among them, Dong Tingyao advocates “treating diseases based on their pathogenesis”, Wang Xiafang focuses on strengthening the spleen, and Wang Yonghong advocates simultaneous treatment of the lung and kidney.关键词：pediatric asthma;Dong’s Pediatrics;Dong Tingyao;Wang Xiafang;Wang Yonghong
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发布时间：2022-08-31 - 摘要：Professor Li Yan’s experience in the treatment of idiopathic edema is summarized. Professor Li believes that liver depression and blood stasis are the common pathogenesis of idiopathic edema, and the location of the disease is in the liver. The core pathogenesis is the disorder of water metabolism and the malfunction of the liver to dredge and discharge. The liver governs the discharge of qi, dredges the qi of the whole body, and is closely related to the spleen and kidney. Therefore, the treatment of idiopathic edema is mainly to sooth the liver, promote blood circulation and remove blood stasis. In addition, it should be complemented by invigorating the spleen, replenishing qi and eliminating phlegm, regulating and tonifying the kidney yin and kidney yang. The representative formula is modified Sini powder and Danggui Shaoyao powder. Two cases are attached for exemplification.关键词：idiopathic edema;soothing the liver and removing blood stasis method;Sini Powder;Danggui Shaoyao Powder;clinical experience;Li Yan
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发布时间：2022-08-31 - 摘要：To summarize Professor Yang Wei’s clinical experience in treating high complex anal fistula. Professor Yang attaches great importance to syndrome differentiation, emphasizing the differentiation of degree of urgency and excess-deficiency pattern before the surgery. He proposes the loosing or cutting seton therapy in the surgery and the post-operative wound treatment and line-tightening timing are also valued. Professor Yang advocates the “sixteen character policy” as the diagnosis and treatment principle and outlines the unique pre-operative education concept as “three disadvantages, one risk and easy to recur”.关键词：high complex anal fistula;loosing or cutting seton;expert’s experience;Yang Wei
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发布时间：2022-08-31 - 摘要：According to the relevant clauses in the “nineteen items of pathogenesis ” of Huangdi Neijing,“all sudden muscular spasm and rigidity are ascribed to wind”, “all vertigo and shaking due to wind are ascribed to the liver”, “all spasms and neck rigidity are ascribed to dampness”, “all dampness syndromes with swelling and fullness are ascribed to the spleen”, “all thin,clear and watery discharges are ascribed to cold”, and “all cold with contraction is ascribed to the kidney”. This article analyzes the relationship between these clauses and the clinical symptoms of Parkinson’s disease. It is recognized that the pathogenesis theory of “liver wind, spleen dampness, and kidney cold” should be fully considered to improve the clinical efficacy of traditional Chinese medicine on Parkinson’s disease.关键词：Huangdi Neijing;nineteen items of pathogenesis;Parkinson’s disease;Chinese medicine treatment
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发布时间：2022-08-31 - 摘要：The Kan hexagram and Li hexagram in The Book of Changes match with water and fire in the five elements, and kidney and heart in the five viscera. In The Book of Changes, under the normal circumstances, the Kan hexagram and Li hexagram are complementary to each other, the Kan hexagram is up and the Li hexagram is down, the yin and yang are intercourse and the water and fire are harmonization. In traditional Chinese medicine, the fire in heart descends to warm kidney yang, and the water in kidney ascends to nourish heart yin. Therefore, the heart and kidney are interacted, and yin and yang are balanced. Professor Fu Deyu often treats the heart disease by harmonizing the heart and kidney according to the theory of “Kan zhong man, Li zhong xu”, meanwhile emphasizes the application of Chinese medical classical prescription, which obtains good effects. This article introduces the clinical experience of Professor Fu Deyu in treating the heart disease and two proven cases are presented.关键词：heart disease;“Kan zhong man, Li zhong xu”;disharmony between heart and kidney;famous doctor’s experience;Fu Deyu
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发布时间：2022-08-31 - 摘要：To interpret the differences and changes between the “TCM Diagnosis and Treatment Program for COVID-19 in Shanghai (Trial)” and the “Diagnosis and Treatment Program for COVID-19 (Trail, Fifth Edition)” issued by the National Health Commission. ①In the Shanghai program, the recovery period was listed separately, TCM intervention after the improvement of clinical symptoms of COVID-19 was emphasized, i.e., prevention in the period from initial recovery to complete recovery. ②According to the Shanghai program, TCM patterns in the clinical treatment period were adjusted, which were expressed as damp toxin stagnating the lung pattern, heat toxin blocking the lung pattern, and internal blocking causing collapse pattern; Based on the clinical characteristics of patients in Shanghai, the pathological factors of “heat” and “toxin” were highlighted. ③In the clinical treatment period, the prescription for damp toxin stagnating the lung pattern was modified based on pattern identification in the Shanghai program, i.e., “for patients with nausea and vomiting, add 3 g of Huanglian (coptis rhizoma) and 6 g of Suye (perillae folium)”, taking the effect of Suye Huanglian decoction. ④In the clinical treatment period, 9 g Jianghuang (curcuma longa) and 9 g Jiangcan (bombyx batryticatus) were added to the prescription for the heat toxin blocking the lung pattern to achieve the effect of Shengjiang powder. ⑤For the treatment of heat toxin blocking the lung pattern, Tanreqing injection was added to the Chinese patent medicine recommendation list as it met the core pathogenesis of “damp, heat and toxin” of COVID-19. ⑥In the recovery period, the pattern of dual deficiency of qi and yin was added due to the characteristics of tiredness, lack of tongue fluid, and virus carrying in respiratory tract and feces in patients after abatement of fever, and Shashen Maidong decoction was used as the main formula, supplemented by Zhuye Shigao decoction, Xiebai powder, Shengjiang powder and other prescriptions.关键词：COVID-19;TCM diagnosis and treatment program;Shanghai area;epidemic pathogens of heat toxin;prevention of reoccurrence after initial recovery;dual deficiency of qi and yin
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发布时间：2022-08-31 - 摘要：To discuss the etiology, pathogenesis, diagnosis and treatment of COVID-19 based on the theory of febrile diseases. The theory of febrile diseases, derived from the accumulation of TCM classical theories and developed through the practice of plague prevention and treatment, has a systematic discussion on the etiology, pathogenesis, pattern identification and treatment of exogenous febrile diseases including virulent ones. It also has played an active role in the prevention and treatment of novel infectious diseases in China in recent years. “Warm-febrile diseases” and “plague” are interlinked. Plagues are mainly caused by heat toxin and epidemic pathogens, manifested as heat pattern and yang pattern, and can be treated according to the disease stages differentiated by “Wei-Qi-Ying-Xue or “Sanjiao” pattern identification methods, or treated with the prescriptions from famous ancient doctors such as Wu Youke and Pang Anshi, etc. These theories related to causes, mechanism, patterns and treatment may be helpful for the TCM diagnosis and treatment of COVID-19. In addition, the lungs and large intestine form an exterior and interior relationship, and the gastrointestinal tract is also the place where SARS-CoV-2 invades or proliferates, it may be a way to reduce virus infection and lung inflammation in the body by adopting the TCM method of clearing heat and dredging the lower part to give pathogenic factors a way out from the bowels.关键词：COVID-19;theory of febrile diseases;epidemic pathogens of heat toxin;expelling pathogens to the exterior with pungent-cold herbs;clearing heat and dredging the lower part;way out for the evil;Dayuan decoction
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发布时间：2022-08-31 - 摘要：COVID-19 has broken out in Wuhan and spread rapidly to most provinces and cities in China since December 2019. It has caused serious damage to the lives of patients and Chinese society and economy. In order to prevent complications caused by long-term bed rest and lack of activity in patients with COVID-19, and to prevent the adverse effects on cardiopulmonary function and physical and mental state, as well as to promote the recovery of pulmonary function and improve the prognosis, the rehabilitation medical team from Shanghai University of Traditional Chinese Medicine, based on the existing COVID-19 related diagnosis and treatment program, and under the proposal and guidance of experts from Shanghai Public Health Clinical Centre who are responsible for the diagnosis and treatment of COVID-19 in the front line, put forward rehabilitation training guidance and suggestions for convalescent patients with mild and severe COVID-19. Patients with mild COVID-19 are recommended the health Qigong Yangfei exercise while patients with severe COVID-19 are recommended the bed rehabilitation training. It is hoped that this proposal will help the front line medical colleagues responsible for the diagnosis and treatment of COVID-19 in China so that they can give patients instructions according to their individual conditions and promote the early recovery of patients.关键词：COVID-19;integrated traditional Chinese and western medicine;rehabilitation training;functional recovery;Liuzijue;Baduanjin;Yijinjing
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发布时间：2022-08-31 - 摘要：Based on the databases of Chinese Clinical Trial Registration Center and the American Clinical Trial Registration Center, the data related to the clinical trial registration of coronavirus disease 2019 (COVID-19) was retrieved, and the registration units, research types and trial drugs were statistically analyzed to provide reference for the prevention and treatment of epidemic diseases with traditional Chinese medicine in the future.关键词：COVID-19;clinical trial;registration;medical information;literature analysis
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发布时间：2022-08-31 - 摘要：The etiology, pathogenesis, clinical characteristics and therapeutic methods and prescriptions of the COVID-19 were analyzed based on the diagnosis and treatment experience of nearly 100 patients with COVID-19 in Shanghai. According to the characteristics of the disease, combined with the characteristics of the climate and residents’ physique in Shanghai, it is believed that COVID-19 belong to the category of “damp pestilence” in Traditional Chinese Medicine (TCM). The cause of the disease is the invasion of damp toxin and epidemic pathogens. The location of the disease mainly lies in the lungs, diffusing to the peuro-diaphragm and triple energizers. The key of the pathogenesis is that the damp toxin and epidemic pathogens attack the lungs, pathogens stagnated in the lungs transform into heat, and damp toxin and stagnation of heat are tangled up to diffuse to the peuro-diaphragm and triple energizers, transforming into dryness and consuming fluid, exhausting qi and impairing yin. For patients who are critically diseased, pathogens may go deeper into the nutrient-blood phase and heat pathogen may enter the pericardium. The treatment should take the principle of “eliminating pathogen” as the first priority, and the key treatment method is to disperse, drain and expel so as to give the pathogens of damp toxin a way out as soon as possible. At the early stage, it is necessary to resolve dampness and dispel turbidity, to diffuse and expel, and to disperse and drain. If the damp toxin stagnates and transforms into heat, clearing the stagnated heat should be considered as a complementary treatment method. If the damp toxin transforms into dryness and consumes body fluid, protecting fluid should be of great importance. At the middle stage, it is necessary to clear the lungs and purge the fire, diffuse the lungs and unblock the bowels, dredge the peuro-diaphragm and regulate the triple energizers, with the focus on dispelling damp toxin, clearing heat toxin and resolving stasis toxin, so as to stop the disease progress and protect yin and fluid in time. In the critical period, supportive treatment should be provided and formulas for opening obstruction and preventing desertion should be prescribed for severe cases. In the recovery period, attention should be paid to clear away residual pathogens, invigorate qi and nourish yin, as well as prevention and healthcare after initial recovery. TCM focuses on eliminating toxin and pathogens as early as possible (at the primary and middle stages) to stop the progress of COVID-19, improve the symptoms of patients, and facilitate the health care and recovery.关键词：COVID-19;damp pestilence;dispersing, draining and expelling;treatment by stages;truncating and reversing;prevention of reoccurrence after initial recovery
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发布时间：2022-08-31 - 摘要：Combined with 4 cases, the pathogenesis, pattern identification and treatment characteristics of COVID-19 in Gansu region were analyzed. Based on the analysis, it is believed that COVID-19 is caused by the invasion of damp-heat toxic pathogens. The disease is located in the lungs, affecting triple energizers. It is easy to spread and change, and the pathological changes are in line with the changes of climatic and regional conditions. At the early stage, pathogenic factors are in the phase of defense-qi, which should be dispersed, expelled, cleared and resolved. If the onset of the disease is on the menstrual period, it is essential to resolve dampness, expel pathogenic factors and relieve the exterior first, and harmonize Shaoyang to prevent heat from entering the blood chamber influencing both the defense phase and qi phase. If dampness stagnates in the lung and the defense phase, it is appropriate to dissipate cold and disperse dampness, clear heat and relieve sore throat. Jianpi Huashi Qingre decoction should be taken after initial recovery until residual pathogens are eliminated completely.关键词：COVID-19;Gansu;integrated traditional Chinese and Western medicine therapy;pattern identification and treatment;medical record
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发布时间：2022-08-31 - 摘要：Based on the characteristics and causes of yang deficiency physique,this article summarizes the clinical thoughts of Professor Wang Qi on the treatment of yang deficiency physique. Professor Wang Qi created a new model for diagnosis and treatment with the principle of “physique differentiation-disease differentiation-syndrome differentiation”. The principle of regulating yang deficiency physique is to nourish the kidney and warm the yang. In clinical practice, he masters the use of classic prescriptions, special medicines, and strong medicines in smart ways, and emphasizes the importance of objective evaluations.关键词：yang deficiency physique;treating by physique differentiation;famous doctor’s experience;Wang Qi;clinical thinking
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发布时间：2022-08-31 - 摘要：The Guideline on the Diagnosis and Treatment of Hepatic Fibrosis With Integrated Chinese and Western Medicine (2019 Edition) (new guideline) was issued by Professional Committee of Liver Disease of Chinese Society of Integrated Traditional Chinese and Western Medicine. It is a renewed edition of 2016 Edition (old guideline). The content is more closed to the clinical in the new guideline. There are 16 recommended suggestions with higher degree evidences in the new edition. In the new guideline, a section of pathological mechanism of hepatic fibrosis is added; the advantage of noninvasive diagnosis methodology in the section of diagnosis is confirmed; it is highlighted that the principle of therapy for the treatment of pathogen and for hepatic fibrosis is regarded both as equally important and several Chinese patent medicines and medicinal formulae are majorly recommended in the section of therapy; the main thinking which is in the research field of fibrosis is introduced about regression of hepatic fibrosis or liver cirrhosis in evaluation of therapeutic effect; the suggestion is added for treatment course, drug withdrawal and follow-up of anti-hepatic fibrosis; and finally four problems needed paing attention to and improved are presented.关键词：hepatic fibrosis;liver cirrhosis;unscrambling of guideline;integrated Chinese and western medicine;diagnosis and treatment
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发布时间：2022-08-31 - 摘要：By introducing a one case of reabsorption after L5-S1 giant disc herniation, this paper briefly discusses the clinical diagnosis and staged treatment of lumbar disc herniation. It is considered that the study of reabsorption of protruding nucleus pulposus should be paid attention to. In the clinical diagnosis and treatment of lumbar disc herniation, we should combine inquiry, palpation, observation and imaging data together to fully evaluate the disease of patients to determine the etiology and pathology, and strictly grasp the best indication of conservative treatment and surgical treatment.关键词：lumbar intervertebral disc herniation;reabsorption;medical record;conservative treatment
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发布时间：2022-08-31 - 摘要：To investigate the “way out for the evil” method recorded in the Treatise on Cold-Induced Diseases by analyzing the methods of diaphoresis, vomiting and purgation, etc. As a way to expel pathogenic evils, the “way out for the evil” method can drive the visible or invisible evil out of human body from the exterior, interior, anterior, posterior and collaterals. Once the pathogenic evil is expelled, the healthy qi can be preserved. One case is exemplified.关键词：Treatise on Cold-Induced Diseases;way out for the evil;expel evils;treating method
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发布时间：2022-08-31 - 摘要：This paper discusses effects and characteristics of Red Halloysite when used by doctors to treating various diseases in Han-Tang dynasties, through surveying and synthesizing existing TCM literatures. Red Halloysite was used to cure diarrhea as it promotes astriction and stemming desertion. It was used to treat feng diseases due to its effect of heavy tranquillization and tonifying marrow. It was also used to treat menstruation and leukorrhea diseases due to its effect of tonifying marrow and removing blood stasis. In the meantime, it was used to nourishing the body for its effect on replenishing marrow and essence.Furthermore, it also had the functions of replenishing heart-qi, resolving phlegm, and promoting tissue regeneration and healing of wounds.关键词：Red Halloysite;Han-Tang dynasties;efficacy;characteristics
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发布时间：2022-08-31 - 摘要：Objective:To observe the clinical effect of berberine hydrochloride tablets combined with metformin in the treatment of primary type 2 diabetes. MethodsA total of 192 patients with primary type 2 diabetes were randomly divided into treatment group and control group, 96 cases in each group; the control group was treated with metformin, and the treatment group was treated with berberine hydrochloride tablets and metformin. The course of treatment in both groups was 6 months. The changes of blood glucose (FBG, 2 hPPG, HbA1c), blood lipid (TC, LDL-C), BMI, oxidative stress products (8-OHdG, MDA, SOD), and immune cytokines (TNF-α, IL-6) were observed and the correlation between HbA1c and oxidative stress products (8-OHdG, MDA, SOD), immune cytokines (TNF-α, IL-6) was analyzed. Results:After treatment, the levels of FBG, 2 hPPG, HbA1c, TC, LDL-C, BMI, 8-OHdG, MDA, TNF-α, IL-6 significantly decreased (P<0.05) and the level of SOD significantly increased (P<0.05) in both groups; after treatment, all indexes in the treatment group improved more significantly than those in the control group (P<0.05), and 8-OHdG was positively correlated with HbA1c. Conclusion:Berberine hydrochloride tablets combined with metformin can effectively reduce the blood glucose, blood lipid, body mass, oxidative stress and inflammatory response in patients with primary type 2 diabetes, and 8-OHdG may be an evaluation index for the prognosis of type 2 diabetes mellitus.关键词：primary type 2 diabetes mellitus;berberine hydrochloride tablets;berberine;oxidative stress;immune cytokine;clinical study
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发布时间：2022-08-31 - 摘要：Objective:To evaluate the effect of “Yindai Daoqi” tuina massage on kinematics parameter in spastic children with cerebral palsy. MethodsA total of 36 children with spastic cerebral palsy were randomly divided into the experimental group and the control group with 18 cases each. The experimental group adopted the manipulation on the belt vessel and the Yangming channel on the lateral side of the thigh and received “Yindai Daoqi” tuina massage to induce the heel pedaling movement. The control group received the passive massage manipulation and kinesitherapy. The treatment time of both groups was 40 minutes each time, 5 times a week, and the course of treatment was 3 months. MAS, GMFM and 3DGA were assessed before and after treatment. Results:①Compared before and after treatment, both groups showed significant difference in the scores of GMFM-88 in walking, running and jumping (e-energy area) (P<0.05); after treatment, there was significant difference between two groups in the scores of GMFM-88 in walking, running and jumping (e-energy area) (P<0.05). ②Compared before and after treatment, both groups showed significant differences in gait kinematic parameters (P<0.05); after treatment, there were significant differences between two groups in the step length, knee extension (support phase), knee flexion (swing phase), hip external rotation and abduction, popliteal angle and ankle dorsiflexion during knee extension (P<0.05). Conclusion:“Yindai Daoqi” tuina massage has an advantage on the walking function improvement in children with spastic type cerebral palsy as it can facilitate the lower limb joint alignment and improve the walking efficiency.关键词：cerebral palsy;tuina massage;Yindai Daoqi;three-dimensional gait analysis (3DGA)
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发布时间：2022-08-31 - 摘要：Objective:To observe the combined effect of Jianpi Wenshen Ruanjian Jiedu formula, Kang’ai injection and low-dose chemotherapy on tumor focus, immune function and progression free survival (PFS) in elderly patients with advanced non-small cell lung cancer (NSCLC) of spleen kidney deficiency type. MethodsEighty elderly patients with advanced NSCLC of spleen kidney deficiency type were randomly divided into treatment group and control group, 40 cases in each group. The control group was given conventional dose chemotherapy, the treatment group was given Jianpi Wenshen Ruanjian Jiedu formula, Kangai injection combined with low-dose chemotherapy. After two cycles of chemotherapy, the tumor foci and immune function of the two groups were observed, and the PFS of patients were followed up. Results:①During the experiment, 2 cases in the control group dropped out and 78 cases completed the experiment, including 40 cases in the treatment group and 38 cases in the control group. ②After the second chemotherapy, there was no statistical difference in the composition of tumor focus evaluation between the two groups (P>0.05). ③Both groups showed no significant difference in the serum levels of NK, CD3 +, CD4 +, CD8 +after one cycle of chemotherapy compared with those before chemotherapy (P>0.05); the level of CD8 + in the treatment group increased (P<0.05) while the level of NK, CD3+, CD4 + in the control group decreased (P<0.05) after two cycles of chemotherapy. After one cycle of chemotherapy, the levels of CD3 + and CD4 + in the treatment group were higher than those in the control group (P<0.05); after two cycles of chemotherapy, the levels of NK, CD3+ and CD4+ in the treatment group were higher than those in the control group (P<0.05). ④ The median PFS of the two groups was 4.5 months and the difference was not statistically significant(P>0.05). Conclusion:Combined use of Jianpi Wenshen Ruanjian Jiedu formula, Kang’ai injection and low-dose chemotherapy can effectively control the changes of tumor foci in the elderly patients with lung and kidney deficiency type of NSCLC, stabilize the levels of serum NK, CD3+ and CD4 + and protect the immune function of the patients.关键词：non-small cell lung cancer;advanced stage;old age;low dose chemotherapy;integrated traditional Chinese and Western medicine therapy;immunity;tumor focus
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发布时间：2022-08-31 - 摘要：Objective:To observe the effect of electroacupuncture combined with auricular acupressure on sleep quality and life quality of perimenopausal women with insomnia. MethodA total of 60 participants were randomly divided into the treatment group and the control group, with 30 participants in each group. Patients in the control group were prescribed Estazolam tablets while patients in the treatment group were treated with electroacupuncture combined with auricular acupressure. The treatment course was 28 days in both groups. The clinical efficacy was observed. The changes of Pittsburgh sleep quality index (PSQI) score and perimenopausal life quality inventory (MENQOL) score were compared. Safety was evaluated. Results:①The overall effective rate was 93.3% in the treatment group and 73.3% in the control group; and the clinical efficacy in the treatment group was superior to that in the control group (P<0.05). ②The PSQI total score and sub-scores decreased compared to those before treatment in the treatment group (P<0.05), and PSQI total score, sleep time sub-score, sleep duration time sub-score, sleep efficiency sub-score decreased compared to those before treatment in the control group (P<0.05). After treatment, PSQI total score, sleep quality sub-score, sleep disturbance sub-score and daytime function sub-score of the treatment group were significantly lower than those of the control group (P<0.05). ③MENQOL score decreased significantly in both groups after treatment compared to that before treatment (P<0.05), and MENQOL score of the treatment group was lower than that of the control group after treatment (P<0.05). ④There was no obvious adverse reaction in both groups. Conclusion:Electroacupuncture combined with auricular acupressure achieved satisfactory results in the treatment of perimenopausal insomnia. It is worthy of clinical promotion and application as it can effectively improve the sleep quality and life quality with good safety.关键词：perimenopausal insomnia;electroacupuncture;auricular acupressure;Estazolam;PSQI;MENQOL
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发布时间：2022-08-31 - 摘要：Objective:To explore the therapeutic effect of GnRHa combined with Bushen Huayu Decoction coloclysis and Yigeng Decoction orally in treating patients with endometriosis (EMT) after laparoscopic surgery. MethodsNinety patients with EMT after laparoscopic surgery were enrolled and randomly divided into four groups, including 22 cases in GnRHa group, 20 cases in GnRHa + coloclysis group, 26 cases in GnRHa + Yigeng Decoction group, and 22 cases in GnRHa + Chinese medicine double therapy group, according to hierarchical method. The patients in the GnRHa group were given subcutaneous injection of enantone, the patients in the GnRHa + coloclysis group were given subcutaneous injection of enantone combined with Bushen Huayu Decoction coloclysis, the patients in the GnRHa + Yigeng Decoction group were given subcutaneous injection of enantone combined with Yigeng Decoction orally, and the patients in the GnRHa + Chinese medicine double therapy group were given subcutaneous injection of enantone combined with Bushen Huayu Decoction coloclysis and Yigeng Decoction orally. Twenty-eight days were a treatment course and all the patients were treated for 3 courses. Follow-up for 1 year after treatment, the dysmenorrhea scores and Chinese medical syndrome scores of all the groups were compared before surgery, 6 months and 1 year after treatment after surgery; the levels of serum cancer antigen (CA) 125, follicle stimulating hormone (FSH) and estradiol (E2) were detected, and the improvement of postmenopausal symptoms were evaluated by modified Kupperman score (K score) before surgery and after treatment after surgery. Results:①Six months and 1 year after treatment, the Chinese medical syndrome scores of all groups were obviously decreased compared with before surgery (P<0.05); 1 year after treatment, the Chinese medical syndrome score of the GnRHa group was significantly increased compared with 6 months after treatment (P<0.05). Six months and 1 year after treatment, the Chinese medical syndrome scores of the GnRHa + Chinese medicine double therapy group and GnRHa + coloclysis group were lower than those of the GnRHa group and GnRHa + Yigeng Decoction group (P<0.05). ②Six months and 1 year after treatment, the dysmenorrhea scores of all groups were obviously decreased compared with before surgery (P<0.05); 1 year after treatment, the dysmenorrhea scores of all groups were increased compared with 6 months after treatment (P<0.05). Six months and 1 year after treatment, the dysmenorrhea scores of the GnRHa + Chinese medicine double therapy group and GnRHa + coloclysis group were lower than those of the GnRHa group and GnRHa + Yigeng Decoction group (P<0.05). ③After treatment, the levels of FSH, E2 and CA125 of all the groups were obviously decreased compared with before surgery (P<0.05). After treatment, there were no sigificant statistical differences on the level of FSH among all the groups (P>0.05); the levels of E2 in the GnRHa group and GnRHa + coloclysis group were lower than those in the GnRHa + Yigeng Decoction group and GnRHa + Chinese medicine double therapy group (P<0.05); the levels of CA125 in the GnRHa + Chinese medicine double therapy group and GnRHa + coloclysis group were lower than those in the GnRHa group and GnRHa + Yigeng Decoction group (P<0.05). ④After treatment, the K scores of all the groups were obviously increased (P<0.05), and the K scores of the GnRHa group and GnRHa + coloclysis group were higher than those of the GnRHa + Yigeng Decoction group and GnRHa + Chinese medicine double therapy group (P<0.05). Conclusion:All the four therapeutic regimens can improve the Chinese medical syndrome and dysmenorrhea symptom, and decrease the level of CA125 in patients with EMT; GnRHa combined with Bushen Huayu Decoction coloclysis can better improve the Chinese medical syndrome and dysmenorrhea scores, and GnRHa combined with Yigeng Decoction orally can better improve the postmenopausal symptoms which were induced by the use of GnRHa; GnRHa combined with Bushen Huayu Decoction coloclysis and Yigeng Decoction orally can better improve the clinical symptoms of EMT, and relieve the postmenopausal symptoms, which is worthy popularization and application in clinic.关键词：endometriosis;after laparoscopic surgery;Bushen Huayu decoction;Yigeng Decoction;GnRHa
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发布时间：2022-08-31 - 摘要：Objective:To observe the clinical effect of fire acupuncture on common warts. MethodsRandomly divide 160 cases of common wart patientsA total of 160 cases of common wart patients were randomly divded into the treatment group and the control group, with 80 cases in each group. The control group was treated by local injection of myocellular cellspoly-myocyte in wart body, while the treatment group was treated by fire acupuncture. The treatment course was 28 days, and the clinical efficacy was observed. The changes of VAS pain score during treatment and the self-designed comprehensive grading score for common warts were compared, and the safety was also evaluated. Results:①In the process of the experiment, 3 cases in the fire acupuncturetreatment group and 6 cases in the poly myocytecontrol group dropped out, and 151 cases were collected including 77 cases in the fire acupuncturetreatment group and 74 cases in the poly myocytecontrol group.②The total effective rate of the fire acupuncturetreatment group was 97.4%, and that of Poly I-Cthe control group was 73.0%. Compared with the two groups, the fire acupuncturetreatment group showed better clinical effects than the Poly I-Ccontrol group (P<0.05). ③Compared before the second treatment, before the third treatment and before the first treatment respectively, both groups had no significant difference in the self-designed grading score for common warts (P>0.05). Compared before the fourth treatment and before the first treatment, both groups showed significant differences in the self-designed grading score for common warts (P<0.05). Compared before the second treatment and before the third treatment, both groups showed no significant difference in the self-designed grading score for common warts (P>0.05). Comparison between groups before the fourth treatment showed that the self-designed grading score for common warts in the fire acupuncturetreatment group was lower than that in the Poly I-Ccontrol group (P<0.05).④There was no statistically significant difference in VAS pain score between the groups at the first treatment (P>0.05). The VAS pain score in the fire acupuncturetreatment group was lower than that in the myocellularcontrol group at the second, third and fourth treatment respectively (P<0.05). ⑤No obvious adverse reactions were observed in either group during the experiment. Conclusion:The curative effect of fire acupuncture on common warts is satisfactory. Compared with Poly I-C injection therapy, it can better improve the clinical symptoms of patients with reduced pain and good safety, which is worthy of further clinical promotion and application.关键词：common wart;fire acupuncture;poly I-C injection
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发布时间：2022-08-31 - 摘要：Objective:To observe the effect of Shengxian Wumei decoction(SXWMD)on airway remodeling and TGF-β1/Smad signaling pathway in asthmatic rat model treated with glucocorticoids. MethodsTotally 50 SD male rats were randomly divided into normal group,asthma group,glucocorticoids intervened group,budesonide group and SXWMD group. The asthma model was established by sensitization and atomization stimulation with ovalbumin(OVA). Except rats in the normal group and asthma group,all of the others were intraperitoneally injected with glucocorticoids. Based on the glucocorticoids intervention,rats in the budesonide group were administered with budesonide by atomization,and rats in the SXWMD group were treated with intragastric administration of SXWMD. Lung function indexes and pathological changes of bronchus were measured. The expression levels of TGF-β1/Smad signaling pathway related indexes were detected by Western blot and RT-qPCR. Results:①Compared with the normal group, the levels of collagen,WAi/Pbm,WAm/Pbm and WAe/Pbm,the protein and mRNA levels of TGF-β1,Smad2 and Smad3,and the protein levels of p-Smad2 and p-Smad3 were significantly increased(P<0.05), while the levels of FEV0.1,FEV0.1/FVC%,FEF50% and FEF75%,the Ai/Pbm, and the protein and mRNA levels of Smad6 and Smad7 were significantly decreased(P<0.05)in the asthma group. ② Compared with the asthma group,the levels of WAi/Pbm,WAm/Pbm and WAe/Pbm,the mRNA levels of TGF-β1,Smad2,and Smad3,and the protein levels of TGF-β1,Smad2,p-Smad2 and p-Smad3 were significantly decreased(P<0.05), while the levels of FEV0.1,FEV0.1/FVC,FEF50% and FEF75%,and the mRNA levels of Smad6 and Smad7 were significantly increased(P<0.05)in all intervened groups. In addition,in the SXWMD group, the levels of WAi/Pbm,WAm/Pbm and WAe/Pbm,the protein and mRNA levels of TGF-β1,Smad2,and Smad3,and the protein levels of p-Smad2 and p-Smad3 were further decreased than those in the glucocorticoids intervened group(P<0.05),while the levels of FEV0.1,FEV0.1/FVC and FEF75%,the protein and mRNA levels of Smad6,and the mRNA levels of Smad7 were further increased(P<0.05). Conclusion:On the basis of glucocorticoids intervention,SXWMD could further prevent the abnormal activation of TGF-β 1/Smad signal pathway, inhibit the development of airway remodeling and delay the decline of lung function.关键词：Shengxian Wumei decoction;asthma;TGF-β1/Smad signaling pathway;glucocorticoids intervention;airway remodeling;rats
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发布时间：2022-08-31 - 摘要：Objective:Based on the basic TCM theory of the lung and the large intestine being interior-exteriorly related,this experiment explores the effect of Chinese herbal medicine－Jianpi Guchang recipe(JPGCR)on improving intestinal immune barrier function,regulating the balance of intestinal Treg/th17 cells and inhibiting the invasion and metastasis of lung cancer in mice after chemotherapy by mediating intestinal flora. MethodsLewis lung cancer cells were subcutaneously inoculated into C57BL/6 male mice to establish lung cancer model mice. Then according to the random number table,eighteen successful modeling mice were divided into tumor bearing group, chemotherapy group and Chinese medicine group with 6 mice in each group. After modeling,intervention was carried out. Cisplatin(density-dependent phosphoprotein, DDP) solution(0.1 mg/d) was injected intraperitoneally for 3 days in the chemotherapy group and traditional Chinese medicine group,and same volume of saline was injected intraperitoneally for 3 days in the tumor-bearing group. From the first day,the traditional Chinese medicine group was given JPGCR 0.6 mL/d by gavage. The Tumor bearing group and chemotherapy group were given same volume of saline daily. Samples were taken from the 18 mice after 21 days of intervention. The body weight, tumor weight, number of lung metastases in the three groups of mice were taken. Intestinal flora of mice was measured by Illumina Genome Analyzer IIx,and the levels of Th17 and Treg cell-related transcription factor RORγt and Foxp3 in small intestinal lymphoid tissue of mice were analyzed by RT-PCR. Results:The general condition and body weight of mice in the JPGCR group were better than those of the chemotherapy group,and the difference was statistically significant(P<0.01). The anti-tumor rate and inhibition rate of lung metastasis of mice in the JPGCR group were better than those in the chemotherapy group(P<0.05). Compared with the chemotherapy group,the intestinal flora diversity index Chao1 and Shannon of mice in the JPGCR group were increased significantly(P<0.01). Compared with the chemotherapy group,the intestinal immune index FoxP3 and RORγt of mice in the JPGCR group were decreased significantly(P<0.05). Conclusion:JPGCR can inhibit the invasion and metastasis of lung cancer cells in mice by increasing the diversity of intestinal flora,improving intestinal flora,regulating the balance of Th17/Treg cells in intestine of lung cancer mice,maintaining the balance of intestinal immunity and improving the body immunity.关键词：lung cancer;intestinal flora;intestinal immunity;FoxP3/RORγt;Jianpi Guchang recipe;mice
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发布时间：2022-08-31 - 摘要：This paper reviews the latest research progress in the treatment of myocardial ischemia reperfusion injury(MIRI)by regulating micro ribonucleic acid(miRNA)as a target with traditional Chinese medicine monomer(ginsenoside 1, apigenin, salvianolic acid B, luteolin), compound prescription(Yiqi Huoxue compound, Tongxinluo)and acupuncture[electroacupuncture pretreatment, needling neiguan(PC6) point by electroacupuncture, needling neiguan(PC6) point in both sides by electroacupuncture in vivo and microcurrent pretreatment in vitro], which provides an entry point for traditional Chinese medicine treatment of myocardial ischemia reperfusion injury and related prognosis intervention.关键词：myocardial ischemia reperfusion injury;miRNA;traditional Chinese medicine therapy;review
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发布时间：2022-08-31
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