最新刊期
期 11 ， 2020
- 摘要：Professor GaoYanbin’s clinical experience in treating obesity-related glomerulopathy (ORG) based on collateral disease theory was introduced in this paper. According to Professor Gao’s theory, ORG, in the category of “collateral disease” in traditional Chinese medicine, has the nature of deficiency in root and excess in manifestation and should be treated based on syndrome differentiation and stage identification. Syndromes at the early stage (stasis and stagnation of kidney collaterals) include dampness abundance due to spleen deficiency syndrome, damp-heat accumulation syndrome, and liver depression and stomach heat syndrome. The treatment principle is mainly to eliminate pathogenic factors to dredge collaterals by adopting methods of invigorating spleen and eliminating dampness, resolving dampness and clearing heat, soothing liver and clearing heat.Syndromes at the middle stage (stasis and blockage of kidney collaterals) include lung and spleen qi deficiency with dampness accumulation syndrome, liver and kidney yin deficiency with downward flow of damp-heat syndrome. The treatment principle is to strengthen body resistance and eliminate pathogens by adopting methods of replenishing qi, resolving dampness and dredging collaterals, tonifying liver and kidney and clearing damp-heat.Syndromes at the late stage (kidney overstrain and exhaustion) include dual deficiency of qi and yin with accumulation of damp-heat and toxin syndrome, spleen and kidney yang deficiency with intermingled phlegm and blood stasis syndrome. The treatment principle is mainly to strengthen body resistance by adopting methods of invigorating qi and nourishing yin and simultaneously promoting diuresis and removing toxicity, warming and invigorating spleen and kidney and simultaneously eliminating phlegm, promoting blood circulation and dredging collaterals.关键词：obesity-related glomerulopathy;collateral disease;famous doctor’s experience;Gao Yanbin
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发布时间：2022-08-31 - 摘要：The mathematical logic of Chinese classical philosophy has experienced the evolution process of “one”“two”and “three”. Everything originated from“one”,that is monism. Everything is unified,and everything is in a lifetime；from one to two,there is yin and yang,that isbinary (dualism)；two begets three,things begin to be many,this is ternary (ternism),“three” means the diversity of the universe. Rooting deeply in the soil of Chinese classical philosophy,ternary mode is ultimately applied in the theoretical system of traditional Chinese medicine to interpret how life happens,human anatomy,physiology,the etiology and pathogenesis,theories of materiamedica,etc.Therefore,“ternary system” is the key to open the door of traditional Chinese medicine.关键词：traditional Chinese medicine;thinking mode;ternary system
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发布时间：2022-08-31 - 摘要：Objective:To explore the syndrome elements and medication rules of gastroesophageal reflux disease (GERD) based on data mining. MethodsDatabases of China National Knowledge Network (CNKI), VIP and WanFang Data were searched, and relevant literatures from January 2010 to January 2020 were included. Excel databases containing syndrome elements of disease location, disease nature and medication was established. SPSS 20.0 was used for frequency analysis of Chinese herbal medicines (CHMs), and SPSS Modeler 18.0 was used for relational network model analysis and cluster analysis of relevant data. Results:①A total of 204 literatures were included, involving 364 prescriptions of traditional Chinese medicine. ②Through frequency analysis, 7 syndrome elements of disease location and 14 syndrome elements of disease nature were screened out. Stomach, liver and spleen were the top three syndrome elements of disease location with the highest frequency, while qi stagnation, qi deficiency and fire were the top three syndrome elements of disease nature with the highest frequency. ③Among the included 364 proved prescriptions, 208 CHMs were involved. There are 26 CHMs whose usage frequency was more than 10% of the total usage frequency, namely Gancao (Glycyrrhiza Glabra), Banxia (Rhizoma Pinelliae), Huanglian (Rhizoma Coptidis), Chaihu (Radix Bupleuri), Fulin (Poria Cocos), Chenpi (Pericarpium Citri Reticulatae), Wuzhuyu (Fructus Evodiae), Haipiaoxiao (Endoconcha Sepiae), Baishao (Radix Paeoniae Alba), Baizhu (Rhizoma Atractylodis Macrocephalae), Zhike (Fructus Aurantii), Houpo (Cortex Magnoliae Officinalis), Xuanfuhua (Flos Inulae), Dangshen (Radix Codonopsis), Huangqin (Radix Scutellariae), Zhebeimu (Bulbus Fritillariae Thunbergii), Daizheshi (Ochra Haematitum), Xiangfu (Rhizoma Cyperi), Duanwalengzi (Concha Arcae Preparata), Zhishi (Fructus Aurantii Immaturus), Sharen (Fructus Amomi), Ganjiang (Rhizoma Zingiberis), Zhuru (Caulis Bambusae in Taeniam), Zhizi (Fructus Gardeniae), Yujin (Radix Curcumae) and Shengjiang (Zingiber officinale). ④The results of correlation analysis showed that CHMs groups with higher support were Huanglian (Rhizoma Coptidis)-Wuzhuyu (Fructus Evodiae)-Chaihu (Radix Bupleuri), Huanglian (Rhizoma Coptidis)-Wuzhuyu (Fructus Evodiae)-Haipiaoxiao (Endoconcha Sepiae), Huanglian (Rhizoma Coptidis)-Wuzhuyu (Fructus Evodiae)-Banxia (Rhizoma Pinelliae)-Gancao (Glycyrrhiza Glabra), and Chaihu (Radix Bupleuri)-Zhike (Fructus Aurantii)-Baishao (Radix Paeoniae Alba). Conclusion:With stomach as the disease location, GERD is also closely related to liver and spleen. Qi stagnation, Qi deficiency and fire are the main syndrome elements of disease nature. The pathogenesis of GERD is mixed with deficiency and excess, together with the intermingling of cold and heat. When it comes to the treatment, the main methods are soothing liver and purging heat, harmonizing stomach and lowering adverse qi, invigorating spleen and supplementing qi. Once the transportation and transformation function of the middle energizer is restored, the clear qi will ascend and the turbid qi will descend spontaneously.关键词：gastroesophageal reflux disease;syndrome element;medication rule;data mining
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发布时间：2022-08-31 - 摘要：To analyze and summarize the application of Chuanxiong (Rhizoma Chuanxiong) in Jingui Yaolue (Synopsis of the Golden Chamber). It is considered that although there are only 9 prescriptions containing Chuanxiong in the book, Zhang Zhongjing, the author of the book, used it not only for the treatment of wind diseases, but also for fatigue and the treatment of women’s diseases. Its characteristics are mainly using interception method for wind disease, activating yang to nourish yang method for consumptive disease, and introducing yang into yin method for women’s disease. And 3 proven cases are presented.关键词：Chuanxiong;Jingui Yaolue;wind disease;consumptive disease;women’s disease
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发布时间：2022-08-31 - 摘要：Objective:To evaluate the efficacy and safety of Longteng Tongluo Tincture combined with three-step analgesic ladder in the treatment of cancer pain. MethodsA total of 100 patients with cancer pain were randomly divided into treatment group and control group, with 50 cases in each group. Both groups were treated based on three-step analgesic ladder. The treatment group was also administered Longteng Tongluo Tincture for external use. The course of treatment in both groups was 8 days, and Numeric Rating Scale (NRS) score changes were observed to quantify pain and evaluate pain-relieving effect accordingly. The morphine equivalent daily consumption, the frequency of pain outbreaks and the onset time of analgesia were observed, and the safety was evaluated simultaneously. Results:①The total effective rate of pain relief in the treatment group was 65.85%, and the obvious effective rate was 31.70%, which were higher than 44.19% and 18.60% in the control group. In terms of overall pain-relieving effect, the treatment group performed better than the control group (P<0.05). ②The NRS scores of the two groups decreased after treatment compared with those before treatment (P<0.05), and the decrease range of NRS scores in the treatment group was greater than that in the control group (P<0.05). Further stratified comparison showed that NRS scores of patients with various pain degrees in both groups decreased after treatment (P<0.05). Besides, among patients with moderate pain, the difference of NRS scores compared before and after treatment in the treatment group was greater than that in the control group (P<0.05). ③There was no significant difference in morphine consumption on the first day and average morphine equivalent daily consumption between the two groups (P>0.05). Further stratification comparison showed that the average morphine equivalent daily consumption of patients with moderate pain in the treatment group was less than that in the control group (P<0.05). ④There was no significant difference between the two groups in the frequency of pain outbreaks, the mean analgesic onset time and the incidence of adverse reactions (P>0.05). Conclusion:In the treatment of cancer pain, Longteng Tongluo Tincture and opioid analgesics have synergistic effects. Thus, it is worthy of further promotion as it can reduce the daily average consumption of opioids with good safety, especially for patients with moderate cancer pain.关键词：cancer pain;three-step analgesic ladder;Longteng Tongluo Formula;tincture;external treatment of traditional Chinese medicine
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发布时间：2022-08-31 - 摘要：Objective:To observe the clinical effect of self-formulated Shugan Jianpi Huazhuo Decoction combined with conventional therapy on juvenile nonalcoholic fatty liver disease (NAFLD) of liver depression and spleen deficiency syndrome. MethodsThe clinical data of 81 adolescent NAFLD patients with liver depression and spleen deficiency syndrome diagnosed and treated in our hospital from April 2017 to April 2019 were retrospectively analyzed. According to the treatment methods, they were divided into treatment group(43 cases) and control group(38 cases). The treatment group was treated with self-formulated Shugan Jianpi Huazhuo Decoction combined with conventional therapy, while the control group was treated with conventional therapy alone. After 12 weeks of continuous treatment, the clinical efficacy of the two groups was evaluated. The index changes of serum lipid metabolism, liver function, adiponectin, insulin-like growth factor-1 (IGF-1) and ultrasound imaging score were comparatively analyzed, and treatment safety was assessed simultaneously. Results:①The total effective rates of the treatment group and the control group were 90.70% and 73.68% respectively, suggesting better clinical effects in the treatment group than that in the control group (P<0.05). ②After treatment, the levels of serum triglyceride (TG), total cholesterol (TC), low density lipoprotein cholesterol (LDL-C), alanine aminotransferase (ALT), aspartate aminotransferase (AST) and Gamma-Glutamyl Transpeptidase (GGT) decreased (P<0.05), while the levels of high density lipoprotein cholesterol (HDL-C), adiponectin and IGF-1 increased in both groups (P<0.05). After treatment, the levels of serum TG, TC, LDL-C, ALT, AST and GGT in the treatment group were lower than those in the control group (P<0.05), while the levels of adiponectin and IGF-1 were higher than those in the control group (P<0.05), and there was no significant difference in HDL-C level (P>0.05). ③After treatment, ultrasound imaging scores of fatty liver grades in both groups decreased (P<0.05), and the scores in treatment group were lower than those in the control group (P<0.05). ④There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05). Conclusion:Compared with conventional therapy alone, self-formulated Shugan Jianpi Huazhuo Decoction combined with conventional therapy can achieve satisfactory results in treating adolescents with NAFLD of liver depression and spleen deficiency syndrome as it can better regulate lipid metabolism, protect liver function, increase adiponectin and IGF-1 levels and improve ultrasound imaging results while having good safety.关键词：non-alcoholic fatty liver disease;adolescent;liver depression and spleen deficiency syndrome;Shugan Jianpi Huazhuo Decoction
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发布时间：2022-08-31 - 摘要：Objective:To explore the effect of acupuncture method of strengthing spleen and invigorating kidney on ovulation and endometrial receptivity of infertile patients with PCOS undergoing in vitro fertilization(IVF)-embryo transfer(ET). MethodsEighty-two infertile patients with PCOS who undergoing IVF-ET were selected and randomly divided into the control group(42 cases)and the treatment group(40 cases). All the patients were treated with western medicine antagonist ovulation regimen,and the patients in the treatment group were treated with the acupuncture method of strengthing spleen and invigorating kidney based on obove. The number of retrieved oocytes and oosperms and the rate of high-quality embryos were compared. The levels of luteinizing hormone(LH),estradiol(E2)and progesterone(P)on the day of human chorionic gonadotropin(HCG)injection were detected and compared. The endometrial thickness and blood flow were tested on the day of HCG injection. The dosage of gonadotropin(Gn)in the cycle,the number of fresh embryo transfer,the HCG positive rate and the clinical pregnancy rate were compared. Results:①There were no statistically significant differences on the number of retrieved oocytes and oosperms between the two groups(P>0.05). The rate of high-quality embryos in the treatment group was higher than that in the control group(P<0.05). ②The levels of E2 and P on the day of HCG injection in the treatment group were higher than those in the control group(P<0.05). ③There was no statistically significant difference on the endometrial thickness on the day of HCG injection between the two groups(P>0.05). The endometrial blood flow positive distribution in the treatment group was superior to the control group(P<0.05). ④In the course of treatment,the dosage of Gn in the treatment group was less than that in the control group(P<0.05). ⑤There were no statistically 〖JP+significant differences on the HCG positive rate and the clinical pregnancy rate between the two groups(P>0.05). Conclusion:The acupuncture method of strengthing spleen and invigorating kidney combined with western medicine antagonist ovulation regimen can improve the endometrial receptivity and sex hormone levels,enhance the high-quality embryos rate,and reduce the dosage of Gn in infertile patients with PCOS undergoing IVF-ET.关键词：infertility;polycystic ovarian syndrome;in vitro fertilization-embryo transfer;acupuncture;antagonist therapeutic regimen
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发布时间：2022-08-31 - 摘要：Objective:To observe the clinical effect of add Suoquan Pill combined with electroacupuncture on overactive bladder(OAB)in women.MethodsA total of 60 OAB women patients were randomly divided into two groups,30 cases in each group. The control group were treated with tolterodine,and the treatment group were treated with adding Suoquan Pill combined with electroacupuncture.The treatment course was 4 weeks.The frequency of daily urination and night urination,average urine output,adverse reactions were compared between the two groups. Results:①After treatment,the treatment group and the control group could effectively decrease the frequency of daily urination and night urination,and increase average urine output. But there was no statistical difference in the frequency of daily urination and night urination between the two groups(P>0.05),average urine output in the treatment group was significantly more than that in the control group(P<0.05).②The rate of adverse reaction in the treatment group was significantly lower than that in the control group(P<0.05). Conclusion:Adding Suoquan Pill combined with electroacupuncture was effectively improve OAB women patients clinical symptoms and reduce the rate of adverse reaction.关键词：overactive bladder;women;electroacupuncture;Suoquan Pill;clinic trial
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发布时间：2022-08-31 - 摘要：Objective:To explore the application value of Fuyuan Decoction combined with the concept of enhanced recovery after surgery (ERAS) in the perioperative period of retroperitoneal laparoscopic minimally invasive surgery. MethodsNinety patients undergoing retroperitoneal laparoscopic minimally invasive surgery were randomly divided into treatment group and control group with 45 cases each. Both groups underwent retroperitoneal laparoscopic minimally invasive surgery. The traditional perioperative management was given to the control group, and perioperative management based on the concept of ERAS combined with Fuyuan Decoction was given to the treatment group. Days that general diet was allowed after surgery, drainage tube indwelling duration, first exhaust time, first defecation time, postoperative hospital stay, and changes in level of C-reactive protein (CRP) and albumin (Alb) were compared between the two groups. Postoperative complications and adverse reactions were also observed. Results:①After treatment, days that general diet was allowed after surgery, drainage tube indwelling duration, first exhaust time, first defecation time, and postoperative hospital stay in the treatment group were significantly shorter compared with those in the control group and the difference was statistically significant (P<0.05). ②Comparing test results on the first day and the fourth day after surgery with test results before surgery, CRP levels of the two groups both increased (P<0.05) and Alb levels both decreased (P<0.05). Comparing test results on the fourth day after surgery with test results on the first day, CRP levels of the two groups both decreased (P<0.05) and Alb levels both increased (P<0.05). On the fourth day after surgery, CRP level of the treatment group was significantly lower than that of the control group (P<0.05) and Alb level of the treatment group was significantly higher than that of the control group (P<0.05). ③The postoperative complication rate of the treatment group was 4.44%, which was significantly lower than 8.89% in the control group (P<0.05). ④The incidence of adverse reactions in the treatment group and the control group were 6.67% and 13.33%, respectively. The incidence of adverse reactions in the treatment group was lower than that in the control group (P<0.05). Conclusion:Fuyuan Decoction combined with ERAS concept has good application value in perioperative period of retroperitoneal laparoscopic minimally invasive surgery, as it is helpful to control inflammatory reaction, improve body stress responses, promote gastrointestinal function recovery, and further accelerate postoperative rehabilitation.关键词：retroperitoneal surgery;laparoscopic surgery;perioperative period;enhanced recovery after surgery;Fuyuan Decoction
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发布时间：2022-08-31 - 摘要：Objective:To explore the effects of Qidongning Formula(QDF) on lung cancer cells proliferation by regulating autophagy. Methods①The effects of different concentrations of QDF on the survival rate of A549 and NCI-H460 were detected by CCK8 assay, and the effects on the clone formation ability of A549 and NCI-H460 by clone formation assay. The effects of QDF on the expression of autophagy-associated proteins LC3B and p62 in A549 and NCI-H460 cells were detected by Western blot method, and the effect of QDF on the expression of LC3B was detected by immunofluorescence. The survival rates and colony formation ability of A549 and NCI-H460 cells under the inhibition of autophagy were detected by CCK8 assay and clone formation assay.②The subcutaneous transplanted tumor of NCI-H460 in nude mice was used as a model to observe the inhibitory effect of QDF on the tumor, and the expression of autophagy-related proteins LC3B and p62 in each group was detected by Western blot method. Results: The experiment in vitro showed that QDF could inhibit the proliferation of A549 and NCI-H460 cells. Under the condition of autophagy inhibition, the ability decreased of QDF against A549 and NCI-H460 cells proliferation. Western blot results showed that QDF could up-regulate the expression of LC3B and down-regulate the expression of p62 in A549 and NCI-H460 cells. The immunofluorescence results showed that QDF could concentrate the dispersed LC3B in the form of speckled. Animal experiments showed that QDF could inhibit the growth of NCI-H460 subcutaneously transplanted tumor in nude mice, up-regulate the expression of LC3B and down-regulate the expression of p62. Conclusion:sQDF could suppress lung cancer cells proliferation by regulating autophagy.关键词：QDF;lung cancer;autophagy;suppress;proliferation;cancer cell
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发布时间：2022-08-31 - 摘要：Objective:To observe the protective effect of JianpiJiedu Formula(JPJDF)on 5-FU-induced intestinal mucositis in rats through inhibiting TLRs/NF-κB signaling pathway. MethodsSixty-six SD rats were randomly divided into blank group, model group, JPJDF-Low, JPJDF-Medium and JPJDF-High groups of(0.31 g/mL, 0.62 g/mL, 1.24 g/mL)and Bifico group with 10 rats in each group. All the rats except the rats in the blank group were injected intraperitoneallywith 5-FU (50 mg/kg) once a day for 5 consecutive days. Rats in Chinese medicine treatment groups were given low, middle and high dose of JPJDF(3.1 g/kg, 6.2 g/kg, 12.4 g/kg)respectively, once a day for 7days during the chemotherapy, while those inBifico group were given Bifico (151mg /kg)daily for 7days. Diarrhea and body weight of rats were recorded daily. Seven days later, HE staining was used to observe the structure of rat small intestine. Immunohistochemistry was used to detect the expression of Occludin protein in small intestine.The serum levels of TNF-α and IL-10 were measured by ELISA, and the expressions of MyD88, p65, and TLRs in the intestine were detected by Western blot. Results:①During the experiment, the weight of the rats in the blank group increased progressively. From the 3rd day, the weight of the rats in the model, JPJDF-Low, JPJDF-Medium, JPJDF-High and Bifico groups began to decrease. From the 5th day of the experiment, the rats in the JPJDF-High group had milder weight loss compared with those in the model group(P<0.05). Diarrhea occurred in all groups except the blank group from the 5th day, and reached the peak on the 6th day, and the incidence of diarrhea in the JPJDF-High group was lower than that in the model group on the 6th day (P<0.05).②The expression of Occludin protein in the model group decreased(P<0.01). Compared with the model group, the expression of Occludin protein in all dose groups of JPJDF increased, among which the JPJDF-High group increased most significantly(P<0.01).③The expression of serum TNF-α in the model group was higher than that in the blank group(P<0.05). Each treatment lowered its level and the TNF-α in the groups of JPJDF-Medium and JPJDF-High was lower than that in the JPJDF-Low group(P<0.05). IL-10 in the model group was lower than that in the normal group(P<0.05), and its level in the JPJDF-High group and Bifico group were higher than that in the model group(P<0.05). ④The expressions of MyD88, p65, TLR4 protein in model group was higher than those in the blank group(P<0.01), while the expressions in the JPJDF-Medium and JPJDF-High groups and Bifico group were lower than those in the model group, and theexpressions also decreased in the JPJDF-Medium and JPJDF-High groups compared with JPJDF-Low group. Conclusion:JPJDF can inhibit TLRs/NF-κB signaling pathway and regulate inflammatory related factors, finally alleviating the 5-FU-induced intestinal mucosal inflammation in rats.关键词：intestinal mucositis;rats;5-fluorouracil;JianpiJiedu Formula;signaling pathways
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发布时间：2022-08-31 - 摘要：Objective:To research the effect of Guanxinkang on the cholesterol level of HepG2 cells induced by ox-LDL at different concentrations,as well as the cholesterol metabolism-related miR-33a,miR-122 and LDLR. MethodsSerum containing Guanxinkang and simvastatin were prepared respectively,and HepG2 cells were randomly divided into blank control group,model group,simvastatin group and Guanxinkang group. HepG2 cells were induced by ox-LDL with concentrations of 20,40,80 and 160 mg/L respectively for 24 hours,and then incubated with serum containing drugs for 48 hours respectively. The cell morphology of HepG2 cholesterol metabolism model was observed by oil red O staining. The expression levels of mir-33a,mir-122 and LDLR genes were detected by real-time PCR,and the protein expression of LDLR was detected by Western blot. Results:Compared with the model group, Guanxinkang can significantly reduce the content of orange lipid droplets in HepG2 cells after ox-LDL induction at different concentrations,up-regulate the expression of LDLR gene and protein in the cells after ox-LDL induction,and inhibit the expression of miR-33a and miR-122 gene(P<0.05, P<0.01). Conclusion:Guanxinkang can up-regulate the expression of LDLR gene and protein,inhibit the expression of miR-33a and miR-122 gene,thereby reducing the content of cholesterol in cells and alleviating the process of cholesterol metabolism imbalance.关键词：Guanxinkang;cholesterol metabolism;LDLR;miR-33 a;miR-122;HepG2 cell;rats
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发布时间：2022-08-31 - 摘要：Objective:To compare the effects of triptolide-loaded glycerol-mediated ethosomes(TP-ES)and gel plaster on the rat adjuvant arthritis model. MethodsTP-ES was prepared by injection method,and its particle size distribution and encapsulation efficiency were measured.The cross-linked sodium polyacrylate was used as the carrier for preparing the TP-loaded gel plaster. Rat adjuvant arthritis model was established,and gel plaster was used as a control to evaluate the therapeutic effect of TP-ES on adjuvant arthritis. Results:The average particle size of the prepared TP-ES was 153.10±2.69 nm,the zeta potential was -45.73±0.60 mV,and the encapsulation efficiency was 75.97±0.94%. Under the transmission electron microscope,the phospholipid vesicles are nearly round with smooth surfaces and even distribution. After topical administration,compared with the positive group(tripterygium glycoside with intragastric administration),the TP-ES group had less effect on the body weight of the rats,indicating that the toxic and side effects were reduced. The rats arthritis index and toe volume, as well as the levels of TNF-α, IL-6 and IL-1β in the blood of TP-ES group, were significantly lower than those of the model group. Compared with the gel plaster group, the TP-ES group showed stronger inhibition of the expression of TNF-α and IL-6(P<0.05). Conclusion:By using glycerol-mediated ethosomes as the transdermal drug delivery carrier can effectively improve the transdermal delivery of drugs, thereby enhancing the therapeutic effect.关键词：rheumatoid arthritis;triptolide;liposomes;glycerol-mediated ethosomes;gel plaster;transdermal drug delivery system
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发布时间：2022-08-31 - 摘要：Objective:To investigate the chemical constitutes from the stems of Sargentodoxa cuneata. MethodsCompounds were extracted by the method of system solvent,and isolated and purified by a combination of various chromatographic techniques,including silica gel column,ODS column,and preparative HPLC methods.Their structures were elucidated on the basis of their physiochemical property and NMR spectra. Results:Ten compounds were obtained from 95% ethanol extract of the stems of Sargentodoxa cuneata and identified as staphylionoside D,4-hydroxy-1-(2-nitroethyl)benzene 4-O-(6′-O-β-D-xylopyranosyl)-β-D-glucopyranoside,vanillyl alcohol-4-O-β-D-glucopyranoside,3,4,5-trimethoxyphenyl-β-D-glucopyranoside,isotachioside,4-hydroxy-3,5-dimethoxy-phenol,dimethyl 2,3′-dimethoxyosoate,uridine,syringaldehyde and fomannoxin acid, respectively. Conclusion:All compounds are isolated from the genus Sargentodoxa for the first time.关键词：Sargentodoxa cuneata;staphylionoside D;4-hydroxy-1-(2-nitroethyl)benzene 4-O-(6′-O-β-D-xylopyranosyl)-β-D-glucopyranoside;vanillyl alcohol-4-O-β-D-glucopyranoside;chemical constituents
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发布时间：2022-08-31 - 摘要：Objective:To optimize the preparation process of Yugu Liaoshang Tablets and to select the optimal formulation. MethodsOn the basis of investigating the particle size of the extract, the dissolution amount of dipsacus asperosaponins in the tablets was used as the index, and the relationship among stirring speed, granulation speed and povidone K30 slurry concentration was further investigated by orthogonal test. The single factor was used to further optimize the lubricant and coating process conditions. Results:The best prescription for Yugu Liaoshang Tablets was the extract pellets mixed with 10% lactose, 7.5% sodium carboxymethyl starch and 2.5% povidone K30, and 0.5% magnesium stearate and pressed; the coating was done with a low ethanol concentration coating solution. Conclusion:The preparation process of Yugu Liaoshang Tablets is stable, and the moisture absorption of the tablets was improved after coating, which increased the stability of the product, and made it easier to store and transport.关键词：Yugu Liaoshang Recipe;tablet;prescription process
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发布时间：2022-08-31 - 摘要：Objective:To provide theoretical basis for explaining the effectiveness of Renshenbaidu San in interfering with coronavirus disease 2019(COVID-19)by screening the effective components and targets of Renshenbaidu San via network pharmacology and exploring the internal relationship between Renshenbaidu San and COVID-19. MethodsTCMSP was used to find and screen the effective components and their corresponding targets of Renshenbaidu San. Cytoscape 3.7.2 was used to construct and analyze its network.DAVID and STRING databases were used to carry out enrichment analysis and PPI network construction. The effective components of the top 3 in degree value were molecular docking with angiotensin converting enzyme 2(ACE2). Results:Through search and analysis,191 effective components of Renshenbaidu San were obtained,302 targets with repetitive information were eliminated,75 targets with intersection with COVID-19,439 GO analysis items,and 122 corresponding signal pathways in KEGG pathway enrichment analysis.Molecular docking results showed that quercetin,luteolin and kaempferol could all bind ACE2 effectively. Conclusion:Renshenbaidu San has the advantages of multi-component and multi-target in interfering with COVID-19. The effective components and potential mechanism of Renshenbaidu San in interfering with COVID-19 are explored through network pharmacology method,which provide theoretical basis for further revealing its potential mechanism.关键词：COVID-19;Renshenbaidu San;network pharmacology;molecular docking
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发布时间：2022-08-31 - 摘要：To summarize the research progress of paeoniflorin(PF)in neuroprotection in the past decade. Paeoniflorin has a wide range of pharmacological effects in the nervous system,mainly including anti-oxidation of nerve cells(such as reducing the level of oxygen free radicals,regulating the content of nitric oxide and inducible nitric oxide synthase,and activating adenosine A1 receptors),preventing mitochondrial damage,regulating MAPK,PI3K/Akt,Nrf2/ARE signal transduction pathway,preventing calcium influx,regulating autophagy,inhibiting neuroinflammation,etc.关键词：paeoniflorin;neuroprotection;oxidative stress;apoptosis;autophagy;inflammatory factor;review
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发布时间：2022-08-31 - 摘要：Effect of STAT signaling pathway on bronchial asthma and the research progress of traditional Chinese medicine intervention were reviewed.STAT1 can activate intercellular adhesion molecules,and increase airway inflammation；The dimer formed by activated STAT2 and phosphorylated STAT1 can affect the differentiation of helper T lymphocyte 2 (Th2) cells,induce the secretion of immunoglobulin E (IgE) and inflammatory cell infiltration,leading to asthma；STAT3 can induce the immune response of interleukin-6 (IL-6),promote the differentiation of helper T lymphocyte 17 (Th17),and cause the inflammatory response；Phosphorylated STAT4 can induce the expression of corresponding transcription factors of regulatory T cells (Treg)and antagonize the differentiation of Th17 cells；Activated STAT5 can induce the differentiation and proliferation of eosinophils (EOS),inhibit EOS apoptosis,and increase EOS production during the attack of asthma；STAT6 can participate in the occurrence and development of asthma by influencing the immune response of Th2 cells.Traditional Chinese medicine can alleviate asthma symptoms,airway inflammation and airway remodeling by regulating Janus kinase / signal transduction and activator of transcription (JAK / STAT)related signal pathway.关键词：STAT;bronchial asthma;traditional Chinese medicine;review
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- 476
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发布时间：2022-08-31 - 摘要：Based on the academic thought of ‘tendon governing bone and treating tendon for bone disease’by professor Zhan Hongsheng,this article elaborates that tendon governing bone is the foundation of maintaining the harmony between tendons and bones, and holds that the disharmony of tendons and bones is the cause of non-specific low back pain, and treating tendon for bone disease is a strategy for preventing and controlling the disease. It also emphasizes the rationality, importance and clinical significance of the treatment of non-specific low back pain from tendon aspect.关键词：chronic lesions;non-specific low back pain;tendon governing bone;treatment from tendon aspect;experience of famous doctors;Zhan Hongsheng
- 6
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- 330
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发布时间：2022-08-31 - 摘要：Combined with four cases, this paper introduces professor Li Qizhong’s experience in treating epigastric pain with combined Sini Powder. Professor Li believes that epigastric pain is usually caused by the liver and the stomach. First of all, he pays attention to soothing liver and harmonizing stomach with combined Sini Powder. As appropriate, Sini Powder with Sijunzi Soup is strengthening spleen and invigorating qi,with Huangqi Jianzhong Soup is strengthening spleen and stomach,with Fuzi Lizhong Soup is warming middle energizer to stop diarrhea,with Banxia Xiexin Soup is mildly regulating cold and heat. Other small compounds such as Zuojin Pill,Jinglingzi Powder,Liangfu Pill and Erchen Soup are added or reduced based on syndrome differentiation.关键词：Sini Powder;compound combination;epigastric;famous doctor’s experience;Li Qizhong
- 8
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- 213
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发布时间：2022-08-31 - 摘要：From three aspects of “blood should be activated instead of stopped”“liver should be tonified instead of attacked”and“qi should be cut down rather than dropped fire”,the application of Miao Xiyong’s three methods of blood-stanching in the treatment of renal hematuria was analyzed. The course of renal hematuria was usually long,therefore pathogenic factors would enter the collateral. Activating blood circulation and removing blood stasis should be applied in the whole treatment process. Activating blood drugs were easily damage yin and blood,so they were often compatible with the drugs of soft liver and nourishing blood. Renal hematuria often mixed with damp heat and wind heat,which obstructed the kidney collaterals,so a little upraised and divergent drugs could restore the whole body qi and remove the pathogenic factors.关键词：srenal hematuria;three methods of blood-stanching;Miao Xiyong
- 5
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- 271
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发布时间：2022-08-31
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