最新刊期

    7 2019
    • ZENG Simin,LIANG Qi,WEI Jing,LUO Pengji,HUANG Guihua,LIN Huasheng
      Vol. 53, Issue 7, Pages: 18-20(2019) DOI: 10.16305/j.1007-1334.2019.07.005
      摘要:This paper introduces Professor Huang Guihua’s clinical experience in treating glucocorticoid adverse reactions from the point of view of traditional Chinese medicine (TCM). The characteristics of glucocorticoid are analyzed from TCM, and the pathogenesis of adverse reactions is expounded. It is considered that glucocorticoids have the nature of yang-heat, easy to consume kidney essence, and easy to make phlegm, dampness and stagnant heat, imbalance of water and fire, dysfunction of the spleen. For those with phlegm accumulating with stagnation, the treatment should be focused on dispelling phlegm and blood stasis; for those with imbalance of water and fire, attention should be paid to regulating yin and yang in the kidney; for those with the dysfunction of the spleen and stomach, it is appropriate to take care of the middle energizer(zhongjiao); for those with the deficiency of kidney essence, it should be based on tonifying the kidney.  
      关键词:glucocorticoid;adverse reactions;Chinese medicine treatment;clinical experience;Huang Guihua   
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      发布时间:2022-08-31
    • CAI Shanshan,LIANG Huiqing,YANG Jiaen,WU Yaonan
      Vol. 53, Issue 7, Pages: 21-23(2019) DOI: 10.16305/j.1007-1334.2019.07.006
      摘要:This paper introduces Professor Wu Yaonan’s clinical experience in treating chronic liver disease from the perspective of “membrane source”. Professor Wu believes that disease caused by latent evil in the membrane source has the same pathogenic characteristics with chronic liver disease; the liver is located in the middle jiao and is a part of the digestive system, which is similar to the location of disease in membrane source, so “Dayuan Drink” and the method of “clearing the membrane source” can be used to treat chronic liver disease from the perspective of “membrane source”. And two proven cases are given for discussion.  
      关键词:chronic liver disease;membrane source;latent evil;Dayuan Drink;experience of famous physicians;Wu yaonan   
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    • ZHOU Hua,YAN Xiaotong,WANG Longhui,CHEN Jingjing,CHEN Danping
      Vol. 53, Issue 7, Pages: 24-28(2019) DOI: 10.16305/j.1007-1334.2019.07.007
      摘要:This paper introduces the clinical experience of Professor Chen Danping in the treatment of infertile women with diminished ovarian reserve(DOR)by using the method of nourishing the kidney, assisting pregnancy and adjusting the cycle of menstruation. Professor Chen Danping considers that kidney deficiency is the root of the disease, blood stasis is an important link, and the dysfunction of the heart, liver and spleen is the common factor. In the treatment of the disease, he adopts the method of nourishing the kidney, assisting pregnancy and adjusting the cycle of menstruation to improve the ovarian reserve. At the same time, Professor Chen Danping focuses on promoting blood circulation to remove blood stasis and regulating Zang-fu organs. He is good at using flesh and blood products to fill the extraordinary meridians. He pays attention particularly to the determination of patients’ basic body temperature and the time of sexual intercourse for impregnation and calms the fetus in time after pregnancy.  
      关键词:infertility;diminished ovarian reserve;nourishing the kidney and adjusting the cycle of menstruation;clinical experience;Chen Danping   
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    • XU Hao,ZHONG Shenglan,ZHANG Wei,LI Jiaqin,LIANG Linjiang
      Vol. 53, Issue 7, Pages: 29-30(2019) DOI: 10.16305/j.1007-1334.2019.07.008
      关键词:circular mixed hemorrhoids;segmental separation of milligan-morgan hemorrhoidectomy;experience of famous doctor;Liang Linjiang   
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    • XU Jing,ZHOU Yongming,BAO Jizhang
      Vol. 53, Issue 7, Pages: 1-5(2019) DOI: 10.16305/j.1007-1334.2019.07.001
      摘要:This paper introduces the clinical experience of Professor Zhou Yongming in the treatment of chronic deficiency disease with plaster prescription. He thinks that deficiency disease is caused by deficiency, and the deficiency of qi,blood,yin and yang is the important pathological factors. The deficiency disease involves five zang-organs,and the liver,spleen and kidney are the key points in the treatment. The plaster prescription, which has the action of nourishing slowly and regulating the bias of yin and yang, is effective in the treatment of deficiency disease.  
      关键词:deficiency disease;plaster prescription;experience of famous doctor;Zhou Yongming   
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    • CAI Din
      Vol. 53, Issue 7, Pages: 6-9(2019) DOI: 10.16305/j.1007-1334.2019.07.002
      关键词:Jiang Chunhua;biography;disease differentiation combined with syndrome differentiation;therapy of cutting off and reversing the disease process   
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    • ZHU Leilei,LI Li,GU Zhijian,GENG Qi,CUI Chen,ZHOU Dan,JIANG Jian
      Vol. 53, Issue 7, Pages: 10-14(2019) DOI: 10.16305/j.1007-1334.2019.07.003
      摘要:Objective:To summarize and analyze the patterns of prescriptions and medicines for oral administration and enema in the treatment of ulcerative colitis (UC) with traditional Chinese medicine (TCM) by data mining and literature research. MethodsClinical research literatures on the treatment of UC with Chinese medicine published in the last 10 years were retrieved in databases including CNKI, Wanfang Data and VIP. A literature research database was established, a statistical analysis was performed on the effect category and frequency of the herbs and prescriptions discussed in the literatures, and data mining analysis of association rules and network diagram was carried out on core prescriptions and herbs.  Results:①A total of 339 relevant articles were included:50 prescriptions were for oral administration, the most commonly used was Wumei Pill, and the association rules also showed a strong association of “Wumei-Fuzi-Huanglian”; 167 Chinese herbs were used commonly, 31.11% of them were tonifying herbs and 20.15% were heat-clearing herbs; 26 Chinese herbs were used with a frequency over 10%, such as Gancao, Huanglian, Baizhu, Baishao, Dangshen, Danggui, Muxiang, Fuling, Huangqin, Huangqi, Baitouweng, Chenpi, Wumei, etc., and the association rules showed a strong association of herbs invigorating the spleen and tonifying qi. ②16 prescriptions were used for enema and the most commonly used was Baitouweng Decoction, and the association rules also showed a strong association of “Baitouweng-Qinpi-Huangbai-Huanglian”; 123 Chinese herbs were used commonly, 39.17% of them were heat-clearing herbs, 17.72% were hemostatic herbs, and 17 Chinese herbs were used with a frequency over 10%, such as Huanglian, Baiji, Huangbai, Diyu, Baitouweng, Huangqin, Kushen, Baijiangcao, etc. The network diagram showed a strong association of “Baitouweng-Huanglian-Huangbai-Baiji-Diyu”. 5 Chinese patent medicines were used, and Xilei Powder was the most commonly used. ③Huanglian had a strong association with the other drugs in association rules and network diagram of both oral administration and enema.  Conclusion:Oral administration of Chinese medicines to treat UC is mainly focused on reinforcement of healthy qi by invigorating spleen and replenishing qi, and elimination of pathogenic factors by clearing heat and drying dampness, with the most commonly used prescription being Wumei Pill; in treatment by enema, it is mainly focused on clearing heat, removing toxins, drying dampness, stanching bleeding, resolving putridity and promoting granulation, with the most commonly used prescriptions being Baitouweng Decoction and Xilei Powder. Overall, the most commonly used herb is Huanglian both for oral administration and enema.  
      关键词:ulcerative colitis;oral administration of Chinese medicines;enema with Chinese medicines;patterns of prescriptions and medicines;literature study   
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      发布时间:2022-08-31
    • GAO Ling,WANG Dongbin,GUO Cheng,SHI Zhijun,GAO Xiyan
      Vol. 53, Issue 7, Pages: 15-17(2019) DOI: 10.16305/j.1007-1334.2019.07.004
      摘要:This paper introduces a new one-piece neck-shoulder moxibustion apparatus, which effectively eliminates the inconvenience and problems caused by applying moxibustion treatment on the neck and shoulder simultaneously. ①The new moxibustion apparatus is composed of a casing and a protective mesh. The casing has a hollow structure with an opening on the bottom, and has a movable cover plate on the top. ②When applying moxibustion, it can be placed on the treatment bed steadily without the support of the patient’s body. ③The casing has a partition board inside, which can effectively separate the casing to form a neck moxibustion compartment and a shoulder moxibustion compartment. ④It can work with needling. Compared with warm needling, this moxibustion apparatus has a protective mesh, so that the ash will not fall off and cause burns to the patient directly. ⑤The smoke is concentrated in the casing, and the moxibustion temperature is stable, with less smoke and pollution. The new moxibustion apparatus has a structure that is novel and unique, simple and reasonable. It has the characteristics of easy production, low cost, convenient operation, high moxibustion efficiency and less pollution.  
      关键词:one-piece neck-shoulder moxibustion apparatus;structure;function;moxibustion therapy;moxa stick   
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      发布时间:2022-08-31
    • CHEN Jie,LI Haifeng
      Vol. 53, Issue 7, Pages: 31-33(2019) DOI: 10.16305/j.1007-1334.2019.07.009
      摘要:In order to discuss the pathogenesis of deficiency and excess of heart qi in Neijing (Yellow Emperor’s Internal Cannon of Medicine), this paper points out that the deficiency and excess of heart qi in Neijing not only means the “excess of evil-qi and the deficiency of essence-qi”, but also can be explained by the local waxing and waning of essence and the accumulation of essence. Excess of heart qi refers to accumulation of heart qi, including excess of heart qi, accumulation of the Jingqi(essence qi)in the heart and superabundance of heart qi. Deficiency of heart qi refers to the insufficiency of essence or the weakening of function in the heart, including the deficiency of heart qi, decline of heart qi, slowness of heart qi, lack of heart qi and endopenia of heart qi.  
      关键词:Neijing;heart;heart qi;deficiency and excess   
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    • YANG Fushuang,CAO Fang,SU Xin
      Vol. 53, Issue 7, Pages: 34-36(2019) DOI: 10.16305/j.1007-1334.2019.07.010
      摘要:There are 23 prescriptions with white paeony root and Chinese yam used together to cure 8 groups of diseases in Records of Tradition Chinese and Western Medicine in Combination by Zhang Xichun. White paeony root and Chinese yam together have interdependence between ascending and descending, and adjust yin and yang to stop convulsions, which can cure consumptive diseases and cholera; this two herbs, with one divergent and the other astringent combined together, as well as storage and excretion together, stop asthma and diarrhea, which can cure dyspnea syndrome and diarrhea;this two herbs treat deficiency and excess, cause and symptoms simultaneously to stop bleeding and regulate menstruation, which can cure vomiting and bleeding, amenorrhea and aberratio mensium; this two herbs nourish and purge simultaneously and replenish water and fall the fire at the same time to treat dysentery and stop urination pain, which can cure painful urination and dysentery. Zhang Xichun’s treatment based on syndrome differentiation and his rule of prescription are analyzed based on the theory and his 23 prescriptions to guide the clinical practice.  
      关键词:Zhang Xichun;Records of Tradition Chinese and Western Medicine in Combination;couplet medicines;compatibility;academic thoughts   
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    • OUYANG Wei,DONG Yujuan,ZHU Yaling
      Vol. 53, Issue 7, Pages: 37-43(2019) DOI: 10.16305/j.1007-1334.2019.07.011
      摘要:Objective:To systematically evaluate the clinical efficacy of Sofren Injection combined with conventional therapy in treatment of heart failure. MethodA computer-based search of Chinese and English databases was conducted on December 2018 to collect literatures on clinical randomized controlled trials (RCTs) with Sofren Injection in the treatment of heart failure. Quality evaluation was performed on the literatures included according to Cochrane Handbook for Systematic Reviews of Interventions. Using RevMan 5.3 and Stata 12.0, the clinical efficacy of Sofren Injection in the treatment of heart failure was analyzed by meta-analysis.  Results:Totally 15 RCTs with 1,9 patients were included. The results of meta-analysis showed that compared with conventional therapy, Sofren Injection combined with conventional therapy had better comprehensive efficacy in treating heart failure [OR=3.59,5% CI (2.45,5.26), P<0.000 01], increased the left ventricular ejection fraction (LVEF) [SMD=1.10,5% CI (0.98, 1.23), P<0.000 01], improved the left ventricular end-diastolic diameter [SMD=-0.9,5% CI (-1.32, -0.48), P<0.000 01], reduced the levels of plasma brain natriuretic peptide (BNP) (SMD=-1.43,5% CI (-2.19, -0.68), P<0.000 01) and N-terminal B-type BNP precursor (SMD=-4.89, 95% CI (-7.50, -2.29), P<0.000 01), and increased the walking distance in 6-minute walking test [MD=29.26,5% CI (20.90,7.61), P<0.000 01].  Conclusion:The efficacy of Sofren Injection combined with conventional therapy is superior to that of conventional therapy alone in treatment of heart failure. However, the quality and quantity of the literatures included in the analysis are limited, and the conclusion needs to be verified with follow-up studies.  
      关键词:Sofren Injection;heart failure;clinical efficacy;Meta-analysis   
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    • WANG Yixi,CEN Jie,XU Bing
      Vol. 53, Issue 7, Pages: 44-47(2019) DOI: 10.16305/j.1007-1334.2019.07.012
      摘要:Objective:To evaluate the clinical efficacy of Qiyu Qinghua Decoction on proteinuria in chronic kidney disease (CKD) of the spleen and kidney qi deficiency type and its effect on inflammatory cytokines. Methods72 patients with proteinuria in CKD of the spleen and kidney qi deficiency type were randomly assigned into treatment group and control group, 36 patients in each group. Conventional therapy in Western medicine was given in both groups, in addition, the treatment group was treated with Qiyu Qinghua Decoction, and the control group received Shenyan Kangfu Tablets. Both groups were treated for 6 months. The clinical efficacy and the changes in the scores of syndromes in traditional Chinese medicine (TCM), 24-hour urinary protein quantification (UPro), renal function, serum albumin, blood lipids as well as inflammatory cytokines (hs-CRP, TNF-α and IL-6) were observed.  Results:①=1\*GB3The total effective rate was 77.8% and 52.8% in the treatment group and the control group, respectively, and the clinical efficacy in the treatment group was superior to that in the control group (P<0.05). ②After treatment, the scores of edema, poor appetite and abdominal distention and the total score of TCM syndrome decreased in both groups (P<0.05), and the scores of lumbar spine ache and fatigue also decreased in the treatment group (P<0.05). The scores of lumbar spine ache and fatigue and the total score of TCM syndrome were significantly lower in the treatment group than in the control group after treatment (P<0.05). ③=3\*GB3After treatment, the 24h UPro decreased significantly in both groups (P<0.05); the 24h UPro,Scr and eGFR improved in the treatment group compared to the control group (P<0.05). ④=4\*GB3After treatment, the levels of hs-CRP, TNF-α and IL-6 decreased in both groups (P<0.05); and the levels were lower in the treatment group than in the control group (P<0.05).  Conclusion:Qiyu Qinghua Decoction shows improved clinical efficacy in treating proteinuria in CKD of the spleen and kidney qi deficiency type, improves clinical symptoms of the patients, reduces the excretion of urinary protein and delays the deterioration of renal function. It is possible that the drug protects the kidney by reducing the expression of inflammatory cytokines.  
      关键词:chronic kidney disease;Qiyu Qinghua Decoction;proteinuria;inflammatory cytokine;clinical efficacy   
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    • ZHANG Guohui,MOU Xin,GUO Qingjuan,QIU Fengxi,ZHANG Hong
      Vol. 53, Issue 7, Pages: 48-51(2019) DOI: 10.16305/j.1007-1334.2019.07.013
      摘要:Objective:To observe the clinical efficacy of core stability exercises combined with manipulation therapy in the treatment of lumbar disc herniation (LDH). Methods60 patients with LDH were randomly assigned into treatment group and control group, 30 patients in each group. Both groups received manipulation therapy, and the treatment group was treated with core stability exercises additionally. The treatment course was 20 days. The changes in the visual analogue score (VAS) of pain, Oswestry disability index (ODI), and values of peak torque (PT) of the abdominal flexors and the extensors of lumbar and dorsal region were compared.  Results:①After treatment, the VAS score and ODI decreased in both groups compared to those before treatment (P<0.05); and they were lower in the treatment group than in the control group (P<0.05). ②After treatment, the PT values of the abdominal flexors and the extensors of lumbar and dorsal region increased in both groups compared to those before treatment (P<0.05), with no statistically significant differences between the groups (P<0.05).  Conclusion:Core stability exercises combined with manipulation therapy shows satisfactory effects in treating LDH, is more effective in relieving pain, and improves activities of daily living of patients compared to manipulation therapy alone.  
      关键词:lumbar disc herniation;core stability exercises;manipulation therapy;isokinetic muscle strength;peak torque   
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    • ZHENG Zhenli,GAO Yuqing,HAN Ning
      Vol. 53, Issue 7, Pages: 52-55(2019) DOI: 10.16305/j.1007-1334.2019.07.014
      摘要:Objective:To observe the clinical efficacy of Guizhi Fuling Pills combined with levonorgestrel intrauterine system (IUS) in the treatment of uterine adenomyosis and the effects on the levels of vascular endothelial growth factor (VEGF) and carbohydrate antigen 125 (CA125) in serum. MethodsA total of 108 patients with uterine adenomyosis were randomly assigned into treatment group and control group, 54 patients in each group. The control group was given levonorgestrel IUS, and the treatment group was treated with Guizhi Fuling Pills and levonorgestrel IUS. The course of treatment was 6 months. The clinical efficacy and safety were observed. The changes in endometrial thickness, uterine volume, dysmenorrhea score, menstrual volume score, serum sex hormone index [luteinizing hormone (LH), follicle stimulating hormone (FSH) and estradiol (E2) ] and the levels of VEGF and CA125 were compared.  Results:①The total effective rate was 90.74% and 75.93% in the treatment group and the control group, respectively. The clinical efficacy in the treatment group was significantly superior to that in the control group (P<0.05). ②After treatment, the endometrial thickness, uterine volume, dysmenorrhea score and menstrual volume score were significantly lower in the treatment group than in the control group (P<0.05). ③After treatment, the levels of LH, FSH, VEGF and CA125 were significantly lower in the treatment group than in the control group (P<0.05), while the E2 level was significantly higher than in the control group (P<0.05). ④The incidence of adverse reactions were 14.81% and 11.11% in the treatment group and the control group, respectively, with no significant difference between the groups (P<0.05).  Conclusion:In the treatment of uterine adenomyosis, Guizhi Fuling Pills combined with levonorgestrel IUS can more effectively improve the symptoms of dysmenorrhea and menorrhagia, reduce the uterine volume and endometrial thickness, and lower the levels of serum VEGF and CA125, resulting in better overall efficacy without increasing adverse reactions.  
        
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    • TAN Lingjie,ZHANG Liqiong,XU Shuyu,LU Shiting,QIU Yan,LU Hao
      Vol. 53, Issue 7, Pages: 56-59(2019) DOI: 10.16305/j.1007-1334.2019.07.015
      摘要:Objective:To observe the effects of Xiaoying Mixture on thyroid autoantibodies in early Hashimoto thyroiditis (HT) in women of child-bearing potential. MethodsA randomized, double-blind, parallel-group, placebo-controlled study was conducted, in which 64 women with HT who met the inclusion criteria were assigned into treatment group and control group, 32 patients in each group. The treatment group was treated with Xiaoying Mixture and the control group was given placebo. The treatment course was 12 weeks in both groups. Titers of thyroid peroxidase antibody (TPOAb) and thyroglobulin antibody (TGAb) and levels of sex hormones including follicle stimulating hormone (FSH), luteinizing hormone (LH), estradiol (E2), progesterone (P), testosterone (T) and prolactin (PRL) were measured before and after treatment. Menstruation and pregnancy were recorded in both groups.  Results:After treatment, the level of TPOAb in the treatment group was significantly lower than that before treatment (P<0.05), and there was statistically significant difference between the groups (P>0.05). Before and after treatment, there was no significant difference in the levels of TGAb, FSH, LH, E2, P, T or PRL between the groups (P>0.05). Before and after treatment, there was no significant difference in abnormal menstruation between the groups (P>0.05). During the trial, there was no new pregnancy or adverse pregnancy outcomes in either group.  Conclusion:Xiaoying Mixture reduces the titer of thyroid autoantibodies in HT in women of child-bearing potential, but there are no significant positive results in menstruation and adverse pregnancy outcomes.  
      关键词:Xiaoying Mixture;Hashimoto thyroiditis;thyroid autoantibody;thyroid peroxidase antibody;women;child-bearing potential   
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    • WANG Ting,WANG Qiaolin,DUAN Chunyan,HE Nana,ZHOU Lihong,SUI Hua,DENG Wanli
      Vol. 53, Issue 7, Pages: 60-65(2019) DOI: 10.16305/j.1007-1334.2019.07.016
      摘要:Objective:To observe the effects of Yiqi Fusheng Recipe (YQFS) combined with chemotherapy on tumor infiltrating lymphocytes in the tumor microenvironment, and to explore the mechanism of action of YQFS combined with chemotherapy on tumor growth in tumor-bearing mice with gastric cancer. MethodsThe MFC gastric cancer cells were inoculated to mice under the armpit, and the tumor bearing model of mice was established. The mice were divided into five groups, namely blank control group, model group, 5-FU + low-dose YQFS group, 5-FU + high-dose YQFS group and 5-FU group. The blank control group was not treated, the model group was given 0.9% NaCl solution by gastric gavage, the 5-FU + low-dose and 5-FU+ high-dose YQFS groups were given 5-FU intraperitoneal injection for 7 days and different doses of YQFS by gastric gavage for 21 days, and the 5-FU group was given 5-FU intraperitoneal injection for 7 days. Materials were taken after 21 days, the tumor tissue and spleen of tumor-bearing mice with MFC gastric cancer were weighed to calculate the tumor inhibition rate and the spleen index. The levels and proportions of CD4 and CD8 subsets in tumor infiltrating lymphocytes were detected by flow cytometry. The changes in expression of IFN-γ, TNF-α, IL-10 and IL-6 in peripheral blood were detected by ELISA. Pathological changes of gastric mucosa in mice were observed by HE staining of tissue sections.  Results:The inhibition rate of YQFS combined with chemotherapy was 54.46% in tumor-bearing mice with gastric cancer, significantly different from that of chemotherapy alone. YQFS combined with chemotherapy could change the shape of gastric mucosa and reduce spleen index, which decreased with increase in YQFS concentration in a dose-dependent manner (P<0.05). Compared with the model group, YQFS combined with chemotherapy could increase the ratio of CD4+/CD8+ in tumor infiltrating lymphocytes and the proportion of CD4+; it could also increase the expression of INF-γ in peripheral blood of tumor-bearing mice with gastric cancer, and reduce the expression of IL-10, IL-6 and TNF-α, showing dose-dependent changes with the concentration of YQFS.  Conclusion:The anti-tumor effects of YQFS combined with chemotherapy may be related to increase of the CD4+/CD8+ ratio in tumor infiltrating lymphocytes, decrease in spleen index, up-regulation of INF-γ and down-regulation of IL-10, IL-6 and TNF-α in peripheral blood, recovery of tumor immunization homeostasis and improvement of immunity in tumor-bearing mice with gastric cancer.  
      关键词:Yiqi Fusheng Recipe;gastric cancer;tumor infiltrating cells;immunity;CD4;+;/CD8   
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    • SHI Yi,CHEN Wei,MENG Lingpeng
      Vol. 53, Issue 7, Pages: 66-69(2019) DOI: 10.16305/j.1007-1334.2019.07.017
      摘要:Objective:To explore the effects of Radix et Rhizoma Rhei and Radix Salviae Miltiorrhizae on the levels of inflammatory factors in serum of septic rats by miRNA-155. MethodsWistar rats were divided into normal control group, sepsis model group, Chinese medicine (Radix et Rhizoma Rhei and Radix Salviae Miltiorrhizae) group and miRNA-155 inhibitor group, 15 rats in each group. Except the normal group, sepsis model was established with rats in the other groups and drugs were given accordingly. At 3 hours after modelling, the levels of IL-6 and IL-10 in serum were detected, and the expression of miRNA-155 in serum was detected by RT-PCR.  Results:The expression of miRNA-155 and the levels of IL-6 and IL-10 were higher in the model group than in the normal control group (P<0.05). The expression of miRNA-155 and the levels of IL-6 and IL-10 were lower in the Chinese medicine group and the miRNA-155 inhibitor group than in the model group (P<0.05). There were no significant differences in the expression of miRNA-155 or the levels of IL-6 and IL-10 between the Chinese medicine group and the miRNA-155 inhibitor group (P>0.05).  Conclusion:Radix et Rhizoma Rhei and Radix Salviae Miltiorrhizae may reduce the levels of IL-6 and IL-10 in serum of septic rats through miRNA-155, thereby alleviating the inflammatory reactions of sepsis.  
      关键词:sepsis;rats;Radix et Rhizoma Rhei;Radix Salviae Miltiorrhizae;miRNA-155;inflammatory reactions   
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    • YIN Ying,GU Wei,LU Yuan
      Vol. 53, Issue 7, Pages: 70-74(2019) DOI: 10.16305/j.1007-1334.2019.07.018
      摘要:Objective:To investigate the effects of modified Qingying Decoction on the expression of TNF-α and IL-4 in dorsal skin of rats with acute eczema. MethodsSixty SD rats were randomly divided into 6 groups, 10 rats in each group:loratadine group, high-, middle-, and low-dose Qingying Decoction groups, model group and normal group. No modelling treatment was performed in the normal group. Rats in the other groups were modeled by applying 2,4-Dinitrochlorobenzene (DNCB) reagent on the right back of rats’ skin, and then modified Qingying Decoction, loratadine solution, and 0.9% NaCl solution were given to the successfully modelled rats by gastric gavage. After treatment, the severity of eczema in the experimental groups was evaluated by scoring. Skin weight was measured and compared after treatment. The content of TNF-α and IL-4 in skin tissue of the right back of rats was determined by immunohistochemistry (SP method).  Results:①Compared with the model group, the scores of severity of eczema were reduced significantly in the middle- and low-dose Qingying Decoction groups (P<0.05), especially in the high-dose group (P<0.01), suggesting that Qingying Decoction could significantly improve the symptoms of skin erosion, edema and erythema in rats caused by DNCB. ②Compared with the model group, the degree of swelling was reduced significantly in the loratadine group and the Qingying Decoction groups (P<0.01); it was reduced significantly in the middle- and high-dose Qingying Decoction groups compared with the low-dose group (P<0.05); it was reduced significantly in the high-dose Qingying Decoction group compared with the middle-dose group (P<0.05); it was reduced significantly in the high-dose Qingying Decoction group compared with the loratadine group (P<0.05). ③Compared with the model group, the content of TNF-α and IL-4 in the affected skin tissue decreased significantly in the loratadine group and the Qingying Decoction groups (P<0.01); it decreased significantly in the high-dose Qingying Decoction group compared with the loratadine group (P<0.05).  Conclusion:Modified Qingying Decoction can significantly improve the symptoms of local exudation, erosion, erythema and swelling in rats with acute eczema and it may exert the therapeutic effects by regulating the levels of TNF-α and IL-4.  
      关键词:acute eczema;rats;Qingying Decoction;TNF-α;IL-4   
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    • XING Lin,WANG Shuli,REN Weiming,WANG Yanmei,ZHAO Dan,LI Yueru
      Vol. 53, Issue 7, Pages: 75-82(2019) DOI: 10.16305/j.1007-1334.2019.07.019
      摘要:Objective:To establish the near infrared rapid nondestructive qualitative clustering model for rapid and nondestructive identification of Chidi ginseng, wild ginseng, transplantation of wild ginseng and Pahuo ginseng at the molecular level. MethodsNondestructive collection of samples was performed using a Fourier-transform near infrared spectrometer, with wavenumbers in the range of 10 000 cm-1~4 100 cm-1, and then the rapid and nondestructive qualitative clustering model of four samples was established with a chemometrics software.  Results:The identification rate of the established qualitative clustering model for the four types of samples was 98%, 98%, 97% and 97% respectively, and the overall identification rate of the verification spectra of the four types of samples was up to 98%. The scores of Chidi ginseng sample, wild ginseng sample, transplantation-of-wild-ginseng sample and Pahuo ginseng sample on the first principal component (PC1) were 0.089 724~0.125 83,0.098 37~0.127 75,0.045 894~0.186 13 and 0.084 432~0.131 41, respectively. On the secondly principal component (PC2), the scores were -0.290 4~0.168 99, -0.310 65~0.211 6, -0.165 8~0.117 87 and -0.200 84~0.160 3, respectively and the scores on the thirdly principal component (PC3) were -0.190 41~0.322 63, -0.255~0.201 1, -0.359 39~0.227 26 and -0.211 3~0.286 93, respectively.  Conclusion:The established near-infrared rapid and nondestructive qualitative clustering model is capable for qualitative detection of the 4 different kinds of ginseng and has certain application value.  
      关键词:nondestructive detection;Fourier-transform near infrared spectroscopy;chemometrics;different kinds of ginseng   
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    • LI Ji,LI Xiang,CAO Mingming,DONG Wanru,JIANG Jinqi
      Vol. 53, Issue 7, Pages: 83-87(2019) DOI: 10.16305/j.1007-1334.2019.07.020
      摘要:This paper summarizes the research progress in pharmacological actions of liquorice and the proportion of couplet medicines in combination. Modern pharmacological studies have shown that liquorice and its active components have the effects of anti-oxidation, anti-inflammation, regulating immunity, anti-ulcer, detoxification, anti-cancer and anti-hepatic fibrosis etc. Liquorice not only has therapeutic effects when used alone, but also has different effects when used in combination with different drugs, such as liquorice-platycodon root, liquorice-peony root, liquorice-cassia twig, liquorice-rhubarb and so on.  
      关键词:liquorice;pharmacological action;combination;review   
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    • CAI Yiqing,CHEN Yu,ZHANG Teng
      Vol. 53, Issue 7, Pages: 88-92(2019) DOI: 10.16305/j.1007-1334.2019.07.021
      摘要:This paper summarizes the major mechanisms underlying vascular remodeling and the interventional effects of traditional Chinese medicine in hypertension. Vascular remodeling is an important pathological link in damages to the target organs by hypertension. Abnormal hemodynamics, vasoactive substances, extracellular matrix, non-coding RNAs and other mechanisms can lead to vascular remodeling. Compound formulas of Chinese medicines (e.g., Qingxuan Jiangya Decoction and Simiao Yongan Decoction) and Chinese herbal extracts (e.g., vaccarin and puerarin) play a positive role in hypertensive vascular remodeling.  
      关键词:hypertension;vascular remodeling;therapy in traditional Chinese medicine;review   
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