最新刊期
期 6 ， 2019
- 摘要：This paper introduces Professor Su Li’s experience in the combined treatment of systemic lupus erythematosus (SLE) from the spleen and kidney aspect,by strengthening the spleen and kidney, invigorating qi and consolidating superficies, nourishing yin and cooling blood, activating blood circulation and removing blood stasis, clearing away heat and toxin. And one proven case is presented.关键词：systemic lupus erythematosus;treatment from the spleen and kidney;experience of famous doctor;Su Li
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发布时间：2022-08-31 - 摘要：This paper introduces Professor Yang Wei’s experience in treating perianal abscess. Professor Yang believes that the pathogenesis of this disease is mainly based on the accumulation of dampness and heat, qi stagnation and blood stasis. When the course of the disease is lingering for a long time, the symptoms of qi and blood consumption, yin deficiency and lingering toxin may occur. It is proposed to treat the disease with the “expulsion” method first, then invigorating qi and blood, besieging external pathogenic factors, and to treat the disease by stages. Gangyong prescription, a self-made empirical formula, is used to treat the disease with remarkable effect. And three proven cases are presented.关键词：perianal abscess;Gangyong prescription;experience of famous doctor;Yang Wei
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发布时间：2022-08-31 - 摘要：This paper introduces the clinical experience of Cheng Yiqin in treating plasma cell mastitis. Cheng Yiqin considers that the root of its pathogenesis is disharmony of the liver and spleen, obstruction of mammary collaterals, and the branch is stagnation of qi, turbid phlegm, blood stasis and heat toxicity. In the treatment of the disease, He emphasizes that traditional Chinese medicine should be considered first with syndrome differentiation, combining Chinese medinine with Western medicine to obtain good therapeutic efficacy. He alse pays attention to the patients’ life style for prevention of the disease. When prescribing herbs to treat the disease, he stresses the methods of soothing the liver and clearing away heat, as well as regulating nutrient qi and drainig toxin. And one proven case is presented.关键词：plasma cell mastitis;treatment based on syndrome differentiation;clinical experience;Cheng Yiqin
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发布时间：2022-08-31 - 摘要：Through literature review and statistical analysis of the application of meridian-guiding herbs in the treatment of hair loss, the authors investigated the rule of using meridian-guiding herbs in the treatment of hair loss. They found that the most commonly used meridian-guiding herbs were wind herbs, mainly the herbs used to expel external wind, followed by the herbs to stop internal wind.关键词：meridian-guiding herbs;hair loss;expelling wind herbs;experience summary
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发布时间：2022-08-31 - 摘要：From the perspective of monarch-herbs, the commonly used insomnia prescriptions in ancient and modern clinical practices are divided into 10 categories with 28 prescriptions involved. At the same time, the pathogenesis, indication, representative prescriptions and main points of each prescription were summarized.关键词：insomnia;prescription;indication;medical case
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发布时间：2022-08-31 - 摘要：Taking cervical spondylosis and lumbar spondylosis as examples, this paper summarizes the idea of holistic treatment of spine with neck, shoulder, waist and leg pain as the main complaint based on the viewpoint of anatomy and biomechanics. It is suggested that the basic concept consistent with the meridian system can be found from the viewpoint of spine holism, which can be used to guide the diagnosis and treatment of diseases by acupuncture and moxibustion. And four proven cases are presented.关键词：acupuncture and moxibustion;holism;treatment based on syndrome differentiation;anatomy;biomechanics;spine holism
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发布时间：2022-08-31 - 摘要：This paper introduces the formation process of academic thoughts of Professor Xu Fusong, a famous andrologist, and summarizes his academic thoughts and clinical experience. The details are as follows: ①To trace the classics, structure the system and standardize the names and treatment of diseases in andrology. ②To establish the outline, advocate new theory, promote and sublimate innovative theory of andrology. ③To improve the thinking of andrology on diagnosis and treatment by valuing the whole and identifying the correlation. ④To emphasize the kidney as the pivot in andrology by identifying pathogenesis and differentiating the internal from the external. ⑤To accept new knowledge, focus on scientific research, and develop andrology in traditional Chinese medicine by integrating traditional Chinese and Western medicine.关键词：Xu Fusong;andrology in traditional Chinese medicine;academic thinking;clinical experience
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发布时间：2022-08-31 - 关键词：Lu Yuanlei;academic achievement;book;improvement of TCM;integrated Chinese and Western medicine
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发布时间：2022-08-31 - 摘要：This paper reviews the development of the International Classification of Diseases(ICD), introduces the structure, content and coding characteristics of the final version (ICD-11) of the eleventh revision of the International Classification of Diseases, and focuses on the analysis of the structure of its chapter on traditional medicine. Compared with the current classification standard of TCM syndrome in China, its practical application and significance to the development of traditional medicine are prospected.关键词：International Classification of Disease;ICD-11;traditional medicine
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发布时间：2022-08-31 - 摘要：Objective:To explore the methods for preventing and treating hemorrhoids with traditional Chinese medicine (TCM) based on epidemiological investigation in rural communities in Fengxian District, Shanghai. Methods6,0 residents aged 18-80 years in five rural communities in Fengxian District were randomly selected for epidemiological investigation, including general conditions, personal habits, medical history, hemorrhoids-related examination and TCM syndrome types of hemorrhoids. The epidemiological characteristics of hemorrhoids in rural communities and its correlation with various influencing factors were analyzed. Results:①A total of 5,7 effective questionnaires were collected, with a recovery rate of 98.28%. ②In the surveyed population, the total prevalence rate of hemorrhoids was 40.27%, and it was higher in females (46.22%) than in males (32.30%). The three hemorrhoids were mixed hemorrhoids, external hemorrhoids and internal hemorrhoids in prevalence rate from high to low. Hemorrhoids were distributed in all age groups, with the highest prevalence in the 35-59 age group. ③The syndrome of spleen deficiency and qi depression (36.97%) and the syndrome of dampness-heat pouring downward (43.66%) accounted for the majority (80.63%) of the clinical syndromes in hemorrhoids. ④Drinking, spicy food, poor bowl habit as well as sitting, standing and walking for a prolonged time had a certain relationship with hemorrhoids. ⑤Multi-factor regression analysis showed that drinking, spicy diet, and poor bowel habits were the independent risk factors in occurrence of hemorrhoids, while increased intake of fruits and vegetables was an independent protective factor; poor bowel habits and standing and walking for a prolonged time were risk factors for the syndrome of spleen deficiency and qi depression, poor bowel habits and spicy diet were related to the syndrome of qi stagnation and blood stasis, spicy diet was a relevant risk factor for the syndrome of dampness-heat pouring downward, while increased intake of fruits and vegetables was the relevant protective factor against the syndrome of wind damaging intestinal collaterals. Conclusion:The prevalence of hemorrhoids in rural communities in Shanghai has exceeded 40% (40.27%). Females, the middle-aged and people with bad habits are the high-risk groups of this disease. In prevention and treatment of this disease, the young people should be the focus of “prevention before disease onset”. In addition, it is advisable to pay attention to women’s health and personal daily diet, provide TCM health education, integrate the knowledge about hemorrhoids prevention into daily life, develop good living habits, and give full play to the role of medical “triple” in district hospitals of Chinese medicine or an effective coping strategy.关键词：hemorrhoids;prevalence rate;rural communities;epidemiological investigation;prevention and treatment with traditional Chinese medicine
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发布时间：2022-08-31 - 摘要：Objective:To study the distribution of traditional Chinese medicine (TCM) syndromes,Helicobacter pylori(Hp) infection and pathological changes of gastric mucosa in chronic atrophic gastritis. MethodsThe related data of 338 patients with chronic atrophic gastritis were collected. The distribution of TCM syndromes, Hp infection and pathological changes of gastric mucosa were analyzed. Results:①The syndrome of deficiency of spleen and stomach was the most common in patients with chronic atrophic gastritis(23.4%), followed by dampness-heat of spleen and stomach (20.7%), stagnation of liver qi and stomach qi(19.2%), deficiency of stomach yin(13.3%), stagnated heat of liver and stomach(12.1%), and blood stasis in stomach collateral(11.2%).② The total Hp infection positive rate of 338 patients with chronic atrophic gastritis was 55.3%, which was highest in dampness-heat of spleen and stomach syndrome (72.9%); different syndromes of chronic atrophic gastritis had statistically significant difference in the rate of Hp infection (P<0.01) .③The total positive rate of gastric mucosa active inflammation was 53.8%, which was highest in dampness-heat of spleen and stomach syndrome(71.4%), The proportion of moderate and severe active inflammation was 37.1% and 27.1% respectively.There were statistically significant differences in the degree of active inflammation of gastric mucosa in different TCM syndromes (P<0.05).④The proportion of moderate and severe gastric mucosa atrophy in deficiency of spleen and stomach syndrome was the highest (43.0% and 27.8%, respectively).The degree of gastric mucosa atrophy in different TCM syndromes was statistically different(P<0.05).⑤There was no statistically significant difference between different TCM syndromes in chronic inflammation of gastric mucosa, intestinal metaplasia, and low-grade intraepithelial P>0.05). Conclusion:Deficiency of spleen and stomach syndrome is the most common TCM syndrome in patients with chronic atrophic neoplasia (gastritis, which has the higher incidence of moderate and severe gastric mucosa atrophy; dampness-heat of spleen and stomach syndrome is closely related to Hp infection, and the degree of gastric mucosa active inflammation is also more severe.关键词：chronic atrophic gastritis;traditional Chinese medicine syndromes;Helicobacter pylori;pathology
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发布时间：2022-08-31 - 摘要：Based on the analysis of modern evolution rule of the “later-decocting method” of Artemisiae Annuae Herba, combined with the research progress of ancient and modern literature and modern composition, it is considered that the “later-decocting method” neglects the important efficacy of “clearing up deficiency heat” of Artemisiae Annuae Herba, and conflicts with many clinical uses in ancient and modern times. The “later-decocting method” of Artemisiae Annuae Herba should correspond to its different efficacy and application purpose, rather than uniform regulation.
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发布时间：2022-08-31 - 摘要：Objective:To observe the effects of Feiyanning Recipe combined with Kangliu Zengxiao Recipe on cancer-related fatigue, immune function and tumor markers in patients with intermediate-terminal lung adenocarcinoma after chemotherapy. Methods132 patients with intermediate-terminal lung adenocarcinoma were randomly assigned into treatment group and control group, 66 patients in each group. The control group was given Kangliu Zengxiao Recipe and the treatment group was given Feiyanning Recipe combined with Kangliu Zengxiao Recipe. Both groups were treated for 3 months. Scores on the cancer fatigue scale (CFS) and the brief fatigue inventory (BFI) and immune-related indicators [CD3+, CD4+, CD8+, CD56+16(NK), CD19+] were observed. Changes in the levels of tumor markers (CEA, CA199, CYFRA21-1 and CA125) were also evaluated. Results:①124 patients completed the trial, including 63 in the treatment group and 61 in the control group. ②The body dimension, emotional dimension and total score in the BFI and CFS scores were significantly lower in the treatment group than in the control group after treatment (P<0.05). ③The levels of CD3+, CD4+, CD8+ and CD56+16 (NK) were significantly higher in the treatment group than in the control group after treatment (P<0.05). ④The levels of CYFRA21-1 and CA125 were significantly lower in the treatment group tha in the control group after treatment (P<0.05). Conclusion:Compared with Kangliu Zengxiao Recipe alone, Feiyanning Recipe combined with Kangliu Zengxiao Recipe can better improve cancer-related fatigue in patients with intermediate-terminal lung adenocarcinoma after chemotherapy, increase the levels of peripheral blood lymphocytes and lower the levels of serum tumor markers (CYFRA21-1 and CA125), thereby improving prognosis and quality of life for the patients.关键词：lung adenocarcinoma;after chemotherapy;cancer-related fatigue;Chinese medicine treatment;immune function;tumor markers;Feiyanning Recipe
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发布时间：2022-08-31 - 摘要：Objective:To investigate the effects of Shidao Tongjie Granules combined with chemotherapy on disease-free survival (DFS) in the treatment of esophageal squamous cell carcinoma (ESCC) at stage IIB-IIIC after radical resection. MethodsA prospective, randomized, controlled study was performed in 106 patients with ESCC at stage IIB-IIIC after radical resection. The patients were randomly assigned into traditional Chinese medicine (TCM) + chemotherapy (TCM+CT) group (n=51) and chemotherapy (CT) group (n=55). DFS and 1-, 2- and 3-year DFS rates were calculated by Kaplan-Meier method in both groups. A log-rank univariate analysis was performed on factors with possible impact on DFS, and a multivariate analysis was carried out on the DFS-related prognosis factors using Cox proportional hazard model based on results of the univariate analysis. Results:①The median DFS was 34.6 and 23.3 months in the TCM+CT group and the CT group respectively, with statistically significant difference between the groups (P<0.05). ②The 1-, 2- and 3-year DFS rates were 76.5%, 58.0% and 42.2% in the TCM+CT group respectively, and 72.7%, 45.4% and 32.4% in the CT+TCM group respectively. ③The results of log-rank univariate analysis showed that scope of lymph node invasion, TNM staging, presence or absence of vascular cancer emboli and whether or not combined with TCM were the prognosis factors of DFS. ④The results of Cox multivariate analysis showed presence or absence of vascular cancer emboli and whether or not combined with TCM were the independent prognosisfactors of DFS in patients with ESCC at stage IIB-IIIC after radical resection. Conclusion:Shidao Tongjie Granules in combination with chemotherapy prolongs DFS, and presence or absence of vascular cancer emboli and whether or not combined with TCM are the independent prognostic factors of DFS in patients with ESCC at stage IIB-IIIC after radical resection.关键词：esophageal squamous cell carcinoma;stage ⅡB-ⅢC;postoperation;Shidao Tongjie Granules;chemotherapy;disease-free survival;prognosis
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发布时间：2022-08-31 - 摘要：Objective:To study the effects of Astragalus Angelica Mixture combined with tacrolimus on immune and renal functions in patients with refractory nephrotic syndrome. Methods126 patients with refractory nephrotic syndrome were assigned into treatment group and control group, 63 patients in each group. Patients in both groups were given tacrolimus and symptomatic treatment, and those in the treatment group were treated with Astragalus Angelica Mixture in addition. The treatment course was 6 months. Clinical efficacy, changes in T lymphocyte subsets (CD4+, CD8+, CD4+/CD8+), serum creatinine (SCr), urea nitrogen (BUN), glomerular filtration rate (GFR), 24 h urine protein quantitation and serum albumin level, as well as the occurrence of adverse reactions were observed. Results:①The total effective rate was 98.4% and 88.9% in the treatment group and the control group respectively; there were statistically significant differences in clinical efficacy between the groups (P<0.05). ②There were statistically significant differences in the levels of CD4+, CD8+ and CD4+/CD8+ in both groups after treatment compared to those before treatment (P<0.05); after treatment, the level of CD8+ was lower in the treatment group than in the control group, and the levels of CD4+ and CD4+/CD8+ were higher in the treatment group than in the control group, with statistically significant differences (P<0.05). ③The levels of SCr, BUN, 24 h urinary protein quantitation and serum albumin improved in both groups after treatment compared to those before treatment (P<0.05); after treatment, the levels of SCr, BUN and 24 h urinary protein quantitation were lower in the treatment group than in the control group, and the levels of serum albumin and GFR were higher in the treatment group than in the control group, with statistically significant differences (P<0.05). ④During the trial, the incidence of adverse reactions in the treatment group (11.11%) was significantly lower than that in the control group (31.74%) (P<0.05). Conclusion:Astragalus Angelica Mixture combined with tacrolimus has superior clinical efficacy to tacrolimus alone in the treatment of refractory nephrotic syndrome, which significantly improves immune and renal functions and is safe.关键词：refractory nephrotic syndrome;integrated Chinese and Western medicine therapy;tacrolimus;Astragalus Angelica Mixture;immunity
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发布时间：2022-08-31 - 摘要：Objective:To observe the clinical efficacy of acupoint massage in the treatment of Moroccan patients with lumbar disc protrusion. MethodsSixty patients with lumbar disc protrusion were assigned into two groups, 30 Chinese patients in a group and 30 Moroccan patients in the other. Both groups were treated with massage on acupoints along the bladder channel of foot-Taiyang and other relevant acupoints, three times a week for 2 weeks. Changes in patients` condition were observed with PRI, VAS and PPI questionnaire. Results:After treatment, the scores of PRI, VAS and PPI were reduced significantly in each group (P<0.05); the scores were significantly lower in the Moroccan group than in the Chinese group after treatment (P<0.05). Conclusion:Acupoint massage relieves the clinical symptoms in patients with lumbar disc protrusion, with better efficacy in Moroccan patients than in Chinese patients.关键词：lumbar disc protrusion;acupoint;massage;Moroccans
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发布时间：2022-08-31 - 摘要：Objective:To observe the therapeutic effect of Yangyin Xiaozheng Recipe on diabetic intracerebral microlesions in rats. MethodsExcept for 6 rats in the normal control group, 24 Wistar rats were used to establish the rat model of diabetic intracerebral microlesions, and were divided into three groups after successful modelling: high glucose injury group, aspirin control group and traditional Chinese medicine (TCM) group. The corresponding drugs were given by enema for 3 months in each group. The changes of intracerebral microlesions in rats were detected by biochemistry and flow cytometry (PI), and the changes of HIF-1α were detected by real-time PCR and Western blot. Results:①The results of HbA1c absorbance and apoptotic rate detected by flow cytometry showed that compared with the high glucose injury group, the HbA1c absorbance and apoptotic rate were reduced in the aspirin group and the TCM group, and there were significant differences among the groups (P<0.05). Compared with the aspirin group, the expression of HbA1c absorbance decreased significantly (P<0.05) and the apoptotic rate in early and late stages decreased significantly (P< 0.05) in the TCM group. ②Real-time PCR and Western blot showed that HIF-1α mRNA and protein expression were lowered in the aspirin group and the TCM group compared with the high glucose injury group (P<0.05), and there were significantdifferences among the groups (P<0.05). Compared with the aspirin group, HIF-1α mRNA and protein expression were reduced significantly in the TCM group (P<0.05). ③Immunohistochemistry showed that the number of cells with positive HIF-1α expression decreased in the aspirin group and the TCM group compared with the high glucose injury group (P<0.05); there was significant difference in the number of cells with positive HIF-1α expression between the aspirin group and the TCM group (P<0.01). Conclusion:Yangyin Xiaozheng Recipe has a certain effect in the treatment of diabetic intracerebral microlesions and reduces the HbA1c absorbance, the apoptotic rate of brain neurons and the expression of HIF-1α.关键词：diabetes;intracerebral microlesions;rats;Yangyin Xiaozheng Recipe;HIF-1α
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发布时间：2022-08-31 - 摘要：Objective:To investigate the protective effects of Qingchang Suppository (QCS) medicated serum on lipopolysaccharide (LPS)-induced Caco-2 cell injury model. MethodsCaco-2 cells in logarithmic growth phase were collected and divided into five groups: normal control group, LPS group, low-dose QCS group (2.5% QCS medicated serum), medium-dose QCS group (5% QCS medicated serum) and high-dose QCS group (10% QCS medicated serum). MTT assay was used to detect cell viability; ELISA was used to determine the content of IL-8, IL-17 and PGE2, and the levels of MDA, GSH and SOD in the supernatant; scratch assay was employed to test cell migration ability in vitro; Western blot was used to detect the expression of RhoA and Rac1 proteins. Results:QCS antagonized the decrease in Caco-2 cell viability induced by LPS. Compared with the LPS group, QCS significantly reduced the secretion of IL-8, IL-17 and PGE2 induced by LPS (P<0.05), lowered the release of MDA induced by LPS and increased the secretion of GSH and SOD (P<0.01); the scratch width in the QCS group decreased significantly and the cell migration ability increased at 48 h (P<0.001), which speeded up the repair of scratches in a concentration-dependent manner; Western blot results showed that QCS could effectively reverse LPS-induced inhibition of RhoA and Rac1 protein expression (P<0.05). Conclusion:Qingchang Suppository medicated serum protects Caco-2 cells from LPS-induced injury and increases cell survival rate by inhibiting inflammatory factors and antioxidant stress and promoting migration of colonic epithelial cells.关键词：Qingchang Suppository;Caco-2 cells;lipopolysaccharide;RhoA;Rac1;cell culture
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发布时间：2022-08-31 - 摘要：Objective:To observe the effects of Yinchenhao Decoction on the endoplasmic reticulum stress apoptosis pathway in rats with alcoholic liver fibrosis, and to explore the mechanism of Yinchenhao Decoction against alcoholic liver fibrosis. Methods40 SD rats were given liquor-corn oil-pyrazole mixture by gavage and low-dose CCl4 by intraperitoneal injection to replicate the rat model of alcoholic liver fibrosis. After 8 weeks, the model animals were randomly assigned into blank group, model group and low- and high-dose Yinchenhao Decoction groups, 10 rats in each group. The model group was given continuously with low dose of liquor mixture (6 mL/kg), Yinchenhao Decoction was given at 1.75 g/kg (5 mL/kg) and 3.5 g/kg (10 mL/kg) respectively in the low- and high-dose groups. The control group was given 0.9% NaCl solution of equal volume by gavage. 4 weeks later, the liver index and the levels of serum AST and ALT were determined; the proportion of hepatocyte suspension apoptosis rate in each Yinchenhao Dcoction group was determined by flow cytometry; Western blot was used to detect the expression of GRP78, Cleaved-Caspase-12 and Cleaved-Caspase-3 in liver of rats in each group. Results:①Compared with the control group, the liver index increased significantly in the model group (P<0.05); compared to the model group, the liver index decreased significantly in the Yinchenhao groups (P<0.05); compared with the low-dose Yinchenhao group, the index decreased significantly in the high-dose Yinchenhao group (P<0.05). ②Compared to the control group, the levels of ALT and AST in serum increased significantly in the model group (P<0.05); compared to the model group, the levels of ALT and AST in serum decreased significantly in the Yinchenhao groups (P<0.05); compared with the low-dose Yinchenhao group, the levels decreased significantly in the high-dose Yinchenhao group (P<0.05). ③Compared to the control group, the late and total apoptosis rates increased significantly in the model group (P<0.05); compared to the model group, the late and total apoptosis rates decreased significantly in the Yinchenhao groups (P<0.05); compared with the low-dose Yinchenhao group, the early, late and total apoptosis rates decreased significantly in the high-dose Yinchenhao group (P<0.05). ④Compared to the control group, the expression level of Cleaved-Caspase-3 was upregulated significantly in the model group (P<0.05); compared to the model group, the expression levels of GRP78, Cleaved-Caspase-12 and Cleaved-Caspase-3 were downregulated significantly in the Yinchenhao groups (P<0.05); compared with the low-dose Yinchenhao group, the expression levels of GRP78 and Cleaved-Caspase-12 were downregulated significantly in the high-dose Yinchenhao group (P<0.05). Conclusion:Yinchenhao Decoction can significantly improve liver tissue damage in rats with alcoholic liver fibrosis and inhibit hepatocyte apoptosis mediated by endoplasmic reticulum stress.关键词：Yinchenhao Decoction;alcoholic liver fibrosis;rats;endoplasmic reticulum stress;cell apoptosis
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发布时间：2022-08-31 - 摘要：Objective:To explore the effects of water and alcohol extracts of Erzhi Pills on splenic cells and ovarian granulose cells in mice. MethodsThe splenic mononuclear cells and ovarian granulosa cells were cultured in vitro. ①Water extract of Erzhi Pills at a concentration of 0.96 g/L was added to the splenic cells in the water extract group, alcohol extract of Erzhi Pills at a concentration of 1.920 g/L in the alcohol extract group, lentinan at a concentration of 0.1 g/L in the positive control group and culture medium in the blank control group. ②Water extract of Erzhi Pills at a concentration of 0.96 g/L was added to the ovarian granulose cells in the water extract group, alcohol extract of Erzhi Pills at a concentration of 0.72 g/L in the alcohol extract group, lentinan at a concentration of 0.2 g/L in the positive control group and culture medium in the blank control group. Cell proliferation was detected by MTT; ELISA was used to determine the concentrations of IL-1 and E2 in the culture supernatant; fluorescence quantitative real-time PCR (QRT-PCR) was used to detect mRNA expression of IL-1 receptor (IL-1R) and estradiol receptor (ERα); the levels of IL-1R and ERα were detected by flow cytometry. Results:①Compared with the blank control group, water and alcohol extracts of Erzhi Pills promoted proliferation of the splenic cells and ovarian granulose cells significantly (P<0.01), and alcohol extract showed a stronger effect than water extract in promoting proliferation of the splenic cells (P<0.05). ②Water and alcohol extracts of Erzhi Pills promoted the ovarian granulose cells to produce more E2 (P<0.05) and the splenic cells to produce more IL-1 (P<0.01). ③Compared with the blank control group, the expression level of ERα in the splenic cells increased significantly in the water and alcohol extract groups (P<0.01), which was consistent with the results in the lentinan group (P>0.05), and the expression level of ERα in the alcohol extract was higher than that in the water extract group (P<0.05). ④The expression of IL-1R on the surface of ovarian granulose cells increased significantly both in the water and alcohol extract groups (P<0.05), consistent with the results in the lentinan group (P>0.05), but there were no statistically significant differences between them (P>0.05). Conclusion:The water and alcohol extracts of Erzhi Pills have a good bi-directional promoting effect on the reproductive, endocrine and immune systems of mice through direct regulation of ovarian granulose cells and splenic cells, and the effect of alcohol extract was better than that of water extract.关键词：splenic cells;ovarian granulose cells;cell culture;Erzhi Pills;water extract;alcohol extract
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发布时间：2022-08-31 - 摘要：Objective:Using Chuanxiong extract as a model drug and ferulic acid as a content indicator, cyclodextrin (CD) and chitosan (CS) were prepared into a nasal thermosensitive gel by using the polymer grafting process. Release of the drug was investigated in vitro, and pharmacodynamic investigation was performed on the treatment of migrane. MethodsThe chitosan molecular chain and the cyclodextrin inclusion complex were grafted by chemical reaction, and solubility of the grafted product served as the main indicator. The effects of reaction time, temperature and concentration of the NaOH solution on solubility of the product were investigated. Infrared spectroscopy was used to confirm whether cyclodextrin was successfully grafted with chitosan. Taking gelatin time as an indicator, the effects of β-glycerol phosphate disodium (β-GP) concentration, CS-CD ratio and pH value on it were investigated. Drug release performance was assessed based on drug release in vitro. The writhing response of rats was observed by intraperitoneal injection of glacial acetic acid. The acute blood stasis model was prepared by adrenaline injection-ice bath. Plasma viscosity and endothelin (ET-1) content were determined with blood collected from the common carotid artery. Results:The NaOH concentration was 1 mol/L, and the mixture was stirred for 8 h at 20°C. The β-GP concentration was 56%, the CS-CD ratio was 0.8 and the pH value was 7. Chuanxiong extract thermosensitive gel could prolong the writhing latency of rats, reduce the number of writhing, lower plasma viscosity and plasma ET-1 content. Conclusion:The cyclodextrin-grafted-with-chitosan thermosensitive gel incorporating Chuanxiong extract has simple preparation process, good sustained-release effect and excellent treatment effect on migraine.关键词：Chuanxiong extract;HP-β-CD;chitosan;thermosensitive gel;migraine
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发布时间：2022-08-31 - 摘要：This paper reviews the current status of research on chemical constituents of Pinellia Pedatisecta Schott and its pharmacological effects.Pinellia Pedatisecta Schott mainly contains alkaloids,dipeptides,amino acids,lectin,and other chemical components,and has antitumor,antioxidant,anticonvulsant,anti-aging,sedative,anti-arrhythmia and other pharmacological effects.关键词：Pinellia Pedatisecta Schott;chemical constituents;pharmacological effects;review
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发布时间：2022-08-31 - 摘要：The research progress of acupuncture and moxibustion on the bidirectional regulation of mast cells was reviewed. Acupuncture has two-way regulation on mast cells:under physiological conditions,acupuncture and moxibustion stimulation can cause an increase in the number of local mast cells and degranulation; under pathological conditions, mast cells in local lesions are abnormally increased, and the number of mast cells and degranulation in the lesion area after acupuncture and moxibustion is significantly reduced.关键词：acupuncture and moxibustion;mast cells;degranulation;two-way regulation;review
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发布时间：2022-08-31
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