最新刊期
期 5 ， 2019
- 摘要：This paper introduces the clinical experience of treating knee osteoarthritis with insect drugs in the department of Shi’s Traumatology. Knee osteoarthritis is a chronic disease, which is often treated based on qi-blood-phlegm -stasis theory in Shi’s Traumatology and in combination with the use of insect drugs for dredging meridians and activating collaterals, resolving phlegm and removing blood stasis . The insect drugs such as Jiangcan(Bombyx Batryticatus), Tubiechong(Eupolyphaga Seu Steleophaga), Dilong(Lumbricus), Wugong(Scolopendra) have the function of stopping pathogenic wind and resolving phlegm, activating collaterals and relieving pain, removing toxic materials and dispersing nodules, and with their migratory nature, the treatment effect of those drugs is relatively quick. And one proven case is presented.关键词：knee osteoarthritis;insect drugs;Shi’s traumatology
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发布时间：2022-08-31 - 摘要：This article introduces Professor Zhang Yuping’s experience in treating alopecia areata. It is considered that the pathogenesis is rooted in weakness of qi and blood, insufficiency of the liver and kidney, with pathogenic wind invasion, qi stagnation and blood stasis as its branch. The root of the disease is treated by replenishing qi and nourishing blood, and by nourishing the liver and supplementing the kidney, together with dispelling pathogenic wind and clearing away heat, and promoting blood circulation and dissipating the phlegm for the branch. Alopecia areata basic prescription, which is created for oral administration, is used in combination with those for external application. And one proven case is presented.关键词：alopecia areata;traditional Chinese medicine therapy;clinical experience;Zhang Yuping
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发布时间：2022-08-31 - 摘要：This paper introduces Han Yanhua’s clinical experience in treating chronic pelvic pain. It is considered that the liver is responsible for the changes. The main pathogenesis of the disease lies in stagnation of qi and blood stasis, accumulation of dampness and heat, stagnation of cold-dampness, weakness of viscera, and the key is blood stasis. The therapeutic method is activating blood circulation to remove blood stasis, promoting qi flow to relieve pain, emphasizing the compatibility of soothing-liver-to-regulate-qi herbs and activating-blood-circulation ones . Han’s Fuyan Decoction, an experience prescription, is often used. And one proven case is presented.关键词：sequelae of pelvic inflammatory diseases;chronic pelvic pain;clinical experience;Han’s Fuyan Decoction;Han Yanhua
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发布时间：2022-08-31 - 关键词：mammary abscess;acute mastitis;external therapy;experience of famous doctors;Chen Hongfeng
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发布时间：2022-08-31 - 摘要：This paper discusses the experience of Professor Wang Lingtai in treating jaundice based on Synopsis of the Golden Chamber . It is considered that the internal obstruction of damp-heat,cold-dampness and blood stasis is the major etiology and pathogenesis of jaundice,and the treatment principle for Jaundice is clearing away heat and removing dampness accompanied with the eight treatment methods. The prescriptions such as Yinchenhao Decoction,Zhizi Dɑhuɑnɡ Decoction,Shenling Baizhu Powder are often used . And one proven case is presented.关键词：jaundice;Synopsis of the Golden Chamber;experience of famous doctor;Wang Lingtai
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发布时间：2022-08-31 - 关键词：Lu Yuanlei;biography;book;integrated Chinese and Western medicine
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发布时间：2022-08-31 - 摘要：Exogenous febrile disease, six meridians and prescription-syndrome are unrelated when seen separately and are well-integrated when seen together. Thinking of exogenous febrile disease from the viewpoint of disease, understanding the six meridians by considering the regular patterns of syndromes and treatment, and comprehending prescriptions and syndromes at different levels, the three highlight the basic pattern of clinical diagnosis and treatment in traditional Chinese medicine.关键词：exogenous febrile disease;six meridians;prescription-syndrome;pattern of clinical diagnosis and treatment
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发布时间：2022-08-31 - 摘要：Gastroesophageal reflux disease (GERD) is one of the most easily misdiagnosed diseases in Western medicine. Through reviewing the relevant literature in ancient and modern times and combining with his own practical experience, the author considers that there are also many misunderstandings in differentiation of GERD in traditional Chinese medicine. On the one hand, because the clinical manifestations of GERD are very complex, especially lack of typical reflux symptoms in many patients with extraoesophageal manifestations, it may be misidentified as lung, heart, liver and kidney diseases. On the other hand, as some of the symptoms of GERD are very special, such as the typical manifestations of sour regurgitation, heartburn, as well as possible accompanying symptoms such as bitter mouth, dry mouth, bad breath, gingival bleeding, oral ulcers, these symptoms, which appear to have obvious febrile characteristics, may be caused due to spleen-stomach qi deficiency, spleen-stomach deficiency cold or turbid phlegm obstruction in middle energizer. Therefore, in differentiation of the symptoms and signs of GERD, TCM doctors must first make clear the diagnosis of the disease by means of modern medical examination and correctly understand its pathogenesis, and then work out accurate differentiation of the location and nature of the disease, finally giving correct treatment according to the manifestations of the tongue and the pulse and other symptoms as well as the valuable experience accumulated by the ancient and modern physicians.关键词：gastroesophageal reflux disease;extraoesophageal manifestations;silent gastroesophageal reflux;misdiagnosis;misidentification
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发布时间：2022-08-31 - 摘要：By combing the development of RNA interference (RNAi) drugs, the mechanism of action of the first RNAi drug was analyzed, and the enlightenment to the modernization of Chinese herbal medicine was expounded based on the research progress of miRNA in plant medicines. It is suggested that miRNA derived from Chinese herbal medicine may become a new class of natural bioactive RNA interference drugs, which need to be paid attention to and studied.关键词：modernization of Chinese herbal medicine;microRNA(miRNA);RNAi(RNA interference)
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发布时间：2022-08-31 - 摘要：Objective:To detect the hemorheological indicators and expression of pro-angiogenic factors in blood stasis syndrome and non-blood stasis syndrome of patients with colorectal cancer (CRC), and analyze the relationship between blood stasis syndrome and blood hypercoagulability as well as tumor angiogenesis. Methods839 patients including retrospective and prospective cases were assigned into blood stasis syndrome group and non-blood stasis syndrome group. The hemorheological indicators in the whole blood of the patients were measured by plasma separation technique, and the changes of these indicators were analyzed. The expression of pro-angiogenic factors (Angiogenin, ANG-2, EGF, bFGF, HB-EGF, HGF, Leptin, PDGF-BB, PIGF and VEGF) in serum was detected by protein chip technique, and differences in expression were analyzed. Results:①In general, the proportion of patients with blood stasis syndrome and non-blood stasis syndrome was about 1∶4 in CRC patients. ②The preoperative erythrocyte sedimentation rate and K value of blood sedimentation equation in the blood stasis syndrome group were significantly higher than normal value in both male and female patients, and were also significantly higher than the corresponding levels in the non-blood stasis syndrome group (P<0.05). Meanwhile, the post-operative erythrocyte sedimentation rate and K value of blood sedimentation equation also presented consistent changes, and the corresponding levels of males and females in the blood stasis syndrome group were significantly higher than those in the non- blood stasis syndrome group (P<0.05). ③The average fibrinogen level of males and females in the blood stasis syndrome group was significantly higher than that in the non-blood stasis syndrome group in preoperative CRC patients (P<0.05). The post-operative fibrinogen levels of males and females in both groups were within the normal range on average, with no statistically significant differences between the groups (P>0.05). ④The expression levels of Angiogenin, Ang-2, EGF, bFGF, HB-EGF, HGF, Leptin, PDGF-BB, PIGF and VEGF in serum were significantly higher in the blood stasis syndrome group than in the non-blood stasis syndrome group in CRC patients (P<0.05). Conclusion:Compared to CRC patients with non-blood stasis syndrome, those with blood stasis syndrome showed a high coagulation state, and the expression of pro-angiogenic factors was significantly higher, suggesting a close relationship between blood stasis syndrome in traditional Chinese medicine and tumor angiogenesis in western medicine.
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发布时间：2022-08-31 - 摘要：This paper summarizes the clinical characteristics of Ye Bingren’s treatment of digestive system, respiratory system, cardiac and cerebral vascular system and miscellaneous diseases with Jingfang(Classical Prescriptions), and analyses the reasons why he attached importance to Jingfang. It is considered that his experience has a positive effect on the clinical application of Jingfang, the study and the popularization of the formulas, especially the formation of the “prescription-disease-person mode of thinking”.关键词：Ye Bingren;Jingfang;clinical experience
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发布时间：2022-08-31 - 摘要：This paper explores and summarizes the characteristics and patterns of ying-wei production and physiological function as well as pathogenesis of ying-wei disharmony in Lingshu Jing. Ying qi and wei qi come from the essence of digested food. Wei qi has the functions of nourishing and enriching, warming the body, opening and closing the striae and interstices, and resisting pathogenic factors; ying qi has the functions of generating blood, assisting blood circulation and nourishing the body. Nine conditions of ying-wei deficiency or circulation abnormality, such as ying qi deficiency and wei qi subjugation, ying-wei deficiency and ying-wei retention, can lead to “ying-wei disharmony”.关键词：ying-wei disharmony;Lingshu Jing;pathogenesis;mechanism
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发布时间：2022-08-31 - 摘要：The ancient people’s understanding of etiology and pathogenesis and their thinking on prevention and treatment of epidemic disease in the pre-Qin period are studied by exploring the descriptions of epidemic disease in Shan Hai Jing. In prevention and treatment of epidemic disease, Shan Hai Jing has the characteristics of prevention before disease onset, preferred use of drugs that were sour and sweet in property and paying attention to external treatment. It is of great value in exploring the origin of epidemic disease and guiding modern diagnosis and treatment of the disease.关键词：Shan Hai Jing;epidemic disease;traditional Chinese medicine;prevention and treatment
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发布时间：2022-08-31 - 摘要：Objective:To observe the clinical efficacy of Kangliu Jiandu recipe combined with Shenqi Fuzheng injection in improving cancer-related fatigue in patients with intermediate-terminal non-small cell lung cancer (NSCLC). Methods80 NSCLC patients with cancer-related fatigue were randomly assigned into treatment group and control group, 40 patients in each group. Both groups were given chemotherapy, and during chemotherapy the control group was administered Sijunzi decoction or Shashen Maidong decoction, and the treatment group was treated with Kangliu Jiandu recipe combined with Shenqi Fuzheng injection. The course of treatment was 16 weeks. Changes in the scores on Piper fatigue scale, the Quality of Life Questionnaire-Cancer (QLQ-C30) scores, blood routine, natural killer (NK) cells, T lymphocyte subsets (CD3+, CD4+, CD8+, CD4+ /CD8+), interleukin-6 (IL-6) levels were compared between the two groups. Results:①=1\*GB3There were 2 and 3 drop-outs in the treatment group and the control group respectively. 75 patients completed the trial, including 38 and 37 patients in the treatment group and the control group respectively. ②After treatment, there was better improvement of fatigue symptoms in the treatment group than in the control group (P<0.05), and the quality of life was higher in the treatment group than in the control group (P<0.05). ③=3\*GB3After treatment, the levels of hemoglobin, white blood cells and absolute neutrophils were reduced in both groups compared to those before treatment (P<0.05); and the levels were higher in the treatment group than in the control group (P<0.05). ④There were no significant differences in the levels of immune indexes (NK, CD3+, CD4+, CD8+, CD4+/CD8+, IL-6) in the treatment group before and after treatment (P>0.05), while the levels showed significant differences in the control group before and after treatment (P<0.05). The levels of NK, CD4+, IL-6 and CD4+/CD8+ were higher in the treatment group than in the control group after treatment (P<0.05). Conclusion:Kangliu Jiandu recipe combined with Shenqi Fuzheng injection can significantly improve the fatigue symptoms and quality of life in patients with intermediate-terminal non-small cell lung cancer, and the mechanism of action may be related to relieving bone marrow depression and regulating immune function.关键词：non-small cell lung cancer;cancer-related fatigue;Kangliu Jiandu Recipe;Shenqi Fuzheng injection;T lymphocyte subsets
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发布时间：2022-08-31 - 摘要：Objective:To observe the effect of acupoint massage in promoting gastrointestinal function recovery after radical gastrectomy for gastric cancer. Methods100 patients after radical gastrectomy for gastric cancer were randomly assigned into treatment group and control group, 50 patients in each group. Both groups were given routine post-operative treatment and the treatment group received acupoint massage (Neiguan, Zusanli and Hegu) in addition. After intervention for 5 days, changes in the levels of gastrointestinal hormones [gastrin (GAS), motilin (MOT)] and gastrointestinal symptom scores were compared, and the recovery time of bowel sounds, the first time of anal exhaust, the first time of defecation and the time of general diet were observed in the groups. Results:①=1\*GB3After 5 days of intervention, the serum levels of GAS and MOT increased in both groups compared to those before intervention (P<0.05), and they were higher in the treatment group than in the control group (P<0.05). ②After 5 days of intervention, the scores of abdominal distension, belching, gastric burning, nausea and vomiting decreased in both groups compared to those before intervention (P<0.05) and they were lower in the treatment group than in the control group (P<0.05). ③=3\*GB3The recovery time of bowel sounds, the first time of anal exhaust, the first time of defecation and the time of general diet were earlier in treatment group than in the control group (P<0.05). Conclusion:Acupoint massage promotes the recovery of gastrointestinal function in patients after radical gastrectomy for gastric cancer.关键词：gastric cancer;after radical gastrectomy;gastrointestinal function;acupoint massage;gastrointestinal hormones
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发布时间：2022-08-31 - 摘要：Objective:To observe the effects of modified Wuhu Zhuifeng powder on serum levels of interleukin (IL)-1β, Cystatin (Cys)-C and homocystein (Hcy) and motor sysmptoms in patients with Parkinson’s disease (PD). Methods108 patients with PD were randomly assigned into treatment group and control group, 54 patients in each group. Patients in both groups were given levodopa and benserazide hydrochloride tablets, and the treatment group was given modified Wuhu Zhuifeng powder in addition. The course of treatment was 3 months. Medication safety was observed. Changes in the serum levels of IL-1β, Cys-C and Hcy, and in scores on the Unified Parkinson’s Disease Rating Scale (UPDRS) and Parkinson’s Disease Questionnaire (PDQ-39) were compared. Results:①104 patients completed the trial, including 53 and 51 patients in the treatment group and the control group respectively. ②After treatment, the UPDRSⅡ, UPDRSⅢ, UPDRSⅣ and PDQ-39 scores decreased significantly in both groups compared to those before treatment (P<0.05). The scores were significantly lower in the treatment group than in the control group after treatment (P<0.05). ③After treatment, the levels of IL-1β, Cys-C and Hcy decreased in both groups compared to those before treatment (P<0.05). The levels were significantly lower in the treatment group than in the control group after treatment (P<0.05). ④There were no significant differences in the incidence of adverse drug reactions between the groups (P>0.05). Conclusion:In treating PD, modified Wuhu Zhuifeng powder can effectively lower the serum levels of IL-1β, Cys-C and Hcy, significantly relieve the motor symptoms, reduce the adverse reactions of western medicine and improve the quality of life of the patients.关键词：Parkinson’s disease;modified Wuhu Zhuifeng Powder;interleukin-1β;cystatin-C;homocysteine;motor symptoms;synergism and attenuation
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发布时间：2022-08-31 - 摘要：Objective:To observe the effects of simplified wuqinxi on improving dynamic balance ability of the elderly. MethodsUsing the quasi-experiment research scheme, 60 volunteers were assigned into test group and control group, 30 in each group. Simplified wuqinxi was performed in the test group and stretching exercises were performed in the control group, with an exercise course of 4 months. The indicators of dynamic balance ability of the volunteers with eyes open and closed were observed on the Biodex balance tester. Results:①57 patients completed the experiment, including 29 and 28 volunteers in the test group and the control group respectively. ②With eyes open, there were no significant differences in the overall balance index, anterior-posterior balance index and left-right balance index between week 16 and week 0 in both groups (P>0.05). There were no significant differences in the overall balance index, anterior-posterior balance index and left-right balance index between the groups at week 0, week 8 and week 16 (P>0.05). ③The ANOVA analysis of repeated measurements showed that with eyes open, there was statistical significance in the time factor of intra-group variations of the overall balance index and anterior-posterior balance index (P<0.05), while there was no statistical significance in the time * group factor of all indicators (P>0.05), suggesting that there was no interaction between time and group. There was no significant difference in the group factor of the inter-group variations of all indicators (P>0.05). ④With eyes closed, in the test group, the overall balance index, anterior-posterior balance index and left-right balance index decreased significantly at week 8 compared to week 0, at week 16 compared to week 0 (P<0.05); there were significant differences in the overall balance index, anterior-posterior balance index and left-right balance index between week 16 and week 8 (P<0.05). In the control group, the overall balance index and anterior-posterior balance index decreased significantly at week 16 compared to week 0, at week 16 compared to week 8 (P<0.05); and the left-right balance index decreased significantly at week 16 compared to week 0, at week 8 compared to week 0 (P<0.05). There was significant difference in the overall balance index between the groups at week 8 (P<0.05); there were significant differences in the overall balance index and left-right balance index between the groups at week 16 (P<0.05). ⑤The ANOVA analysis of repeated measurements showed that with eyes closed, there was statistical significance in the time factor of intra-group variations of the overall balance index, anterior-posterior balance index and left-right balance index (P<0.05), while there was no statistical significance in the time * group factor of all indicators (P>0.05), suggesting that there was no interaction between time and group. There was statistical significance in the group factor of the inter-group variations of the overall balance index and left-right balance index (P<0.05). Conclusion:Simplified wuqinxi exercise can increase the control ability and stability of the elderly’s upright posture, improve their dynamic balance ability, and the mechanism of action may be increasing sensitivity of the vestibular system and sensory system in the elderly.
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发布时间：2022-08-31 - 摘要：Objective:To investigate the regulatory effects of Yiqi Huoxue Huashi formula and its decomposed recipes on the podocyte slit membrane protein α-actinin-4 and CD2AP in rats with passive Heymann nephritis (PHN). MethodsMale Wistar rats were used to establish the classical PHN model. The successful modeling rats were randomly assigned into model group, cyclosporine group, Yiqi Huoxue Huashi formula group, Yiqi recipe group, Huoxue recipe group and Huashi recipe group. The normal rats were used as controls. The drug treatment groups were treated with the corresponding drug by intragastric administration, and the control and model groups were treated with equal volume of 0.9% NaCl solution. The treatment course was 6 weeks. Blood was drawn from the orbital venous plexus of rats at weeks 0,2, 4 and 6, and 24-hour urine was collected using metabolic cages. The serum levels of albumin (Alb), creatinine (SCr) and urea nitrogen (BUN), and the 24-hour urinary protein quantification (UPRO) were measured by automatic biochemical analyzer. After intervention, the kidneys were collected. The morphological changes of kidney tissues were observed under the light microscope after HE staining, and the morphological changes of glomerular basement membrane, podocytes and podocytic process were observed under the transmission electron microscope. The mRNA and protein expression levels of α-actinin-4 and CD2AP in kidney tissues were detected by PCR and Western blot. Results:①Compared with the control group, the levels of UPRO and SCR increased significantly (P<0.05) and the level of Alb decreased significantly (P<0.05) in the model group at each time point. Compared with the model group, the level of UPRO decreased significantly at weeks 4 and 6 (P<0.05), and the level of Alb decreased significantly at weeks 2,4 and 6 (P<0.05), while the levels of SCr and BUN increased significantly at weeks 2,4 and 6 (P<0.05) in the cyclosporine group. Compared with the model group, the level of UPRO decreased significantly in the Yiqi Huoxue Huashi formula group only at week 6 (P<0.05). Compared with the cyclosporine group, the levels of SCr and BUN decreased significantly in the Yiqi Huoxue Huashi formula group at weeks 2,4 and 6. ②Compared with the control group, results observed under the light microscope showed in the model group, the glomerulus was obviously enlarged, the basement membrane was diffusely thickened, the capillary loops were compressed and some renal tubular epithelial cells were swollen; under the electron microscope, it was revealed in the model group that there were a large number of electron dense deposits under the epithelium and the podocytic process were widely fused or disappeared. Compared with the model group, the glomerular lesions in all drug treatment groups were alleviated. ③Compared with the control group, the mRNA and protein expression levels of α-actinin-4 increased significantly (P<0.05), while those of CD2AP decreased significantly (P<0.05) in the model group. Compared with the model group, the mRNA and protein expression levels of α-actinin-4 were down-regulated significantly (P<0.05), while those of CD2AP were up-regulated significantly (P<0.05) in the cyclosporine group. Compared with the model group, the protein expression level of α-actinin-4 was down-regulated significantly in the Yiqi Huoxue Huashi formula group (P<0.05). ④Compared with the model group, the levels of UPRO, Alb, SCr and BUN showed no obvious changes in all of the decomposed recipe groups at each time point (P>0.05). Pathological observation showed that glomerular injury was obviously relieved in all of the decomposed recipe groups compared with the model group. Compared with the model group, the mRNA and protein expression levels of α-actinin-4 were down-regulated significantly in the Yiqi recipe group (P<0.05), while those of CD2AP were up-regulated significantly in the Huoxue recipe group (P<0.05). Conclusion:Yiqi Huoxue Huashi formula significantly reduces the urinary protein level and alleviates glomerular injury in PHN model rats, and the mechanism may be related to down-regulation of α-actinin-4 expression and up-regulation of CD2AP expression. Moreover, among its decomposed recipes, Yiqi recipe can inhibit α-actinin-4 expression and Huoxue recipe can promote CD2AP expression.关键词：Yiqi Huoxue Huashi formula;passive Heymann nephritis;idiopathic membranous nephropathy;podocyte slit membrane protein;α-actinin-4;CD2AP
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发布时间：2022-08-31 - 摘要：Objective:To investigate the changes in the expression of ghrelin in hypothalamus and stomach and the effects of liver-protective 919 syrup on it in rats with liver-depression, qi-stagnation and blood-stasis syndrome. Methods40 Wistar rats were randomly assigned into normal group, model group, and 919 syrup high-, medium-and low-dose groups (27,3.5 and 6.75 g·kg-1 respectively), 8 rats in each group. Excluding the normal group, the rat model of liver-depression, qi-stagnation and blood-stasis was established by acute tail entrapment method. The groups were given corresponding intervention for modelling for 21 days. Food intake and body mass of rats in each group were monitored during the process. After experiment, the serum acylated ghrelin concentrations in each group were determined by ELISA, and the ghrelin protein expression in stomach and hypothalamus was detected by Western blot. The mRNA expression of ghrelin, growth hormone secretagogue receptor (GSHR) and 5-hydroxytryptamine 2b receptor (5-HT2bR) in the stomach and the mRNA expression of ghrelin and 5-HT2cR in the hypothalamus were measured by RT-PCR. Results:Compared to the normal group, the level of serum acylated ghrelin was significantly increased (P<0.01), the expression of ghrelin protein in hypothalamus and stomach was increased (P<0.01), the mRNA expression ghrelin and GHSR in stomach and of ghrelin in hypothalamus were significantly increased (P<0.01), and the mRNA level of 5-HT2bR in stomach and 5-HT2cR in hypothalamus was significantly reduced (P<0.01) in the model group. Compared to the model group, 919 syrup could significantly reverse the increases in the level of ghrelin in serum, stomach and hypothalamus in model rats (P<0.01), downregulate the mRNA level of GHSR in stomach and upregulate the mRNA levels of 5-HT2bR in stomach and 5-HT2cR in hypothalamus in model rats (P<0.01). Conclusion:Ghrelin is an important material basis of liver-depression, qi-stagnation and blood-stasis; 919 syrup is effective in preventing and treating the syndrome by regulating the abnormal expression of ghrelin in hypothalamus and stomach.
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发布时间：2022-08-31 - 摘要：Objective:To evaluate the effects of Wangshi Ganshu patch on hemorheological indexes and platelet aggregation rate in the rat model of liver-depression and blood-stasis syndrome, and the protective effect for acute liver injury induced by CCl4 in rats. Methods①=1\*GB3Wistar rats were randomly assigned into 5 groups, namely blank control group, liver-depression model group and the Wangshi Ganshu patch low-dose group (crude drug 0.96 g/kg), medium-dose group (1.92 g/kg) and high-dose group (2.88 g/kg), 8 rats in each group. Excluding the blank control group, rat model of liver-depression and blood-stasis was established using the "clip tail" method. Each group of rats was given the corresponding intervention. 14 days later, blood was collected to test the blood viscosity, blood reductive viscosity, erythrocyte rigidity index, erythrocyte deformation index and rate of platelet aggregation. ②=2\*GB3SD rats were randomly assigned into 5 groups, namely blank control group, hepatic injury model group, Wangshi Ganshu patch low-dose group (0.96 g/kg), medium-dose group (1.92 g/kg) and high-dose group (2.88 g/kg), 5 males and 5 females in each group. Excluding the blank control group, CCl4 was used to induce acute hepatic injury model of rats. Each group of rats received corresponding intervention and 14 days later, related biochemical indicators of liver disease were determined. Results:①=1\*GB3Compared with the liver-depression model group, in the high-dose group, increase in the low-cut blood viscosity and blood reductive viscosity, middle-cut blood viscosity and blood reductive viscosity as well as high-cut blood viscosity and blood reductive viscosity was significantly lowered in rat model of liver-depression and blood-stasis (P<0.05); and the erythrocyte rigidity index, erythrocyte deformation index and erythrocyte aggregation rate were reduced significantly (P<0.05). ②=2\*GB3Compared with the liver-depression model group, in the middle-dose and high-dose groups, multiple biochemical indicators of acute liver injury induced by CCl4 were lowered significantly (P<0.05). Conclusion:Wangshi Ganshu patch has certain therapeutic effect in treating diseases with liver-depression and blood-stasis syndrome and shows protective effect on liver damage caused by chemical substances.关键词：Wangshi Ganshu patch;liver-depression and blood-stasis;acute liver injury;rats
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发布时间：2022-08-31 - 摘要：Objective:To explore the protective effect of total flavonoids of Dracocephalum Moldavica L. on hypoxia-induced lung injury in rats. Methods60 SD rats were randomly assigned into the following groups:control group, model group, nifedipine-treated group (NE), and high-dose group (DML.H), medium-dose group (DML.M) and low-dose group (DML.L) of total flavonoids of Dracocephalum Moldavica L. Excluding the control group (10 rats), the model of chronic mountain sickness was established with the other 50 rats. Each group of rats received corresponding intervention. Pulmonary artery pressure, the content of EPO and VEGF in serum, and the content of SOD, MDA and GSH-Px in lung tissues were determined and the pathological changes in lung tissues of rats were observed in each group. Results:Compared with the control group, the pulmonary artery pressure increased, the content of EPO and VEGF in serum increased, the content SOD and GSH-Px in lung tissues decreased, and the content of MDA increased in rats with chronic mountain sickness (P<0.05). Compared with the model group, the pulmonary artery pressure decreased to varying degrees (P<0.05), the content of EPO and VEGF in serum decreased (P<0.05), the content of SOD and GSH-Px in lung tissues increased (P<0.05), and the content of MDA decreased (P<0.05) in the DML.H, DML.M and DML.L groups. Conclusion:The total flavonoids of Dracocephalum Moldavica L. improves pulmonary arterial hypertension caused by hypoxia, reduces oxidative stress and enhances the antioxidant mechanism. It has certain protective effect on lung injury caused by hypoxic environment.关键词：Dracocephalum Moldavuca L;hypoxic environment;lung injury;rats
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发布时间：2022-08-31 - 摘要：This paper reviews the research progress on pharmacological activities of Strychnos nux-vomica L. and methods of synergism and attenuation. Strychnos nux-vomica L. mainly contains alkaloids, which have anti-tumor, anti-inflammatory and analgesic effects, and the effects of regulating immunity, promoting recovery of nerve function, promoting fracture healing, repairing cartilage injury, improving alcohol dependence and regulating small intestinal motility. Strychnos nux-vomica L. is a highly toxic drug, and synergism and attenuation can be achieved by dosage control, preparation, drug compatibility and development of new dosage forms and new manufacturing processes.关键词：Strychnos nux-vomica L.;pharmacological activities;synergism and attenuation;review
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发布时间：2022-08-31 - 摘要：This paper reviews the research progress on inhibiting cardiomyocyte apoptosis by intervention of the mitochondrial pathway with traditional Chinese medicine. Mitochondrial pathway, as a key link in apoptosis, inhibits cardiomyocyte apoptosis by reducing mitochondrial injury, thereby protecting ischemic myocardium. The mitochondrial pathway can be interfered by the monomer of traditional Chinese medicine (saffron acid, resveratrol, etc.) and the traditional Chinese medicine compounds (Jianpi huatan quyu recipe, Gualou xiebai baijiu decoction etc.). In addition to regulating some classical molecules in the mitochondrial apoptosis pathway, it also involves activation of the ROS-mitochondrial pathway, and the mechanism is mostly related to the PI3K/Akt signaling pathway and its downstream molecules including eNOS, GSK-3β and FoxO3a.关键词：traditional Chinese medicine;mechanism;apoptosis;mitochondrial pathway;myocardial ischemia;review
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发布时间：2022-08-31
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