最新刊期
期 2 ， 2019
- 关键词：blood diseases;couplet medicines;clinical experience;Zhou Yuhong
- 7
- |
- 242
- |
- 0
发布时间：2022-08-31 - 关键词：lung cancer;deficiency of essential qi;replenishing qi and nourishing essence;inhibition of cancer and detoxification;famous doctor’s experience;Xu Zhenye
- 7
- |
- 340
- |
- 0
发布时间：2022-08-31 - 关键词：spleen-yin;treatment based on syndrome differentiation;Guishao Liujun Decoction;clinical experience;Yan Xin
- 5
- |
- 246
- |
- 0
发布时间：2022-08-31 - 摘要：This paper discusses the clinical experience of using Maxing Shigan Decoction and modified Sijunzi Decoction in treating eczema. It is considered that the basic etiology and pathogenesis of eczema are spleen deficiency, lung heat and internal accumulation of damp-heat. Therefore, the method of invigorating the spleen and clearing the lung is used to treat the disease. Two proven cases are presented.关键词：eczema;Maxing Shigan Decoction;clinical experience
- 5
- |
- 312
- |
- 0
发布时间：2022-08-31 - 摘要：This paper discusses the application of the method for promoting blood circulation and removing blood stasis in the differentiation and treatment of malignant tumors. The pathological changes of malignant tumor are closely related to the state of blood stasis and the products originated from blood stasis. The method should be used when it is appropriate to the pathogenesis, to the course of disease, to the site of disease and to the pathological products. Physicians should focus on the cause of blood stasis, know the forming time, recognize the site and understand the degree of blood stasis in treating the disease. The prescription of promoting blood circulation should be used to strengthen healthy qi first for treating the root of the disease and be stopped using when it works. Meanwhile, the method of nourishing blood is often used to prevent blood stasis from occurring again.关键词：malignant tumor;blood stasis;promoting blood circulation and removing blood stasis
- 5
- |
- 565
- |
- 0
发布时间：2022-08-31 - 摘要：This paper introduces the unique clinical thinking and experience of Professor Yan Shiyun in the treatment of cardiac disease. In the treatment of the disease, he emphasizes the exuberant and debilitating changes between body healthy qi and pathogenic factors, focuses on qi, blood and the relations among five Zang-organs. The characteristic methods of treating the diseases are mainly regulating yin-yang, especially emotion. The decoctions he prescribed often include pills of Chinese medicines with medicinal paste for consolidating vital root. Professor Yan is flexible in prescribing Chinese medicines and good at using insect drugs, compound prescriptions as well as couplet and group medicines. One proven case is presented.关键词：cardiac diseases;treatment based on understanding the pathogeny;flexible in treating diseases;characteristic of prescription and medicine;famous doctor’s experience;Yan Shiyun
- 7
- |
- 487
- |
- 0
发布时间：2022-08-31 - 摘要：The Basic Functional Specification of TCM Terminology Coding and Terminology Service Platform defines the coding rules of TCM terminology, the logical model of TCM terminology set,the conceptual model of TCM terminology set and the basic functions of TCM terminology service platform. The formulation of TCM terminology set should not only satisfy the characteristics of TCM,such as refining the relationship between terms,reflecting the characteristics of principle-method-recipe-medicines of TCM,and expanding the knowledge of TCM, but also satisfy the relevant characteristics of information,such as coding,indexing,verification, and so on, in order to realize the efficient and accurate query and retrieval function. By constructing and developing, publishing and applying various terminology services, the purpose of the terminology set is to implement the management of the terminology life cycle, accelerate the implementation of related policies, speed up the implementation and application of the relevant standards of TCM and continually improve the terminology set in the application.关键词：TCM terminology set;terminology coding;SNOMED;terminology service;function specification
- 7
- |
- 168
- |
- 0
发布时间：2022-08-31 - 摘要：This paper introduces and comments on the main contents and viewpoints of Modern Chinese Medical History of Qi and Bacteria from three aspects:the breakthrough by the clue from febrile disease, the collision of traditional Chinese and Western medicine on febrile disease, and the thinking caused by febrile disease. The book uses the concept of ‘double-layer of medical history’ to explore the knowledge transformation of exogenous febrile disease of traditional Chinese medicine. It examines the transformation in modern times from the aspects of traditional literature, doctor’s viewpoint, changes of Chinese and Western views on diseases and daily life.关键词：Modern Chinese Medical History of Qi and Bacteria;system of febrile disease;contagious disease;medical history;bacteriology;ideas of body
- 5
- |
- 221
- |
- 0
发布时间：2022-08-31 - 摘要：Objective:To systematically evaluate the efficacy and safety of Guizhi Shaoyao Zhimu Decoction in treating rheumatoid arthritis. MethodsBased on the literature analysis and evaluation method of evidence-based medicine, we searched CNKI, VIP, CBM, Wanfang database and PubMed database, and collected the clinical evidence of Guizhi Shaoyao Zhimu Decoction in the treatment of rheumatoid arthritis with methotrexate (MTX) as control.The quality of the methodology was evaluated, the effective data were extracted,and the RevMan 5.3 software was used to analyze the data by meta analysis. Results:A total of 8 RCTs were included. Meta analysis showed that the total effective rate of Guizhi Shaoyao Zhimu Decoction in the treatment of rheumatoid arthritis (RR=1.17,95% CI) was significantly better than that of MTX. The difference was statistically significant (P<0.01). Guizhi Shaoyao Zhimu Decoction was better than MTX(P<0.01)in shorting the time of morning stiffness, improving grip strength, reducing joint swelling, lowing rheumatoid factor(RF), with the low incidence of adverse reactions (OR=0.20,5%CI, P<0.01). However, there was no significant advantage in reducing joint tenderness and improving ESR compared with MTX. Conclusion:Guizhi Shaoyao Zhimu Decoction has better curative effect on rheumatoid arthritis and the adverse reaction is lower than MTX. However, due to the low quantity and low quality of the literature included, the results of meta analysis were inevitably affected. Therefore, high-quality, large-sample double-blind randomized controlled trials are still needed to provide higher level of evidence.关键词：rheumatoid arthritis;Guizhi Shaoyao Zhimu Decoction;methotrexate;Meta analysis
- 8
- |
- 362
- |
- 0
发布时间：2022-08-31 - 关键词：constitutional theory;image thinking;theoretical construction;classical prescription;Huang Huang
- 6
- |
- 933
- |
- 0
发布时间：2022-08-31 - 摘要：This paper summarizes and analyses the classifications, properties, functions and precautions of the aromatic medicines for invigorating the spleen. The aromatic medicines for invigorating the spleen help recover and improve digestion and absorption of the spleen and stomach, which are classified into four subcategories according to their functional characteristics:the aromatic medicines for resolving dampness and invigorating the spleen; the aromatic medicines for drying dampness and invigorating the spleen; the aromatic medicines for smoothing circulation and invigorating the spleen and the aromatic medicines for warming and invigorating the spleen. The aromatic medicines for resolving dampness and invigorating the spleen include Herba Agastaches, Herba Eupatorii, etc; The aromatic medicine for drying dampness and invigorating the spleen include Fructus Tsaoko,Semen Alpiniae Katsumadai and so on; The aromatic medicine for smoothing circulation and invigorating the spleen include Pericarpium Citri Reticula, Radix Aucklandiae,etc; The aromatic medicine for warming and invigorating the spleen include Semen Myristicae,Fructus Evodiae, etc.关键词：aromatic medicines for invigorating the spleen;properties;functions;classify
- 5
- |
- 479
- |
- 0
发布时间：2022-08-31 - 摘要：This article summarizes the application of Radix Aucklandiae in Complete Effective Prescriptions for Diseases of Women. Radix Aucklandiae is the most commonly used ingredient in the prescriptions of the book. Chen Ziming used it not only regulating qi and stopping diarrhea, but also awakening the spleen, resolving depression, treating malnutritional stagnation, regulating menstruation,dissipating blood stasis and so on.关键词：Complete Effective Prescriptions for Diseases of Women;qi-regulating medicine;Radix Aucklandiae;efficacy
- 4
- |
- 444
- |
- 0
发布时间：2022-08-31 - 摘要：Objective:To observe and objectively evaluate the clinical efficacy of milli-fire needle in the treatment of knee osteoarthritis of cold-dampness blockage type complicated with synovitis by musculoskeletal ultrasound. Methods60 patients with knee osteoarthritis of cold-dampness blockage type complicated with synovitis were assigned into the treatment group and the control group according to the random number table, 30 patients in each group. Patients in the treatment group were treated with milli-fire needle plus TDP irradiation, while those in the control group received simply acupuncture plus TDP irradiation. Patients in both groups were treated for 2 weeks. Synovial thickness and joint effusion depth in the knee joint were observed based on musculoskeletal ultrasound and the changes in VAS pain score, WOMAC score and knee joint circumference were compared. Results:① There were statistically significant differences in synovial thickness and joint effusion depth in both groups before and after treatment (P<0.05). After treatment, there were statistically significant differences in synovial thickness and joint effusion depth between the groups, and improvement in the treatment group was significantly superior to that in the control group (P<0.05). ② There were statistically significant differences in VAS pain score and WOMAC score in both groups before and after treatment (P<0.05). After treatment, there were statistically significant differences in VAS pain score and WOMAC score between the groups, and the scores were significantly lower in the treatment group than in the control group (P<0.05). ③ There was statistically significant difference in knee joint circumference in both groups before and after treatment (P<0.05). After treatment, there was statistically significant difference in knee joint circumference between the groups, and the circumference was significantly smaller in the treatment group than in the control group (P<0.05). Conclusion:Compared with simply acupuncture, milli-fire needle shows a better clinical efficacy in the treatment of knee osteoarthritis of cold-dampness blockage type complicated by synovitis. It effectively relieves the pain of patients, reduces knee joint swelling, improves synovial lesions, and reduces joint effusion.关键词：knee osteoarthritis;synovitis;cold-dampness blockage syndrome;milli-fire needle;musculoskeletal ultrasound
- 5
- |
- 626
- |
- 0
发布时间：2022-08-31 - 摘要：Objective:To observe the distribution characteristics of knee nodal points in patients with knee osteoarthritis (KOA) of the anemofrigid-damp arthralgia type and the effect of Duhuo Jisheng Decoction combined with manipulation of the nodal points. Methods80 patients with KOA of the anemofrigid-damp arthralgia type were randomly assigned into the treatment group and the control group, 40 patients in each group. Patients in the control group were treated with western medicine, and those in the treatment group received Duhuo Jisheng Decoction combined with manipulation of the nodal points in addition. Patients in both groups were treated for 4 weeks and followed up for 8 weeks. The nodal points were examined by palpitation before treatment, and the degree of tenderness was scored. The changes in scores on the Western Ontario and McMaster Universities (WOMAC) osteoarthritis scale and scores in the five-times-sit-to-stand test (FTSST) were observed. Results:① 78 subjects completed the trial, including 38 in the treatment group and 40 in the control group. ② By palpation, it was found that 92.5% of patients with KOA of the anemofrigid-damp arthralgia type had nodal points around the knee, mainly distributed in the medial knee joint, such as medial depression of patellar ligament, pes anserinus, adductor tubercle and medial collateral ligament; and in the lateral knee joint, it is mainly distributed in the depression on the outside of the knee. Overall, there were obviously more nodal points in the medial knee than in the lateral knee, and the degree of tenderness in the medial knee was also significantly higher than that in the lateral knee. ③ The scores of pain, stiffness and joint function and the total score deceased significantly in the treatment group after treatment compared to those before treatment and at 8 weeks of follow up compared to those before treatment; and except for the stiffness score, the other scores decreased significantly in the control group (P<0.05). The pain score showed a tendency of decline in the treatment group, and the other scores showed a tendency of increase to varying degrees at 8 weeks of follow up compared to those after treatment, but there were no statistically significant differences (P>0.05); and the scores of pain and joint function and the total score increased significantly in the control group (P<0.05). There were significant differences in the scores of pain, stiffness and joint function and the total score between the groups after treatment and at 8 weeks of follow up, and the scores were significantly lower in the treatment group than in the control group (P<0.05). ④ The FTSST score decreased significantly in both groups after treatment compared to that before treatment and at 8 weeks of follow up compared to that before treatment (P<0.05); and the FTSST score increased significantly in the control group at 8 weeks of follow up compared to that after treatment (P<0.05). The FTSST score was significantly lower in the treatment group than in the control group after treatment and at 8 weeks of follow up (P<0.05). Conclusion:Compared to treatment with western medicine, treatment with western medicine plus manipulation of the nodal points and Duhuo Jisheng Decoction is more effective in treating KOA of the anemofrigid-damp arthralgia type and it significantly improves the pain, stiffness and function of the knee with stable treatment effect.关键词：knee osteoarthritis;anemofrigid-damp arthralgia syndrome;nodal points;manipulation maneuver;Duhuo Jisheng Decoction
- 9
- |
- 264
- |
- 0
发布时间：2022-08-31 - 摘要：Objective:To observe the clinical efficacy of Qinjiang Baoling Decoction in the treatment of non-alcoholic fatty liver disease (NAFLD) of phlegm-blood stasis type. Methods100 patients with NAFLD of phlegm-blood stasis type were randomly assigned into the treatment group and the control group, 50 patients in each group. Diet control, exercise therapy and symptomatic treatment including lowering blood fat and sugar were prescribed to patients in the control group and patients in the treatment group received Qinjiang Baoling Decoction in addition. Patients in the two groups were treated for 3 months and then followed up for 3 months. The clinical efficacy was observed, and the changes in TCM syndrome score, liver function [alanine transferase (ALT) and γ-glutamamide transferase (γ-GT)], blood fat [total cholesterol (TC) and high density lipoprotein (HDL-C)], body mass index (BMI), insulin resistance index (HOMA-IR), score of abdomen B-mode ultrasound and liver/spleen CT ratio were compared between the groups. Results:① At 3 months after treatment, the total effective rate was 64.0% and 52.0% in the treatment group and the control group respectively, and the clinical efficacy in the treatment group was superior to that in the control group (P<0.05). ② The scores of hypochondriac pain, fullness and rigidity, fullness of the chest and epigastrium, swollen eyes and bitter taste in the mouth, and waist soreness and limb heaviness decreased significantly in the groups after treatment compared to those before treatment (P<0.05); and at 3 months after treatment, there were statistically significant differences in the scores of hypochondriac pain, fullness of the chest and epigastrium and waist soreness and limb heaviness between the groups (P<0.05). ③ The levels of ALT, γ-GT and TC in serum decreased significantly in the groups after treatment compared to those before treatment (P<0.05); and at 3 months after treatment, the levels of ALT, γ-GT and TC in serum were lower in the treatment group than in the control group (P<0.05). ④ In the treatment group, the values of BMI and HOMA-IR decreased after treatment compared to those before treatment (P<0.05); and there were no statistically significant differences in the control group (P>0.05). ⑤ In the treatment group, there were statistically significant differences in the scores of abdomen B-mode ultrasound and liver/spleen CT ratio before and after treatment (P<0.05); and there was only statistically significant difference in the score of abdomen B-mode ultrasound in the control group (P<0.05). At 3 months after treatment, there were statistically significant differences in the score of abdomen B-mode ultrasound and liver/spleen CT ratio between the groups (P<0.05). Conclusion:Qinjiang Baoling Decoction shows satisfactory efficacy in the treatment of NAFLD of phlegm-blood stasis type. It improves the clinical symptoms, regulates liver function and the level of blood fat, inhibits insulin resistance and promotes recovery of liver morphology with sustained effects.关键词：non-alcoholic fatty liver disease;phlegm-blood stasis;therapy in traditional Chinese medicine;Qinjiang Baoling Decoction;liver function;blood fat
- 5
- |
- 137
- |
- 0
发布时间：2022-08-31 - 摘要：Objective:To observe the effects of Erbai Decoction combined with amlodipine besylate on morning blood pressure surge in patients with hypertension. Methods72 patients with hypertension were randomly assigned into the treatment group and the control group, 36 patients in each group. Oral amlodipine besylate was given to patients in both groups and patients in the treatment group received Erbai Decoction in addition. The duration of treatment was 28 days in both groups. The 24h mean systolic blood pressure (SBP), 24h mean diastolic blood pressure (DBP), 24h control rate of blood pressure, control rate of morning blood pressure surge and changes in scores on the modified SPIEGEL sleep scale were observed. Results:①After treatment, 24h mean SBP and DBP decreased significantly in the groups (P<0.05), but with no statistically significant difference between the groups (P>0.05). ②There were statistically significant differences in values of morning blood pressure surge and scores on the SPIEGEL sleep scale in the groups before and after treatment (P<0.05); and there were statistically significant differences in values of morning blood pressure surge and scores on the SPIEGEL sleep scale (P<0.05) between the groups after treatment (P<0.05). ③The 24h control rate of blood pressure and control rate of morning blood pressure surge were 88.9% and 91.7% respectively in the treatment group, and were 67.7% and 44.4% respectively in the control group, with the treatment group significantly superior to the control group (P<0.05). Conclusion:The observation results indicate that Erbai Decoction combined with amlodipine besylate has definite efficacy in the treatment of hypertension, as the 24h ambulatory blood pressure and morning blood pressure surge are well controlled, and the quality of sleep is improved remarkably.关键词：hypertension;morning blood pressure surge;Erbai Decoction;ambulatory blood pressure;sleep disorders
- 5
- |
- 121
- |
- 0
发布时间：2022-08-31 - 摘要：Objective:To observe the clinical efficacy in acupuncture treatment of refractory gastroesophageal reflux disease (GERD) by needling the dorsal segment of Governor Vessel below the spinous processes from T3 to T12. Methods60 patients with gastroesophageal reflux disease were randomly assigned into the acupuncture group and the medication group, 30 patients in each group. Esomeprazole magnesium enteric-coated tablets were administrated to patients in the medication group and in the acupuncture group, the dorsal segment of Governor Vessel below the spinous processes from T3 to T12 was punctured. Duration of treatment was 8 weeks in both groups. Clinical efficacy was observed, and the changes in scores of RDQ (Gerd Questionnaire) and GERD-HRQL and in the threshold of tenderness below the spinous processes from T3 to T12were compared. Results:① The markedly effective rate was 60.0% and 26.7% in the medication group and the acupuncture group; and it was superior in the acupuncture group to that in the medication group (P<0.05). ② The RDQ and GERD-HRQL scores decreased significantly in both groups after treatment compared to those before treatment (P<0.05); and the scores were lower in the acupuncture group than in the medication group after treatment (P<0.05). ③ In the acupuncture group, the threshold of tenderness below the spinous processes from T3 to T12 increased significantly (P<0.05), while it decreased significantly in the medication group (P<0.05) after treatment compared to that before treatment; and there was significant difference in the threshold between the groups after treatment (P<0.05). Conclusion:There is satisfactory clinical efficacy in acupuncture treatment for refractory gastroesophageal reflux disease by needling the dorsal segment of Governor Vessel below the spinous processes from T3 to T12, and acupuncture alleviates patients’ clinical symptoms and improves their quality of life more effectively than esomeprazole magnesium enteric-coated tablets.关键词：refractory gastroesophageal reflux disease;acupuncture;dorsal segment of Governor Vessel;below the spinous processes;tenderness;clinical study
- 5
- |
- 333
- |
- 0
发布时间：2022-08-31 - 摘要：Objective:To observe the expression of IL-15 and IL-22 in decidua and peripheral blood and the effect of Bushen Huoxue Recipe on it in patients with unexplained recurrent spontaneous abortion (URSA). MethodsTrial 1:30 patients were enrolled and assigned into the experimental group (patients with URSA and pregnancy failure) and the normal control group (patients with normal pregnancy and induced abortion), 15 patients in each group; and the mRNA levels of IL-15R and IL-22R in decidual tissues of the subjects in the two groups were determined by RT-PCR. Trial 2:60 patients with URSA and re-pregnancy were randomly assigned into the treatment group and the control group, 30 patients in each group; and the treatment group was treated with Bushen Huoxue Recipe + dydrogesterone, while the control group was treated with dydrogesterone. Both groups were treated for 4 weeks, and the short-term efficacy and pregnancy outcome were observed. Changes in the levels of IL-15 and IL-22 in peripheral blood were compared. Results:① RT-PCR showed that the expression of IL-15R and IL-22R in decidual tissues of subjects in the experimental group was significantly higher than that in the normal control group (P<0.05). ② There was no significant difference in the levels of IL-15 and IL-22 between the groups before treatment (P>0.05). The levels decreased significantly in both groups before and after treatment (P>0.05). After treatment, the levels were significantly lower in the treatment group than in the control group (P<0.05). ③ The total effective rate was 93.33% and 73.33% in the treatment group and the control group respectively; and the short-term efficacy in the treatment group was significantly superior to that in the control group (P<0.05). ④ The abortion rate was 6.67% and 26.67% in the treatment group and the control group respectively. It was significantly lower in the treatment group than in the control group (P<0.05). Conclusion:The occurrence of URSA may be related to the high expression of IL-15R and IL-22R in the decidua. At the same time, Bushen Huoxue Recipe significantly down-regulates the levels of IL-15 and IL-22 in peripheral blood of patients with URSA. The mechanism of action may be regulation of maternal immune tolerance during pregnancy, thereby facilitating maintenance of pregnancy and reducing the incidence of abortion.关键词：unexplained recurrent spontaneous abortion;Bushen Huoxue Recipe;decidua;peripheral blood;IL-15;IL-22;immune tolerance
- 7
- |
- 224
- |
- 0
发布时间：2022-08-31 - 摘要：Objective:To observe the cardioprotective effect of Kuoxinfang on tnnt2a mutant zebrafish model with similar phenotype to dilated cardiomyopathy and explore the possible mechanism of action. MethodsThe normal wild-type zebrafish were used in the control group, the tnnt2a mutant zebrafish were used in the model group and the tnnt2a mutant zebrafish that received Kuoxinfang 5 μg/ml were used in the Kuoxinfang group. The effect of Kuoxinfang on tnnt2a mutant zebrafish was studied and the survival rate, sinus venosus-bulbus arteriosus (SV-BA) distance, HE staining of pathological sections, ATP content and expression of the apoptosis-related gene bcl-2/bax were observed. Results:Compared to the model group, Kuoxinfang has protective effect on the heart of tnnt2a mutant zebrafish, as it improves the survival rate, increases the ATP content and upregulates expression of the bcl-2/bax gene in zebrafish of the model group (P<0.05, P<0.01). Conclusion:Kuoxinfang shows cardioprotective effect in the tnnt2a mutant zebrafish model, and the mechanism may be associated with improvement in energy metabolism and reduction in apoptosis of cardiomyocytes.关键词：dilated cardiomyopathy;zebrafish;Kuoxinfang;cardioprotection
- 5
- |
- 243
- |
- 0
发布时间：2022-08-31 - 摘要：Objective:To investigate the inhibitory effect of Baihe Recipe on growth and metastasis of orthotopically transplanted human gastric carcinoma BGC-823 in nude mice and the effects on microvascular density (MVD) and the expression of matrix metalloproteinases-9 (MMP-9) in the tumor tissues. MethodsSixty nude mice orthotopically transplanted with human gastric cancer BGC-823 cells were randomly assigned into four groups:Baihe recipe group, 5-fluorourcil (5-FU) group, Baihe recipe + 5-FU group and model group, 15 mice in each group. The Baihe recipe group received Baihe recipe 0.5 ml (0.2 g/ml) by gastric gavage once a day, the 5-FU group was intraperitoneally administered 5-Fu dilution 0.2 ml (6 mg/ml) once a week, the Baihe recipe + 5-FU group was administered Baihe recipe 0.5 ml (0.2 g/ml) by gastric gavage once a day and 5-FU dilution 0.2 ml (6 mg/ml) intraperitoneally once a week, and the untreated group was given 0.9% NaCl solution 0.5 ml by gastric gavege once a day. When the experiment was completed at 6 weeks after administration, the growth and metastasis of the orthotopically transplanted tumor in nude mice was observed and tumor mass was measured to calculate the tumor inhibition rate in each group. The ultrastructure was observed under electron microscopy. MVD and the expression of MMP-9 were detected in the tumor tissues by immunohistochemistry in each group. Results:The tumor mass was obviously lower in the Baihe recipe, the 5-FU and the Baihe recipe + 5-FU groups than in the model group, with an inhibition rate of 48.65%, 47.64% and 54.39% respectively. Under electron microscope, the gastric cancer cells showed apoptosis in the Baihe recipe, the 5-FU and the Baihe recipe + 5-FU groups. MVD and the expression of MMP-9 in the tumor tissues decreased in the Baihe recipe and the Baihe recipe + 5-FU groups compared to the 5-FU and the model groups (P<0.05). Conclusion:Baihe recipe inhibits the growth and metastasis of human gastric cancer BGC-823 orthotopically transplanted in nude mice, reduces MVD and inhibits microangiogenesis in the tumor tissues, probably by down-regulating the expression of MMP-9.关键词：stomach neoplasms;nude mice;Baihe recipe;microvascular density;matrix metalloproteinases-9
- 5
- |
- 166
- |
- 0
发布时间：2022-08-31 - 摘要：Objective:To investigate the regulatory effect of Chinese herbal compound for invigorating the kidney and removing dampness on the NALP6 signaling pathway in rats with gouty arthritis (GA). MethodsEighty-four SD rats were randomly assigned into the blank control group, model group, tongfengshu group, colchicine group, low-dose Chinese medicine group, medium-dose Chinese Medicine group and high-dose Chinese Medicine group. Gavage administration was performed once daily. At 1h after administration on day 7, the modified composite modeling method with potassium oxazinate and sodium urate was used to establish the GA rat model. Samples were collected at 4h after modeling, the pathological changes in synovial tissues were observed in rats of each group, the content of uric acid, caspase-1, IL-1β and IL-18 in serum was determined by ELISA and the expression level of NALP6 in synovial tissues was detected by Western blot. Results:In the medium-dose Chinese medicine group treated with Chinese herbal compound for invigorating the kidney and removing dampness, the pathological changes in synovial tissues, the value of blood uric acid in the body, and the expression levels of caspase-1, IL-1β and IL-18 in serum decreased significantly compared to the model group (P<0.05); and in the high-dose Chinese medicine group treated with the Chinese herbal compound, Western blot analysis showed that the expression level of NALP6 decreased significantly in synovial tissues compared to the model group (P<0.05). Conclusion:Blocking the inflammatory signaling pathway of “NALP6-caspase-1-IL-1β” is an important mechanism of action in preventing and treating gouty arthritis with Chinese herbal compound for invigorating the kidney and removing dampness.关键词：invigorating the kidney and removing dampness;gouty arthritis;NALP6;rats
- 5
- |
- 327
- |
- 0
发布时间：2022-08-31 - 摘要：Objective:To study the effects on body mass and blood leptin in offspring after intervention of mice under postpartum immobilization stress with Huganfang 919 syrup. MethodsThe postpartum female mice were randomly assigned into the control group, the immobilization stress (IS) group and the 919 syrup treatment group. At the time of IS, the 919 syrup treatment group was administered 919 syrup by gastric gavage daily (27 g·kg-1·d-1), the IS group was given an equal dose of 0.9% NaCl solution and the control group received no treatment. At weaning 3 weeks later, changes in the body mass, blood leptin and Ob-Rb mRNA in the liver were observed in the offspring. Results:Compared to the control group, decreased body mass was observed in the IS and the 919 syrup treatment groups at 6,3, 18 and 23 weeks of age, with statistically significant difference (P<0.05); and there was no statistically significant difference in body mass between the IS and the 919 syrup treatment groups (P>0.05). At 23 weeks of age, the level of plasma leptin increased in the IS group compared to the control group, while it decreased in the 919 syrup treatment group compared to the IS group, both with statistically significant difference (P<0.01). At 23 weeks of age, the relative expression of Ob-Rb mRNA in the liver increased significantly in the IS group compared to the control group, (P<0.01), while it decreased significantly in the 919 syrup treatment group compared to the IS group (P<0.05); and there was no significant difference in the male offspring among the three groups (P>0.05). Conclusion:The low body mass caused by postpartum IS is associated with leptin, and Huganfang 919 syrup improves the changes in leptin by regulating OB-Rb mRNA in the liver.关键词：postpartum immobilization stress;mice;919 syrup;plasma leptin
- 5
- |
- 91
- |
- 0
发布时间：2022-08-31 - 摘要：Objective:To study the improvement in quality standard of Scutellariae Radix slices using the drug prepared from Scutellaria baicalensis Georgi in the production place as the study subject. MethodsThe content of baicalin, wogonoside, baicalein, wogonin and oroxylin A was determined in 10 batches of samples using a method established with HPLC, and the content of moisture, total ash and extracts was also determined. Results:The method for content determination was simple, accurate and reproducible, and there were slight differences in the content of moisture, total ash and extracts among different batches of samples. Conclusion:A relatively perfect quality standard has been established for baicalus scutellariae slices, which is considerably improved compared to the standard in Chinese Pharmacopoeia of the 2015 edition, and can be used to effectively control the quality of the slices.关键词：Scutellariae Radix slices;content determination;quality standard;HPLC
- 7
- |
- 573
- |
- 0
发布时间：2022-08-31 - 摘要：This article is a review of the pharmacological effects of Dendrobium nobile Lindl.alkaloids(DNLA). DNLA is the main active ingredient of Dendrobium nobile Lindl., and has pharmacological effects such as anti-cataract,anti-tumor,neuroprotection,hypoglycemic,hypolipidemic and anti-oxidation.关键词：Dendrobium nobile Lindl;alkaloids;dendrobine;pharmacologic action;review
- 1
- |
- 247
- |
- 0
发布时间：2022-08-31 - 摘要：This paper reviews the progress of anti-inflammatory and immune effects of the alkaloids extracted from Peganum harmala. The chemical constituents of Peganum are mainly alkaloids, which have the following functions:DNA topoisomerase activity and cytotoxicity; immunity to lymphocytes and cytokines; anti-inflammatory and analgesic effects.关键词：Peganum harmala;alkaloids;immunity;anti-inflammatory;analgesia;cytotoxicity;pharmacological effects;review
- 1
- |
- 315
- |
- 0
发布时间：2022-08-31
- Technical support is provided by Beijing Founder electronics co., LTD 沪ICP备13044091号
沪公网安备 31011502015228号 - It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
- Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.
- Total Visits：70575 Visits Today：56
0