最新刊期
期 11 ， 2019
- 摘要：This paper introduces Professor Zhou Yuhong’s experience in the treatment of chronic lymphoid leukemia by stages. It is considered that the disease is related to the liver, spleen and kidney, which can be divided into early stage (pattern of qi stagnation and phlegm coagulation), middle stage (pattern of phlegm stagnation and toxin accumulation) and end stage (pattern of essence and marrow deficiency). Based on the principle of “strengthening healthy qi to eliminate pathogenic factors”, Professor Zhou treated the disease with the methods of resolving phlegm to dissipate stagnation and raising healthy qi in the early stage, eliminating toxic materials to disperse accumulation and invigorating qi to nourish yin in the middle stage, and supplementing essence to replenish marrow and removing toxic materials at the end stage. During the treatment, the middle Jiao should be protected and the attacking method should be stopped at the right time.关键词：chronic lymphoblastic leukemia;treatment by stage;clinical experience
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发布时间：2022-08-31 - 摘要：Zha Weimin is very good at treating difficult miscellaneous diseases,such as chronic gastritis complicated with oral lichen planus treated with the methods of soothing the liver and harmonizing the stomach and clearing away heat,invigorating the spleen and supplementing qi and nourishing yin; Henoch-Schonlein purpura nephritis complicated with chronic gastritis treated with the methods of invigorating qi and nourishing yin,dredging the collaterals and detoxify ; meniscus injury complicated with fasciitis and tennis elbow treated with the methods of nourishing the liver and kidney,invigorating the spleen to eliminate dampness,dispel the wind and dredging the collaterals; systemic lupus erythematosus complicated with postherpetic neuralgia treated with the methods of clearing away heat and promoting diuresis,activating blood circulation and detoxify,strengthening healthy qi to consolidate body resistance . Four cases of difficult miscellaneous diseases treated by Zha Weimin with the methods of treating different diseases with the same therapy were analyzed.关键词：Zha Weimin;difficult miscellaneous diseases;expertise;medical cases
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发布时间：2022-08-31 - 摘要：This paper introduces the clinical experience of Professor Liu Lumin in the treatment of pancreatic cancer ascites with integrated Chinese and Western medicine, and provides a new thought for the treatment of the disease. Professor Liu has three main characteristics in the treatment of pancreatic cancer ascites: the use of Binglang(Semen Arecate) to promote qi flow and excrete water, the use of integrated traditional Chinese and Western medicine to promote diuresis, and the simultaneous use of internal and external treatment to suppress cancer and eliminate water. Combined application of the three methods can often achieve good results.关键词：pancreatic cancer;ascites;integrated Chinese and Western medicine therapy;umbilicus-applying therapy;experience of famous doctor
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发布时间：2022-08-31 - 摘要：By reviewing the relevant literature, especially the consensus opinions on the diagnosis and treatment of gastroesophageal reflux disease (GERD) in Chinese medicine in recent years, and combining with my experience in clinical practice, this paper discusses the Expert Consensus on Diagnosis and Treatment of Gastroesophageal Reflux Disease in Traditional Chinese Medicine (2017) from six aspects, i.e. disease name, pathogenesis, diagnosis, pattern identification, treatment goal, and treatment process. It is suggested that Chinese medicine should also use “gastroesophageal reflux disease” as a unified disease name. It is particularly important to correctly understand the mechanism of acid reflux. It is also suggested that the role of experimental treatment of traditional Chinese medicine and acupoint detection in the diagnosis of GERD should be brought into play. In treatment, it is of the first thing to distinguish whether there are typical reflux symptoms, and then to combine with other symptoms and signs of the tongue and pulse to identify patterns. Treating the reflux should be used as the essential strategy and root treatment as the primary therapeutic principle. At the same time, the flow chart of diagnosis and treatment of GERD in Chinese medicine was redefined to provide help and reference for clinical diagnosis and treatment of this disease.关键词：gastroesophageal reflux disease;consensus;traditional Chinese medicine;acupuncture;diagnosis and treatment process
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发布时间：2022-08-31 - 摘要：Drug screening and pathological mechanism of acute liver injury depend largely on the establishment and application of experimental animal models. In this paper,five common animal models of acute liver injury,including CCl4,ANIT,DDC,D-GalN/LPS and APAP,were selected and discussed in detail from the aspects of model preparation,biochemical characteristics,pathological mechanism,advantages/disadvantages,application of traditional Chinese medicine pharmacological research,etc.,which is of great significance for the prevention and treatment of acute liver injury.关键词：acute liver injury;animal models;traditional Chinese medicine pharmacology;research strategies
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发布时间：2022-08-31 - 摘要：Objective:To study the current status of domestic patent application of Chinese medicine compound for anti-colorectal cancer in the past 10 years, and explore the drug use and compatibility rules in the patent compound. MethodsThrough the patent search system of the State Intellectual Property Office and the SooPat patent search engine, the common search and classified search were used to search the patent application of Chinese medicine compound for anti-colorectal cancer in the database by using “colorectal cancer (rectal cancer, colon cancer)”, “intestinal tumor” and “Chinese medicine” as keywords. Relevant analysis was carried out after the establishment of patent database of Chinese medicine compound, statistics of its application amount, legal status, application area, application subject, and medication status. Results:①Overall, the patent for the enrolled Chinese medicine compound (5.70%) was still relatively small. From 2014, the application for the patent of Chinese medicine compound for anti-colorectal cancer clearly showed an active trend. ②The total number of patent applications of Chinese medicine compound for anti-colorectal cancer in Shandong Province far exceeded that of other provinces and cities, accounting for 35.44% of the total number of applications. ③In the patent application of the Chinese medicine compound for anti-colorectal cancer, the individual occupied the majority, and the enterprise company was also one of the main research and development for the patent of Chinese medicine compound. ④In the patent application of Chinese medicine compound for anti-colorectal cancer, only 3 items referred to specific types of syndromes, accounting for only 2% of all patents. ⑤The prescriptions of the patent compound of Chinese medicine for anti-colorectal cancer was mainly based on current prescriptions with lots of Chinese medicine; the most frequently used Chinese medicine in the compound was Baihua Sheshecao (Herba Hedyotis Diffusae), Huangqi(Radix Astragali), followed by Banzhilian (Herba Portulacae Grandiflorae), Fuling (Poria), Baizhu (Rhizoma atractylodis Macrocephalae), etc. Among the medicines, most of them were attributive to the spleen and stomach meridians. The therapeutic principle was mainly to clear away heat and remove toxic materials, replenish qi and strengthen healthy qi, strengthen the spleen and eliminate dampness, and the herbs were mostly bitter in flavor and cold in nature, accompanied by the herbs sweet in flavor and warm in nature. ⑥The most commonly used couplet medicines were Baihua Sheshecao (Herba Hedyotis Diffusae) -Banzhilian (Herba Portulacae Grandiflorae), Huangqi(Radix Astragali) -Banzhilian(Herba Portulacae Grandiflorae), Fuling(Poria) -Baizhu(Rhizoma atractylodis Macrocephalae), Huangqi(Radix Astragali) -Ezhu (Rhizoma Curcumae) and so on. Conclusion:In the past 10 years, the number of patent applications of Chinese medicine compound for anti-colorectal cancer has increased year by year, but there are still problems to be overcome, such as the improvement of clinical and experimental research evidence, the combination of TCM syndrome types and compound patents, etc. The main idea of medication is to clear away heat and remove toxic materials, replenish qi and strengthen healthy qi, strengthen the spleen and eliminate dampness, and the Chinese medicine with the function of activating blood circulation to resolve stasis also has certain potential in patent research and development.关键词：intestinal cancer;Chinese medicine compound;patent application;rule of medication;therapeutic principle and method;couplet medicines
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发布时间：2022-08-31 - 摘要：Objective: To evaluate the efficacy and safety of Wenxin granule combined with Western medicine in the treatment of atrial fibrillation. Methods Six mainstream Chinese and English databases including Pubmed,Embase,Cochrane,Chinese biological literature database,CNKI,and Wanfang were searched and collected for systematic reviews on the treatment of atrial fibrillation by using the method of overview of systematic review. Based on the methodological quality appraisal tool AMSTAR 2 and reporting checklist PRISMA statement, the methodological quality and the reporting quality of the included systematic reviews were assessed respectively. A qualitative analysis was conducted to evaluate the efficacy and safety of Wenxin granule combined with Western medicine for atrial fibrillation on the cardioversion rate, the recurrence rate, the maintenance rate of sinus rhythm, the frequency of atrial fibrillation, the improvement of the ventricular rate. Results:①A total of 11 systematic evaluations were included,and the median of the original studies included in the 11 literatures was 24. ②The overall methodological quality of the included system evaluations was extremely low,as assessed by the AMSTR 2 tool. The highest score of the 11 systematic evaluations by AMSTAR2 is 9,the lowest is 3.5,and the average score is 6.0. ③There were also some defects in the quality of the 11 systematic reports.The highest PRISMA score was 23.0,the lowest 15.0,and the average score was 19.8. ④Qualitative analysis showed that Wenxin granule combined with Western medicine was more effective and safer than Western medicine alone on cardioversion rate, recurrence rate and maintenance rate of sinus rhythm. But the clinical efficacy was limited in terms of ventricular rate and frequency of atrial fibrillation. In addition,due to the low quality of methodology included in the systematic evaluation and the low quality of relevant evidence,there may be variations in clinical use of the medicine. Conclusion: The current evidence showed that Wenxin granule combined with Western medicine may have better effect for atrial fibrillation. However, at present, the methodological quality of the corresponding systematic evaluation is low, and the quality of the curative effect evidence is also low, the guiding value for clinical use of the medicine is limited. Therefore, it is suggested that Wenxin granule can only be used as an auxiliary drug for patients with non-valvular paroxysmal atrial fibrillation. It seems that more high quality and well-designed RCT are still needed to evaluate the efficacy and safety of Wenxin granule for atrial fibrillation.关键词：atrial fibrillation;Wenxin granule;overview of systematic review
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发布时间：2022-08-31 - 摘要：Acute urticaria usually appears as sthenia-heat syndrome, but quite a few of them are shown as asthenia-cold syndromes. Under the guidance of the theory of exterier syndrome of Shaoyin and the principle of warming yang to relieve exterior syndrome,the disease was treated with the prescriptions of modified Mahuang Fuzi Xixin Docoction, Mahuang Fuzi Gancao Docoction and so on. The experience is introduced on the diagnosis and treatment of acute urticaria from exterior syndrome of Shaoyin. And two proven cases are presented.关键词：acute urticaria;exterior syndrome of Shaoyin;warming yang to relieve exterior syndrome
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发布时间：2022-08-31 - 摘要：The clearing method in the six channels and nine differentiation methods is divided into the methods of dissipating heat with herbs cool in nature, dissipating heat with herbs cold in nature and saving yin. The clearing method is expounded respectively from aspects of the main points of diagnosis and treatment, treatment method and prescription and its evolution in later generations. The corresponding basic prescriptions, analogical prescriptions and modified prescriptions are summarized.关键词：six channels and nine differentiation methods;dissipating heat method with herbs cool in nature in Taiyang channel;dissipating heat method with herbs cold in nature in Yangming channel;saving yin method in Shaoyin channel;main points of diagnosis and treatment;modified prescriptions
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发布时间：2022-08-31 - 摘要：Objective:To observe the efficacy and safety of Yangxue Ruanjian capsule in the treatment of knee osteoarthritis. MethodsIn this randomized, double-blind, placebo-controlled study, 84 patients with knee osteoarthritis were randomly assigned into control group and treatment group, 42 patients in each group. The treatment group was given Yangxue Ruanjian capsule and the control group received placebo. The treatment course was 4 weeks in both groups. The changes in TCM syndrome score and the total score, pain sub-score, stiffness sub-score and joint function sub-score of Western Ontario and McMaster Osteoarthritis Index (WOMAC) were observed and safety was evaluated before treatment and at 2 and 4 weeks of treatment. Results:①All of the 84 patients completed the visit at 2 weeks of treatment; at 4 weeks of treatment, there were 6 and 7 dropouts (lost to follow-up) in the treatment group and the control groups, respectively. ②There were no significant differences in WOMAC total score or sub-scores in the groups before treatment and at 2 weeks of treatment (P＞0.05). At 4 weeks of treatment, WOMAC total score and sub-scores decreased compared to those before treatment in the treatment group (P＜0.05), and WOMAC total score, pain sub-score and joint function sub-score decreased in the control group (P＜0.05).③There were greater differences in WOMAC total scores and sub-scores in the treatment group than in the control group at 2 vs. 4 weeks of treatment and before treatment vs. at 4 weeks of treatment (P＜0.05). ④The TCM syndrome score decreased in both groups before treatment vs. at 2 and 4 weeks of treatment (P＜0.05). There were no significant differences in TCM syndrome score at any time point between the groups (P＞0.05). Conclusion:Yangxue Ruanjian capsule effectively relieves the symptoms of patients with knee osteoarthritis with good safety, including joint pain, stiffness and dysfunction, showing the value for further research and development.关键词：knee osteoarthritis;Yangxue Ruanjian capsule;randomized controlled;placebo
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发布时间：2022-08-31 - 摘要：Objective:To observe the clinical efficacy of Yanghe Yifei decoction combined with Western medicine in the treatment of pulmonary fibrosis of the lung-kidney yang deficiency type. MethodsEighty patients with pulmonary fibrosis due to deficiency of lung and kidney yang were randomly assigned into treatment group and control group, 40 patients in each group. The control group was given oxygen, oral methylprednisolone and acetylcysteine, while the treatment group was given Yanghe Yifei decoction in addition. The two groups were treated for 3 months. The clinical efficacy was observed and the changes in symptom and sign score, HRCT score, lung function and serum levels of transforming growth factor-β1 (TGF-β1), interferon-γ (IFN-γ) and interleukin-17 (IL-17) were compared. Results:①The total effective rate was 90.0% and 80.0% in the treatment group and the control group, respectively. The clinical efficacy was superior in the treatment group to that in the control group (P<0.05). ②There were significant differences in asthma, cough, expectoration, Velcro rale and HRCT scores in both groups before and after treatment (P<0.05); there were significant differences in asthma, cough and HRCT scores between the two groups after treatment (P<0.05). ③Vital capacity (VC) was improved in the treatment group after treatment (P<0.05); there was significant difference in the level of VC between the two groups after treatment (P<0.05). ④The serum level of IFN-γ increased and the serum levels of TGF-beta 1 and IL-17 decreased in both groups after treatment (P<0.05); after treatment, the serum level of IFN-γ was higher in the treatment group than in the control group (P<0.05). Conclusion:Yanghe Yifei decoction combined with Western medicine shows satisfactory effect in treatment of pulmonary fibrosis of the lung-kidney yang deficiency type. It improves the clinical symptoms better than Western medicine alone and its mechanism of action may be related to up-regulation of the expression level of serum IFN-γ.关键词：pulmonary fibrosis;lung-kidney yang deficiency;integrated Chinese and Western medicine therapy;Yanghe Yifei decoction
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发布时间：2022-08-31 - 摘要：Objective:To observe the clinical efficacy of Xiexin Ningshen decoction in the treatment of children with attention deficit hyperactivity disorder (ADHD) of the heart-liver fire hyperactivity type. MethodsOne hundred and forty-four children with ADHD of the heart-liver fire hyperactivity type were randomly assigned into treatment group and control group, 72 children in each group. The treatment group was treated with Xiexin Ningshen decoction and the control group was given piperformate hydrochloride sustained release tablet. The treatment course was 12 weeks. Changes in TCM syndrome score and hyperactivity index and safety were observed in the groups. Results:①After treatment for 12 weeks, the total effective rate was 84.72% and 80.56% in the treatment group and the control group, respectively. ②After treatment, mean of the TCM syndrome (primary and secondary) scores decreased significantly in both groups (P<0.05). After treatment, there was significant difference in edginess scores (P<0.05), with no statistically significant difference in other scores between the groups (P>0.05). ③After treatment, scores of the Conners parent symptom questionnaire and the hyperactivity index decreased significantly in the groups (P<0.05), with no statistically significant difference between the groups (P>0.05). ④The safety index was normal and there were no major adverse reactions in the groups after treatment. Conclusion:Xiexin Ningshen decoction is effective in the treatment of children with ADHD of the heart-liver fire hyperactivity type, and improves the symptoms of hyperactivity in children, which is worthy of promotion and application.关键词：Xiexin Ningshen decoction;heart-liver fire hyperactivity type;attention deficit hyperactivity disorder
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发布时间：2022-08-31 - 摘要：Objective:To observe the short-term efficacy of ear point-pressing in reducing pain in patients with lumbar disc herniation (LDH). MethodsNinety-six patients with LDH were randomly assigned into treatment group and control group, forty-eight patients in each group. The treatment group was treated with ear point-pressing combined with Jinbi recipe. The control group was given sham ear point-pressing combined with Jinbi recipe. The treatment course was 2 weeks in both groups. Safety was observed, and the pain VAS score, tenderness threshold score, pain tolerance threshold score and Oswestry dysfunction index (ODI) questionnaire score were compared. Results:①During the trial, there were 8 and 6 drop-outs in the treatment group and the control group, respectively. 40 patients in the treatment group and 42 in the control group completed the study. ②From the start of treatment to day 14 of treatment, the VAS scores showed a decreasing trend in both groups, with more significant decrease in the treatment group. There were significant differences in VAS scores at 60 minutes and 7 days after treatment, with lower scores in the treatment group than in the control group (P<0.05). ③From the start of treatment to day 14 of treatment, the tenderness threshold scores generally increased first and then decreased in both groups. The tenderness threshold score showed a more obvious tendency in the treatment group, having the highest value at 60 minutes after treatment, while the highest value occurred at 7 days after treatment in the control group. At 60 minutes after treatment, the tenderness threshold score was higher in the treatment group than in the control group (P<0.05). ④From the start of treatment to day 14 of treatment, the pain tolerance threshold scores generally increased first and then decreased in both groups, with a more obvious tendency in the treatment group. The highest value occurred at 7 days after treatment in both groups. There were significant differences in pain tolerance threshold scores at 60 minutes and 7 days after treatment, with higher scores in the treatment group than in the control group (P<0.05). ⑤There were significant differences in ODI scores at 7 and 14 days after treatment, with significantly lower scores in the treatment group than in the control group (P<0.05). ⑥During the trial, no adverse reactions occurred in either group. Conclusion:Compared with Jinbi recipe alone, the addition of ear point-pressing can better improve the patients’ tenderness threshold and pain tolerance threshold in a short term, and quickly reduce the degree of low back pain. This effect can last up to 7 days after treatment. The addition of ear point-pressing can also relieve lumbar vertebral dysfunction more remarkably in patients within 14 days.关键词：lumbar disc herniation;ear point-pressing;Jinbi recipe;short-term effiacy;pain relief
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发布时间：2022-08-31 - 摘要：Objective:To observe the clinical efficacy of sphincter preservation in the treatment of posterior anal canal abscess. MethodsOne hundred and thirty-four patients with posterior anal canal abscess were randomly assigned into treatment group (70 cases) and control group (64 cases). The control group was treated with stage I radical operation for perianal abscess and the treatment group was treated with sphincter preservation. The clinical efficacy was observed, and the postoperative VAS pain score of wound, wound granulation growth score, postoperative anal function score and the time to exfoliation of septic tissue, disappearance of exudate and wound healing were compared between the groups. Results:①The total effective rate was 95.7% and 92.2% in the treatment group and the control group, respectively. The clinical efficacy was superior in the treatment group to that in the control group (P<0.05). ②At 3,4, 5 and 6 days after operation, the VAS pain score of wound was lower in the treatment group than in the control group (P<0.05). ③In the treatment group, the time to exfoliation of septic tissue, disappearance of exudate and wound healing was shorter in the treatment group than in the control group (P<0.05). ④At 7,4 and 21 days after operation, the wound granulation growth score was lower in the treatment group than in the control group (P<0.05). ⑤At 1 and 6 months after operation, the anal function score was lower in the treatment group than in the control group (P<0.05). Conclusion:Sphincter preservation is effective in the treatment of posterior anal canal abscess, effectively protecting anal function, reducing postoperative pain and shortening the time to wound healing.关键词：posterior anal canal abscess;perianorectal abscess;sphincter preservation
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发布时间：2022-08-31 - 摘要：Objective:To investigate the protective effect of Liuwei Dihuang pill on liver injury in mice with yin deficiency induced by thyroxine. MethodsThirty ICR mice were randomly divided into normal group, model group and Liuwei Dihuang pill group (1.8 g crude drug/kg). Except for the normal group, mice in the other groups were injected subcutaneously with L-thyroxine (280 μg/kg) solution to establish the model of yin deficiency. One week later, the solution of Liuwei Dihuang pill was given by intragastric administration, while L-thyroxine was continued to be administered subcutaneously for 3 weeks. During this period, body mass, temperature, number of locomotor activities, pain threshold and heart rate of the mice were measured to evaluate the yin deficiency model and antagonistic effect of the drug. At the end of experiment, the serum activities of alanine aminotransferase (ALT) and aspartate aminotransferase (AST), and contents of total protein (TP), total cholesterol (TC) and triglyceride (TG) were determined; the liver was dissected and weighed to calculate the liver index; the contents of phosphocreatin (PCr), adenosine triphosphate (ATP), adenosine monophosphate (ADP), adenosine monophosphate (AMP) and cyclic adenosine monophosphate (cAMP) in liver were determined by HPLC and the total adenylate content TAN (ATP+ADP+AMP) was calculated. Results:The yin deficiency indicators such as body mass, temperature, number of locomotor activities, pain threshold and heart rate of the model mice were abnormal, and Liuwei Dihuang pill showed certain effect in improving these Compared with the normal group, the liver index and the serum activities of ALT and AST increased significantly, the serum levels of TC and TP decreased significantly and the contents of ATP, ADP, AMP, cAMP and TAN in liver tissues decreased significantly in the model group(P<0.05,P<0.01). Compared with the model group, the serum activities of ALT and AST decreased significantly in the Liuwei Dihuang pill group, the serum levels of TC and TP increased significantly, and in liver tissues, the contents of ADP, cAMP and TAN increased significantly(P<0.05,P<0.01), and the contents of ATP and AMP also increased in the Liuwei Dihuang pill group. Conclusion:Liuwei Dihuang pill has a certain protective effect on liver injury induced by L-thyroxine in mice with yin deficiency, which may be related to the improvement of energy metabolism disorder in liver tissues.关键词：Liuwei Dihuang Pill;yin deficiency syndrome;liver injury;energy metabolism;mice
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发布时间：2022-08-31 - 摘要：Objective:To investigate the effects of Yushen Zhuyun decoction on the protein and mRNA expression of Bcl-2, Bax and Caspase-3 in ovaries of rats with diminished ovarian reserve. MethodsForty-eight female SD rats were randomly divided into control group, model group, Prognova group, and low-, medium- and high-dose Yushen Zhuyun decoction groups, 8 rats in each group. Except for the control group, the other groups were treated with tripterygium glycosides to establish rat models of diminished ovarian reserve. All of the animals were treated for two weeks. The protein expression levels of Bcl-2, Bax and Caspase-3 in ovarian tissues and cells were detected by immunohistochemistry and Western blot. The mRNA expression levels of Bcl-2, Bax and Caspase-3 in ovarian cells were detected by Real-time PCR. Results:Compared with the control group, the protein and mRNA expression levels of Bcl-2 decreased significantly, and the protein and mRNA levels of Bax、Caspase-3 increased siginifantly in the model group (P<0.05). Compared with the model group, the protein expression level of Bcl-2 increased significantly, and the protein and mRNA expression levels of Bax and Caspase-3 decreased significantly in the Prognova group and the Yushen Zhuyun decoction groups (P<0.05). The mRNA expression levels of Bcl-2 in the Prognova group and the high-dose Yushen Zhuyun decoction group was significantly higher than that in the model group (P<0.05). Compared with the low-dose Yushen Zhuyun decoction group, the mRNA expression level of Bcl-2 increased significantly in the nigh-dose Yushen Zhuyun decoction group, and the protein expression level of Bax decreased obviously in the medium-and high-dose Yushen Zhuyun decoction group (P<0.05). Conclusion:Yushen Zhuyun decoction can up-regulate the protein and mRNA expression of Bcl-2, down-regulate the protein and mRNA expression of Bax and Caspase-3 in ovarian tissues and cells to promote proliferation and inhibit excessive apoptosis of ovarian granulosa cells, thus improving the function of ovarian reserve.关键词：Yushen Zhuyun decoction;diminished ovarian reserve;rats;apoptosis;Bcl-2;Bax;caspase-3
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发布时间：2022-08-31 - 摘要：Objective:To study the protective effect of yam polysaccharides on immune system damage induced by continuous low-density microwave radiation in mice. MethodsICR male mice were randomly divided into 5 groups: blank control group, radiation injury group, and low-, medium- and high-dose yam polysaccharides groups (200,0 and 800 mg/kg). Except for the blank control group, mice in the other groups were exposed to microwave radiation at 10 mW/cm2, 5 min/d for 30 consecutive days to establish the mice model of continuous low-density microwave radiation. Starting from day 21 of radiation, the mice in the low-, medium- and high-dose yam polysaccharides groups were orally administered with yam polysaccharides at 200,0 and 800 mg/kg respectively, and those in the blank control group and the radiation injury group were given distilled water of equal volume. All of the animals were treated for 10 consecutive days. Relevant indicators of cellular immunity and humoral immunity, including thymus index, spleen index, macrophage phagocytosis index, T lymphocyte proliferation rate and the serum levels of IgG and IL-4 were determined. Results:Compared with the blank control group, spleen index, macrophage phagocytosis index, T lymphocyte proliferation rate and the serum level of IgG decreased and the serum level of IL-4 increased in the radiation injury group, with significant differences (P<0.05, P<0.01). Compared with the radiation injury group, macrophage phagocytosis index, T lymphocyte proliferation rate and the serum level of IgG increased and the serum level of IL-4 decreased in the yam polysaccharides groups (P<0.05, P<0.01). Conclusion:Yam polysaccharides significantly improve the impaired immune system function induced by continuous low-density microwave radiation in mice.关键词：yam polysaccharides;microwave radiation;mice;immune function
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发布时间：2022-08-31 - 摘要：Objective:To establish the quality control standards for Shaoshang Zhentong ointment (Puhuang, Liujinu, Huangqin, Danshen and Baizhi). MethodsPuhuang, Huangqin, Danshen and Baizhi in this compound ointment were identified qualitatively by thin layer chromatography (TLC). The content of baicalin, luteolin and baicalein were determined by high-performance liquid chromatography (HPLC). Results:In identification by TLC, there was good isolation and specificity, without interference from the negative samples. Baicalin, luteolin and baicalein had a good linearity in the range of 0.52~13.0 μg (r=0.999 9), 0.13~3.3 μg (r=0.999 9) and 0.05~1.2 μg (r=0.999 9), respectively. The mean average recovery of baicalin, luteolin and baicalein was 100.3% (RSD=2.6%), 103.8% (RSD=2.9%), and 103.6% (RSD=2.8%), respectively. Conclusion:This method is easy to operate, specific, accurate and reliable, and it can be used for quality control of Shaoshang Zhentong ointment.关键词：Shaoshang Zhentong ointment;TLC;HPLC;baicalin;luteolin;baicalein
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发布时间：2022-08-31 - 摘要：The immunosuppressive tumor microenvironment is one of the key factors to promote tumor progression. Myeloid-derived suppressor cells(MDSCs)are the main immunosuppressive cells involved in the formation of tumor immune microenvironment,representing the heterogeneous group of immature bone marrow cells,proliferating,activating and exerting significant immunosuppressive activity under the pathological conditions. MDSCs are also the potential therapeutic targets for tumor immunotherapy. This article summarizes the origin,phenotype and biological characteristics of MDSCs,as well as its mechanisms on tumor immune escape, targeted therapeutic strategies for MDSCs and effects of Chinese medicine monomer on MDSCs, so as to provide references for tumor immunotherapy.关键词：tumor;myeloid-derived suppressor cells;immunosuppression;Chinese medicine monomer;review
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发布时间：2022-08-31 - 摘要：The recent research progress on the regulation of signaling pathways of prostatic carcinoma by traditional Chinese medicine (TCM) is reviewed in this paper.Traditional Chinese medicine can regulate and control many signal pathways of prostatic carcinoma. Classified according to its mechanism of action, itmainly includes the regulation of Notch signal pathways of prostatic carcinoma (such as emodin, curcumin, ginsenoside Rh2, isoorientin, etc.), the regulation of phosphatidylinositol-3-kinase (PI3K)/AKT signaling pathway in prostatic carcinoma (such as matrine, baicalein, icariin, sarcandra glabra, Qianliexiaozheng Decoction, Chinese medicine compound CFF-1, etc.), the regulation of secretory glycoprotein (Wnt)/ β-catenin signaling pathway in prostatic carcinoma (such as Qianlixiaozheng Decoction, Quercetin, etc.), the regulation of transforming growth factor-β (TGF-β)/Smads signaling pathway in prostatic carcinoma (such as forsythia triterpenes, curcumin, etc.), and the regulation of nuclear transcription factor (NF-κB) signaling pathway in prostatic carcinoma (such as tripterine, oridonin, curcumin, etc.). These regulations can block the cell cycle of prostatic carcinoma, inhibit cell proliferation, enhance chemosensitivity, inhibit cell migration, cloning and invasion, induce cell apoptosis, and thus play a corresponding therapeutic role.关键词：prostatic carcinoma;therapy of traditional Chinese medicine;signal pathway;cell activity;review
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发布时间：2022-08-31
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