最新刊期
期 10 ， 2019
- 摘要：Couplet medicines,also known as “couplets”,“pairs”,“brothers” and “sister” medicines, are commonly used in clinic,relatively fixed compatibility of two medicines,is the smallest unit in the compatibility of traditional Chinese medicine,but also the basis of complex prescription composition . Professor Wang Yongjun,proceeding from the classical theory of kidney essence, inherited the characteristics of Shi's theory of traumatology,took filling kidney essence as the fundamental method,used the pairs of Fructus Cnidii and Fructus Ligustri Lucidi to treat osteoporosis. This paper summarizes Professor Wang Yongjun's experience in clinical and scientific research,analyzes the compatibility principle of the couplet medicines, and explores its pharmacological mechanism for osteoporosis.
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发布时间：2022-08-31 - 摘要：This paper introduces the experience of Professor Yu Jiangyi in the treatment of diabetic kidney disease(DKD) from the grease. Professor Yu considers that grease is compatible with adipose tissue and it is one of the manifestations of the spleen governing transportation and transformation. Since the disorder of grease in distribution and digestion is a triggering factor for DN, the method of treatment should adhere to the principle of invigorating spleen and eliminating dampness. He comes up with the Qikui granule, which consists of Zhihuangqi(Radix Astragali Preparata), Zhiheshouwu (Radix Polygoni multiflori Preparata) and Huangshukuihua(Flos Abelmoschi Manihot),being widely used in the clinical treatment of DN.关键词：diabetic kidney disease;grease;adipose tissue;Qikui Granule;clinical experience
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发布时间：2022-08-31 - 摘要：This paper introduces the clinical experience of Professor Nan Zheng in the treatment of diabetic nephropathy( DN). Based on the pathogenesis of “kidney collaterals impaired by toxin and pathogenic factors remaining in Moyuan”, Professor Nan Zheng treats the disease by the basic methods of eliminating pathogenic factors from Moyuan, nourishing kidney and removing toxical material, and expelling pathogenic factors to dredge collaterals as well as the methods of relieving sore-throat to remove toxic materials, treating diseases of the lower part by treating the upper part of the body, enteroclysis and warmly purging water toxin. So the purpose of harmonizing yin and yang, regulating qi and protecting primordial qi of the kidney is achieved.关键词：diabetic nephropathy;kidney collaterals impaired by toxin;pathogenic factors remaining in Moyuan;experience of famous doctor
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发布时间：2022-08-31 - 摘要：The classics of traditional Chinese medicine(TCM) are not only the guiding source of the theoretical system of traditional Chinese medicine, but also the fundamental law guiding the clinical practice of TCM. As a Chinese medicine practitioner, we must carefully learn classics of traditional Chinese medicine. To studying classics of traditional Chinese medicine, we must strive to integrate all the theories into clinical practice on the premise of reading and understanding classics of traditional Chinese medicine. To study the classics of traditional Chinese medicine, we should not only base on practice, but also guide the clinical practice with the classical theory of traditional Chinese medicine. Only the combination of theory and practice can complement each other, and improve the level of Chinese medicine theory and clinical practice.关键词：classics of traditional Chinese medicine;theory of traditional Chinese medicine;clinical practice;Chinese medicine master
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发布时间：2022-08-31 - 关键词：SHEN Ziyin;academic achievements;essence of kidney’s viscera state;experiment research;rules of treatment in TCM
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发布时间：2022-08-31 - 摘要：This paper analyzes the pathogenesis of gastroesophageal reflux related asthma from the perspective of literature about both Chinese and Western medicine, and discusses the strategy for treating this disease with Chinese medicine. As regards pathogenesis, there are mainly reflux stimulation theory, nerve reflex theory and neuropeptide stimulation theory. It is believed that “asthma” is only the consequence, and that the retrograde movement of gastric and duodenal contents along the esophagus is the fundamental reason. In the treatment of this condition, Chinese medicine should focus on fortifying the spleen and harmonizing the stomach, in order to treat the stomach to calm the lung and relieve asthma without treating asthma. At the same time, attention should be paid to avoiding mistaken identification of the location and nature of the disease.关键词：gastroesophageal reflux disease;gastroesophageal reflux related asthma;refractory asthma;pathogenesis;Chinese medicine;fortify the spleen and harmonize the stomach
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发布时间：2022-08-31 - 摘要：The strategies, misconceptions, technical methods and preferred protocols of cell autophagy research, as well as the regulatory mechanism of autophagy in non-alcoholic fatty liver disease (NAFLD) are discussed. At the same time, the current status of research on autophagy mechanism in TCM treatment of NAFLD is discussed. Autophagy is believed to protect hepatocytes in pathogenesis (mainly the early stage) and treatment of NAFLD, and to some extent delay the development of the disease. The protective effect of autophagy may also be reflected in the micro-effect mechanism of traditional Chinese medicine in the treatment of potential diseases by “preventing development and transmission of diseases”. Autophagy is currently in the ascendant in the research of mechanism of Chinese medicine intervention in diseases and has broad research prospects. However, there are still research bottlenecks. Based on the staged achievements in the standardization of traditional Chinese medicine, it is possible to speed up the autophagy research in traditional Chinese medicine by developing new in-vitro techniques, combined with high-throughput bioinformation collection and cutting-edge bioanalytical techniques.关键词：autophagy;hepatocyte;non-alcoholic fatty liver disease;mitophagy;lipophagy;regulatory mechanism;target of traditional Chinese medicine effect
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发布时间：2022-08-31 - 摘要：Objective:To explore the distribution pattern of TCM syndromes of diabetic foot gangrene (tendon gangrene), and to provide reference for TCM syndrome differentiation and its objectification and standardization of diabetic foot gangrene (tendon gangrene). Methods136 patients with diabetic foot gangrene (tendon gangrene) were included, a four-diagnostic-method information collection table for diabetic foot gangrene (tendon gangrene) and a database were established. Statistical methods such as factor analysis and cluster analysis, and syndrome element differentiation methodology were used to conduct TCM syndrome research. Results:A total of 17 common factors were obtained by factor analysis, a cluster analysis was performed considering professional knowledge, and 4 valid TCM syndromes were obtained according to the method of syndrome element differentiation. The syndromes are the following in the descending order: syndrome of excessive dampness-heat and toxin, syndrome of blood vessel stasis and obstruction, syndrome of qi and blood deficiency and syndrome of toxic heat injuring yin. Conclusion:The most commonly-seen syndrome of diabetic foot gangrene (tendon gangrene) is syndrome of excessive dampness-heat and toxin, with dampness-heat being the main syndrome element; followed by syndrome of blood vessel stasis and obstruction, syndrome of qi and blood deficiency and syndrome of toxic heat injuring yin.关键词：diabetic foot gangrene;tendon gangrene;TCM syndrome;syndrome element differentiation;syndrome of excessive dampness-heat and toxin
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发布时间：2022-08-31 - 摘要：Objective:To detect the expression levels of angiogenic tumor markers, hypoxia inducible factor-1α(HIF-1α) and vascular endothelial growth factor (VEGF) in tumor tissue of colorectal cancer patients with blood stasis syndrome or non-blood stasis syndrome, and analysis the relationship between blood stasis syndrome and tumor angiogenesis. MethodsOne hundred and sixteen patients (retrospective cases) were divided into the blood stasis syndrome group and non-blood stasis syndrome group. The positive expressions of angiogenic tumor markers, HIF-1α and VEGF in tumor tissue were measured by immunohistochemistry, and combined with clinical stages, the differences on the expressions of above indicators in colorectal cancer patients with blood stasis syndrome or non-blood stasis syndrome were analyzed. Results:① The clinical stages of colorectal cancer patients with blood stasis syndrome or non-blood stasis syndrome were mainly stage Ⅱa and stage Ⅲb, and there was no statistical significance between the two groups (P>0.05). ② There was statistically significant difference on the positive expression of vascular CD34 in tumor tissue between colorectal cancer patients with blood stasis syndrome and those patients with non-blood stasis syndrome(P＜0.001), but there were no statistically significant differences on the positive expressions of CK-7, CK-20, CEA, CDX-2, p53, Ki-67, nerve S-100 and lymphatic D2-40 (P>0.05). ③ The positive expressions of HIF-1α and VEGF in tumor tissue of colorectal cancer patients with blood stasis syndrome were significantly higher than those of colorectal cancer patients with non-blood stasis syndrome (P<0.001). Conclusion:Compared with colorectal cancer patients with non-blood stasis syndrome, the positive expressions of CD34, HIF-1α and VEGF in tumor are significantly increased in patients with blood stasis syndrome, which suggests that blood stasis syndrome of colorectal cancer is closely related to tumor angiogenesis.
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发布时间：2022-08-31 - 摘要：To discuss the progress and relevant issues in biomarker research on blood flow signals at acupoints. Acupoints can not only be used to treat diseases, but also reflect the functional state of viscera under certain conditions. In diseases, the functional state of some acupoints changes, accompanied by changes in microcirculation. Our study shows that coherence analysis between blood flow signals can be used not only to distinguish different age groups, but also to distinguish different cold stimulation of the digestive tract. Therefore, blood flow signals at acupoints can be used as a potential biomarker for evaluating the functional state of the body.关键词：acupoint;biomarker;laser doppler blood flow signal;coherence analysis
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发布时间：2022-08-31 - 摘要：Yu Genchu, the founder of Shao school of cold damage diseases, advocated the treatment methods of Zhang Zhongjing and the treatment methods for warm diseases. His book Popular Treatise on Cold Damage diseases, contains 17 sorts of purgative prescriptions, 10 in the name of Chengqi, 7 in other name but secretly meanig Chengqi, with perfect theory and method as well as detailed prescriptions and herbs. This paper categorizes the 17 prescription, introducing the origin and development of each prescription and the body pathophysiology of the reaction behind it, in order to fully present Yu’s rich experience and ways of syndrome differentiation in treating yangming fu-organ excess syndrome.关键词：Popular Treatise on Cold Damage diseases;Yu Genchu;Yangming disease;purgative method
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发布时间：2022-08-31 - 摘要：The warming method in the six channels and nine differentiation methods is divided into the methods of warming and dispersing, warming and reinforcing and restoring yang. The warming method is expounded respectively from aspects of the main points of diagnosis and treatment, treatment method and prescription and its evolution in later generations. The corresponding basic prescriptions, analogical prescriptions and modified prescriptions are summarized.关键词：six channels and nine differentiation methods;warming and dispersing method in Taiyang channel;warming and reinforcing method in Taiyin channel;restoring yang method in Shaoyin channel;main points of diagnosis and treatment;modified prescriptions
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发布时间：2022-08-31 - 摘要：By combing the original text of Treatise on Febrile and Miscellaneous Disease, referring to the theories of different schools, and combining with the theory of essence qi in Chinese classical philosophy and traditional Chinese medicine, it is considered that Shenqi Wan (pill for invigorating kidney qi) promotes the vaporization function of the kidney mainly by stimulating kidney essence transforming into kidney qi, that is, minor fire generating kidney qi. The medicine is mainly used to treat the disease with retention of fluid and dampness caused by failure of essence transforming into qi and dysfunction of qi transformation.关键词：Shenqi Wan;kidney yang deficiency;mutual transformation between essence and qi;minor fire generating kidney qi;retention of fluid and dampness
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发布时间：2022-08-31 - 摘要：By using the retrieval tool of ancient books in Chinese Medical Code and with the help of knowledge archaeology, the related discussion of “liver without reinforcing method” in ancient books of traditional Chinese medicine was sorted out, and its theoretical formation and historical evolution were explored. It was found that the views of doctors were roughly divided into three categories:believing that “liver without reinforcing method” is a previous fallacy; approving of “liver without reinforcing method”, but considering that the circulation of qi and blood is the method of reinforcement; agreeing on “liver without reinforcing method” and liver not bing reinforced. It is considered that the “liver without reinforcing method” should be viewed dialectically, and the liver should not be treated with this concept by suppressing the liver and purging the liver; the liver qi should be replenished carefully while the liver blood can be nourished, and the excess syndrome of the liver should not be supplemented while the liver deficiency should be replenished.关键词：liver excess;liver deficiency;therapy of traditional Chinese medicine;theoretical research;knowledge archaeology
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发布时间：2022-08-31 - 摘要：Objective:To observe the clinical efficacy in treatment of cervical spondylotic radiculopathy in young people with needle knife loosening therapy at positive reaction points at fixed-point rotating position. MethodsSixty young patients with cervical spondylotic radiculopathy were randomly assigned into treatment group and control group, 30 patients in each group. The treatment group was treated with needle knife loosening therapy at positive reaction points at fixed-point rotating position, while the control group was treated with needle knife loosening therapy at conventional position. The two groups were treated for 10 days. The clinical efficacy was observed and the changes in scores of symptoms and signs and pain VAS score were compared. Results:①The total effective rate was 90.00% and 86.67% in the treatment group and the control group, respectively. There was no significant difference in clinical efficacy between the two groups (P>0.05). ②After 5 and 10 days of treatment, the scores of symptoms and signs were higher in the treatment group than in the control group, and the pain VAS score was lower in the treatment group than in the control group (P<0.05). Conclusion:The overall efficacy of needle knife loosening therapy at fixed-point rotating position in young patients with cervical spondylotic radiculopathy is comparable with that of therapy at conventional position, but this new method has easy-to-find needle insertion point, shallow needle insertion and high safety, and it causes less damage to normal soft tissues, more easily accepted by patients.关键词：cervical spondylotic radiculopathy;young people;needle knife therapy;fixed-point rotating position;positive reaction points
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发布时间：2022-08-31 - 摘要：Objective:To analyze the clinical efficacy of “Xiao Xingnao Kaiqiao” acupuncture combined with “Wei’s” chiropractic manipulation in the treatment of cervical vertigo. MethodsSixty patients with cervical vertigo in the Department of Spine, Xi’an Hospital of Traditional Chinese Medicine were randomly assigned into treatment group and control group, 30 patients in each group. The treatment group was treated with “Xiao Xingnao Kaiqiao” acupuncture and “Wei’s” chiropractic manipulation. The control group was treated with traditional acupuncture and “Wei’s” chiropractic manipulation. The course of treatment was 10 days in both groups. The clinical efficacy was observed. The changes of symptom and function scores in cervical vertigo and mean vertebrobasilar artery blood flow velocity were compared. Results:①The total effective rate was 96.7% and 80.0% in the treatment group and the control group respectively. Clinical efficacy in the treatment group was superior to that in the control group (P<0.05). ②After treatment, the symptom and function scores in cervical vertigo were increased in both groups compared with those before treatment (P<0.05). The symptom and function scores in cervical vertigo were higher in the treatment group than in the control group after treatment (P<0.05). ③After treatment, the mean vertebrobasilar artery blood flow velocity was increased in both groups compared with that before treatment (P<0.05). The mean vertebrobasilar artery blood flow velocity was higher in the treatment group than in the control group after treatment (P<0.05). Conclusion:“Xiao Xingnao Kaiqiao” acupuncture combined with “Wei’s” chiropractic manipulation shows good clinical efficacy in the treatment of cervical vertigo, and can significantly improve the patient’s vertigo symptoms.关键词：cervical vertigo;Xiao Xingnao Kaiqiao;acupuncture;Wei’s chiropractic manipulation
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发布时间：2022-08-31 - 摘要：Objective:To observe the differences in therapeutic effect of silver needle, filiform needle and anti-inflammatory and analgesic drugs combined with massage in the treatment of lumbar disc herniation (LDH) and to preliminarily explore the optimal combination of acupuncture and massage for treating LDH in Lu`s Traumatology Department. Methods120 patients with LDH were randomly assigned into three groups, 40 patients in each group. The three groups were treated with needle warming moxibustion using silver needle and stainless-steel needle and non-steroidal anti-inflammatory analgesics, respectively. Half of the patients in each group were randomly treated with or without massage, 20 patients in each subgroup. All the indicators were observed at 5 time phases, namely T0 (baseline point before treatment), T1 (day 17±2), T2 (day 35±2), T3 (day 60±2) and T4 (day 90±2), with T2 as the endpoint for determination of treatment effect. At T2, the observation indicators of each group were collected and statistics were obtained. Results:The effective rate was 87.5%, 75.0% and 57.5% in the silver needle group, the filiform needle group and the drug group, respectively after treatment, with significant differences in clinical efficacy (P＜0.05). The ODI scores of the three groups changed after treatment (P＜0.05), and symptoms improved with the 3 treatment methods. After treatment, there were significant differences in the pain scale scores in the silver needle group, the filiform needle group and the drug group (P＜0.05), with more improvements in the silver needle group. Effect was observed with massage alone, and there was no interaction with other therapies in post-hoc analysis. Conclusion:Needle warming moxibustion in Lu`s Traumatology Department can alleviate the pain and functional symptoms of lumbar intervertebral disc. Needle warming moxibustion using silver needle shows remarkable effect and the effect is even better when combined with massage.关键词：lumbar disc herniation;acupuncture and moxibustion;silver needle;massage;optimized regimen
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发布时间：2022-08-31 - 摘要：Objective:To systematically evaluate the efficacy and safety of Shaobei Injection in the treatment of mixed hemorrhoids and internal hemorrhoids. MethodsThe related databases at home and abroad were searched by computer, and literature on clinical randomized controlled trials of Shaobai Injection in the treatment of mixed hemorrhoids and internal hemorrhoids using Xiaozhiling Injection as control were collected. The search time limit was from establishment of the database to December 2018.Meta-analysis was performed using RevMan5.2. Results:A total of 15 randomized controlled trials involving 4,8 patients were included. The meta-analysis results showed that compared with Xiaozhiling Injection, Shaobai Injection had better comprehensive effect on mixed hemorrhoids and internal hemorrhoids [RR=1.19,5% CI(1.12,1.25), Z=6.17, P<0.01], and could significantly reduce the overall incidence of postoperative adverse reactions [RR=0.04,5% CI(0.02,0.07), Z=9.56, P<0.01], the incidence of postoperative rectal induration [RR=0.01,5% CI(0.01,0.03), Z=10.14, P<0.01], the incidence of postoperative bleeding [RR=0.09,5% CI(0.02,0.30), Z=3.80, P<0.01], and the incidence of postoperative anorectal stenosis [RR=0.07,5% CI(0.02,0.21), Z=4.56, P<0.01]. Conclusion:Compared with Xiaozhiling Injection, Shaobai Injection has better overall efficacy in the treatment of mixed hemorrhoids and internal hemorrhoids, and can reduce the incidence of adverse reactions after operation. However, due to the low quality of literature, the above conclusion needs to be verified by follow-up study results.关键词：Shaobei Injection;Xiaozhiling Injection;hemorrhoids;Meta-analysis
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发布时间：2022-08-31 - 摘要：Objective:To explore the analgesic and anti-inflammatory effect and the immunoregulatory mechanism of polysaccharides in Radix et Caulis Acanthopanacis Senticosi. Methods①Sixty SPF Kunming mice were randomly divided into normal group, control group, positive control group and high-, medium- and low-dose groups of polysaccharides in Radix et Caulis Acanthopanacis Senticosi. Except for the normal group (10 mice), the other 50 mice were used to establish the analgesic model by the hot plate method or the acetic acid writhing method. Corresponding intervention was given to each group. Analgesicrate, writhing response inhibition rate, spleen index, thymus index and serum levels of cytokines IL-6, TNF-alpha and IL-1bet were measured in each group. ②Sixty SPF Kunming mice were randomly divided into normal group, control group, positive control group and high-, medium- and low-dose groups of polysaccharides in Radix et Caulis Acanthopanacis Senticosi. Except for the normal group (10 mice), the other 50 mice were taken to establish the model of inflammation by using egg white to induce toe swelling or using acetic acid to induce increase in peritoneal capillary permeability. Corresponding intervention was given to each group. Inhibition rate of toe swelling, inhibition rate of increase in peritoneal capillary permeability, spleen index, thymus index and serum levels of cytokines IL-6, TNF-α and IL-1β were observed in each group. Results:①Compared with the control group, there were increase in pain threshold (P<0.05) and writhing inhibition rate (P<0.05), and decrease to varying degrees in the levels of serum cytokines IL-6, TNF-α and IL-1β (P<0.05) in the positive control group and the high-dose group, and spleen index and thymus index increased to varying degrees in the high-, medium- and low-dose groups (P<0.05). The spleen index, thymus index and the levels of serum cytokine IL-6, TNF-α and IL-1β to varying degrees in the high-, medium- and low-dose groups were higher than the positive control group (P＜0.05). ②Compared with the control group, there were increase in the inhibition rate of toe swelling and inhibition rate of increase in peritoneal capillary permeability (P<0.05), and decrease in the levels of serum cytokines IL-6, TNF-α and IL-1β (P<0.05) in the positive control group and the high-dose group, and spleen index and thymus index increased to varying degrees in the high-, medium- and low-dose groups (P<0.05). The spleen index, thymus index and the levels of serum cytokine IL-6, TNF-α and IL-1β to varying degrees in the high-, medium- and low-dose groups were higher than the positive control group (P＜0.05). Conclusion:Polysaccharides in Radix et Caulis Acanthopanacis Senticosi improve the condition of mice in the analgesic and anti-inflammatory model. The mechanism of action may be improving the index of immune organs and regulating the levels of related immune cytokines.关键词：Radix et Caulis Acanthopanacis Senticosi;polysaccharides;analgesic;anti-inflammatory;immunomodulatory;mice
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发布时间：2022-08-31 - 摘要：Objective:To study the effects of water extracts from different processed products of Rhizoma Polygonati (RP) on rat model of qi and yin deficiency, and to provide reference for scientific processing and clinical rational use of the drug. Methods69 SD rats were randomly divided into normal group and model group. The rat model of qi and yin deficiency was established considering three factors (gavage administration of medicine hot in property, food restriction and weight-bearing swimming) for 2 weeks. 42 rats with successful modeling were randomly divided into model group, positive group, commercial RP group, four-fold processed RP group and nine-fold processed RP group. Each group was given 10 g/kg of water extracts from different processed products or positive drug (Shengmai Drink) for 6 weeks. The general behavioral indicators were observed during administration, including body mass, diameter of tail root, face temperature, grip strength, pain threshold and thermal imaging. After last administration, blood samples were collected from tail root to determine hemoglobin; and blood samples were collected from orbital vein to determine alanine aminotransferase (ALT),aspartate aminotransferase (AST), glucose (GLU), triglyceride (TG) and creatinine (Cr) in blood, and to determine immunoglobulin A (IgA), immunoglobulin M (IgM), adenosine cyclic phosphate (cAMP) and guanosine cyclic phosphate (cGMP) in serum by ELISA. Results:After 2 weeks of modeling, compared with the normal group, there was significant decrease in body mass, GLU, and Cr in the model group, indicating successful modelling. After 6 weeks of administration, compared with the normal group, the indicators (except ALT) were significantly different in the model group (P<0.05, P<0.01); there were significant decrease in tail diameter and GLU and increase in face temperature in the commercial RP group (P<0.05, P<0.01); there were significant decrease in tail diameter and increase in TG in the nine-fold RP group (P<0.01). Compared with the model group, all processed products of RP could improve the general signs (grip strength, diameter of tail root, face temperature, thermal imaging and pain threshold), liver function (decrease in AST and ALT) and glycolipid metabolism (decrease in TG and increase in GLU), increase serum IgA and IgM, and regulate the cyclic nucleotide system of rats with qi and yin deficiency. Commercial RP had desirable effect in improving thermal imaging, immune function and the cyclic nucleotide system (P<0.05, P<0.01). Four-fold processed RP had statistical significance in improving general signs, liver function, glycolipid metabolism, immune function and the cyclic nucleotide system (P<0.05, P<0.01). Nine-fold processed RP significantly improved liver function (P<0.01). Conclusion:Different processed products of RP can improve the symptoms of qi and yin deficiency in rats. Four-fold processed RP has better effect in increasing body mass and tail diameter of the rats with qi and yin deficiency, and it is better at regulating glycolipid metabolism in rats.关键词：Rhizoma Polygonati;processing;qi and yin deficiency;rats
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发布时间：2022-08-31 - 摘要：Objective:To establish the technology and quality control for processing Fructus Aurantii Immaturus simulating ancient method based on ancient and modern medical literatures, and facilitate research and development of Wendan Decoction. MethodsThe content of naringin and neohesperidin was determined by high performance liquid chromatography (HPLC) and other modern analytical techniques. The effects of different processing parameters on the quality of Fructus Aurantii Immaturus were analyzed and discussed. Results:A method was established for the determination of naringin and neohesperidin in Fructus Aurantii Immaturus by HPLC and a method for preparing the test solution was also established. The results of system adaptability test and methodological investigation were good. The processing parameters of Fructus Aurantii Immaturus were determined as follows: the amount of water being 1.4 times of drug material, 55 minutes of mixing and 7 minutes of stir-frying at 120℃. The content of naringin and neohesperidin in Fructus Aurantii Immaturus increased after water processing. Conclusion:Naringin and neohesperidin can be used for quantitative analysis and quality control of medicinal material in Fructus Aurantii Immaturus. The method of processing Fructus Aurantii Immaturus in Wendan Decoction simulating ancient method was determined to be processing with water. The present study provides references for research and development of new drugs in the classic recipe Wendan Decoction.关键词：Wendan Decoction;Fructus Aurantii Immaturus;naringin;neohesperidin;quality control;processing technology
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发布时间：2022-08-31 - 摘要：Objective:To study the content determination of total mercury in Zizhu Ointment and facilitate the establishment of effective quality control methods. MethodsAfter microwave digestion of samples, the content of total mercury in Zizhu Ointment was determined by atomic absorption spectrophotometry (AAS). Results:The linear relationship of the established method was y=0.001 8x+0.000 3, the correlation coefficient was 0.999 9, and the recovery rate was 92.02%-105.84%. The average content of total mercury in Zizhu Ointment was 3.13% with RSD of 2.70%. Conclusion:This method provides a practical and reliable basis for formulation of the quality standards of Zizhu Ointment.关键词：AAS;Zizhu Ointment;total mercury
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发布时间：2022-08-31 - 摘要：The molecular mechanisms involved in cardiac hypertrophy and the latest research progress in preventing and treating the disease with traditional chinese medicine (TCM) are reviewed. Cardiac hypertrophy is a major risk factor for heart failure, which may result from the dysregulation of multiple cellular factors and/or signaling pathways, such as the calcium signaling, AMPK, TLR4/NF-κB, MAPK, PI3K/Akt and oxidative stress-related signaling pathways. Pathological hypertrophy can be prevented or reversed by astragaloside A, gastrodin, ginsenoside, propolis and asiatic pennywort herb by regulating related pathways, thereby avoiding progression to heart failure.关键词：cardiac hypertrophy;Chinese medicine;signaling pathway;review
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发布时间：2022-08-31
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