最新刊期
期 1 ， 2019
- 摘要：The author introduces the academic viewpoints of Prof. Jiang Jian by analyzing clinical proven cases of treating enuresis,chest pain,spasm and abdominal pain with Shaoyao Gancao Decoction. Prof. Jiang holds that Shaoyao Gancao Decoction is well formulated,cost-effective,and can be used on a variety of diseases and syndromes. When the dosage is not effective or the effect of conventional dosage is not ideal,the therapeutic effect can be achieved by increasing the quantity of some key drugs in the prescription on the premise of accurate diagnosis of syndrome differentiation and disease differentiation.关键词：Shaoyao Gancao Decoction;dose-effect relationship;medication safety;clinical proven case;Jiang Jian
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发布时间：2022-08-31 - 摘要：This paper introduces Prof. Que Huafa’s clinical experience in the differentiation and treatment of plasma cell mastitis. It is suggested that the disease should be diagnosed first, combined with syndrome differentiation. And the internal and external treatment should be decided by differentiating the cause of the disease, patient’s constitution, and local condition. One proven case is presented.关键词：plasma cell mastitis;therapy of traditional Chinese medicine;clinical’s experience;Que Huafa
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发布时间：2022-08-31 - 摘要：The paper explores Prof. Yu Zhiqiang’s experience in treating coronary heart disease from the liver. It is believed that the treatment of coronary heart disease should be based on the treatment of the liver and the treatment methods are put forward such as soothing liver to regulate qi,activating blood circulation to resolve stasis; clearing the liver to reduce fire,resolving phlegm to eliminate arthralgia,calming the liver to suppress wind,nourishing yin to activate blood circulation; nourishing blood to soften the liver,calming the heart to restore pulse,warming the meridian to disperse cold and warming the liver to dredge collaterals. One proven case is presented.关键词：coronary heart disease;treatment from the liver;experience of famous doctors;Yu Zhiqiang
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发布时间：2022-08-31 - 摘要：This paper explores Prof. Li Feiyue’s experience in treating knee pain with internal obstruction of turbid dampness. Prof. Li thinks that with the changes of pathogenesis,the syndrome of superabundance of dampness due to spleen-asthenia,or the syndrome of wind,cold,heat,phlegm and summer-heat can appear in the disease. Therefore the disease is treated with traditional Chinese medicine based on syndrome differentiation,mainly by expelling dampness and resolving turbidity,or by expelling wind and dissipating cold,clearing away heat and expelling summer-heat. It is also treated by external application of traditional Chinese medicine,lotion and manipulation. Two proven cases are presented.关键词：Knee pain;internal obstruction of turbid dampness;clinical experience;Wei’s Department of Traumatology;Li Feiyue.
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发布时间：2022-08-31 - 摘要：This paper introduces Prof. Zhang Qin’s experience in treating dysmenorrhea due to adenomyosis. It is believed that the pathogenesis of the disease is based on deficiency of the spleen and kidney with the mixture of water and blood stasis as a secondary aspect. The way used to treat it is to warm up the spleen and kidney and remove water and blood stasis. According to the regularity of menstrual cycle,the disease should be treated by stages,together with retention enema of traditional Chinese medicine preparation and the influence of emotional factors on the disease should be paid attention to. One proven case is presented.关键词：adenomyosis;dysmenorrhea;removing water and blood stasis;clinical experience;Zhang Qin
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发布时间：2022-08-31 - 摘要：This paper introduces the clinical experience of Prof. Deng Tietao,a master of Chinese medicine,in the treatment of internal diseases in Lingnan (south of the Five Ridges). Prof. Deng specializes in using paste prescription and attaches importance to the clinical application of the theory of ‘spleen regulating blood’ in order to treat the root of blood syndrome in Lingnan. It is pointed out that ‘damp-heat of three Jiao in qi aspect’ is the common pathogenesis of febrile disease in Lingnan. He is adept in differentiating exogenous and internal diseases,and treating the diseases with characteristic Lingnan herbs such as Huangqi (Radix Astragali),Muhudie(Semen Oroxyli),Xiqiɑncɑo(Herba Siegesbeckiae) and so on. Professor Deng pays attention to the theory of the relation of heart and spleen. He holds that the pathogenesis of palpitation in Lingnan is the deficiency of qi and yin,turbid phlegm blocking collaterals and Deng’s Wendan Decoction is used for the treatment. One proven case is presented.关键词：Lingnan (south of the Five Ridges);internal diseases;blood syndrome;fever;palpitation;famous doctor’s experience;Deng Tietao
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发布时间：2022-08-31 - 摘要：The author emphasizes the integrity of TCM clinical classics in diagnosis and treatment of diseases. The etiologies of the diseases are explained by hemorrhagic fever. The rules of syndrome and treatment are summarized by the method of six jing and nine points, and the pattern of diagnosis and treatment is highlighted by the method of four points for pyreticosis. From the perspective of clinical diagnosis and treatment system, the historical context and the original position of Treatise on Cold Pathogenic diseases, Essential Prescriptions of the Golden Cabinet and Epidemic Febrile Diseases are clarified.关键词：typhoid fever;miscellaneous diseases;epidemic febrile diseases;integrative theory
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发布时间：2022-08-31 - 摘要：Through analyzing the consensuses on the diagnosis and treatment of gastroesophageal reflux disease (GERD) with both Chinese and Western medicine and related literature,and taking personal experience into consideration,the author discusses the management of GERD with Chinese medicine in the following four aspects,i.e. syndrome differentiation or disease differentiation,grasping the chief symptom or the main disease,treating the tip or the root; and treating with medication or non-medical approaches. It is suggested that the diagnosis and treatment of the disease should be guided by the theory of traditional Chinese medicine and the principle of seeking the root of the disease,adhering to the combination of traditional Chinese medicine and Western medicine,syndrome differentiation and disease differentiation,and first grasping the main disease and then the main symptoms. Meanwhile, the therapeutic effect of acupuncture and moxibustion should be also attached importance to.关键词：gastroesophageal reflux disease;treatment with traditional Chinese medicine;disease differentiation;syndrome differentiation;acupuncture and moxibustion
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发布时间：2022-08-31 - 摘要：Treatment before symptoms arising,is a method of treating disease based on the law of disease development with the thought of differentiating diseases. It has important theoretical and clinical value and can not be ignored in modern Chinese medicine. Starting from the historical source of treatment before symptoms arising,this paper sums up its course of emergence,evolution and development. Combining with the examples of modern application,the author holds that the strategy of treatment before symptoms arising contains the thought of holistic view of disease and treatment based on differentiation of disease,which has important guiding significance for the clinical practice of traditional Chinese medicine.关键词：treatment before symptoms arising;treatment based on differentiation of disease;treatment based on syndrome differentiation
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发布时间：2022-08-31 - 摘要：Objective:To systematically evaluate the efficacy and safety of acupuncture combined with medicine for cognitive functions and life quality of the patients with Alzheimer’s Disease(AD). MethodsThe randomized controlled trials (RCTs) regarding acupuncture combined with medicine for AD published from January 1st of 2008 to August 31th of 2018 were researched in China National Knowledge Infrastructure,VIP medicine information system,WanFang database,Chinese Biomedical Database,PubMed,Medline,Springer Link and Cochrane Library. The quality assessment was performed based on the guidance of the Cochrane Reviewers’ Handbook,and Meta-analyses was performed by using RevMan 5.3 software. Results:Totally 8 RCTs were included,involving 472 AD patients. The results of Meta-analyses showed that the treatment group was superior to the control group in improving the mini-mental state examination (MMSE)(MD=0.76,95%CI ,P<0.000 01),Alzheimer’s disease assessment scale-cognitive section (ADAS-cog) (MD=-0.32,95%CI ,P=0.03),activities of daily living(ADL)(MD=-0.66,95%CI ,P=0.001). Conclusion:Acupuncture combined with medicine for cognitive functions and life quality of AD patients is effective. However,the included studies were with risk of bias and with clinical heterogeneity. So more RCTs of high quality are needed to further confirm its efficacy and safety.关键词：Alzheimer’s disease;acupuncture;cognitive function;life quality;randomized controlled trial;systematic review
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发布时间：2022-08-31 - 摘要：This paper discusses the experience of treating nephropathy based on Zhang Zhongjing’s theory of ‘fluid-retention syndrome’. According to the characteristics of his prescriptions,the prescriptions for fluid-retention syndrome are reclassified,mainly including Herba ephedrae prescriptions for treating wind edema,Radix Stephaniae and Radix Astragali prescriptions for skin edema,Ramulus Cinnamomi and Poria prescriptions for general edema,and Radix Aconiti Lateralis Preparata prescriptions for general edema and stony edema. At the same time,six corresponding proved cases are reviewed.关键词：fluid-retention syndrome;chronic kidney disease;classical prescriptions;clinical cases
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发布时间：2022-08-31 - 摘要：Based on the analysis of the dialectical thinking mode in Treatise on Cold Pathogenic Diseases and Essential Prescriptions of the Golden Cabinet,this paper holds that the basic dialectical principle of diagnosing and treating diseases in Treatise on Cold Pathogenic Diseases and Essential Prescriptions of the Golden Cabinet,is to distinguish the disease pattern first,then to determine the right prescription based on the specific symptoms.关键词：Treatise on Cold Pathogenic Diseases;Essential Prescriptions of the Golden Cabinet;thinking mode
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发布时间：2022-08-31 - 摘要：By studying the theory of properties and tastes and relevant literatures of Ye Tianshi and Wu Jutong,two TCM doctors specializing in treating epidemic febrile diseases,the author explores and summarizes the specific application rules of epidemic febrile diseases in the syndrome differentiation of ‘Wei(defensive phase),qi(qi phase),ying(nutrient phase),xue(blood phase)’ and ‘Sanjiao’. This paper concludes that the development of the theory of properties and tastes is closely related to its special syndrome differentiation system. In comparison with the syndrome differentiation of ‘wei,qi,ying,xue’ and ‘Sanjiao’ which are characterized by mixed syndromes with distinct levels and a wide coverage,the theory of properties and tastes is more flexible and practical than that of dominator and subordinate in application of Chinese medicine. At the same time,it is pointed out that the application of the theory of properties and tastes to the treatment of miscellaneous diseases and internal injuries under the guidance of the syndrome differentiation system of epidemic febrile diseases,has special clinical advantages and significance in modern TCM.关键词：theory of properties and tastes;system of syndrome differentiation in epidemic febrile diseases;theoretical application
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发布时间：2022-08-31 - 摘要：Objective:To observe the clinical effect of internal and external treatment of traditional Chinese medicine combined with conventional Western medicine for chronic heart failure (CHF) in aged patients with qi-yin deficiency,blood stasis and damp obstruction. MethodsOne hundred and thirty-six aged CHF patients with qi-yin deficiency,blood stasis and damp obstruction were randomly divided into treatment group and control group with 68 cases in each group. The control group was treated with conventional Western medicine,and the treatment group was treated with Qiangxin Ⅱ Decoction,foot bath with herbs and point application with Erwu Wenyang Plaster on the basis of the treatment measures in the control group. The two groups were treated for 2 months. The clinical efficacy and adverse drug reactions were observed,and these indices were compared such as the cardiac function,walking distance of 6 min,levels of serum B natriuretic peptide (BNP),C-reactive protein (CRP) and cardiac troponin I (cTnI). Results:① There were 124 patients,62 patients in each group,who finally completed the trial. ②The total effective rate in the treatment group was significantly higher than that of the control group (91.93% vs 75.80%,P<0.05). ③After treatment,the left ventricular ejection fraction (LVEF) of the treatment group was significantly higher than that of the control group,while the left ventricular end-diastolic diameter (LVEDD) and left ventricular end-systolic diameter (LVESD) of the treatment group were significantly lower than those of the control group (P<0.05). ④After treatment,the walking distance of 6 min in the treatment group was significantly longer than that in the control group (P<0.05). ⑤The levels of serum BNP,CRP and cTnI in the treatment group were lower than those of the control group (P<0.05). ⑥ There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05). Conclusion:The internal and external treatment with traditional Chinese medicine combined with conventional Western medicine can significantly improve clinical efficacy and exercise tolerance,ameliorate cardiac function,reduce levels of serum BNP,CRP and cTnI,and has better safety for CHF in aged patients with qi-yin deficiency,blood stasis and damp obstruction.关键词：Qiangxin II Decoction;point application;herbal foot-bath;Enalapril;chronic heart failure;clinical efficacy
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发布时间：2022-08-31 - 摘要：Objective:To evaluate efficacy and safety of DZWJY - type 1 electronic moxibustion apparatus in treating patients of knee osteoarthritis with traditional moxibustion therapy as control. MethodsOne hundred and twenty-four patients with knee osteoarthritis were randomly divided intoelectronic moxibustion group and traditional moxibustion group with 62 cases in each group. The electronic moxibustion group was treated with DZWJY-1 electronic moxibustion apparatus,and the traditional moxibustion group with traditional moxibustion therapy. The course of treatment in both groups was 4 weeks. The clinical efficacy and safety were observed and the changes of VAS score,WOMAC score (total score and sub-score) of knee pain were compared between the two groups. Results:①The remarkably effective rate was 75.81% and the effective rate was 91.94%% in the electronic moxibustion group,and the remarkably effective rate was 68.85% and the effective rate was 90.16% in the traditional moxibustion group. There was no significant difference between the two groups (P>0.05). The 95% confidence interval of the effective rate difference between the electronic moxibustion group and the traditional moxibustion group was -9.05－12.77. According to the 15% non-inferiority standard,the non-inferiority test was qualified.②There were significant differences in VAS scores between the two groups before and after 2 weeks and 4 weeks of treatment (P<0.01). But there was no significant difference in VAS score of knee pain between the two groups after 2 weeks and 4 weeks of treatment (P>0.05).③There were significant differences in total WOMAC score,pain score,rigidity score and activity difficulty score between the two groups before and after treatment for 2 weeks and 4 weeks (P<0.01). There was no significant difference in total WOMAC score,pain score,rigidity score and activity difficulty score between the two groups after 2 weeks and 4 weeks of treatment (P>0.05). ④There were no adverse reactions occurring in both groups. Conclusion:The clinical effect of electronic moxibustion apparatus (DZWJY-1) in the treatment of knee osteoarthritis is not inferior to that of traditional moxibustion therapy,which can obviously relieve pain and improve joint function.关键词：electronic moxibustion apparatus;knee arthritis;clinic trial;knee pain;knee joint function;standardization of moxibustion
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发布时间：2022-08-31 - 摘要：Objective:To observe the effect of catgut implantation at acupoint on glycolipid metabolism in patients of impaired glucose regulation (IGR) with abdominal obesity on the basis of lifestyle intervention or lifestyle intervention and metformin. MethodsA total of 160 IGR patients with abdominal obesity were randomly divided into four groups with 40 cases in each group.The group A took general dietary control and exercise advice.In addition to dietary control and exercise advice,metformin or catgut implantation at acupoint or combination of two treatments were administrated in the group B,C,D respectively. The course of treatment in each group was 6 months. The outcome was observed of IGR patients’ transition to the condition of diabetes mellitus (DM) or normal glucose tolerance (NGT) and the data were compared of the glycosylated hemoglobin (HbA1c),serum lipids (TC,TG,LDL-C,HDL-C),fasting blood glucose,plasma insulin,the relative indexes of liver function and the changes of waist circumference (WC),height and body mass level. The changes of insulin resistance index (HOMA-IR) and fatty liver index (FLI),) visceral fat index (VAI) were calculated and compared. Results:①A total of 156 patients completed the trial,including 40 cases in the group A,37 cases in the group B,40 cases in the group C and 39 cases in the group D. ②Compared with those before treatment,the levels of HbAlc,HOMA-IR,TG,LDL,WC,BMI and FLI were significantly decreased in the group B,C,D (P<0.05,P<0.01). The level of BMI,FLI in the group A was significantly lower than that before treatment (P<0.05),and only the level of VAI in the group C and D was decreased (P<0.05). Compared with the group A after treatment,the levels of HbA1c,TG were significantly lower in the group B,C and D (P<0.05,P<0.01) and the levels of WC,FLI,VAI were significantly lower in the group C and D (P<0.01). Only the level of HOMA-IR in the group D was significantly lower than that in the group A after treatment (P<0.01). The FLI,VAI of the group C and D were significantly lower than those of the group B after treatment (P<0.05,P<0.01).③ Comparing two groups after treatment,the incidence of IGR reverse to NGT in the group B,C and D was significantly higher than that in the group A (P<0.01),and the incidence of IGR conversion to DM in the group B,C and D was significantly lower than that in the group A (P<0.01). Compared with the group B,the incidence of IGR reverse to NGT in the group C and D was significantly higher (P<0.01),and the incidence of IGR conversion to DM in the group D was significantly lower(P<0.01).④There was no significant difference in the incidence of adverse reactions among the groups (P>0.05). Conclusion:Whether on the basis of lifestyle intervention or on the basis of lifestyle intervention and metformin,the catgut implantation at acupoint has a better regulating effect on glucose metabolism and pancreatic islet function in the treatment of IGR patients with abdominal obesity. At the same time,it can reduce abdominal obesity,the accumulation of visceral fat and hepatic fatty lesions,thereby preventing cardiovascular complications and reducing the incidence of diabetes.关键词：impaired glucose regulation;prediabetes;abdominal obesity;catgut implantation at acupoint;metformin;fatty liver index;visceral adipose index
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发布时间：2022-08-31 - 摘要：Objective:To observe the clinical and pathological effects of Weiqi Decoction on the treatment of chronic atrophic gastritis with qi deficiency and blood stasis. MethodsSixty-two patients with chronic atrophic gastritis with qi deficiency and blood stasis were randomly divided into treatment group (32 cases) and control group (30 cases). Both groups were given conventional treatment of Western medicine,but selenium yeast capsules and teprenone capsules were added into the control group on this basis and the treatment group was added with Weiqi Decoction. Both groups were treated for 3 months to observe the clinical efficacy and pathological changes,and to compare the changes of TCM syndrome scores. Results:① The total effective rate of the treatment group and the control group were 90.6% and 56.7% respectively,and the clinical efficacy of the treatment group was better than that of the control group (P<0.05). ②=2\*GB3After treatment,the scores of TCM syndromes in the two groups were decreased compared with those before treatment (P<0.05),and the difference of TCM syndromes between the two groups after treatment was statistically significant (P<0.05). ③=3\*GB3 The total effective rate of gland atrophy in the treatment group and the control group was 62.5% and 30.0%,and the total effective rate of intestinal metaplasia was 58.1% and 27.6%,respectively. The improvement of pathological changes in the treatment group was better than that in the control group (P<0.05). Conclusion:The effect of Weiqi Decoction on treating chronic atrophic gastritis with deficiency of qi and blood stasis is satisfactory. It can obviously improve the clinical symptoms of the patients and to some extent reverse the atrophy of the inherent glands of gastric mucosa and intestinal metaplasia.关键词：chronic atrophic gastritis;qi deficiency and blood stasis;Weiqi Decoction;gland atrophy;intestinal metaplasia
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发布时间：2022-08-31 - 摘要：Objective:To observe the clinical efficacy of Wenshen Buxu Decoction combined with levothyroxine sodium in the treatment of subclinical hypothyroidism (SCH) and its effect on blood lipids and related cytokine levels. MethodsA total of 86 SCH patients were randomly divided into treatment group and control group,43 cases in each group. The control group was treated with levothyroxine sodium tablets,and the treatment group was treated with Wenshen Bushu Decoction based on the treatment of the control group. The two groups were treated for 3 months. The clinical efficacy was observed and the interleukin-2 (IL-2),interleukin-10 (IL-10),interleukin-2 receptor (IL-2R) as well as the thyroid function related indicators including serum thyroid stimulating hormone (TSH),serum free triiodothyronine (FT3),serum free thyroxine (FT4),the blood lipids indexes including triglycerides (TG),total cholesterol (TC),high-density lipoprotein cholesterol (HDL-C),low-density lipoprotein cholesterol (LDL-C)]in the two groups were compared. Results:①The total effective rate of the treatment group had significantly statistical difference compared with that of the control group (93.02% vs 74.42%,P<0.05)；②After treatment,the TSH level was decreased (P<0.05),while the serum FT3 and FT4 levels were increased (P<0.05),with statistic difference between the two groups (P<0.05).③After treatment,the serum TG,TC and LDL-C levels were decreased (P<0.05),while the HDL-C level was increased (P<0.05),with statistic difference between the two groups (P<0.05).④After treatment,the serum IL-10 levels were increased (P<0.05),and the IL-2 and IL-2R levels were decreased (P<0.05),with statistic difference between the two groups (P<0.05). Conclusion:Compared with the single application of levothyroxine sodium,Wenshen Buxu Decoction combined with levothyroxine sodium can ameliorate the thyroid function and regulate the levels of blood lipids and related cytokines for SCH patients.关键词：SCH;levothyroxine sodium;Wenshen Buxu Decoction;blood lipid;IL-2;IL-10
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发布时间：2022-08-31 - 摘要：Objective:To observe the clinical effects of four acupoints with eight needles on treating hysteromyoma. MethodsAmong 98 patients with hysteromyoma,50 were divided into the treatment group and 48 were divide into the control group. Among the treatment group,the four acupoints,including Zusanli (ST 36),Yinlingquan (SP 9),Diji (SP 8) and Sanyinjiao (SP 6),with eight needles were used to treat the patients; among the control group,no acupoints and needles were used,just for comparison. After three months of treatment,measures were taken to observe clinical effects,symptom and sign scores as well as the tumor volume in the two groups. Results:①The total effective rate of the treatment group was 76.00%,and the control group 4.17%. The clinical efficacy between the groups had statistical significance (P<0.05). ②After treatment,hysteromyoma size was reduced in the treatment group(P<0.05),but there was no significant difference in the control group (P>0.05). The difference of reduced hysteromyoma size between the two groups had statistical significance (P<0.05). ③After treatment,there were significant differences in the total scores and sub-scores of symptoms and signs in the treatment group (P<0.05),but there was no significant difference in the control group (P>0.05). After treatment,there were significant differences in the total scores and the sub-scores of symptoms and signs between the two groups,which were significantly lower in the treatment group than in the control group (P<0.05). Conclusion:The clinical effect on hysteromyoma treated by the four acupoints with eight needles is satisfactory and it can significantly improve the clinical symptoms and signs of the patients and reduce the volume of the tumor.关键词：hysteromyoma;acupuncture;non-drug therapy;tumor volume
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发布时间：2022-08-31 - 摘要：Objective:To investigate the effect of Fructus Tribulus (TTL) on photoreceptor cell apoptosis and impaired retina in the mouse model of bright light-induced retinal degeneration. MethodsBALB/c mice were randomly divided into normal control group,bright light-exposed group and TTL-treated group. After dark adaptation for 24 h,bright light was applied at the intensity of 10 000 Lux for 30 min. Totally 100 μl of TTL decoction (100 mg per 20 g body mass) was intraperitoneally administered 30 min prior to bright light exposure in the TTL-treated group. The normal control group and the bright light-exposed group were intraperitoneally injected with the same amount of 0.9%NaCl solution. ①Eyes were enucleated 1 d and 3 d later and subjected to frozen section for the detection of apoptotic cells using TUNEL assay. ②The retinal function of mice was measured by electroretinogram (ERG) 6 d after bright light exposure. Results:①In the normal control group,TUNEL staining was negative in the photoreceptor cell nucleus of outer nuclear layer. Compared with the normal control group,the TUNEL positive photoreceptor cells in the outer nuclear layer of retina increased significantly on the 1st day and reached the peak at the 3rd day after light injury in bright light-exposed group(P<0.001). Compared with the bright light-exposed group,only a few scattered TUNEL positive photoreceptor cells were found in the outer nuclear layer in the TTL-treated group(P<0.05). ②ERG revealedthat the amplitudes of a-wave and b-wave were significantly depressed in the bright light-exposed group compared with those in the normal control group(P<0.05). In contrast,the amplitudes of a-wave and b-wave in TTL-treated group were significantly higher than those in the bright light-exposed group(P<0.05). Conclusion:sTribulus terrestris L. can significantly reduce photoreceptor cell apoptosis induced by light injury,and has protective effect on retinal function in mice.关键词：Fructus Tribuli;retinal degeneration;photoreceptor cell apoptosis;retinal function;mouse
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发布时间：2022-08-31 - 摘要：Objective:To study the treatment effect of a prescription of Chinese medicine which tonifies qi and removes toxicity on peripheral blood cytopenia and immune organs injury caused by 4 Gy 60Co γ ray in mice. MethodsA total of 120 Balb/c mice were randomly divided into two groups:the blank group and the irradiation group which were followed by whole-body exposure to 4 Gy 60Co γ ray. After irradiation,the irradiated mice were randomly divided into two groups:the model group and the Chinese medicine group. Mice of the blank and model groups were given deionized water by gavage once daily,while the others were administrated with the Chinese medicine. On the 14th,21th,35th,49th day of exposure,the mice were sacrificed respectively and the white blood cell (WBC),lymphocytes (LYMP),red blood cell (RBC),hemoglobin (HGB),blood platelets (PLT),thymus index,spleen index and spleen pathological section of each group were measured. Results:Compared with the blank group,the peripheral blood cell amount and immune organ index decreased significantly and the pathological changes of the spleen were obvious in the model group on 14th day of exposure. At day 21 after irradiation,all kinds of blood cells in the model group gradually increased,the spleen index returned to normal level,the thymus index decreased again,the pathological changes of the spleen were alleviated,and the pathological sections showed that the hematopoiesis was obvious outside the red pulp. At day 35 after irradiation,thymus index of the model group returned to normal level, and the RBC,HGB,PLT of the Chinese medicine group regained to normal level. At day 49 after irradiation,the RBC,HGB,PLT of the model group just returned to normal level and the spleen structure was close to normal,while the WBC,LYMP were still lower than those of the blank group. The WBC,LYMP of the Chinese medicine group had returned to normal level. Compared with the model group,14 days after irradiation,the spleen index of the Chinese medicine group increased significantly,and the pathological changes of the spleen were slight; on the 35th day after irradiation,the RBC and HGB of the Chinese medicine group were significantly increased; and the WBC of the Chinese medicine group significantly increased on the 49th day after irradiation. Conclusion:The prescription of Chinese medicine speeds up the recovery of peripheral blood cytopenia and immune organs injury after radiation in mice.关键词：irradiation;peripheral blood cytopenia;immune organs injury;prescription of Chinese medicine;treatment;mouse
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发布时间：2022-08-31 - 摘要：Objective:To observe the protective effect of the extract of Adiantum capillus-veneris L. on cardiac tissue of rat model with chronic mountain sickness (CMS). Method A total of 50 rats were randomly divided into different groups namely plain control group(CG),high altitude model group(MG),nifedipine positive control group(NE),alcohol group of Adiantum capillus-veneris L.(ACVL.AG) and water group of Adiantum capillus-veneris L.(ACVL.WG),with 10 rats in each group. Among them 40 rats were fed for 30 days under the CMS molding condition and then were given the medicine for 15 days after successful molding. The remaining 10 rats were fed under plain condition for 45 days. The changes of pulmonary artery pressure and cardiac histomorphology were observed and the serum indexes such as C-reaction protein(CRP),erythropoietin(EPO),vascular endothelial growth factor (VEGF) and apolipoprotein A1 (Apo-A1) were detected in rats. Results:Compared with the plain control group,the levels of PAP,CRP,EPO,VEGF in the high altitude model group,nifedipine positive control group,alcohol group of Adiantum capillus-veneris L. and water group of Adiantum capillus-veneris L. were increased (P<0.05) and level of Apo-A1 was decreased steadily (P<0.05),which suggest that hypoxia at high altitude can damage the heart tissue of rats. Compared with the high altitude model group,the levels of CRP,EPO and VEGF were decreased (P<0.05) and the level of Apo-A1 was increased (P<0.05) in the alcohol group of Adiantum capillus-veneris L. and water group of Adiantum capillus-veneris L.. At the same time,pathological changes of heart tissue were observed in CMS model rats under light microscope. The heart histomorphology was significantly improved after the intervention of the extract of Adiantum capillus-veneris L.. Conclusion:The extract of Adiantum capillus-veneris L. has protective effect on the heart of CMS rat model.
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发布时间：2022-08-31 - 摘要：Objective:To study the effects of Ruyiping on the proliferation and invasion of MDA-MB-231 cells and its mechanism. MethodsMDA-MB-231 cells were treated with Ruyiping. The proliferation ability was detected by MTT and the invasion ability was detected by Transwell experiment. The expression of E-Cadherin was also detected by real-time PCR and Western blot in MDA-MB-231 cells after Ruyiping and NF-κB inhibitor stimulation. Results:Ruyiping slightly inhibited MDA-MB-231 proliferation and significantly suppressed the migration of tumor cells by inducing E-Cadherin expression through NF- κB pathway. Conclusion:Ruyiping can inhibit the proliferation and migration of MDA-MB-231 cells and its mechanism may be related to the promotion of E-Cadherin expression.
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发布时间：2022-08-31 - 摘要：Objective:To investigate the extraction process of Ningshen Granules. MethodsOrthogonal test was used to investigate the effects of solid-liquid ratio,extraction time,and times on extraction process. The extraction process was optimized by comprehensive evaluation indexes based on the content of 2,3,5,4′-tetrahydroxy stilbene-2-O-β-D-glucoside,naringin,salvianolic acid B,and the extraction yield. Results:According to the result of comprehensive score,the optimal extraction conditions of this preparation were as follows:extracted three times with 8 times of water quantity,each for 0.5 h. Conclusion:This optimized process is simple,feasible,repeatable.关键词：Ningshen Granule;orthogonal experiment;2,3,5,4′-tetrahydroxy stilbene-2-O-β-D-glucoside;naringin;salvianolic acid B;comprehensive evaluation of multiple mark
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发布时间：2022-08-31 - 摘要：Objective:To investigate the anti-inflammatory and analgesic effects of Daphnis Cortex enteric-coated preparation on adjuvant arthritis rats. MethodsThe rat model of adjuvant arthritis was established by intradermal injection of Freund’s complete adjuvant. The rats were divided into the control group,model group,prednisone group,and low,middle and high dose groups of Chinese medicine, 12 rats in each group. The prednisone group was given prednisone 3.2 mg/kg by gavage,and the low,middle and high dose groups of Chinese medicine were given the medicine 0.396 g/kg,0.792g/kg,1.584 g / kg,respectively by gavage. The control group and the model group were given the same volume of 7.5% CMC-Na solution. After continuous intervention for 12 days,the swelling rate of voix pedis,the 50% mechanical withdrawal threshold (MWT) and thermal withdrawal threshold (TWT) were calculated on the 7th and 12th day after modeling. The serum levels of interleukin-6 (IL-6),prostaglandin E2 (PGE2) and tumor necrosis factor- α (TNF- α) were measured by ELISA 24 hours after the last administration. The pathological changes were observed by HE staining in the knee and ankle joints of the rats. Results:①Compared with the control group,the swelling rate of voix pedis in the model group was higher than that in the model group (P<0.01) and the value of 50%MWT,TWT was decreased (P<0.01) but the levels of IL-6,PGE2,TNF- α in serum were decreased (P<0.01). ② Compared with the model group,the swelling rate of voix pedis was decreased (P<0.01),the 50% MWT and TWT were increased (P<0.01),and the levels of the serum IL-6,PGE2,TNF- α were decreased in the prednisone group,and in the low,middle and high dose groups of Chinese medicine (P<0.01). ③ There was no significant difference among prednisone group and Chinese medicine groups in the above indicators (P>0.05). Conclusion:Daphne Cortex enteric-coated preparation has obvious anti-inflammatory and analgesic effects. It can significantly improve the pathological damage of knee joint and ankle joint in rats with adjuvant arthritis.关键词：Daphnes Cortex;adjuvant arthritis;rat;anti-inflammatory;analgesic
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发布时间：2022-08-31 - 摘要：This review summarizes the research progress of Herba Epimedii and its main components in regulating AMPK pathway in the treatment of heart failure. It has been found that Epimedium can prevent heart failure by regulating different targets in the AMPK pathway:activate AMPK to promote energy generation through regulation of the PGC-1α and PPARα expression; and regulate the expression of GLUT4 and ACC to optimize substrate metabolism and stimulate energy generation. It also can inhibit ROS production and increase ATPase activity to improve energy utilization.关键词：Herba Epimedii;heart failure;AMPK;energy metabolism;review
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发布时间：2022-08-31 - 摘要：To review the research progress of anti-tumor mechanism of Fructus Brucea Modern research has found that Fructus Brucea has a wide range of anti-cancer effects,which can inhibit cell proliferation,induce apoptosis,inhibit tumor metastasis and angiogenesis,and enhance chemotherapy.关键词：Fructus Brucea;tumor;pharmacology of traditional Chinese medicine;mechanism;review
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发布时间：2022-08-31
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