最新刊期
期 8 ， 2018
- 摘要：This paper summarizes Professor Qiu Jianxing’s experience in the treatment of irritable bowel syndrome with syndrome of dampness-heat stagnating in intestine. It is considered that the majority of patients with syndrome of dampness-heat stagnating in intestine are in Lingnan area. The therapy of clearing intestines and promoting diuresis,invigorating spleen and benefiting qi should be applied as principle,and Huofeng Qingchang Decoction is created as recipe. One proven case is presented.关键词：irritable bowel syndrome;dampness-heat stagnating in intestine;Huofeng Qingchang Decoction;experience of famous doctor;Qiu Jianxing
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发布时间：2022-08-31 - 摘要：“Clear” state is the fundamental guarantee for the health, and “non clear” state of the body can lead to the tumor. The importance of “clear” state in the prevention and treatment of tumor is explained from “clear orifices”, “clear qi” and “clear spirit” and so on. It is considered that the “clear” state of the body is the guarantee of realizing correspondence between nature and human and maintaining harmony between body and spirit. It is the foundation of the orderly store and discharge of zang-fu organs and the smooth flow of qi,blood and meridians. It is also the key to dispelling pathogens and attacking toxin out of the body and preventing the formation of cancer.关键词：tumor;clear;treatment principle;prevention and treatment
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发布时间：2022-08-31 - 摘要：This article discusses the etiology, pathology, syndrome and treatment of dysmenorrhea due to depression syndrome. Internal injury caused by excess seven emtions can cause qi and blood failing to transport and menstrual blood stasis of meridians, all of these lead to dysmenorrhea. Stagnation of liver qi and liver fire is the cause of dysmenorrhea due to depression syndrome. All pain originate from heart and the five minds affect heart, the dysfunction of heart governing blood and vessels can cause disorders of blood and qi and induce dysmenorrhea. The clinical manifestations of dysmenorrhea are often accompanied by emotional disorders and/or a series of physical symptoms. The treatment principle for dysmenorrhea due to depression syndrome is symptomatic treatment in acute condition to relieve pain and radical treatment in chronic case to relieve depression. Stagnation and deficiency may cause the pain, and the pain could be alleviated after dredging and nourishing. When there is stagnation, the pain could be felt; and when the stagnation is resolved, the pain could be eliminated. In the treatment of dysmenorrhea due to depression syndrome, prevention is more important than treatment.关键词：depression syndrome;dysmenorrhea;etiology and pathology;clinical characteristics;treatment principle
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发布时间：2022-08-31 - 摘要：Objective:To study Chen Yiping’s medication rules in the treatment of idiopathic membranous nephropathy (IMN) based on data mining. MethodsThe information and prescriptions of outpatient cases with IMN treated by Chen Yiping were collected and analyzed by complex network toolbox. The relevance was evaluated by mutual information method based on information entropy, and the significant threshold of correlation degree was automatically determined by random permutation test. Based on those above, the complex network was established to measure the importance of relationship between drugs through support and confidence degree, and explore the core couplet medicines through association rules. Results:①218 cases informations were collected, and 613 prescriptions were extracted, which including 198 medicines, and the accumulated usage frequency was 10 140 times. ②There were 21 medicines with usage frequency more than 60 times, including Baizhu (Atractylodis Macrocephalae Rhizoma), Huangqi (Astragali Radix), Danggui (Angelicae Sinensis Radix), Cangzhu (Atractylodis Rhizoma ), Shanyao (Dioscoreae Rhizoma), Fuling (Poria), Zhuling (Polyporus), BaihuaSheshecao (Hedyotis Herba), Jiangcan (Batryticatus Bombyx), Yiyiren (Coicis Semen), Danshen (Salviae Miltiorrhizae Radix et Rhizoma), Dangshen (Codonopsis Radix), Banzhilian (Scutellariae Barbatae Herba), Furongye (Hibisci Mutabilis Folium), Jinying (Rosae Laevigatae Fructus), Gouji (Cibotii Rhizoma), Yinyanghuo (Epimedii Folium), Tusizi (Cuscutae Semen), Gegen (Puerariae Lobatae Radix), Chuanxiong (Chuanxiong Rhizoma) and Chonglou (Paridis Rhizoma), which can be taken as the basic drugs in Professor Chen Yiping’s treatment on IMN. Among these drugs, the usage frequency of Baizhu, Huangqi, Danggui, Cangzhu, Shanyao and Fuling was over 90%, which can be considered as core medicines. ③The usage frequency of qi-supplementing medicines, heat-clearing medicines, medicines for diuresis and diffusing dampness, medicines for activating blood and removing blood stasis and dampness resolving medicines was higher. ④According to the association rules analysis, 627 couplet medicines were achieved, and 24 of them were considered as core couplet medicines with AVCH>1. Meanwhile, 4 basic prescriptions were achieved by BK algorithm. Conclusion:Professor Chen Yiping’s treatments for IMN focus on spleen deficiency and dampness-heat and blood stasis blocking vessels and meridians, and the therapies of benefiting qi and clearing heat, inducing diuresis and eliminating dampness, promoting blood circulation for removing blood stasis are applied. The core medicines are Baizhu, Huangqi, Danggui, Cangzhu, Shanyao and Fuling, 24 core couplet medicines and 4 basic prescriptions are made.关键词：idiopathic membranous nephropathy;medication rule;data mining;Chen Yiping
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发布时间：2022-08-31 - 摘要：Based on the proven cases, this paper analyzes Professor Jiang Jian’s clinical experience in treating exfoliative cheilitis. It is considered that the pathogenesis of exfoliative cheilitis is exogenous wind-dryness-heat-toxin and internal dampness-heat in spleen and stomach. Chinese medicines by oral administration combined with external application are made good used to treat exfoliative cheilitis. The commonly used drugs include wind-heat dispersing medicine, heat-clearing and detoxicating (dampness-drying) medicine, spleen-activating and dampness-resolving medicine, yin-tonifying and dryness-moistening medicine.关键词：exfoliative cheilitis;clearing heat and activating spleen;experience of physician;Jiang Jian
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发布时间：2022-08-31 - 摘要：This paper discusses Zhu Xueping’s experience in treating uric acid nephropathy with therapy of strengthening vital qi and eliminating turbidity combined with pathological stage. It is considered that the key of the disease is the formation of uric acid crystals. And the core of pathogenesis is "turbidity". The disease should be treated with the therapy of strengthening vital qi and eliminating turbidity,and disease differentiation and treatment by stages should be performed according to the pathological changes. One proven case is presented.关键词：uric acid nephropathy;therapy of strengthening vital qi and eliminating turbidity;experience of famous doctor;Zhu Xueping
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发布时间：2022-08-31 - 摘要：From the prescriptions described in the relevant context of Shanghan Lun(Treatise on Cold Pathogenic Diseases),this paper discusses the treatment methods for depression. It can be divided into six methods of Chinese medicinal materials,including关键词：depression;classical prescription;Baihe(Lilii Bulbus);Dihuang(Rehmanniae Radix);Guizhi(Cinnamomi Ramulus);Chaihu(Bupleuri Radix);Zhizi(Gardeniae Fructus);Fuzi(Aconiti Lateralis Preparata Radix)
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发布时间：2022-08-31 - 摘要：The meaning of “beside the seventh thoracic vertebra, there is a small heart” in Huangdi Neijing (Inner Canon of Huangdi) is discussed. Combined with the chapters of Gudu (Bone Measurement) in Lingshu (Miraculous Pivot), Beishu (Back-Shu Acupoints) in Lingshu, Cire in Suwen (Plain Questions) and other chapters, the meaning of the seventh thoracic vertebra is explained. It is considered that the “kidney acupoint” is the “seventh section” starting from the “phrenic acupoint”. Meanwhile, according to the symmetrically expression and figurative metaphor at the beginning of Cijin Lun in Suwen, it finds that the “small heart” refers to the two kidneys.关键词：Huangdi Neijing (Inner Canon of Huangdi);seventh thoracic vertebra;small heart;kidney
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发布时间：2022-08-31 - 摘要：Based on ancient medical writings and modern medical knowledge, this paper summarizes and analyzes the anatomical features, physiological significance and pathological changes of “screen gate” of seven important portals. It is considered that screen gate belongs to the small intestine and is one of the five orifices of stomach. It is closely related to the spleen and stomach. It shows the function of timely open and close, and helps the small intestine to separate clear and excrete turbid, which plays an important role in the digestion and absorption of food and drink and the excretion of dregs. There may be pathological changes such as fu organs failing to transport and clear, heat obstructing intestines, disorder of clear and turbid, and the treatment on pathological changes is aimed at restoring the function of screen gate.关键词：Nanjing;seven important portals;screen gate;small intestine;spleen and stomach
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发布时间：2022-08-31 - 摘要：Objective:To observe the clinical efficacy of Qiyeling Decocotion combined with routine western medicine therapy in treating radiation pneumonitis. Methods80 patients with radiation pneumonitis were randomly divided into the control group and observation group, 40 cases in each group. The control group was treated with routine western medicine therapy and the observation group was orally treated with Qiyeling Decocotion based on the treatment for the control group, with a course of 2 months. The clinical efficacy was observed, the traditional Chinese medicine (TCM) syndrome scores, FACT-G scores, serum inflammatory factors including transforming growth factor-β1 (TGF-β1), tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6), and pulmonary function indexes were compared. Results:①The total effective rates were 80.0% in the observation group and 67.5% in the control group, the clinical efficacy of the observation group was better than that of the control group (P<0.05). ②Compared with treatment before, the scores of cough, expectoration, soreness of waist and weakness of legs, dizziness and tinnitus were decreased in the observation group after treatment (P<0.05), the scores of cough and expectoration were decreased in the control group after treatment (P<0.05).After treatment, the improvement on TCM syndrome in the observation group was better than that in the control group (P<0.05). ③Compared with treatment before, the FEV1/FVC% and FEV1% were increased in both groups after treatment (P<0.05), the FVC in the observation group was also increased after treatment (P<0.05). After treatment, the FVC, FEV1/FVC% and FEV1% in the observation group were higher than those in the control group (P<0.05). ④After treatment, the physiological status score, function status score and the total score of FACT-G scale were increased in the observation group compared with treatment before (P<0.05). The physiological status score, social or family status score, function status score and the total score of scale in the observation group were higher than those in the control group (P<0.05). ⑤After treatment, the serum levels of TGF-β1, TNF-α and IL-6 were decreased in the observation group compared with treatment before (P<0.05). After treatment, the serum levels of TGF-β1, TNF-α and IL-6 in the observation group were lower than those in the control group (P<0.05). Conclusion:Qiyeling Decoction combined with routine western medicine therapy shows satisfactory efficacy in treating radiation pneumonitis, which can obviously ameliorate the clinical symptoms and pulmonary function of patients, control the inflammatory response and improve the quality of life.关键词：radiation pneumonitis;Qiyeling Decoction;pulmonary function;quality of life;cytokines
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发布时间：2022-08-31 - 摘要：Objective:To observe the clinical efficacy of Renshen Wuweizi Decoction in the treatment of spleen deficiency syndrome due to recurrent respiratory infection in children. Methods178 children patients with spleen deficiency syndrome due to recurrent respiratory infection were randomly divided into the treatment group and control group,89 cases in each group. The control group was treated with Mamiai Particles(combined bacillus subtilis and enterococcus faecium granules with multivitamines),and the treatment group was treated with Renshen Wuweizi Decoction based on the treatment for the control group,with a course of four weeks. The clinical efficacy was observed,and the TCM syndrome score,the levels of blood routine examination indexes and C reactive protein (CRP) were compared. Results:①=1\*GB3The total effective rates were 97.8% in the treatment group and 94.4% in the control group. There was statistically significant difference on the clinical efficacy between the two groups(P＜0.05). ②Compared with treatment before,the TCM syndrome score was decreased in both groups after treatment(P＜0.05). After treatment,the TCM syndrome score of the treatment group was lower than that of the control group (P<0.05). ③In both groups,there were statistically significant differences on the levels of WBC,Hb and CRP between treatment before and after(P＜0.05),and the EOS level in the treatment group was increased after treatment(P＜0.05). After treatment,there were statistically significant differences on the levels of Hb and CRP between the two groups(P＜0.05). Conclusion:Renshen Wuweizi Decoction shows good efficacy in the treatment of spleen deficiency syndrome due to recurrent respiratory infection in children,which can improve the clinical symptoms of patients.关键词：recurrent respiratory infection in children;spleen deficiency syndrome;Renshen Wuweizi Decoction;intestinal microflora
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发布时间：2022-08-31 - 摘要：Objective:To observe the clinical efficacy and safety of Chinese medicated diet based on routine therapy in the treatment of diabetic foot ulcer combined with hypoalbuminemia. Methods77 patients with diabetic foot ulcers and hypoproteinemia were randomly divided into the treatment group (39 cases) and control group (38 cases). Both groups were treated with routine therapy and diabetes diet. Additionally, the control group was treated with compound amino acid capsules and the treatment group was treated with Huangqi Zhuti Decoction, with a course of 1 month. The wound healing efficacy and medication safety were observed. The wound area, nutritional risk index (NRI) and serum nutriology related indexes such as total protein (TP), albumin (Alb), prealbumin (PA) and hemoglobin (Hb) were compared. Results:①There were statistically significant differences on the levels of TP, Alb, PA and Hb in the treatment group between treatment before and after (P<0.05). After treatment, the levels of TP, Alb, PA and Hb in the treatment group were obviously higher than those in the control group (P<0.05). ②There was statistically significant difference on the NRI level in the treatment group between treatment before and after (P<0.05). After treatment, the NRI level in the treatment group was obviously higher than that in the control group (P<0.05). ③There was statistically significant difference on the wound area in both groups between treatment before and after (P<0.05). After treatment, the wound area in the treatment group was obviously smaller than that in the control group (P<0.05). ④The total effective rates of wound healing were 82.1% in the treatment group and 52.6% in the control group, the wound healing efficacy of the treatment group was obviously better than that of the control group, with statistically significant difference (P<0.05). ⑤There were no statistically significant differences on the levels of triacylglycerol, total cholesterol, fasting blood glucose and postprandial 2 h blood glucose in both groups between treatment before and after (P>0.05). There were also no statistically significant differences on the levels of liver and kidney function indexes including total bilirubin, direct bilirubin, alanine transaminase, aspartate aminotransferase, creatinine, urea nitrogen and uric acid in both groups between treatment before and after (P>0.05). Conclusion:Chinese medicated diet based on the routine therapy in the treatment of diabetic foot ulcer combined with hypoalbuminemia can obviously improve the nutritional status of patients, and promote the wound healing, which shows good safety and no effects on the blood glucose, blood lipid and liver and kidney function.关键词：diabetic complication;foot ulcer;hypoproteinemia;Chinese medicated diet;Huangqi Zhuti Decoction;Danggui Buxue Decoction
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发布时间：2022-08-31 - 摘要：Objective:To discuss the clinical efficacy of Uric acid-reducing Decoction combined with allopurinol in the treatment of uric acid nephropathy with syndrome of qi deficiency of spleen and kidney and dampness-heat accumulated in interior. MethodsSixty patients of uric acid nephropathy with syndrome of qi deficiency of spleen and kidney and dampness-heat accumulated in interior were randomly divided into the treatment group and control group, 30 cases in each group. Both groups were orally treated with allopurinol tablets, and the treatment group was additionally treated with Uric acid-reducing Decoction, with a course of 28 days. The clinical efficacy was observed. The changes on uric acid, creatinine and urea nitrogen levels in serum, glomerular filtration rate, urinary β2 microglobulin, N-acetyl-β-D glucosaminidase and 24 h urine protein quantity were compared. Results:①The total effective rates were 80.0% in the treatment group and 50.0% in the control group, the clinical efficacy of the treatment group was better than that of the control group (P<0.05). ②Compared with treatment before, the levels of serum uric acid, serum creatinine, urinary β2 microglobulin, N-acetyl-β-D glucosaminidase and 24 h urine protein quantity were decreased (P<0.05) and the glomerular filtration rate was obviously increased (P<0.05) in the treatment group, while only the serum level of uric acid was decreased in the control group (P<0.05) after treatment. There were statistically significant differences on above indexes between the two groups after treatment (P<0.05). Conclusion:Uric acid-reducing Decoction combined with allopurinol in the treatment of uric acid nephropathy with syndrome of qi deficiency of spleen and kidney and dampness-heat accumulated in interior can not only significantly decrease the serum level of uric acid, but also improve the glomerular filtration function and renal tubule repair function, and reduce the proteinuria level.关键词：uric acid nephropathy;therapy of integrated traditional Chinese and western Medicine;Uric acid-reducing Decoction;allopurinol;serum uric acid
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发布时间：2022-08-31 - 摘要：Objective:To observe the clinical efficacy of self-made Shugan Tongfu Decoction in the treatment of functional constipation due to qi stagnation. Methods120 patients with functional constipation due to qi stagnation were randomly divided into the observation group and control group, 60 cases in each group. The control group was treated with lactulose and the observation group was treated with self-made Shugan Tongfu Decoction, with a course of one month. The clinical efficacy was observed. The changes on traditional Chinese medicine (TCM) syndrome scores (including difficult in defecation, abdominal swelling pain, belching, distention and fullness in chest and hypochondrium, borborygmus and less food intake) and the interval time of defecation were compared. Results:The total effective rates were 91.7% in the observation group and 78.3% in the control group, the clinical efficacy of the observation group was better than that of the control group (P<0.05). After treatment, except the less food intake, all the TCM syndrome scores and the interval time of defecation were reduced in both groups compared with treatment before (P<0.05). After treatment, there were statistically significant differences on all the TCM syndrome scores and the interval time of defecation between the two groups (P<0.05). Conclusion:The self-made Shugan Tongfu Decoction shows exact efficacy in treating functional constipation due to qi stagnation, which can effectively improve the clinical symptoms of patients and is worthy of clinical promotion.关键词：functional constipation;qi stagnation;therapy of traditional Chinese medicine;self-made Shugan Tongfu Decoction
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发布时间：2022-08-31 - 摘要：Objective:To observe the effects of Taohong Siwu Decoction on the bone mineralization in the process of bone transport. Methods40 postoperative patients with traumatic bone defect of extremities or osteomyelitis of extremities who need to be performed the bone transport surgery were randomly divided into the treatment group and control group, 20 cases in each group. The patients in the two groups were performed the bone transport surgery. The control group was treated with the routine symptomatic measures, the treatment group was treated with Taohong Siwu Decoction based on the treatment for the control group, with a course of 3 months. The time of fracture healing and bone mineralization was observed. The bone density of the lengthened bone segments and VAS score for the affected limb pain were compared. Results:①Compared with one month after bone transport, there was statistically significant difference on the BMD level of the lengthened bone segments in both groups at all the time points after that, and the BMD level was significantly increased (P<0.05). Four months after bone transport, at the end of bone transport and bone mineralization, there was statistically significant difference on the BMD level of the lengthened bone segments between the two groups, and the BMD level in the treatment group was significantly higher than that in the control group (P<0.05). ②Compared with the first day after bone transport, there was statistically significant difference on the VAS score in both groups at all the time points after that, and the VAS score was significantly decreased (P<0.05). One week after bone transport, one month after bone transport, at the end of bone transport and bone mineralization, there was statistically significant difference on the VAS score between the two groups, and the VAS score in the treatment group was significantly lower than that in the control group (P<0.05). ③The fracture healing time and bone mineralization time in the treatment group were obviously less than those in the control group, with statistically significant differences (P<0.05). Conclusion:Taohong Siwu Decoction can obviously increase the bone density of lengthened bone segments in the process of bone transport, relieve the pain symptoms of the affected limb in the process of bone transport and fracture healing, shorten the time of fracture healing and bone mineralization.关键词：bone defect;fracture;bone transport;bone mineralization;healing;Taohong Siwu Decoction;promoting blood circulation for removing blood stasis
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发布时间：2022-08-31 - 摘要：Objective:To observe the clinical efficacy of acupotomy combined with external application of Xiaoyu Powder in the treatment of knee osteoarthritis. Methods111 patients with knee osteoarthritis were randomly divided into the treatment group (55 cases) and control group (56 cases). The treatment group was treated with acupotomy combined with external application of Xiaoyu Powder, the control group was treated with external application of Votalin emulsion, with a course of 2 weeks. The knee joint function related scores including Lysholm score and WOMAC score, knee joint pain score (VAS score), knee joint swelling degree and mobility were evaluated. The medication safety was observed. Results:①Finally 50 cases in the treatment group and 50 cases in the control group completed the trial. ②Compared with treatment before, the Lysholm score was increased in both groups one month and three months after treatment (P<0.05), while the WOMAC score and VAS score were significantly decreased (P<0.05). One month and three months after treatment, the Lysholm score in the treatment group was obviously higher than that in the control group (P<0.05), while the WOMAC score and VAS score were significantly lower than those in the control group (P<0.05). ③Compared with treatment before, the knee joint swelling degree in the treatment group was obviously alleviated (P<0.05), while the range of flexion was obviously increased (P<0.05) one month and three months after treatment. One month and three months after treatment, the knee joint swelling degree in the treatment group was obviously slighter than that in the control group (P<0.05), while the range of flexion was obviously greater than that in the control group (P<0.05). ④There was no statistically significant difference on incidence rate of adverse reactions between the two groups (P>0.05). Conclusion:Acupotomy combined with external application of Xiaoyu Powder in the treatment of knee osteoarthritis can obviously alleviate the pain and swelling of knee joint, and improve the mobility.关键词：knee osteoarthritis;acupotomy;Xiaoyu Powder;Votalin emulsion;Wei’s traumatology
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发布时间：2022-08-31 - 摘要：Objective:To observe the clinical efficacy of hot compress of Chinese medicine combined with acupuncture and tuina and compound chlorzoxazone tablets on the axial symptoms of patients after cervical vertebra operation. Methods64 patients with axial symptoms after cervical vertebra operation were randomly divided into treatment group and control group,32 cases in each group. Both groups were orally treated compound chlorzoxazone tablets,meanwhile the treatment group was treated with hot compress of Chinese medicine,acupuncture and tuina,with a course of 14 days. The changes on JOA score,VAS score and axial symptoms score were observed. Results:①In both groups,there were statistically significant differences on JOA score and VAS score between treatment before and after(P<0.05). After treatment,there were statistically significant differences on JOA score and VAS score between the two groups(P<0.05). ②In both groups,there was statistically significant difference on axial symptoms score between treatment before and after(P<0.05). After treatment,there was statistically significant difference on axial symptoms score between the two groups(P<0.05). Conclusion:Compared with compound chlorzoxazone tablets alone,hot compress of Chinese medicine combined with acupuncture and tuina and compound chlorzoxazone tablets can better improve the neck and shoulder axial symptoms such as pain and stiffness after cervical vertebra surgery.关键词：after cervical vertebra operation;axial symptoms;therapy of integrated Chinese and western medicine;hot compress of Chinese medicine;acupuncture;Tuina
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发布时间：2022-08-31 - 摘要：Objective:To observe the clinical efficacy of Zhu’s Bushen Huoxue Prescription combined with standard western medicine in the treatment of recurrent spontaneous abortion combined with antiphospholipid syndrome (APS-RSA). Methods98 patients with APS-RSA with Syndrome of kidney deficiency and blood stasis were randomly divided into the treatment group and control group, 49 cases in each group. The control group was treated with standard western medicine therapy, the treatment group was treated with Bushen Huoxue Prescription based on the treatment for the control group. The pregnancy outcome was observed, including successful delivery and spontaneous abortion. The changes on antiphospholipid antibody (anti β2-GP1 antibody) and coagulation indexes (D-Dimer and platelet aggregation rate) were compared. Results:①Finally 40 cases in the treatment group and 40 cases in the control group completed the trial. ②According to the follow-up, there were 36 cases of successfully delivery and 4 cases of spontaneous abortion in the treatment group, there were 29 cases of successfully delivery and 11 cases of spontaneous abortion in the control group. The live birth rate of the treatment group was obviously higher than that of the control group (P<0.05). ③Compared between treatment before and pregnancy for 12 weeks, there were statistically significant differences on the anti β2-GP1 level and platelet aggregation rate in the treatment group (P<0.05), while no statistically significant difference was observed on the D-D level (P>0.05); there was statistically significant difference on the anti β2-GP1 level in the control group (P<0.05), while no statistically significant differences were observed on the platelet aggregation rate and D-D level (P>0.05). After treatment, the anti β2-GP1 level and platelet aggregation rate in the treatment group were obviously lower than those in the control group, with statistically significant differences (P<0.05). Conclusion:Zhu’s Bushen Huoxue Prescription combined with standard western medicine therapy can obviously improve the live birth rate of patients with APS-RSA, its mechanism may be related to improving the blood coagulation and regulating the related immune antibodies.关键词：antiphospholipid syndrome;recurrent spontaneous abortion;Bushen Huoxue Prescription;Zhu Nansun;clinical observation
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发布时间：2022-08-31 - 摘要：This paper discusses the differentiation and treatment of traditional Chinese medicine on urticaria based on the theory of “essence stored ensuring no occurrence of warm disease in spring”. It is considered that the pathogenesis of this disease is insufficiency of kidney essence,attack of wind-heat,internal and external interaction,syndrome involving both weifen and yingfen. The basic treatment principle should be reinforcing kidney for replenishing essence,dispersing wind-heat,cooling nutritive qi and promoting eruption. One proven case is presented.关键词：Urticaria;spring warm diseases;reinforcing kidney for replenishing essence;dispersing wind-heat;cooling nutritive qi and promoting eruption
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发布时间：2022-08-31 - 摘要：Objective:To observe the effects of celastrol (CSL) on the angiogenesis after cerebral ischemia, and discuss its neuroprotection effects after cerebral ischemia. Methods80 SD rats were randomly divided into the 24 h-treatment group and 7 d -treatment group, then sub-divided into the sham operation group, reagent control group, CSL groups with low- (0.5 mg/kg), middle- (2 mg/kg) and high-dose (5 mg/kg), 8 rats in each group. The sham operation group was performed the operation but without the ischemia state. The rat model of middle cerebral artery occlusion was established in the other groups. The first-time intragastric administration was conducted after ischemia for 90 minutes and reperfusion for 30 minutes, and the rats were treated with CSL at corresponding dose once a day. The rat behavior was evaluated and the brain tissue section staining was used to evaluate the degree of cerebral ischemia reperfusion injury in rats. The IL-1β content in brain tissue was detected, and the change on cell apoptosis rate was observed. The microvessel density of cerebral cortex was observed by immunohistochemical staining, and the contents of vascular endothelial growth factor (VEGF) and matrix metalloproteinase-9 (MMP-9) were detected by ELISA. Results:①There were statistically significant differences on all indicators between the intervention group and the corresponding sham operation group(P<0.05). ②For the comparison of neurological function score, infarct volume, apoptosis rate and VEGF and MMP-9 levels, at the same timepoint, there were statistically significant differences between the reagent control group and CSL groups with middle- and high-dose(P<0.05), and there were statistically significant differences between the middle- and high-dose group(P<0.05). ③Compared with the reagent control group at the same timepoint, the positive rate of CD31 was decreased in the CSL groups with middle- and high-dose(P<0.05). For the comparison between 24 h-treatment group and 7 d-treatment group, there was statistically significant difference on the positive rate of CD31 in the CSL groups with middle-and high-dose(P<0.05). ④In the 7 d-treatment groups, there was statistically significant difference on IL-1β level between the reagent control group and CSL groups with different doses(P<0.05). In the 24 h-treatment groups and 7 d -treatment groups, there was statistically significant difference on IL-1β level among the different doses groups(P<0.05). Conclusion:Within certain dose, there are opposite effects of CSL on cerebral ischemia-reperfusion in acute period, that is the neuroprotection and the inhibition on angiogenesis through anti-inflammation and anti-apoptosis. And its inhibitory effect on angiogenesis may be more significant over time. In the acute period of cerebral ischemia, the effects of CSL in inhibiting inflammatory factors and alleviating cell apoptosis are dominant, which is not affected by its inhibition on angiogenesis.关键词：celastrol;rat;cerebral ischemia;angiogenesis;neuroprotection
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发布时间：2022-08-31 - 摘要：Objective:To observe the protective effects of Hezhong Jianpi Decoction on the esophageal mucosal injury in rats with mixed reflux esophagitis and its effects on nuclear transcription factor-кB (NF-кB) signaling pathway, which mediated the inflammatory response. MethodsSixty healthy male SD rats of SPF grade were randomly divided into the normal group, sham operation group, model group, Hezhong Jianpi Decoction group and omeprazole group according to the random number table, 12 rats in each group. The rat model of mixed reflux esophagitis was established. 3 days after modeling, the rats were treated the corresponding drug by intragastric administration for 14 days. The histopathological changes of esophageal tissues were observed and scored. Meanwhile, the serum levels of interleukin-6 (IL-6), IL-8 and NF-кB p65 were detected. Results:The naked eye and pathological scores of esophageal mucosal and the serum expressions of NF-кB p65, IL-6, and IL-8 in the model group were significantly higher than those in the normal group, sham operation group, Hezhong Jianpi Decoction group and omeprazole group (P<0.05). There were no statistically significant differences on the naked eye and pathological scores of esophageal mucosal between the Hezhong Jianpi Decoction group and the omeprazole group (P>0.05). The serum expressions of NF-кB p65, IL-6, and IL-8 in the Hezhong Jianpi Decoction group were higher than those in the omeprazole group (P<0.05). Conclusion:Hezhong Jianpi Decoction can reduce the pathological damage degree of esophageal mucosa in rats with reflux esophagitis. Its mechanism may be related to down-regulating the serum expression levels of proinflammatory cytokines IL-6, IL-8 and NF-кB p65 in model rats, and thus relieving the esophageal inflammatory response to exert anti-inflammatory effects.关键词：Hezhong Jianpi Decotion;reflux esophagitis;nuclear transcription factor-κB;IL-6;IL-8;rat
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发布时间：2022-08-31 - 摘要：Objective:To observe the effects of Buyang Huanwu Decoction, Shaofu Zhuyu Decoction and Danshen Drink on the biological characteristics of erythrocyte membrane in hyperlipidemia rats, and clarify the target and mechanism of three prescriptions on the erythrocyte membrane in hyperlipidemia. MethodsNinety SD rats, male and female in half, were randomly divided into the Buyang Huanwu Decoction groups with high (14.0 g crude drug·kg-1) and low-dose (3.6 g crude drug·kg-1), Danshen Injection groups with high- (3.6 g crude drug·kg-1) and low-dose (0.9 g crude drug·kg-1), Shaofu Zhuyu Decoction groups with high-(4.8 g crude drug·kg-1) and low-dose (1.2 g crude drug·kg-1), positive control simvastatin group (2.0 mg·kg-1), model group and blank group. The rat model of hyperlipidemia was replicated by intragastric administration of fat emulsion for 20 days. Then each group was treated with the corresponding drug treatment for 10 days, meanwhile, the fat emulsion treatment was continued to maintain the hyperlipidemia state. The blood was collected and the related indexes of hemorheology and the components of erythrocyte membrane were determined. Results:Compared with the model group, the plasma contents of triglyceride (TG), totel cholesterol (TC), low-density lipoprotein cholesterol (LDL-C) and glucose (GLU) were significantly decreased in three prescription groups (P<0.05, P<0.01), and the content of high-density lipoprotein cholesterol (HDL-C) was significantly increased (P<0.05, P<0.01). Three prescriptions could decrease the whole blood viscosity and plasma viscosity (P<0.05,P<0.01), and the activated partial thromboplastin time (APTT) could be extended and the content of fibrinogen (FIB) could be decreased (P<0.05, P<0.01). Danshen Drink and Buyang Huanwu Decoction could also significantly prolong the prothrombin time (PT) (P<0.05). The contents of sulfydryl and SOD were significantly increased after the treatment of three prescriptions (P<0.05, P<0.01). In addition, Danshen Drink increased Na+-K+-ATPase activity and decreased the content of malondialdehyde (MDA) (P<0.05, P<0.01). Buyang Huanwu Decoction obviously increased Na+-K+-ATPase activity and the content of sialic acid (P<0.05, P<0.01). Shaofu Zhuyu Decoction significantly increased the content of sialic acid (P<0.01). Conclusion:All three prescriptions show the effects of activating blood and removing blood stasis and hypolipidemic activity. Their common points may be improving the free radical elimination and antioxidant capacity. In addition, three prescriptions also improve the blood stasis state by improving the deformability and aggregation of erythrocytes, so as to activate blood, remove blood stasis and reduce blood lipid.关键词：Buyang Huanwu Decoction;Shaofu Zhuyu Decoction;Danshen Drink;hyperlipidemia;rat;erythrocyte membrane
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发布时间：2022-08-31 - 摘要：Objective:To investigate the protective effects of Shihu Yeguang Pill against light-induced photoreceptor degenerative changes. MethodsBALB/c mice were randomly divided into the normal control group, model group and Shihu Yeguang Pill treatment groups at different time points. The retinal light damage model was established in the model group and Shihu Yeguang Pill treatment groups by incandescent light at intensity of (10 000±10)lx lux for 30 min. The Shihu Yeguang Pill treatment groups were treated for continuous 7 days, and 24 hours before illumination the mice were received dark adaptation. The treatment groups were treated with decoction of Shihu Yeguang Pill by intragastric administration at volume of 200 μl immediately or 30 minutes before illumination. The normal control group and model group were treated with 0.9% NaCl solution at equivalent volume. 7 days after illumination, the optical coherence tomography (OCT) imaging was performed to detect the retinal structure of mice. The paraffin sections were made to perform the hematoxylin and eosin (HE) staining and immunohistochemical assessment of rhodopsin (RHO) and mid-wavelength sensitive cone opsin (M-opsin), in order to further clarify the changes of retinal morphology and patho logical changes of rod cells and cone cells. Results:The retinal structures in the normal control group were intact, and the expressions and disposition of RHO and M-opsin were normal. Compared with the normal control group, the outer nuclear layer was obviously thinner in the model group, the structures of outer and inner segment layers of photoreceptor were disorganized and the expressions of RHO and M-opsin were remarkably decreased. Compared with the model group, the retinal structures were nearly intact and clear in Shihu Yeguang Pill treatment groups, and the expressions of RHO and M-opsin were increased. Conclusion:Shihu Yeguang Pill shows significant protective effects against light-induced photoreceptor degenerative changes.关键词：Shihu Yeguang Pill;retinal degenerative changes;mouse;light damage;photoreceptor protection
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发布时间：2022-08-31 - 摘要：Objective:To establish the quality control method for Dongbo Tonglin Granule, which includes Huangbo (Phellodendri Chinensis Cortex), Rendongteng (Lonicerae Japonicae Caulis) and Bianxu (Polygoni Avicularis Herba). MethodsThe identifications of Huangbo, Rendongteng and Bianxu in this compound prescription were conducted by thin layer chromatography (TLC). The contents of berberine and chlorogenic acid were determined by high performance liquid chromatography (HPLC). Results:The identification and separation of TLC was good and highly specific, and no interference was observed in the negative sample. The berberine showed a good linearity in the range of 0.108~2.16 μg (r=0.999 5). The average recovery was 101.61%(RSD=2.53%). The chlorogenic acid showed a good linearity in the range of 0.114~2.28 μg (r=0.999 6). The average recovery was 99.91%(RSD=2.32%). Conclusion:This method is simple, accurate and reliable with strong specificity, and can be used for the quality control of Dongbo Tonglin Granule.关键词：Dongbo Tonglin Granule;thin layer chromatography;high performance liquid chromatography;berberine;chlorogenic acid
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发布时间：2022-08-31 - 摘要：This paper reviews the research progress of intervention of Chinese medicine on protein and gene expressions of uric acid transporters. The uric acid transporters play an important role in the transport of uric acid. Researches have showed that some single herbs, effective components in single herbs and compound recipes can decrease the blood uric acid level in hyperuricemia animal model through interfering the expressions of uric acid transporters. Molecular biology technology and gene technology can be used to elucidate the targets and mechanisms of Chinese medicine in lowering uric acid.关键词：hyperuricemia;uric acid transporter protein;protein/gene expression;therapy of traditional Chinese medicine;review
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发布时间：2022-08-31 - 摘要：This paper reviews the research progress of Chinese medicine on inhibiting proliferation and inducing apoptosis of hepatoma carcinoma cells based on signaling transduction pathways. Chinese medicines and their extracts can change the peculiarity of hepatoma carcinoma cells and exert the proliferation inhibition and apoptosis induction effects through regulating hepatoma carcinoma-related signaling pathways such as MAPK signal transduction pathway, PI3K/AKT signal transduction pathway, JAK-STAT signaling pathway, Caspase pathway, Wnt signaling pathway and so on.关键词：Chinese medicine;hepatoma carcinoma;proliferation;apoptosis;signal transduction pathway;review
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发布时间：2022-08-31
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