最新刊期
期 7 ， 2018
- 摘要：This paper discusses Xie Jingri’s experience in the treatment of ascites due to cirrhosis based on classical prescriptions. It is believed that the characteristics of this disease are deficiency in origin and excess in superficiality,struggle between vital qi and pathogenic factors. The deficiency in origin includes deficiency of yin,yang,qi and blood in liver,spleen and kidney,and the excess in superficiality includes intermingled struggle among qi,blood,water and toxin. In the clinical diagnosis and treatment,the classic prescriptions are made good use,such as Wuling Powder,Wupi Decoction,Bazheng Powder,Gexia Zhuyu Decoction,Sini Powder,Gancao Xiexin Decoction,Liuwei Dihuang Pill,Sijunzi Decoction,with modified Sanhuang Decoction retention enema.关键词：ascites due to cirrhosis;classical prescriptions;experience of famous doctor;Xie Jingri
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发布时间：2022-08-31 - 摘要：This paper discusses the development of Shanghan Lun(Treatise on Cold Pathogenic Diseases) from classical paradigm into common methods that can deal with the whole fever diseases. The basic clinical problems that involved in Shanghan Lun,such as identification and diagnosis,syndrome differentiation rules,compatibility and incompatibility of treatment methods,treatment for accompanied symptoms and regulation after recovery,form a certain pattern and system and can be considered as the classic paradigm. In the long clinical practice,Yu Genchu in Qing Dynasty writes Tongsu Shanghan Lun,which develops Shanghan Lun from classic into common based on the view of clinical therapy. In this book,the structure is unchanged but the outline is clearer,the concepts are constant but the views are more profound,the disease syndromes are unchanged but the contents are obviously expanded,the treatment methods are the same but the prescriptions are innovative. This is Yu Genchu's best interpretation for classical Shanghan Lun from clinical view.关键词：Shanghan Lun(Treatise on Cold Pathogenic Diseases);classical paradigm;Tongsu Shanghan Lun;change according to custom
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发布时间：2022-08-31 - 摘要：Emotional factors can lead to menstrual disorders. Liver is considered as the innate basis of women,dysfunction of Chong and Ren meridian caused by excess of seven emotions is the physiological and pathological basis. The basic pathogenesis of menstrual disorders due to depression syndrome includes stagnation of liver qi transforming into fire,deficiency of both heart and spleen,blood stasis and phlegm stagnation,deficiency of qi and blood,liver and kidney. In the treatment,it needs the therapy with syndrome differentiation that taking into account of the specificity of uterine bleeding and amenorrhea,and it can not ignore the importance of emotional therapy. Menstrual disorders due to depression syndrome are mainly found in the functional diseases caused by mental and psychological factors in modern medicine,such as dysfunctional uterine bleeding,stress amenorrhea,and other mental disorders such as depression and anxiety.关键词：depression syndrome;menstrual disorders;physiology and pathology;pathogenesis and syndrome-treatment
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发布时间：2022-08-31 - 摘要：Objective:To systematically evaluate the clinical efficacy of Baitouweng Decoction combined with mesalazine in the treatment of ulcerative colitis. MethodsDatabases were searched from database creation to December 2017 to collect the randomized controlled trials(RCT) reports about Baitouweng Decoction combined with mesalazine in treating ulcerative colitis which compared with mesalazine. The literature screening,data extraction and quality evaluation were conducted independently by two researchers. The Meta-analysis was conducted by RevMan 5.3 and Stata software. Results:A total of 12 RCT literatures involving 842 patients were included. The results of Meta-analysis showed that Baitouweng Decoction combined with mesalazine showed better comprehensive efficacy and endoscopic mucosal efficacy compared with mesalazine. It also showed better improvement on symptoms such as abdominal pain and bloody purulent stool. However,no statistically significant difference on improvement of diarrhea was observed(P>0.05). Conclusion: Compared with mesalazine alone,Baitouweng Decoction combined with mesalazine shows better comprehensive efficacy and endoscopic mucosal efficacy in the treatment of ulcerative colitis,and the improvement effects on abdominal pain and bloody purulent stool are also better than mesalazine alone. However,due to the low quality of the included literatures,the above conclusion needs further verification by high quality studies.关键词：Baitouweng Decoction;mesalazine;ulcerative colitis;Meta-analysis
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发布时间：2022-08-31 - 摘要：This paper introduces Professor Xia Xiang’s experience in treating miscellaneous diseases of internal and surgical medicine with Centella asiatica. It shows the efficacy of clearing heat and promoting diuresis and removing toxicity for detumescence. External application can be used to repair skin scars,and oral administration can be used for acne,urticaria,erysipelas and other skin diseases,oral ulcers,chronic nephritis and other autoimmune diseases,joint swelling and pain,degeneration and other bone and joint diseases. The application characteristics of the commonly used couplet medicines are also analyzed. Two proven cases are presented.关键词：Centella asiatica;experience of famous dotcor;Xia Xiang
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发布时间：2022-08-31 - 摘要：This paper summarizes Professor Zhan Hongsheng’s experience in the treatment of cervical spondylosis. It is considered that the primary pathogenesis of cervical spondylosis is“Jin Chu Cao and Gu Cuo Feng”,and the evaluation index system for clinical diagnosis and treatment is established. For treatment,it advocates harmonizing qi and blood with Chinese medicine and acupuncture,manipulation and Daoyin to adjust muscle and joint,which could restore the balanced state between muscle and joint as well as qi and blood.
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发布时间：2022-08-31 - 摘要：This paper discusses WU Huanlin’s experience in the treatment of hypertension in Lingnan area based on removing phlegm. The climate of Lingnan area is damp and hot,and the patients are suffered from phlegm and dampness. It is considered that the main pathogenesis is intermingled phlegm and blood stasis due to spleen deficiency and wind-phlegm invading upward,and the therapy of removing phlegm is emphasized. Two proven cases are presented.关键词：hypertension;therapy of removing phlegm;Lingnan;experience of physician;Wu Huanlin
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发布时间：2022-08-31 - 关键词：abdominal scar endometriosis;Xiaozheng Zhitong Recipe;proven case
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发布时间：2022-08-31 - 摘要：This paper introduces the application indications of Guizhi Decoction and its associated prescriptions in the spleen and stomach diseases. It is considered that it can tonify middle-jiao,and the clinical practice should grasp the way of diagnosis and treatment of “human-symptom-recipe-drug”,the selection and modification of classical prescriptions should be used for definite indications. Two typical medical cases are presented.关键词：gastric ulcer;diarrhea-predominant irritable bowel syndrome;spleen and stomach diseases;Guizhi Decoction;Guizhi Decoction associated prescriptions;prescription and syndrome
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发布时间：2022-08-31 - 摘要：This paper summarizes the theory of pulse-taking in Jingyue Quanshu(Jingyue's Complete Works). The characteristics are summed up as follows:The pulse theory is explained and the concurrent pulse is discussed in detail. The pulses are divided into yin and yang,and the pulses are well classified. The comprehensive analysis of data gained by four diagnostic methods should be performed,and the palpation is as the last in the four diagnostic methods. The stomach qi should be paid attention,and the anomalies are judged from normal. The Du theory is explained detailedly,and the true and false syndromes are distinguished.关键词：Zhang Jiebin;Jingyue Quanshu(Jingyue's Complete Works);pulse-taking;stomach qi;four diagnostic methods
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发布时间：2022-08-31 - 摘要：This paper summarizes Lu Bosi’s four treatments on acute infantile convulsion,including suppressing hyperactive liver,clearing away heart-fire,strengthening spleen and nourishing kidney. The symptomatic treatment in acute condition should be performed,the treatment of suppressing hyperactive liver focuses on liver,which could block wind and alleviate convulsion. The treatment of clearing away heart-fire for tranquilization focuses on heart,which could relieve convulsion. The treatment of strengthening spleen focuses on spleen,which could dispel phlegm and remove sialorrhea,eliminate pathogenic factors and ease convulsion. The treatment of nourishing kidney focuses on kidney,which could invigorate yin,consolidate body resistance and stop convulsion.
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发布时间：2022-08-31 - 摘要：Objective:To observe the clinical efficacy of Qici Sanling Decoction combined with Pirarubicin in the treatment of non-muscle invasive bladder cancer. Methods100 TUR-BT postoperative patients with non-muscle invasive bladder cancer were randomly divided into the treatment group(66 cases) and control group(34 cases). The control group was treated with Pirarubicin by intravesical instillation and the treatment group was orally treated with Qici Sanling Decoction based on the treatment for the control group,with a course of 1 year,and the patients were followed-up for 1 year after treatment. The tumor recurrence and medication safety were observed. The changes on correlative symptoms,life quality scale(QLQ-C30 and QLQ-BLS24 sub-scales),immune function indexes such as NK cells,CD4+ and CD8+ were compared. Results:①Within 1 year after treatment,the recurrence rates were 15.6% in the treatment group and 25.0% in the control group,the recurrence rate in the treatment group was obviously lower than that in the control group(P<0.05). ②After treatment,there were statistically significant differences on the scores of fatigue,pain,insomnia,constipation,physical function,emotional function and overall health condition between the two groups,and the improvement in the treatment group was obviously better than that in the control group(P<0.05). ③After treatment,there were statistically significant differences on the scores of urination symptoms,intestinal symptoms,treatment relative problems and sexual life quality between the two groups,and the improvement in the treatment group was obviously better than that in the control group(P<0.05). ④After treatment,there were statistically significant differences on the levels of NK cells,CD4+ and CD8+ between the two groups,and the improvement in the treatment group was obviously better than that in the control group(P<0.05). ⑤There was no statistically significant difference on the incidence rate of adverse reactions between the two groups(P>0.05). Conclusion:Qici Sanling Decoction combined with Pirarubicin in treating postoperative patients with non-muscle invasive bladder cancer can significantly reduce the cancer recurrence rate,enhance the systemic immunity,alleviate the side effects caused by chemotherapy drug instillation and improve the overall quality of life.关键词：non-muscle invasive bladder cancer;Qici Sanling Decoction;recurrence after operation;reducing toxicity and enhancing efficacy;quality of life;traditional Chinese medicine
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发布时间：2022-08-31 - 摘要：Objective:To observe the efficacy of Jianpi Moji Jiedu Decoction combined with routine western medicine in the treatment of hepatitis C cirrhosis in compensatory stage. Methods66 patients with hepatitis C cirrhosis in compensatory stage were randomly divided into the control group and treatment group,33 cases in each group. The control group was treated with routine western medicine,and the treatment group was treated with Jianpi Moji Jiedu Decoction based on the treatment for the control group,with a course of 48 weeks. The changes on liver function indexes,Child-Pugh score,virological response,serum liver fibrosis indexes,liver stiffness measurement value and score of liver B-mode ultrasound were compared. Results:①The response rate in the early stage and at the end of the treatment and the sustained response rate in the treatment group were higher than those in the control group,with statistically significant differences(P<0.05). ②Compared with treatment before,the levels of alanine aminotransferase(ALT),aspartate aminotransferase(AST),total bilirubin(TBIL) and Child-Pugh score were decreased(P<0.05) while the albumin(ALB) level was increased(P<0.05) in the treatment group after treatment. Only the ALT and AST levels were decreased in the control group after treatment(P<0.05). After treatment,there were statistically significant differences on the liver function indexes and Child-Pugh score between the two groups(P<0.05). ③Compared with treatment before,the levels of hyaluronic acid(HA),laminin(LN),procollagen type III(PCIII) and collagen type IV(Ⅳ-C),the liver stiffness measurement value,the liver score and the B-mode ultrasound score were decreased in both groups after treatment(P<0.05). After treatment,there were statistically significant differences on serum liver fibrosis indexes,liver stiffness measurement value,liver score and B-mode ultrasound score between the two groups(P<0.05). Conclusion:Jianpi Moji Jiedu Decoction combined with routine western medicine in the treatment of hepatitis C cirrhosis in compensatory stage can effectively improve the antiviral efficacy,ameliorate the liver function of patients and inhibit the hepatic fibrosis process.关键词：hepatitis C cirrhosis in compensatory stage;Jianpi Moji Jiedu Decoction;liver fibrosis;virological response rate;liver score
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发布时间：2022-08-31 - 摘要：Objective:To observe the clinical efficacy of “Shenqi No.1 Prescription” combined with routine treatment of western medicine in the treatment of early diabetic kidney disease(DKD). Methods89 patients with early DKD patients were randomly divided into the treatment group(45 cases) and control group(44 cases). The control group was treated with the routine treatment of western medicine,the treatment group was treated with “Shenqi No.1 Prescription” based on the treatment for the control group,with a course of 6 months. The changes on the indexes such as fasting plasma glucose(FPG),2 h postprandial glucose(2hPG),glycosylated hemoglobin(HbA1c),homeostasis model assessment of insulin resistance(Homa-IR),urinary microalbumin(mALB),serum creatinine(Scr) and glomerular filtration rate(eGFR) were observed. Results:①Compared with treatment before,there were statistically significant differences on the levels of 2hPG,HbA1c and Homa-IR in the treatment group after treatment(P<0.05),but no statistically significant differences on all the glycemic indexes in the control group were observed after treatment(P>0.05). After treatment, there was statistically significant difference on Homa-IR level between the two groups(P<0.05). ②Compared with treatment before,there was statistically significant difference on the mALB level in the treatment group after treatment(P<0.05). After treatment,the mALB level in the treatment group was obviously lower than that in the control group(P<0.05). Conclusion:“Shenqi No.1 Prescription” combined with routine treatment of western medicine in the treatment of early diabetic kidney disease can improve the insulin resistance, stabilize the blood glucose,protect the renal function, and thus delay the disease progression and ameliorate the prognosis of patients.关键词：diabetes;chronic kidney disease;“Shenqi No.1 Prescription”;blood glucose;renal function
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发布时间：2022-08-31 - 摘要：Objective:To observe the effects of Danshen Injection combined with mesalazine on the serum levels of hypoxia inducible factor -1α(HIF-1α) and inflammatory cytokines such as tumor necrosis factor-α(TNF-α),interleukin-6(IL-6) and IL-10 in patients with mild to moderate active ulcerative colitis(UC). Methods78 patients with mild to moderate active UC were randomly divided into the control group and treatment group,39 cases in each group. The control group was treated with mesalazine,and the treatment group was treated with Danshen Injection based on the treatment for the control group,with a course of 2 weeks. The clinical efficacy was observed. The changes on clinical symptom scores,serum levels of HIF-1α,cyclooxygenase-2(COX-2)and inflammatory cytokines,Sutherland disease activity index(DAI) score and endoscopic mucosal score were compared. Results:①The total effective rates were 92.31% in the treatment group and 74.36% in the control group,and the clinical efficacy of the treatment group was better than that of the control group(P<0.05). ②After treatment,the scores of diarrhea,pus and blood stool,abdominal pain and abdominal distension in the treatment group were lower than those in the control group(P<0.01). ③After treatment,the DAI score and endoscopic mucosal score in the treatment group were lower than those in the control group(P<0.05). ④After treatment,the serum levels of HIF-1α,COX-2,TNF-α and IL-6 in the treatment group were lower than those in the control group(P<0.05),and the IL-10 level in the treatment group was higher than that in the control group(P<0.05). Conclusion:Danshen Injection combined with mesalazine shows satisfactory efficacy in treatment of mild to moderate active ulcerative colitis,compared with mesalazine alone,it can better relieve the clinical symptoms of patients,promote the intestinal mucosal repair and enhance the clinical efficacy. Its mechanism may be associated with down-regulating HIF-1α expression and up-regulating IL-10 expression.关键词：ulcerative colitis;Danshen Injection;mesalazine;HIF-1α;IL-10
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发布时间：2022-08-31 - 摘要：Objective:To observe the clinical efficacy of Shugan Dingji Decoction combined with propafenone in the treatment of proiosystole with syndrome of stagnant liver qi. Methods 60 patients of proiosystole with syndrome of stagnant liver qi were randomly divided into the treatment group and control group,30 cases in each group. The control group was treated with propafenone,and the treatment group was treated with Shugan Dingji Decoction based on the treatment for the control group,with a course of one month. The clinical efficacy and safety were observed. The changes on frequency of premature beats in 24 h dynamic electrocardiogram and traditional Chinese medical(TCM) syndrome scores were compared. Results:①The total effective rates were 65.5% in the treatment group and 37.9% in the control group,and there was statistically significant difference on the clinical efficacy between the two groups(P<0.05). ②After treatment,there was statistically significant difference on the frequency of premature beats in 24 h dynamic electrocardiogram between the two groups,and the frequency in the treatment group was obviously lower than that in the control group(P<0.05). ③After treatment,there were statistically significant differences on the scores of palpitation,chest pain,depression and irritability,restless sleep,deep sigh and the total score between the two groups,and the improvements on TCM syndrome scores in the treatment group were better than those in the control group(P<0.05). ④Before and after treatment,no abnormality on blood routine examination and liver and kidney function examination was observed in both groups. Conclusion:Shugan Dingji Decoction combined with propafenone in the treatment of proiosystole with syndrome of stagnant liver qi shows better efficacy than propafenone alone,which can obviously improve the clinical symptoms such as premature beat in patients.关键词：palpitation;premature beats;diagnosis and treatment based on liver;therapy of dispersing stagnated liver qi for relieving palpitation;Chaihu Longgu Muli Decoction
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发布时间：2022-08-31 - 摘要：Objective:To observe the clinical efficacy of Yimu Gushen Decoction combined with active immunotherapy in the treatment of unexplained recurrent abortion. Methods56 patients with unexplained recurrent abortion were randomly divided into the treatment group and control group,28 cases in each group. The control group was treated with active immunotherapy,and the treatment group was treated with Yimu Gushen Decoction based on the treatment for the control group. The clinical efficacy,pregnancy outcome and medication safety were observed. The changes on the levels of immune indexes such as immunoglobulin G(IgG),immunoglobulin A(IgA),immunoglobulin M(IgM),complement C3(C3),complement C4(C4) and T lymphocyte subsets CD4+ and CD8+,and the levels of sex hormones such as progesterone and human chorionic gonadotropin(HCG) were compared. Results:①The total effective rates were 89.3% in the treatment group and 64.3% in the control group,the clinical efficacy in the treatment group was obviously better than that in the control group(P<0.05). ②After treatment,there were statistically significant differences on the levels of IgG,IgA,IgM and C3 between the two groups,and the levels were obviously reduced in the treatment group compared with those in the control group(P<0.05). After treatment,the CD8+ level in the treatment group was obviously higher than that in the control group,while the levels of CD4+ and CD4+/CD8+ were obviously lower than those in the control group(P<0.05). ③After treatment,there were statistically significant differences on the levels of HCG and progesterone between the two groups,and the levels were obviously increased in the treatment group compared with those in the control group(P<0.05). ④The abortion rate in the treatment group was obviously lower than that in the control group(P<0.05). ⑤No adverse reaction related to the intervention in this study was observed during the trial. Conclusion:The active immunotherapy combined with Yimu Gushen Decoction in the treatment of unexplained recurrent abortion can improve the immune imbalance and sex hormone levels,reduce the risk of miscarriage as well as improve the pregnancy outcome,which is more safe.关键词：recurrent abortion;habitual abortion;Yimu Gushen Decoction;active immunity;abnormality of immune tolerance
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发布时间：2022-08-31 - 摘要：This paper introduces the experience in clinical application of Gouteng Powder.It is considered that the indications of Gouteng Powder are complicated syndromes as wind-fire-phlegm invading upward combined with deficiency of qi and yin,which is characterized by coexistence of wind,fire,phlegm and deficiency.For liver-syncope,patients are suffered from deadly cold hands and feet due to liver-fire uprush,and the spirits are easily to be injured,which is closely related to emotion.3 proven cases are presented.关键词：Gouteng Powder;liver-syncope;treating different diseases with same method
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发布时间：2022-08-31 - 摘要：Objective:To investigate the cardioprotective effects of Rougui(Cinnamomi Cortex) on diabetic cardiomyopathy in rats. MethodsThe diabetes model in SD rats was established by single intraperitoneal injection of streptozotocin(STZ) at a dose of 85 mg/kg,which then induced myocardial injury. The normal rats were taken as the normal group. The model animals were randomly divided into the model group,captopril group(50 mg/kg) and Rougui group(0.75 g/kg),and were treated with corresponding drugs by intragastric administration. After treatment for 26 days,the animals were anesthetized and the electrocardiogram(ECG) of rats was measured by multichannel physiological signal acquisition and processing system. The left ventricle was separated and weighed,and the left ventricular weight index(LVWI) was calculated. The serum levels of blood glucose(GLU),total cholesterol(TC),triglyceride(TG),high density lipoprotein(HDL) and low density lipoprotein(LDL) were detected by automatic biochemical analyzer. The serum level of brain natriuretic peptide(BNP) was detected by ELISA. The activities of Na+K+-ATP and Ca2+Mg2+-ATP enzymes in myocardial tissue were detected by phosphorus quantitation. The contents of phosphocreatin(PCr),adenosine triphosphate(ATP),adenosine monophosphate(ADP) and adenosine monophosphate(AMP) in myocardium were tested by high performance liquid chromatography(HPLC). Results:Compared with the normal group,the LVWI and the serum levels of GLU,TC,TG,LDL and BNP were significantly increased,and the intervals of QRS,P-R,S-T and Q-T were prolonged in the model group. In addition,the heart rate was slowed down,and the activities of Na+K+-ATP and Ca2+Mg2+-ATP enzymes in myocardial tissue and the contents of PCr,ATP,ADP and AMP were significantly decreased. Compared with the model group,the serum levels of TG,TC,LDL and BNP were significantly decreased,the intervals of QRS and P-R were significantly shortened,the Ca2+Mg2+-ATP enzyme activity and the contents of PCr,ATP and ADP in myocardial tissue were increased significantly in the Rougui group. Conclusion:Rougui(Cinnamomi Cortex) may improve the myocardial injury in diabetic rats through the effects on energy metabolism of myocardium.关键词：Rougui(Cinnamomi Cortex);diabetes;cardiomyopathy;energy metabolism
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发布时间：2022-08-31 - 摘要：Objective:To observe the protective effects of curcumin on lipopolysaccharide(LPS) induced inflammatory injury in H9c2 cardiac myocytes,and preliminarily explore the potential mechanism. MethodsThe H9c2 cardiac myocytes were divided into the control group,LPS group and curcumin treatment groups. Except the control group,the LPS induced inflammatory injury model in cardiac myocytes was established in the other groups. The cells in the curcumin treatment groups were treated with curcumin at concentrations of 10 μmol/L,20 μmol/L and 40 μmol/L,respectively. After cultured for 24 hours,the survival rate of H9c2 cells was measured by CCK8 kit,the levels of inflammatory cytokines such as IL-6 and TNF-α were detected by ELISA,and the protein expression levels of PI3K,Akt and p-Akt were detected by Western blot. After pre-treatment with 5 μmol/L PI3K inhibitor(LY294002) for 4 hours,the LPS was added into the cells to induce the injury,then the cells were treated with 20 μmol/L curcumin. The survival rate of cells,the levels of inflammatory cytokines and the expression levels of PI3K/Akt pathway related proteins were detected in each group,including the control group,LPS group,LPS+ LY294002 group,LPS+ curcumin group and LY294002+LPS+ curcumin group. Results:Compared with the control group,the relative survive rate of H9c2 cells was significantly decreased in the LPS group(P<0.05),the IL-6 and TNF-α levels in the cell supernatant were increased significantly(P<0.05),and the protein expressions of PI3K and p-Akt were significantly decreased(P<0.05). Compared with the LPS group,after treatment with curcumin at different concentrations,the relative survive rate of H9c2 cells was significantly increased(P<0.05),the IL-6 and TNF-α levels were significantly decreased(P<0.05),and the protein expressions of PI3K and p-Akt were significantly increased(P<0.05). Compared with the LPS+ curcumin group,after treatment with LY294002,the protective effects of curcumin on LPS induced inflammatory injury in H9c2 cardiac myocytes were significantly reduced,the cell survival rate was obviously decreased in LY294002+LPS+ curcumin group(P<0.05),the levels of IL-6 and TNF-α were significantly increased(P<0.05),and the protein expressions of PI3K and p-Akt were significantly decreased(P<0.05). Conclusion:Curcumin exerts protective effects on LPS induced inflammatory injury in H9c2 cardiac myocytes,and its mechanism may be associated with activating PI3K/Akt signaling pathway.关键词：curcumin;H9c2 cardiac myocytes;inflammation;PI3K/Akt
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发布时间：2022-08-31 - 摘要：Objective:To observe the improvement effects of Shengmai Decoction on the insulin resistance in type 2 diabetes mellitus(T2DM) rats,and discuss its possible mechanisms. MethodsThe T2DM rat model with insulin resistance was established by intraperitoneal injection of low-dose streptozotocin combined with high sugar and fat diet. The rats were divided into the normal group,model group,metformin group and Shengmai Decoction groups with low-,middle- and high-dose,10 rats in each group. The metformin group was treated with 4.0 mg·kg-1 of metformin,the Shengmai Decoction groups with low-,middle- and high-dose were treated with Shengmai Decoction at doses of 50,0 and 400 mg·kg-1,respectively,the control group and the model group were treated with 0.9% NaCl solution at equivalent volume. After treatment for continuous 6 weeks,the serum levels of fasting blood glucose(FBG) and fasting insulin(FINS) were measured by kits and the insulin sensitivity index(ISI) was calculated. The serum levels of interleukin-6(IL-6) and tumor necrosis factor α(TNF-α) were detected by ELISA. The protein expressions of insulin receptor substrate -1(IRS-1),phosphatidylinositol -3- hydroxykinase p85 subunit(PI3Kp85) and glucose transporter(GLUT4) in skeletal muscle tissues were detected by Western blot. The Glut4 mRNA expression in skeletal muscle tissue was detected by RT-PCR. Results:After treatment with Shengmai Decoction at different doses,the serum levels of FBG,FINS,TNF-α and IL-6 in diabetic rats were obviously decreased(P<0.05),the protein expressions of IRS-1 and PI3Kp85 were increased,and the protein and mRNA expressions of GLUT4 were up-regulated significantly in skeletal muscle tissues(P<0.05),in a dose-dependent manner. There were no statistically significant differences on the levels of TNF-α,IL-6,PI3Kp85 and GLUT4 between the metformin group and Shengmai Decoction group with high-dose. Conclusion:Shengmai Decoction can significantly improve the insulin resistance in diabetic rats. Its mechanism may be associated with alleviating inflammatory responses and up-regulating the protein expressions of IRS-1,PI3Kp85 and GLUT4.
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发布时间：2022-08-31 - 摘要：Objective:To explore the effects of (-)-Gallocatechin on the glucose uptake when the adipocytes were treated with high concentration of glucose. MethodsThe effects of (-)-Gallocatechin on glucose uptake and differentiation of 3T3-L1 preadipocytes were detected using a 3T3-L1 preadipocytes differentiation model. Results:The (-)-Gallocatechin increased insulin-stimulated glucose uptake in adipocytes under the condition of high-concentration glucose(30 mmol/L) and accelerated the differentiation of 3T3-L1 preadipocyte. Conclusion:The (-)-Gallocatechin increases the glucose uptake in adipocytes and promotes the differentiation of 3T3-L1 preadipocytes,which suggests that (-)-Gallocatechin may effectively improve the glycemic control and ameliorate the insulin resistance.关键词：(-)-Gallocatechin;glucose uptake;differentiation of 3T3-L1 preadipocytes
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发布时间：2022-08-31 - 摘要：Objective:To observe the effects of Cangju Qinggan Jiangzhi Formula on SIRT3-FOXO3 signaling pathway in mice with nonalcoholic steatohepatitis induced by methionine-choline deficient(MCD) diet. MethodsSixty C57BL/6 mice(male and female in half) were randomly divided into the control group,model group,Cangju Qinggan Jiangzhi Formula groups with high-,middle- and low-dose and Essentiale group. The control group was given methionine-choline sufficient(MCS) diet,while the other groups were given MCD diet,all of the mice were free to eat. Meanwhile,each group was treated with the corresponding drugs by intragastric administration,and the control group and the model group were treated with drinking water. After modeling,the serum levels of tumor necrosis factor-α(TNF-α) and interleukin-6(IL-6) and the levels of superoxide dismutase(SOD) and malondialdehyde(MDA) in liver tissue were detected. The total RNA and total protein in mice liver were extracted. The mRNA and protein expression levels of SIRT3 and FOXO3 were detected by Real-time PCR and Western blot. Results:Compared with the control group,the serum levels of TNF-α and IL-6 were significantly increased,the SOD activity in liver tissue was decreased and the content of MDA was increased in the model group,with statistically significant differences(P<0.05). Compared with the model group,the levels of TNF-α,IL-6 and MDA were decreased and the SOD activity was increased in the Cangju Qinggan Jiangzhi Formula groups with different doses,which showed the tendency in a dose-dependent manner. The effect of Cangju Qinggan Jiangzhi Formula group with high-dose was similar to that of the Essentiale group. The mRNA and protein levels of SIRT3 and FOXO3 were highly expressed in the control group while significantly down-regulated in the model group. After the treatment with Cangju Qinggan Jiangzhi Formula groups with high-,middle- and low-dose and Essentiale,the expressions of SIRT3 and FOXO3 were up-regulated. Conclusion:Cangju Qinggan Jiangzhi Formula can improve the liver injury due to MCD diet induced nonalcoholic steatohepatitis through regulating SIRT3-FOXO3 signaling pathway.关键词：methionine-choline deficient diet;nonalcoholic stepatohepatitis;Cangju Qinggan Jiangzhi Formula;SIRT3-FOXO3 signaling pathway
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发布时间：2022-08-31 - 摘要：Objective:To observe the regulation effects of Changqi Drink on the levels or gene expressions of some brain-gut peptides in diarrhea-predominant irritable bowel syndrome(IBS-D) rats with syndrome of liver stagnation and spleen deficiency. Methods72 SPF male Wistar rats were randomly divided into the normal group,model group,Dicetel group and Changqi Drink group,18 rats in each group. Except the normal group,the IBS-D model with syndrome of liver stagnation and spleen deficiency was established by chronic restraint stress and folium sennae decoction in the other groups. Each group was treated with 0.9%NaCl solution,Dicetel and Changqi Drink decoction respectively. The serum level of 5-hoxytryptamine(5-HT) and the mRNA expressions of substance P(SP) and vasoactive intestinal peptide(VIP) in hypothalamus and colon tissue were detected. Results:Changqi Drink could decrease the serum level of 5-HT and down-regulate the mRNA expressions of SP and VIP in hypothalamus and colon tissue(P<0.05). Conclusion:Changqi Drink can regulate the dysfunction of brain-intestinal axis of IBS-D rats with syndrome of liver stagnation and spleen deficiency by decreasing the serum level of 5-HT and down-regulating the mRNA expressions of SP and VIP in hypothalamus and colon tissue.关键词：Changqi Drink;irritable bowel syndrome;brain-gut peptide;5-hoxytryptamine;vasoactive intestinal peptide;substance P
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发布时间：2022-08-31 - 摘要：Objective:To explore the mechanism of Modified Niduqing Mixture on the renal interstitial fibrosis in rats with unilateral ureteral obstruction(UUO). Methods50 male SD rats were selected. Except 10 rats in the sham-operation group,the UUO model was established in the other rats. After modeling,the rats were randomly divided into the model group,Erbesartan group,Chinese medicine groups with low-dose and high-dose,10 rats in each group. The rats were treated with the corresponding drugs. The urinary levels of N-acetyl β-D-Glucosaminidase(NAG enzyme) and β2-microglobulin(β2-MG),the serum creatinine(Scr),blood urea nitrogen(BUN),and the expressions of transforming growth factor-β1(TGF-β1) and α-smooth muscle actin(α-SMA) in renal tissue were detected,and the renal pathology were observed. Results:①There was no significant difference on the urinary β2-MG level among these groups(P>0.05). ②Compared with the sham-operation group,the urinary level of NAG on the 14th day and 28th day was increased significantly in the model group,Chinese medicine groups with low- and high-dose,with statistically significant differences(P<0.05). The NAG level on the 28th day in the high-dose group was decreased significantly compare with the model group(P<0.05). ③The Scr level on the 15th day in the Chinese medicine group with high-dose was decreased significantly compared with the model group and Erbesartan group,with statistically significant differences(P<0.05). The Scr level on the 29th day in the Chinese medicine group with high-dose was significantly decreased compared with the model group,with statistically significant difference(P<0.05). ④Compared with the Erbesartan group,the BUN level was decreased in the Chinese medicine group with high-dose,with statistically significant difference(P<0.05). There was no statistically significant difference on the BUN level among these groups on the 29th day(P>0.05). ⑤Compared with the sham operation group,there were statistically significant differences on the expression levels of α-SMA and TGF-β1 in the model group,Erbesartan group and Chinese medicine groups with low- and high-dose(P<0.05). Compared with the model group,there were also statistically significant differences on the expression levels of α-SMA and TGF-β1 in the Erbesartan group,Chinese medicine groups with low- and high-dose(P<0.05). Conclusion:Modified Niduqing Mixture can reduce the urinary NAG enzyme and inhibit the expressions of α-SMA and TGF-β1 in the renal tissue,thus alleviate the renal interstitial fibrosis.关键词：Modified Niduqing Mixture;unilateral ureteral ligation;renal interstitial fibrosis;rats
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发布时间：2022-08-31 - 摘要：This paper reviews the dosage forms and improved methods of curcumin carrier based on its solubility,bioavailability and disease improvement. There are various forms of curcumin sustained-release carrier,such as solid dispersion carrier,liposome carrier,nanoparticle carrier,nanomicelle carrier,self-microemulsion carrier,microsphere and microcapsule carrier and hydrogel carrier. Through the experiments in vitro and in vivo,most of them can effectively improve solubility,bioavailability and behavior.关键词：curcumin;sustained-release carrier;dosage form;review
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发布时间：2022-08-31 - 摘要：The environmental characteristics of production place of authentic North Astragalus are summarized from the aspects of meteorological condition and ecological environment. The character structure of authentic North Astragalus is described from the aspects of intuitionistic and microcosmic. The medicinal value of the effective components of Astragalus is introduced,and the contents of effective components in authentic North Astragalus and other Astragalus membranaceus are compared. Based on above,the superiority of authentic North Astragalus as high quality and genuine Astragalus is expounded.关键词：authentic North Astragalus;production environment;character structure;effective components;medicinal value;review
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发布时间：2022-08-31
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