最新刊期
      期 2 ， 2018
      • LIU Fang,ZHOU Shengqiang,LIN Xiuhui,MA Ke,ZHOU Chunji,Instructor,LIU Zuyi
        Vol. 52, Issue 2, Pages: 2-5(2018) DOI: 10.16305/j.1007-1334.2018.02.001
        摘要：This paper summarizes national Chinese medical science master Liu Zuyi’s academic experience in treating neurologic impairment following brain injury from mutual promotion between yin and yang in brain marrow. It is considered that kidney is closely related to the growth and development of brain marrow,among,the promotion of kidney yang is crucial. Marrow depletion due to kidney deficiency is the pathological basis of central neurologic impairment,and yang qi is the key to the growth and development. According to the characteristics of brain governing spirit and yang qi regulating function,the viewpoint of “mutual promotion between yin and yang in brain marrow” is put forward,and the therapy of benefiting qi and warming yang,nourishing marrow and dredging collateral is used in the treatment of neurologic impairment following brain injury.  
          
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        发布时间：2022-08-31
      • TIAN Jianhui,LUO Bin
        Vol. 52, Issue 2, Pages: 6-10(2018) DOI: 10.16305/j.1007-1334.2018.02.002
        摘要：This paper explains the concept and characteristics of hidden toxicity in Chinese medical tumor,and discusses the biological connotation of hidden toxicity in lung cancer based on the occult tumor cells,such as circulating tumor cells,tumor stem cells,dormant tumor cells and so on. It is considered that the occult tumor cells are concealed and difficult to detect,they attack under the certain conditions,which similar to hidden toxicity in Chinese medicine. The discussion on modern biological basis of hidden toxicity could help to make clear the target of traditional Chinese medicine in the intervention on occurrence and metastasis of malignant tumor,and provide reference for precise treatment of traditional Chinese medicine. Meanwhile,it could further enrich Professor Liu Jiaxiang’s academic thoughts of strengthening vital qi to treat cancer,and also help to improve the clinical efficacy of traditional Chinese medicine.  
        关键词：lung cancer;hidden toxicity;circulating tumor cells;tumor stem cells;dormant tumor cells   
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        发布时间：2022-08-31
      • JIANG Jian
        Vol. 52, Issue 2, Pages: 11-16(2018) DOI: 10.16305/j.1007-1334.2018.02.003
        摘要：Nausea and vomiting are not only the symptoms of spleen and stomach diseases,but also the manifestations of liver(gallbladder)disease,heart disease and Class II spleen disease(spleen-heart disease) induced by excess of seven emotions,as well as the depression syndrome due to phlegm and fluid retention and static blood. Nausea and vomiting triggered or aggravated by emotional factors and treated effectively based on or combined with relieving depression,can be summarized as nausea and vomiting due to depression syndrome. It can be found in the mental psychological factors caused diseases with the symptoms of nausea and vomiting. Nausea and vomiting due to depression syndrome includes the single depression syndrome and coexistence of diseases and depression syndrome. For single depression syndrome,the location of disease is the liver,gallbladder,heart and spleen,not the stomach,which can be treated based on relieving depression. And for the coexistence of diseases and depression syndrome,which means the depression syndrome and spleen and stomach diseases exist at the same time,it should treat based on relieving depression and combined with regulation on the spleen and stomach.  
        关键词：Nausea;vomiting;etiology and pathogenesis;treatment based on relieving depression   
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        发布时间：2022-08-31
      • PAN Zhiqiang,QIAN Hongliang,WANG Xiaomin,LIANG Longlong,FANG Zhaoqin
        Vol. 52, Issue 2, Pages: 17-25(2018) DOI: 10.16305/j.1007-1334.2018.02.004
        摘要：Objective:To study the material basis of model mice with deficiency syndrome of qi,blood,yin and yang in viscera state of kidney. MethodsTaken the male ICR mice as objects,the model of syndrome of qi deficiency was replicated by dietary restriction method,the model of syndrome of blood deficiency was replicated by acetylphenylhydrazine,the model of syndrome of yin deficiency was replicated by thyroxine,the model of syndrome of yang deficiency was replicated by hydrocortisone. The body weight of mice was observed everyday,and the changes on different organs were compared. RNA was extracted in the kidney,adrenal and bone marrow tissue. The related gene expressions were detected by real time fluorescence quantitative PCR. The serum content of corticosterone was detected by ELISA.  Results:①Compared with the normal control group,the reduction on body weight of mice was most significant in the dietary restriction group(P<0.01),the body weight of mice in the acetylphenylhydrazine group and hydrocortisone group were also significantly decreased(P<0.05).The obvious atrophy in the spleen and thymus was observed in the dietary restriction group and hydrocortisone group(P<0.01),the significant swelling in the spleen and severe atrophy in the thymus were found in the acetylphenylhydrazine group(P<0.01). ②Compared with the normal control group,the serum level of corticosterone was significantly increased in the dietary restriction group and acetylphenylhydrazine group(P<0.05),while the serum level of corticosterone was significantly decreased in the hydrocortisone group(P<0.001). ③In the dietary restriction group,the mRNA expressions of Star,Cyp21a1 and Cyp11b1 in the adrenal gland were significantly increased(P<0.05),and the Epo mRNA expression in the kidney was significantly increased(P<0.05)and the Csf2 mRNA expression in the kidney significantly decreased(P<0.05),the mRNA expressions of Tpo and IL-4 in the bone marrow were significantly up-regulated(P<0.05). ④In the acetylphenylhydrazine group,the mRNA expressions of Cyp11a1,Cyp21a1 and Cyp11b1 in the adrenal gland were significantly increased(P<0.05),the mRNA expressions of Epo,Csf2 and Csf3 in the kidney were significantly increased(P<0.05),the mRNA expressions of Csf3,IL-4,IL-5 and IL-6 in the bone marrow were significantly increased,but the mRNA expressions of IL-1b and IL-7 in the bone marrow were significantly decreased(P<0.05). ⑤In the thyroxine group,the Cyp11b1 mRNA expression in the adrenal gland was significantly increased(P<0.05),the Epo mRNA expression was significantly increased and Csf2 mRNA expression was significantly decreased in the kidney(P<0.05),the mRNA expressions of Csf3,IL-2 and IL-5 in the bone marrow were significantly decreased(P<0.05). ⑥In the hydrocortisone group,the mRNA expressions of Star,Cyp21a1,Cyp11b1 and Cyp11b2 in the adrenal gland were significantly decreased(P<0.05),the Epo mRNA expression was significantly increased and mRNA expressions of Csf1 and Csf2 were significantly decreased in the kidney(P<0.05),the mRNA expressions of Csf3,IL-1b,IL-5 and IL-7 were significantly decreased and IL-4 mRNA expression was significantly increased in the bone marrow(P<0.05).  Conclusion:The related model of Chinese medical deficiency syndrome can be replicated by dietary restriction,administration of acetylphenylhydrazine,thyroxine and hydrocortisone. And there are corresponding changes on the material function in viscera state of kidney such as adrenal gland,kidney and bone marrow.  
        关键词：syndrome of qi deficiency;syndrome of blood deficiency;syndrome of yin deficiency;syndrome of yang deficiency;syndrome model;mice;viscera state of kidney;material basis   
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        发布时间：2022-08-31
      • ZHANG Bin,LI Ping,YANG Xinwei,XU Guangyao
        Vol. 52, Issue 2, Pages: 26-27(2018) DOI: 10.16305/j.1007-1334.2018.02.005
        关键词：breast diseases;therapy of traditional Chinese medicine;clinical experience;Zhu Songyi   
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        发布时间：2022-08-31
      • WANG Xiao,WANG Xiaoqun,LI Xiaojiang,Instructor,JIA Yingjie
        Vol. 52, Issue 2, Pages: 28-30(2018) DOI: 10.16305/j.1007-1334.2018.02.006
        摘要：This paper summarizes Professor Jia Yingjie’s clinical experience in treating lung cancer. It is considered that the disorder of qi movement in Sanjiao is the root of formation of cancer toxin. The treatments should regulate Sanjiao and harmonize qi movement,which combine with the products of clearing phlegm,protecting stomach and activating qi in Sanjiao according to condition.  
        关键词：lung cancer;Sanjiao;clinical experience;Jia Yingjie   
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        发布时间：2022-08-31
      • CHAI Shubin,CHEN Qingguang,QIU Yan,TAN Lingjie,LYU Lu,Instrutor,LU Hao
        Vol. 52, Issue 2, Pages: 31-34(2018) DOI: 10.16305/j.1007-1334.2018.02.007
        关键词：thyroid nodule;simple goiter;intermingled phlegm and blood stasis;clinical experience;Lu Hao   
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        发布时间：2022-08-31
      • LI Chongyu,WU Xiaoqiu,MA Zhaotian,LI Jun,Instructor,LIU Zhilong
        Vol. 52, Issue 2, Pages: 35-38(2018) DOI: 10.16305/j.1007-1334.2018.02.008
        摘要：This paper introduces Professor Liu Zhilong’s experience in the differentiation and treatment of type 2 diabetes with classic prescriptions. It is considered that the disease should make differentiation of yin and yang syndrome first,and differentiation of six meridians later,and then differentiation of zang-fu viscera,exterior-interior,cold-heat and deficiency-excess. And it is proposed that syndrome differentiation of six meridians and six types of Chinese medicines can be used in the treatment. One proven case is presented.  
        关键词：type 2 diabetes;syndrome differentiation of six meridians;clinical experience;Liu Zhilong   
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        发布时间：2022-08-31
      • JIN Guangliang
        Vol. 52, Issue 2, Pages: 39-41(2018) DOI: 10.16305/j.1007-1334.2018.02.009
        摘要：This paper explains the theory of “kidney suffers from dryness and can be moistened by pungent flavor drug”. The view that kidney suffers from dryness in Huangdi Neijing(Inner Canon of Huangdi)can be considered as one of the pathological features of the kidney. It means that kidney fails to transform qi due to deficiency of kidney qi and the fluid cannot be transported and distributed normally,which cause the dryness. The therapy of “moistening with pungent flavor drug” refers to drugs with pungent-flavor and warm-natured can help kidney to transform qi and further promote the transportation and distribution of fluid. Zhang Zhongjing in Eastern Han Dynasty applied Wuling Powder,Shenqi Pill,Gualou Qumai Pill and other recipes. Xu Shuwei and Cheng Wuji in Song and Jin periods discussed the pathogenesis of “kidney suffers from dryness” and the mechanism of “moistening with pungent flavor drug”. You Yi in Qing Dynasty divided the pathogenesis of dryness into the withered yin and coagulated yin. These support the above analysis from the clinical and theoretical aspects.  
        关键词：kidney suffers from dryness;moistening with pungent flavor drug;Huangdi Neijing(Inner Canon of Huangdi)   
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        发布时间：2022-08-31
      • YANG Wenzhe,ZHANG Zailiang
        Vol. 52, Issue 2, Pages: 42-47(2018) DOI: 10.16305/j.1007-1334.2018.02.010
        摘要：The cold pathogenic diseases in classical works have changed according to conditions in the clinical practice. The concept is changing and gradually abroad,the contents are expanded continuously,which mean the original cold pathogenic diseases has taken place the great changes in later clinic. The epidemic diseases lead to the medicine. In Late Eastern Han Dynasty,Shanghan Zabing Lun(Treatise on Cold Pathogenic and Miscellaneous Diseases)came from the historical background of the cold pathogenic diseases prevalence. From Jin Dynasty to Tang Dynasty,there were many famous experts,and the theory of cold pathogenic diseases presented the diversified development. The concept of cold pathogenic diseases changed in Song Dynasty,from disease to Shanghan Lun(Treatise on Cold Pathogenic Diseases),and there were many treatises. The attitude and standpoint of physicians in Ming and Qing Dynasty on Shanghan Lun could be divided into three kinds,which advocated revise or maintenance or treatment based on syndrome differentiation respectively. It promoted the rise of febrile diseases. The academic thoughts of modern physicians take the essence of theories of cold pathogenic diseases and febrile diseases in combination,and the summary on the syndrome and treatment of fever diseases is constantly improved.  
        关键词：cold pathogenic diseases;Zhang Zhongjing;Shanghan Zabing Lun(Treatise on Cold Pathogenic and Miscellaneous Diseases);concept;evolution   
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      • ZHANG Ziwei,CHEN Huijuan,LIANG Shanghua
        Vol. 52, Issue 2, Pages: 48-50(2018) DOI: 10.16305/j.1007-1334.2018.02.011
        摘要：The volume about women in Qianjin Fang(Recipes Worth A Thousand Gold)involves various diseases related to menstruation,leukorrhea,pregnancy and delivery. Sun Simiao considers that men and women are different and proposes gynecology. For infertility,he advocates the co-treatment for both men and women. During pregnancy, it should pay attention to fetal nourishment and antenatal training. The parturient women must keep quiet and are given the guidance of postpartum care. Sun’s medication is flexible and modified according to condition.He is good use of mineral medicine,animal medicine and wine.Sun’s treatments on emmeniopathy are flexible,and first creats the sequential therapy for infertility.The expelling cold and removing blood stasis are emphasized in postpartum diseases.  
        关键词：Sun Simiao;Qianjin Fang;gynecology;academic characteristics   
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      • YAO Liang,LI Jiayi,SHEN Yuanyuan,HE Xinhui
        Vol. 52, Issue 2, Pages: 51-54(2018) DOI: 10.16305/j.1007-1334.2018.02.012
        摘要：Objective:To observe the clinical efficacy of He’s Sangma Xingbei Decoction combined with western medicine in the treatment of acute exacerbation of chronic obstructive pulmonary disease(AECOPD). Methods60 AECOPD patients randomly divided into the treatment group and control group,30 cases in each group. The control group was treated with the conventional therapy of western medicine,and the treatment group was treated with He’s Sangma Xingbei Decoction combined with the conventional therapy of western medicine,with a course of 14 days. The clinical efficacy was observed,and the changes on the total score of coughing symptom,level of limulus amebocyte lysate test,pulmonary function indexes and dyspnea grades in modified British Medical Research Council(mMRC)questionnaire were compared.  Results:①The clinical total effective rates were 93.33% in the treatment group and 66.67% in the control group. The clinical efficacy of the treatment group was obviously better than that of the control group(P<0.05). ②After treatment,there were statistically significant differences on the total score of coughing symptom and level of FEV1(%)between the two groups,and the improvement in the treatment group was obviously better than that in the control group(P<0.05). ③In both groups,there was statistically significant difference on the level of limulus amebocyte lysate test between treatment before and after(P<0.05). For the D-value of level of limulus amebocyte lysate test between treatment before and after,there was statistically significant difference on the D-value between the two groups,and the D-value of the treatment group was greater than that of the control group(P<0.05). ④After treatment,there were statistically significant differences on the mMRC grades between the two groups,and the symptom improvement in the treatment group was obviously better than that in the control group(P<0.05).  Conclusion:He’s Sangma Xingbei Decoction combined with western medicine shows good efficacy in the treatment of acute exacerbation of chronic obstructive pulmonary disease,which can obviously improve the symptoms of airflow limitation in patients,effectively inhibit the acute inflammatory response and then help to control the illness as soon as possible.  
        关键词：chronic obstructive pulmonary disease;acute exacerbation stage;He’s Sangma Xingbei Decoction;inflammatory response;airflow limitation;phlegm-heat stagnating in lung   
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      • FENG Xin,HUANG Weiling,XU Chengxin
        Vol. 52, Issue 2, Pages: 55-57(2018) DOI: 10.16305/j.1007-1334.2018.02.013
        摘要：Objective:To observe the clinical efficacy of Bufei Huatan Yishen Quyu Recipe in the treatment of chronic obstructive pulmonary disease(COPD)in stable stage and its effects on serum level of D-Dimer. Methods80 COPD patients in stable stage were randomly divided into the treatment group and control group,40 cases in each group. The control group was treated with the conventional therapy of western medicine,and the treatment group was treated with Bufei Huatan Yishen Quyu Recipe based on the treatment for the control group. The changes on Chinese medical syndrome score,pulmonary function indexes and serum level of D-Dimer(D-D)were observed and compared.  Results:①Finally 75 cases completed the trial,among 39 cases in the treatment group and 36 cases in the control group. ②Compared with treatment before,the Chinese medical syndrome score was obviously decreased in both groups after treatment(P<0.05). The difference of Chinese medical syndrome score between treatment before and after in the treatment group was greater than that in the control group(P<0.05). ③In both groups,there were statistically significant differences on the levels of FVC and FEV1(%)between treatment before and after(P<0.05),but there was no statistically significant difference on the level of FEV1 between treatment before and after(P>0.05). There were no statistically significant differences on the levels of pulmonary function indexes between the two groups(P>0.05). ④Compared with treatment before,the D-D level was obviously decreased in the treatment group after treatment(P<0.05),but there was no statistically significant difference on the D-D level in the control group between treatment before and after(P>0.05). The difference of D-D level between treatment before and after in the treatment group was greater than that in the control group(P<0.05).  Conclusion:Bufei Huatan Yishen Quyu Recipe can obviously relieve the clinical symptoms of COPD patients in stable stage,decrease the serum level of D-Dimer and thus alleviate the chronic inflammatory state of COPD and improve the prognosis.  
        关键词：chronic obstructive pulmonary disease;stable stage;tonifying lung and resolving phlegm;benifiting kidney and removing blood stasis;chronic inflammatory state   
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        发布时间：2022-08-31
      • HU Chunlan,CHEN Guoying,CHU Aiqun,GAO Pengfei,DU Yuling,ZHANG Xiaohong,CEN Huizhong,GU Pinfang,CHEN Ling,HUANG Juhong
        Vol. 52, Issue 2, Pages: 58-61(2018) DOI: 10.16305/j.1007-1334.2018.02.014
        摘要：Objective:To observe the effects of traditional Chinese medicine(TCM)constitution intervention on patients with bronchial asthma in remission stage. Methods80 patients with bronchial asthma in remission stage were randomly divided into the treatment group and control group,40 cases in each group. The control group was treated with acupoint plastering therapy of compound recipe “Fujiutian”. Based on the treatment for the control group,the treatment group was additionally treated with Chinese medicine decoction according to constitution. The treatment course of both groups was one year with one-year follow-up. The changes on the clinical efficacy,asthma control test scale(ACT)score,serum immunoglobulin E(IgE)level,frequency of asthma attack within one year were observed.  Results:The clinical total effective rates were 95.0% in the treatment group and 80.0% in the control group. The clinical efficacy of the treatment group was significantly better than that of the control group(P<0.05). After treatment,the ACT score was obviously increased in both groups(P<0.05),and the IgE level was obviously decreased(P<0.05)and the frequency of asthma attack within one year was obviously reduced(P<0.05). After treatment,there were statistically significant differences on all indexes between the two groups(P<0.05).  Conclusion:The intervention program of acupoint plastering therapy of compound recipe “Fujiutian” combined with TCM constitution can obviously improve the clinical symptoms in patients with bronchial asthma in remission stage,enhance the quality of life and reduce the frequency of asthma attack.  
        关键词：bronchial asthma;remission period;TCM constitution;acupoint plastering   
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      • CEN Yi,ZHOU Jianhua,XU Zhuting
        Vol. 52, Issue 2, Pages: 62-66(2018) DOI: 10.16305/j.1007-1334.2018.02.015
        摘要：Objective:To observe the clinical efficacy and possible mechanism of therapy of tonifying kidney and resolving phlegm and clearing heat(Cupai Decoction)in the treatment of polycystic ovarian syndrome(PCOS)with insulin resistance(IR).Methods100 patients were randomly divided into the treatment group and control group,50 cases in each group.The treatment group was treated with the therapy of tonifying kidney and resolving phlegm and clearing heat(Cupai Decoction),and the control group was treated with metformin,folic acid and Vit B12. The treatment course in both groups was 5 months with five-month follow-up. The clinical efficacy was observed,and the changes on the oxidative stress related indexes,sex hormone related indexes and index of homeostasis model assessment for insulin resistance(HOMA-IR)were compared.  Results:①Finally 97 patients completed the trial,among 49 cases in the treatment group and 48 cases in the control group ②The clinical total effective rates were 89.8% in the treatment group and 25.0% in the control group. There was statistically significant difference on the clinical efficacy between the two groups,and the clinical efficacy of the treatment group was significantly better than that of the control group(P<0.05). ③After treatment,there were no statistically significant differences on the levels of superoxide dismutase (SOD) and malondialdehyde (MDA) between the two groups(P＞0.05)；but there was statistically significant difference on the glutathione peroxidase (GSH-Px) level between the two groups,and the GSH-Px level of the treatment group was obviously higher than that of the control group(P<0.05). After five-month follow-up,the levels of SOD and GSH-Px in the treatment group were significantly increased compared with treatment before,and the MDA level in the treatment group was significantly decreased compared with treatment before(P<0.05). After five-month follow-up,the MDA level of the treatment group was obviously lower than that of the control group(P<0.05). ④Compared with treatment before,the levels of testosterone (T),luteinizing hormone (LH) / follicle stimulating hormone (FSH) and HOMA-IR index were obviously decreased in the treatment group(P<0.05),and the HOMA-IR index was obviously decreased in the control group(P<0.05). After treatment,the T level of the treatment group was obviously lower than that of the control group(P<0.05). After five-month follow-up,the levels of T and LH/FSH in the treatment group were obviously decreased compared with treatment before(P<0.05). After five-month follow-up,the levels of T and LH/FSH in the treatment group were obviously lower than those in the control group(P<0.05),but there was no statistically significant difference on the HOMA-IR index between the two groups(P＞0.05). ⑤There was statistically significant difference on the incidence rate of adverse reaction between the treatment group and control group,and the incidence rate of treatment group(0/49)was obviously lower than that of the control group(8/48)(P<0.05).  Conclusion:The therapy of tonifying kidney and resolving phlegm and clearing heat(Cupai Decoction)shows good efficacy in the treatment of polycystic ovarian syndrome with insulin resistance. Its mechanism may be associated with the sustained and effective reduction on the level of oxidative stress in patients.  
        关键词：polycystic ovarian syndrome;insulin resistance;therapy of tonifying kidney and resolving phlegm and clearing heat;Cupai Decoction;oxidative stress   
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      • YUAN Ying,QIAN Xiaolu,YAN Wenmin,ZHOU Shuang
        Vol. 52, Issue 2, Pages: 67-70(2018) DOI: 10.16305/j.1007-1334.2018.02.016
        摘要：Objective:To observe the clinical efficacy of fire needle acupuncture in the treatment of dysphagia due to pseudobulbar paralysis after stroke. Methods76 patients with dysphagia due to pseudobulbar paralysis after stroke were randomly divided into the treatment group and control group,38 cases in each group. Based on the conventional therapy of western medicine,the treatment group was treated with fire needle acupuncture,and the control group was treated with the rehabilitation training for swallowing function,with a course of 30 days. The clinical efficacy was observed,the changes on the evaluation grades and pulse oximetry value in Kubota’s drinking water test and Chinese medical evaluation scale score on swallowing dysfunction were compared.  Results:①Finally 75 cases completed the trial,among 38 cases in the treatment group and 37 cases in the control group. ②The clinical total effective rates were 89.5% in the treatment group and 75.7% in the control group. The clinical efficacy of the treatment group was obviously better than that of the control group(P<0.05). ③After treatment,there were statistically significant differences on the evaluation grades of Kubota’s drinking water test between the two groups,and the improvement on the swallowing function in the treatment group was obviously better than that in the control group(P<0.05). ④For the comparison of the difference of pulse oximetry value between before and after Kubota’s drinking water test,there was statistically significant difference on the decreased value of pulse oximetry value between the two groups after treatment,and the improvement on the mistaken aspiration in the treatment group was obviously better than that in the control group(P<0.05). ⑤After treatment,there was statistically significant difference on the Chinese medical evaluation scale score of swallowing dysfunction between the two groups,and the score of the treatment group was significantly lower than that of the control group(P<0.05).  Conclusion:Fire needle acupuncture shows good efficacy in the treatment of dysphagia due to pseudobulbar paralysis after stroke,which is better than conventional rehabilitation training. It can obviously improve the dysphagia in patients and reduce the mistaken aspiration during diet and drinking.  
        关键词：stroke;pseudobulbar paralysis;neurogenic dysphagia;fire needle;blood oxygen saturation   
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      • JI Renxin,YU Bo,HE Fei,MIAO Yun,CHEN Wenhua
        Vol. 52, Issue 2, Pages: 71-74(2018) DOI: 10.16305/j.1007-1334.2018.02.017
        摘要：Objective:To observe the clinical efficacy of modified kinesio taping of integrated Chinese and western medicine in the treatment of knee osteoarthritis. Methods150 patients with knee osteoarthritis were randomly divided into the external treatment group of Chinese medicine(Chinese medicine group),external treatment group of western medicine(western medicine group) and integrated Chinese and western medicine group(integrated group),50 cases in each group. The Chinese medicine group was treated with Huangjing Xinshang Ointment,the western medicine group was treated with kinesio taping,and the integrated group was treated with the modified kinesio taping of integrated Chinese and western medicine,with a course of 14 days. The changes on the active range of motion(AROM)in knee and Western Ontario and McMaster Universities(WOMAC)osteoarthritis indexes were observed and compared.  Results:①For the comparison of treatment before and after,there was statistically significant difference on the flexion angle in the Chinese medicine group(P<0.05),and there were statistically significant differences on the angles of flexion,internal rotation and external rotation angle in the western medicine group and integrated group(P<0.05). After treatment,the improvements on the angles of flexion,internal rotation and external rotation angle in the western medicine group and integrated group were obviously better than those in the Chinese medicine group(P<0.05). While there were no statistically significant differences on the angles of flexion,internal rotation and external rotation angle between the western medicine group and integrated group(P＞0.05). ②For the comparison of treatment before and after,there was statistically significant difference on the score of pain in all groups(P<0.05),and there were statistically significant differences on the scores of stiffness and daily activity difficulty in the western medicine group and integrated group(P<0.05),but there were no statistically significant differences on the scores of stiffness and daily activity difficulty in the Chinese medicine group(P＞0.05). After treatment,the scores of pain and daily activity difficulty in the integrated group were obviously lower than those in the western medicine group and Chinese medicine group(P<0.05),the score of stiffness in the western medicine group and integrated group was obviously lower than that in the Chinese medicine group(P<0.05),and there was no statistically significant difference on the score of stiffness between the western medicine group and integrated group(P＞0.05).  Conclusion:Modified kinesio taping of integrated Chinese and western medicine shows good efficacy in the treatment of knee osteoarthritis,which can obviously improve the active range of motion in knee joint of patients,and relieve the symptoms such as pain,stiffness and so on.  
        关键词：knee osteoarthritis;degenerative disease of knee joint;integrated Chinese and western medicine;kinesio taping;Huangjing Xinshang Ointment   
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        发布时间：2022-08-31
      • WU Shengnan,TANG Qianyu,YU Erkai
        Vol. 52, Issue 2, Pages: 75-80(2018) DOI: 10.16305/j.1007-1334.2018.02.018
        摘要：Objective:To observe the effects of Bushen Shugan Huoxue Recipe on menstrual volume and endometrium thickness in patients with hypomenorrhea following artificial abortion. Methods80 patients with hypomenorrhea following artificial abortion were randomly divided into the observation group and control group,40 cases in each group. The observation group was treated with Bushen Shugan Huoxue Recipe,and the control group was treated with sequential therapy of estrogen and progesterone,with a course of 3 menstrual cycles and 3-month follow-up. The changes on the Chinese medical syndrome scores,menstrual volume and endometrium thickness were observed.  Results:①Compared with treatment before,the scores on menstrual color and quality,soreness and weakness of waist and knee,breast swelling pain were decreased in both groups after treatment(P<0.05). After treatment,the total score and single score of menstrual color and quality,soreness and weakness of waist and knee,breast swelling pain in the observation group were lower than those in the control group(P<0.05). ②Compared with treatment before,the menstrual volume and endometrium thickness were obviously increased in both groups after treatment(P<0.05). After treatment,the menstrual volume and endometrium thickness in the observation group were greater than those in the control group(P<0.05).  Conclusion:Bushen Shugan Huoxue Recipe shows good clinical efficacy on hypomenorrhea following artificial abortion. It can obviously increase the menstrual volume and endometrium thickness of patients,which is worthy of clinical application.  
        关键词：following artificial abortion;hypomenorrhea;Bushen Shugan Huoxue Recipe;menstrual volume;endometrium thickness   
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      • JI Li,ZHANG Tingting,DENG Xian,LI Rongqun
        Vol. 52, Issue 2, Pages: 81-83(2018) DOI: 10.16305/j.1007-1334.2018.02.020
        摘要：This paper explains the therapeutic effects of contrary compatibility on systemic lupus erythematosus,including the origin,connotation and application in the classic prescriptions. And one proven case is presented.  
        关键词：systemic lupus erythematosus;compatibility;contrary method;Shengma Biejia Decoction;Baihu Guizhi Decoction;Shenqi Pill   
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      • ZHAO Xingyu,HOU Yisen,LIU Yafan,HOU Jiancheng,ZHANG Xiaoyu,ZHANG Wei
        Vol. 52, Issue 2, Pages: 84-88(2018) DOI: 10.16305/j.1007-1334.2018.02.021
        摘要：Objective:To study the effects of 6-Shogao at different concentrations on the apoptosis of human gastric cancer BGC-823 cells,and discuss its mechanism. MethodsThe BGC-823 cells were treated with 6-Shogao at concentrations of 0,10,20 and 50 μmol/L for 24 hours,respectively. The morphological changes of cells were observed by inverted microscope. The viability of BGC-823 cells in each group was detected by MTT assay. The early apoptosis rate was detected by flow cytometry. The changes on the expression of apoptosis related proteins including P53,cleaved-poly ADP-ribose polymerase-1(cleaved-PARP-1),pro-cysteinyl aspartate specific proteinase-3(pro-Caspase-3)and cleaved-Caspase-3 were detected by Western blot.  Results:6-Shogao showed the significant inhibitory effect on the growth of BGC-823 cells. Compared with the control group,the inhibition rate and early apoptosis rate of cells were increased significantly in the 6-Shogao-treated groups with different concentrations(P<0.05,P<0.01),in a concentration-dependent manner. The results of Western blot showed that 6-Shogao could increase the protein expressions of P53,cleaved-Caspase-3 and cleaved-PARP-1 and decrease the pro-Caspase-3 protein expression in BGC-823 cells(P<0.05,P<0.01).  Conclusion:6-Shogao can induce BGC-823 cells apoptosis. Its mechanism may be associated with Caspase-3 mediated apoptosis pathway.  
        关键词：6-Shogao;BGC-823 cells;cell proliferation;cell apoptosis;caspase-3   
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        发布时间：2022-08-31
      • ZHANG Ruijuan,YU Qianyun,LI Chaoheng,JIANG Wei,XU Jianhua
        Vol. 52, Issue 2, Pages: 89-94(2018) DOI: 10.16305/j.1007-1334.2018.02.022
        摘要：Objective:To study the effects of Changweiqing Decoction on DNA double-strand damage and homologous recombination repair factor ATM and γH2AX in nude mice with subcutaneous xenografts of colon cancer . MethodsThe subcutaneous xenografts model was established in the nude mice by human colon cancer cell line(HCT116). The nude mice were divided into the blank group,oxaliplatin(L-OHP) group,Changweiqing group and Changweiqing plus L-OHP group(combination group). The drug treatment groups were treated with L-OHP,Changweiqing Decoction and Changweiqing Decoction plus L-OHP,respectively. The degree of DNA damage was detected by comet assay. The expressions of homologous recombination factor ATM and γH2AX were detected by Western blot and immunohistochemistry.  Results:Compared with the blank group,the tailing phenomenon was observed in the Changweiqing group,L-OHP group and combination group,and the tailing phenomenon was more significant in the combination group(P<0.05). Compared with the blank group,the protein expressions of ATM and γH2AX were obviously up-regulated in the L-OHP group and combination group(P<0.05). Compared with the L-OHP group,the protein expressions of ATM and γH2AX were obviously down-regulated in the combination group(P<0.05,P<0.01).  Conclusion:The most serious damage of DNA double-strand breaks can be observed in the Changweiqing plus L-OHP group,which suggests that Changweiqing Decoction can enhance the efficacy of L-OHP. Its mechanism is to reduce the homologous recombination repair effects of colon cancer cells on the chemotherapy damage.  
        关键词：colon cancer;Changweiqing;oxaliplatin;DNA double-strand damage;homologous recombination repair   
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        发布时间：2022-08-31
      • LI Ruiling,LU Xinling,XIONG Ye,WU Yansheng,LIU Weiwei,SHI Liqiang,GAO Jiandong
        Vol. 52, Issue 2, Pages: 95-98(2018) DOI: 10.16305/j.1007-1334.2018.02.023
        摘要：Objective:To explore the effects of acupuncture combined with Shizhi Recipe on the uric acid(UA)and xanthine oxidase(XOD)activity in hyperuricemia rats with renal damage. Methods50 male SD rats of clean grade were selected and randomly divided into the normal group,model group,Chinese medicine(Shizhi Recipe)group,western medicine(allopurinol)group and acupuncture-drug(acupuncture plus Shizhi Recipe)group,10 rats in each group. The model was established by oteracil potassium at dose of 750 μg·g-1·d-1 by intragastric administration. After modeling,the treatments were performed in the everyday afternoon. The normal and model group were treated with distilled water at volume of 2 ml by intragastric administration,the Chinese medicine group was treated with Shizhi Recipe by intragastric administration,the western medicine group was treated with allopurinol by intragastric administration,and the acupuncture-drug group was treated with Shizhi Recipe and acupuncture. The acupuncture was performed at Pishu(B20),Shenshu(B23),Zusanli(S36)and Sanyinjiao(SP6)acupoints once every other day,and the retaining of needle was 30 minutes each time. After treatment for continuous 4 weeks,the levels of serum UA,serum creatinine(Scr),blood urea nitrogen(BUN),blood lipid indicators,24 h urinary UA,24 h urinary protein and XOD activities in the serum,liver and kidney of rats in each group were detected.  Results:Compared with the normal group,the levels of serum UA and 24 h urinary UA and the XOD activity were obviously increased in the model group,with statistically significant differences(P<0.05),but there were no statistically significant differences on the levels of BUN and Scr between the normal and model group(P<0.05),which suggested that the hyperuricemia model was successfully established. Compared with the model group,the serum UA level was significantly decreased and the total excretion of 24 h urinary UA was significantly increased and the XOD activities in the serum,liver and kidney were significantly decreased in the Chinese medicine group,western medicine group and acupuncture-drug group,with statistically significant differences(P<0.05),which suggested that all these treatments showed therapeutic effects. There were statistically significant differences on the levels of serum UA,24 h urinary UA,triacylglycerol and cholesterol and the XOD activities in the serum,liver and kidney between the Chinese medicine group and acupuncture-drug group(P<0.05),which suggested that the related efficacy of the acupuncture-drug group was better than that of the Chinese Medicine.  Conclusion:The combined acupuncture-drug therapy can effectively reduce the serum uric acid level and promote the urinary uric acid excretion in hyperuricemia rats with renal damage,improve the level of lipid metabolism and reduce the activities of XOD in serum,liver and kidney,which may be one of its mechanisms on the reduction of blood uric acid.  
        关键词：hyperuricemia;renal damage;acupuncture;Shizhi Recipe;xanthine oxidase   
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        发布时间：2022-08-31
      • LI Anqi,LIU Yijie,FENG Wei,HE Dongyi,ZHANG Zengqiao,HU Xiaoshen,YANG Songbin,ZHANG Cai
        Vol. 52, Issue 2, Pages: 99-103(2018) DOI: 10.16305/j.1007-1334.2018.02.024
        摘要：Objective:To investigate the effects of icariin (ICA) on the phenotype of interleukin-1β (IL-1β)-induced inflammatory chondrocytes. MethodsThe articular chondrocytes of rats were isolated and cultured. The primary chondrocytes were induced by IL-1β,and the inflammatory environment of chondrocytes in osteoarthritis was simulated. The cells were divided into the blank group,model group(treated with IL-1β at concentration of 10 mg/L),ICA group with low-concentration(treated with IL-1β at concentration of 10 mg/L and ICA at concentration of 1 μmol/L)and ICA group with high-concentration(treated with IL-1β at concentration of 10 mg/L and ICA at concentration of 5 μmol/L).The protein expressions of collagen-II and aggrecan were detected by Western blot. The mRNA expressions of collagen-II,aggrecan,matrix metallopeptidase-13(MMP-13)and a disintegrin and metalloprotease with thrombospondin motifs-5(ADAMTS-5)were detected by RT-PCR.  Results:After the cells were cultured for three day,compared with the model group,ICA could obviously promote the mRNA and protein expressions of collagen-II in the inflammatory chondrocytes(P<0.05)；and this effect in the ICA group with high-concentration was more significant than that in the ICA group with low-concentration(P<0.05). Compared with the model group,ICA could obviously promote the mRNA and protein expressions of aggrecan in the inflammatory chondrocytes(P<0.05)；and this effect shows no obviously difference between the low- and high-concentration. Compared with the model group,ICA could inhibit the mRNA expressions of MMP-13 and ADAMTS-5(P<0.05),and the inhibiting effect on MMP-13 mRNA expression was more significant in the ICA group with high-concentration(P<0.05)；there was no obvious difference on the ADAMTS-5 mRNA expression between the low- and high-concentration.  Conclusion:ICA can inhibit the expressions of MMP-13 and ADAMTS-5 and promote the expressions of collagen-II and aggrecan in the inflammatory chondrocytes,and thus maintain the chondrocytes phenotype and promote the matrix metabolism.  
        关键词：icariin;Osteoarthritis;chondrocytes   
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      • TAN Zhaodan,CHEN Weicheng,GAO Yang,LUO Lan,SHI Kourong,GU Weiying
        Vol. 52, Issue 2, Pages: 104-108(2018) DOI: 10.16305/j.1007-1334.2018.02.025
        摘要：Objective:To study the difference on contents of key components in formula granule,single and mixed decoction of Huanglian(Coptidis Rhizome)and Wuzhuyu(Evodiae Fructus)with equal proportion,and explore the equivalence of formula granule and traditional decocting method in couplet medicines. MethodsThe contents of 6 kinds alkaloids in formula granule,single and mixed decoction were determined by HPLC,including berberine,coptisine,palmatine,epiberberine,rutacarpine and evodiamine,and the statistics analysis was performed by SPSS18.0.  Results:There was obvious differences on the contents of coptis alkaloids. The contents of berberine were(0.64±0.07)% in the mixed decoction and(1.29±0.17)% in the single decoction；compared with the mixed decoction,the content of berberine was significantly increased in the single decoction(P<0.001). The contents of coptisine were(0.45±0.05)% in the mixed decoction and(0.33±0.04)% in the single decoction；compared with the mixed decoction,the content of coptisine was significantly decreased in the single decoction(P=0.020). The contents of palmatine were(0.48±0.03)% in the mixed decoction and(0.36±0.03)% in the single decoction；compared with the mixed decoction,the content of palmatine was significantly decreased in the single decoction(P=0.002). The contents of epiberberine were(0.30±0.03)% in the mixed decoction and(0.23±0.03)% in the single decoction；compared with the mixed decoction,the content of epiberberine was significantly decreased in the single decoction(P=0.017). The content of palmatine was(0.42±0.03)% in the formula granule,which was slightly decreased compared with the mixed decoction(P=0.038). There were no obvious differences on the contents of berberine,coptisine and epiberberine between the formula granule and mixed decoction(P>0.05).There were no statistically significant differences on the contents of rutacarpine and evodiamine among formula granule,single and mixed decoction(P>0.05).  Conclusion:There was no significant difference between the formula granule and mixed decoction of Huanglian(Coptidis Rhizome)and Wuzhuyu(Evodiae Fructus). But there were obvious differences on the contents of coptis alkaloids between the single and mixed decoction.  
        关键词：Huanglian(Coptidis Rhizome);Wuzhuyu(Evodiae Fructus);formula granule;mixed decoction;single decoction;components comparison   
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      • LI Yulin,CHU Lixi
        Vol. 52, Issue 2, Pages: 109-113(2018) DOI: 10.16305/j.1007-1334.2018.02.026
        摘要：This paper reviews the biomechanical effects of open and close chain exercises on knee joint after reconstruction of autologous hamstring tendon grafts. By searching and collecting the relevant literatures,it finds that in the open chain exercises,with the increase of knee flexion angle,when the quadriceps femoris contracts separately, the load of anterior cruciate ligament shows the tread of first increase and then decrease；when the hamstring contracts separately,the load of anterior cruciate ligament is gradually decreased. While in the close chain exercises,the standard squat training produces a few or no load on the anterior cruciate ligament,which can be reduced by getting the heel on the ground or increasing the trunk anteversion；compare with the both legs squat,the load peak of anterior cruciate ligament in single leg squat is greater. In the close chain leg-press,the height of the feet and the width of the support surface show no effects on the load of anterior cruciate ligament.  
        关键词：open kinetic chain exercises;close kinetic chain exercise;biomechanics;review   
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        发布时间：2022-08-31
      • ZHU Hongyan,ZHANG Di,ZHOU Limei,JIN Xin,JIANG Ran,ZHAO Yan,HE Zhongmei,GAO Yugang,ZHANG Lianxue
        Vol. 52, Issue 2, Pages: 114-117(2018) DOI: 10.16305/j.1007-1334.2018.02.027
        摘要：By consulting Chinese and foreign literatures,this paper summarizes the pharmacological effects of gastrodigenin.Gastrodigenin not only shows the central neuropharmacological effects such as sedation,hypnotism,anti-convulsion and improving learning and memory ability,but also presents the anti-inflammatory and anti-tumor activities as well as certain protection on cerebral ischemia.  
        关键词：gastrodigenin;central nervous system;anti-inflammation;anti-tumor;review   
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