最新刊期
期 12 ， 2018
- 摘要：This paper introduces Professor Xu Rongjuan’s clinical experience in treating diabetes insipidus with therapy of clearing upper energizer and warming lower energizer. It is considered that heat in upper energizer and cold in lower energizer are the primary pathogenesis of diabetes insipidus. The treatment should be based on clearing dryness-heat in the lung and stomach and warming deficient yang in kidney,which can combine with various warming yang methods,such as warming and astringing,warming and nourishing yin,warming and suppressing yang, warming and tonifying qi,warming and resolving dampness,warming and reconciling Shaoyang disorder. The commonly used drugs include Shigao(Gypsum Fibrosum),Zhimu(Anemarrhenae Rhizoma),Huanglian(Coptidis Rhizoma),Shanyao(Dioscoreae Rhizoma),Fuzi(Aconiti Lateralis Preparata Radix)and so on. One proven case is presented.关键词：diabetes insipidus;clearing upper energizer and warming lower energizer;experience of famous doctor;Xu Rongjuan
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发布时间：2022-08-31 - 摘要：“Jin Gu Theory”(theory of muscles and bones)originates from Huangdi Neijing(Inner Canon of Huangdi), and is throughout the discipline development of Chinese medical tuina. “Dislocation of Jin and Gu” is the main pathological understanding and theoretical core of spinal injuries in traditional Chinese medicine. Modern research has provided some evidence for the scientific nature of “Jin Gu Theory” in traditional Chinese medicine. “Jin Gu Theory” effectively guides the clinical practice of Chinese medical tuina in spinal joint injuries. And as the main content of Chinese medical tuina palpation examination,evaluation on muscles and bones can be used not only for the early diagnosis of diseases,but also for guiding the selection of tuina techniques and treatment sites. The paper tries to further clarify the development of “Jin Gu Theory” and explore the theoretical basis of evaluation on muscles and bones,which could provide references for the clinical and scientific research of Chinese medical tuina.关键词：Tuina;“Jin Gu Theory”;development;evaluation on muscles and bones
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发布时间：2022-08-31 - 摘要：Infertility that caused by excess seven emotions induced internal injuries can be called as infertility due to depression syndrome. Emotional stagnation and stagnation of liver qi are most likely to affect menstruation,or lead to infertility,or even abortion. Adjusting emotion can also regulate the menstruation and pregnancy. The treatment methods include suppressing qi and nourishing blood to reduce the mood of joy and anger,adjusting meridians and regulating spleen to remove the mood of depression and jealousy,nourishing blood for tranquillization and keeping the peaceful mind,and nourishing yin and cooling blood to inhibit ministerial fire. In addition,psychological therapy and other non-drug treatments are also very important. Modern psychosomatic medicine such as psychogenic infertility,as well as part of ovulation dysfunction,luteal phase defect,luteinizing unruptured follicle syndrome and other infertility,which involved mental and psychological factors,probably belong to the category of infertility due to depression syndrome.关键词：depression syndrome;infertility;inernal injuries caused by excess seven emotions;treatment based on relieving depression
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发布时间：2022-08-31 - 摘要：Objective:To screen the clinical diagnostic indications of wind syndrome of Taiyin,and explore the research methods of standardization of TCM syndrome diagnosis. MethodsHuangqi Guizhi Wuwu Decoction,as the main prescription of wind syndrome of Taiyin,was taken as the object to retrieve relevant literatures and extract information about four diagnostic methods,and the database was established. The UCINET software was used for data processing and complex network construction,and the preliminary clinical diagnostic indications of wind syndrome of Taiyin were filtered. Then the final diagnostic indications were obtained combined with the original text and clinical practice. Results:The main symptoms of Huangqi Guizhi Wuwu Decoction screened by complex network were light tongue,white fur,thin fur,thready pulse,numbness,weakness,sweating and aversion to cold,the secondary symptoms were deep pulse,feeble pulse,slight red fur,limbs pain,spiritlessness,anorexia,shortness of breath,gloomy complexion,dizziness,ache and pale complexion. The main symptoms of the clinical diagnostic indications of wind syndrome of Taiyin were limbs or trunk pain,spiritlessness and weakness,sweating,aversion to cold,light tongue,thin fur,white fur and thready pulse,the secondary symptoms were anorexia,shortness of breath,dizziness,gloomy complexion,pale complexion,deep pulse and feeble pulse. Conclusion:The clinical diagnostic indications of wind syndrome of Taiyin screened by complex network can provide reference for deeper understanding and clinical diagnosis of wind syndrome of Taiyin.关键词：wind syndrome of Taiyin;diagnostic indication;Huangqi Guizhi Wuwu Decoction;complex network;visualization;four diagnostic information
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发布时间：2022-08-31 - 摘要：Objective:To analyze the application characteristics and rules of the meridians and acupoints of acupuncture and moxibustion in the treatment of chronic obstructive pulmonary disease by data mining technology. MethodsThe database of acupuncture-moxibustion prescriptions was established by collecting the modern literatures about the treatment of chronic obstructive pulmonary disease with acupuncture and moxibustion. The application characteristics and rules of the meridians and acupoints in the treatment of chronic obstructive pulmonary disease with acupuncture and moxibustion were analyzed by association rules in data mining technology. Results:①A total of 104 prescriptions of acupuncture and moxibustion for treating chronic obstructive pulmonary disease were collected, including 51 acupoints and 552 total application frequency, and the acupoints of bladder meridian, conception vessel and stomach meridian were the most frequently used acupoints. ②The local selection of acpoints was dominant. Among them, the acupoints on the back and chest and abdomen accounted for 47.46% and 17.03% of the total acupoints, respectively. The higher application frequency was Feishu (BL13), Zusanli (ST36), Dingchuan (EX-B1) and Shenshu (BL23) acupoints in turn. ③The selection of specific acupoints showed absolute advantage, which accounted for 83.7% of the selected acupoints. The higher application frequency was back-shu point, crossing points and five-shu points in turn, and the supportive degree between five-shu points and crossing points was the highest. Conclusion:It is reasonable and feasible to apply data mining technology in modern clinical literature research of acupuncture and moxibustion for treating chronic obstructive pulmonary disease, which can provide the basis for modern clinical research and treatment.关键词：chronic obstructive pulmonary disease;acupuncture and moxibustion therapy;data mining;acupoint application characteristics
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发布时间：2022-08-31 - 摘要：This paper analyzes Chen Jianjie’s clinical experience in treating chronic hepatitis B with herbal paste. It is considered that the prescriptions should be in accordance with seasonal conditions,local conditions and patient’s individuality,and the medication should be cautious. The treatment should be regulating liver as key and combined with,spleen and kidney,which is based on harmony and takes reinforcement and elimination in combination. The accompanying symptoms can not be neglected and can be treated combined with main syndrome. And one proven case is presented.关键词：chronic hepatitis B;herbal paste;experience of physician;Chen Jianjie
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发布时间：2022-08-31 - 摘要：This paper discusses Professor Lyu Xiong’s experience in treating diabetic skin pruritus with therapy of harmonizing liver and spleen. It is believed that long-term diabetes can cause disorder of visceral-qi and disharmony between liver and spleen,which induces turbid toxin. Stagnation of turbid toxin transforms into heat,and the heat transmits through the skin meridians,which leads to skin pruritus. The treatment is based on dispersing stagnated liver qi and clearing heat and resolving turbidity. Modified Shuhe Drink can be used. And one proven case is presented.关键词：diabetic skin pruritus;Shuhe Drink;experience of famous doctor;Lyu Xiong
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发布时间：2022-08-31 - 关键词：lung cancer;deep vein thrombosis;Huangqi Guizhi Wuwu Decoction;experience of famous physician;Zhao Yuanhong
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发布时间：2022-08-31 - 关键词：polycystic ovarian syndrome;clinical experience;classical prescriptions;etiology and pathogenesis;modern research
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发布时间：2022-08-31 - 摘要：This paper discusses the significance of opposite and complementary compatibility thinking from the aspects of concepts and classification, purpose and application, and complex situation of combined application of cold- and warm-natured Chinese medicine. Combined application of cold- and warm-natured Chinese medicine is one of the most commonly used methods of prescriptions compatibility under the guidance of opposite and complementary compatibility thinking. Through the opposite and complementary relationship between the cold and the warm, the prescriptions as the organic whole could correspond to the cold and hot characters of the diseases. There are three implications for the combined application of cold- and warm-natured Chinese medicine. First, it aims to restrict the cold or hot partiality of certain medicine to achieve the purpose of successfully exerting the certain specific effect. Second, through the mutual restriction of cold- and warm-natured medicine, the compatible prescriptions and couplet medicines would not be too cold or too hot, so as to better adapt to the conditions and prevent from adverse reactions caused by excessive cold and heat. The third is to produce new efficacy that is not possessed by single cold-natured medicine or hot-natured medicine.关键词：combined application of both cold- and warm-natured Chinese medicine;opposite and complementary;compatibility thinking
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发布时间：2022-08-31 - 摘要：This paper analyzes the diagnosis and treatment characteristics of consumptive diseases in Bianzheng Lu. For the syndrome differentiation on consumptive diseases, Chen Shiduo emphasizes the sexual life and emotional factors. The detailed symptoms are focused combined with the pulse, and the differentiation is emphasized. Based on the theory of mutual generation and restriction of five phases,the syndrome differentiation of zang-fu viscera is performed. For the treatment,tonifying yin to restrict yang is used,which should protect yin fluid during the whole course. It is emphasized that the stomach is the gate of the kidney,and replenishing the essence needs to tonify spleen and regulate stomach. It is considered that the heart is a vital organ like the king of the body,and heart deficiency should tonify the five zang viscera. Chen’s medication is mainly replenishing blood and nourishing yin medicines. His medication is accurate and appropriate, and the channel ushering drugs are made good use. And the treatment time is paid attention, the course of medication should be guaranteed, and the prescriptions should be modified timely.关键词：consumptive disease;Bianzheng Lu;Chen Shiduo;characteristics
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发布时间：2022-08-31 - 摘要：Objective:To observe the clinical efficacy of therapy of integrated traditional Chinese and western medicine by stages in treating bronchial asthma in children. Methods80 children with bronchial asthma were randomly divided into the treatment group and control group, 40 cases in each group. The control group was treated with western medicine according to GINA guidelines. The treatment group was treated with integrated traditional Chinese and western medicine by stages, with a treatment course of four and a half months and follow-up for one year. The clinical efficacy was observed, and the changes of main symptoms and signs scores and lung function indexes were compared, and the children asthma control test (C-ACT) questionnaire score was used to assess and compare the long-term control level of asthma. Results:①The total effective rates were 92.5% in the treatment group and 87.5% in the control group. The clinical efficacy of the treatment group was better than that of the control group, but with no statistically significant difference (P>0.05). ②Compared with treatment before, the main symptoms and signs scores were obviously decreased in both groups after treatment for one and a half months and at the end of treatment, with statistically significant differences (P<0.05). After treatment for one and a half months, the main symptoms and signs scores in the treatment group were significantly lower than those in the control group (P<0.05). At the end of the treatment, the main symptoms and signs scores in the treatment group were significantly lower than those in the control group (P<0.05). ③Compared with treatment before, the C-ACT score was significantly increased in both groups at the end of the treatment, after follow-up for 6 months and 1 year, respectively (P<0.05). Compared between the end of the treatment and follow-up for 1 year, the C-ACT score in the control group was significantly decreased (P<0.05), while no statistically significant difference on C-ACT score was observed in the treatment group (P>0.05). The C-ACT score in the treatment group was obviously higher than that in the control group after follow-up for 1 year (P<0.05). ④Compared with treatment before, the levels of FEV1% and PEF% were significantly increased in both groups at the end of the treatment, with statistically significant differences (P<0.05). At the end of the treatment, there were no statistically significant differences on the levels of FEV1% and PEF% between the two groups (P>0.05). Conclusion:At the whole stage of bronchial asthma in children, the therapy of integrated traditional Chinese and western medicine by stages shows equivalent clinical efficacy with western medicine therapy, while the therapy of integrated traditional Chinese and western medicine by stages shows advantages in improving symptoms and signs in the chronic persistent phase and clinical remission stage and enhancing long-term efficacy of asthma controlling during follow-up.关键词：childhood asthma;integrated traditional Chinese and western medicine;treatment by stages;disease control;C-ACT score;long-term efficacy
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发布时间：2022-08-31 - 摘要：Objective:To observe the clinical efficacy of auricular point pressing combined with western medicine in the treatment of essential hypertension in community. Methods180 patients of essential hypertension in community were randomly divided into the treatment group and control group, 90 cases in each group. The control group was orally treated with single hypotensive drug, and the treatment group was treated with therapy of auricular point pressing based on oral administration of single hypotensive drug, with a course of 5 months. The clinical efficacy was observed, the changes of blood pressure related indicators (systolic pressure, diastolic pressure, pulse pressure) were compared. Results:①Finally, 79 cases in the control group and 87 cases in the treatment group completed the trial. ②The total effective rates were 85.1% in the treatment group and 58.2% in the control group. The clinical efficacy of the treatment group was significantly better than that of the control group (P<0.05). ③Compared with treatment before, the systolic pressure, diastolic pressure and pulse pressure were obviously decreased in the treatment group after treatment, with statistically significant differences (P<0.05), and the systolic pressure, diastolic pressure and pulse pressure in the control group showed the decreasing tendency, but with no statistically significant differences (P>0.05). After treatment, the systolic pressure, diastolic pressure and pulse pressure in the treatment group were significantly lower than those in the control group (P<0.05). ④In the treatment group, the decrease of systolic pressure in patients with syndrome of excessive phlegm-dampness was greater than that in patients with syndrome of deficiency of both yin and yang (P<0.05), there was no statistically significant difference among other syndromes (P>0.05). The decrease of diastolic pressure in patients with syndrome of exuberance of liver fire was greater than that in patients with syndrome of hyperactivity of yang due to yin deficiency (P<0.05), there was no statistically significant difference among other syndromes (P>0.05). After treatment, there was no statistically significant difference on the decrease of pulse pressure among different syndromes (P>0.05). Conclusion:The therapy of auricular point pressing combined with western medicine shows satisfactory efficacy in the treatment of essential hypertension, which can more effectively lower blood pressure (systolic pressure, diastolic pressure and pulse pressure) compared with western medicine alone, and according to the different TCM syndrome patterns of patients, there are some differences in the effect of blood pressure lowering.关键词：essential hypertension;community people;auricular point;non-drug therapy;meridians and collaterals;syndrome of exuberance of liver fire;syndrome of excessive phlegm-dampness
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发布时间：2022-08-31 - 摘要：Objective:To observe the clinical efficacy of Chinese medicine physical and breathing exercise for calculi removal combined with Zhou’s calculi removal decoction (drug-exercise combination therapy) in the treatment of upper urinary tract calculi with syndrome of dampness-heat diffused downward. Methods158 patients of upper urinary tract calculi with syndrome of dampness-heat diffused downward were randomly divided into the treatment group and the control group, 79 cases in each group. The treatment group was treated with Zhou’s calculi removal decoction combined with Chinese medicine physical and breathing exercise forcalculi removal (drug-exercise combination therapy), and the control group was treated with Zhou’s calculi removal decoction, with a course of 1 month. The clinical efficacy and medication safety were observed, and the changes of TCM syndrome score and symptom scores were compared. Results:①Finally 150 patients completed the trial, among 75 cases in the treatment group and 75 cases in the control group. ②The total effective rates were 68.0% in the treatment group and 60.0% in the control group. The clinical efficacy of the treatment group was obviously better than that of the control group (P<0.05). ③In both groups, there were statistically significant differences on the TCM syndrome score and symptom scores between treatment before and after (P<0.05). After treatment, the TCM syndrome score in the treatment group was significantly lower than that in the control group (P<0.05). The scores of urethral burning, frequent urination and urgent urination in the treatment group were significantly lower than those in the control group (P<0.05). However, there were no statistically significant differences on the scores of lumbago, hematuresis, urination pain and lower abdominal pain between the two groups (P>0.05). Conclusion:Chinese medicine physical and breathing exercise for calculi removal combined with Zhou’s calculi removal decoction (drug-exercise combination therapy) is safe and effective in the treatment of upper urinary tract calculi with syndrome of dampness-heat diffused downward, and its efficacy is better than Chinese medicine alone, which can remarkably improve the clinical symptoms, accelerate the calculi expulsion, and relieve the pain of patients.关键词：upper urinary tract calculi;urolithiasis;syndrome of dampness-heat diffused downward;Chinese medicine physical and breathing exercise for calculi removal;Chinese medicine of calculi removal;removing urinary calculi in vitro
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发布时间：2022-08-31 - 摘要：Objective:To observe the tocolysis efficacy of prescription of nourishing kidney, activating blood and resolving phlegm in polycystic ovarian syndrome (PCOS) with threatened abortion patients with syndrome of kidney deficiency and phlegm dampness and syndrome of kidney deficiency and blood stasis. Methods 149 PCOS patients with threatened abortion were randomly divided into the group A (50 cases), group B (47 cases) and group C (52 cases). The group A was treated with prescription of nourishing kidney, activating blood and resolving phlegm. The group B was treated with progesterone injection. The group C was treated with prescription of nourishing kidney, activating blood and resolving phlegm combined with progesterone injection. All the groups were treated until pregnancy for 12 weeks, the clinical efficacy and tocolysis efficacy were observed, and the pregnancy outcome was followed up. The changes on TCM syndrome score and serum levels of human chorionic gonadotropin (HCG), progesterone (P), human insulin like growth factor binding protein-1 (IGFBP-1) and plasminogen activator inhibitor-1 (PAI-1) were compared. Results:①Finally 146 cases completed the trial, among 49 cases in the group A, 45 cases in the group B and 52 cases in the group C. ②The total effective rates were 85.71% in the group A, 64.44% in the group B and 88.46% in the group C. There was statistically significant difference on the clinical efficacy among the groups (P<0.05). There was no statistically significant difference on the clinical efficacy between group A and group C (P>0.05), however, the clinical efficacy of group A and group C was both better than that of group B (P<0.05). ③At the end of treatment, the numbers of effective tocolysis were 42 cases (85.71%) in the group A, 29 cases (64.44%) in the group B and 46 cases (88.46%) in the group C. There was no statistically significant difference on the effective rate of tocolysis between group A and group C (P>0.05), however, the effective rate of tocolysis of group A and group C was both higher than that of group B (P<0.05). ④During the trial, the abortion rates were 16.33% in the group A, 40.00% in the group B and 11.54% in the group C. There was no statistically significant difference on the abortion rate between group A and group C (P>0.05), however, the abortion rate of group A and group C was both lower than that of group B (P<0.05). ⑤After treatment, there was no statistically significant difference on TCM syndrome score between group A and group C (P>0.05), however, the TCM syndrome score of group A and group C was both lower than that of group B (P<0.05). ⑥Compared with treatment before (pregnancy for 5 weeks), the serum HCG level was significantly increased in all groups after treatment (pregnancy for 6,7, 8 and 9 weeks) (P<0.05). After treatment, compared with previous gestational week, the serum HCG level was significantly increased at different gestational weeks (P<0.05). After treatment, the serum HCG level in the group A and group C was significantly higher than that in the group B at each gestational week (P<0.05), and the serum HCG level in the group C at sixth and seventh gestational week was significantly higher than that in the group A (P<0.05). ⑦Compared with treatment before, the P level was significantly increased in the group B and group C after treatment (P<0.05); however, in the group A, there was no statistically significant difference on P level between treatment before and after(P>0.05). After treatment, there was no statistically significant difference on P level between group B and group C (P>0.05). Compared with group A, there was statistically significant difference on P level in the group B and group C, respectively (P<0.05). ⑧Compared with treatment before, the IGFBP-1 level was significantly increased (P<0.05) and the PAI-1 level was significantly decreased (P<0.05) in the group A and group C after treatment. In the group B, there were no statistically significant differences on the levels of IGFBP-1 and PAI-1 between treatment before and after (P>0.05). After treatment, there were no statistically significant differences on the increase level of IGFBP-1 and decease level of PAI-1 between group A and group C (P>0.05). Compared with group B, there were statistically significant differences on the increase level of IGFBP-1 and decease level of PAI-1 in the group A and group C, respectively (P<0.05). Conclusion:Prescription of nourishing kidney, activating blood and resolving phlegm shows better tocolysis efficacy in PCOS with threatened abortion patients with syndrome of kidney deficiency and phlegm dampness and syndrome of kidney deficiency and blood stasis, which can effectively regulate the levels of HCG, IGFBP-1 and PAI-1, improve the clinical symptoms, reduce the occurrence of spontaneous abortion and enhance the ongoing pregnancy rate and live birth rate, and thus improve the pregnancy outcome. Furthermore, for the PCOS patients with threatened abortion whose P level was lower and luteal function was insufficient, this prescription and progestin can be used simultaneously for tocolysis to achieve complementary advantages of traditional Chinese and western medicine.关键词：prescription of nourishing kidney, activating blood and resolving phlegm;polycystic ovarian syndrome;threatened abortion;tocolysis;progesterone;human insulin like growth factor binding protein-1;plasminogen activator inhibitor-1
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发布时间：2022-08-31 - 摘要：Objective:To observe the preventive and therapeutic effects of Modified Jinsu Pill on pediatric febrile convulsion (FC). Methods250 children patients with febrile convulsion were randomly divided into the treatment group (180 cases) and control group (70 cases). The control group was treated with routine western medicine in acute stage and no intervention in remission stage, the treatment group was treated with Modified Jinsu Pill two weeks after the therapy of routine western medicine in acute stage, with a treatment course of 2.5 months and follow-up of 1 year. The comprehensive efficacy was observed. The recurrence rate of febrile convulsion, the lowest temperature inducing FC and the abnormity rate of encephalogram (ECG) were compared. Results:①Finally 228 cases completed the trial, among 165 cases in the treatment group and 63 cases in the control group. ②The effective rates were 69.7% in the treatment group and 54.0% in the control group. The comprehensive efficacy of the treatment group was better than that of the control group, with statistically significant difference (P<0.05). ③The recurrence rate of convulsion in the treatment group was obviously lower than that in the control group, with statistically significant difference (P<0.05). ④Among the patients with recurrence convulsion, compared between treatment before and follow-up, there was statistically significant difference on the lowest temperature inducing FC in both groups, and the temperature was obviously increased in both groups (P<0.05). However, during the follow-up, there was no statistically significant difference on the lowest temperature inducing FC between the two groups (P>0.05). ⑤After follow-up for one year, the abnormity rates of ECG were 9.5% in the treatment group and 21.3% in the control group, the abnormity rate of ECG of the treatment group was obviously lower than that of the control group, with statistically significant difference (P<0.05). Conclusion:Modified Jinsu Pill exerts certain preventive effects on the recurrence of pediatric febrile convulsion, as well as the brain damage induced by febrile convulsion.关键词：febrile convulsion;pediatric;Modified Jinsu Pill;recurrence rate;lowest temperature inducing febrile convulsion;encephalogram;epilepsy
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发布时间：2022-08-31 - 摘要：Objective:To observe the clinical efficacy of TCM cognitive therapy combined with Modified Banxia Houpo Decoction in treating laryngopharyngeal reflux diseases with syndrome of qi stagnation and phlegm coagulation. Methods70 patients of laryngopharyngeal reflux diseases with syndrome of qi stagnation and phlegm coagulation were randomly divided into the control group and the treatment group, 35 cases in each group. The control group was treated with Modified Banxia Houpo Decoction, and the treatment group was treated with TCM cognitive therapy based on the treatment for the control group, with a course of 2 months. The clinical efficacy was observed. The changes of reflux symptom index (RSI), reflux finding score (RFS) and modified Morisky questionnaire were compared. Results:①=1\*GB3The total effective rates were 88.6% in the treatment group and 77.1% in the control group, respectively. The clinical efficacy of the treatment group was better than that of the control group (P<0.05). ②=2\*GB3Compared with treatment before, all item scores and the total score of RSI in both groups were decreased after treatment (P<0.05). After treatment, the scores of irritable cough, dyspnea, supine cough, difficulty in swallow and spit, clearing throat, something sticky and stagnant in throat and the total score in the treatment group were lower than those in the control group (P<0.05). ③=3\*GB3Compared with treatment before, all item scores and the total score of RFS in both groups were decreased after treatment (P<0.05). After treatment, the scores of false vocal ditch, granuloma, diffuse laryngeal edema, throat chamber disappear, polypoid changes, subglottic edema and the total score in the treatment group were lower than those in the control group (P<0.05). ④=4\*GB3After treatment, the score of modified Morisky questionnaire in the treatment group was lower than that in the control group (P<0.05). Conclusion:TCM cognitive therapy combined with Modified Banxia Houpo Decoction shows satisfactory efficacy in the treatment of laryngopharyngeal reflux diseases with syndrome of qi stagnation and phlegm coagulation, which can remarkably ameliorate the reflux symptoms and signs, and improve the compliance of patients.关键词：laryngopharyngeal reflux disease;qi stagnation and phlegm coagulation;TCM cognitive therapy;Banxia Houpo Decoction
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发布时间：2022-08-31 - 摘要：Objective:To observe the clinical efficacy of Jinbai Mixture in treating acute viral cough in children. Methods270 children patients with acute viral cough who met the observation standard were randomly divided into Jinbai Mixture group, Qingre Zhike group anjing (ambroxol hydrochloride and clenbuterol hydrochloride oral solution) group, who were treated with Jinbai Mixture,Qingre Zhike Oral Solution and Yitanjing respectively, with a course of 5 days. The quantitative indexes of symptom grading in children were observed and the clinical efficacy was evaluated, the changes on TCM syndrome score were observed before and after treatment,and the adverse medical events occurred in the treatment were recorded. Results:Before treatment,there were no statistical differences in gender, age and course of disease among groups.The total clinical effective rates were 87.78% in the Jinbai Mixture group, 72.22% in the Qingre Zhike group and 52.87% in the Yitanjing group,respectively. The clinical control rate of the Jinbai Mixture group was obviously better than that of the Qingre Zhike group and Yitanjing group(P<0.01). The scores of TCM syndromes in all groups were decreased after treatment (P<0.01). The D-value of total score of TCM syndrome between treatment before and after in the Jinbai Mixture group was significantly higher than that in the Qingre Zhike group(P<0.05) andYitajing group(P<0.01), and the D-value of cough score and expectoration score in the Jinbai Mixture group were greater than those in the Qingre Zhike group andYitajing group(P<0.01). No adverse reactions were found in all groups. Conclusion:Jinbai Mixture can significantly improve the clinical symptoms of cough and excessive phlegm in children with acute upper respiratory tract infection, and the clinical control rate is significant.关键词：Jinbai Mixture;acute viral cough in children;TCM syndromes;clinical efficacy
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发布时间：2022-08-31 - 关键词：disease-syndrome combination;urinary tract infection;traditional Chinese medicine treatment
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发布时间：2022-08-31 - 摘要：Objective:To observe the mechanisms of Kangxianling Decoction on renal fibrosis in rats with adriamycin nephropathy. MethodsSD male rats were randomly divided into 7 groups, 8 rats in each group. The normal group was treated with no surgery, and the sham operation group was treated with 0.9% NaCl solution after right nephrectomy. The other 40 SD rats were treated with right nephrectomy and intravenous injection of adriamycin to establish the adriamycin nephropathy model. After successful modeling, the model rats were randomly divided into the model group, Cozaar group, Kangxianling Decoction groups with low-, medium- and high-dose. The rats were treated with the corresponding drugs for 8 weeks. The serum creatinine, urea nitrogen, 24 h urinary protein excretion, mRNA expressions of α-smooth muscle actin (α-SMA) and fibronectin (FN) in kidney tissue were detected, and the renal pathology was observed after HE staining. Results:Compared with the model group, the α-SMA expression and the FN level were significantly decreased in Kangxianling Decoction group, with statistically significant differences (P<0.05). Meanwhile, the levels of 24 h urinary protein excretion, serum creatinine and urea nitrogen were decreased after Kangxianling Decoction treatment, the renal function was improved and the development of renal fibrosis was delayed, with statistically significant differences (P<0.05). The anti-fibrosis effects of Kangxianling Decoction was enhanced with the increase of dosage, with statistically significant differences (P<0.05). Conclusion:Kangxianling Decoction can decrease 24 h urinary protein excretion, improve the renal function and pathological histomorphology in a dose-dependent manner. Its mechanism on improving renal fibrosis may be down-regulating the expression of α-SMA and inhibiting the production of FN.关键词：Kangxianling Decoction;renal fibrosis;adriamycin nephropathy;rat
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发布时间：2022-08-31 - 摘要：Objective:Taken 16HBE human bronchial epithelial cell line as the research object, the effects of Qixian Decoction extract on inhibiting airway epithelial-mesenchymal transition(EMT)in asthma are investigated in vitro. MethodsThe 16HBE cells were intervened by H2O2 and Qixian Decoction extract at different concentrations for different time to observe the cell morphology changes. CCK-8 assay was used to detect the effect of H2O2 on the viability of 16HBE cells. RT-PCR was used to detect the gene expression levels of E-cadherin and α-SMA. The protein expression levels of E-cadherin and α-SMA were detected by Western blot. The protein expression levels and protein localization of E-cadherin and α-SMA were detected by immunofluorescence. Results:The morphology of cells showed the changes of EMT after H2O2 treatment, and the extract of Qixian Decoction reversed the EMT changes. The results of CCK-8 assay showed that the survival rate of airway epithelial cells was decreased with the increasing concentration of H2O2 (P<0.01). The extract of Qixian Decoction reduced the damage of airway epithelial cells induced by H2O2 (P<0.01). The results of RT-PCR showed that the level of E-cadherin mRNA in airway epithelial cells was significantly decreased after H2O2 stimulation (P<0.01), and the level of α-SMA mRNA was increased (P<0.05). The extract of Qixian Decoction reversed the decreased level of E-cadherin transcription induced by H2O2 (P<0.05), as well as the increased expression of α-SMA mRNA induced by H2O2 (P<0.05). The results of Western blot and immunofluorescence showed that the protein expression levels of E-cadherin and α-SMA were consistent with the gene expression levels (P<0.05). Conclusion:Qixian Decoction can reduce the airway epithelial cell damage and airway epithelial-mesenchymal transition induced by oxidative stress.关键词：Qixian Decoction;airway epithelial-mesenchymal transition;oxidative stress
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发布时间：2022-08-31 - 摘要：Objective:To observe the effects of Gutongling Prescription on the Blimp1/Bcl6 pathway in the mouse pain model of bone metastasis of lung cancer. Methods85 C57BL/6 mice were selected. Among, 17 mice were taken as the sham operation group, which treated with PBS solution. The pain model of bone metastasis of lung cancer was established in the other 68 mice by injecting Lewis cells suspension into the left hind tibia medullary cavity. Then the model mice were randomly divided into the model group, Chinese medicine group, western medicine group, Chinese and western medicine combination group, 17 mice in each group. The Chinese medicine group was treated with decoction of Gutongling Prescription by intragastric administration, the western medicine group was treated with zoledronic acid by intraperitoneal injection, and the Chinese and western medicine combination group was treated with decoction of Gutongling Prescription and zoledronic acid, with a course of 3 weeks. The osteoclasts of tibia in mice were detected by TRAP staining. The mRNA and protein expressions of B lymphocyte induced maturation protein1(Blimp1), B-cell lymphoma 6(Bcl6) and cathepsin K(Ctsk) were detected by RT-PCR and Western Blot. Results:Compared with the model group, the number of TRAP positive cells was decreased remarkably in the Chinese medicine group, western medicine group and Chinese and western medicine combination group, and the mRNA and protein expressions of Blimp1 and Ctsk were reduced, while the mRNA and protein expressions of Bcl6 were increased, with statistically significant differences (P<0.05). Among the three drug treatment groups, the Chinese and western medicine combination group showed the least number of positive cells, the lowest mRNA and protein expressions of Blimp1 and Ctsk and the highest mRNA and protein expressions of Bcl6, with statistically significant differences (P<0.05). Conclusion:Gutongling Prescription can suppress the osteoclast activation by inhibiting Blimp1/Bcl6 pathway, and thus alleviate the pain induced by bone metastasis of lung cancer.关键词：bone metastasis of lung cancer;osteoclast;Blimp1;Bcl6;Ctsk
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发布时间：2022-08-31 - 摘要：Objective:To explore the renal protective effects of panaxadiol saponin (PDS) in mice with endotoxemia, and reveal the relationship between protective effects and expressions of inflammation factors, urea transporter A2 (UT-A2) and urea transporter A3 (UT-A3). MethodsThe model of endotoxemia was established in C57BL/6 mice, and the mice were divided into the control group, LPS group, PDS+LPS group and Dexa+LPS group. The heart rate and average arterial pressure were recorded under anesthesia. The body weight and kidney weight were recorded to calculate the coefficient. The kidney tissue was fixed and cryopreserved for HE staining and immunohistochemistry. Results:Compared with the control group, the heart rate and the average arterial pressure were decreased in the LPS group (P<0.05), the levels of TNF-α and IL-6 were significantly increased (P<0.01), the protein expression levels of UT-A2 and UT-A3 in the kidney tissue were decreased significantly, and the renal pathological inflammation and the renal interstitial cell edema were observed. Compared with the model group, the heart rate and the average arterial pressure were restored in both PDS+LPS group and Dexa+LPS group (P<0.05), the levels of TNF-α and IL-6 were significantly decreased (P<0.05), and the protein expressions of UT-A2 and UT-A3 in the kidney tissue were increased, the renal pathological inflammation and the interstitial cell edema were alleviated. Conclusion:Panaxadiol saponin can decrease the proinflammatory factor TNF-α and IL-6 levels, increase the protein expressions of UT-A2 and UT-A3 in kidney tissue, improve the renal pathological inflammation and alleviate the renal interstitial cells swelling state in endotoxemia mice, and thus effectively prevent and protect from the renal injury induced by endotoxemia, which is similar to dexamethasone.关键词：panoxadiol saponin;dexamethasone;urea transporter;Endotoxin
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发布时间：2022-08-31 - 摘要：Objective:To observe the effects of Tongjiang Mixture on rat model of simple gastroesophageal reflux and the influence on brain-gut axis. MethodsThe rat model of simple gastroesophageal reflux was established by surgery in healthy male SD rats. 30 successfully modeling rats were randomly divided into the model group and Tongjiang Mixture groups with low- and high-dose, 10 rats in each group. 10 healthy male SD rats were taken as the control group. The control group was only treated with suture after opening abdominal cavity. The Tongjiang Mixture groups with low- and high-dose were treated with Tongjiang Mixture at dose of 10 ml/kg and 20 ml/kg by intragastric administration, and the control group and model group were treated with 0.9% NaCl solution at dose of 20 ml/kg, with a course of 4 continuous weeks. The electrogastrogram (EGG) was observed. The pH value of mucous membrane of lower esophagus and gastric juice and the level of pepsin in gastric juice were detected. The levels of gastrointestinal active substances in rat plasma and gastric antrum tissue were measured by ELISA. The levels of neurotransmitter in rat plasma were detected by HPLC. The esophagus was isolated for esophagitis evaluation. Results:①Compared with the control group, the frequency and amplitude of EGG, the pH value of mucous membrane of lower esophagus, the gastrin level in plasma and the levels of gastrointestinal active substances (gastrin, motilin and substance P) in gastric antrum tissue were decreased in the model group (P<0.05), the levels of pepsin in gastric juice and neurotransmitter (norepinephrine, 5-hydroxytryptamine and dopamine) in plasma and the esophagitis score were increased (P<0.05). ②Compared with the model group, the frequency and amplitude of EGG in the Tongjiang Mixture groups with low- and high-dose were increased (P<0.05), and the pH value of mucous membrane of lower esophagus was increased (P<0.05). ③Compared with the model group, the gastrin levels in rat plasma and gastric antrum tissue were increased in the Tongjiang Mixture groups with low- and high-dose (P<0.05), and the plasma levels of norepinephrine and dopamine were decreased in the Tongjiang Mixture group with high-dose (P<0.05). ④Compared with the model group, the esophagitis score of rats in the Tongjiang Mixture groups with low- and high-dose was reduced (P<0.05). Conclusion:Tongjiang Mixture can obviously improve the gastrointestinal motility and inhibit the regurgitation injury in rat model of simple gastroesophageal reflux, and regulate the brain-gut axis related peripheral neurotransmitters and gastrointestinal active substances.关键词：gastroesophageal reflux;rat;Tongjiang Mixture;brain-gut axis;norepinephrine;dopamine;gastrin
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发布时间：2022-08-31 - 摘要：Objective:To investigate the influence of different alkaline hydrolysis conditions on the contents of 4 rare ginsenosides including 20(S)-Rh1, 20(S)-Rh2, 20(S)-PPt, and 20(S)-PPd. MethodsHigh performance liquid chromatography-mass spectrometry (HPLC-MS) was applied to preliminarily infer the ginsenoside structure generated by alkaline hydrolysis of total saponin of ginseng stem and leaf. HPLC was adopted to determine the influence of different alkaline hydrolysis conditions, including reaction time, reaction temperature, amount of sodium hydroxide (NaOH), on the contents of ginsenosides 20(S)-Rh1, 20(S)-Rh2, 20(S)-PPt and 20(S)-PPd. Results:To obtain the high yield of ginsenoside 20(S)-Rh1 and 20(S)-Rh2, the condition was suggested as alkaline hydrolysis for 40 minutes, reaction temperature at 200 and 220 ℃ respectively and adding 2.0 g NaOH. To obtain the high yield of ginsenoside 20(S)-PPt and 20(S)-PPd, the condition was suggested as alkaline hydrolysis for 6 hours, reaction temperature at 240 ℃ and adding 2.0 g NaOH. Conclusion:The influence trend of reaction temperature in alkaline hydrolysis and amount of NaOH on the contents of ginsenoside 20(S)-Rh1, 20(S)-Rh2, 20(S)-PPt and 20(S)-PPd was similar, while the influence trend of reaction time was different.关键词：rare ginsenoside;alkaline hydrolysis;ginsenoside 20(S)-Rh;1;2;ginsenoside 20(S)-PPt;ginsenoside 20(S)-PPd
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发布时间：2022-08-31 - 摘要：This paper reviews the research progress of molecular neurobiological mechanisms of traditional Chinese medicine in the treatment of vascular cognitive impairment. In recent years,more and more traditional Chinese medicine related researches expound the mechanisms of this disease and the targets of Chinese medicine through the molecular biology and pathways,such as impact on the signal transduction pathways, inhibition on cell apoptosis, regulation on central neurotransmitter, intervention on synaptic plasticity changes,which thus plays the therapeutic role on cognitive impairment.关键词：vascular cognitive impairment;therapy of traditional Chinese medicine;molecular neurobiology;review
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发布时间：2022-08-31 - 摘要：By searching for the literatures on neuropharmacology of ginsenosides Rg2 and Rh1, the related pharmacological effects and mechanisms of ginsenosides Rg2 and Rh1 are reviewed. Modern pharmacological studies have found that ginsenosides Rg2 and Rh1 show strong pharmacological activity in nervous system,which can protect nerve cells, anti cerebral ischemia-reperfusion injury, treat Alzheimer’s disease and vascular dementia, anti-depression and so on.关键词：ginsenoside Rg;2;ginsenoside Rh;1;nervous system;pharmacological effects;mechanism;review
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发布时间：2022-08-31
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