最新刊期
期 10 ， 2018
- 摘要：This paper introduces the ten methods of Cui Yuheng,a national famous veteran doctors of traditional Chinese medicine,in treating cough. It is considered that the etiology and pathogenesis of cough are complex. It is necessary to make the detail differentiation between external and internal factors,cold and heat,deficiency and excess,and then different treatment methods are performed. The commonly used methods in clinic include therapy of dispelling cold and resolving fluid retention,therapy of clearing heat and eliminating phlegm,therapy of dispelling wind for desensitization,therapy of alleviating arthralgia and relieving cough,therapy of relieving Shaoyang disorder and clearing heat,therapy of replenishing lung and benifiting qi,therapy of invigorating spleen and eliminating phlegm,therapy of tonifying kidney and relieving cough,therapy of nourishing lung and kidney and therapy of resolving food stagnation. One proven case is presented.关键词：cough;therapy of traditional Chinese medicine;experience of famous doctor;Cui Yuheng
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发布时间：2022-08-31 - 摘要：This paper discusses from textual research, annotation and clinical practice of Shanghan Lun(Treatise on Cold Pathogenic Diseases). The study of Shanghan Lun focuses on textual criticism before Song Dynasty and original annotation after Song Dynasty. The former seeks the original appearance and the latter elucidates the medical theory. The close connection between Shanghan Lun and clinical practice is the basis of the study. It should pay attention to the specific treatment methods and prescriptions,meanwhile,it also should fully understand the principles and rules of syndrome treatment in Shanghan Lun,as well as the pattern and system of clinical diagnosis and treatment.关键词：Shanghan Lun(Treatise on Cold Pathogenic Diseases);textual research;annotation;clinical practice
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发布时间：2022-08-31 - 摘要：The discussions on perinatal depression in obstetrics and gynecology of TCM are scattered in pregnancy and postpartum diseases due to depression syndrome. All the physical discomfort caused or aggravated by internal injuries by excess of seven emotions, or induced by spirit weakness and evil, or accompanied with depressive disorder and mental behavior disorder manifestations, all of which belongs to the category of pregnancy and postpartum diseases due to depression syndrome. The pathogenesis includes qi, blood, phlegm and blood stasis, involving heart, liver, spleen, kidney and other organs. Clearing this disease can not only help to determine the strategy and prescription medication based on relieving depression, more importantly, but also promote to establish the concept of preventive treatment of disease.关键词：pregnancy disease due to depression syndrome;postpartum disease due to depression syndrome;dizziness of woman after delivery;perinatal depression;treatment based on relieving depression
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发布时间：2022-08-31 - 摘要：Objective:To systematically evaluate the effects of elemene on quality of life in patients with advanced cancer. MethodsThe databases including China national knowledge infrastructure (CNKI), Wanfang, VIP Chinese periodical full-text and web of science were used to retrieve the randomized controlled trials (RCTs) involving chemotherapy combined with elemene treatment group (treatment group) and chemotherapy alone group (control group) in the treatment of advanced cancer. Data extraction and quality evaluation were conducted for the included documents. Meta-analysis was performed by RevMan 5.3 software. The efficacy and safety on improving the quality of life of patients in both groups were compared. Results:①A total of 20 RCTs were included. ②The stability rate of quality of life [OR=2.87,5% CI (2.28,3.61), P<0.000 1] and the improvement rate of quality of life [OR=2.89,5% CI (2.32,3.75), P<0.000 1] of patients in the treatment group were significantly higher than those in the control group. ③The incidence rate of leukocyte inhibition [OR=0.40,5% CI (0.29,0.55), P <0.000 1], the incidence rate of platelet inhibition [OR=0.50,5% CI (0.36,0.69), P<0.000 1] and the incidence rate of gastrointestinal reactions [OR=0.64,5% CI (0.49,0.84), P =0.001] in the treatment group were lower than those in the control group. However, the incidence rate of fever [OR=2.90, 95% CI (1.62,5.22), P =0.000 4] in the treatment group was higher than that in the control group. There were no statistically significant differences on the incidence rate of liver function damage [OR=0.72,5% CI (0.45,1.15), P=0.17], the incidence rate of kidney function damage [OR=0.48,5% CI (0.16, 1.45), P=0.19] and the incidence rate of phlebitis [OR=2.45,5% CI (0.62,9.63), P=0.20] between the two groups. Conclusion:Compared with chemotherapy alone, chemotherapy combined with elemene can not only significantly improve the quality of life of patients with advanced cancer, but also reduce the myelosuppression and gastrointestinal adverse reactions. However, the application of elemene increases the risk of fever in patients, so the specific clinical application should be applied according to the specific circumstances of patients.关键词：advanced cancer;elemene;quality of life;systematical evaluation;Meta-analysis
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发布时间：2022-08-31 - 摘要：This paper discusses Professor Zheng Pingdong’s clinical experience in treating nephrotic syndrome. It is considered that the therapy of this disease should be focused on treating lung and eliminating pathogenic factors in the early stage and regulating and tonifying spleen and kidney in the later period. Taken the zang-fu viscera as the outline,the treatment reactions of lung,spleen and kidney are quick,slow and delayed respectively. The treatment should be relieving swelling first and taking excess elimination as core,which is guided in the light of its general trend. The location of water retention and the channel tropism of medicines are emphasized. After edema is recovered,invigorating spleen and tonifying kidney should be strengthened. For the side effects caused by hormone,therapies of regulating kidney qi,regulating qi and blood and clearing toxic heat are applied. One proven case is presented.关键词：nephrotic syndrome;edema;quick,slow and delayed treatment reaction for lung,spleen and kidney respective;eliminating pathogenic factor;invigorating spleen and tonifying kidney
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发布时间：2022-08-31 - 关键词：fever;benefiting qi and nourishing yin;experience of physician;He Liren
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发布时间：2022-08-31 - 摘要：This paper discusses the prescription-syndrome and application rules of Zhizichi Decoction based on the opinions of different physicians and the comments in past dynasties. It is considered that this prescription is not simply aimed at psychosomatic disease,but more applied for the diseases with root cause in stomach,that is diseases caused by attacking induced stomach injury,damage of stomach fluid,stagnated heat disturbing stomach as well as chest and diaphragm. And its clinical application is developed.关键词：spleen and stomach diseases;damage of stomach fluid;Zhizichi Decoction
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发布时间：2022-08-31 - 摘要：This paper analyzes the couplet medicines application in Ding Ganren’s damp-warm syndrome medical records as well as the experience in syndrome differentiation, treatment and prescription medication. In Ding’s treatment on damp-warm syndrome, the commonly used couplet medicines are Fuling-Banxia, Fuling-Zexie, Fuling-Peilan and so on. According to the pathogenesis of Sanjiao, products with effects of eliminating dampness, regulating qi-flowing and warming interior are reasonably combined. The classical prescriptions with modification are made good use. The retrograde treatment is made good use. The medication is focused on slight and flexible.关键词：Ding ganren;medical records;damp-warm syndrome;couplet medicines;characteristics of syndrome differentiation and treatment
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发布时间：2022-08-31 - 摘要：By sorting out the literatures and reviewing the medical records in Wang Renzhi’s Medical Records,this paper summarizes Wang Renzhi’s experience in treating abdominal pain during menstruation. It is considered that pathogenesis is the stagnation and malnutrition of qi and blood which may bring about pain. The treatment methods are removing blood stasis and warming yang which emphasizes treating both manifestation and root cause of disease,harmonizing qi and blood combined with nourishing yin；co-regulating liver and kidney which aims to consolidate body resistance and culture promordial qi. Three proven cases are presented.关键词：abdominal pain during menstruation;experience of famous doctors;Wang Renzhi
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发布时间：2022-08-31 - 摘要：The mechanism and causes of “Wei qi internal invading” are analyzed from the ascending and descending, exiting and entering of Wei qi. According to the physiological and pathological characteristics of Wei qi, it is concluded that the ascending and descending, exiting and entering channel of Wei qi movement is the “lower jiao- middle jiao- upper jiao- lung governing diffusion- muscle- body surface”. This channel dysfunction can lead to the “Wei qi internal invading”, with the clinical symptoms of fever, fullness and skin insensitivity. The treatment is mainly to dredge the channel of qi movement. One proven case is presented.关键词：Huangdi Neijing (Inner Canon of Huangdi);Wei qi;Wei qi internal invading;channel of qi movement;ascending and descending;exiting and entering;proven case
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发布时间：2022-08-31 - 摘要：Objective:To observe the clinical efficacy of Xu’s Danmajia Formula in treating chronic obstructive pulmonary disease (COPD) with syndrome of turbid phlegm obstructing lung. Methods106 COPD patients with syndrome of turbid phlegm obstructing lung were randomly divided into the treatment group and control group, 53 cases in each group. The treatment group was treated with Xu’s Danmajia Formula, while the control group was treated with Guilong Kechuanning Capsule, with a course of 10 days. The clinical efficacy and safety and the acute exacerbation within 3 months of follow-up were observed. The changes on TCM syndrome score, CAT score, percentage of forced expiratory volume in the first second to the predicted value (FEV1%), and percentage of forced expiratory volume in the first second to the forced vital capacity (FEV1/FVC) were compared. Results:①Finally 96 patients completed the trial, among 50 cases in the treatment group and 46 cases in the control group. ②The total effective rates were 98.0% in the treatment group and 63.0% in the control group, the clinical efficacy of the treatment group was significantly better than that of the control group (P<0.05). ③Compared with treatment before, the level of FEV1% in the treatment group showed an increasing tendency after treatment, but with no statistically significant difference (P>0.05). And in the treatment group, there was no statistically significant difference on FEV1/FVC level between treatment before and after (P>0.05). In the control group, there were no statistically significant differences on the levels of FEV1% and FEV1/FVC between treatment before and after (P>0.05). After treatment, there were no statistically significant differences on the levels of FEV1% and FEV1/FVC between the two groups (P>0.05). ④No drug-related adverse reactions were observed in both groups during the trial, and no abnormality in routine safety examination was observed before and after treatment. During the follow-up, no acute exacerbation of chronic obstructive pulmonary disease occurred in the treatment group, and 2 patients in the control group showed asthma exacerbation and were alleviated after treatment with bronchodilators and hormones. Conclusion:Xu’s Danmajia Formula in treating chronic obstructive pulmonary disease with syndrome of turbid phlegm obstructing lung shows satisfactory clinical efficacy, which can significantly relieve the clinical symptoms and improve the quality of life of patients.关键词：chronic obstructive pulmonary disease;syndrome of turbid phlegm obstructing lung;Danmajia Formula;Xu Zhongcai;Lu Hongyuan
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发布时间：2022-08-31 - 摘要：Objective:To observe the preventive effects of Tongyu Decoction on cardiovascular events after castration of prostate cancer. Methods110 patients with prostate cancer were randomly divided into the treatment group and control group, 55 cases in each group. The control group was treated with castration therapy, and the treatment group was treated with Tongyu Decoction based on the treatment for the control group, with a treatment course of 3 months and follow-up of 6 months. The occurrences of cardiovascular events and end events were observed. The changes of cardiovascular events related indicators including fasting insulin (FINS), fasting blood glucose (FBG), carotid artery intima-media thickness (IMT) and high sensitivity C-reactive protein (hs-CRP) were compared. Results:①During the research, the cardiovascular events occurred in 14 patients in the control group, including 1 case of cerebral infarction, 2 cases of cerebral hemorrhage, 9 cases of intracranial lacunar lesions, 1 case of myocardial infarction and 1 case of angina (among 1 case of cerebral hemorrhage and 1 case of myocardial infarction were dead), the incidence rate was 25.45%. The cardiovascular events occurred in 4 patients in the treatment group, all of them were observed intracranial lacunar lesions and no one died, the incidence rate was 7.27%. There was statistically significant difference on the incidence rate of cardiovascular events between the two groups, and the incidence rate in the treatment group was obviously lower than that in the control group (P<0.05). ②Compared with treatment before, the levels of IMT, hs-CRP and IRI were decreased in the treatment group after treatment, with statistically significant differences (P<0.05), while the levels of IMT and hs-CRP were increased in the control group after treatment, with statistically significant differences. After treatment, there were statistically significant differences on the levels of IMT, hs-CRP and IRI between the two groups, and the improvement on these indicators in the treatment group was better than that in the control group (P<0.05). Conclusion:Tongyu Decoction can significantly reduce the incidence of cardiovascular events after castration of prostate cancer, and play the synergistic effects with castration therapy for prostate cancer. Its mechanism may be related to decreasing insulin resistance and inhibiting hs-CRP.关键词：prostate cancer;castration therapy;cardiovascular event;Tongyu Decoction;insulin resistance;inflammatory reaction
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发布时间：2022-08-31 - 摘要：Objective:To observe the clinical efficacy of Jianpi Jiedu Decoction in preventing and treating chemotherapy-related peripheral neuropathy in postoperative patients with colorectal cancer. Methods64 postoperative patients of colorectal cancer were randomly divided into the control group and treatment group, 32 cases in each group. The control group was treated with XELOX chemotherapy regimen, and the treatment group was treated with Jianpi Jiedu Decoction based on the treatment for the control group, with a course of 8 cycles of chemotherapy. The cycle of chemotherapy completion, the cycle of first-time occurrence of chronic and cumulative chemotherapy-induced peripheral neuropathy (CIPN) symptoms, completion rate of planned therapeutic dose of oxaliplatin and frequency of 3-4 degree myelosuppression were observed. The changes of NCI-CTCAE grades, FACT/GOG-Ntx score, PNQ grades and serum IL-1β level were compared. Results:①Finally 60 patients completed the trial, among 31 cases in the treatment group and 29 cases in the control group. ②There was no statistically significant difference on chemotherapy completion cycle between the two groups (P>0.05). There was statistically significant difference on completion rate of planned therapeutic dose of oxaliplatin between the two groups, and the completion rate of planned therapeutic dose of oxaliplatin in the treatment group was significantly higher than that in the control group (P<0.05). There was statistically significant difference on the cycle of first-time occurrence of cumulative CIPN symptoms between the two groups, and the first-time occurrence of cumulative CIPN symptoms of the treatment group was obviously later than that of the control group (P<0.05). There was no statistically significant difference on frequency of degree 3-4 myelosuppression between the two groups (P>0.05). ③Compared between during chemotherapy and after chemotherapy, there were statistically significant differences on NCI-CTCAE grades and FACT/GOG-Ntx score in both groups (P<0.05). During the chemotherapy, there were statistically significant differences on NCI-CTCAE grades and FACT/GOG-Ntx score between the two groups, and the NCI-CTCAE grades and FACT/GOG-Ntx score in the treatment group were obviously lower than those in the control group (P<0.05). After chemotherapy, there were statistically significant differences on NCI-CTCAE grades and FACT/GOG-Ntx score between the two groups, and the NCI-CTCAE grades and FACT/GOG-Ntx score in the treatment group were obviously lower than those in the control group (P<0.05). ④Compared between during chemotherapy and after chemotherapy, there were statistically significant differences on PNQ1 grades in both groups (P<0.05), while there were no statistically significant differences on PNQ2 grades in both groups (P>0.05). During the chemotherapy, there were statistically significant differences on PNQ1 grades and PNQ2 grades between the two groups, and the grades in the treatment group were obviously lower than those in the control group (P<0.05). After chemotherapy, there were statistically significant differences on PNQ1 grades and PNQ2 grades between the two groups, and the grades in the treatment group were obviously lower than those in the control group (P<0.05). ⑤Compared with chemotherapy before, at the half course of chemotherapy and after chemotherapy, there was statistically significant difference on IL-1β level in both groups (P<0.05), the IL-1β level was obviously decreased in the treatment group, while the IL-1β level was obviously increased in the control group (P<0.05). At the half course of chemotherapy, there was statistically significant difference on IL-1β level between the two groups, and the IL-1β level in the treatment group was significantly lower than that in the control group (P<0.05). After chemotherapy, there was statistically significant difference on IL-1β level between the two groups, and the IL-1β level in the treatment group was significantly lower than that in the control group (P<0.05). Conclusion:Jianpi Jiedu Decoction can obviously alleviate the chemotherapy-induced peripheral neuropathy after the operation of colorectal cancer, enhance the compliance and tolerance of patients to chemotherapy, maximize the benefits of chemotherapy, and thus improve the quality of life of patients.关键词：colorectal cancer;postoperative chemotherapy;chemotherapy-related peripheral neuropathy;Jianpi Jiedu Decoction;reducing toxicity and enhancing efficac
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发布时间：2022-08-31 - 摘要：Objective:To observe the clinical efficacy of Jianpi Huashi Jiedu Decoction combined with recombinant human interferon α-2b gel in the treatment of chronic cervicitis complicated with high risk human papillomavirus (HPV) infection. Methods188 patients of chronic cervicitis with high risk HPV infection were randomly divided into the treatment group and control group, 94 cases in each group. The control group was treated with recombinant human interferon α-2b gel, and the treatment group was additionally treated with Jianpi Huashi Jiedu Decoction based on the treatment for the control group, with a treatment course of 2 months and follow-up of 6 months. The negative conversion rate and recurrence rate of HPV and adverse reactions were observed. The changes on HPV viral load, clinical symptoms and signs of patients were compared. Results:①In both groups, there was statistically significant difference on the HPV viral load between treatment before and after, and the HPV viral load was obviously decreased in both groups after treatment (P<0.05). After treatment, the HPV viral load in the treatment group was obviously lower than that in the control group (P<0.05). There was statistically significant difference on the HPV negative conversion rate between the two groups, and the HPV negative conversion rate in the treatment group was obviously higher than that in the control group (P<0.05). ②In both groups, there were statistically significant differences on the occurrence rates of lumbosacral pain, leucorrhea with large amount, contact bleeding and purulent secretion between treatment before and after, and the occurrence rates were decreased in both groups after treatment (P<0.05). After treatment, the occurrence rates of lumbosacral pain, leucorrhea with large amount, contact bleeding and purulent secretion in the treatment group were obviously lower than those in the control group (P<0.05). ③There was statistically significant difference on the recurrence rate between the two groups, and the recurrence rate in the treatment group was obviously lower than that in the control group (P<0.05). ④There was no statistically significant difference on the incidence rate of adverse reactions between the two groups (P>0.05). Conclusion:Jianpi Huashi Jiedu Decoction combined with recombinant human interferon α-2b gel in the treatment of chronic cervicitis with high risk HPV infection can obviously increase the HPV negative conversion rate, reduce the recurrence rate and improve the clinical symptoms and signs, with fewer adverse reactions.关键词：chronic cervicitis;human papillomavirus (HPV);interferon;therapy of invigorating spleen and eliminating dampness and detoxification;negative conversion rate
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发布时间：2022-08-31 - 摘要：Objective:To observe the clinical efficacy of Xuanfei Qingying Formula combined with routine therapy of western medicine in the treatment of acute mycoplasma pneumoniae pneumonia in children. Methods62 children patients with mycoplasma pneumoniae pneumonia were randomly divided into the treatment group (32 cases) and control group (30 cases). The control group was treated with routine therapy of western medicine, and the treatment group was treated with Xuanfei Qingying Formula based on the treatment for control group, with a treatment course of 7 days and follow-up of 10 days. The clinical efficacy was observed, the time of lesion complete absorption that displayed in chest X-ray, the defervescence time, the disappearance time of cough, moist rales and wheezing rales were compared. Results:①The total effective rates were 96.9% in the treatment group and 80.0% in the control group respectively, and the clinical efficacy of the treatment group was obviously better than that of the control group (P<0.05). ②During the trial, the time of lesion complete absorption, the defervescence time, the disappearance time of cough, moist rales and wheezing rales in the treatment group were all significantly shorter than those in the control group (P<0.05). Conclusion:Xuanfei Qingying Formula combined with routine therapy of western medicine in the treatment of acute mycoplasma pneumoniae pneumonia in children can significantly enhance the efficacy, alleviate the clinical symptoms and signs and shorten the course of illness.关键词：mycoplasma pneumoniae;pediatric pneumonia;Xuanfei Qingying Formula;azithromycin;integrated traditional Chinese and western medicine
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发布时间：2022-08-31 - 摘要：Objective:To observe the clinical efficacy of tuina under the guidance of concept of holism in the treatment of knee osteoarthritis. Methods74 patients were randomly divided into the control group and treatment group, 37 cases in each group. The control group was orally treated with celecoxib, and the treatment group was treated with tuina under the guidance of concept of holism, with a course of 3 weeks. The clinical efficacy was observed, and the changes on WOMAC scores were compared. Results:①Finally 73 cases completed the trial, among 36 cases in the treatment group and 37 cases in the control group. ②The total effective rates were 94.4% in the treatment group and 81.1% in the control group, the clinical efficacy of the treatment group was obviously better than that of the control group (P<0.05). ③In both groups, there were statistically significant differences on all item scores and total score of WOMAC between treatment before and after (P<0.05). After treatment, all item scores and total score of WOMAC in the treatment group were obviously lower than those in the control group (P<0.05). Conclusion:The application of Tuina under the guidance of concept of holism in treating knee osteoarthritis can remarkably ameliorate the pain of joint, improve the degree of stiffness and capacity of action in patients, and thus enhance the quality of life of patients.关键词：knee osteoarthritis;concept of holism;Tuina;external treatment of Chinese medicine;spine-pelvis-sagittal plane of lower limb
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发布时间：2022-08-31 - 摘要：Objective:To observe the clinical efficacy of four steps manipulation under brachial plexus anesthesia combined with injection of articular cavity pain point in treating frozen shoulder. Methods90 patients with frozen shoulder were randomly divided into the observation group and control group, 45 cases in each group. The control group was treated with four steps manipulation under brachial plexus anesthesia, and the observation group was treated with injection of articular cavity pain point based on the treatment for the control group, with a treatment course of 8 days and follow-up of 3 months. The clinical efficacy was observed. The changes on the visual analogue scale (VAS) score and the range of motion (ROM) of shoulder were compared. Results:①The total effective rates were 100.0% in the observation group and 86.6% in the control group, the clinical efficacy of the observation group was better than that of the control group (P<0.05). ②Compared with treatment before, the VAS score was decreased in both groups after treatment(P<0.05), the ROM of shoulder including abduction, forward flexion, extension and internal rotation were increased in the observation group (P<0.05), while only the abduction and forward flexion in ROM were increased in the control group (P<0.05). In both groups, there were statistically significant differences on the VAS score and ROM of shoulder between treatment before and after treatment for 3 months (P<0.05). After treatment for 3 months, there were statistically significant differences on the VAS score and ROM of shoulder between the two groups (P<0.05). Conclusion:The therapy of four steps manipulation under brachial plexus anesthesia combined with injection of articular cavity pain point shows satisfactory efficacy in treating frozen shoulder. Compared with four steps manipulation alone, this therapy can more obviously relieve the pain and increase the range of motion of shoulder, which is worthy of promotion and application.关键词：frozen shoulder;brachial plexus anesthesia;manipulation release;injection therapy
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发布时间：2022-08-31 - 摘要：Objective:To observe the clinical efficacy of electroacupuncture at Zusanli and Baliao acupoints on fecal incontinence after complex anal fistula surgery. Methods70 patients with fecal incontinence after complex anal fistula surgery were randomly divided into the treatment group and control group, 35 cases in each group. The control group was treated with electrical stimulation, and the treatment group was treated with electroacupuncture at Zusanli and Baliao acupoints, with a course of 21 days. The clinical efficacy, healing time and recurrence rate were observed. The changes on fecal incontinence score and anorectal pressure were compared. Results:① A total of 69 patients completed the clinical trial, among 34 cases in the control group and 35 cases in the treatment group. ② The total effective rates were 100% in the treatment group and 97.1% in the control group respectively, and there was no statistically significant difference on the clinical efficacy between the two groups (P>0.05). ③ In both groups, the fecal incontinence score was reduced after treatment compared with treatment before (P<0.05). After treatment, the fecal incontinence score in the treatment group was lower than that in the control group (P<0.05). ④ Compared with treatment before, the resting pressure and systolic pressure of anal canal were both increased in the treatment group after treatment (P<0.05), and only systolic pressure of anal canal was increased in the control group (P<0.05). After treatment, the resting pressure of anal canal in the treatment group was higher than that in the control group (P<0.05). ⑤ The healing time in the treatment group was shorter than that in the control group (P<0.05), and the recurrence rate in the treatment group was lower than that in the control group (P<0.05). Conclusion:Electroacupuncture at Zusanli and Baliao acupoints in treating fecal incontinence after complex anal fistula surgery shows satisfactory efficacy. Compared with electrical stimulation, it can better improve the clinical symptoms and increase the anorectal pressure, shorten the course of disease and reduce the recurrence rate.关键词：fecal incontinence;complex anal fistula;post operation;electrical stimulation;electroacupuncture;Zusanli acupoint;Baliao acupoint
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发布时间：2022-08-31 - 关键词：unilateral sweating;hemihidrosis;umbilical moxibustion
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发布时间：2022-08-31 - 摘要：Objective:To investigate the intervention effects of 12 kinds of ethanol extracts of Chinese traditional medicine on TGF-β1 induced epithelial-mesenchymal transition (EMT) in non-small cell lung cancer A549 cells, including Fuling(Poria), Puhuang(Typhae Pollen), Baiji(Bletillae Rhizoma), Jixueteng(Spatholobi Caulis), Yujin(Curcumae Radix), Honghua(Carthami Flos), Niuxi(Achyranthis Bidentatae Radix), Heshouwu(Polygoni multiflora Radix), Huangqi(Astragali seu Hedysari Radix), Xianmao(Curculigins Rhizoma), Luxiancao(Pyrolae Herba)and Baihuashen. MethodsThe A549 cells were stimulated by 10 ng/ml TGF-β1. The effects of 12 kinds of ethanol extracts of Chinese traditional medicine on the proliferation of A549 cells were evaluated by MTT assay. The effects of ethanol extracts on the changes of cell morphology induced by TGF-β1 were observed. The effects of ethanol extracts on the expressions of EMT associated protein biomarkers and the activity of EMT associated signal transduction were detected by Western blot. Results:After stimulation with 10 ng/ml TGF-β1 for 48 hours, the A549 cells showed the EMT process. The ethanol extract of Heshouwu showed no effect on the proliferation of A549 cells. Compared with the TGF-β1 group, the ethanol extract of Heshouwu at 100 μg/ml could reverse the morphological changes of A549 cells. Compared with the TGF-β1 group, the ethanol extract of Heshouwu at 100 μg/ml could decrease the protein expression level of vimentin (P<0.05) and increase the protein expression level of E-cadherin (P<0.05). Compared with the TGF-β1 group, the ethanol extract of Heshouwu at 100 μg/ml could decrease the protein expression levels of p-Smad2 and p-Erk(P<0.05). Conclusion:The ethanol extract of Heshouwu can inhibit the TGF-β1 induced epithelial-mesenchymal transition in A549 cells, which may be associated with Smad2 and Erk1/2 signaling pathway.关键词：non-small cell lung cancer;ethanol extract of Heshouwu (Polygoni multiflora Radix);transforming growth factor-β1;epithelial-mesenchymal transition
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发布时间：2022-08-31 - 摘要：Objective:To evaluate the pharmacodynamics of Furong Ointment on skin ulcer in rats, and provide theoretical basis for its safe and rational application in clinic. Methods40 male SD rats were divided into the blank group, model group, Bactroban (Mupirocin Ointment) group and Furong Ointment group, 10 rats in each group. Except the blank group, the rat model of skin ulcer was established in other groups by infection due to skin scratching. Each group was treated with the corresponding intervention. The effects of Furong Ointment on the related indicators such as body weight, feeding, hair color, activity, ulcer tissue, wound healing time, surface temperature and routine blood indexes were observed. Results:On the fourth day of administration, compared with the blank group, the WBC in the model group was increased significantly (P<0.01), which suggested that the model was successful. Compared with the model group, the WBC in the Bactroban group and the Furong Ointment group was decreased significantly (P<0.05). On the seventh day of administration, compared with the blank group, the MCH and MCHC in the model group were significantly increased (P<0.01). Compared with the model group, the WBC and MCH in the Bactroban group were significantly decreased (P<0.05), and the WBC and MCH in the Furong Ointment group were significantly decreased (P<0.05). On the seventh day of administration, compared with the model group, the number of healed animals was increased significantly in both Bactroban group and Furong Ointment group (P<0.05). After treatment for 3 to 7 days, the score of ulcer was decreased significantly in both groups (P<0.05, P<0.01). Conclusion:Furong Ointment can promote the wound healing.关键词：ulcer model;Furong Ointment;external treatment of Chinese medicine;rat
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发布时间：2022-08-31 - 摘要：Objective:To investigate the effects of Shengjiang Powder on lipopolysaccharide (LPS) induced myocardial injury in septic rats via TLR-4/NF-κB signaling pathway. MethodsThe rat model of acute disease was established by intraperitoneal injection of LPS. The rats were randomly divided into the normal group (n=6), sepsis model group (n=6), Chinese medicine group (n=6) and inhibitor group (n=6). Except the normal group, rats in the other groups were intraperitoneally injected with lipopolysaccharide. The rats in the inhibitor group were injected with miR-146a inhibitor (0.2 μl/g) by intramyocardial administration, and the rats in the Chinese medicine group were treated with Shengjiang Powder by intragastric administration. After 48 hours, the myocardial tissue was collected and homogenized, the pathological changes of myocardial tissue sections were observed. The levels of interleukin (IL)-1, IL-6, tumor necrosis factor-α (TNF-α), and the mRNA activity levels of miRNA-146a, NF-κB, TNF-α, IL-6 and IL-1β were detected. Results:Compared with the normal group, the levels of IL-1, IL-6, TLR4 and NF-κB were increased in the other groups (P<0.05). The TNF-α level in the model group and inhibitor group was higher than that in the normal group (P<0.05). The gene expressions of miR-146a, NF-κB, TNF-α, IL-6 and IL-1 in the model group were increased (P<0.01). The expressions of miR-146a and NF-κB in the Chinese medicine group were increased (P<0.05). The expressions of NF-κB, TNF-α, IL-6 and IL-1 in the inhibitor group were increased (P<0.01). Compared with the model group, the protein levels of TNF-α, TLR4 and NF-κB were decreased in the Chinese medicine group (P<0.05), and the expression of miR-146a was increased, while the gene expressions of NF-κB, TNF-α, IL-1 and IL-6 were decreased (P<0.05). Compared with the model group, the activities of IL-6, TNF-α, TLR4 and NF-κB in the inhibitor group were increased (P<0.01), and the expression of miR-146a was decreased (P<0.01), while the expressions of NF-κB, TNF-α, IL-6 and IL-1 were increased in the inhibitor group. Compared with the inhibitor group, the levels of IL-1, IL-6, TNF-α, TLR4 and NF-κB were decreased in the Chinese medicine group (P<0.01), and the gene expression of miR-146a was increased but the expressions of NF-κB, TNF-α, IL-6 and IL-1 were decreased (P<0.01). Conclusion:Shengjiang Powder can reduce the myocardial damage in sepsis rats, and its mechanism may be associated with promotion on miR-146a expression, negative feedback regulation on TLR-4/NF-κB signaling pathway and inhibition on inflammatory reaction.关键词：Shengjiang Powder;sepsis;TLR-4/NF-κB signaling pathway;myocardial injury;rat
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发布时间：2022-08-31 - 摘要：Objective:To observe the effects of Yiqi Huoxue Huayu Decoction on the expressions of Nephrin mRNA and Podocin mRNA in the renal tissue of rats with membranous nephropathy. MethodsSD rats were randomly divided into the normal control group and modeling group. The passive Heymann nephritis model was established by one-time tail intravenous injection of anti Fx1A serum. After successful molding, the modeling group was randomly divided into the model group, lotensin group, Yiqi Huoxue Huayu Decoction groups with low-, middle- and high-dose. Each group was treated with the corresponding dosage by intragastric administration for 4 weeks, and the 24 h urine volume of rats was collected every week to detect the 24 h urinary protein quantification (UTP). The rats were sacrificed at the end of four weeks, the blood were collected from the heart to detect the serum creatinine (Scr), blood urea nitrogen (BUN), serum total protein (TP), serum albumin (ALB), total cholesterol (TC), high-density lipoprotein (HDL-c) and triglyceride (TG), the kidney tissue was collected to observe the pathological changes after Masson and PASM staining. The IgG and C3 changes were observed by immunofluorescence, and the expressions of Nephrin mRNA and Podocin mRNA were determined by real-time fluorescence PCR. Results:Compared with the normal control group, the UTP level was increased (P<0.05) and the mRNA expressions of Nephrin and Podocin were decreased (P<0.01) in the other five groups. Compared with the model group, the UTP level was reduced (P<0.05) and the mRNA expressions of Nephrin and Podocin were increased (P<0.01) in the drug-treatment groups. The levels of TP and ALB were increased in the drug-treatment groups but with no statistically significant differences (P>0.05), and there were no statistically significant differences on the levels of Scr, BUN, TC, HDL-c and TG between the model group and drug-treatment groups (P>0.05). Compared with the lotensin group, the UTP level was reduced in the Yiqi Huoxue Huayu Decoction groups with low-, middle- and high-dose, but with no statistically significant differences (P>0.05). There were no statistically significant differences on the biochemical indexes between lotensin group and Yiqi Huoxue Huayu Decoction groups (P>0.05). Compared with the lotensin group, the expressions of Nephrin mRNA and Podocin mRNA in the renal tissue were increased in the Yiqi Huoxue Huayu Decoction groups with low-, middle- and high-dose, but with no statistically significant differences (P>0.05). There were no statistically significant differences on all the indexes among the Yiqi Huoxue Huayu Decoction groups with different doses (P>0.05). Conclusion:Yiqi Huoxue Huayu Decoction can significantly reduce the urinary protein level in rats with membranous nephropathy, decrease the renal pathological damage, up-regulate the expressions of Nephrin mRNA and Podocin mRNA in renal tissue and delay the progress of membranous nephropathy.关键词：Yiqi Huoxue Huayu Decoction;membranous nephropathy;Nephrin mRNA;Podocin mRNA;rat
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发布时间：2022-08-31 - 摘要：Objective:To determine the potential chemical compositions and their contents in the different isolated parts (numbered SF-1 to SF-7) of Shaofu Zhuyu Decoction, and observe their effects on eutopic endometrial cells in patients with endometriosis. MethodsThe samples of different parts (SF-1 to SF-7) were prepared by steam distillation, decoction, alcohol precipitation and D101 macroporous adsorption resin. The qualitative and quantitative analysis were performed by high performance liquid chromatography. The volatile oil components were analyzed by gas chromatography-mass spectrometry. The activity screening on each part of Shaofu Zhuyu Decoction was conducted through culturing the eutopic endometrial cells in patients with endometriosis. Results:The different extraction parts of Shaofu Zhuyu Decoction were separated, and the main components and contents of different extraction parts were determined. The different extraction parts promoted the cell growth at low concentrations and inhibited the cells at high concentrations. The activity of different extraction parts were SF-3>SF-4>SF-7>SF-6>SF-5>whole decoction>SF-2>SF-1. Conclusion:The different extraction parts of Shaofu Zhuyu Decoction show the different components and contents, and there are significant differences on the activity between the different extraction parts.关键词：Shaofu Zhuyu Decoction;high performance liquid chromatography;endometriosis;cell;active part
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发布时间：2022-08-31 - 摘要：Objective: To study the inhibitory effects and mechanism of Yiqi Fuzheng Compound Recipe combined with everolimus on xenograft of nude mice with triple negative breast cancer MDA-MB-468 cell line. MethodsThe triple negative breast cancer cell line MDA-MB-468 was cultured in vitro and the cell suspension was inoculated on the second breast pad of female BALB/C nude mice to establish a subcutaneous xenograft model. The successful modeling nude mice were randomly divided into the control group, Yiqi Fuzheng Compound Recipe (Chinese medicine compound recipe) group(40 mg/kg), everolimus group(2 mg/kg)and combination group, 6 mice in each group. Each group was treated with the corresponding drugs by intragastric administration for continuous 30 days. The volume and weight of transplanted tumor in each group were compared, and the tumor inhibition rate was calculated. The mRNA expressions of mTor, Akt, P70s6k and 4Ebp-1 in each group was detected by Real-time PCR. The protein expressions of Akt, p-Akt, m-TOR, p-mTOR, PTEN and p-4EBP-1 and p-P70S6K(as mTOR downstream substrates)were detected by Western blot. Results:Compared with the Chinese medicine compound recipe group, the volume and weight of transplanted tumor in the combination group were decreased significantly(P<0.05,P<0.01), and the tumor inhibition rate was obviously increased. The mRNA expressions of mTor and P70s6k and the protein expressions of p-mTOR and P70S6K in the combination group were obviously lower than those in the Chinese medicine compound recipe group, and the protein expression of PTEN in the combination group was higher than that in the Chinese medicine compound recipe group(P<0.05). Conclusion:The combination of Yiqi Fuzheng Compound Recipe and everolimus can inhibit the growth of tumor tissue in nude mice bearing MDA-MB-468 cell, and the effects are more significant compared with Yiqi Fuzheng Compound Recipe alone. The mechanism may be related to inhibiting the activities of p-mTOR, p-Akt, p-P70S6K and increasing the expressions of p-4EBP-1 and PTEN.关键词：Yiqi Fuzheng Compound Recipe;everolimus;triple negative breast cancer;MDA-MB-468 cell line;nude mouse
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发布时间：2022-08-31 - 摘要：This paper reviews the research progress on the regulation of Chinese medicine on MUC5AC expression in chronic obstructive pulmonary disease. MUC5AC is highly expressed in chronic obstructive pulmonary disease. Single herbs, such as Banxia, Kuxingren and Jiegeing, Chinese medical extracts, such as flavonoid and saponis, Compound recipes such as Qingjin Huatan Decoction, have been proved to regulate the high expression of MUC5AC through various pathways,which provides new ideas for the treatment of chronic obstructive pulmonary disease with Chinese medicine.关键词：Chinese medicine;chronic obstructive pulmonary disease;MUC5AC;review
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发布时间：2022-08-31 - 摘要：This paper reviews the research progress on anticancer mechanism of ginger via multi-targets and multi-pathways. Ginger contains many kinds of plant active ingredients such as gingerol, volatile oil and so on, and shows many pharmacological effects such as anti-inflammatory, antioxidation, inhibiting the proliferation of various cancer cells, promoting the apoptosis of cancer cells, regulating immune, anti-pathogenic microorganism, inhibiting the invasion and metastasis of cancer cells, and slowing down the toxic and side effects of cancer chemotherapy drugs. Ginger and its extracts show many characteristics in the prevention and treatment of cancer, including multiple components, multiple targets, multiple pathways, multiple links, safe and nontoxicity, and present obvious effects in the prevention and treatment of lung cancer,prostate cancer,rectal cancer,skin cancer,liver cancer,breast cancer and so on.关键词：ginger;anticancer;safe and nontoxicity;multi-targets;mechanism;review
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发布时间：2022-08-31
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