最新刊期
期 1 ， 2018
- 摘要：Objective:To observe the clinical efficacy of Modified Buyang Huanwu Granule in the treatment of refractory nephropathy syndrome(RNS). Methods80 RNS patients were randomly divided into the treatment group and control group, 40 cases in each group. The treatment group was treated with the basic therapy of western medicine and Modified Buyang Huanwu Granule,the control group was treated with the basic therapy of western medicine and placebo,with a course of 6 months. The clinical efficacy and medication safety were observed. The changes on the 24 hours urine protein quantitation,renal function indexes,plasma albumin,blood lipid indexes,coagulation indexes,liver function indexes and Chinese medical syndrome score were compared. Results:①The clinical total effective rates of the treatment and control group were 87.5% and 77.5% respectively,and the clinical efficacy of the treatment group was obviously better than that of the control group(P＜0.05). ②After treatment,there was statistically significant difference on Chinese medical syndrome score between the two groups,and the score of the treatment group was obviously lower than that of the control group(P＜0.05). ③Compared with treatment before,the level of 24 hours urine protein quantitation at each timepoint during treatment was obviously decreased in both groups,with statistically significant differences(P＜0.05). From the 16th week of treatment,there were statistically significant differences on the level of 24 hours urine protein quantitation at same timepoint between the control group and treatment group(P＜0.05). ④In both groups,there were statistically significant differences on the levels of BUN,Scr,ALB,TG,TC and LDL between treatment before and after(P＜0.05). After treatment,the levels of BUN,Scr,TG,TC and LDL in the treatment group were significantly lower than those in the control group(P＜0.05),and the level of ALB in the treatment group was significantly higher than that in the control group(P＜0.05). After treatment,there were statistically significant differences on the levels of FIB and D-D between the control group and treatment group,and the levels in the treatment group were obviously lower than those in the control group(P＜0.05). ⑤There was statistically significant difference on incidence rate of adverse reactions between the two groups,and the incidence rate of the treatment group was obviously lower than that of the control group(P＜0.05). Conclusion:Modified Buyang Huanwu Granule in the treatment of refractory nephropathy syndrome can significantly reduce the proteinuria,increase the plasma albumin level,alleviate the disorder of lipid metabolism,improve the blood hypercoagulability and protect the renal function.关键词：refractory nephropathy syndrome;Buyang Huanwu Decoction;randomized controlled trial;placebo;blind trial
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发布时间：2022-08-31 - 摘要：Objective:To investigate the effects of Chaizhi Pinggan Decoction on motilin (MTL),gastrin (Gas),somatostatin (SS) and ghrelin in patients with functional dyspepsia(FD). Methods94 FD patients were randomly divided into the control group and observation group, 47 cases in each group. The control group was orally treated with domperidone tablets,the observation group was orally treated with Chaizhi Pinggan Decoction,with a course of 4 weeks. The changes on the scores of main symptoms and the levels of MTL,Gas,SS and ghrelin were observed in both groups before and after treatment. Results:①After treatment,the clinical symptom scores were decreased in both groups compared with treatment before(P<0.05),and all symptom scores of the observation group were lower than those of the control group(P<0.05). ②Compared with treatment before,the levels of MTL and Gas were increased and the level of SS was decreased in both groups after treatment(P<0.05). After treatment,the levels of MTL and Gas in the observation group were higher than those in the control group(P<0.05),and the level of SS in the observation group was lower than that in the control group(P<0.05). ③Compared with treatment before,the levels of ghrelin in the plasma and gastric mucosa were increased in both groups after treatment(P<0.05). After treatment,the levels of ghrelin in the plasma and gastric mucosa in the observation group were higher than those in the control group(P<0.05). Conclusion:Chaizhi Pinggan Decoction in the treatment of functional dyspepsia can improve the gastrointestinal function through the expression regulation of MTL,Gas,SS and ghrelin.关键词：Chaizhi Pinggan Decoction;functional dyspepsia;ghrelin;motilin;gastrin;somatostatin
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发布时间：2022-08-31 - 摘要：Objective:To observe the clinical efficacy of Qiaojiafang Granule on Hashimoto thyroiditis. Methods70 patients were randomly divided into the Qiaojiafang Granule(QJF)group and selenium yeast tablet(SY)group,35 cases in each group. The treatment group was orally treated with Qiaojiafang Granule, and the control group was orally treated with selenium yeast tablet. The treatment course was 12 weeks in both groups. The thyroid function indexes including serum free triiodothyronine (FT3),serum free thyroxine(FT4) and thyrotropin(TSH),and the levels of thyroid associated antibodies including thyroid peroxidase antibody(TPOAb),thyroglobulin antibody(TGAb)and thyrotropin receptor antibody(TRAb)were observed before and after treatment. And the clinical efficacy was evaluated. Results:Compared with treatment before,there were no obvious changes on the levels of FT3,FT4 and TSH in both groups after treatment(P>0.05). Compared with treatment before,the levels of TPOAb and TGAb were obviously decreased in the QJF group after treatment(P<0.05),but no obvious change on TRAb level was observed. In the SY group,there were no statistically significant differences on the levels of TPOAb,TGAb and TRAb between treatment before and after(P>0.05). After treatment,the levels of TPOAb and TGAb in the QJF group were lower than those in the SY group(P<0.05). The clinical efficacy on Chinese medical syndrome of the QJF group was obviously better than that of the SY group(P<0.01). Conclusion:Qiaojiafang Granule can obviously reduce the levels of thyroid associated antibodies in patients with Hashimoto thyroiditis,and its efficacy is better than selenium yeast tablet.关键词：Hashimoto thyroiditis;Qiaojiafang Granule;thyroid associated antibody
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发布时间：2022-08-31 - 摘要：Objective:To observe the effects of combined acupuncture-drug anesthesia on the anesthesia tolerance and postoperative psychonosema in artificial femoral head replacement of elderly patients. Methods80 elderly patients with femoral neck fracture were randomly divided into the treatment group and control group,40 cases in each group. The control group was treated with minimally invasive artificial femoral head replacement and conventional drug anesthesia,the treatment group was treated with minimally invasive artificial femoral head replacement and combined acupuncture-drug anesthesia. The anesthetic dosage and the level of adrenocorticotropic hormone (cortisol) in peripheral blood were observed during operation,as well as the heart rate and blood pressure at different timepoints and the incidence of postoperative psychonosema. After one-year follow-up,the harris scores on hip joint function were observed. Results:①During operation,there were statistically significant differences on the dosages of fentanyl and propofol between the two groups,and the dosages in the treatment group were obviously less than those in the control group(P＜0.05). ②5 minutes before tracheal catheter extubation,the systolic pressure of the treatment group was obviously lower than that of the control group(P＜0.05). At the moment of tracheal catheter extubation,the heart rate and systolic pressure of the treatment group were obviously lower than those of the control group(P＜0.05). After recovery,the heart rate of the treatment group was obviously lower than that of the control group(P＜0.05). ③During operation,there was no statistically significant difference on the level of cortisol in peripheral blood between the two groups(P＞0.05). ④The incidence rates of postoperative psychonosema were 12.5% in the treatment group and 37.5% in the control group. There was statistically significant difference on the incidence rate between the two groups,and the incidence rate of the treatment group was obviously lower than that of the control group(P＜0.05). ⑤There was no statistically significant difference on the excellent rate of harris scores on hip joint function between the two groups(P＞0.05). Conclusion:The combined acupuncture-drug anesthesia shows no increase in the stress response of elderly patients with artificial femoral head replacement,based on this,it can obviously reduce the dosage of anesthetics and the occurrence of postoperative complications(psychonosema),and improve the patients’ tolerance to anesthesia.关键词：acupuncture anesthesia;conventional anesthesia;minimally invasive joint replacement;stress response;postoperative complications;drug dosage
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发布时间：2022-08-31 - 摘要：Objective:To observe the clinical efficacy of massage therapy combined with conventional western medicine in the treatment of mild-to-moderate carpal tunnel syndrome. Methods110 patients with carpal tunnel syndrome were randomly divided into the control group and treatment group,55 cases in each group. The control group was treated with conventional and conservative therapy of western medicine,the treatment group was additionally treated with massage based on the treatment for the control group,with a course of one month. The Boston carpal tunnel questionnaire(BCTQ)scores,visual analogue scale(VAS)score and electrophysiological indexes of median nerve that including sensory nerve action potential(SNAP),sensory nerve conduction velocity(SNCV),compound muscle action potential(CMAP)and distal motor latency(DML)were observed and compared. Results:①During trial,totally 7 cases fell off. Finally 54 cases in the treatment group and 49 cases in the control group completed the trial. ②After treatment,there were statistically significant differences on the BCTQ scores of symptom dimension and functional dimension between the two groups,and the scores of the treatment group were obviously lower than those of the control group(P＜0.05). ③After treatment,there was statistically significant difference on the VAS score between the two groups,and the VAS score of the treatment group was obviously lower than that of the control group(P＜0.05). ④After treatment,the levels of SNAP and SNCV of middle finger-wrist, SNAP and SNCV of thumb-wrist and CMAP of abductor pollicis brevis in the treatment group were obviously increased compared with the control group(P＜0.05),and the DML level in the treatment group was obviously decreased compared with the control group(P＜0.05). Conclusion:Massage combined with conventional western medicine in the treatment of mild-to-moderate carpal tunnel syndrome can restore the function of hands and wrist,relieve the pain and promote the recovery of local nerve function.关键词：carpal tunnel syndrome;massage;conservative therapy;Boston carpal tunnel questionnaire;electrophysiology of nerve
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发布时间：2022-08-31 - 摘要：Objective:To observe the clinical efficacy of Compound Wuzi Oral Liquid in the treatment of female urethral syndrome. Methods81 patients with female urethral syndrome were randomly divided into the treatment group(40 cases)and control group(41 cases). The control group was treated with tolterodine tartrate,the treatment group was treated with Compound Wuzi Oral Liquid,with a course of 2 months. The changes on the Chinese medical syndrome scores(including single item score and total score),serum levels of estradiol(E2)and follicle stimulating hormone(FSH)were observed. Results:①Finally 35 cases in the treatment group and 37 cases in the control group completed the trial. ②Compared with treatment before,the symptom scores on frequent urination,urgent urination and dribbling urination of the control group were obviously decreased after treatment(P＜0.05),but there were no statistically significant differences on the other symptom scores(P＞0.05)；while all single item scores of the treatment group were obviously decreased after treatment(P＜0.05). After treatment,the symptom scores on soreness and weakness of waist and knees,spiritlessness and weakness,fear of cold and coldness in limbs in the treatment group were significantly lower than those in the control group(P＜0.05). After treatment,the total score of Chinese medical syndrome in the treatment group was significantly lower than that in the control group(P＜0.05). ③There were no statistically significant differences on the serum levels of E2 and FSH in the control group between treatment before and after(P＞0.05),while there were statistically significant differences on the serum levels of E2 and FSH in the treatment group between treatment before and after(P＜0.05). After treatment,there were statistically significant differences on the serum levels of E2 and FSH between the control group and treatment group(P＜0.05). Conclusion:Compound Wuzi Oral Liquid can obviously alleviate the clinical symptoms of patients with female urethral syndrome,such as frequent urination and urgent urination,and improve the estrogen levels.关键词：female urethral syndrome;Compound Wuzi Oral Liquid;Wuzi Yanzong Pill;stranguria caused by overstrain;estrogen
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发布时间：2022-08-31 - 摘要：Objective:To discuss the effects of Jianpi Huayu Decoction on the hemorheology and antioxidant activity in patients with senile macular degeneration(SMD). Methods86 SMD patients(114 eyes)were randomly divided into the observation group and control group,43 cases(57 eyes)in each group. The control group was orally treated with vitamin E tablets,vitamin C tablets and zinc sulfate tablets,and the observation group was treated with modified Jianpi Huayu Decoction,with a course of 3 months. The changes on the clinical symptom score,vision,hemorheology of ophthalmic artery,serum levels of malondialdehyde(MDA)and superoxide dismutase(SOD)were observed in both groups before and after treatment. Results:①Compared with treatment before,the clinical symptom scores were decreased in both groups after treatment,and the vision and visual acuity were increased(P<0.05,P<0.01). After treatment,the clinical symptom score of the observation group was lower than that of the control group,and the vision and visual acuity in the observation group were higher than those in the control group(P<0.05,P<0.01). ②Compared with treatment before,the peak systolic velocity(PSV)and end diastolic velocity(EDV)of ophthalmic artery were increased in both groups after treatment,and the resistance index(RI)was decreased(P<0.05,P<0.01). After treatment,the levels of PSV and EDV in the observation group were higher than those in the control group,and the RI of the observation group was lower than that of the control group(P<0.05,P<0.01). ③Compared with treatment before,the serum MDA level was decreased and the SOD level was increased in both groups after treatment(P<0.05,P<0.01). After treatment,the MDA level in the observation group was lower than that in the control group,and the SOD level in the observation group was higher than that in the control group(P<0.05,P<0.01). Conclusion:Jianpi Huayu Decoction shows good clinical efficacy in the treatment of senile macular degeneration,which can improve the microcirculation in eyes and enhance the antioxidant activity.关键词：senile macular degeneration;Jianpi Huayu Decoction;Hemorheology;antioxidant activity
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发布时间：2022-08-31 - 摘要：Based on inheriting Liu Jiaxiang’s academic thoughts of strengthening vital qi to treat cancer,combined with advances in modern oncology,the theories of tumor pathogenesis in traditional Chinese medicine are innovated,and the view that hidden toxicity due to vital qi deficiency as core pathogenesis of lung cancer onset and metastasis is proposed. It is considered that deficiency of vital qi is the fundamental factor of lung cancer onset,progression and rehabilitation,and the essence of deficiency of vital qi in lung cancer is systematically revealed from immunosenescence,immunoediting,immune-nerve-endocrine dysfunction and other aspects. The purpose of this paper is to deepen the understanding of lung cancer pathogenesis in traditional Chinese medicine,and further provide basis for comprehensive prevention and treatment of lung cancer with traditional Chinese medicine,and provide reference for prevention and treatment of other malignant tumors.关键词：lung cancer;hidden toxicity due to vital qi deficiency;immunosenescence;immunoediting
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发布时间：2022-08-31 - 摘要：This paper discusses the syndrome and treatment of diarrhea due to depression syndrome. Diarrhea,triggered or aggravated by emotional factors and treated effectively based on or combined with relieving depression,can be summarized as diarrhea due to depression syndrome. It mainly contains angry diarrhea,frightened diarrhea,hepatic diarrhea,and diarrhea due to overstrain of heart or spleen or lung. The pathological zang-fu viscera mainly involve the liver,heart,spleen and lung. And the pathogenesis is related to stagnation of liver qi,deficiency of gallbladder qi due to being frightened,worrying damaging the spleen,spiritual exhaustion impairing the heart,grief consuming the lung and so on,which can present at the same time. According to different patterns of diarrhea due to depression syndrome,there are many kinds of treatment,including dispersing stagnated liver qi for relieving qi stagnation,emboldening the courage and relieving convulsion,nourishing heart for tranquillization,tonifying the spleen and invigorating the lung,regulating qi movement and so on. Among the therapy of harmonizing the liver and spleen is the most important and commonly used. And the role of non-drug therapy,such as psychological counseling and adjusting life attitude of patients,also cannot be ignored. In modern medicine,functional diarrhea,irritable bowel syndrome and other functional gastrointestinal disorders induced by psychological factors,as well as diarrhea caused by mental disorders,can be generally classified in the category of diarrhea due to depression syndrome.关键词：depression syndrome;diarrhea;hepatic diarrhea;etiology and pathogenesis;treatment based on relieving depression
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发布时间：2022-08-31 - 摘要：Objective:To discuss the distribution and clinical characteristics of Chinese medical syndromes in upper urinary tract calculi. Methods1064 patients with upper urinary tract calculi were enrolled from Shanghai central urban area. The patterns of Chinese medical syndromes and the clinical characteristics were differentiated. The size of calculus and the hydronephrosis were determined by B-ultrasound. Meanwhile the urinary tract infection and the renal function damage were detected. Results:①In 1 064 cases,the proportion of syndrome of accumulated dampness-heat was the highest(41.17%),followed by syndrome of qi stagnation and blood stasis(24.72%),syndrome of yin deficiency of liver and kidney(11.75%),syndrome of deficiency of kidney yang(11.37%) and other patterns(10.99%)in turn. ②For clinical characteristics,the scores of back pain,hematuria and spasm in lower abdomen were the highest in the syndrome of qi stagnation and blood stasis(P<0.05). The score of urinary irritation was the highest in the syndrome of accumulated dampness-heat(P<0.05).The diameter of calculus was the biggest in the syndrome of deficiency of kidney yang(P<0.05). ③For concurrent symptoms,the proportion of syndrome of qi stagnation and blood stasis combined with hydronephrosis was 41.06%,the proportion of syndrome of accumulated dampness-heat combined with urinary infection was 42.69%,the proportion of syndrome of deficiency of kidney yang combined with renal function damage was 5.79%,which accounted for relative high proportion. Conclusion:The survey in Shanghai central urban area shows that the syndrome of accumulated dampness-heat and syndrome of qi stagnation and blood stasis are the main patterns of Chinese medical syndrome in urinary calculus. There are certain differences on the clinical symptoms and calculi between various patterns.关键词：upper urinary tract calculi;Chinese medical syndrome;clinical characteristic;epidemiology
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发布时间：2022-08-31 - 关键词：pulmonary diseases;treating different diseases with same method;Jingui Shenqi Pill;clinical experience;Liu jianqiu
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发布时间：2022-08-31 - 关键词：tic disorder;co-regulation of liver and lung;Shanghai herbal paste;experience of physician;Wu Min
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发布时间：2022-08-31 - 摘要：This paper introduces Professor Li Bin’s analysis on the etiology and pathogenesis of chronic skin ulcer and his medication experience. It is considered that the diagnosis and treatment should integrate Chinese and western medicine,and take disease differentiation and syndrome differentiation in combination. It is proposed that stasis and deficiency are two key pathological factors,and the treatment should promote granulation and remove blood stasis,clear dampness-heat,regulate spleen and stomach.关键词：chronic skin ulcer;thoughts of differentiation and treatment;Li Bin
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发布时间：2022-08-31 - 关键词：diarrhea;therapy of traditional Chinese medicine;moxibustion;chinical experience;Jiang Hong
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发布时间：2022-08-31 - 关键词：retained fluid disease;Shanghan Zabing Lun(Treatise on Cold Pathogenic and Miscellaneous Diseases);purgation method;classic prescriptions
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发布时间：2022-08-31 - 摘要：Through the proven cases of diabetic peripheral neuropathy,dysmenorrhea,chilblain and Sheehan’s syndrome,this paper introduces the experience with Danggui Sini Decoction in the clinical application. It is considered that Danggui Sini Decoction shows the effects of warming channel for dispelling cold and promoting circulation of meridians,and the key to syndrome differentiation is deadly cold hands and feet with deep,faint and thread pulse. For the syndromes of constitutional blood deficiency,yang qi deficiency,cold pathogen stagnation,impeded circulation of qi and blood,Danggui Sini Decoction can be used in the treatment and modified according to disease condition,which could treat different diseases with same method.关键词：Danggui Sini Decoction;diabetic peripheral neuropathy;dysmenorrhea;chilblain;Sheehan’s syndrome;treating different diseases with same method
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发布时间：2022-08-31 - 摘要：This paper briefly discusses the relationship between elongated needle therapy for qi regulation and circular motion of qi movement in zang-fu viscera. Elongated needle can make deeply needling due to the long needle,which take the advantages of long needle and filiform needle in combination. The key of elongated needle therapy lies in the regulation of qi. The elongated needle therapy for qi regulation emphasizes the spleen and stomach,and regulates the liver and lung. It can disperse lung qi in upper jiao,invigorate the spleen and regulate the stomach in middle jiao,and tonify the kidney and promote excretion in lower jiao,which strengthen the spleen and stomach(as circular axis)and harmonize the liver and lung(as circular wheel),and maintain the proper circular motion of qi movement in zang-fu viscera.关键词：elongated needle;qi regulation;circular motion;qi movement
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发布时间：2022-08-31 - 摘要：This paper summarizes and analyzes the compatibility of qi-supplementing drugs in Furen Gui Antai(Tocolysis Principle for Women). It is considered that Zhang Jingyue made good use of therapy of warming and invigorating based on syndrome differentiation and treatment. For patients with qi deficiency,the treatment should invigorate essential qi in five zang viscera,which combined with blood-nourishing drugs to enrich qi and blood and make relative equilibrium of yin-yang,combined with drugs for dispelling internal cold to warm spleen and stomach for dispelling cold and strengthen vital gate,combined with drugs for activating qi flowing to invigorate spleen and stomach and replenish qi and make the qi movement being in harmonious way,combined with drugs for nourishing yin to clear heat and cool blood and nourish yin for replenishing essence. Through the compatibility of various drugs,the treatments make the blood sufficient,harmonize the five zang viscera and strengthen the original qi of fetus.关键词：Furen Gui Antai(Tocolysis Principle for Women);tocolysis;qi-supplementing drugs;compatibility
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发布时间：2022-08-31 - 摘要：This paper discusses the important significance of theory of liver-wood characterized by bending and straightening in the doctrine of liver viscera picture of traditional Chinese medicine and the clinical hepatopathy. It is considered that this theory should be interpreted as the physiological characteristics and function of liver,including liver being bold and firm viscera as well as soft and mild viscera,liver being substantial yin and functional yang,liver controlling conveyance and dispersion,liver storing blood,liver governing ascending and dredging. In the clinical complicated liver diseases,based on the full understanding of physiological characteristics and function of liver,the conventional therapy such as nourishing and regulating liver,and the flexibly modified therapy which combined with the disease condition,seasons and other organs,can be used in the treatment.关键词：wood characterized by bending and straightening;liver characterized as nature of wood;liver storing blood;liver governing spreading and harmonizing;liver controlling conveyance and dispersion;unity of opposites;general and particular differentiation
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发布时间：2022-08-31 - 摘要：By reviewing the classical documents of Chinese medicine and searching the modern literatures,this paper makes an overview of development of phlegm and fluid retentions in various historical stages,reveals the gradual enrichment trend of doctrine of phlegm and fluid retention,and summarizes the characteristic clinical manifestations in diseases due to phlegm and fluid retention and the representative treatment methods of Chinese medicine.关键词：phlegm and fluid retention;origin;clinical application
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发布时间：2022-08-31 - 摘要：Syndrome of dampness-heat in middle jiao is a common pattern in gastroenterology,and therapy of clearing dampness-heat in middle jiao is the commonly used treatment for this syndrome. Combined with the medical cases,this paper differentiates and analyzes the similarities and differences on syndrome and pathogenesis between Banxia Xiexin Decoction and Huanglian Wendan Decoction,Xiaoxianxiong Decoction and Qingzhong Decoction,Lianpu Decoction and Modified Liansu Decoction,Liangge Powder and Ganlu Xiaodu Pellet,Haoqin Qingdan Decoction and Dachaihui Decoction. It is considered that,both Banxia Xiexin Decoction and Huanglian Wendan Decoction show the effects of opening with pungent and descending with bitter natured drug,the former makes reinforcement and elimination in combination,the latter emphasizes removing phlegm. Both Xiaoxianxiong Decoction and Qingzhong Decoction can treat stomachache,the former focuses on clearing phlegm and regulating qi-flowing,the latter aims at excessive heat in stomach. Both Lianpu Decoction and Modified Liansu Decoction can treat syndrome of adverse rising of stomach qi,the former resolves dampness with aromatics,the latter co-regulates cold and heat. For Liangge Powder and Ganlu Xiaodu Pellet,it should make clear differentiation on disease location. Both Haoqin Qingdan Decoction and Dachaihui Decoction can clear stagnant heat in liver and gallbladder,but the degree of illness is different. In clinical practice,only when the syndrome and pathogenesis characteristics of each recipe are held,the accurate and effective prescriptions could be selected.关键词：dampness-heat in middle jiao;clearing dampness-heat in middle jiao;differentiation of syndrome and pathogenesis
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发布时间：2022-08-31 - 关键词：tumor;common cold;Chaihu Guizhi Decoction
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发布时间：2022-08-31 -
Discussion on clinical application of Danshao Erdi Decoction based on doctrine of insidious pathogen
摘要：Combined with Liu Xianlin’s views on doctrine of insidious pathogen,this paper analyzes doctrine of insidious pathogen. It is considered that the location of disease due to insidious pathogen is heat lodging in xuefen. Combined with the clinical experience,the principle-method-recipe-medicines for disease due to insidious pathogen are established. And based on doctrine of insidious pathogen,the clinical application of Danshao Erdi Decoction is discussed.关键词：doctrine of insidious pathogen;pathogenesis theory;pathogen lodging in xuefen;Danshao Erdi Decoction- 5
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发布时间：2022-08-31 - 摘要：Objective:To optimize the best compatibility of berberine, emodin and cinnamaldehyde in anti-hepatoma activity by uniform design. MethodsThe nude mice were subcutaneously injected with human hepatoma cells under the right axillary to establish the transplantation tumor model. Based on uniform design table U6(64),the grouping design of berberine, emodin and cinnamaldehyde was performed according to “3 factors and 6 levels”. And each group was treated with the corresponding ingredients compatibility. During two-week administration,the changes on the state,death,body weight and tumor volume of mice were observed. After the mice were sacrificed,the tumor was weighed and the tumor inhibition rate was calculated. And the pathological sections of tumor were regularly made. Taken the tumor inhibition rate as primary indicator,the best compatibility of these three ingredients was obtained by regression analysis of uniform design. Results:①No abnormal state and death were found in mice of all groups. ②There was a decreasing trend on body weight of mice in each drug treatment group. ③Compared with the model group,the decreasing trend on tumor volume and tumor weight were observed in each drug treatment group,which suggested that all the treatments showed the tumor inhibitory effects with different degrees. Among,the tumor inhibition rate was 23% in the group P4,and its effect was more significant. ④The characteristic morphology of tumor was observed in the pathological sections,including cellular size and shape,nucleoplasm ratio,karyotype and intercellular matrix. Among,the morphological changes in the group P4 were better than those in the other groups. ⑤After screening,the regression equation was Y=1.95+1.302A-0.253B+0.290C. It meant,when berberine (A),cinnamaldehyde (C) and emodin (B) were 10 μg/g,50 μg/g and 25 μg/g respectively,the compatibility of these three ingredients showed the best inhibitory effects on tumor. Conclusion:The compatibility of berberine, emodin and cinnamaldehyde can effectively inhibit the growth of hepatocellular carcinoma tissue, and the best compatibility ratio is 2∶5∶10.关键词：berberine;emodin;cinnamaldehyde;hepatocellular carcinoma;compatibility of ingredients
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发布时间：2022-08-31 - 摘要：Objective:To explore the inhibitory effects of Jianpi Jiedu Recipe on the transplanted tumor in tumor bearing mice with syndrome of spleen deficiency and the regulatory effects on the intestinal flora in mice with syndrome of spleen deficiency,and discuss the relationship between the two. Methods36 mice from total 48 mice were randomly taken and the mice model of spleen deficiency was established by water decoction of senna. The remaining 12 mice were taken as the normal saline(N.S.)group. Then the model of transplanted tumor was established by CT 26 cells. The 36 model mice of spleen deficiency were randomly divided into the spleen deficiency group and Jianpi Jiedu Recipe(JPJD)groups with low-and high-dose,12 mice in each group. After intragastric administration for continuous 4 weeks,the mice in each group were sacrificed. The tumor was weighed and the inhibition rate was calculated. The thymus index and spleen index were calculated. The proportion of CD4+ and CD8+Tcells was detected by flow cytometry. The serum level of IL-17 was detected by ELISA. The diversity of intestinal flora was determined by 16S rRNA gene sequencing. Results:The average tumor weight and the serum level of IL-17 in the spleen deficiency group were higher than those in the N.S. group and JPJD groups with low-and high-dose,and the thymus index and spleen index,the proportion of CD4+ T cells in peripheral blood and CD4+/CD8+ ratio in the spleen deficiency group were lower than those in the N.S. group and JPJD groups with low-and high-dose,with statistically significant differences(P<0.01). Also,bacteroides was significantly increased and firmicutes was significantly decreased in the intestinal flora of mice in the spleen deficiency group,which showed the obvious dysbacteria. Compared with the N.S. group and JPJD groups with low-and high-dose,bifidobacteria and lactobacillus were decreased and enterobacteria and enterococcus were increased in the spleen deficiency group. Conclusion:Jianpi Jiedu Recipe can inhibit the growth of subcutaneous tumor in tumor bearing mice with syndrome of spleen deficiency,increase the ratio of CD4+/CD8+ and decrease the secretion of IL-17. These effects may be associated with the improvement on alteration of intestinal flora in mice with spleen deficiency.关键词：JianPi JieDu Recipe;spleen deficiency;colorectal cancer;mouse model;alteration of intestinal flora;CD4;+;/CD8;IL-17
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发布时间：2022-08-31 - 摘要：Objective:To study the effects of Longji Xiaozhong Ointment with external application on the pathology of synovial tissue and expressions of related inflammatory factors in rabbit model of knee osteoarthritis,which based on the experience of Yu Zizhen,a famous Chinese medical physician of traumatology in Guang style. Methods60 male New Zealand white rabbits were randomly divided into the blank group,model group,Longji Xiaozhong Ointment group(treatment group)and diclofenac diethylamine group(control group). The model was established in the groups except the blank group,and then the treatment group and control group were treated with Longji Xiaozhong Ointment and diclofenac diethylamine by external application respectively. After administration for 2 weeks,the animal behavior were evaluated by modified Lequesne MG scores,and the rabbits were sacrificed. The synovial tissue of knee joint was collected,the histopathological changes were observed and the expressions of IL-1,IL-6,LT,TNF-α and MMP-3 were detected by ELISA. Results:①Compared with the model group,the activities of rabbits with papain-induced knee osteoarthritis were improved in the treatment group and control group(P<0.05). ②Compared with the model group,the expressions of MMP-3 and IL-1 in the synovial tissue of rabbits with knee osteoarthritis were decreased in the treatment group and control group(P＜0.05,P＜0.01),and there were no statistically significant differences between the treatment group and control group(P>0.05). ③In histopathology,compared with the model group,the local synovitis was improved in the treatment group and control group(P＜0.05). Conclusion:Longji Xiaozhong Ointment can improve the activity and pain of rabbits with knee osteoarthritis. It may be associated with the inhibition of synovial hyperplasia,reduction of synovial fluid production and expression regulation of related inflammatory cytokines.关键词：Longji Xiaozhong Ointment;knee osteoarthritis;synovial hyperplasia;inflammatory cytokines
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发布时间：2022-08-31 - 摘要：Objective:To investigate the influence of rutin on differentiation of 3T3-L1 preadipocytes. MethodsThe differentiation model of 3T3-L1 preadipocytes was established and oil red O staining was performed. Rosiglitazone was taken as the positive control drug. The effects of rutin on the differentiation of 3T3-L1 preadipocytes were observed,and the effect of rutin on the lipid content was detected at wavelength of 510 nm. The effects of rutin on the glucose absorption in differentiated adipocytes were determined by flow cytometry. Results:At the concentrations of 0.5 and 1 μmol/L,rutin could promote the differentiation of 3T3-L1 preadipocytes,increase the lipid content,and promote the glucose absorption. Conclusion:Rutin can promote the differentiation of 3T3-L1 preadipocytes and the glucose absorption in differentiated adipocytes.关键词：rutin;3T3-L1 preadipocytes;differentiation;glucose absorption
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发布时间：2022-08-31 - 摘要：Objective:To discuss the effects of curcumin combined with cisplatin on the expressions of Bcl-2 and caspase-3 in the lung cancer A549 cells. MethodsThe lung cancer A549 cells were divided into the control group, curcumin group, cisplatin group and combination group. Each group was treated with the corresponding drugs. The inhibition rate of cell proliferation was detected by MTT assay. The cell apoptosis rate and cell cycle were detected by flow cytometry. The expression levels of Bcl-2 mRNA and caspase-3 mRNA were detected by RT-PCR,and the protein expression levels of Bcl-2 and caspase-3 were detected by Western blot. Results:①Compared with the control group,the inhibition rates of cell proliferation were increased in the other groups after 24-,48- and 72-hour drug treatment,and the inhibition rate of the combination group was higher than that of the curcumin group or cisplatin group,with statistically significant differences(P<0.05). ②Compared with the control group,the cell apoptosis rates were increased in the other groups,and the apoptosis rate of the combination group was higher than that of the curcumin group or cisplatin group(P<0.05). The cell arrest in G2/M phase was observed in the curcumin group,and the cell arrest in S phase was found in the cisplatin group and combination group. ③Compared with the control group,the mRNA and protein expression levels of Bcl-2 in lung cancer A549 cells were decreased in the other groups. The expression levels in the combination group were lower than those in the cisplatin group,and the expression levels in the cisplatin group were lower than those in the curcumin group(P<0.05). ④Compared with the control group,the mRNA and protein expression levels of caspase-3 in lung cancer A549 cells were increased in the other groups. The expression levels in the combination group were higher than those in the cisplatin group,and the expression levels in the cisplatin group were higher than those in the curcumin group(P<0.05). Conclusion:Curcumin combined with cisplatin can inhibit the expression of Bcl-2 and promote the expression of caspase-3 in lung cancer A549 cells,and thus inhibit the cell proliferation and promote the cell apoptosis.关键词：curcumin;lung cancer;A549 cells;Bcl-2;caspase-3
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发布时间：2022-08-31 - 摘要：Objective:To optimize the extraction process of total flavonoids from Ziziphi Spinosae Fructus. MethodsTaken the solid-liquid ratio, ethanol concentration and extraction time as the indexes, the extraction process of total flavonoids from Ziziphi Spinosae Fructus was optimized by response surface methodology. Results:The optimum extraction conditions were as follows:The extraction time was 1.7 hours, the extraction temperature was 74 ℃, the solid-liquid ratio was 1∶27. The average content of total flavonoids was 1.403 mg/g, and the relative error was 0.31%, which was close to the theoretical prediction. Conclusion:This method is simple, convenient and feasible, which can provide references for the efficient extraction of total flavonoids from Ziziphi Spinosae Fructus as well as subsequent industrial production.关键词：Ziziphi Spinosae Fructus;total flavonoids;extraction process;response surface methodology
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发布时间：2022-08-31 - 摘要：By network search,classification and collection,this paper summarizes the chemical constituents of cornel iridoid glycosides which have reported in domestic and foreign literatures. And the pharmacological effects and pharmacokinetics characteristics of loganin and morroniside with the highest contents are sorted out. The pharmacological effects include inhibition on neurodegenerative diseases(inhibition on Ca2+ imbalance,suppression on oxidative stress damage,protection on nerve,inhibition on cell apoptosis and anti-inflammation),anti-thrombosis,anti-melanin and anti-diabetes.关键词：cornel iridoid glycosides;loganin;morroniside;pharmacological effects;pharmacokinetics;review
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发布时间：2022-08-31 - 摘要：This paper reviews the research progress of Roucongrong(Cistanches Herba)in the treatment of Alzheimer’s Disease,including its general situation,chemical composition,pharmacological effects. The Chinese medical therapy for Alzheimer’s Disease mainly base on tonifying kidney. Roucongrong(Cistanches Herba)shows the effects of tonifying kidney yang and benefiting essence and blood,which is commonly used in Chinese medical therapy for Alzheimer’s Disease. Roucongrong(Cistanches Herba)shows the effects of anti-oxidation,anti-inflammation,immune regulation,promoting metabolism,protecting nerves and so on,which shows good application prospect in the prevention and treatment of Alzheimer’s disease.关键词：Roucongrong(Cistanches Herba);Alzheimer’s disease;tonifying kidney yang;anti-oxidation;anti-inflammation and immune regulation;neuroprotection;review
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发布时间：2022-08-31
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