最新刊期
期 9 ， 2017
- 摘要：This paper introduced Professor Shi Qi’s thinking and tentative ideas about the construction and development of internal medicine of orthopaedics of traditional Chinese medicine,including the connotation,theoretical system,disease treatment methods and significance. He considers that it is not only feasible and necessary but also more urgent for the establishment and development of internal medicine of orthopaedics of traditional Chinese medicine with the characteristics of the times,which could make the contents of orthopedics and traumatology of Chinese medicine more abundant and complete on the original basis,and better guide the clinical practice of orthopedics and traumatology of Chinese medicine.关键词：internal medicine of orthopaedics of traditional Chinese medicine;theoretical system;discipline construction;Shi Qi
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发布时间：2022-08-31 - 摘要：This paper reviewed Professor Cai Xiaosun’s thoughts and experience of kidney regulation in the differentiation and treatment of gynecological diseases. His theory of kidney regulation was discussed from some aspects such as main concepts,theoretical basis,basic principles,basic methods,basic prescriptions,medication characteristics,clinical application and so on. It considered that the thoughts of kidney regulation reflected the view of fertility,syndrome differentiation and treatment of Cai’s gynecology.关键词：Gynecological diseases;kidney regulation;experience of famous doctor;Cai Xiaosun
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发布时间：2022-08-31 - 摘要：This paper introduced the syndrome and treatment of gastric upset due to depression syndrome. From the aspect of disease characteristics,gastric upset fits the feature of indefinite complaints. From the aspect of etiology and pathogenesis,disharmony of liver and stomach,stagnated liver qi transforming into fire,anxiety impairing the heart and spleen as well as stagnation of phlegm-dampness caused by the seven emotions can all lead to gastric upset.From the aspect of treatment prescriptions,dispersing stagnated liver qi and regulating qi-flowing for relieving qi stagnation,invigorating spleen and nourishing heart for tranquillization,activating qi for resolving stagnation and removing phlegm,and even non-pharmaceutical approaches such as psychological counseling can be effective for the treatment. Gastric upset can be seen not only in the general simple spleen-stomach disease,but also in the depression syndrome. Gastric upset due to depression syndrome includes single depression syndrome and coexistence of diseases and depression syndrome. The former mainly refers to liver disease,heart disease and Class Ⅱ spleen disease(spleen-heart disease that belongs to depression syndrome),which should be treated based on relieving depression. The latter refers to liver-stomach disease,which should be treated by both regulating spleen and stomach and relieving depression.关键词：depression syndrome;gastric upset;spleen-stomach disease;spleen-heart disease
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发布时间：2022-08-31 - 摘要：Clinical thinking plays a decisive role in the clinical diagnosis and treatment decisions. The article introduces the clinical thinking of Chinese medical surgery,including prior differentiation of yin and yang,importance of local syndrome differentiation and microscopic syndrome differentiation,combination of constitution differentiation and symptom differentiation that taking disease differentiation as the first and giving priority to syndrome differentiation,internal treatment for external diseases and emphasis on integrity and protection of spleen and stomach,treatment by stages and combination of internal and external treatment and underlining the external therapy. Establishment and reinforcement of clinical thinking of Chinese medical surgery are the key to improve the clinical efficacy,promote the academic level of Chinese medicine and revitalize Chinese medical surgery.关键词：Chinese medical surgery;clinical thinking;treatment based on disease differentiation;treatment based on syndrome differentiation
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发布时间：2022-08-31 - 摘要：Objective:To discuss the intervention effects of moxibustion on knee osteoarthritis. MethodsBy searching resource from data base such as Pubmed,Embase,Cochrane Central Register of Controlled Trials,CINAHL,China national knowledge infrastructure(CNKI),Wangfang and so on,the randomized controlled trials(RCTs)about moxibustion in the treatment of knee osteoarthritis were collected. The quality evaluation and data extraction were performed on the relevant literatures,and the Meta analysis was conducted based on outcome indexes including pain numerical rating scale(NRS)score,SF-36 scale score of quality of life and total score of Western Ontario and McMaster Universities osteoarthritis index(WOMAC). Results:Finally 7 literatures were included,and the quality of the documents was in the medium level. The results of Meta analysis showed that compared with the control group,moxibustion intervention could effectively improve the pain and life quality of patients with knee osteoarthritis,with statistical differences(P<0.05).There was no statistical difference on WOMAC score(clinical symptoms and signs)between the two groups(P>0.05),but the improvement trend was observed in the moxibustion intervention group. Conclusion:Moxibustion intervention can benefit the patients with knee osteoarthritis. Subsequent research should pay attention to the corresponding methodological quality and objective outcome indicators.关键词：moxibustion;knee osteoarthritis;systematic review;Meta analysis
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发布时间：2022-08-31 - 摘要：This paper introduces Professor Wang Xiuxia’s clinical experience in the treatment of intermenstrual bleeding from deficiency of liver yang. She considers the main pathogenesis of intermenstrual bleeding as deficiency of liver yang and dysfunction of dispersion and storing blood. She proposes that the first principles of treatment are warming and nourishing liver yang and regulating qi and regulating menstruation. She pays attention to the application of drugs with effects of warming liver yang,the modified Wengan Tiaojing Decoction is commonly used in the clinical treatment.关键词：intermenstrual bleeding;warming and nourishing liver yang;experience of famous physician;Wang Xiuxia
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发布时间：2022-08-31 - 摘要：This paper introduced Professor Wang Yiqin’s medication characteristics in the treatment ofchildhood asthma. She considers that the main internal factors of this disease are weak body natural endowment,deficiency and impairment of lung,spleen and kidney,phlegm fluid retained in lung and intermingled phlegm and blood stasis,combined with the contact of inducement including exogenous pathogenic factors,diet,emotion and fatigue,which present lung impairment of diffusion and purification and adverse ascending of lung qi as the manifestations and intermingled phlegm and blood stasis as the root cause. In the treatment,the therapy of alleviating asthma,relieving dyspnea and removing phlegm can be used to ease the manifestations,and the therapy of consolidating body resistance,invigorating spleen and benefiting lung can be used to treat the root cause. She makes good use of classical prescriptions,herbal paste and couplet medicines.关键词：childhood asthma;differentiation and treatment;characteristics;Wang Yiqin
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发布时间：2022-08-31 - 关键词：Sini Powder;Shegan Mahuang Decoction;Guizhi Decoction;Yiyi Fuzi Baijiang Powder;Shiwei Decoction;chronic diseases;Treatise on Cold Pathogenic Diseases
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发布时间：2022-08-31 - 摘要：From the topic analysis such as miscellaneous diseases and sudden onset diseases,unification of cold pathogenic and miscellaneous diseases,miscellaneous diseases and internal medicine of traditional Chinese medicine and so on,this paper puts forward some views as follow:Treatise on Cold Pathogenic and Miscellaneous Diseases was written during the clinical practice which aimed at the syndrome and treatment of fever diseases,while miscellaneous diseases should be its supplement and development. A lot of sections in Synopsis of Golden Chamber were adapted or supplemented by descendants,which made its original appearance blurred and really transformed into the specific book of syndrome and treatment of miscellaneous diseases. The concept of miscellaneous diseases had changed later,even tended to internal injury caused by excess of seven emotions. From the clinical perspective,there is close relationship between cold pathogenic and miscellaneous diseases. Therefore,Treatise on Cold Pathogenic and Miscellaneous Diseases is the base,and the later schools of physicians are the expanding and extending,and finally internal medicine of traditional Chinese medicine at present is developed and formed.关键词：Synopsis of Golden Chamber;miscellaneous diseases;cold pathogenic diseases;six meridians
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发布时间：2022-08-31 - 摘要：By analyzing Ye Tianshi’s writings such as Guide to Clinical Practice with Medical Records and Ye’s Medical Cases of Unblock-printed Edition,it found that he did the profound study on Zhang Zhongjing’s therapy of dredging collaterals in Treatise on Cold Pathogenic and Miscellaneous Diseases. Zhang Zhongjing emphasized the therapy of promoting blood circulation for removing blood stasis and obstruction in collaterals,paid attention to the application of insect drugs,and created Xuanfuhua Decoction,Biejia decocted Pill and Dahuang Zhechong Pill,which preliminarily established the theoretical and clinical basis of therapy of dredging collaterals. From clinical practice,based on the principle-method-recipe-medicines in Treatise on Cold Pathogenic and Miscellaneous Diseases to guide the syndrome differentiation and treatment of collateral diseases,Ye Tianshi developed the therapy of dredging collaterals and formed the methods such as dredging collaterals with pungent natured and moistening drugs,dredging collaterals with pungent and warm natured drugs,dredging collaterals with pungent natured drugs and aromatics,dredging collaterals with insect drugs,tonifying deficiency for dredging collaterals and so on,which made great contributions to the inheritance and development of Zhang Zhongjing’s therapy of dredging collaterals.关键词：Ye Tianshi;therapy of dredging collaterals;inheritance;development
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发布时间：2022-08-31 - 摘要：Xu Xiaopu,representative of Xu’s pediatrics,inherited Zhang Zhongjing’s academic theory of warming and nourishing yang,and was well versed the academic thoughts and medical classics of pediatricians since the Northern Song Dynasty,such as Qian Yi,Chen Wenzhong,Wan Quan and so on. He got inspiration from Zhu Weiju’s therapy of warming yang for strengthening vital qi in treating recurring illness,learned the experience without being rigidly adhered to the methods,and created pediatric unique therapy of warming yang,including therapy of relieving superficies syndrome with pungent and warm natured drugs,therapy of warming lung for resolving fluid retention and therapy of warming yang for strengthening vital qi. He emphasized the importance of yang qi in human body,and made good use of Radix Aconiti Lateralis Preparata to treat chronic diseases in children.关键词：Xu Xiaopu;academic thoughts of warming yang;pediatric clinical diagnosis
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发布时间：2022-08-31 - 摘要：Objective:To observe the clinical efficacy of Huoxue Qianyang Qutan Recipe in treating obese patients with hypertension and the intervention effects on left ventricular remodeling. Methods90 obese patients with hypertension and left ventricular remodeling were randomly divided into the treatment group and control group,45 cases in each group. The control group was treated with the original therapy of western medicine and health education,and the treatment group was additionally treated with Huoxue Qianyang Qutan Recipe based on the treatment for the control group,with a course of 3 months. The indexes of body shape,blood pressure in consulting room,ambulatory blood pressure,TCM syndrome score,indicators of glucose and lipid metabolism and indexes of cardiac structure were observed and compared. Results:①Until the end of trial,a total of 82 cases completed the whole trial,among 40 cases in the treatment group(5 cases fell off)and 42 cases in the control group(3 cases fell off).The total expulsion rate was 8.9%. ②After treatment,there were statistically significant differences on the levels of body weight,waistline and body mass index(BMI)between the two groups,and the improvement on body obesity in the treatment group was significantly better than that in the control group(P<0.05). ③After treatment,there were statistically significant differences on the systolic and diastolic blood pressure in consulting room between the two groups,and the hypotensive effects of the treatment group were more significant than those of the control group(P<0.05). ④After treatment,there were statistically significant differences on the 24 h mean systolic pressure and night mean systolic pressure between the two groups(P<0.05). ⑤After treatment,there was statistically significant difference on TCM syndrome score between the two groups,and the TCM syndrome score of the treatment group was obviously lower than that of the control group(P<0.05). ⑥After treatment,there were statistically significant differences on the levels of total cholesterol,triacylglycerol,low density lipoprotein,fasting insulin and insulin resistance index between the two groups,and the levels of the treatment group were obviously lower than those of the control group(P<0.05). ⑦After treatment,there were statistically significant differences on the levels of interventricular septal thickness(IVST),left ventricular mass(LVM)and left ventricular mass index(LVMI)between the two groups,and the levels of the treatment group were obviously decreased compared with the control group(P<0.05). Conclusion:Huoxue Qianyang Qutan Recipe can obviously improve the obese condition and glucose and lipid metabolism of obese patients with hypertension,which further improve the blood pressure on the basis of original antihypertensive program and also improve the left ventricular remodeling in a certain extent.关键词：essential hypertension;central obesity;left ventricular remodeling;glucose and lipid metabolism;Huoxue Qianyang Qutan Recipe
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发布时间：2022-08-31 - 摘要：Objective:To observe the clinical efficacy and safety of Modified Gegen Qinlian Decoction combined with basic therapy in the treatment of acute infectious diarrhea with syndrome of intestinal dampness-heat. MethodsA multi-center,randomized,double-blind and placebo-controlled clinical study was performed. 144 patients of acute infectious diarrhea with syndrome of intestinal dampness-heat were randomly divided into the treatment group and control group,72 cases in each group. Both groups were treated with basic therapy of western medicine,and the treatment group was treated with Modified Gegen Qinlian Decoction and the control group was treated with placebo of Chinese medicine additionally. The treatment course in both groups was 3 days. The clinical efficacy was observed,and the changes of TCM syndrome score,antidiarrheal time and leukocytes in fecal microscopic examination were compared. Results:①During trial,a total of 9 cases were excluded or fell off,and finally 135 cases completed the trial. There were 139 cases in analysis set of modified intent-to-treat(MITT)or safety analysis(SA),among 69 cases in the treatment group and 70 cases in the control group. There were 135 cases in analysis set of per-protocol(PP),among 68 cases in the treatment group and 67 cases in the control group. ②The clinical total effective rate was 94.20% in the treatment group and 85.71% in the control group. The clinical efficacy of the treatment group was significantly better than that of the control group(P<0.05). ③There was statistically significant difference on the average antidiarrheal time between the two groups,and the average antidiarrheal time of the treatment group was obviously less than that of the control group(P<0.05). ④For the comparison between treatment before and after,there was statistically significant difference on the normal rate of leukocytes in fecal microscopic examination in both groups(P<0.05). After treatment,there was no statistically significant difference on the normal rate of leukocytes in fecal microscopic examination between the two groups(P>0.05). ⑤ No adverse reaction was observed in both groups. There was no statistically significant difference on the incidence of adverse reaction between the two groups(P>0.05). Conclusion:Modified Gegen Qinlian Decoction combined with basic therapy of western medicine can significantly improve the clinical symptoms of patients with acute infectious diarrhea,and effectively shorten the diarrhea time.关键词：acute infectious diarrhea;intestinal dampness-heat;diarrhea;Gegen Qinlian Decoction;antidiarrheal time
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发布时间：2022-08-31 - 摘要：Objective:To observe the clinical efficacy of Huoxue Zhitong Powder combined with western medicine in the treatment of early diabetic foot. Methods120 patients with early diabetic foot were randomly divided into the treatment group and control group,60 cases in each group. The control group was treated with routine therapy of western medicine,and the treatment group was orally treated with Huoxue Zhitong Powder based on the treatment for the control group,with a course of 20 days. The clinical efficacy was observed,the changes of blood sugar level,ankle-to-brachial ratio index(ABI)and toe-to-brachial ratio index(TBI)in foot,deep and superficial sensation and motor sensory nerve conduction velocity were compared. Results:①The clinical total effective rate was 80.00% in the treatment group and 55.00% in the control group. The clinical efficacy of the treatment group was significantly better than that of the control group(P<0.05). ②After treatment,there were statistically significant differences on the levels of fasting plasma glucose(FPG)and 2h postprandial glucose(2h PG)between the two groups,and the levels of the treatment group were obviously lower than those of the control group(P<0.05). ③After treatment,there were statistically significant differences on the ABI and TBI between the two groups,the ratio indexes of the treatment group were obviously higher than those of the control group(P<0.05). ④After treatment,there were statistically significant differences on the levels of deep and superficial sensation between the two groups,and the improvement on sensory function in the treatment group was obviously better than that in the control group(P<0.05). ⑤After treatment,there were statistically significant differences on the conduction velocity of common peroneal nerve and median nerve between the two groups,and the conduction velocity in the treatment group were obviously faster than those in the control group(P<0.05). Conclusion:Huoxue Zhitong Powder combined with western medicine in the treatment of early diabetic foot can obviously alleviate the clinical symptoms of patients,reduce the blood sugar level,improve the deep and superficial sensation and neurological function in foot,and thus effectively control the disease development.关键词：diabetes mellitus;diabetic foot;early prevention and treatment;promoting blood circulation to arrest pain;deep and superficial sensation;neurological function;integrated traditional Chinese and western medicine
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发布时间：2022-08-31 - 摘要：Objective:To observe the effects of Modified Xiayuxue Decoction combined with acetylcysteine on interstitial pulmonary fibrosis. Methods60 patients with interstitial pulmonary fibrosis were randomly divided into the treatment group and control group,30 cases in each group. The treatment group was treated with Modified Xiayuxue Decoction combined with acetylcysteine,and the control group was treated with acetylcysteine,with a course of 6 months. The TCM syndrome score,pulmonary function indexes,6-minute walk distance,St. Georges respiratory questionnaire(SGRQ)score for life quality evaluation and high resolution CT(HRCT)score were observed and compared. Results:①Compared with treatment before,the TCM syndrome score and SGRQ score were decreased and 6-minute walk distance was increased in both groups after treatment,with statistical differences(P<0.05).There were statistically significant differences on the TCM syndrome score,SGRQ score and 6-minute walk distance between the two groups after treatment(P<0.05). ②After treatment,the diffusing capacity for carbon monoxide of single breath(DLCO·SB)in the treatment group was increased(P<0.05),but there were no obviously changes of all pulmonary function indexes in the control group(P>0.05). The DLCO·SB in the treatment group was higher than that in the control group after treatment(P<0.05). ③For the comparison between treatment before and after within group or between the two groups after treatment,there was no statistically significant difference on HRCT score. Conclusion:Modified Xiayuxue Decoction combined with acetylcysteine can be used in the treatment of interstitial pulmonary fibrosis,which can improve the TCM syndrome and alveolar diffusion function of patients,enhance the exercise tolerance and life quality,and prevent the progression of pulmonary fibrosis.关键词：interstitial pulmonary fibrosis;therapy of integrated Chinese and western medicine;Modified Xiayuxue Decoction
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发布时间：2022-08-31 - 摘要：Objective:To observe the effects of Chinese herbal medicine of invigorating spleen and softening liver or bromocriptine combined with Bushen Huoxue Antai Recipe on pregnancy outcome in patients of recurrent spontaneous abortion(RSA)with hyperprolactinemia(HPRL). Methods326 RSA patients with HPRL were randomly divided into the treatment group and control group,163 cases in each group. Both groups were treated with Bushen Huoxue Antai Recipe. The treatment group was treated with Chinese herbal medicine of invigorating spleen and softening liver(unprocessed Fructus Hordei Germinatus,unprocessed Fructus Setariae Germinatus,Radix Paeoniae Alba,unprocessed Radix Glycyrrhizae)and the control group was treated with bromocriptine additionally. The total treatment course in both groups was 12 weeks. The normal rate of 12-week pregnancy and pregnancy outcome were observed and compared. Results:①Finally 319 patients completed the trial,among 161 cases in the treatment group and 158 case in the control group. ②The normal rate of 12-week pregnancy was 86.3%in the treatment group and 85.3%in the control group. There was no statistically significant difference on the normal rate between the two groups(P>0.05).The non inferiority test for two sample rate was up to standard(P<0.01). ③The successful parturition rate was 83.2% in the treatment group and 81.5%in the control group. There was no statistically significant difference on the successful parturition rate between the two groups(P>0.05). The non inferiority test for two sample rate was up to standard(P<0.01). Conclusion:After pregnancy confirmation,the tocolysis effects of Bushen Huoxue Antai Recipe combined with Chinese herbal medicine of invigorating spleen and softening liver are equivalent to the effects of Bushen Huoxue Antai Recipe combined with bromocriptine. Compared with bromocriptine,the side reactions of Chinese herbal medicine of invigorating spleen and softening liver are less,which accepted more easily by patients.关键词：hyperprolactinemia;recurrent spontaneous abortion;tonifying kidney and promoting blood circulation;invigorating spleen and softening liver;bromocriptine;side reaction
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发布时间：2022-08-31 - 摘要：Objective:To observe the effects of five phases music of Chinese medicine on cancer pain and quality of life in middle and advanced cancer patients. Methods100 cancer patients with cancer pain were randomly divided into the treatment group and control group,50 cases in each group. Both groups were treated with basic therapy of western medicine. Additionally,the treatment group was treated with therapy of five phases music of Chinese medicine and the control group was treated with therapy of western natural music,with a course of 30 days. The score changes of numeric rating scales(NRS),quality of life questionnaire for cancer patients(QLQ-C30)and Eastern Cooperative Oncology Group performance status(ECOG-PS)scale were observed and compared. Results:①After treatment,there were statistically significant differences on the NRS score grades between the two groups,and the relief of pain symptoms in the treatment group was obviously better than that in the control group(P<0.05). ②For the comparison between the two groups after treatment,the differences on the score of overall health condition and the scores of all symptom items,all single items and all function items in QLQ-C30 were statistically significant,the improvement on life quality in the treatment group was obviously better than that in the control group(P<0.05). ③After treatment,there were statistically significant differences on the ECOG-PS scores between the two groups,the improvement on performance status in the treatment group was obviously better than that in the control group(P<0.05). Conclusion:The therapy of five phases music of Chinese medicine can significantly improve the quality of life of cancer patients,reduce their cancer pain sense and enhance the performance status.关键词：cancer;middle and advanced stage;cancer pain;therapy of five phases music;non-drug therapy;quality of life
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发布时间：2022-08-31 - 摘要：Objective:To observe the clinical efficacy of Tengtong Formula with external application in the treatment of acute soft tissue injury after type B ankle fracture (AO classification). Methods60 patients with type B ankle fracture were randomly divided into the Voltaren group and Tengtong Formula group,30 cases in each group. Both groups were treated with conventional measures including lifting affected limbs,stopping activities and immobilization. Meanwhile the Voltaren group was treated with Votalin Emulgel(diclofenac diethylamine emulgel)by external application,and the Tengtong Formula group was treated with Tengtong Formula by external application. Before treatment,24 and 48 hours after injury,the limb circumference difference of affected limb,visual analogue scale(VAS)score,serum trauma indicator creatine kinase(CK),serum inflammation indicators including C-reactive protein(CRP) and interleukin-6(IL-6)were determined,and the adverse events(skin allergy,incisional infection,incision delayed union)were observed during follow-up. Results:①In the Voltaren group,the limb circumference difference was increased progressively during 48 hours after injury. In the Tengtong Formula group,the limb circumference difference was up to peak at 24 h and was significantly decreased at 48 h after injury,and the limb circumference difference at 48 h was lower than that at 24 h or before treatment(P<0.05). 48 hours after injury,the limb circumference difference in the Tengtong Formula group was also significantly lower than that in the Voltaren group(P<0.05). There was definite analgesic effect in the Voltaren group and Tengtong Formula group,with no statistical difference(P>0.05). ②There were no statistically significant differences on serum CK level among each observation timepoint in the Voltaren group(P>0.05)；while in the Tengtong Formula group,the serum CK level at 48 h was significantly lower than that at 24 h or before treatment(P<0.05). Compared with treatment before,the levels of CRP and IL-6 were significantly increased at 24 h and 48 h in the Voltaren group(P<0.05),and the levels of CRP and IL-6 were significantly decreased at 48 h in the Tengtong Formula group(P<0.05). 48 hours after injury,the levels of CRP and IL-6 in the Tengtong Formula group were significantly lower than those in the Voltaren group(P<0.05). ③There was no statistically significant difference on the incidence of adverse events between the two groups(P>0.05). Conclusion:Tengtong Formula can effectively reduce the pain and limb swelling of patients with acute soft tissue injury after type B ankle fracture,improve the serum trauma and inflammation indicators. Its effects of relieving swelling and suppressing inflammation are better than that of Votalin Emulgel,with no obvious increasing on incidence of adverse events.关键词：ankle fracture;acute soft tissue injury;Tengtong Formula;external application
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发布时间：2022-08-31 - 摘要：Objective:To observe the effects of Xiaoyin Decoction on immune function in patients of psoriasis vulgaris with syndrome of blood-heat. Methods78 patients of psoriasis vulgaris with syndrome of blood-heat were randomly divided into the control group and observation group,39 cases in each group. The control group was treated with routine therapy of western medicine,and the observation group was additionally treated with Xiaoyin Decoction based on the treatment for the control group,with a course of 2 months. The clinical efficacy of both groups was observed,and the changes of T lymphocyte subsets in peripheral blood and immune indexes of erythrocytes were compared before and after treatment. Results:①The total effective rate was 82.05% in the control group and 97.44% in the observation group. The clinical efficacy of the observation group was obviously better than that of the control group(P<0.05). ②Compared with treatment before,the levels of CD3+,CD4+ and CD3+CD4+ in peripheral blood were decreased(P<0.05)and the CD8+ level was increased(P<0.05)in both groups. The improvement on all indicators in the observation group was better than that in the control group(P<0.05). ③After treatment,the FEIR level was decreased(P<0.05)and the levels of FEER,ATER and RBC-C3bR were increased(P<0.05)in both groups. The improvement on immune indexes of erythrocytes in the observation group was better than that in the control group(P<0.05). Conclusion:Xiaoyin Decoction shows good clinical efficacy in the treatment of psoriasis vulgaris with syndrome of blood-heat,and can significantly improve the immune state of patients.关键词：Xiaoyin Decoction;psoriasis vulgaris;blood-heat syndrome;immune function
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发布时间：2022-08-31 - 摘要：Objective:To observe the clinical efficacy of desloratadine citrate disodium combined with Yupingfeng Granule in the treatment of chronic urticaria. Methods86 patients of chronic urticaria (CU) were divided into the control group and treatment group according to random number table,43 cases in each group. The control group was orally treated with desloratadine citrate disodium,and the treatment group was orally treated with Yupingfeng Granule based on the treatment for the control group,with a course of 4 weeks. The clinical efficacy was observed,the disease severity was evaluated by urticarial activity scale(UAS),the life quality was assessed by dermatology life quality index(DLQI),and the changes of serum interleukin-4(IL-4),interferon-γ(IFN-γ)and immunoglobulin E(IgE)were detected. Results:①The total effective rate was 72.09% in the control group and 90.70% in the treatment group. The clinical efficacy of the treatment group was obviously better than that of the control group(P<0.05). ②After treatment,the symptom scores of pruritus and wheal were decreased in both groups(P<0.01),and the scores of the treatment group were lower than those of the control group(P<0.01). ③After treatment,the DLQI was significantly decreased in both groups(P<0.01),and the DLQI of the treatment group was lower than that of the control group(P<0.01). ④After treatment,the levels of IL-4 and IgE were decreased and the IFN-γ level was increased in both groups(P<0.05),and the improvement in the treatment group was better than that in the control group(P<0.05). Conclusion:Desloratadine citrate disodium combined with Yupingfeng Granule shows definite clinical efficacy in the treatment of chronic urticaria,which can enhance the life quality and improve the immune state of patients.关键词：Urticaria;desloratadine citrate disodium;Yupingfeng Granule;IgE
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发布时间：2022-08-31 - 关键词：toothache;pain of wisdom tooth;moxibustion;Jianghuang Powder;Zhang Jingyue
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发布时间：2022-08-31 - 摘要：By analyzing the thoughts of five evolutive phases and six climatic factors in Chen Wuze’s original work,combined with the comparison with Ziwan Decoction including the sources,compositions and similar prescriptions,it considered that this recipe was formulated according to the time phase and meteorological characteristics of five evolutive phases and six climatic factors,which run through Chen Wuze’s idea of harmony between human body and natural environment and reflected the academic characteristics of treatment based on five evolutive phases and six climatic factors differentiation. In clinical application,it should pay attention to the differentiation of five evolutive phases and six climatic factors,pathogenesis differentiation and mechanism differentiation,and combine with deficiency and excess of zang-fu viscera and natural cold and heat. This recipe showed definite clinical efficacy in lung and related systems diseases,and the clinical proven case was presented.
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发布时间：2022-08-31 - 摘要：“Truncation therapy” refers to the prior medication in a variety of acute infectious diseases,which could cut off the disease transformation in early stage and suppress the disease development. There is also a certain trend in the development of chronic diseases,so it considers that truncation therapy can be applied in the prevention and treatment of chronic diseases such as gastric precancerous lesions. Rostellularia procumbens(L.)Nees shows the effects of clearing heat-toxicity,promoting diuresis for removing food retention and activiting blood circulation for promoting tissue regeneration,which corresponds with the key pathogenesis of gastric precancerous lesions(internal stagnation of blood stasis and toxin). It is safe and effective in clinic,and can be used as the specific drug for cutting off the natural and prolonged development of gastric precancerous lesions.关键词：Rostellularia procumbens(L.)Nees;clearing heat-toxicity;promoting diuresis for removing food retention;activiting blood circulation for promoting tissue regeneration;truncation therapy
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发布时间：2022-08-31 - 摘要：Objective:To study the effects of medicated serum of Pingmu Decoction on protein expressions of FAS,FAS L,CHOP and CASPASE-4 in orbital adipocytes in Graves’ ophthalmopathy,and discuss the mechanism of apoptosis in orbital mature adipocytes. MethodsThe orbital preadipocytes from patients with Graves’ ophthalmopathy were cultured in vitro,and differentiated into the mature adipocytes after cell passage and induction. The medicated serum of Pingmu Decoction were prepared,which divided into the low-,medium- and high-dose group with the final concentrations as 5%,10% and 20% respectively. The proliferation of preadipocytes was detected by MTT assay. The effects of medicated serum of Pingmu Decoction on protein expressions of FAS,FAS L,CHOP and CASPASE-4 in orbital mature adipocytes were detected by Western blotting. Results:①The MTT assay showed that,compared with the blank control group,the growth curve was significantly downward in the Pingmu Decoction groups with low-,medium- and high-dose,and the decrease trend of activities in the medium-dose group was the most significant. There was no statistically significant difference between the dexamethasone group and blank control group(P>0.05). Compared with the blank control group at the same timepoint,the OD value was decreased in the Pingmu Decoction groups with low-,medium- and high-dose,and the decrease in the medium-dose group was the most significant with statistical difference(P<0.05). ②The results of Western blotting showed that,except the dexamethasone group,compared with the blank control group,the protein expressions of FAS and FAS L were up-regulated in the Pingmu Decoction groups with different doses,with statistical differences(P<0.05). The protein expression of FAS was highest in the medium-dose group,followed by low-dose group；the protein expression of FAS L was highest in the high-dose group,followed by medium-dose group,but there was no statistically significant difference between these two groups. Except the dexamethasone group,compared with the blank control group,the protein expressions of CHOP and CASPASE-4 were up-regulated in the Pingmu Decoction groups with different doses,with statistical differences(P<0.05).The protein expression of CHOP was highest in the high-dose group,followed by medium-dose group；the protein expression of CASPASE-4 was highest in the medium-dose group,followed by low-dose group. Conclusion:Pingmu Decoction can induce the activation of FAS,FAS L,CHOP and CASPASE-4 through death receptor and endoplasmic reticulum pathway,promote the apoptosis of mature adipocytes,and then reduce the accumulation of orbital adipocytes,which plays the therapeutic role.关键词：Pingmu Decoction;non-active Graves’ ophthalmopathy;orbital adipocytes;apoptosis;Fas;FAS L;CHOP;CASPASE-4
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发布时间：2022-08-31 - 摘要：Objective:To study the effects of electroacupuncture on Yintang(EX-HN3)and Baihui(GV20)acupoints on the contents of second messengers cyclic adenosine monophosphate(cAMP)and cyclic guanosine monophosphate(cGMP)in model rat of chronic stress depression,and reveal the possible mechanism of electroacupuncture in the treatment of depression. Methods32 Sprague-Dawley male rats were randomly divided into the normal control group,model group,electroacupuncture group and fluoxetine group,8 rats in each group. Except the normal control group,the rats in the other groups were raised separately and treated with the chronic unpredictable stress stimulation to establish the model. One day before and 21st day of after stress stimulation,the rats in each group were performed the open field test respectively,and the behavioral changes of rats were observed. The contents of cAMP and cGMP in hippocampus of rats were detected by radioimmunoassay. Results:Compared with the normal control group,the horizontal and vertical movement of rats in the model group were significantly decreased(P<0.01),and the exploration ability of rats was decreased. Compared with the model group,the horizontal and vertical movement of rats in the electroacupuncture group and fluoxetine group were obviously increased(P<0.05),and the activity of rats was increased. Compared with the normal control group,the cAMP content was decreased and the cGMP content was increased in the model group,and the ratio of cAMP/cGMP was reduced,with statistically significant differences(P<0.01). Compared with the model group,the cAMP content was increased and the cGMP content was decreased in the electroacupuncture group and fluoxetine group,and the ratio of cAMP/cGMP was increased,with statistically significant differences(P<0.05). Conclusion:Regulating the contents of cAMP and cGMP in central nervous system to balanced state is one of the possible mechanisms of electroacupuncture in the treatment of depression.关键词：electroacupuncture;depression;hippocampus;cAMP;cGMP
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发布时间：2022-08-31 - 摘要：Objective:To observe the effects of Gegen Qinlian Pill on mose model of rotavirus diarrhea with dampness-heat syndrome(RV-DH)and the mechanism on immune barrier dysfunction of intestinal mucosa. Methods80 BLAB/C mice were randomly divided into 8 groups. The mouse model of syndrome of dampness-heat in large intestine and mouse model of RV-DH with syndrome of dampness-heat in large intestine were established respectively. After successful modeling,except the model group,the other groups were treated with Gegen Qinlian Pill,montmorillonite powder(Smecta)and drug combination respectively. The intestinal mucosal shielding function in mice was detected by FITC-Dextran. The levels of SIgA,IL-1β,IL-2,IL-6,IL-8 and TNF-α were detected by ELISA. The pathology of large intestine in mice was observed by HE staining. Results:①The FITC-Dextran detection showed that,in mouse model of syndrome of dampness-heat in large intestine,the FD4 level was decreased in the Chinese medicine group,Smecta group and combination group compared with the model group,and the therapeutic efficacy of the combination group was the most significant. In mouse model of RV-DH with syndrome of dampness-heat in large intestine,the trends in the treatment groups after drug intervention were consistent with those in mouse model of syndrome of dampness-heat in large intestine. ②The ELISA detection indicated that,in mouse model of syndrome of dampness-heat in large intestine,the levels of SIgA,IL-1β,IL-2,IL-6,IL-8 and TNF-α in large intestine and lung tissue were decreased in the Chinese medicine group,Smecta group and combination group compared with the model group,and the efficacy of the combination group was the most significant. In mouse model of RV-DH with syndrome of dampness-heat in large intestine,the trends in the treatment groups after drug intervention were consistent with those in mouse model of syndrome of dampness-heat in large intestine. The intestinal mucosal barrier function in mice was improved in all drug treatment groups. ③The observation of HE staining suggested that the acute inflammatory reactions were alleviated in all drug treatment groups,and the number of infiltrating lymphocytes in submucosa was decreased and the intestinal mucosal damage was improved. The efficacy of the combination group was the most significant. Conclusion:Gegen Qinlian Pill shows certain effects of immune regulation. It can regulate lymphocytes and inhibit TNF-α in intestinal homogenate,which may be one of its mechanisms in the treatment of rotavirus diarrhea with dampness-heat syndrome.关键词：Gegen Qinlian Pill;diarrhea;rotavirus;dampness-heat model;mice
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发布时间：2022-08-31 - 摘要：Objective:To observe the effects of inhibiting invasion and inducing apoptosis of tanshinone ⅡA(TanⅡA) in human cervical squamous carcinoma SiHa cells,and discuss its possible mechanism. MethodsThe human cervical squamous carcinoma SiHa cell lines were routinely cultured in vitro and treated with TanⅡA at concentration of 0.5,1.0,2.0 and 5.0 mg/L respectively. Then the cells were cultured for 24 hours. The morphological changes of the cells were observed by inverted microscope. The cell proliferation was detected by MTT assay,the effect of TanⅡA on cell migration was detected by cell scratch test,the inhibitory effect of TanⅡA on SiHa cell invasion was detected by Transwell test,and the change of SiHa cell apoptosis was observed by laser scanning confocal microscope. The protein expressions of MMP-2 and NF-κB p65 were detected by Western blotting. Results:The morphological observation showed that tanshinone ⅡA with different concentrations could all lead to the changes of cell morphology. MTT assay indicated that tanshinone ⅡA showed the obviously inhibitory effect on SiHa cells growth,and the inhibitory effect was increased with the increasing drug concentration(P<0.05,P<0.01). The result of scratch test showed that the SiHa cell migration was decreased with the increasing TanⅡA concentration(P<0.01). The Transwell test suggested that TanⅡA showed strong inhibitory effect on SiHa cell invasion in vitro. The results of Western blotting showed that TanⅡA could inhibit the protein expression of MMP-2 and activation of NF-κB p65 in SiHa cells(P<0.01). Conclusion:TanⅡA can inhibit the invasion and induce the apoptosis in human cervical squamous carcinoma SiHa cells,and its possible mechanism may be associated with inhibiting NF-κB activation and down-regulating MMP-2 expression.关键词：tanshinone ⅡA;human cervical squamous carcinoma cells;cell invasion;MMP-2
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发布时间：2022-08-31 - 摘要：Objective:To observe the effects of Qinghua Gushen Paidu Decoction on the expressions of Notch1 and Jagged1 in renal tissue of rats with unilateral ureteral obstruction (UUO),and discuss its mechanism on renal fibrosis. Methods72 SD rats of SPF grade were randomly divided into the sham operation group,UUO model group,Lotensin group and Qinghua Gushen Paidu Decoction(QHGSPD)group. Except the sham operation group,rat model of renal fibrosis obstruction was established by unilateral ureteral ligation in the other groups. After operation,the rats in each group were treated with the corresponding drugs or 0.9% NaCl solution by intragastric administration once a day. 7,14 and 21 days after modeling,the rats in each group were fasted but drunk water freely for one day and then sacrificed. The renal tissue of obstructed side was collected,and the pathological changes of renal tissue were observed after Masson staining microscope. The protein and mRNA expressions of Notch1 and Jagged1 were detected by immunohistochemistry and real-time PCR(RT-PCR)respectively. Results:As the time of ureteral obstruction prolonged,the degree of renal interstitial fibrosis gradually aggravated. After Masson staining,there was significant difference on the index of renal fibrosis between the model group and sham operation group(P<0.05).Compared with the model group,the degree of renal fibrosis in the QHGSPD group and Lotensin group was relatively alleviated,with statistical difference(P<0.05).The results of immunohistochemistry and PCR showed that the expressions of Notch1 and Jagged1 in renal tissue of rats in the QHGSPD group and Lotensin group were significantly lower than those in the model group(P<0.05).There were no statistically significant differences on the expressions of Notch1 and Jagged1 between the QHGSPD group and Lotensin group(P>0.05). Conclusion:Qinghua Gushen Paidu Decoction may inhibit the Notch signaling transduction pathway by down-regulating the expressions of Notch1 and Jagged1,which plays a role in improving the renal interstitial fibrosis and protecting the kidney.关键词：renal fibrosis;Qinghua Gushen Paidu Decoction;unilateral ureteral obstruction(UUO);Notch1;Jagged1
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发布时间：2022-08-31 - 摘要：This paper systematically sorted out and elaborated the chemical components of Chaihu Shugan Powder and its pharmacological research in the treatment of depression,Alzheimer’s disease,nonalcoholic fatty liver disease and metabolism syndrome in recent 10 years. The main chemical components of Chaihu Shugan Powder include saponins,flavonoids,phenolic acids and terpenoids,and it shows multiple pharmacological effects,such as anti-depression,regulation of nerve-endocrine-immune network,anti-inflammation,anti-oxidative stress,lipid-lowering,hypoglycemic activity,anti-fibrosis and so on.关键词：Chaihu Shugan Powder;chemical components;pharmacological effects
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发布时间：2022-08-31 - 摘要：This article analyzed and compared the similarities and differences on chemical components,pharmacological effects and clinical application between natural bear bile and its artificial products or other animal bile. Research found that the contents of conjugated bile acids including tauroursodesoxycholic acid(TUDCA)and taurochenodeoxycholic acid(TCDCA)in artificially synthesized bear bile and its cholagogic,sedative and antibacterial effects were approximate to those of natural bear bile to some extent,which provided reference for searching alternative resources of natural bear bile.关键词：bear bile;bile acid;chemical components;pharmacological effects;clinical application;alternative resource
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发布时间：2022-08-31
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