最新刊期
期 8 ， 2017
- 摘要：Professor Shi Qi considers the pathogenesis of musculoskeletal diseases as “disharmony of qi-blood in zang-fu viscera and imbalance between muscles and bones”,and emphasizes the therapeutic principle of “regulating the balance”in clinic,which refers to regulating the balance between muscles and bones to restore the solid skeleton and pliable tendons and promote the flow of qi-blood. He creates the clinical guiding principle of“qi and blood as basis,both Zang and Fu,muscles and bones in combination”,and establishes the theoretical and therapeutic research system of musculoskeletal diseases,and founds a series of prevention and treatment methods for degenerative musculoskeletal diseases,forms a series of manipulation and exercise of regulating the balance between muscles and bones. These treatments are widely used in the clinical rehabilitation of cervical spondylosis,adolescent idiopathic scoliosis and other diseases.关键词：theory of bones and muscles;regulating muscles and bones;rehabilitation of orthopedics and traumatology
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发布时间：2022-08-31 - 摘要：This paper discussed the syndrome and treatment of belching due to depression syndrome. Belching is not only the manifestation of spleen-stomach disease, but also the manifestation of liver disease, heart disease or other simple depression syndrome. Belching due to depression syndrome is induced by bad emotions, with characteristics of belching loudly, being controlled by self-consciousness and feeling comfortable after belching. Belching accompanied by other symptoms of spleen and stomach, mainly belongs to the coexistence of diseases and depression syndrome of liver-stomach disharmony, which needs to be treated on both diseases and depression. Belching accompanied by manifestation of liver qi stagnation or deficiency of heart-qi, mainly belongs to simple depression syndrome, which needs to be only treated on depression in clinic. Thus, the treatment of belching is far from promoting digestion and harmonizing stomach and descending adverse qi. The theory and practice of ancient Chinese medicine on the syndrome and therapy of belching due to depression syndrome have got more and more support from modern medicine.关键词：depression syndrome;belching;liver-qi attacking stomach
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发布时间：2022-08-31 - 摘要：There are significant differences on the constitutional status between children and adults due to the special physiological and pathological characteristics. The common status of biased constitution include qi deficiency,yang deficiency,phlegm dampness,stagnation,liver fire,predominant heat,hypersensitivity and cowardice. And it also expounds the definition description,main manifestation,unhealthy tendency and mechanism explanation. It is considered that the research development of children constitution is of positive significance for the prevention and treatment of diseases and the maintenance of their normal growth and development.关键词：constitution;children;sub-health state
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发布时间：2022-08-31 - 摘要：Objective:To study the characteristics of mice model with deficiency syndrome induced by hydrocortisone and the potential material base. Methods 60 male Kunming mice were randomly divided into the normal control group and model group,30 mice in each group. The mice in the normal control group were treated with normal water and feeding,and the mice in the model group were treated with hydrocortisone solution with degressive dose(0.015 g·kg-1·d-1 for 3 days,0.010 g·kg-1·d-1 for 5 days and 0.007 5 g·kg-1·d-1 for 7 days). On the eighth and fifteenth day,the syndrome classification of mice was determined by standard acquisition technique and syndrome differentiation methods for the four methods of diagnosis in mice that created by our research group. On the third,eighth and fifteenth day,the mice were sacrificed respectively. The adrenal gland was collected and the RNA and protein were extracted. The expressions of related genes were detected by real time fluorescent quantitative PCR,the expression of steroidogenic acute regulatory protein(STAR) was detected by Western blotting,and the content of serum adrenocorticotropic hormone (ACTH) was measured by ELISA. Results: ①Compared with the normal control group,the body weight of the mice in the model group was significantly decreased during the modeling period(P<0.05),and the appearance such as marasmus,fluffy hair falling,decreased glossiness of hair,reduced activity with curled posture were observed,the temperature especially in the tail was decreased,but there was no obvious change on the claw color. ②Compared with the normal control group on the fifteenth day,the mice in the model group showed obvious syndrome of qi deficiency and yin deficiency,the persistent atrophy of adrenal gland,spleen and thymus were observed(P<0.05). The serum level of ATCH was decreased in the model group(P<0.05),the gene expressions of Srb1 and Ldlr as the important receptor in adrenocortical hormone synthesis were decreased(P<0.01),the gene expressions of steroid hormone synthases such as Star,Cyp11a1,Cyp21a1,Cyp11b1,Cyp11b2 and their transcription factors such as Fdx1,Fdxr,Nr4a1,Nr4a2 and Nr5a1 were significantly decreased (P<0.05), and the protein expression level of StAR was significantly decreased(P<0.01). Conclusion: Hydrocortisone can be used to induce the mice model with deficiency syndrome,which shows the characteristics of syndrome of qi deficiency and yin deficiency. The important functional molecules in the adrenocortical hormone synthesis are associated with the related syndrome.关键词：syndrome;deficiency syndrome;disease model;mice;hydrocortisone;adrenocortical function
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发布时间：2022-08-31 - 摘要：This paper summarizes Professor Yuan Hongxia’s commonly used prescriptions and combined prescriptions in clinical differentiation and treatment of stomachache,and the common syndrome patterns of stomachache are revealed by means of evaluating syndrome by prescription. And through the analysis of prescription and syndrome of stomachache,it reveals that the syndrome differentiation of prescription should follow the principle of prescriptions corresponding to syndrome. The application of harmonizing method in the differentiation and treatment of stomachache is also summarized.关键词：stomachache;syndrome differentiation of prescription;combined prescription;harmonizing method
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发布时间：2022-08-31 - 摘要：This paper introduced Professor Zheng Xiaowei’s experience in treating coughing variant asthma. He considers the wind pathogen as major pathogenic factors,and puts forward that invasion of wind pathogen and lung impairment of dispersing and descending are the key to this disease and deficiency of vital qi and stagnation of toxic pathogen are the nature of this disease. In the treatment,it should pay attention to the differentiation of root,manifestation,deficiency and excess and emphasize the treatment by stages. The comprehensive therapy of oral administration of Chinese medicine combined with acupoint application is used for syndrome differentiation and treatment.关键词：cough variant asthma;clinical experience;Zheng Xiaowei
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发布时间：2022-08-31 - 摘要：This paper introduced Professor Xu Hua’s experience in treating children’s common diseases with external treatment of Chinese medicine. She emphasizes that good physician should not neglect the external treatment,and summarizes the five advantages of external treatment of Chinese medicine. She creates Tuire Powder for the treatment of exogenous febrile disease in children and Xiaodian Decoction with external washing for the treatment of allergic purpura. And she makes good use of infantile massage in the treatment of children’s common spleen and stomach diseases.关键词：children’s common diseases;external treatment of Chinese medicine;clinical experience;Xu Hua
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发布时间：2022-08-31 - 摘要：This paper introduced Zhang Tingting’s clinical experience in treating endometriosis with therapy of clearing heat for removing blood stasis and dredging collaterals with pungent and warm-natured drugs. She considers the blood stasis blocking in uterus and Chong and Conception Channels as basic pathogenesis of this disease. In treatment,it should pay attention to the principles of disease and syndrome combination,deficiency and excess differentiation and treatment in accordance with seasonal conditions. The therapy of clearing blood stasis and warming and dredging,simultaneous application of warm and cold-natured drugs and reinforcement and elimination in combination are often used. And one proven case was presented.关键词：endometriosis;ovarian cysts;clearing heat for removing blood stasis;dredging collaterals with pungent and warm-natured drugs;therapy of traditional Chinese medicine
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发布时间：2022-08-31 - 摘要：This paper discussed the ideas of clinical application of classical prescriptions from three proven cases. It considers that the clinical prescription should follow the “prescription-disease-patient” triangle patterns of diagnosis and treatment,and the selection and application of classical prescriptions should base on constitution,classical prescription and syndrome and disease spectrum of classical prescriptions.关键词：prescription-disease-patient;classical prescription;clinical experience
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发布时间：2022-08-31 - 摘要：This paper introduced the clinical experience of Guizhi Fuling Pill in the treatment of chronic obstructive pulmonary diseases. It considers that the diseases are caused by phlegm and blood stasis obstructing lung and lung impairment of dispersing and descending. Guizhi Fuling Pill can promote blood circulation for removing blood stasis by dispersing and regulating qi movement,warming and dredging meridians,invigorating spleen for eliminating phlegm,astringing yin and clearing heat. One proven case was presented.关键词：chronic obstructive pulmonary diseases;Guizhi Fuling Pill;experience
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发布时间：2022-08-31 - 摘要：Based on Guide to Clinical Practice with Medical Records,this paper analyzes and summarizes Ye Tianshi’s thoughts of preserving stomach yin. His theory of stomach yin advocates the divided treatment of spleen and stomach,and pays attention to the preservation of stomach fluid. During the preservation of stomach yin,it also needs to protect stomach qi and stomach yang. On this basis,the concrete reflection of Ye Tianshi’s theory of stomach yin in the treatment and medication are summarized. The commonly used treatment methods include the therapy of clearing fire and moistening stomach,therapy of increasing fluid and moistening dryness,therapy of invigorating liver and regulating stomach and therapy of moistening stomach and benefiting lung.关键词：Ye Tianshi;stomach yin;Guide to Clinical Practice with Medical Records
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发布时间：2022-08-31 - 摘要：The concept of essential blood is rarely discussed in the early medical books. Through the analysis on the related concepts such as essence and essential qi,it considers that essential blood can be used as the basic concept of describing the attribute of living substances. From the discussion in later medical books,essential blood is originally a general term for essence and blood,especially the combined term of reproductive essence of male and female. Further,it is considered as the material basis for life activities,which goes deep into the nature of the concept of essential blood.关键词：essence;essential qi;essential blood
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发布时间：2022-08-31 - 摘要：By sorting out the ancient books and literatures of Chinese medicine in Ming and Qing Dynasties,this paper further discussed the disease name,etiology and pathogenesis and treatment medication of insomnia. From the recognition evolution of insomnia syndrome in Chinese medicine,it was arisen from the pre Qin and Han Dynasties,developed in the period of Song,Jin and Yuan Dynasties and improved in the Ming and Qing Dynasties. Many physicians in Ming and Qing Dynasties learned the medical experience of predecessors and wrote a large number of medical books combined with individual clinical practice,which made the understanding of insomnia syndrome more systematic and perfect.关键词：Ming and Qing Dynasties;insomnia syndrome;differentiation and treatment
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发布时间：2022-08-31 - 摘要：Objective:To observe the clinical efficacy of Xinjia Shengjiang Decoction combined with western medicine in treating patients of acute exacerbation of chronic obstructive pulmonary disease(AECOPD)with syndrome of phlegm-heat obstructing lung. Methods 104 AECOPD patients with syndrome of phlegm-heat obstructing lung were randomly divided into the treatment group and control group,52 cases in each group. The control group was treated with routine therapy of western medicine,and the treatment group was additionally treated with Xinjia Shengjiang Decoction based on the treatment for the control group,with a course of 14 days. The clinical efficacy was observed,and the changes of TCM syndrome score,COPD assessment test(CAT)scale score,6 minutes walk distance(6MWD) and related indexes of pulmonary ventilation function(forced expiratory volume in one second and forced vital capacity )were compared. Results: ①At the end of trial,a total of 100 cases completed the trial,and 50 cases in each group. ②The clinical total effective rate was 78.00% in the treatment group and 62.00% in the control group. The clinical efficacy of the treatment group was significantly better than that of the control group(P<0.05).③For the comparison between the two groups on 3rd,7th and 14th day respectively,there were statistically significant differences on the TCM syndrome score,CAT score and 6MWD. The decrease of TCM syndrome score and CAT score in the treatment group were more significant than those in the control group,and the increase of 6MWD in the treatment group was more significant than that in the control group(P<0.05).④For the comparison between treatment before and after treatment for 3,7,14 days respectively,there were statistically significant differences on the levels of FEV1/FVC% and FEV1% in both groups(P<0.05). There were no statistically significant differences on the levels of FEV1/FVC% and FEV1% between the two groups on 3rd,7th and 14th day(P>0.05). Conclusion: Xinjia Shengjiang Decoction combined with western medicine shows good efficacy in treating patients of acute exacerbation of chronic obstructive pulmonary disease with syndrome of phlegm-heat obstructing lung,which can significantly improve the life quality and exercise ability of patients.关键词：chronic obstructive pulmonary disease;lung distension;syndrome of phlegm-heat obstructing lung;Shengjiang Powder;Tiandi Shengjiang Decoction;Sanniu Decoction;lung and large intestine being interior-exteriorly related
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发布时间：2022-08-31 - 摘要：Objective:To observe the efficacy of Zhuyu Quzhuo Decoction in the treatment of stable angina pectoris of coronary heart disease combined with hyperlipidemia and the effect on the level of lipoprotein associated phospholipase A2(Lp-PLA2). Methods 110 patients were randomly divided into the control group and observation group,55 cases in each group. The control group was treated with routine therapy of western medicine,and the observation group was treated with Zhuyu Quzhuo Decoction based on the treatment for the control group,with a course of 12 weeks. The efficacy on electrocardiogram,the levels of blood lipid,hemorheological indexes and Lp-PLA2 in both groups were compared. Results: The total effective rate was 78.18% in the observation group and 54.55% in the control group. The efficacy of the observation group was better than that of the control group(P<0.05). After treatment,the levels of LDL-C,TC and TG in both groups were decreased(P<0.05),and the HDL-C level was increased(P<0.05). The improvement on blood lipid levels in the observation group was better than that in the control group(P<0.05). After treatment,the levels of hemorheological indexes,ADP and Lp-PLA2 in both groups were obviously decreased compared with treatment before(P<0.05),and the levels of all indicators in the observation group were lower than those in the control group(P<0.05). Conclusion: Zhuyu Quzhuo Decoction shows good clinical efficacy in the treatment of stable angina pectoris of coronary heart disease combined with hyperlipidemia,which can improve the blood lipid and hemorheology and decrease the levels of ADP and Lp-PLA2.关键词：stable angina pectoris of coronary heart disease;hyperlipidemia;Zhuyu Quzhuo Decoction;lipoprotein associated phospholipase A;2;(Lp-PLA;)
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发布时间：2022-08-31 - 摘要：Objective:To observe the clinical efficacy of Quyu Shengxin Formula combined with mesalazine in treating mild to moderate ulcerative colitis(UC). Methods 72 patients with mild to moderate ulcerative colitis were randomly divided into the treatment group and control group,36 cases in each group. The treatment group was treated with Quyu Shengxin Formula and mesalazine,and the control group was only treated with mesalazine,with a course of one month. The clinical efficacy was observed,and the changes of modified Mayo score,life quality scores of UC and the levels of related biochemical indexes including C reactive protein (CRP) and erythrocyte sedimentation rate (ESR) were compared. Results: ①During the trial,one case in the treatment group fell off due to loss to follow-up,and finally 36 cases in the control group and 35 cases in the treatment group completed the trial.②The clinical total effective rate was 88.57% in the treatment group and 75.00% in the control group. The clinical efficacy of the treatment group was significantly better than that of the control group(P<0.05). ③For the comparison between treatment before and after,there was statistically significant difference on the modified Mayo score in both groups,and the modified Mayo score was significantly decreased in both groups after treatment(P<0.05).For the comparison of the difference of treatment before and after,the difference of the modified Mayo score in the treatment was obviously greater than that in the control group(P<0.05).④For the comparison between the two groups after treatment,there were statistically significant differences on the life quality scores of UC(intestinal symptoms and systemic symptoms),the scores of the treatment group were obviously higher than those of the control group(P<0.05).⑤For the comparison between the two groups after treatment,there were statistically significant differences on the levels of CRP and ESR,the levels of the treatment group were obviously lower than those of the control group(P<0.05). Conclusion: Quyu Shengxin Formula combined with mesalazine can be used in the treatment of mild to moderate ulcerative colitis,which can significantly relieve the clinical symptoms in active stage,suppress the inflammatory reaction and improve the life quality of patients.关键词：ulcerative colitis;mesalazine;Quyu Shengxin Formula;tonifying deficiency and removing blood stasis and promoting granulation
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发布时间：2022-08-31 - 摘要：Objective:To observe the clinical efficacy of Compound Shenlu Granule combined with western medicine in the treatment of aplastic anemia(AA) with syndrome of kidney yang deficiency,and discuss its mechanism. Methods Sixty AA patients with syndrome of kidney yang deficiency were randomly divided into the treatment group and control group,30 cases in each group. The treatment group was treated with Compound Shenlu Granule combined with routine therapy of western medicine,while the control group was only treated with routine therapy of western medicine. The treatment course in both groups was 6 months with follow-up for one year. The clinical efficacy was observed,and the expression levels of Treg and Th17 in peripheral blood and the mRNA expressions of related gene transcription factors including retinoid related orphan nuclear receptor γt(RORγt)and forkhead transcription factor(Foxp3)were compared. Results: ①The clinical total effective rate was 76.67% in the treatment group and 63.33% in the control group. The clinical efficacy of treatment group was significantly better than that of control group (P<0.05). ②After treatment,there was no statistically significant difference on the expression level of Th17 between the two groups(P>0.05),while there were statistically significant differences on the Treg expression and Treg/Th17 level between the two groups,and the levels of the treatment group were obviously higher than those of the control group(P<0.05). ③After treatment,there was no statistically significant difference on the RORγt mRNA expression between the two groups(P>0.05),while there were statistically significant differences on Foxp3 mRNA expression and the Foxp3/ RORγt level between the two groups,and the levels of the treatment group were obviously higher than those of the control group(P<0.05). Conclusion: Compound Shenlu Granule combined with western medicine can significantly improve the clinical symptoms of AA patients,and enhance the hematopoietic function. Its mechanism may be associated with up-regulation of Treg cells and Foxp3 mRNA expression and increase of Treg /Th17 ratio.关键词：aplastic anemia;Compound Shenlu Granule;warming kidney for nourishing marrow;regulatory T cells;helper T cell 17;gene transcription
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发布时间：2022-08-31 - 摘要：Objective:To observe the clinical efficacy of Sanhuang Capsule combined with Jinhuang Ointment in the treatment of acute gouty arthritis with syndrome of dampness-heat blockage. Methods 60 patients of acute gouty arthritis with syndrome of dampness-heat blockage were randomly divided into the treatment group and control group,30 cases in each group. The control group was orally treated with diclofenac sodium,and the treatment group was additionally treated with Sanhuang Capsule for oral administration and Jinhuang Ointment for external application based on the treatment for the control group,with a course of 10 days. The clinical efficacy was observed ,and the changes of TCM syndrome score,visual analogue scale(VAS)scores(pain and activity limitation),score of joint swelling and the levels of the related biochemical indexes including blood uric acid (BUA),erythrocyte sedimentation rate (ESR) and C reactive protein (CRP) were compared. Results: ①The clinical tota1 effective rate was 93.33％ in the treatment group and 70.00％ in the control group. The clinical efficacy of the treatment group was significantly better than that of the control group(P<0.05). ②After treatment,there was statistically significant difference on TCM syndrome score between the two groups,and the score of the treatment group was obviously lower than that of the control group(P<0.05). ③After treatment,there were statistically significant differences on the VAS scores of pain and activity limitation and the score of joint swelling between the two groups,and the scores of the treatment group were significantly lower than those of the control group(P<0.05). ④After treatment,there were statistically significant differences on the levels of BUA,ESR and CRP between the two groups,and the levels of the treatment group were significantly lower than those of the control group(P<0.05). Conclusion:Sanhuang Capsule with oral administration and Jinhuang Ointment with external application combined with western medicine can be used in the treatment of acute gouty arthritis with syndrome of dampness-heat blockage,which can significantly relieve the clinical symptoms and decrease the level of uric acid.关键词：gouty arthritis;syndrome of dampness-heat blockage;Sanhuang Capsule;Jinhuang Ointment;blood uric acid;joint swelling pain
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发布时间：2022-08-31 - 摘要：Objective:To observe the clinical efficacy of Yiqi Xiezhuo tea drink combined with routine therapy of uestern medicine in the treatment of chronic gout. Methods 60 patients with chronic gout were randomly divided into the control group and treatment group,30 cases in each group. The control group was treated with routine interventions of uestern medicine, and the treatment group was treated with Yiqi Xiezhuo tea drink in small doses at short intervals based on the treatment for the control group,with a course of 12 weeks. The clinical efficacy was observed,and the level of serum uric acid and the score of 6-point behavioral rating scale(BRS-6) were detected and compared. Results: The total effective rate was 93.3% in the treatment group and 70.0% in the control group. There was statistically significant difference on the clinical efficacy between the two groups(P<0.05).For the comparison between treatment before and after,there were statistically significant differences on the level of serum uric acid and the BRS-6 score for joint pain in both groups(P<0.05). For the comparison after treatment,there were statistically significant differences on the level of serum uric acid and the BRS-6 score for joint pain between the two groups(P<0.05). Conclusion: The alimentary control and other general treatment show a certain efficacy in the treatment of chronic gout. On this basis,additional therapy of Yiqi Xiezhuo tea drink in small doses at short intervals can further reduce the level of serum uric acid,improve the joint pain of patients and enhance the overall efficacy.关键词：chronic gout;therapy of traditional Chinese medicine;Yiqi Xiezhuo drink
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发布时间：2022-08-31 - 摘要：Objective:To observe the clinical efficacy of comprehensive therapy of Chinese medicine in the treatment of senile sensorineural hearing loss. Methods Based on the randomized controlled trial,84 patients with senile sensorineural hearing loss were divided into the treatment group and control group, 42 cases in each group. The control group was orally treated with mecobalamin tablet,the treatment group was treated with comprehensive therapy of Chinese medicine including acupuncture,acupoint injection and ear acupoint plastering,with a course of 34 days. The clinical efficacy and medication safety were observed,the change of the mean of pure tone hearing threshold was compared,and the relationship between duration and efficacy was observed. Results: ①Finally 80 cases completed the trial,40 cases in each group. ②For the comparison between treatment before and after,there was statistically significant difference on the mean of pure tone hearing threshold in both groups(P<0.05).For the comparison of the difference of treatment before and after,there was statistically significant difference on the difference of the mean of pure tone hearing threshold between the two groups,and the improvement on the mean of pure tone hearing threshold in the treatment group was more significant than that in the control group(P<0.05). ③The clinical total effective rate was 82.50% in the treatment group and 62.50% in the control group. The clinical efficacy of the treatment group was significantly better than that of the control group(P<0.05). ④In the treatment group or control group respectively,the clinical efficacy on the patients with duration less than 3 years was significantly better than that on the patients with duration more than or equal to 3 years(P<0.05). For the patients with duration less than 3 years,the clinical total effective rate was 88.24% in the treatment group and 84.21% in the control group,and there was no statistically significant difference on the clinical efficacy between the two groups(P>0.05). For the patients with duration more than or equal to 3 years,the clinical total effective rate was 78.26% in the treatment group and 42.86% in the control group,and there was statistically significant difference on the clinical efficacy between the two groups(P<0.05). ⑤There was no statistically significant difference on the incidence of adverse reaction between the two groups(P>0.05). Conclusion: The comprehensive therapy of Chinese medicine shows good efficacy in the treatment of senile sensorineural hearing loss,which can significantly improve the hearing level of patients.关键词：sensorineural hearing loss;elderly people;comprehensive therapy;acupuncture;acupoint injection;ear acupoint plastering;pure tone hearing threshold;duration
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发布时间：2022-08-31 -
Discussion on prescription origin of Tongxie Yao Fang and the syndrome corresponding to prescription
摘要：By consulting the ancient books and modern works that related to Tongxie Yao Fang(important formula for painful diarrhea),this paper made the textual research and analysis on its prescription origin and the syndrome corresponding to prescription. It found that the original recipe originated from Danxi Xinfa(Danxi’s Mastery of Medicine)written by Zhu Danxi in Yuan Dynasty,and the name as Tongxie Yao Fang first appeared in Yifang Kao written by Wu Kun in Ming Dynasty. Wu Kun explained the pathogenesis of liver-yang hyperactivity and spleen deficiency in the treatment with Tongxie Yao Fang,which inherited by physicians in later generations. With the deepening understanding of later generations on Tongxie Yao Fang and Chinese medicine,there were many disputes around its prescription origin and the syndrome corresponding to prescription. This paper aimed to benefit the theoretical research and clinical application of Tongxie Yao Fang.关键词：Tongxie Yao Fang(important formula for painful diarrhea);prescription origin;syndrome corresponding to prescription;Danxi Xinfa(Danxi’s Mastery of Medicine);liver-yang hyperactivity and spleen deficiency- 5
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发布时间：2022-08-31 - 摘要：Objective:To establish the rat model of chronic obstructive pulmonary disease(COPD),investigate the mechanism of airway remodeling induced by imbalance of protease and protease inhibitors in COPD and study the effects and possible mechanism of Qinma Formula in the treatment of COPD. Methods 70 SPF rats were randomly divided into the normal group,model group,Qinma Formula groups with low-,middle- and high-dose,Liujunzi Decoction group and aminophylline group,10 rats in each group. Rat model of COPD was established by intratracheal injection of pyrosulfuryl chloride solution and mixture of lipopolysaccharide and pepsin combined with smoking. The respiratory function of rats was measured by noninvasive respiratory function apparatus. The morphology of lung tissue and bronchus were observed under light microscope. The serum content of transforming growth factor-β1 (TGF-β1) was detected by ELISA. The expressions of matrix metalloproteinases-9(MMP-9)and tissue inhibitor of metalloproteinnase-1(TIMP-1)in lung tissue were determined by immunohistochemistry. Results: Compared with the model group,Qima Formula could significantly decrease the respiratory frequency(P<0.05),and increase the respiratory flow(P<0.05). The thickness of airway wall and smooth muscle were significantly decreased in the Qinma Formula groups with middle-and high-dose(P<0.05).The serum content of TGF-β1 was significantly decreased in the Qinma Formula groups with low-,middle- and high-dose(P<0.05).The expressions of MMP-9 and TIMP-1 were significantly decreased in the Qinma Formula groups with middle- and high-dose(P<0.05). Conclusion: Qinma Formula could significantly improve the respiratory function of rats and down-regulate the expressions of MMP-9 and TGF-β1 in lung tissue,and thus reduce the destruction on alveolar and tracheal structures and reverse the airway remodeling.关键词：Qinma Formula;chronic obstructive pulmonary disease;airway remodeling;TGF-β;1;MMP-9;TIMP-1
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发布时间：2022-08-31 - 摘要：Objective:To investigate the preventive effects of taxifolin on CCl4-induced acute liver injury in rats and its possible mechanism based on metabonomic. Methods A total of 30 Wistar rats were randomly divided into the normal group,model group and taxifolin group,10 rats in each group. The normal group and model group were treated with 0.5% CMC-Na solution for intragastric administration,and the taxifolin group was treated with taxifolin at daily dose of 150 μg/g for intragastric administration,with a course of continuous 14 days. 2 hours after the last administration, the model group and taxifolin group were treated with CCl4 for intraperitoneal injection to induce the acute liver injury. 24 hours after modeling,the blood and liver tissue were collected and the liver index was calculated. The serum levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST),the activity of superoxide dismutase (SOD) and content of malondialdehyde (MDA) in liver tissue were detected,and the histopathological changes of liver were observed. The changes of metabolic spectrum were analyzed by liquid chromatography-mass spectrometry (LC/MS), and the differential metabolites were identified. Results: Compared with the normal group,the liver index was increased in the model group(P<0.01),and the levels of ALT and AST were increased(P<0.01),the activity of SOD was decreased(P<0.01)and the content of MDA was increased(P<0.05),the obvious liver injury was observed. Compared with the model group,the liver index was decreased in the taxifolin group(P<0.01),and the levels of ALT and AST were decreased(P<0.01),the activity of SOD was increased and the content of MDA was decreased(P<0.05),the damage degree of liver tissue was improved. Compared with the normal group,there were 12 kinds of differential metabolites in the model group,including taurocholic acid,cholic acid,deoxycholic acid,threonine,pyroglutamic acid,glutamine,phosphatidyl ethanolamine(PE)(16:0),docosapentenoic acid,PE(18:1),PE(18:2),phosphatidyl serine(PS)(18:1) and PS(18:2). After the treatment with taxifolin,these metabolites showed the callback trend. Conclusion: Taxifolin shows protective effects on CCl4-induced chemical liver injury,its mechanism may be associated with inhibition of lipid peroxidation and regulation of bile acid metabolism,amino acid metabolism,fatty acid metabolism and glycerol phospholipid metabolism disorder.
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发布时间：2022-08-31 - 摘要：Objective:To evaluate the effects of five kinds extracts of deer antler base on the immunological function in H22 tumor bearing mice. Methods A total of 90 SPF Kunming mice were randomly divided into the normal control group,model group,positive control group,group of original powder of deer antler base and groups of 5 kinds extracts of deer antler base that treated with acid,base,salt,alcohol and water respectively,10 mice in each group. By the pathological changes of spleen,the percentage of T-lymphocyte subsets CD4+ and CD8+ in peripheral blood and spleen and the serum levels of cytokines(IL-6,IL-12)and antibody(IgE,IgG,IgM),the effects of five kinds extracts of deer antler base which extracted by hydrochloric acid,sodium hydroxide,sodium chloride,ethanol and water on the immunological function in tumor bearing mice were evaluated. Results: Compared with the model group,the 5 kinds extracts of deer antler base could protect the spleen structure of tumor-bearing mice,improve the ratio of CD4+/CD8+ in spleen and peripheral blood(P<0.05),and increase the serum levels of IL-6,IL-12 and IgE,IgG,IgM(P<0.05). Conclusion: The alkaline solution extract of deer antler base shows the best effects. Deer antler base may play the antitumor role by improving the humoral and cellular immunity of tumor bearing mice and reversing the inhibition on immunological function caused by tumor.关键词：deer antler base;H;22;tumor bearing mice;immunological function;cytokines;immunoglobulin
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- 125
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发布时间：2022-08-31 - 摘要：Objective:To study the effects of drug-containing serum of Suoquan Pill on proliferation and differentiation of mouse embryonic stem cells(ESCs)and Nanog gene expression. Methods The embryonic stem cell line derived from 129 mice was selected. The cultured cells were divided into the blank group,Jingui Shenqi Pill group,Suoquan Pill groups with low-,middle- and high-dose. The blank group was treated with blank serum of rats at concentration of 10%,the Jingui Shenqi Pill group was treated with the drug-containing serum at concentration of 10%. The drug-containing serum of Suoquan Pill was obtained from rats that treated with Suoquan Pill for intragastric administration at daily dose of 0.585,1.17 and 2.34 g·kg-1·d-1 respectively. The Suoquan Pill groups with low-,middle-and high-dose were treated with the corresponding drug-containing serum at concentration of 10%. The effect of Suoquan Pill on ESCs proliferation was detected by flow cytometry. The effect of drug-containing serum of Suoquan Pill on differentiation of DMSO induced ESCs was observed by inverted phase contrast microscope. The Nanog mRNA expression in ESCs was detected by fluorescent quantitative PCR and the Nanog protein expression was detected by flow cytometry. Results: Compared with the blank group,the drug-containing serum of Suoquan Pill with middle-and high-dose could promote ESCs proliferation(P<0.01),the drug-containing serum of Suoquan Pill with low-and high-dose could significantly increase Nanog mRNA expression in ESCs(P<0.05,P<0.01),and the drug-containing serum of Suoquan Pill with middle-and high-dose could significantly up-regulate Nanog protein expression in ESCs(P<0.05,P<0.01). Compared with the blank group,the drug-containing serum of Suoquan Pill with high-dose could promote the differentiation of DMSO induced ESCs. Conclusion: Suoquan Pill can promote ESCs proliferation and differentiation of DMSO induced ESCs,which may be associated with the up-regulation of Nanog expression.关键词：Suoquan Pill;serum pharmacology;embryonic stem cells;Nanog
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发布时间：2022-08-31 - 摘要：Objective:To establish the perfect quality standard for hospital pharmaceutical preparation and improve the controllability and stability of Xuetong Capsule. Methods From the qualitative and quantitative analysis,the qualitative identification of three kinds of Chinese materia medica including Radix Polygoni Multiflori,Hirudo and Radix et Rhizoma Rhei in Xuetong Capsule was performed by thin-layer chromatography,and the content determination of tetrahydroxystilbene glucoside in Radix Polygoni Multiflori was performed by high performance liquid chromatography. Results: The three medicinal materials show the clear spots in thin layer chromatography with specificity. There is good linearity on the calibration curve of tetrahydroxystilbene glucoside,and the detection results of accuracy,repeatability,stability and recovery rate meet the requirement. Conclusion: The method is accurate and reliable for qualitative and quantitative detection,which can effectively control the quality of Xuetong Capsule.关键词：Xuetong Capsule;quality standard;thin-layer chromatography;high performance liquid chromatography
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- 150
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发布时间：2022-08-31 - 摘要：This paper reviewed the clinical efficacy and mechanism research of Zexie Decoction in the treatment of essential hypertension. Zexie Decoction shows definite clinical efficacy in the treatment of essential hypertension. Its mechanism of anti-hypertension is mainly associated with the regulation of renin-angiotensin-aldosterone system(RAAS),protection of vascular endothelium,inhibition of vascular remodeling,regulation of K+ and Na+ pumps,potassium sparing diuresis,improvement of insulin resistance,which plays the safe and stable role of anti-hypertension with multi mechanism and targets.关键词：Zexie Decoction;clinical efficacy;mechanism research;review
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- 415
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发布时间：2022-08-31 - 摘要：This paper reviewed the research progress on the pharmacological activities of Fructus Ligustri Lucidi. Fructus Ligustri Lucidi shows the multiple pharmacological activities such as anti-tumor,hepatoprotection,anti-oxidation,anti-inflammation,hypoglycemic effect,lipid-lowering,immune regulation,anti-bacteria,anti-virus and anti-osteoporosis,which presents significant efficacy in the prevention and treatment of cancer,diabetes,hepatitis and other diseases.关键词：Fructus Ligustri Lucidi;pharmacological activities;research progress
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发布时间：2022-08-31 - 摘要：The incidence of recurrent spontaneous abortion has increased year by year,but the clinical treatment methods are limited. In recent years,it has found that thrombophilia is closely related to recurrent spontaneous abortion,which may be a new way for treatment. According to the close relationship between thrombophilia and syndrome of blood stasis,the treatment of Chinese medicine has also gradually changed the clinical traditional therapy of invigorating kidney and clearing heat,and paid attention to the treatment based on relieving blood stasis,which obtained good efficacy. Through the discussion on the relationship between syndrome of blood stasis and recurrent spontaneous abortion caused by thrombophilia,this paper summarizes the research progress on the therapy of promoting blood circulation for removing blood stasis in the treatment of recurrent spontaneous abortion,which aims to provide a new idea for the treatment of recurrent spontaneous abortion with Chinese medicine.关键词：recurrent spontaneous abortion;thrombophilia;therapy of promoting blood circulation for removing blood stasis;review
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发布时间：2022-08-31
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