最新刊期
期 7 ， 2017
- 摘要：This paper discussed Professor Shi Qi’s academic thoughts of prevention and treatment of bone metabolic diseases. Through the clinical and fundamental research,he considers the pathological basis of bone metabolic diseases as deficiency of kidney essence,imbalance of yin and yang and bone loss due to essence deficiency,and creates the therapy principle of invigorating kidney for nourishing essence and harmonizing kidney yin and yang, proposes a series of research programs,techniques and guidelines in clinic. He elaborates that the therapy of invigorating kidney for nourishing essence plays a role in the prevention and treatment of bone metabolic diseases through recovering the balance between osteoblast mediated bone formation and osteoclast mediated bone resorption and maintaining bone homeostasis,which are taken as the development of theory of “kidney governing bones”“kidney storing essence” and further expand the guiding role of theory of traditional Chinese medicine in clinical practice and fundamental research.关键词：bone metabolic diseases;osteoporosis;therapy of invigorating kidney for nourishing essence;experience of famous doctor;Shi Qi
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发布时间：2022-08-31 - 摘要：Acid regurgitation due to depression syndrome refers to acid reflux caused by the seven emotions directly and indirectly,which presents two manifestations as single depression syndrome or the coexistence of diseases and depression syndrome.The coexistence of diseases and depression syndrome refers to liver-stomach diseases and incoordination between liver and stomach,mainly including the syndromes of liver qi invading stomach and stagnated heat in liver and stomach. The single depression syndrome refers to the corresponding syndromes caused by liver and heart (spleen) impairment due to seven emotions.Acid regurgitation of single depression syndrome induced by liver diseases may present with a few manifestations in liver meridian,or various complex physical symptoms involving multiple organs.The latter mainly belongs to recessive depression syndrome or generalized depression syndrome.The six stagnation diseases are also considered as the common pathogenesis of acid regurgitation due to depression syndrome. Acid regurgitation due to depression syndrome can be identified by its clinical features.The treatment should base on relieving depression or adjunctive therapy for depression. Acid regurgitation due to depression syndrome can be seen in the diseases such as gastroesophageal reflux and functional dyspepsia,depression,anxiety and somatoform disorders,which caused by mental and psychological factors in modern medicine.关键词：depression syndrome;acid regurgitation;liver-stomach diseases;liver disease;six stagnation diseases
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发布时间：2022-08-31 - 摘要：Xia’s Chinese medical surgery,as a famous Shanghai style of traditional Chinese medicine,has formed the unique academic theory system and accumulated rich experience in clinical application after several generations of inheritance and development. This paper elaborated the theories of “expelling the pathogens nearby as early as possible,protecting yin fluid,blood heat making yang floating” in Xia’s Chinese medical surgery,and the influence of theory of epidemic febrile diseases on it. Combined with the proven cases and modern clinical research achievement,the application was also introduced.关键词：Xia’s Chinese medical surgery;schools of traditional Chinese medicine;science of epidemic febrile disease in traditional Chinese medicine
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发布时间：2022-08-31 - 摘要：Objective:To preliminarily explore the related biological basis of the theory of “intestinal diseases affecting lung”and treatment from lung in slow transit constipation(STC)by the changes of the lung and intestine pathology and the content of aquaporins(AQPs)based on compound diphenoxylate induced STC model. Methods20 SD rats were randomly divided into the normal group and model group,10 rats in each group with male and female in half. The normal group was fed with normal diet,and the model group was fed with diet containing compound diphenoxylate,with a course of 120 days. After modeling,the fecal amount within 24 hours,the water content in faeces and the rate of carbon propelling in small intestine of rats were measured,and the number of retained fecal particles in colon was observed. The pathological changes of lung and intestine were observed by HE staining. The expression levels of AQP1 in lung and AQP3 in intestinal tissue were determined by immunohistochemistry. Results:Compared with the normal group,the fecal amount within 24 hours,the water content in faeces,the rate of carbon propelling in small intestine and the number of retained fecal particles in colon were significantly decreased in the model group(P<0.01). The pathological changes of lung and intestine with different degrees in rats were found in the model group. The coloring amount and degree of AQP1 in lung and AQP3 in colon in the model group were higher than those in the normal group(P<0.01). Conclusion:The model of slow transit constipation is successfully replicated by compound diphenoxylate. The obvious pathological changes of lung and intestine are observed in the model rats,and the increasing contents of AQP1 in lung and AQP3 in intestine induce the disorder of body fluid metabolism,which may be the biological basis of the theory of “intestinal diseases affecting lung”and treatment from lung in slow transit constipation关键词：slow transit constipation;intestinal diseases affecting lung;treatment based on lung;rats;pathological changes;aquaporin
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发布时间：2022-08-31 - 摘要：This paper introduced Professor Lu Jin’gen’s clinical experience in the treatment of functional constipation in elderly. He considers that the elderly patients with functional constipation often manifest the syndrome of qi and yin deficiency,and the treatment should base on the therapy of benefiting qi,nourishing yin,clearing and removing. He proposes the Yiqi Kaimi prescription which modified according to the condition. Two proven cases were presented.关键词：elderly functional constipation;qi and yin deficiency;experience of famous physician;Lu Jin’gen
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发布时间：2022-08-31 - 摘要：This article introduced Professor Li Zhidao’s characteristic acupuncture manipulation in the treatment of peripheral facial paralysis,including“front-lateral and shallow-deep needling” that refers to“acupuncture in the middle sites first and both sides later,shallow neddling when slight symptoms and deep needling when severe symptoms”and “acupuncture manipulation for prevention of three symptoms” that refers to facial edema,facial spasm and facial paralysis. Two medical cases were presented.关键词：peripheral facial paralysis;acupuncture manipulation;needling sensation of qi arrival on double acupoints;experience of famous physician;Li Zhidao
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发布时间：2022-08-31 - 摘要：This paper discussed Professor Guo Jun’s experience in the differentiation and treatment of chordee. By analyzing the etiology and pathogenesis,he puts forward that the diseases can be classified into four syndrome patterns,including dampness-heat of liver and gallbladder,stagnation of liver qi,hyperactivity of yang due to yin deficiency,qi stagnation and blood stasis. He pays attention to the treatment based on liver,and emphasizes the combination of clearing liver-fire,dispersing stagnated liver qi and nourishing liver and reinforcement and elimination in combination. One proven case was presented.关键词：chordee;treatment based on liver;clinical experience;Guo Jun
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发布时间：2022-08-31 - 摘要：This paper introduced Tian Jianhui’s clinical experience in the differentiation and treatment of lung cancer associated with insomnia. He considers that lung cancer associated with insomnia are mainly caused by mental and psychological factors,adverse reactions of radiochemotherapy,cancer pain and so on. In clinic,it should pay attention to emotional therapy. According to the core pathogenesis,taken liver regulation as the core,the treatment should combine the disease differentiation with syndrome differentiation from the three aspects of deficiency syndrome,excess syndrome and miscellaneous syndrome. One proven case was presented.关键词：lung cancer;insomnia;clinical experience;Tian Jianhui
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发布时间：2022-08-31 - 摘要：This paper introduced Professor Huang Huang’s clinical experience in treating cervical cancer after radiochemotherapy with Zhuling Decoction. He considers that the clinical treatment should base on the principle of corresponding of prescriptions and syndromes and combination of syndrome and disease differentiation. In the diagnosis and treatment,he selects Zhuling Decoction with effects of eliminating dampness and diuresis and nourishing yin and clearing heat. One proven case was presented.关键词：cervical cancer;radioactive urethritis;radiochemotherapy;Zhuling Decoction;clinical experience;Huang Huang
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发布时间：2022-08-31 - 摘要：This paper investigated the origin and development of meridians differentiation. The study finds that the emergence and development of meridians differentiation has experienced a long period from pre Qin Dynasty to Ming and Qing Dynasties. The embryonic form of meridians differentiation emerged at book copied on silk in pre Qin Dynasty. The foundation of meridians differentiation was established in Qin and Han Dynasties classics,and the complete system associated with relationship among organ viscera,meridians and collaterals,meridians differentiation,collaterals differentiation,six meridians of foot was made. The acupoint indications and the theory of Eight Extraordinary Channels were further developed in the period of Wei,Jin and Southern and Northern Dynasties. During the Song,Jin and Yuan Dynasties,the flowering of all schools presented,and there were many breakthroughs in the theory of channel tropism,fourteen channels and others. Until Ming and Qing Dynasties,the theory of collaterals was further developed,which made the system of meridians differentiation more perfect.关键词：meridians;syndrome differentiation;acupuncture and moxibustion
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发布时间：2022-08-31 - 摘要：The understanding of “gallbladder controls the power of decision”in ancient and modern time is mainly confined to the important role that gallbladder plays in human mental and emotional activities,which seems too unilateral. So it’s necessary to re-understand“gallbladder controls the power of decision” by returning the literal meaning of the word “decision”. The substance of “gallbladder controls the power of decision”is that gallbladder stores,secretes and excretes bile,and decides the time and quantity of bile storage and discharge. The manifestation patterns of this kind of decision include regulating the storage and discharge of zang-fu organs, the transformation and metabolism of food and water, and the qi movement as well as qi and blood. Otherwise,the disorder and obstruction of bile storage and discharge could lead to difficult bile discharge or disproportionality of excretory ingredients,and subsequently affect the regulation of storage and discharge of zang-fu organs and finally result in systemic multiple system lesions. The physiological base of “gallbladder controls the power of decision” is the anatomical features of gallbladder,the ascription of zang-fu organs and its concurrent functional properties of storage and discharge.关键词：gallbladder;decision;storage and discharge;balance
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发布时间：2022-08-31 - 摘要：Objective:To observe the effects of Yupingfeng Granule on immune related indexes in children with bronchial asthma in remission stage. MethodsTwo hundred children patients with bronchial asthma in remission stage were randomly divided into the treatment group and control group,100 cases in each group. The control group was treated with montelukast sodium,and the treatment group was treated with Yupingfeng Granule and montelukast sodium,with a course of 2 months. The incidence of cough,fever and lower respiratory infection were observed during the follow-up period of 6 months. The changes of absolute counting of eosinophil (EOS) in peripheral blood,serum total immunoglobulin E (IgE) and inflammatory cytokines(IFN-γ,IL-13,IL-17,IL-9,IL-5)were compared. Results:①During the follow-up period of 6 months,the incidence of repeated cough,fever and lower respiratory infection in the treatment group were significantly less than those in the control group(P<0.05). ②After treatment,the EOS level of the treatment group was significantly lower than that of the control group(P<0.05). ③After treatment,the total IgE positive rate of the treatment group was significantly lower than that of the control group(P<0.05). ④There were statistically significant differences on the levels of IL-13,IL-17,IL-9 between the two groups after treatment,and the levels of the treatment group were significantly lower than those of the control group(P<0.05). Conclusion:Yupingfeng Granule can be used in the treatment of childhood asthma in remission stage,which significantly prolong the clinical remission period and reduce the cough recurrence and secondary infection. Its mechanism may be related to the inhibition of inflammatory cytokines and the function regulation of T cell subsets.关键词：childhood asthma;remission stage;Yupingfeng Granule;leukotriene receptor antagonist;inflammatory cytokines
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发布时间：2022-08-31 - 摘要：Objective:To observe the short term clinical efficacy of Shidao Tongjie Granule combined with chemotherapy in the treatment of advanced esophageal cancer. Methods80 patients with advanced esophageal cancer were randomly divided into the control group and treatment group, 40 cases in each group. The control group was treated with chemotherapy of paclitaxel and carboplatin,the treatment group was additionally treated with Shidao Tongjie Granule based on the treatment for the control group,with a course of 2 months. The short term efficacy was observed,and the changes of Chinese medical syndrome score,adverse reactions induced by chemotherapy and immune function indexes were compared. Results:①The clinical total effective rate was 55.00% in the treatment group and 32.50% in the control group. The short term efficacy in the treatment group was significantly better than that in the control group(P<0.05). ②There was statistically significant difference on the Chinese medical syndrome score between the two groups after treatment,and the Chinese medical syndrome score of the treatment group was significantly lower than that of the control group(P<0.05). ③During the treatment,the adverse reactions induced by chemotherapy including aleucocytosis,thrombocytopenia,anemia and pernicious vomiting were significantly improved in the treatment group compared with the control group(P<0.05). ④There were statistically significant differences on the levels of CD3+,CD4+,CD8+,CD4+/CD8+and NK cells between the two groups after treatment(P<0.05). Conclusion:Shidao Tongjie Granule can significantly enhance the short term efficacy in the treatment of advanced esophageal cancer,which improve the clinical symptoms,alleviate the adverse reactions induced by chemotherapy and regulate the immune function of patients.关键词：esophageal cancer;advanced stage;Shidao Tongjie Granule;chemotherapy;integrated Chinese and western medicine;reducing toxicity and enhancing efficacy
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发布时间：2022-08-31 - 摘要：Objective:To observe the influence of Yijinjing(changing tendon exercise)on motor function and life quality of convalescent patients with cerebral infarction. Methods60 convalescent patients with cerebral infarction were randomly divided into the treatment group and control group,30 cases in each group. The control group was treated with routine rehabilitation interventions,the treatment group was treated with exercises of Yijinjing based on the treatment for the control group,with a course of 21 days. The scores changes of Fugl-Meyer assessment(FMA)scale,improved Rankin Scale, Barthel index(BI)scale and quality of life(QOL)scale were observed. Results:For the comparison of treatment before and after,the scores of FMA scale,BI scale and QOL scale were all significantly increased in both groups(P<0.05),and the improved Rankin scale score was decreased in both groups(P<0.05).For the comparison after treatment,there were statistically significant differences on all the scale scores between the two groups(P<0.05). Conclusion:Based on the routine rehabilitation interventions,Yijinjing exercises can significantly improve the motor function of convalescent patients with cerebral infarction,promote the recovery of neurological function,enhance the ability of daily living and independent living levels.关键词：cerebral infarction;convalescence;rehabilitation;Yijinjing(changing tendon exercise)
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发布时间：2022-08-31 - 摘要：Objective:To observe the clinical efficacy of warming needle acupuncture on Jiaji acpoint(Ex-B2)combined with Shi’s twelve-word health maintenance exercise in the treatment of cervical spondylotic radiculopathy. Methods90 patients with cervical spondylotic radiculopathy were randomly divided into the treatment group and control group,45 cases in each group. The control group was orally treated with Jingtongling capsule,and the treatment group was treated with warming needle acupuncture on Jiaji acpoint combined with Shi’s twelve-word health maintenance exercise. The treatment course in both groups was 70 days with follow-up for 6 months. The clinical efficacy and the recurrence during follow-up were observed,and the changes of visual analog scales(VAS) score on cervical pain and neck disability index(NDI)were compared. Results:①The clinical total effective rate was 95.56% in the treatment group and 75.56% in the control group. The clinical efficacy of the treatment group was significantly better than that of the control group(P<0.05). ②For the comparison of the difference of treatment before and after,there was statistically significant difference on the VAS score difference between the two groups,and the improvement on VAS score in the treatment group was more significant than that in the control group(P<0.05). ③For the comparison of the difference of treatment before and after,there was statistically significant difference on the NDI difference between the two groups,and the improvement on NDI in the treatment group was more significant than that in the control group(P<0.05). ④For the comparison of the recurrence during follow-up,the recurrence rate of the treatment group was significantly lower than that of the control group(P<0.05). Conclusion:The warming needle acupuncture on Jiaji acpoint combined with Shi’s twelve-word health maintenance exercise can significantly alleviate the clinical symptoms of patients,restore the normal function of cervical vertebra.关键词：cervical spondylosis;radiculopathy;acupuncture;warming needle;exercise of traditional Chinese medicine;Shi Qi
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发布时间：2022-08-31 - 摘要：Objective:To observe the influence of oblique pulling method on soft tissue tension in patients with lumbar disc herniation(LDH). Methods120 patients were randomly divided into the group A(treatment with oblique pulling method on normal side),group B(treatment with oblique pulling method on affected side),group C(treatment with oblique pulling method on normal and affected sides)and group D(treatment without oblique pulling method).And the corresponding manipulation therapy was given in each group. The displacement values of soft tissue tension in lumbar normal and affected sides were detected and compared before and after treatment by soft tissue tension test system. Results:After the different intervention,the displacement values of soft tissue tension in normal and affected sides all showed the increasing tread in the four groups. Compared with treatment before,the displacement values of soft tissue tension in normal and affected sides were increased in group A,B and C after treatment,and the displacement value of soft tissue tension in affected sides was increased in group D after treatment(P<0.05). There were statistically significant differences on the displacement values of soft tissue tension between group B or C and group D after treatment(P<0.05). Conclusion:The tuina therapy of oblique pulling method can significantly improve the lumbar soft tissue tension in patients with lumbar disc herniation.关键词：lumbar disc herniation;oblique pulling method;soft tissue tension;tuina therapy
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发布时间：2022-08-31 - 摘要：Objective:To study the effects of Taohong Siwu Decoction on bone metabolism in patients with fracture of tibial plateau after fixation operation. Methods76 patients with fracture of tibial plateau were randomly divided into the control group and treatment group,38 cases in each group. All the patients were treated with internal and external double plate fixation. Meanwhile,the patients in the treatment group were treated with Taohong Siwu Decoction in addition,with a course of 28 days. The clinical efficacy was observed in both groups,and the changes of bone metabolism indexes were compared before and after treatment. Results:The clinical total effective rate was 97.37% in the treatment group and 81.59% in the control group. The clinical efficacy of the treatment group was better than that of the control group(P<0.05).Compare with treatment before,the serum levels of bone formation indexes including alkaline phosphatase (ALP),insulin-like growth factor I (IGF-I) and procollagen type I N-terminal propeptide (PINP) and the serum levels of bone metabolism indexes including matrix metalloproteinase-1 (MMP-1),matrix metalloproteinase-2 (MMP-2) and collagen type I cross-linked C-terminal peptide (sCTx) were increased in both groups after treatment (P<0.05),and the levels in the treatment group were all higher than those in the control group(P<0.05). Conclusion:Taohong Siwu Decoction can significantly improve the knee joint function and bone metabolism in patients with fracture of tibial plateau after fixation operation,which promote the fracture healing.关键词：fracture of tibial plateau;Taohong Siwu Decoction;fixation operation;bone metabolism
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发布时间：2022-08-31 - 摘要：Objective:To observe the clinical efficacy of Zizhu Ointment with external application in the treatment of venous ulcer in lower limb. Methods60 patients of venous ulcer in lower limb were randomly divided into the treatment group and control group,30 cases in each group. The treatment group was treated with Zizhu Ointment for external application,and the control group was treated with spray of recombinant bovine basic fibroblast growth factor and ethacridine lactate solution for moisten compress,with a course of 100 days. The clinical efficacy was observed,and the ulcer area,the maximum diameter and the healing time were compared. Results:①The clinical total effective rate of the treatment group and the control group were 96.67% and 83.33% respectively,and the clinical efficacy of the treatment group was significantly better than that of the control group(P<0.05).②For the comparison between the two groups after treatment,the decrease of ulcer area and maximum diameter in the treatment group were more significant than those in the control group(P<0.05). ③During the trial,the healing time of ulcer in the treatment group was significantly shorter than that in the control group(P<0.05). Conclusion:Zizhu Ointment with external application can be used in the treatment of venous ulcer in lower limb,which significantly improve the wound environment,enhance the cure rate and shorten the course of disease.关键词：venous ulcer in lower limb;ecthyma;Zizhu Ointment;ulcer area;healing time;Xi Jiuyi
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发布时间：2022-08-31 - 摘要：Objective:To observe the clinical efficacy of acupoint massage with plant essential oil in the treatment of chronic prostatitis. Methods70 patients with chronic prostatitis were randomly divided into the treatment group and control group,35 cases in each group. Based on the oral medication of modified Sanren Decoction,the treatment group was treated with acupoint massage with plant essential oil and the control group was treated with acupoint massage with apricot kernel oil as placebo in addition,with a course of one month. The clinical efficacy was observed,and the changes of total score of chronic prostatitis symptom index (NIH-CPSI) and white blood cell count in prostatic fluid were compared. Results:①The clinical total effective rate was 53.13% in the treatment group and 23.53% in the control group. The clinical efficacy of the treatment group was significantly better than that of the control group(P<0.05).②After treatment,the total score of NIH-CPSI in the treatment group was significantly lower than that in the control group(P<0.05).③After treatment,there was no statistically significant difference on the grade of white blood cell count in prostatic fluid between the two groups(P>0.05). Conclusion:Acupoint massage with plant essential oil combined with Chinese medicine shows good efficacy in the treatment of chronic prostatitis,which can significantly alleviate the clinical symptoms of patients and is safe and feasible.关键词：chronic prostatitis;plant essential oil;acupoint massage;aromatherapy
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发布时间：2022-08-31 - 摘要：From the therapy of eliminating pathogenic factors in the treatment of exogenous diseases,this paper analyzed the prescription significance and efficacy characteristics of Shengjiang Powder,explicated its application and the related pathogenesis. It reflects that the therapy idea of eliminating pathogenic factors from multi orifices is the application model of “exogenous pathogenic factors invading into and dispelling out from orifices”. It emphasizes the rising and falling of qi movement and takes clearing heat as main with cold and warm in combination, and forms the compatibility characteristics of interaction.关键词：febrile disease;Shengjiang Powder;eliminating pathogenic factors;out from orifices
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发布时间：2022-08-31 - 摘要：Objective:To study the regulation of matrine on Th1/Th2 mechanism of Pseudomonas aeruginosa(PA)infected lung in rats. Methods40 SD rats of clean grade were randomly divided into the normal control group,PA model group,matrine group,levofloxacin group and combination group,8 rats in each group. After anaesthesia,the model was established by PA injection with bronchial intubation,while the normal control group was treated with normal saline instead of PA. Each group was treated with the corresponding intervention. The pathological changes of lung tissue were observed. The contents of interleukin-4(IL-4) and interferon-γ(IFN-γ) in lung tissue were detected by ELISA,the protein expressions of T-bet and Gata-3 were determined by Western blot,and the mRNA expressions of IL-4,IFN-γ,T-bet and Gata-3 were detected by semi-quantitative RT-PCR. Results:Compared with the PA model group,the content and mRNA expression of IL-4 in lung tissue were decreased in the matrine group,levofloxacin group and combination group,while the content and mRNA expression of IFN-γ were increased(P<0.05). Compared with the PA model group,the protein and mRNA expressions of Gata-3 in lung tissue were decreased in the matrine group,levofloxacin group and combination group(P<0.05),while the protein and mRNA expressions of T-bet were increased(P<0.05). Conclusion:Matrine can regulate the expressions of transcription factor T-bet and Gata-3 in lung of rats with Pseudomonas aeruginosa infection,induce the differentiation from Th2 to Th1,promote IFN-γ synthesis and inhibit IL-4 synthesis,and thus reduce the pathological infection of lung.关键词：matrine;Pseudomonas aeruginosa;pulmonary infection;T-bet;Gata-3;IL-4;IFN-γ
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发布时间：2022-08-31 - 摘要：Objective:To study the protective effects of cinnamon on liver injury in diabetic rats. MethodsThe rats were randomly divided into the normal group and modeling group. Before modeling the rats were fasted for 12 hours but water was taken freely. Then the diabetes model was established in the modeling group by intraperitoneal injection of streptozotocin (STZ) at dose of 85 μg/g. Three days later,the rats with fasting blood glucose (FBG) value above 16.7 mmol/L were randomly divided into the model group and cinnamon group (1.5 g/kg). After administration for 25 days,the FBG of rats was measured,the body weight was recorded and the liver index was calculated. The serum activity of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) and serum content of total protein (TP) and albumin (ALB) were detected. The serum activity of superoxide dismutase (T-SOD) and serum content of malondialdehyde (MDA) in rats were determined by hydroxylamine method and DTNB method,respectively. The levels of energy products in liver tissue including phosphocreatine (PCr),adenosine triphosphate (ATP),adenosine diphosphate (ADP) and adenosine monophosphate (AMP) were detected by high performance liquid chromatography. Results:Compared with the normal group,the blood glucose levels,liver index,serum levels of ALT, AST and MDA were significantly increased in the model group,and the body weight,serum contents of TP and ALB,serum activity of T-SOD and the levels of PCr and ATP in liver were significantly decreased(P<0.05,P<0.01). After treatment with cinnamon in model rats,the liver index,serum levels of ALT, AST and MDA were significantly decreased,and the serum contents of TP and ALB,serum activity of T-SOD and the levels of ATP,ADP and AMP in liver were significantly increased(P<0.05,P<0.01). Conclusion:Cinnamon shows a certain protective effects on liver injury in diabetic rats,which is associated with the inhibition of oxidative stress and the regulation of hepatic energy metabolism.关键词：cinnamon;diabetes;liver injury;oxidative stress;energy metabolism
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发布时间：2022-08-31 - 摘要：Objective:To explore the mechanism of treadmill exercise on knee articular cartilage of mice with high fat diet. MethodsThirty male C57BL-6 mice were equally divided into the normal group,high fat diet group and treadmill exercise group. The mice in the high fat diet group and treadmill exercise group were fed with 40% high fat diet for 8 weeks. Then the treadmill exercise group was treated with moderate treadmill training,the treatment course was 45 minutes per time,5 times every week and total 4 weeks. The morphological changes of knee articular cartilage in mice were observed by HE staining and Safranine and Fast Green double dyeing. The expression levels of matrix metalloproteinase-13(MMP-13)and low-density lipoprotein receptor related protein 5(LRP5)in knee joint were determined by immunohistochemistry,and the mRNA expression levels of MMP-13,LRP5 and β-catenin in knee articular cartilage were detected by RT-PCR. Results:Compared with the high fat diet group,the body weight and Lee’s index of mice in the treadmill exercise group were decreased(P<0.05). The Mankin score suggested that there was obvious degeneration in knee articular cartilage in the treadmill exercise group(P<0.05). The mRNA expression of MMP-13 in articular cartilage was increased in the treadmill exercise group compared with the high fat diet group(P<0.05). The immunohistochemical results also showed that the expressions of MMP-13 and LRP5 in knee joint were increased in the treadmill exercise group compared with the high fat diet group(P<0.001). Conclusion:Moderate treadmill exercise can aggravate the knee osteoarthritis process in high fat fed mice,and the increasing expressions of MMP-13 and LRP5 in articular cartilage may induce the knee osteoarthritis.关键词：treadmill exercise;high fat diet;Osteoarthritis;articular cartilage;MMP-13;LRP5
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发布时间：2022-08-31 - 摘要：Objective:To discuss the effects of Shengqing Capsule on abnormal lipid metabolism and breast cancer with liver metastasis by CXCL12-CXCR4 signaling pathway. Methods(1) Human breast cancer cells line MDA-MB-231 was selected and divided into the control group, blank serum group, Epirubicin group and Shengqing Capsule groups with high-and low-concentration. Each group was treated with the corresponding drug contained serum. The effect of drug contained serum on cell proliferation was detected by MTT assay,the effects of drug contained serum on cell migration and invasion were detected by scratch test and Transwell assay. The protein expressions of chemokine ligand CXCL12 and its specific receptor CXCR4 and phosphorylated protein kinase B(p-AKT), protein kinase B(AKT), B-cell leukemia lymphoma-2(Bcl-2)and matrix metallopeptidase-9(MMP-9)were detected by Western blotting. (2) Nude mouse model of breast cancer with liver metastasis and abnormal lipid metabolism was established. The Shengqing Capsule at dose of 0.25 g·kg-1 and Epirubicin at dose of 5 μg·g-1 were given for intervention. The level changes of free fatty acid (FFA) and triglyceride (TG) in plasma were detected,and the effects of Shengqing Capsule on breast cancer with liver metastasis were evaluated. Results:(1) The MTT assay showed that drug contained serum of Shengqing Capsule and Epirubicin could significantly decrease the survival rate of MDA-MB-231 cells in a concentration-dependent manner(P<0.05). The scratch test and Transwell assay showed that drug contained serum of Shengqing Capsule could significantly inhibit the cell invasion and migration. The results of Western blotting showed that drug contained serum of Shengqing Capsule could decrease the protein expressions of CXCL12 and CXCR4 compared with the control group(P<0.05),and down-regulate the protein expressions of MMP-9 and Bcl-2 and reduce the p-AKT level(P<0.05).(2)The results of animal experiment showed that Shengqing Capsule could significantly decrease the levels of TG and FFA in nude mice with abnormal lipid metabolism(P<0.05),and inhibit the liver metastasis of breast cancer. Conclusion:Shengqing Capsule can down-regulate the blood lipid levels and suppress the liver metastasis of breast cancer by inhibiting the expressions of CXCL12,CXCR4 and the related signaling pathway.关键词：shengqing Capsule;breast cancer with liver metastasis;human breast cancer cells line MDA-MB-231;CXCL12;CXCR4
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发布时间：2022-08-31 - 摘要：Objective:To optimize the processing conditions of honeysuckle carbonizing. MethodsTaken the appearance character and the contents of chlorogenic acid and luteoloside as indexes for comprehensive evaluation,the optimization on processing conditions of honeysuckle carbonizing are performed by L9(34)orthogonal design. Results:The optimum processing conditions of honeysuckle carbonizing are stir-frying at 330 ℃ for 10 minutes. Conclusion:The optimized stir-frying processing are stable and feasible with the definite and specific parameters,which can be used to prepare the high quality honeysuckle carbonizing in pieces.关键词：honeysuckle carbonizing;carbonizing;orthogonal test;HPLC;chlorogenic acid;luteoloside
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发布时间：2022-08-31 - 摘要：Through the summary and analysis,this paper reviewed the related mechanism of Qingyi Huaji Recipe. Based on the principle of clearing heat-toxicity and regulating qi-flowing for eliminating dampness,Qingyi Huaji Recipe can stabilize the tumor and prolong the survival time in the treatment of advanced pancreatic cancer. The main mechanism include down-regulating immunosuppressive factors to improve immune suppression,inhibiting tumor associated fibroblasts to improve tumor microenvironment,down-regulating metastasis related gene Ski,decreasing the cell proportion of S phase to inhibit the proliferation of tumor cells,regulating Notch signaling pathway to inhibit protein expression.关键词：Qingyi Huaji Recipe;pancreatic cancer;mechanism
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发布时间：2022-08-31 - 摘要：This paper reviewed the antitumor activity and regulation mechanism of amygdalin. Amygdalin plays a role in antitumor by regulating signaling pathways related to AKT,RICTOR and so on,down-regulating cell cycle related factors and inducing apoptosis of tumor cells,which is effective for bladder cancer, lung cancer, colon cancer and other tumors.
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发布时间：2022-08-31
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