最新刊期
期 6 ， 2017
- 摘要：The theory of qi and blood is one of the important theoretical bases of syndrome differentiation and treatment.According to the pathogenesis characteristics of chronic musculoskeletal diseases as“vital qi deficiency,exogenous pathogen invasion,meridian block and obstruction”, Professor Shi Qi puts forward the therapy of “reconciling qi and blood ” for prevention and treatment of chronic musculoskeletal diseases. Shengyu Decoction is taken as the basic prescription,and 13 new prescriptions that focus on benefiting qi and removing blood stasis as the core are created,which intend to inherit the academic essence of traumatology as“giving priority to qi and taking blood as the first”. Through the clinical and basic research,the principle of “giving priority to qi”refers to recovering the function of qi in promotion,defense and nutrition by benefiting qi,which could regulate hormone levels,improve bone metabolism,promote osteoblast proliferation,delay cell apoptosis,promote proteoglycan and collagen synthesis,improve cell adhesion function and thus maintain the bone structure and function,inhibit inflammatory mediators and regulate cytokines,improve immune function. The principle of “taking blood as the first”means that eliminating blood stasis to promote the circulation of qi,which could improve the hemodynamics and hemorheology of bone and benefit for nutrients into the skeleton,and regulate serum calcium and alkaline phosphatase level. The therapy of “reconciling qi and blood”guide the clinical syndrome differentiation and treatment and significantly enhance the efficacy.关键词：chronic musculoskeletal diseases;theory of qi and blood;giving priority to qi;taking blood as the first
- 5
- |
- 696
- |
- 0
发布时间：2022-08-31 - 摘要：This paper summarized the clinical experience of Professor Su Li in the treatment of Behcet’s disease. He considers that the pathogenesis of this disease is the dysfunction of spleen in transportation as root cause and poisonous damp-heat and static blood in liver meridian as manifestations. In the treatment,he proposes the combination of disease and syndrome differentiation and differentiation of rising and falling of vital qi and pathogen. He holds that the therapy of clearing heat and promoting diuresis and removing blood stasis and detoxication should be applied first and the therapy of strengthening vital qi should be applied throughout the whole treatment. And the treatment by stages should be carried out according to the condition.关键词：Behcet’s disease;clinical experience;experience of famous doctor
- 5
- |
- 254
- |
- 0
发布时间：2022-08-31 - 摘要：This paper discusses the therapy and syndromes of frequent urination due to depression syndrome.Panic and worry can lead to dribbling urination,excessive anxiety can induce frequent urination,and liver qi depression can cause insomnia,frequent urination. The pathogenesis mainly include two categories,one is deficiency of heart qi, deficiency of heart qi and kidney qi(or disharmony between heart and kidney),or heart fire moving downward to intestine,and the other is stagnation of liver qi or transforming into fire. Frequent urination due to depression syndrome shows the dominant or recessive clinical manifestations of depression syndrome,and should pay attention to the treatments based on relieving depression,including dispersing stagnated liver qi for relieving qi stagnation,regulating qi flowing for removing phlegm,clearing liver fire,nourishing heart and clearing heart fire for tranquillization,harmonizing the interaction of heart and kidney. The neural frequency of urination, mental frequency of urination, psychogenic frequency of urination in modern medicine are all within the category of frequent urination due to depression syndrome.关键词：depression syndrome;frequent urination;etiology and pathogenesis;clinical features;treatment based on relieving depression
- 5
- |
- 459
- |
- 0
发布时间：2022-08-31 - 摘要：The treatment views on jaundice in traditional Chinese medicine(TCM) has changed,from ancient theory of “promoting diuresis for removing jaundice”to“cholagogue for removing jaundice”that combined with modern medical knowledge. Through the analysis on the mechanisms and relationship between them,the existing defects of TCM theory,the necessity for the innovation of TCM theory and the relationship between theoretical innovation and clinical practice are explained. It considers that the TCM theory can be developed through the summary of modern new clinical application of Chinese materia medica,which make the connection between the theory and clinical practice more perfect and further guide the clinical practice more effectively and help to understand and accept by the modern scientific system more easily.关键词：promoting diuresis;cholagogue;theory of traditional Chinese medicine;innovation
- 5
- |
- 262
- |
- 0
发布时间：2022-08-31 - 摘要：Objective:To summarize the rule of acupoints selection in acupuncture treatment of cancer pain based on data mining of clinical research literature by traditional Chinese medicine inheritance support system(TCMISS),and provide new ideas for clinical therapy. Methods The clinical research literature about acupuncture in the treatment of cancer pain which included before June 30,2016 were searched in China national knowledge infrastructure(CNKI)database and Wanfang medical network. The information on cancer site,pain site,acupuncture prescriptions were collected in TCMISS. The rule of acupoints selection in acupuncture treatment of cancer pain was analyzed by the software of integrated data mining tools. Results: ①A total of 87 articles are included,and there are 146 acupuncture prescriptions involving 104 acpoints. ②The acupuncture treatment of cancer pain mainly focus on the primary disease of cancer pain,and the top three of the primary disease are liver cancer,gastric cancer and lung cancer. ③Overall,the application frequency of acupoints from high to low are Zusanli(ST36),Neiguan(P6),Sanyinjiao(SP6),Hegu(LI4),Ashi point in order. ④The application frequency of acupoints in treating liver cancer pain from high to low are Zusanli,Sanyinjiao,Ganshu(B18),Qimen(Liv14),Taichong(Liv3)in order. The most common acupoint combination with higher correlation include “Zusanli- Sanyinjiao”,“ Sanyinjiao-Qimen” and “Sanyinjiao-Qimen-Zhangmen(Liv13)”. ⑤The application frequency of acupoints in treating gastric cancer pain from high to low are Zusanli,Zhongwan(CV12),Sanyinjiao,Neiguan and Hegu in order. The most common acupoint combination with higher correlation include “Zusanli-Zhongwan”,“Zusanli-Sanyinjiao”,“Zusanli-Neiguan” . ⑥The application frequency of acupoints in treating lung cancer pain from high to low are Neiguan,Feishu(B13),Kongzui(LU6),Ashi point,Hegu in order. The most common acupoint combination with higher correlation include “Feishu-Hegu”,“Feishu-Neiguan”,“Neiguan-Kongzui”. ⑦The new prescription for liver cancer pain is Taichong,Xinshu(B15),Sanyinjiao,Xingjian(Liv2), Ganshu. The new prescription for gastric cancer pain is Hegu,Shousanli(LI10),Neiguan,Yinlingquan(SP9),Weishu(B21). The new prescription for lung cancer pain is Ashi point,Chize(LU5),Shousanli,Kongzui,Shenshu(B23). Conclusion: As an important assistant tool for data mining and rule analysis of the hidden clinical information,TCMISS can conclude the rule of acpoint compatibility in clinical acupuncture treatment of cancer pain,and the new prescriptions created by the system can provide new ideas for clinical acupuncture treatment of cancer pain.关键词：cancer pain;acupuncture;acpoint compatibility;rule analysis;data mining;TCMISS
- 5
- |
- 931
- |
- 0
发布时间：2022-08-31 -
Analysis on the distribution of chronic gastritis in TCM syndromes and Helicobacter pylori infection
摘要：Objective:To investigate and analyze the distribution of chronic gastritis in TCM syndromes and Helicobacter pylori(HP)infection. Methods The related data on 412 patients with chronic gastritis were collected,and the distribution of chronic gastritis in TCM syndrome and HP infection were performed the statistical analysis. Results:①In 412 cases of chronic gastritis,there were 321 HP positive patients who account for 77.9% and 91 HP negative patients who account for 22.1%. ②The syndrome of dampness-heat of spleen and stomach(30.1%) and the syndrome of deficiency of spleen qi and stomach qi(29.4%)were most common in patients with chronic gastritis,about 60%. The other syndromes were damp-turbidity retention in middle-jiao(16.3%),incoordination between liver and stomach(8.7%),stagnated heat of liver and stomach(8.5%),deficiency of stomach yin(4.3%)and blood stasis in stomach collateral(2.7%). ③In HP positive patients,the syndrome of dampness-heat of spleen and stomach accounts for the highest proportion(32.7%). In negative positive patients,the syndrome of deficiency of spleen qi and stomach qi accounts for the highest proportion(45.1%). Conclusion: The syndrome of dampness-heat of spleen and stomach and the syndrome of deficiency of spleen qi and stomach qi are the most common TCM syndromes in patients with chronic gastritis. Its incidence is closely related to Helicobacter pylori infection.关键词：chronic gastritis;TCM syndrome;Helicobacter pylori- 6
- |
- 485
- |
- 0
发布时间：2022-08-31 - 摘要：This paper introduced Ma Dazheng’s clinical experience in the treatment of menstrual diseases with couplet medicines,including Rhizoma Dioscoreae-Endothelium Corneum Gigeriae Galli with effects of tonifying the spleen for stimulating the menstrual flow in treating amenorrhoea,Lignum Dalbergiae Odoriferae-Flos Inulae with effects of descending qi and activating blood circulation to stimulate the menstrual flow,Polyporus Umbellatus-Poria with effects of eliminating dampness and diuresis to stop bleeding,Ophicalcitum-Tremolite asbestos Actinolite with effects of removing blood stasis for hemostasis in treating blood symptoms,vinegar-Radix Sanguisorbae with effects of clearing heat and cooling blood for astringency,Rhizoma Ligustici Chuanxiong-liquor with effects of promoting qi-flow and activating blood circulation to remove blood stasis. Proven medical cases were presented.关键词：menstrual diseases;traditional Chinese medicine;couplet medicines;experience of famous doctors;Ma Dazheng
- 5
- |
- 226
- |
- 0
发布时间：2022-08-31 - 摘要：This paper introduced Professor Liu Jianqiu’s experience in treating asthma. He considers that it should eliminate the pathogenic factors when asthma attacks. Based on six main pathogenic factors such as wind,heat,phlegm,qi,cold and blood stasis,he puts forwards six methods including therapy of dispelling pathogenic wind for clearing phlegm,therapy of clearing heat and dispersing lung qi,therapy of warming lung for resolving fluid retention,therapy of promoting blood circulation for removing blood stasis,therapy of warming yang for regulating qi-flowing,therapy of strengthening vital qi for relieving desertion. When asthma dose not attack,it should strengthen vital qi. Based on the pathogenic basis as deficiency of lung,spleen and kidney,he puts forwards two methods including therapy of strengthening spleen and benefiting qi,therapy of regulating and supplementing lung and kidney.关键词：asthma;clinical experience;Liu jianqiu
- 5
- |
- 209
- |
- 0
发布时间：2022-08-31 - 摘要：This paper introduced Yang Zhimin’s experience in the treatment of chronic urticaria,based on the ideas of adroitly guiding actions according to circumstances and strengthening body resistance for promoting drainage. He considers the internal latent pathogen as the cause for people suffering from this disease that was refractory after long time treatment. According to the characteristics and changes of urticaria,the treatments should successively apply Danggui Sini Decoction,Guizhi Fuzi Decoction and Gegen Decoction,which show the exact efficacy.关键词：chronic urticaria;Danggui Sini Decoction;Guizhi Fuzi Decoction;Gegen Decoction;clinical experience;Yang Zhimin
- 5
- |
- 533
- |
- 0
发布时间：2022-08-31 - 摘要：Inherited the syndrome classification of six meridians in the chapter about fever of Basic Questions(Su Wen Re Lun), taken the theory of meridian and collateral as the basis of syndrome differentiation and treatment, the theory of six meridians was enriched and developed in Treatise on Cold Pathogenic Diseases from some aspects including enrichment of syndrome differentiation of six meridians,development of identification of progression and self healing of six meridians,supplement of transmission patterns in six meridians related diseases,enlargement of syndrome and classification of six meridians,improvement of treatment principles and methods in six meridians related diseases, which improved the application value of syndrome differentiation and treatment of six meridians in clinic.关键词：discussion on fever;Treatise on Cold Pathogenic Diseases;theory of meridian and collateral;theory of six meridians
- 5
- |
- 590
- |
- 0
发布时间：2022-08-31 - 摘要：This paper briefly analyzed the effects of invigorating qi and blood in promoting method. As an important method in the treatment of sore and ulcer,the medicine composition of the promoting method is mainly based on the drugs with effects of invigorating qi and blood and promoting blood circulation for expelling toxin,and invigorating qi and blood is the basic element and foundation. In prescription,Radix Astragali seu Hedysari,Radix Ginseng and Radix Angelicae Sinensis are commonly used invigorating drugs. These drugs play an important role such as bacteriostasis,immune regulation,reducing blood coagulation in the treatment of sore and ulcer.关键词：promoting method(promoting pustulation of ulcer by strengthening vital qi);invigorating qi and blood;anti-infection;immune regulation;blood coagulation function
- 6
- |
- 241
- |
- 0
发布时间：2022-08-31 - 摘要：Objective:To observe the effects of Compound Fo’ercao Mixture on the serum levels of inflammatory factors(IL-8,TNF-α) and expressions of Toll like receptors(TLRs) in peripheral blood mononuclear cells of patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD). Methods 120 patients with AECOPD were randomly divided into the treatment group and control group,60 cases in each group. Both groups were given the conventional therapy of western medicine. In addition,the treatment group was treated with Compound Fo’ercao Mixture,and the control group was treated with the placebo,with a course of 14 days. The changes of TCM syndrome scores,serum levels of IL-8,TNF-α and expressions of TLR2,TLR4 in peripheral blood mononuclear cells were observed and compared. Results: ①Finally 107 cases completed the whole trial,among 51 cases in the treatment group and 56 cases in the control group. ②After treatment,the decrease of the scores on cough,expectoration and the total score in the treatment group were more significant than those in the control group(P<0.05). ③After treatment,the decrease of IL-8 level in the treatment group was more significant than that in the control group(P<0.05). ④After treatment,the increase of the expression levels of TLR2 and TLR4 in the treatment group were more significant than those in the control group(P<0.05). ⑤There were good negative correlations between the serum levels of IL-8,TNF-α and expression levels of TLR2 and TLR4 in peripheral blood mononuclear cells before and after treatment. ⑥All patients had no abnormality in routine inspection and severe adverse reactions. Conclusion: Compound Fo’ercao Mixture combined with conventional therapy of western medicine can significantly improve the main symptoms such as cough and expectoration in AECOPD patients,which may be associated with alleviating the airway inflammation and enhancing the innate immune response.关键词：chronic obstructive pulmonary disease;acute exacerbation;Compound Fo’ercao Mixture;inflammatory reaction;immune response
- 5
- |
- 163
- |
- 0
发布时间：2022-08-31 - 摘要：Objective:To observe the effects of Fuzheng Guben RecipeⅠon the immune function and side reactions of chemotherapy in patients of advanced non small cell lung cancer(NSCLC)with syndrome of lung and spleen deficiency. Methods 60 patients with NSCLC were randomly divided into the treatment group and control group,30 cases in each group. The control group was treated with conventional chemotherapy,and the treatment group was treated with Fuzheng Guben RecipeⅠbased on the treatment for the control group. The treatment course was 12 weeks in the control group and 13 weeks in the treatment group. The toxic and side reactions induced by chemotherapy were observed,the changes of serum levels of T cell subsets (CD3+,CD4+,CD8+) and immune cytokines (IFN-γ,IL-10) were compared. Results: ①After treatment,there were statistically significant differences on the levels of CD3+,CD4+,CD4+/CD8+,CD4+CD25+Treg between the two groups,the improvement on the levels of T cell subsets in the treatment group was obviously better than that in the control group(P<0.05). ②Compared with the control group after treatment,the IFN-γ level was significantly increased in the treatment group,while the IL-10 level was significantly decreased(P<0.05). ③Compared with the control group after treatment,the reactions of nausea and vomiting,leukopenia and liver injury were significantly improved in the treatment group(P<0.05),while there was no statistically significant difference on the grade of kidney injury between the two groups(P>0.05). The incidence rates of toxic and side reactions including nausea and vomiting,leukopenia and liver injury in the treatment group were all obviously lower than those in the control group(P<0.05). Conclusion: Fuzheng Guben RecipeⅠ can significantly improve the immune function in patients of advanced non small cell lung cancer with syndrome of lung and spleen deficiency,alleviate the toxic and side reactions of chemotherapy.关键词：non small cell lung cancer;Fuzheng Guben Recipe;immune function;cytokines;chemotherapy;toxic and side reactions
- 5
- |
- 147
- |
- 0
发布时间：2022-08-31 - 摘要：Objective:To observe the clinical efficacy of Modified Weichang’an Decoction combined with 5-fluorouracil based chemotherapy in treating elderly patients with stage Ⅳ colorectal cancer. Methods 133 elderly patients with stage Ⅳ colorectal cancer were divided into the treatment group (68 cases) and control group (65 cases). All patients were treated with 5-fluorouracil based chemotherapy for 3 courses. In addition,the treatment group was orally treated with Modified Weichang’an Decoction. The short-term efficacy,toxic and adverse reactions,quality of life and overall survival in the two groups were compared. Results:①In short-term efficacy,there were no statistically significant differences on the total effective rate and disease control rate between the two groups(P>0.05). ②The life quality of patients in the treatment group was better than that in the control group(P<0.01). ③The median PFS and median OS in the treatment group were significantly longer than those in the control group(P<0.05). ④The toxic and adverse reactions such as leukocyte reduction and peripheral neurotoxicity in the treatment group were less than those in the control group(P<0.05,P<0.01). Conclusion: Modified Weichang’an Decoction combined with 5-fluorouracil based chemotherapy can enhance the short-term efficacy,reduce the toxic and adverse reactions,improve the life quality and prolong the survival in treating elderly patients with stage Ⅳ colorectal cancer.关键词：colorectal cancer;Weichang’an Decoction;quality of life;overall survival;elderly
- 5
- |
- 135
- |
- 0
发布时间：2022-08-31 - 摘要：Objective:To observe the influence of Yiwei Xiaoai Decoction combined with OLF chemotherapy on life quality and immune function of patients with advanced gastric cancer. Methods 84 patients with advanced gastric cancer were randomly divided into the control group(41 cases)and Chinese medicine group(43 cases). Both groups were given OLF chemotherapy,and the Chinese medicine group was treated with Yiwei Xiaoai Decoction additionally. After 3 cycles of chemotherapy,the changes of main TCM syndrome scores,scores of life quality in QLQ-C30 scale and immune function(CD3+,CD4+,CD8+)in both groups were observed. Results:①For the comparison between treatment before and after,there were statistically significant differences on the syndrome scores of epigastric pain,eating less and anorexia,adverse ascending of stomach qi,weakness and laziness to speak and the total score in the two groups(P<0.05), and there was statistically significant difference on the syndrome score of marasmus in Chinese medicine group(P<0.05). For the comparison after treatment,there were statistically significant differences on all the syndrome scores and the total score between the two groups(P<0.05).②For the comparison between treatment before and after,there were statistically significant differences on the scores of physical function,emotional function,cognitive function and overall life quality in Chinese medicine group(P<0.05),there were statistically significant differences on the scores of cognitive function and overall life quality in the control group(P<0.05). For the comparison after treatment,there were statistically significant differences on the scores of physical function,emotional function,cognitive function and overall life quality between the two groups(P<0.05).③For the comparison between treatment before and after,there were statistically significant differences on the levels of CD3+,CD4+,CD8+ and CD4+/CD8+in Chinese medicine group(P<0.05),there was statistically significant difference on the level of CD3+in the control group(P<0.05). For the comparison after treatment,there were statistically significant differences on the levels of CD3+,CD4+,CD8+ and CD4+/CD8+between the two groups(P<0.05). Conclusion: Yiwei Xiaoai Decoction combined with OLF chemotherapy can significantly improve the life quality of patients with advanced gastric cancer,and enhance the immune function.关键词：advanced gastric cancer;Yiwei Xiaoai Decoction;chemotherapy;life quality;immune function
- 5
- |
- 172
- |
- 0
发布时间：2022-08-31 - 摘要：Objective:To observe the clinical efficacy of Shugan Liqi Tianjing Decoction in the treatment of adverse reactions caused by breast cancer postoperative endocrine therapy. Methods 62 patients with adverse reactions caused by breast cancer postoperative endocrine therapy were randomly divided into the treatment group and control group,31 cases in each group.The control group was only treated with conventional endocrine therapy,while the treatment group was treated with Shugan Liqi Tianjing Decoction based on the treatment for the control group,with a course of two months. The Kupperman improved score,endometrial thickness,parameters of blood lipid and bone mineral density(BMD) were observed and compared. Results:①For the comparison of the difference of Kupperman improved score before and after treatment,the difference in the treatment group was obviously greater than that in the control group(P<0.05).②For the comparison of the difference of endometrial thickness before and after treatment,the difference in the treatment group was obviously lower than that in the control group(P<0.05).③After treatment,there was statistically significant difference on the triacylglycerol level between the two groups(P<0.05).④After treatment,the BMD levels of L2-L4 and femoral neck in the treatment group was obviously higher than those in the control group(P<0.05). Conclusion: Shugan Liqi Tianjing Decoction can significantly relieve the adverse reactions caused by breast cancer postoperative endocrine therapy,and improve the life quality of patients and prognosis.关键词：breast cancer;endocrine therapy;adverse reactions;dispersing stagnated liver qi and regulating qi-flowing;tonifying kidney essence
- 5
- |
- 171
- |
- 0
发布时间：2022-08-31 - 摘要：Objective:To observe the clinical efficacy of No.1 Tangshen Decoction combined with routine therapy of western medicine in treating diabetic nephropathy of stage Ⅲ with syndrome of qi-yin deficiency. Methods Sixty patients of stage Ⅲ diabetic nephropathy with syndrome of qi-yin deficiency were randomly divided into the treatment group and control group,30 cases in each group. Both groups were treated with routine therapy of western medicine,and the treatment group was treated with No.1 Tangshen Decoction additionally,with a course of 3 months. The clinical efficacy was observed,and the changes of TCM syndrome score,urinary albumin excretion rate (UAE),serum creatinine (Scr),glycosylated hemoglobin (HbA1c),fibrinogen degradation products (FDP),total cholesterol (TC) and triacylglycerol(TG)were compared. Results: ①The clinical total effective rate was 86.67% in the treatment group and 60.00% in the control group. The clinical efficacy of the treatment group was significantly better than that of the control group(P<0.05). ②For the comparison of the difference of TCM syndrome score between treatment before and after,there was statistically significant difference between the two groups. The improvement on TCM syndrome score in the treatment group was more significant than that in the control group(P<0.05). ③After treatment,there were statistically significant differences on the levels of UAE,TG and FDP between the two groups(P<0.05). Conclusion: No.1 Tangshen Decoction can improve the clinical symptoms of patients of stage Ⅲ diabetic nephropathy with syndrome of qi-yin deficiency,and decrease the urinary microalbumin. Its mechanism may be related to regulating lipid metabolism and improving renal hemodynamics.关键词：diabetic nephropathy;No.1 Tangshen Decoction;qi-yin deficiency;collaterals obstruction by blood stasis;glucose and lipid metabolism disorder
- 5
- |
- 201
- |
- 0
发布时间：2022-08-31 - 摘要：Objective:To observe the clinical efficacy of Kuoxin Recipe in the treatment of dilated cardiomyopathy. Methods 88 patients with dilated cardiomyopathy were randomly divided into the treatment group (43cases) and control group (45 cases). Both groups were received the conventional therapy of western medicine,and the treatment group was orally treated with Kuoxin Recipe additionally,with a course of 6 months. The clinical efficacy was observed,the changes of New York Heart Association(NYHA)functional class,related indexes of cardiac ultrasound and serum level of brain natriuretic peptide(BNP)were compared. Results: ①The clinical total effective rate of the treatment group and control group were 90.70% and 73.33% respectively,the clinical efficacy of the treatment group was significantly better than that of the control group(P<0.05). ②After treatment,the NYHA functional class of the treatment group was significantly better than that of the control group(P<0.05).③After treatment,the levels of cardiac output(CO),cardiac index(CI)and left ventricular ejection fraction(LVEF)in the treatment group were significantly higher than those in the control group(P<0.05),while the levels of left ventricular end diastolic dimension(LVEDd)and BNP were significantly lower than those of the control group(P<0.05). Conclusion: Kuoxin Recipe can be used in the treatment of dilated cardiomyopathy,which obviously improve the cardiac function,clinical symptoms and life quality of patients.关键词：dilated cardiomyopathy;cardiac distention;Kuoxin Recipe;deficiency in origin and excess in superficiality
- 5
- |
- 220
- |
- 0
发布时间：2022-08-31 - 摘要：Objective:To observe the clinical efficacy of Xiaoying Mixture combined with glucocorticoid in the treatment of thyroid associated opthalmopathy(TAO)above active stage III grade. Methods Sixty patients with TAO above active stage III grade were randomly divided into the treatment group and control group,30 cases in each group. Both groups were treated with stosstherapy of methylprednisolone. Meanwhile,the treatment group was orally treated with Xiaoying Mixture and the control group was orally treated with the placebo,with a course of 3 months. The clinical efficacy was observed,and the changes of NOSPECS grades and clinical activity scale(CAS)score were compared. Results: ①The clinical total effective rate of the treatment group and control group was 93.33% and 83.33% respectively. The clinical efficacy of the treatment group was significantly better than that of the control group(P<0.05).②After treatment,the improvement on NOSPECS grades in the treatment group was more significant than that in the control group(P<0.05).③For the comparison between treatment before and after,the differences on CAS score was statistically significant in both groups(P<0.05).For the comparison of the difference of CAS score before and after treatment,the difference in the treatment group was significantly higher than that in the control group(P<0.05). Conclusion: Compared with the single glucocorticoid stosstherapy,Xiaoying Mixture combined with glucocorticoid can more significantly alleviate the clinical symptoms of patients with TAO above active stage III grade and control the disease development.关键词：thyroid associated ophthalmopathy;goiter;exophthalmos;Xiaoying Mixture;hormone stosstherapy;placebo
- 5
- |
- 152
- |
- 0
发布时间：2022-08-31 - 摘要：Objective:To observe the clinical efficacy of Qingying Xiere Huayu Decoction in the treatment of early deep venous thrombosis. Methods 60 patients with early deep venous thrombosis were randomly divided into the treatment group and control group,30 cases in each group.Both groups were given the routine basic nursing. In addition,the treatment group was treated with Qingying Xiere Huayu Decoction and the control group was treated with low molecular weight heparin,with a course of 14 days. The clinical efficacy was observed,the changes of related biochemical parameters (platelet count,prothrombin time and D-dimer) and circumference of lower limbs were compared. Results: ①The clinical total effective rate was 93.33% in the treatment group and 83.33% in the control group. The clinical efficacy of the treatment group was significantly better than that of the control group (P<0.05) . ②After treatment,there were no statistically significant differences on the platelet count and prothrombin time between the two groups(P>0.05),but the decrease of D-dimer level in the treatment group were more greater than those in the control group (P<0.05) .③After treatment,the reduction of circumference of lower limbs(ankle,fibula,10cm above patella and femur)in the treatment group were more significant than those in the control group (P<0.05) . Conclusion: Qingying Xiere Huayu Decoction shows good efficacy in the treatment of early deep venous thrombosis,which can significantly alleviate the swelling and pain of lower limbs,and improve the blood hypercoagulable state of patients.关键词：deep venous thrombosis;acute stage;subacute stage;thigh swelling;Qingying Xiere Huayu Decoction;blood hypercoagulable state
- 5
- |
- 168
- |
- 0
发布时间：2022-08-31 - 摘要：Objective:To observe the preventive effects of “Yuanqitong” Chinese herbal medicated pillow with fumigation for cervical spondylosis. Methods 100 high-risk patients with cervical spondylosis who met the observation condition were randomly divided into the control group and observation group,50 cases in each group. The control group was treated with health education and sports instruction,the observation group was treated with “Yuanqitong” Chinese herbal medicated pillow for fumigation once a day based on the treatment for the control group,with a course of 3 months. After treatment for 3 months,the scores of pain rating index (PRI),visual analogue scale (VAS) and present pain intensity (PPI) were evaluated,and the efficacy was compared according to the symptom scores. Results: After treatment,all the scores were obviously decreased in both groups compared with treatment before(P<0.01),and the PRI score in the observation group was significantly lower than that in the control group (P<0.01),while there were no significant differences on the scores of VAS and PPI between the two groups (P>0.05). The total effective rate of the control group was 88%,and the total effective rate of the observation group was 94%,the efficacy of the observation group on syndrome improvement was better than that of the control group (P<0.01). Conclusion: “Yuanqitong” Chinese herbal medicated pillow with fumigation can significantly decrease the syndrome scores of high-risk population with cervical spondylosis,which shows good efficacy in the prevention of the occurrence and development of cervical spondylosis.关键词：Chinese herbal medicated pillow;fumigation;cervical spondylosis;high-risk group;prevention
- 5
- |
- 176
- |
- 0
发布时间：2022-08-31 - 摘要：This paper discussed the practicability,validity and clinical application value of the method of “prescription selection based on flavor”from some aspects including the correspondence between five flavours and zang-fu viscera,advantages of five flavours,disadvantages of five flavours,five flavours in prescriptions,clinical practice and so on.关键词：prescription selection based on flavor;five flavours;application of classical prescription
- 5
- |
- 333
- |
- 0
发布时间：2022-08-31 - 摘要：According to the records in materia medica treatises and medical books,this article summarizes and analyzes the clinical efficacy and application of lotus leaf,mainly including clearing summer-heat,rising spleen qi,cooling blood for hemostasis,decreasing lipid and reducing weight,which show the wide clinical significance.关键词：lotus leaf;clinical efficacy and application;clearing summer-heat;rising spleen qi;cooling blood for hemostasis;decreasing lipid and reducing weight
- 5
- |
- 277
- |
- 0
发布时间：2022-08-31 - 摘要：Objective:To study the effects and mechanism of Jianpi Qinghua Recipe on body weight of diet induced obesity(DIO)mice. Methods DIO model was established in C57/BL by high fat feeding. After successful modeling,the mice were randomly divided into the model group and Jianpi Qinghua Recipe(JPQH)group according the body weight. C57/BL mice fed with normal diet were taken as the normal control group. The JPQH group was treated with Jianpi Qinghua Recipe at daily dose of 15 g crude drug/kg (equivalent dose in mice) for intragastric administration,the model group and normal control group were treated with equivalent 0.9% NaCl solution,with a course of 6 weeks. The differences on the metabolic phenotypes in each group were evaluated by body weight,body fat and liver pathology. The protein and gene expressions of IκB kinase ε(IKKε)and uncoupling protein-1(UCP-1)in adipose tissue were detected by Western blotting and RT-PCR. Results: Compared with the normal control group,the body weight and body fat content were increased significantly in the model group(P<0.05),while Jianpi Qinghua Recipe could significantly improve the increase of body weight and fat caused by high fat feeding(P<0.05). Pathological observation showed that Jianpi Qinghua Recipe could significantly improve the liver fat ectopic deposition induced by high fat diet. Compared with the normal control group,the protein and gene expressions of IKKε in adipose tissue were significantly up-regulated in the model group(P<0.05),while the protein and gene expressions of UCP-1 were significantly down-regulated(P<0.05). Compared with the model group,the protein and gene expressions of IKKε in adipose tissue were decreased in JPQH group(P<0.05),and the protein and gene expressions of UCP-1 were increased(P<0.05). Conclusion: Jianpi Qinghua Recipe can decrease the body fat content in obese mice,and significantly improve the increase of body weight and liver fat ectopic deposition caused by high fat feeding. Its mechanism may be associated with regulating IKKε / UCP-1 pathway and improving the body energy consumption.关键词：Jianpi Qinghua Recipe;obesity;IKKε;UCP-1;energy metabolism
- 5
- |
- 173
- |
- 0
发布时间：2022-08-31 - 摘要：Objective:To investigate the influence of Danzhi Jiangtang Capsule on serum levels of stromal cell-derived factor-1α(SDF-1α)and cell cycle regulatory protein P27 in diabetic rats. Methods48 SD rats were divided into the normal control group,model group,Danzhi Jiangtang Capsule(DJC)groups with high-and low-dose,pioglitazone group. Except the normal control group,the rats in the other groups were fed with high fat diet for 4 weeks,and treated with streptozotocin (STZ) solution for intraperitoneal injection at dose of 35 μg/g only once. After successful modeling,the rats were received the intragastric administration for continuous 8 weeks. The blood was collected from abdominal aorta. The serum levels of SDF-1α and P27 were determined by double antibody sandwich ELISA. The blood glucose and glycosylated hemoglobin (HbA1c) were detected. Results:Compared with the normal group,the level of SDF-1α in the model group was obviously decreased(P<0.01),while the expression of P27 was increased(P<0.01). Compared with the model group,the level of SDF-1α in the DJC groups with high- and low-dose and pioglitazone group was significantly increased(P<0.01),and the level of P27 was obviously decreased(P<0.01). For the comparison among the three treatment groups,there were no statistically significant differences on the levels of SDF-1α and P27(P>0.05). Compared with the normal group,the levels of blood glucose and HbA1c in the model group were significantly increased. After the treatment of Danzhi Jiangtang Capsule with high- and low-dose,the levels of blood glucose and HbA1c were obviously decreased. The correlation analysis showed that there were significant negative correlation between the blood glucose and SDF-1α (P<0.01) and significant positive correlation between the blood glucose and P27(P<0.01). Conclusion:Danzhi Jiangtang Capsule can increase the serum SDF-1α level and inhibit the high expression of P27 in diabetic rats,which delays the diabetic renal lesions and protects the kidney function. It shows definite effects on decreasing the blood glucose and HbA1c.关键词：diabetes;therapy of benefiting qi and nourishing yin and promoting blood circulation;Danzhi Jiangtang Capsule;stromal cell-derived factor-1α;cell cycle regulatory protein P27
- 5
- |
- 70
- |
- 0
发布时间：2022-08-31 - 摘要：Objective:To investigate the protective effects of Xiaochaihu Decoction and Danggui Shaoyao Powder with single and combined application on immunological liver injury. Methods Seventy-two KM mice were randomly divided into the blank group, model group, Xiaochaihu Decoction(XCHD,6.63 g/kg) group, Danggui Shaoyao Powder(DGSYP,11.31 g/kg)group, combination(Chaigui Decoction,17.94 g/kg)group and positive control group (bifendate 0.2 μg/g and diammonium glycyrrhizinate 0.3 μg/g). Except the blank group, the model of immunological liver injury was established in the other group by intravenous injection of concanavalin A(Con A)in mouse tail. Each group was treated with the corresponding intervention for 7 days. The levels of ALT, AST, ALB and TP were detected by semi-automatic biochemical analyzer. The pathological section was observed by HE staining. The activity of SOD and the contents of GSH and MDA in liver tissue were determined by colorimetry. The levels of TNF-α,IL-1 and IL-6 were detected by ELISA. The protein expressions of Bax, Bcl-2 and Caspase-3 were detected by Western blotting. The T lymphocyte subsets were detected by APAAP method. Results: Compared with the model group, XCHD could decrease the ALT and AST levels, reduce the IL-1 level, decrease the MDA content, and Chaigui Decoction significantly decrease the Bcl-2 protein expression. Compared with the model group, DGSYP could decrease the ALT level, reduce the serum levels of TNF-α,IL-1 and IL-6, and reduce the protein content of Bcl-2. Chaigui Decoction showed significantly protective effects. The effects on improving above indicators in the combination group were better than those in the XCHD group and DGSYP group,and Chaigui Decoction significantly improved the ratio of CD4+/CD8+ in serum. Conclusion: Xiaochaihu Decoction and Danggui Shaoyao Powder show the protective effects on ConA induced immunological liver injury respectively. The combination of the two prescriptions shows better effects than the single application. The mechanism may be associated with promotion on anti-oxidation,anti-apoptosis and regulation of immune disorders.关键词：Xiaochaihu Decoction;Danggui Shaoyao Powder;immunological liver injury;concanavalin A
- 5
- |
- 431
- |
- 0
发布时间：2022-08-31 - 摘要：Objective:To observe the effects of moxibustion at Qihai(CV6)and Guanyuan(CV4) acupoints on behavior and immune systems of chronic fatigue rats. Methods SD rats were randomly and equally divided into the normal control group,model control group and moxibustion group. Except the normal control group,rat model of chronic fatigue was established in the other groups by composite stress method. The moxibustion group was treated with moxibustion at Qihai and Guanyuan acupoints after modeling. The behavior(experiments of swimming exhaustion and rat tail suspension)of rats in each group were observed before and after modeling and after moxibustion intervention. After moxibustion intervention,the serum immunological indexes(IgA,IgM,IgG,C3,C4)of rats in each group were detected and compared. Results: Compared with the normal control group after modeling,the swimming time of exhaustion was decreased and the suspension time of rat tail was increased in the model control group and moxibustion group(P<0.05). Compared with the model control group after moxibustion intervention,the swimming time of exhaustion was increased and the suspension time of rat tail was decreased in the moxibustion group,and the levels of immunological indexes(IgA,IgM,IgG,C3,C4)were significantly increased(P<0.05). Conclusion: Moxibustion at Qihai and Guanyuan acupoints show significant effects on improving chronic fatigue.关键词：chronic fatigue syndrome;moxibustion;Qihai acupoints(CV6);Guanyuan acupoints(CV4)
- 5
- |
- 784
- |
- 0
发布时间：2022-08-31 - 摘要：Objective:To study the inhibitory effect and mechanism of Compound Purple Ginseng polysaccharides(CPGP)in hepatocarcinoma 22(H22)transplanted mice. Methods 60 male ICR mice were selected and H22 tumor-bearing mice model was established except the blank group. Then the mice were randomly divided into the model group,cyclophosphamide(CTX,25 μg/g),CPGP groups with low-(70 μg/g),middle-(140 μg/g),high-(280 μg/g)dose,10 mice in each group. Each group were given the corresponding intervention,with a course of 10 days. The general condition of mice was observed. The tumor inhibition rate and organ indexes were calculated. The serum levels of TNF-α,IL-2,IFN-γ were determined by ELISA. The T-lymphocyte subsets in spleen were detected by flow cytometry. Results: The tumor inhibition rates of CTX group and CPGP groups with low-, middle- and high-dose on H22 were 65.01%、40.19%、51.32%、57.84% respectively. Compared with the model group,the body weight and immune organ indexes were significantly increased in CPGP groups with low-, middle- and high-dose(P<0.05,P<0.01),the serum levels of TNF-α,IL-2,IFN-γ were increased in CPGP group with high-dose(P<0.05),and the ratio of CD4+/CD8+ in splenic T-lymphocyte subsets was increased in CPGP groups with low-, middle- and high-dose(P<0.01).Compared with the model group,the body weight and immune organ indexes,the serum levels of TNF-α,IL-2,IFN-γ and the ratio of CD4+/CD8+ in splenic T-lymphocyte subsets were significantly decreased in CTX group(P<0.05,P<0.01).Compared with CTX group,the body weight and immune organ indexes,the serum levels of TNF-α,IL-2,IFN-γ and the ratio of CD4+/CD8+ in splenic T-lymphocyte subsets were significantly increased in CPGP-treated mice(P<0.05,P<0.01). Conclusion: CPGP shows significantly inhibitory effects on transplanted H22 tumor in mice. Its mechanism may be associated with enhancing immune function.关键词：Compound Purple Ginseng polysaccharide;H;22;tumor-bearing mice;antitumor;immune organs;flow cytometry
- 5
- |
- 165
- |
- 0
发布时间：2022-08-31 - 摘要：This article reviewed the experimental research progress of Astragaloside IV on bronchial asthma,including the effects on inflammatory cells,inflammatory cytokines,chemokine receptors and transcription factors that associated with asthma.关键词：Astragaloside IV;bronchial asthma;experimental research;review
- 7
- |
- 304
- |
- 0
发布时间：2022-08-31 - 摘要：This paper systematically analyzed the response of different acupoints in the same meridian when the body in different conditions including the normal physiological state,the pathological state of disease damage and acupuncture intervention with low frequency,and compared the differences of acupuncture on different acupoints in the same meridian on the regulatory effects on the related viscera function. It finds that there are some differences of acupuncture on different acupoints in the same meridian on the response and regulatory effects on the related viscera function when the body in different conditions.关键词：meridians and collaterals;acupoints;correlation between acupoint and viscera
- 5
- |
- 340
- |
- 0
发布时间：2022-08-31
- Technical support is provided by Beijing Founder electronics co., LTD 沪ICP备13044091号
沪公网安备 31011502015228号 - It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
- Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.
- Total Visits：70575 Visits Today：56
0