最新刊期
期 12 ， 2017
- 摘要：This paper introduces Professor Shi Qi’s academic views about treatment on acute rheumatoid arthritis from“heat-toxicity bi”. It is considered that this disease is caused by accumulated heat-toxicity that further flow into muscles,bones and joints and lead to stagnation of qi and blood. The clinical practice should treat from“heat-toxicity bi”,which base on the therapy of clearing heat-toxicity,eliminating wind-dampness,dredging channels and meridians,and combine with the therapy of dispelling wind and clearing heat,clearing heat and promoting diuresis,nourishing yin and clearing heat,removing blood stasis and dissipating phlegm. One proven case is presented.关键词：acute rheumatoid arthritis;treatment from“heat-toxicity bi”;experience of famous doctor;Shi Qi
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发布时间：2022-08-31 - 摘要：This paper discusses the therapy and syndrome of constipation due to depression syndrome. Although its disease location is at the large intestine, but the constipation is closely related to the disharmony of five zang viscera caused by five minds. The etiology and pathogenesis involve some aspects as follow:There is connection between the liver and intestine, so liver depression may result in qi stagnation in the large intestine. Excessive worry or thinking may influence the spleen and lung, qi accumulation in the spleen and lung may lead to obstruction in the large intestine, while qi deficiency in the spleen and lung could fail to promote the excretion. Overreaction of five minds may transform into fire and consume the body fluid to cause constipation. Over exertion and fatigue impairing the heart and spleen may induce the deficiency of essence and blood, which fail to nourish the large intestine. The six stagnation diseases caused by seven emotions could bring about food retention, phlegm stagnation and blood stasis, and result in obstruction of intestine. The treatment on constipation due to depression syndrome mainly include the therapy of dispersing stagnated liver qi for relieving stagnation, clearing liver-fire, activating qi for eliminating dampness, relieving epigastric distention and removing stagnation, clearing heart fire for tranquillization, invigorating spleen and nourishing blood, dissipating phlegm and resolving stasis. The key lies in regulating qi activities, clearing stagnation and increasing body fluid to promote the excretion. In modern medicine, acute constipation, irritable bowel syndrome with predominant constipation, functional constipation, functional defecation disorders and other chronic constipation induced by mental and psychological factors, as well as somatization disorder, generalized anxiety disorder, depression and other mental disorders which accompanied by constipation, could be roughly within the scope of constipation due to depression syndrome.关键词：depression syndrome;constipation;etiology and pathogenesis;treatment based on relieving depression
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发布时间：2022-08-31 - 摘要：This paper explains the concept of generalized perianal abscess from the background,definition,interpretation and diagnostic elements,and discusses the influence factors from patients and medical treatment related aspects. The theoretical basis of thread-dragging therapy in the treatment of generalized perianal abscess is investigated from literature research and modern research progress.关键词：generalized perianal abscess;carbuncle;concept;influence factor;thread-dragging therapy
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发布时间：2022-08-31 - 摘要：Objective:To discuss the Chinese medical syndrome characteristics of first-episode schizophrenia and rules of patterns classification,and provide reference for the objectification of Chinese medical syndrome and differentiation and treatment of this disease. MethodsThe observation table of Chinese medical syndrome on first-episode schizophrenia was formulated. By the standardized collection of four diagnostic information,a total of 140 patients with first-episode schizophrenia were included. The database was established,and the study of Chinese medical syndrome was performed by multivariate mathematical statistics such as factor analysis and cluster analysis. Results:Totally 22 common factors were obtained in the study of Chinese medical syndrome,which merged into 5 combinations of syndrome factors that most consistent with the clinic. According to the descending order,the syndrome of stagnation of qi and blood could account for 47.86% of the total variation,followed by the syndrome of qi deficiency and phlegm accumulation(account for 20.00%),the syndrome of liver-qi stagnation and spleen deficiency(account for 18.57%),the syndrome of phlegm-fire disturbing heart(account for 5.71%)and the syndrome of intense heat of Yang Ming(account for 5.71%)in turn. Conclusion:Qi stagnation,blood stasis and phlegm accumulation are the major syndrome elements of first-episode schizophrenia in clinic.关键词：first-episode schizophrenia;Chinese medical syndrome;objectification study
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发布时间：2022-08-31 - 摘要：Objective:Through the objective description of dynamic and kinematic parameters of cervical lifting manipulation, to provide data support for standardized operation of lifting manipulation. Methods30 male patients aged 18-36 years old with cervical spondylosis of neck type were selected. The cervical lifting manipulation was implemented by a senior massage physician. The dynamic and kinematic parameters of the performer during the lifting manipulation process were collected by force platform and high speed motion capture test system for infrared light spot. Results:①At the moment of cervical lifting,there was statistically significant difference on the force value between the left and right foot in performer(P<0.05),and there was statistically significant difference between the increase value of plantar force in performer and the decrease value of plantar force in patient(P<0.05). ②At the moment of cervical lifting,the resultant velocity of right elbow joint in performer was maximum,followed by right shoulder,knee and wrist in turn. For the comparisons of resultant velocity and resultant acceleration in performer,there were statistically significant differences between the right elbow and other joints,right wrist and other joints(P<0.05),but there were no statistically significant differences between the right knee and other joints,right shoulder and other joints(P>0.05). Conclusion:①At the moment of cervical lifting,the performer makes the force on both feet and mainly depends on the right foot. ②The resultant acceleration is one of the factors that affect the conversion between the increase force of performer and the decrease force of patient. ③The cervical lifting manipulation mainly depend on the elbow and combine with the knee,shoulder and waist joint to make overall coordination force. ④Before the lifting manipulation,the neck of the patient is firmly fixed by the right elbow and shoulder of the performer,which could make the overall force.关键词：lifting manipulation;neck;dynamic parameters;kinematic parameters;operation characteristics
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发布时间：2022-08-31 - 摘要：This paper discusses Wang Lingtai’s clinical experience in the treatment of chronic liver diseases with “Gan Ba Wei Recipe”(eight Chinese medicines for liver diseases). It considered that the pathogenesis is deficiency of vital qi and pathogenic toxin invasion. The treatment should benefit qi and promote blood circulation for removing obstruction in collaterals,invigorate spleen for softening liver and tonify kidney,clear heat-toxicity and resolve hard mass,harmonize yin and yang. The commonly used drugs include Lu Dangshen(Radix Codonopsis),Sheng Dihuang(Radix Rehmanniae Recens),Chuan Shihu(Herba Dendrobii),stir-fried Biejia(Carapax Trionycis),complete Danggui(Radix Angelicae Sinensis),Yinyanghuo(Herba Epimedii),fried Baizhu(Rhizoma Atractylodis Macrocephalae)and Huzhang(Rhizoma Polygoni Cuspidati). One proven case is presented.关键词：chronic liver diseases;“Gan Ba Wei Recipe”(eight Chinese medicines for liver diseases);clinical experience;Wang Lingtai
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发布时间：2022-08-31 - 摘要：This paper introduces Professor Cheng Jiazheng’s clinical experience in treating pediatric chronic diarrhea by therapy of invigorating spleen for eliminating dampness. He considers that the spleen deficiency and intense dampness are the key factors of onset and repeated attacking in pediatric chronic diarrhea. He emphasizes the therapy of invigorating spleen for eliminating dampness as the principle for treating root causes,and puts forward the therapy of invigorating spleen and nourishing stomach as the basic treatment for pediatric chronic diarrhea. Meanwhile the treatment should pay attention to the therapy of benefiting qi and nourishing yin,reinforcing kidney yang,warmly invigorating spleen and kidney, which strengthen vital qi and enhance resistance. The treatment could be combined with external application of Chinese medicine. One proven case is presented.关键词：chronic diarrhea;pediatric disease;invigorating spleen for eliminating dampness;experience of famous doctor;Cheng Jiazheng
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发布时间：2022-08-31 - 摘要：This paper introduces Professor Zhou Mingxin’s characteristics of compatibility with drug combination units. The concept,source,efficacy and features of drug combination units are explained. It is considered that the drug combination units should cautiously grasp the pathogenesis,and the reasonable connected formulations of drug combination units with different types are regarded as the compatibility characteristics. The composition and clinical application rules of commonly used drug combination units and connected formulations are illustrated combined with examples.关键词：drug combination units;prescription compatibility;clinical experience;Zhou Mingxin
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发布时间：2022-08-31 - 摘要：The experience in medication according to the syndrome differentiation and disease location differentiation are introduced in the syndrome of edema,fluid retention,pain,qi deficiency,phlegm turbid,blood stasis and blood deficiency. It is considered that the medication according to disease location differentiation is based on the syndrome differentiation and similar to disease differentiation,which refers to the different treatment for the same syndrome. It is an important supplement of treatment based on syndrome differentiation.关键词：Shanghan Lun(Treatise on Cold Pathogenic Diseases);disease location;syndrome differentiation;disease differentiation
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发布时间：2022-08-31 - 摘要：This paper discusses the internal connection between cold pathogenic diseases and miscellaneous diseases,including the primary and secondary,similarities and differences,separation and reunion in the syndrome and treatment. The cold pathogenic diseases are the former and the miscellaneous diseases are the latter. The general rules of cold pathogenic diseases are primary,and the various management of miscellaneous diseases are secondary. The syndrome and treatment of six meridians in cold pathogenic diseases provide the basic rules,and the syndrome and treatment of miscellaneous diseases reflect the flexibility in clinical practice,which suggest that the syndrome and treatment of cold pathogenic and miscellaneous diseases are consistent in essence. There are also miscellaneous diseases in the syndrome and treatment of six meridians in cold pathogenic diseases,and the treatment for miscellaneous diseases are also based on the syndrome and treatment of six meridians in cold pathogenic diseases,so Shanghan Lun(Treatise on Cold Pathogenic Diseases)and Jingui Yaolve(Synopsis of Golden Chamber)only just present the different emphases in the problem analysis.关键词：miscellaneous diseases;cold pathogenic diseases;primary and secondary;similarities and differences;separation and reunion
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发布时间：2022-08-31 - 摘要：This paper explores and investigates Zhang Yuansu’s treatise on the spleen and stomach in Yixue Qi Yuan(Medicine Origin)from the physiological features of spleen and stomach,syndrome differentiation and treatment of spleen and stomach diseases. Based on the achievements of many physicians and combined with his clinical experience,Zhang Yuansu founded the system of syndrome differentiation of zang-fu viscera,and had the unique thoughts on the physiological features of spleen and stomach,syndrome differentiation and treatment of spleen and stomach diseases,which formed his own spleen and stomach views. They include:the physiological view that spleen is the mother of all things and stomach is the root of human being；the syndrome differentiation view that taking the cold,heat,deficiency and excess of spleen and stomach as the principles；treatment view that treating spleen and stomach diseases by prescription formulation for dampness and basing on nourishing stomach qi. Spleen disease should eliminate dampness,and the drug selection and prescription formulation should take reinforcing and reducing methods in combination,which refer to the application of drugs with sweet or bitter flavor according to the qi movement of spleen and stomach.关键词：Zhang Yuansu;Yixue Qi Yuan(Medicine Origin);spleen and stomach views
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发布时间：2022-08-31 - 摘要：This paper discusses the syndrome and treatment characteristics of diabetes in Qianjin Fang(Recipes Worth A Thousand Gold)and its influence on later generations. It is considered that Sun Simiao’s diagnosis and treatment are based on fire. He often used the simple recipe and small compound recipe,and emphasized dryness-heat as the root cause. He often medicated with large dose and used heavy prescriptions for severe and lingering illness,which combined with assistant drugs for protecting spleen and stomach. Tianhuafen(Radix Trichosanthis),Huanglian(Rhizoma Coptidis) and Zhimu(Rhizoma Anemarrhenae) are applied with high frequency,which lays the foundation for the treatment of diabetes in later generations,and points out the direction of medication.关键词：Sun Simiao;Qianjin Fang(Recipes Worth A Thousand Gold);consumptive thirst;diabetes;dryness-heat;fire
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发布时间：2022-08-31 - 摘要：Objective:To observe the clinical efficacy of modified Shuanglu Recipe combined with Shenqi Dihuang Decoction in the treatment of IgA nephropathy proteinuria with deficiency of both qi and yin. Methods58 cases of IgA nephropathywith deficiency of both qi and yin were selected. By a randomized,single blind and cross-over study,the patients were randomly divided into the group A and group B,29 cases in each group. The group A was treated with the modified Shuanglu Recipe combined with Shenqi Dihuang Decoction for one course,the discontinue medication was performed for 2 weeks and then the patients were given the Shenqi Dihuang Decoction for one course. The group B was treated with Shenqi Dihuang Decoction for one course,the discontinue medication was performed for 2 weeks and then the patients were given the modified Shuanglu Recipe combined with Shenqi Dihuang Decoction. 8 weeks was taken as one course. The clinical efficacy and medication safety were observed,the changes on Chinese medical syndrome score,related biochemical indexes(24 hours urinary protein quantitation,liver and kidney function and humoral immune indicators)were compared. Results:①The total effective rates were 61.54% in the treatment group and 38.46% in the control group. There was statistically significant difference on the clinical efficacy between the two groups,and the efficacy of the treatment group was obviously better than that of the control group(P<0.05). ②In both groups,there was statistically significant difference on the Chinese medical syndrome score between treatment before and after(P<0.05). After treatment,there was statistically significant difference on the Chinese medical syndrome score between the two groups,and the score of the treatment group was obviously lower than that of the control group(P<0.05). ③After treatment,there was statistically significant difference on the level of 24 hours urinary protein quantitation between the two groups,the level in the treatment group was obviously lower than that in the control group(P<0.05). There were no statistically significant differences on the levels of serum creatinine(Scr),blood urea nitrogen(BUN),albumin(ALB),alanine aminotransferase(ALT),aspartate aminotransferase(AST)and red blood cells(RBC)between the two groups(P>0.05). ④In both groups,there was statistically significant difference on the level of IgE between treatment before and after(P<0.05),but there were no statistically significant differences on the other indicators between treatment before and after(P>0.05). After treatment,there were no statistically significant differences on the levels of all humoral immune indicators between the two groups(P>0.05). Conclusion:Modified Shuanglu Recipe combined with Shenqi Dihuang Decoction shows good efficacy in the treatment of IgA nephropathy proteinuria with deficiency of both qi and yin,which can more effectively reduce the proteinuria and protect the renal function of patients.关键词：chronic nephritis;proteinuria;modified Shuanglu Recipe;Shenqi Dihuang Decoction;reinforcing yin from yang
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发布时间：2022-08-31 - 摘要：Objective:To discuss the efficacy of therapy of warming yang and promoting blood circulation in the treatment of metformin-induced diabetic peripheral neuropathy(DPN)due to Vit B12 deficiency. Methods178 DPN patients were randomly divided into the control group and observation group,89 cases in each group. The control group was treated with methylcobalamin,and the observation group was treated with the therapy of warming yang and promoting blood circulation based on the treatment for the control group,with a course of 4 weeks. The clinical efficacy was observed in both groups,and the changes on the serum levels of Vit B12,methyl malonic acid(MMA),holotranscobalamin(holoTC),homocysteine(Hcy),anemia related indicators and nerve conduction velocity were compared before and after treatment. Results:①The clinical total effective rates were 78.65% in the control group and 91.01% in the observation group. The clinical efficacy of the observation group was obviously better than that of the control group(P<0.05). ②After treatment,the serum levels of Vit B12 and holoTC were increased(P<0.05)and the serum levels of MMA and Hcy were decreased(P<0.05)in both groups compared with treatment before,and the serum levels of Vit B12 and holoTC in the observation group were higher than those in the control group(P<0.05),the serum levels of MMA and Hcy in the observation group were lower than those in the control group(P<0.05). ③After treatment,the serum levels of hemoglobin(Hb)and ferritin were increased(P<0.05)and the serum level of mean corpuscular volume(MCV)was decreased(P<0.05)in both groups compared with treatment before,and the serum levels of Hb and ferritin in the observation group were higher than those in the control group(P<0.05),the serum level of MCV in the observation group was lower than that in the control group(P<0.05). ④After treatment,the sensory conduction velocity (SCV) and motor conduction velocity (MCV) in median nerve and tibial nerve were increased in both groups(P<0.05),and the SCV and MCV of patients in the observation group were faster than those in the control group(P<0.05). Conclusion:The therapy of warming yang and promoting blood circulation can improve the metformin-induced Vit B12 deficiency in the treatment of diabetic peripheral neuropathy.关键词：Vitamin B;12;deficiency;diabetic peripheral neuropathy;therapy of warming yang and promoting blood circulation;metformin
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发布时间：2022-08-31 - 摘要：Objective:To observe the distribution of positive reaction points in dorsal segment of governor meridian in patients with gastroesophageal reflux disease(GERD)and the efficacy of acupuncture for dredging governor meridians and guiding qi movement in the treatment of this disease. MethodsBefore treatment,60 GERD patients were selected,the positive reaction points were detected at spinous process in dorsal segments T1-T12 of governor meridian and recorded. According to the positive reaction points,the acupuncture therapy was performed. The changes on the scores of reflux disease questionnaire(RDQ),Zung self-rating anxiety scale(SAS)and Zung self-rating depression scale(SDS)were observed before and after treatment. Results:①In 60 cases,there were 50 patients with simple tenderness,5 patients with simple nodule,3 patients with tenderness and nodule. The positive rate was 96.67%. ②The distribution of positive reaction points showed the tendency of high in the middle and low at both ends. The curve reached the peak in the segments T5 and T7,and the left slope of peak was smaller than right slope. The segments T1 and T9 were approximately at the same level,and the frequency of the segments T10-T12 were relatively lower. ③For the distribution of pain degree at tenderness points,the distribution curve of moderate and severe pain showed the tendency of high in the middle and low at both ends. The curve reached the peak in the segments T5-T7,and the severe pain mainly concentrated in the segments T3-T9. ④Compared with treatment before,the scores of RDQ,SAS and SDS were obviously decreased after treatment,with statistically significant differences(P<0.05). Conclusion:The positive reaction points in dorsal segments T3-T9 of governor meridian could be used for auxiliary diagnosis of GERD. Taken the positive reaction points as the therapeutic acpoints,combined with acupuncture for dredging governor meridians and guiding qi movement,the treatments can not only improve the reflux symptoms of patients,but also significantly improve the mental and psychological state.关键词：gastroesophageal reflux disease;governor meridian;positive reaction points;acupuncture for dredging governor meridians and guiding qi movement
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发布时间：2022-08-31 - 摘要：Objective:To observe the effects of six-word common health Qigong on the electroencephalogram(EEG) of patients with mild cognitive impairment. Methods60 patients with mild cognitive impairment(MCI)were randomly divided into the treatment group and control group,30 cases in each group. The patients in the treatment group taken the six-word common health Qigong exercises for 3 months,and the patients in the control group did not take exercise. Before exercise,after exercise for one and three months,the changes on the score of mini mental state examination(MMSE)scale and the EEG in task state were detected. Results:①In both groups,there was no statistically significant difference on the MMSE score between the treatment before and after exercise for one month(P>0.05). In the treatment group,there was statistically significant difference on the MMSE score between the treatment before and after exercise for three months(P<0.05). After exercise for three months,there was statistically significant difference on the MMSE score between the two groups,and the score of the treatment group was obviously higher than that of the control group(P<0.05).②For the comparison between the treatment before and after exercise for one month,the difference on the approximate entropy of EEG was not statistically significant in the control group(P>0.05). Compared with treatment before,the EEG approximate entropy was obviously decreased in the treatment group after exercise for one month(P<0.05)；and the EEG approximate entropy was obviously decreased in the treatment group after exercise for three months(P<0.05). After exercise for one month,the EEG approximate entropy in the treatment group was obviously lower than that in the control group(P<0.05). After exercise for three months,there was statistically significant difference on the EEG approximate entropy between the two groups,and the EEG approximate entropy in the treatment group was obviously lower than that in the control group(P<0.05).③For the comparison between the treatment before and after exercise for one month,the difference on the LZ complexity of electroencephalogram was not statistically significant in the control group(P>0.05). Compared with treatment before,the LZ complexity of electroencephalogram was obviously decreased in the treatment group after exercise for one month(P<0.05)；and the LZ complexity of electroencephalogram was obviously decreased in the treatment group after exercise for three months(P<0.05). After exercise for one month,the LZ complexity of electroencephalogram in the treatment group was obviously lower than that in the control group(P<0.05). After exercise for three months,there was statistically significant difference on the LZ complexity of electroencephalogram between the two groups,and the LZ complexity of electroencephalogram in the treatment group was obviously lower than that in the control group(P<0.05). Conclusion:The six-word common health Qigong can significantly delay the disease progression of patients with mild cognitive impairment and improve the memory. Its positive effect on brain function can be objectively proved by some indicators(approximate entropy and LZ complexity)in the electroencephalogram.
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发布时间：2022-08-31 - 摘要：Objective:To observe the clinical efficacy of“Qi’s No.1 Recipe for uterine cavity”combined with hysteroscopy in the treatment of embryo recurrent implantation failure caused by intrauterine adhesions. Methods71 patients with embryo recurrent implantation failure caused by intrauterine adhesions(total 97 transplant cycles) were randomly divided into the treatment group(35 cases with 47 transplant cycles)and control group(36 cases with 48 transplant cycles). Both groups underwent the hysteroscopic intrauterine adhesions dissection and insertion of intra-uterine device. The treatment group was additionally treated with“Qi’s No.1 Recipe for uterine cavity”,and the control group was taken as the blank control. After 2 menstrual cycles,both groups were performed the hysteroscopy again and the intrauterine device was taken out. The transplant cycle got in the next month.The degree of intrauterine adhesions,endometrial thickness and related indicators of clinical pregnancy outcome were observed. Results:①In both groups,there was statistically significant difference on the degree of intrauterine adhesions between treatment before and after(P<0.05). After treatment,the improvement on intrauterine adhesions in the treatment group was slightly better than that in the control group,but with no statistically significant difference(P>0.05). ②On the day of implantation,there was no statistically significant difference on the endometrial thickness between the two groups(P>0.05). ③After treatment,the implantation rates were 25.0% in the treatment group and 8.0% in the control group,there was statistically significant difference on the implantation rate between the two groups(P<0.05). The biochemical pregnancy rates were 42.6% in the treatment group and 14.6% in the control group,there was statistically significant difference on the biochemical pregnancy rate between the two groups(P<0.05). The clinical pregnancy rates were 27.7% in the treatment group and 10.4% in the control group,there was statistically significant difference on the clinical pregnancy rate between the two groups(P<0.05). ④The abortion rates were 31.6% in the treatment group and 44.4% in the control group,there was no statistically significant difference on the abortion rate between the two groups(P>0.05). The ectopic pregnancy rates were 0.0% in the treatment group and 2.1% in the control group,there was no statistically significant difference on the ectopic pregnancy rate between the two groups(P>0.05). Conclusion:“Qi’s No.1 Recipe for uterine cavity”combined with hysteroscopy can improve the implantation rate and clinical pregnancy rate in patients with embryo recurrent implantation failure caused by intrauterine adhesions. Its mechanism may be associated with the improvement on endometrial blood supply.关键词：intrauterine adhesions;Asherman syndrome;recurrent implantation failure;test-tube baby;nourishing kidney and activating blood;hysteroscope
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发布时间：2022-08-31 - 关键词：reinforcing and protecting yang qi;exogenous cough;acne;somnolence;clinical experience
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发布时间：2022-08-31 - 摘要：This paper discusses the effect of Ziwan(Radix Asteris)on nourishing kidney and promoting urination and defecation. Radix Asteris is of pungent flavour and moistening function,it could disperse lung qi and descend the lower qi,regulate the fluid passage and benefit the peristalsis of large intestine,which shows the effects of promoting urination and defecation.关键词：Radix Asteris;nourishing kidney;constipation;dysuria
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发布时间：2022-08-31 - 摘要：Objective:To observe the immune regulatory effects of astragaloside IV on spleen derived Th1 and Th2 cells in ovalbumin(OVA)induced asthmatic mice. MethodsThe OVA-induced mouse asthma model was established. The spleen mononuclear cells were isolated and cultured and intervened by astragaloside IV at different concentrations. The expression levels of cytokines including IFN-γ,IL-4 and IL-13 in the supernatant of cell culture medium were detected by enzyme linked immune sorbent assay (ELISA),and the percentage of IFN-γ,IL-4 and IL-13 within mononuclear cells were detected by flow cytomentry. Results:Astragaloside IV at the concentrations of 25,50 and 100 mg/L showed certain inhibitory effects on the cytokines(IFN-γ,IL-4 and IL-13)secreted by Th cell subsets in OVA-induced asthmatic mice(P<0.05). Conclusion:Astragaloside IV shows the inhibitory effects on OVA-induced Th2 cell response,and its immune regulation effects may be associated with the inhibition on Th1 and Th2 cells.关键词：Astragaloside IV;immune regulation;experiment in vitro;Th cell subsets
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发布时间：2022-08-31 - 摘要：Objective:To observe the anti-inflammation and anti-oxidation effects of “Jianpi Bushen Lishi Recipe ” in hyperuricemia nephropathy rats. MethodsThe model of hyperuricemia nephropathy was made by yeast dry powder and adenine in SD rats,and the normal rats were taken as the blank group. After successful modeling,the rats were randomly divided into the model group,Jianpi Bushen Lishi Recipe group and allopurinol group. Each group was treated with the corresponding drugs for 8 weeks. The levels of blood uric acid(BUA),serum creatinine(SCr)and blood urea nitrogen(BUN)were detected. The serum levels of IL-6 and TNF-α were detected by ELISA. The activities of superoxide dismutase (SOD),glutathione peroxidase (GSH-PX) and catalase (CAT) were detected by xanthine oxidase method,DTNB direct coloration and visible spectrophotometry,respectively. The content of malondialdehyde (MDA) was detected by thiobarbituric acid(TBA)method. Results:There were statistically significant differences on all indicators between the blank group and model group(P<0.05,P<0.01).Compared with the model group,the levels of BUA,SCr,BUN,IL-6 and TNF-α were decreased in the Jianpi Bushen Lishi Recipe group,and the activities of GSH-PX,SOD and CAT were increased and the content of MDA was decreased,with statistically significant differences(P<0.05).Compared with the allopurinol group,the levels of BUA,SCr,BUN,IL-6 and TNF-α were decreased in the Jianpi Bushen Lishi Recipe group,and the activity of GSH-PX was increased and the content of MDA was decreased,with statistically significant differences(P<0.05). There were no statistically significant differences on the activities of SOD and CAT between the allopurinol group and Jianpi Bushen Lishi Recipe(P>0.05). Conclusion:Jianpi Bushen Lishi Recipe shows good anti-inflammation and anti-oxidation effects,which can positively affect the micro-inflammation and oxidative stress in hyperuricemia nephropathy rats.关键词：hyperuricemia nephropathy;Jianpi Bushen Lishi Recipe;micro-inflammation;oxidative stress
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发布时间：2022-08-31 - 摘要：Objective:To observe the preventive and therapeutic effects of Zishen Qingqi(ZSQQ)Granule on inflammation in collagen-induced arthritis mice. MethodsDBA/1 mice were randomly divided into the normal group,model group,methotrexate group and ZSQQ groups with low-,middle- and high-dose. Except the normal group,the mice model of collagen-induced arthritis was established in the other groups. From the same day of induction,each group was treated with the corresponding drugs for continuous 3 weeks. The arthritis index was evaluated. The scores on inflammatory mediators and bone destruction in the pathological sections of mouse joint were observed. The serum level of anti-collagen type Ⅱ (CⅡ) specific antibody was detected by ELISA. Results:Compared with the model group,the arthritis index was effectively decreased in the ZSQQ groups with low-,middle- and high-dose,with statistically significant differences(P<0.05). Compared with the model group,the serum antibody titer of anti- CⅡ was effectively decreased in the ZSQQ group with high-dose,with statistically significant difference(P<0.05). The scores on inflammatory mediators and bone destruction in the ZSQQ groups with low-,middle- and high-dose were all lower than those in the model control group(P<0.05). Conclusion:Zishen Qingqi Granule Shows the preventive and therapeutic effects in collagen-induced arthritis mice. Its mechanism maybe associated with the decrease in serum level of specific anti-CⅡ antibody in arthritis mice.关键词：Zishen Qingqi Granule;collagen-induced arthritis;systemic lupus erythematosus;anti-inflammation
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发布时间：2022-08-31 - 摘要：Objective:To discuss the influence of Shiquan Dabu Decoction and its separated recipe Sijunzi Decoction on the metastatic tumor growth and natural killer(NK)cells in BALB/c mice transplanted with CT-26 colon carcinoma after resection of primary tumor,and study the possible mechanism. MethodsThe subcutaneous metastatic tumor model of CT-26 colon carcinoma was established in BALB/c mice. The mice were randomly divided into the un-resection group of primary tumor,resection group of primary tumor,Shiquan Dabu Decoction group and Sijunzi Decoction group,12 mice in each group. From 5 days before the operation,the mice in the un-resection group and resection group were treated with 0.9% NaCl solution by intragastric administration,each mice in the Shiquan Dabu Decoction group were treated with Shiquan Dabu Decoction at dose of 0.52 g,each mice in the Sijunzi Decoction group were treated with Sijunzi Decoction at dose of 0.18g,with a course of continuous 2 weeks. Except the un-resection group,the resection of primary tumor was performed in the other groups. The expression of adhesion molecule CD49b in metastatic tumor was detected by Supervision immunohistochemistry. The percentage of NK cells expressing CD49b and CD335 in peripheral blood lymphocytes were measured by flow cytometry. Results:The incidence rate of metastatic tumor was 75% in the resection group,58% in the un-resection group,42% in the Shiquan Dabu Decoction group and 58% in the Sijunzi Decoction group. 2 weeks after operation,the weight of metastatic tumor in the Shiquan Dabu Decoction group was obviously lower than that in the un-resection group and resection group ,with statistically significant differences(P<0.05),but no significant effect on the weight of metastatic tumor was observed in the Sijunzi Decoction group. The volume of metastatic tumor in the Shiquan Dabu Decoction group [(1 546.79±242.13)mm3] and Sijunzi Decoction group [(2 079.24±234.10)mm3] was significantly lower than that in the un-resection group [(2 412.98±230.42)mm3] and resection group [(3 065.06±317.02)mm3],with statistically significant differences(P<0.01).The proportion of CD49b expressing NK cells in peripheral blood was(20.63±2.99)% in the un-resection group,(22.74±1.05)% in the resection group,(34.34±3.77)% in the Shiquan Dabu Decoction group and(28.50±1.65)% in the Sijunzi Decoction group. The proportion was obviously increased in the Shiquan Dabu Decoction group and Sijunzi Decoction group,with statistically significant differences(P<0.05).The proportion of CD335 expressing NK cells in peripheral blood was(2.19±0.69)% in the un-resection group,(1.90±0.21)% in the resection group,(3.21±0.19)% in the Shiquan Dabu Decoction group and(2.36±0.26)% in the Sijunzi Decoction group. The proportion was obviously increased in the Shiquan Dabu Decoction group,the difference was statistically significant compared with the other groups(P<0.05).The results of immunohistochemistry showed that the CD49b expression in the metastatic tumor in the Shiquan Dabu Decoction group was significantly higher than that in the other groups(P<0.05). Conclusion:The resection of primary tumor can inhibit the function of NK cells and down-regulate the expressions of CD49b and CD335,which is beneficial to tumor cell escape and growth. Shiquan Dabu Decoction can significantly inhibit the growth of metastatic tumors after resection of primary tumor,which may be associated with the up-regulation of CD49b and CD335 expressions.关键词：Shiquan Dabu Decoction;Sijunzi Decoction;tumor;metastasis;NK cells
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发布时间：2022-08-31 - 摘要：Objective:To study the effects of Kangzhi Recipe on regulating glucose and lipid metabolism and improving nonalcoholic steatohepatitis. MethodsSD rats were randomly divided into the normal control group,model group of steatohepatitis,Yishanfu Capsule(polyene phosphatidylcholine capsules)group and Kangzhi Recipe group. Except the normal control group,the other groups were fed with high fat diet and treated with CCl4 by subcutaneous injection to establish the model. During the modeling,each group was treated with the corresponding drugs by intragastric administration for 8 weeks. The liver function,biochemical indexes,pathological staining of liver tissue and homeostasis model assessment for insulin resistance (HOMA-IR) were routinely detected. The levels of adiponectin (ADP/Acrp3),peroxisome proliferator-activated receptor-α (PPAR-α), tumor necrosis factor-α (TNF-α),fasting insulin (FINS),free fatty acid (FFA) and protein tyrosine kinase (PTK) were detected by ELISA. The expressions of related proteins in insulin signaling pathway were detected by Western blotting. Results:Compared with the model group of steatohepatitis,the liver function of rats with nonalcoholic steatohepatitis were obviously improved in the Kangzhi Recipe group,and the related pathological characteristics and biochemical indexes were reversed,with statistically significant differences(P<0.05,P<0.01). And after the treatment of Kangzhi Recipe,the levels of fasting plasma glucose(FPG),FINS and HOMA-IR were decreased(P<0.01),the contents of PTK,PPAR-α and ADP were increased(P<0.01)and the content of TNF-α was decreased(P<0.01),the protein expression of insulin receptor(IR)was increased(P<0.01)and the protein expressions of insulin receptor substrate 1(IRS1)and IRS2 were increased(P<0.05),the expressions of PI3K and phosphorylated Akt were obviously increased(P<0.05)and the expression of phosphorylated p38 was obviously decreased(P<0.01). It suggested that the sensitivity of rat hepatocytes to insulin was increased and the insulin signaling transduction was improved. Conclusion:Kangzhi Recipe can significantly improve nonalcoholic steatohepatitis. Its mechanism may be associated with the regulation on hepatic glucose and lipid metabolism and improvement on insulin signaling pathway.关键词：Kangzhi Recipe;nonalcoholic steatohepatitis;glucose and lipid metabolism
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发布时间：2022-08-31 - 摘要：This paper reviews the research progress on immune mechanism of Chinese medicine in the prevention and treatment of hypertension and its target organ damage. The imbalance of immune regulation function and it mediated persistent chronic inflammatory response have become one of the new topics in the hypertension mechanism research.The imbalance of immune regulation in hypertension mainly involve the nonspecific immunity,specific immunity,regulation of autonomic nervous system on immune response and other aspects. Chinese medicine could play a role in the prevention and treatment of hypertension and its target organ damage by above immune pathway.关键词：hypertension;immune regulation;review
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发布时间：2022-08-31 - 摘要：This paper reviews the role of cAMP response element binding protein (CREB) signaling pathway in therapy of traditional Chinese medicine on cognitive impairment. CREB is closely related to neuronal generation,synaptic plasticity,learning and memory. Many signal transduction pathways within nerve cells can converge and involve in the induction of CREB activation. Multiple signal transduction pathways,such as cyclic adenosine monophosphate(cAMP)signaling pathway,phosphoinositide-3-kinase/ protein kinase B(PI3K/Akt)signaling pathway,p38 mitogen-activated protein kinase(p38MAPK)and calcium/ calmodulin-dependent protein kinaseⅡ(Ca2+-CAMKⅡ),can mediate the phosphorylation of CREB,which make the CREB signaling pathway and its related molecules become the drug targets in the treatment of cognitive impairment.关键词：cognitive impairment;CREB signaling pathway;therapy of traditional Chinese medicine;mechanism;review
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发布时间：2022-08-31
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