最新刊期
期 10 ， 2017
- 摘要：This paper introduces Professor Shi Qi’s clinical experience in the treatment of lumber intervertebral disc herniation. He proposes the therapy of promoting blood circulation for removing blood stasis and obstruction in collaterals in initial stage,therapy of benefiting qi for removing blood stasis in middle stage and therapy of invigorating liver and kidney in advanced stage. It is considered that the treatment of lumber intervertebral disc herniation should pay attention to dimensional thinking analysis,which include not only the oral administration but also the external application of Chinese medicine. It could combine with the therapy of ear acpoints pressure,three steps and nine methods of waist manipulation,twelve-word health maintenance exercise and sacral canal block.
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发布时间：2022-08-31 - 摘要：This paper introduces Professor Lu Jin’gen’s clinical experience in the treatment of diarrhea-related diseases, such as ulcerative colitis, Crohn’s disease, proctitis, irritable bowel syndrome with diarrhea, ileocecal inflammation, radiation enteritis and so on. It is considered that the pathogenesis is complicated with numerous related factors. He puts forward some treatment principles,such as clearing heat and cooling blood,benefiting qi and nourishing yin,regulating qi-flowing for dredging collateral,softening liver and strengthening spleen and so on. Taken the concept of holism as the core in treatment,he proposes the treatments according to different disease and different stage for all kinds of diarrhea. And one proven case is presented.关键词：diarrhea;experience of famous doctor;Lu Jin’gen
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发布时间：2022-08-31 - 摘要：This paper discusses the syndrome and treatment of distention and fullness due to depression syndrome.Distention and fullness due to depression syndrome mainly refers to gastric stuffiness and abdominal fullness triggered or aggravated by emotional factors.Its pathogenesis involve qi depression without pathogen,stagnation and visibility,and also can be food retention,phlegm stagnation,blood stasis or deficiency of qi and blood caused by stagnant qi movement. Apart from the spleen-stomach disorder,its clinical manifestations also can be accompanied by various symptoms. Its patterns include single depression syndrome and the coexistence of diseases and depression syndrome. It can be treated based on relieving depression or both on depression and diseases. The principles of treatment based on relieving depression include dispersing stagnated liver qi and regulating qi-flowing for eliminating stuffiness,activating spleen for eliminating dampness,dissipating phlegm and removing food stagnation. Identifying whether distention and fullness is induced by depression syndrome should refer to laboratory test.Distention and fullness due to depression syndrome is similar to functional dyspepsia,functional abdominal distention,aerophagia,irritable bowel syndrome,functional constipation or other functional gastrointestinal disorders correlated with psychological factors,or depression,anxiety,somatization disorder or other mental disorders.The theory and practice of distention and fullness due to depression syndrome in the diagnosis and treatment have got more and more support by modern medicine.关键词：depression syndrome;gastric stuffiness;abdominal fullness;etiology and pathogenesis;diagnosis;treatment
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发布时间：2022-08-31 - 摘要：Objective:To discuss the relationships between serum inflammatory factors and constitution of Chinese medicine or syndrome differentiation and classification in community patients with mild cognitive impairment. Methods118 community patients with mild cognitive impairment were included. The constitutional types of Chinese medicine were differentiated according to the relevant standards in Classification and Judgement of Constitutions of Chinese Medicine,and syndrome differentiation and pattern classification of Chinese medicine were preformed based on the relevant standards in Guidelines for Clinical Research of Chinese Medicine New Drugs. The levels of inflammatory factors IL-1β and IL-6 were detected by ELISA. The differences on the levels of IL-1β and IL-6 between different constitutional type and syndrome patterns were compared. Results:①In 118 community patients with mild cognitive impairment,there were 65 cases in normal constitution(accounted for 55.1%),25 cases in yang deficiency constitution(accounted for 21.2%)and 28 cases in other biased constitutions(accounted for 23.7%). ②In 118 community patients with mild cognitive impairment,there were 49 cases with syndrome of deficiency of spleen and kidney(accounted for 41.5%),18 cases with syndrome of hyperactivity of yang due to yin deficiency(accounted for 15.3%),17 cases with syndrome of deficiency of qi and blood(accounted for 14.4%)and 34 cases with other syndrome patterns(accounted for 28.8%). ③There were statistically significant differences on the levels of IL-1β and IL-6 between normal constitution group and other constitutions group(P<0.05,P<0.01). There were statistically significant differences on the levels of IL-1β and IL-6 between patients with syndrome of deficiency of spleen and kidney and patients with other syndrome patterns(P<0.05). Conclusion:In community patients with mild cognitive impairment,the most common constitutional type of Chinese medicine is normal constitution and the syndrome of deficiency of spleen and kidney is the main pattern in syndrome differentiation of Chinese medicine. The levels of IL-1β and IL-6 in patients with normal constitution are higher than those in patients with other constitutions,and the levels of IL-1β and IL-6 in patients with syndrome of deficiency of spleen and kidney are lower than those in patients with other syndrome patterns.关键词：community mild cognitive impairment;constitution of Chinese medicine;syndrome differentiation and pattern classification;inflammatory factors
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发布时间：2022-08-31 - 摘要：This paper introduces Professor Qi Cong’s experience in the treatment of embryonic developmental arrest. It is considered that the root causes of this disease are deficiency of both kidney and spleen and stagnation of blood stasis. The treatment should warm channel and activate blood circulation to abort the fetus,and then regulate and nourish the congenital and acquired essence. She emphasizes preventing before the disease arises and preventing disease from exacerbation. One proven case is presented.关键词：embryonic developmental arrest;therapy of traditional Chinese medicine;experience of famous doctor;Qi Cong
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发布时间：2022-08-31 - 摘要：This article discusses Professor Zhou Yongming’s clinical experience in the treatment of common hemorrhagic diseases of hematological system.He puts forwards that the clinical practice should grasp the pathogenesis features of disease at different stages,and make clear differentiation of manifestations and root causes,deficiency and excess. The symptomatic treatment in acute condition and radical treatment in chronic case are performed. The pathogenesis features of hemorrhagic diseases are deficiency in origin and excess in superficiality,which mainly present deficiency of spleen and kidney as root cause and fire heat impairing collaterals as manifestation combined with internal stagnation of blood stasis and stagnation of liver qi. In concrete clinical treatment,as long as the principles of deficiency as root cause and fire heat as manifestation are held,the good efficacy could be achieved.关键词：hemorrhagic diseases;deficiency in origin and excess in superficiality;clinical experience;Zhou Yongming
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发布时间：2022-08-31 - 摘要：This paper introduces the thoughts and experience of Professor Liu Aihua in the treatment of diabetic nephropathy proteinuria. It is considered that the key to this disease are deficiency of spleen and kidney,dysfunction of spleen in ascending the clear and sinking of turbid toxin. And according to its etiology and pathogenesis,she puts forward the therapy principles of benefiting qi for strengthening kidney and ascending the clear and descending the turbid,and creates“Tangshen Shengqing Jiangzhuo Decoction”. The treatment of Chinese medicine according to disease and syndrome differentiation are flexibly applied,which could strengthen vital qi to eliminate pathogenic factor with deficiency and excess in combination and treat both manifestation and root cause of disease,and show good efficacy in clinic.关键词：diabetic nephropathy proteinuria;benefiting qi for strengthening kidney;ascending the clear and descending the turbid;theoretical discussion;experience of famous doctor;Liu Aihua
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发布时间：2022-08-31 - 摘要：This paper introduces Professor Jiang Zhiyan’s clinical experience in treating chronic cough in children from nose and spleen. He considers that the treatment for this disease should pay attention to treat nose,while treating nose should first regulate spleen. In the perspective of traditional Chinese and western medicine in combination,the reasons for treating chronic cough in children based on regulating nose and spleen are analyzed,and the commonly used prescriptions and drugs are elaborated. One proven case is presented.关键词：chronic cough in children;treatment from nose;treatment based on regulating spleen;invigorating spleen for resuscitation;arresting cough and removing phlegm
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发布时间：2022-08-31 - 关键词：infantile fever;syndrome differentiation of six meridians;Treatise on Cold Pathogenic Diseases
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发布时间：2022-08-31 - 摘要：This paper discussed the medical achievements on the differentiation and treatment of phlegm and fluid retention before Tang Dynasty. By studying the famous medical works before Tang Dynasty,it found that,the definition of phlegm and fluid retention was not clear in Inner Canon of Huangdi(Huangdi Neijing),which put forward the theory of water-fluid metabolism in zang-fu viscera and prescription rules of nature and flavour compatibility. The differentiation and treatment of phlegm and fluid retention were systematically summarized in Treatise on Cold Pathogenic and Miscellaneous Diseases(Shanghan Zabing Lun),which deeply involved principle-method-recipe-medicines. In General Treatise on Causes and Manifestations of All Diseases(Zhu Bing Yuan Hou Lun),the etiology and pathogenesis of phlegm and fluid retention in human body were systematically summarized. As to Recipes Worth A Thousand Gold(Qianjin Fang)and Arcane Essentials from the Imperial Library(Waitai Miyao Fang),the experience of medicines and prescriptions in the differentiation and treatment of phlegm and fluid retention before Tang Dynasty were widely collected,which enriched the academic system of differentiation and treatment of phlegm and fluid retention. Zhang Zhongjing created the systems of principle-method-recipe-medicines for differentiation and treatment of phlegm and fluid retention,which reached the highest level. Therefore,for the summary of medical achievements on the differentiation and treatment of phlegm and fluid retention before Tang Dynasty,it was necessary to perform the comparative study based on Zhongjing’s theory.关键词：phlegm and fluid retention;Inner Canon of Huangdi;Zhang Zhongjing;Sun Simiao;Wang Tao;Recipes Worth A Thousand Gold;Arcane Essentials from the Imperial Library;literature research
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发布时间：2022-08-31 - 摘要：By sorting out the medicines,prescriptions and their modification in Treatise on Spleen and Stomach(Piwei Lun)and Differentiation on Endogenous and Exogenous Diseases(Neiwai Shang Bianhuo),this paper investigates Li Dongyuan’s medicine-syndrome(symptom). According to the original text,the medicines are classified based on syndrome(symptom),listed one by one and then summed up and analyzed. The medicine-symptom(syndrome)mainly involve the head(including mental spirit),chest,lung,stomach,lateral thorax,abdomen,urine and stool,arthralgia,flaccidity disease,sweating and other symptoms(syndromes). The most distinctive features of symptomatic treatment with prescriptions and their modification in his two books are the combination of climate in four seasons,the transformation of deficiency,excess,cold and heat and the progressive medication.关键词：Li Dongyuan;Differentiation on Endogenous and Exogenous Diseases;Treatise on Spleen and Stomach;medicine-syndrome(symptom)
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发布时间：2022-08-31 - 摘要：This paper analyzes and summarizes the etiology,pathogenesis and treatment methods of emotional diseases in Confucians’ Duties to Parents(Rumen Shi Qin).It is considered that the emotional diseases are caused by deficiency of vital qi, adverse rising of yang qi liver qi invading spleen and disorder of qi movement. The psychotherapy and the spiritual desensitization therapy could be used in the treatment. Combined with modern psychology and the characteristics of modern psychological diseases,it suggests that the theory of emotion in Confucians’ Duties to Parents could enlighten the treatment of modern emotional diseases.关键词：Confucians’ Duties to Parents;Zhang Zihe;emotional diseases
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发布时间：2022-08-31 - 摘要：Objective:To observe the clinical efficacy of Xuefusheng Extract combined with associated prescriptions of syndrome differentiation in the treatment of chronic aplastic anemia and the influence on microRNA,lymphocyte subsets and cytokines in peripheral blood. Methods60 patients with chronic aplastic anemia were randomly divided into the treatment group and control group,30 cases in each group. Another 20 cases were included as the normal control group. The control group was treatedwith the routine basic treatment,and the treatment group was treated with Xuefusheng Extract combined with associated prescriptions of syndrome differentiation based on the treatment for the control group. The treatment course in both groups was 6 months with follow-up for 6 months. The clinical efficacy was observed,and the levels of hematological parameters in peripheral blood(including hemoglobin ,white blood count ,platelet count ,percentage of neutral granulocyte,percentage of lymphocytes and absolute count of reticulocyte ),the microRNA expressions(including miRNA-155-5p and miRNA-1260b) in peripheral blood mononuclear cells,the levels of lymphocyte subsets in peripheral blood(including the proportion of total T cells,B cells,NK cells,Th cells and Tc cells and the ratio of Th/Tc)and the levels of related cytokines in plasma(including interferon-γ,interleukin-12p70,tumor necrosis factor-α and transforming growth factor-β1)were detected and compared. Results:①The clinical total effective rates were 83.33% in the treatment group and 53.33% in the control group. The clinical efficacy of the treatment group was significantly better than that of the control group(P<0.05). ②After treatment,there were statistically significant differences on the levels of Hb,WBC and Ret between the two groups,and the levels of the treatment group were obviously higher than those of the control group(P<0.05). ③After treatment,there were statistically significant differences on the expression levels of miRNA-155-5p and miRNA-1260b between the treatment group and control group,and expression levels of the treatment group were obviously lower than those of the control group(P<0.05). Compared with the normal group before the treatment,the expression levels of miRNA-155-5p and miRNA-1260b were obviously up-regulated in both treatment and control group(P<0.05). Compared with the normal group after the treatment,the expression levels of miRNA-155-5p and miRNA-1260b were decreased in both treatment and control group,but not reach the normal level(P<0.05). ④After treatment,there were statistically significant differences on the proportion of NK cells,Th cells and Tc cells and the level of Th/Tc between the treatment group and control group(P<0.05). Compared with the normal group before the treatment,the proportion of NK cells and Th cells and the level of Th/Tc in both treatment and control group were obviously lower than those in the normal group(P<0.05),and the proportion of Tc cells in both treatment and control group was obviously higher than that in the normal group(P<0.05). After treatment,there was statistically significant difference on the level of Th/Tc between the treatment group and normal group,and the level of Th/Tc in the treatment group was lower than that in the normal group(P<0.05),while there were no statistically significant differences on the proportion of NK cells,Th cells and Tc cells between the treatment group and normal group(P>0.05). After treatment,there were statistically significant differences on the proportion of NK cells,Th cells and Tc cells and the level of Th/Tc between the control group and normal group,and all the proportion and level in the control group were not to the normal levels(P<0.05). ⑤After treatment,there were statistically significant differences on the levels of IFN-γ,IL-12p70,TNF-α and TGF-β1 between the treatment group and control group(P<0.05). Before treatment,there were statistically significant differences on the levels of IFN-γ,IL-12p70,TNF-α and TGF-β1 between the normal group and treatment or control group,and the levels of IFN-γ,IL-12p70 and TNF-α in the treatment and control group were obviously higher than those in the normal group(P<0.05),and the level of TGF-β1 in the treatment and control group was obviously lower than that in the normal group(P<0.05). After treatment,there were statistically significant differences on the levels of IFN-γ,TNF-α and TGF-β1 between the normal group and treatment or control group,and the levels of IFN-γ,TNF-α and TGF-β1 in the treatment and control group were not to the normal levels(P<0.05),while there was no statistically significant difference on the level of IL-12p70 between the normal group and treatment group,and the level of IL-12p70 in the treatment group recovered to the normal level(P>0.05). Conclusion:Based on the routine therapy of western medicine,Xuefusheng Extract combined with associated prescriptions of syndrome differentiation shows better efficacy in the treatment of chronic aplastic anemia. Its regulation mechanisms on abnormal immune in aplastic anemia may be associated with the improvement on imbalance of lymphocyte subsets,inhibition on hematopoietic negative regulators and down-regulation of miRNA-155-5p and miRNA-1260b expressions.关键词：chronic aplastic anemia;Xuefusheng Extract;invigorating kidney for replenishing essence;microRNA;lymphocyte subsets;cytokines
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发布时间：2022-08-31 - 摘要：Objective:To observe the clinical efficacy of acupuncture combined with auricular therapy and three-step analgesic ladder in the treatment of cancer pain. Methods120 patients with cancer pain were randomly divided into the treatment group and control group,60 cases in each group. Both groups were treated with the basic therapy of three-step analgesic ladder. Additionally,the treatment group was treated with acupuncture combined with auricular therapy,and the control group was treated with sham acupuncture and auricular therapy,with a course of 21 days. The usage and side reactions of analgesics in three-step ladder were observed,and the visual analogue scale(VAS)score,Zubrod performance status(ZPS)score and the levels of natural killer(NK)cells and T cells(CD3+,CD4+,CD8+,CD4+/CD8+)were compared. Results:①Finally 114 patients completed the whole trial,58 cases in the treatment group and 56 cases in the control group. ②After treatment,there was statistically significant difference on VAS score between the two groups,and the VAS score of the treatment group was obviously lower than that of the control group(P<0.05). ③At the end of the treatment,58.62% patients in the treatment group effectively reduced the analgesic usage or used the analgesics in lower ladder,while 17.86% patients in the control group did. There was statistically significant difference on the effective rate of drug reduction between the two groups(P<0.05). ④At the end of the treatment,the decrease on side reactions of analgesics was observed in 34.48% patients in the treatment group and 21.43% patients in the control group. There was statistically significant difference on the effective rate of side effects reduction between the two groups,and the effective rate of the treatment group was obviously higher than that of the control group(P<0.05). ⑤After treatment,there was statistically significant difference on ZPS score between the two groups,and the ZPS score of the treatment group was obviously lower than that of the control group(P<0.05). ⑥After treatment,there were statistically significant differences on the levels of CD3+,CD4+ and CD4+/ CD8+ between the two groups,and the improvement in the treatment group was significantly better than that in the control group(P<0.05). Conclusion:Acupuncture combined with auricular therapy and three-step analgesic ladder can be used in the treatment of cancer pain,which can significantly alleviate the cancer pain and improve the quality of life and cellular immune function of patients. It also can reduce the analgesics usage and side reactions caused by analgesics to some extent.关键词：cancer pain;acupuncture analgesia;auricular therapy;analgesics;side reactions;quality of life;immune function
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发布时间：2022-08-31 - 摘要：Objective:To study the postoperative clinical efficacy of endoscopic resection combined with Shugan Hewei Decoction in the treatment of gastric polyps. Methods80 patients with gastric polyps were randomly divided into the treatment group and control group,40 cases in group. Both groups were treated with endoscopic resection and proton pump inhibitor. In addition,the treatment group was treated with Shugan Hewei Decoction by oral administration. The drug treatment course was one month in both groups. The clinical efficacy,TCM syndrome scores and serum levels of pepsinogen(PG)were observed in both groups. Results:①The clinical efficacy of the treatment group was significantly better than that of the control group(P<0.01). ②After treatment,the TCM syndrome scores were significantly decreased in both groups compared with treatment before(P<0.05),and the scores of the treatment group were lower than those of the control group(P<0.05).③After treatment,the serum level of PGⅠand the ratio of PGⅠand PGⅡ(PGR)were significantly increased in both groups compared with treatment before(P<0.05),and the levels of the treatment group were significantly higher than those of the control group(P<0.05). Conclusion:Endoscopic resection combined with Shugan Hewei Decoction in the treatment of gastric polyps can significantly improve the clinical symptoms and promote the repair of gastric mucosal.关键词：gastric polyps;endoscopic mucosal resection;endoscopic argon plasma coagulation;Shugan Hewei Decoction
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发布时间：2022-08-31 - 摘要：Objective:To observe the clinical efficacy of acupuncture on Tiantu acupoint(CV22) combined with omeprazole in the treatment of laryngopharyngeal reflux disease. Methods202 patients of laryngopharyngeal reflux disease were randomly divided into the treatment group(102 cases)and control group(100 cases).The control group was orally treated with omeprazole enteric-coated capsule,and the treatment group was treated with acupuncture on Tiantu acupoint based on the treatment for the control group,with a course of 2 months. The clinical efficacy was observed,and the changes on the single item score and total score in reflux symptom index (RSI) scale and reflux finding score (RFS) scale were compared. Results:①The clinical total effective rates were 78.43% in the treatment group and 63.00% in the control group. The clinical efficacy of the treatment group was significantly better than that of the control group(P<0.05). ②After treatment,there were statistically significant differences on the RSI total score and single item score of persistent throat clearing,cough after meals or lying down,disturbing cough and foreign body sensation in throat between the two groups,and the improvement on the symptoms in the treatment group was obviously better than that in the control group(P<0.05). After treatment,there were statistically significant differences on the RFS total score and single item score of erythema/hyperemia,edema in vocal cords,diffuse laryngeal edema and posterior commissure hyperplasia between the two groups,and the improvement on the signs in the treatment group was obviously better than that in the control group(P<0.05). Conclusion:Acupuncture on Tiantu acupoint combined with omeprazole by oral administration shows good efficacy in the treatment of laryngopharyngeal reflux disease.关键词：laryngopharyngeal reflux disease;Tiantu acupoint(CV22);acupuncture;upper esophageal sphincter;pneumogastric nerve
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发布时间：2022-08-31 - 摘要：Objective:To observe the clinical efficacy of wrist-ankle acupuncture combined with fumigation and steaming therapy of Chinese medicine in the treatment of diabetic peripheral neuropathy with syndrome of blood stasis in channels and collaterals. MethodsBased on the random and controlled trial,64 patients were divided into the treatment group and control group,32 cases in each group. The treatment group was treated with wrist-ankle acupuncture combined with fumigation and steaming therapy of Chinese medicine and the control group was treated with mecobalamin by intramuscular injection,with a course of 3 months. The clinical efficacy was observed,and the changes on clinical symptom score,hemorheological indexes and neuropathy scores were compared before and after treatment. Results:①The total effective rates were 87.5% in the treatment group and 59.4% in the control group,and the clinical efficacy of the treatment group was significantly better than that of the control group,with statistical difference(P<0.05). ②After treatment,the clinical symptom score and neuropathy scores were obviously decreased in both groups(P<0.05),and the scores of the treatment group were lower than those of the control group(P<0.05). ③After treatment,the levels of whole blood high and low shear viscosity,plasma viscosity and fibrinogen were significantly decreased in both groups(P<0.05),and the levels of the treatment group were lower than those of the control group(P<0.05). Conclusion:Both intramuscular injection of mecobalamin and wrist-ankle acupuncture combined with fumigation and steaming therapy of Chinese medicine could improve the symptoms of diabetic peripheral neuropathy with syndrome of blood stasis in channels and collaterals. The efficacy of wrist-ankle acupuncture combined with fumigation and steaming therapy of Chinese medicine is better than that of intramuscular injection of mecobalamin.关键词：diabetes;peripheral neuropathy;wrist-ankle acupuncture;fumigation and steaming of Chinese medicine
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发布时间：2022-08-31 - 摘要：Objective:To compare the clinical efficacy of warm needling,electroacupuncture and quick cupping in the treatment of peripheral facial paralysis at acute stage. Methods112 patients with peripheral facial paralysis at acute stage were randomly divided into the control group,warm needling group,electroacupuncture group and quick cupping group,28 cases in each group. The control group was treated with single therapy of western medicine,the warm needling group was treated with facial warming acupuncture on affected side,the electroacupuncture group was treated with electroacupuncture therapy,and the quick cupping group was treated with quick cupping stimulation after acupuncture,with a course of 4 weeks. The clinical efficacy,House-Brackmann(H-B)facial nerve grading scale and healing time in each group were compared. Results:①The total effective rates were 96.4% in the warm needling group,85.7% in the electroacupuncture group,85.7% in the quick cupping group and 75.0% in the control group. The total effective rate of the control group was lower than that of the other groups(P<0.05).The efficacy of the warm needling group was better than that of the electroacupuncture group and quick cupping group(P<0.05). ②Compared with treatment before,the H-B facial nerve grading were obviously improved in all the groups after treatment(P<0.01).After treatment,the H-B facial nerve grading in the three groups that treated with acupuncture-moxibustion therapies were better than those in the control group(P<0.01),and the H-B facial nerve grading in the warm needling group were better than those in the electroacupuncture group and quick cupping group(P<0.05). ③The healing time in the three groups that treated with acupuncture-moxibustion therapies was all less than that in the control group(P<0.05),and the healing time in the warm needling group was less than that in the electroacupuncture group and quick cupping group(P<0.05). Conclusion:Acupuncture-moxibustion therapies show significant efficacy in the treatment of peripheral facial paralysis at acute stage. Among,the therapy of warm needling shows obvious advantages in recovering facial nerve function and healing time.关键词：peripheral facial paralysis;acute stage;acupuncture-moxibustion therapy;therapy of warm needling;therapy of electroacupuncture;therapy of quick cupping
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发布时间：2022-08-31 - 摘要：Objective:To observe the clinical efficacy of acupuncture combined with foot reflex region bloodletting in the treatment of primary trigeminal neuralgia. MethodsSixty patients of primary trigeminal neuralgia were randomly divided into the treatment group and control group,30 cases in each group. The treatment group was treated with acupuncture combined with bloodletting therapy in foot reflex region,and the control group was orally treated with carbamazepine. The treatment course in both groups was 30 days with follow-up for 3 months. The clinical efficacy and recurrence rate were observed,and the change on visual analogue scale(VAS)score was compared. Results:①The clinical total effective rates were 80.00% in the treatment group and 73.33% in the control group. The clinical efficacy of the treatment group was obviously better than that of the control group(P<0.05). ②After treatment,there was statistically significant difference on VAS score between the two groups,and the VAS score of the treatment group was obviously lower than that of the control group(P<0.05). ③There was statistically significant difference on the recurrence rate between the two groups,and the recurrence rate of the treatment group was obviously lower than that of the control group(P<0.05). Conclusion:Acupuncture combined with foot reflex region bloodletting shows better efficacy in the treatment of primary trigeminal neuralgia,which can significantly alleviate the facial pain of patients with lower recurrence rate.关键词：primary trigeminal neuralgia;acupuncture;bloodletting therapy;biological holographic reflection region;non-drug therapy
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发布时间：2022-08-31 - 摘要：Objective:To observe the clinical efficacy of recipes with effects of tonifying kidney and promoting blood circulation combined with low molecular weight heparin in the treatment of recurrent spontaneous abortion(RSA)caused by prethrombotic state. Methods90 RSA patients caused by prethrombotic state were randomly divided into the treatment group and control group,45 cases in each group. Based on the luteal support therapy,the treatment group was treated with recipes with effects of tonifying kidney and promoting blood circulation combined with low molecular weight heparin,and the control group was treated with low molecular weight heparin,with a course of 30 days. The embryo survival rate at pregnancy of 12 weeks,the levels of coagulation related indicators including fibrinogen(FIB)and D-Dimer were observed and compared. Results:①The embryo survival rates at pregnancy of 12 weeks were 86.67％ in the treatment group and 71.11％ in the control group. There was statistically significant difference on the embryo survival rate at pregnancy of 12 weeks between the two groups,and the survival rate of the treatment group was obviously higher than that of the control group(P<0.05). ②For the comparison between treatment before and after within group,there were statistically significant differences on the levels of FIB and D-Dimer in both groups(P<0.05).After treatment,there were statistically significant differences on the levels of FIB and D-Dimer between the two groups,and the levels of the treatment group were obviously lower than those of the control group(P<0.05). Conclusion:Recipes with effects of tonifying kidney and promoting blood circulation combined with low molecular weight heparin show good efficacy in the treatment of recurrent spontaneous abortion caused by prethrombotic state,which can significantly improve the prethrombotic state and increase the success rate of tocolysis.关键词：recurrent spontaneous abortion;early stage;prethrombotic state;Danshen Injection;Shoutai Pill;syndrome of kidney deficiency blood stasis;tocolysis
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发布时间：2022-08-31 - 摘要：Objective:To observe the efficacy of therapy of benefiting qi and nourishing yin and clearing heat in the treatment of postoperative wound swelling and pain of high anal fistula with syndrome of dampness-heat diffused downward. Methods78 patients of high anal fistula with syndrome of dampness-heat diffused downward who had received the operation were randomly divided into the observation group and control group,39 cases in each group. The observation group was treated with therapy of benefiting qi and nourishing yin and clearing heat,and the control group was treated with therapy of clearing heat and eliminating dampness,with a course of 4 weeks. The changes on the syndrome efficacy and scores of wound swelling and pain in patients were observed. Results:①The syndrome efficacy of the observation group was better than that of the control group(P<0.05),especially the improvement on yellow greasy fur(P<0.01).②The scores of wound pain,exudation and edema in the observation group were all lower than those in the control group(P<0.05,P<0.01). Conclusion:Compared with the single therapy of clearing heat and eliminating dampness,the therapy of benefiting qi and nourishing yin and clearing heat can more effectively alleviate the postoperative clinical symptoms and wound swelling and pain of high anal fistula with syndrome of dampness-heat diffused downward.关键词：high anal fistula;syndrome of dampness-heat diffused downward;therapy of benefiting qi and nourishing yin and clearing heat;therapy of clearing heat and eliminating dampness;postoperative wound
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发布时间：2022-08-31 - 摘要：There were 18 formulas that involved the combination of Radix Astragali seu Hedysari and Rhizoma Anemarrhenae in Records of Integrated Chinese and Western Medicine(Yixue Zhongzhong Canxi Lu)written by Zhang Xichun,which could treat seven kinds of internal medicine diseases. Radix Astragali seu Hedysari and Rhizoma Anemarrhenae,show the opposite drug nature and flavours. The former can tonify qi with effects of ascending and dispersing,while the latter can nourish yin with effects of descending and astringing. In Zhang’s 18 formulas that involved the combination of two drugs,when they were used in equivalent amount,it reflected the compatibility characteristics such as simultaneous supplementation of qi and blood,combination of tonifying and clearing methods for calming endogenous and exogenous wind,co-regulation of cold and warm for mutual restriction. When Radix Astragali seu Hedysari was more used with less Rhizoma Anemarrhenae,it mainly reflected the compatibility characteristics such as culturing primordial qi and ascending the sinking qi,preventing vanishing and relieving desertion,ascending the sinking qi and smoothing the secretion,making qi transformation orderly,combined application of drugs with sweet and bitter flavours,combination of tonifying and resolving methods. When Rhizoma Anemarrhenae was more used with less Radix Astragali seu Hedysari,it could simultaneously regulate the lung and spleen and nourish yin for astringing. Through the compatibility characteristics of 18 formulas,the unique opinions of Zhang’s academic thoughts and medication in syndrome differentiation and treatment were further understood.关键词：Zhang Xichun;Radix Astragali seu Hedysari;Rhizoma Anemarrhenae;compatibility
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发布时间：2022-08-31 - 摘要：Objective:To study the effects of Ruyiping medicated serum on proliferation and invasion of mouse mammary carcinoma 4T1 cells,and discuss its mechanism. Methods①The medicated serum of Ruyiping with different concentrations(10%,20%,30% and 40%) were prepared,and the blank serum at same concentrations were taken as the control. The effect of medicated serum on the viability of 4T1 cells was detected by methylthiazolyldiphenyl-tetrazolium(MTT)assay to screen the optimum concentration and exposure time. ②The cells were divided into the blank control group,TGF-β1 control group,Ruyiping medicated serum groups with low(10%)- and high(20%)-concentration. Except the blank control group,the cells in the other groups were all given the pre-treatment with TGF-β1 at concentration of 2 mg/L for 3 hours. And then the cells were treated with blank serum or medicated serum for 48 hours respectively. The effect of medicated serum on the invasion of TGF-β1 pre-treated 4T1 cells was detected Transwell test. The effects of medicated serum on the expressions of Smad4 and Smad7 in TGF-β1 pre-treated 4T1 cells were determined by Western blotting and Real-time PCR. Results:①The Ruyiping medicated serum significantly inhibited the proliferation activity of 4T1 cells. 10% and 20% were taken as the optimum concentrations,and 48 hours was taken as the optimum exposure time for the experiment. ②The Ruyiping medicated serum significantly inhibited TGF-β1-induced high invasion of 4T1 cells,with a concentration-dependent manner. The results of Western blotting and Real-time PCR showed that,the Ruyiping medicated serum obviously reversed the high mRNA and protein expressions of Smad4 induced by TGF-β1,but no effects on the up-regulated mRNA and protein expressions of Smad7 were observed. Conclusion:Ruyiping medicated serum could inhibit the proliferation and invasion of 4T1 cells. Its mechanism may be associated with the regulation on the expressions of related factors in TGF-β/Smads signal pathway.关键词：Ruyiping;medicated serum;4T1 cells;TGF-β/Smads signal pathway
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发布时间：2022-08-31 - 摘要：Objective:To study the influence of Jianpi Jiedu Recipe on the expression of vascular endothelial growth factor (VEGF),angiopoietin-2(Ang-2) and basic fibroblast growth factor(bFGF) in Helicobacter pylori(HP)-infected gastric cancer cells,and discuss its possible mechanism. MethodsHuman gastric cancer MKN45 cells were infected by HP standard strain NCTC11637 by co-culture. The cells were divided into the control group,HP infection group,alcohol extract of Jianpi Jiedu Recipe(JPJD)groups with low-,medium- and high-dose(as 0.5 g/L,1.0 g/L and 2.5 g/L respectively).The effects of Jianpi Jiedu Recipe on the expression of VEGF,bFGF and Ang-2 in HP infected MKN45 cells were detected by ELISA. After the inhibition on Wnt/β-catenin activity by the specific inhibitor FH-535 at concentration of 20 μmol/L,the cells were infected by HP once again,and the expression changes of VEGF,bFGF and Ang-2 in MKN45 cells were detected by ELISA. The regulation of Jianpi Jiedu Recipe on the activity of Wnt/β-catenin signaling pathway in HP infected MKN45 cells were determined by Western blotting. Results:After 12 hours of HP infection,the expression of VEGF,bFGF and Ang-2 in MKN45 cells were obviously up-regulated(P<0.01). The JPJD alcohol extract with low-,medium- and high-dose could all down-regulate the expressions of VEGF,bFGF and Ang-2 in HP infected MKN45 cells,with a certain dose-dependent manner. After the intervention of FH-535,the activity of Wnt/β-catenin was suppressed,the expressions of VEGF,bFGF and Ang-2 were obviously inhibited in HP infected MKN45 cells (P<0.01). After 12 hours of HP infection,the protein expression of β-catenin in cytoplasm and nucleus of MKN45 cells was obviously up-regulated(P<0.01). Jianpi Jiedu Recipe could down-regulate the protein expression of β-catenin in cytoplasm and nucleus,with a certain dose-dependent manner. Conclusion:Jianpi Jiedu Recipe could down-regulate the expressions of VEGF,bFGF and Ang-2 in HP-infected human gastric cancer cells,and the inhibition on Wnt/β-catenin signaling pathway is one of its mechanisms,which may be its important mechanism in the treatment of gastric cancer.关键词：Helicobacter pylori;JianPi JieDu Recipe;gastric cancer;Wnt/β-catenin;angiogenesis
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发布时间：2022-08-31 - 摘要：Objective:To investigate the influence and mechanism of bufalin-loaded Pluronic- polyetherimide(PEI)nanoparticles on the growth of colorectal cancer Lovo cells in vitro and vivo via miR-497 mediated IGF1-R-PI3K-Akt signaling pathway. MethodsThe colorectal adenocarcinoma Lovo cells were transfected by lentivirus miR-497. The effects of bufalin-loaded Pluronic-PEI nanoparticles on proliferation,invasion and metastasis of Lovo cells in vitro were observed,as well as the regulation on the related gene and protein in miR-497 mediated IGF1-R-PI3K-Akt signaling pathway. The orthotopic xenograft model of colorectal cancer was established in nude mice. The mice were sacrificed after 8 weeks,and the tumor formation was observed. Results:①Compared with the control group,the proliferation inhibition rate of bufalin-loaded Pluronic-PEI nanoparticles on miR-497 overexpressed Lovo cells was the most significant and was increased in a time and dose dependent manner,and the apoptosis rate of miR-497 overexpressed Lovo cells was increased from (28.93±0.24)% to (75.20±0.29)%,which was significantly higher than that of the Lovo cells and Lovo NC cells treated with the same concentration(P<0.01). In the scratch assay,the migration rate of miR-497 overexpressed Lovo cells was decreased from (0.083±0.019)(25 nmol/L)to (-0.242±0.035)(400 nmol/L)in a dose-dependent manner. ②The Transwell assay showed that bufalin-loaded Pluronic-PEI nanoparticles at concentration of 25 nmol/L could significantly inhibit the invasion of miR-497 overexpressed Lovo cells. ③Western blot showed that the protein expressions of p-Akt Ser473 and p-Akt Thr308 in Lovo NC cells and miR-497 overexpressed Lovo cells were significantly decreased after the treatment with bufalin-loaded Pluronic-PEI nanoparticles and LY294002,but there was no obvious change on the expression of pan-Akt. ④In vivo experiments,the effects of bufalin-loaded Pluronic-PEI nanoparticles on inhibiting tumor metastasis were better than those of bufalin. Conclusion:Bufalin-loaded Pluronic-PEI nanoparticles can inhibit the invasion and metastasis of colorectal cancer in vitro and vivo via miR-497 mediated IGF1-R-PI3K-Akt signaling pathway.关键词：bufalin;nanoparticles;miR-497;IGF1-R-PI3K-Akt;colorectal cancer
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发布时间：2022-08-31 - 摘要：Objective:To discuss the postponed effects of whole- and intermittent-way massage manipulation combined with treadmill training on denervated skeletal muscle atrophy. Methods40 SD rats were randomly divided into the normal control group,denervation group,whole-way massage group and intermittent-way massage group,10 rats in each group. Except the normal control group,the denervation model of sciatic nerve was established in the other groups. After modeling, no treatments were performed for 3 weeks. The whole-way massage group was treated with pinching manipulation and treadmill training once a day for 2 months,and the intermittent-way massage group was treated with pinching manipulation and treadmill training once a day for one month and then rested for one month. After intervention,the gastrocnemius wet weight ratio was detected,and the positive areas of cytokines including insulin-like growth factor-I(IGF-I),basic fibroblast growth factor(bFGF)and myogenic differentiation factor(MyoD)were determined. Results:Compared with the whole-way massage group,the levels of cytokines were obviously increased in the intermittent-way massage group(P<0.05),and the gastrocnemius wet weight ratio was obviously decreased(P<0.05). Conclusion:The whole-way massage manipulation combined with treadmill training can delay the denervated skeletal muscle atrophy in a certain extent.关键词：massage;treadmill training;skeletal muscle atrophy;cytokines;rats
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发布时间：2022-08-31 - 摘要：Objective:To establish an HPLC method for content determination of vaccinoside in leaves of Vaccinium bracteatum Thunb.. MethodsBy tracking the dyeing activity,the active ingredients were isolated and identified. The content determination was performed by HPLC with a Cosmosil-5C18-PAQ column (4.6 mm×250 mm,5 μm). The mobile phase was 0.3% acetic acid- acetonitrile with gradient elution at a flow rate of 1.0 ml/min. The wavelength of detection was 320 nm. Results:Vaccinoside was separated and identified as the main active ingredient. The chromatographic analysis showed a good separation. There was a good linearity in the range of 0.052 08-0.520 8 g/L(r=0.999 8). The recovery rate was 98.61%. Conclusion:The determination method is quick and accurate,which could provide reference for the quality control of vaccinoside in leaves of Vaccinium bracteatum Thunb..关键词：Vaccinium bracteatum Thunb.;vaccinoside;HPLC;quality control
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发布时间：2022-08-31 - 摘要：This paper reviews the research progress on pharmacological effects and mechanism of Herba Pogostemonis. As a clinical commonly used aromatic with effects of resolving dampness,it mainly includes volatile components such as patchouli alcohol and pogostone and non-volatile components such as flavonoids. It shows various pharmacological effects such as protecting the gastrointestinal tract,anti-pathogenic microorganism,anti-inflammatory,analgesic activity,relieving fever,antiemetic action,arresting cough,dissipating phlegm,relaxing bowels,anti-oxidation,anti-tumor,regulation of immune system and so on.关键词：Herba Pogostemonis;pharmacological effects;mechanism;research progress
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发布时间：2022-08-31 - 摘要：The physiological and pathological organs and tissues in human body can be observed by magnetic resonance imaging(MRI),which regarded as a fundamental complement for traditional cognition methods of human body by governing exterior to infer interior in traditional Chinese medicine(TCM).In recent years,the research of syndrome differentiation and classification based on MRI have found that,diseases such as lumbar disc herniation,knee osteoarthritis,cervical spondylosis,osteonecrosis of femeral head,breast cancer,mastitis and stroke,there are differences on the local morphological structure changes among various patterns,especially,there are significant differences between syndrome of excess and deficiency. Combined with MRI application,the morphological structure changes in body caused by compound of Chinese medicine could be observed more intuitively,acupuncture on dangerous acupoints could be tested in vivo owing to the avoidance of important organs injury. The application of functional magnetic resonance imaging (fMRI) has found that acupuncture on acupoints in different meridians could show superposed activation on the same brain region. fMRI is possible to more widely observe the functional changes of various tissue structures,which may be the research direction of TCM syndrome differentiation and efficacy judgement in the future.关键词：magnetic resonance imaging;traditional Chinese medicine;syndrome differentiation;acupuncture
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发布时间：2022-08-31
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