最新刊期
期 7 ， 2016
- 摘要：This article introduced the clinical experience of Professor Peng Peichu in the treatment of advanced prostate cancer. Professor Peng proposed “lung-kidney insufficiency” in hormone dependent stage and “yin deficiency affecting yang” in hormone independent stage as the main pathogenesis,and advocatd the treatment idea of “mutual promotion between lung and kidney and and reinforcing the mother-organ to treat deficiency” for hormone dependent stage and “warming kidney yang and regulating the sanjiao” for hormone independent stage responsively. The corresponding basic prescription for addition and subtraction was summarized. Two proven case was presented for example.
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发布时间：2022-08-31 - 摘要：There are various items of the etiology and pathogenesis of insomnia in TCM theory,in which over-thinking,depression,sadness,anger,panic and so on are considered as the key emotional factors to the occurrence of insomnia. As a main and common symptom of depression syndrome,dysfunctions of heart,spleen,liver and gallbladder play important role in the pathogenesis of insomnia.This paper divided the classifications of emotions into “the external emotional factors” and “the internal emotional factors”.The former refers to irritable emotional changes caused by negative events. When inner peace is retrieved,insomnia is almost cured. The latter refers to psychological characteristics of depression syndrome,personality traits and Qi-stagnation constitution of the individual.The one who has “the internal emotional factors” always shows susceptibility and irritability to those external emotional stimulations,and can behaves depression,sadness,anger,panic and refractory insomnia. In most cases,good night sleep relieves depression,while the disappearance of depression syndrome promotes better sleep. So in the treatment of insomnia due to depression syndrome,soothing the liver and relieving depression could tranquilize mind and promot sleep,and vice versa. Relieving depression and promoting sleep interact on each other.关键词：depression syndrome;insomnia;classifications of emotions;relieving depression and promoting sleep
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发布时间：2022-08-31 - 摘要：This paper analyzed the limitation of modern anatomy in recognition of human physiology and pathology, and discussed non-anatomic knowledge and practice of human life movement based on Chinese medicine,and investigated the value and significance of non anatomical structure of meridian combined with modern research results of meridian structure. It is considered that the development of non anatomic structure should be led by multiple think, from anatomy to non anatomy, and then explore the new field of recognition for human structure.关键词：meridian;morphology;non anatomical structure
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发布时间：2022-08-31 - 关键词：community-acquired pneumonia;therapy of integrated traditional Chinese and western Medicine;clinical guidelines
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发布时间：2022-08-31 - 摘要：This paper introduces Professor Zhao Heping’s clinical experience in the treatment of childhood asthmatic bronchitis. It is believed that the disease is caused primarily by healthy qi deficiency and phlegm accumulation; that its treatment differs by stages and lies in regulating the spleen and stomach, herbal ointment, internal and external modalities. A proven case is presented for example.关键词：childhood asthmatic bronchitis;clinical experience;Zhao Heping
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发布时间：2022-08-31 - 摘要：This paper introduced Professor Shen Xiaoheng’s experience on medication treatment of chronic gastritis.Professor Shen emphasized the combination of Chinese and Western medicine clinical diagnosis as well as disease and syndrome differentiation.The methods included qi regulation, relaxation, gallbladder and stomach treatment together, spleen and kidney co-tonifying and so on,which commonly used herbs consist of Atractylodes, Phoenix clothing, hedgedog skin, Wang Jiangnan etc.关键词：chronic gastritis;clinical experience;Shen Xiaoheng
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发布时间：2022-08-31 - 摘要：This paper introduced Professor Jiang Zhiyan’s clinical experience in the treatment of Mycoplasma pneumoniae in children by collateral-unblocking therapy. Professor Jiang advocated that the mild cases in acute stage were treated by lung-clearing and collateral-unblocking therapy, the severe cases in acute stage were treated by phlegm-removing and collateral-unblocking therapy, and the cases in the recovery stage were treated by deficiency-tonifying and collateral-unblocking therapy. One proven case was presented for example.关键词：collateral-unblocking therapy;Mycoplasma pneumoniae;clinical experience;Jiang Zhiyan
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发布时间：2022-08-31 - 摘要：The paper introduced the clinical experience of Professor Chen Jianjie in the treatment of liver cirrhosis with high alpha fetal protein. In the pathogenesis, Professor Chen proposed most liver cirrhosis patients with high alpha fetal protein were with the syndrome of damp-heat combined with toxin stasis, blood stasis blocking collaterals,liver stagnation and spleen deficiency. In the treatment the methods of invigorating spleen and eliminating dampness, clearing heat and toxin and resolving hard lump were advocated. Ershu Jiedu Decoction was formulated and good clinical efficacy was achieved. One proven case was provided.关键词：liver cirrhosis;alpha fetal protein;clinical experience;Chen Jianjie
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发布时间：2022-08-31 - 摘要：This paper elaborates the connotation “consumptive condition, vexation and sleeplessness” in the indications of “Suanzaoren Decoction”, and introduces its application in clinical practice and relative action mechanisms. It is argued that this Decoction is indicated for “liver-blood deficiency and deficiency-heat disturbance” in pathogenesis, with the symptoms of insomnia, fatigue worsened by working and restless following work.关键词：“Suanzaoren Decoction”;enriching blood, regulating liver and calming spirit;clinical application;pharmacological mechanism
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发布时间：2022-08-31 - 摘要：This paper reviewed the analysis of relationship between heat invading blood chamber and gynecological disease in Treatise on Febrile Diseases. Through analysis of the definition, recognition of heat invading the blood chamber in modern medicine was introduced, the relationship between different gynecological diseases and heat invading the blood chamber were analyzed. The methods of treating heat invading the blood chamber in the different phases of the menstrual period were summarized.关键词：Treatise on Febrile Diseases;syndrome of heat invading blood chamber;treatment based on syndrome differentiation
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发布时间：2022-08-31 - 摘要：This article presents Zou Shu’s experience with the differentiation and treatment of vexation. It is held that vexation lies in the heart; that simple vexation is not a critical condition and vexation with restlessness signifies critical condition; that eight treatment methods and four essential herbs(Fructus Gardeniae, Semen Sojae Preparatum, Semen Ziziphi Spinosae and Fructus Mume) are introduced to clarify the herbal prescription for vexation.关键词：vexation;Benjingxu Shuyao;experience in herbal prescription;Zou Shu;Zhang Zhongjing
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发布时间：2022-08-31 - 摘要：Objective:To observe the effects of Chuankezhi injection on the treatment of COPD patients in GOLD II-III stable period via different administration. Methods 90 cases of COPD patients in stable stage of grade 2-3 according to GOLD ranks were randomly divided into 3 groups, treatment group A, treatment group B and control group, 30 cases in each group . Patients in control group were treated with thiazide tiotropium powder for inhalation therapy, treatment group A was treated with Chuankezhi injection for muscle injection at gluteus maximus,and treatment group B was treated with Chuankezhi injection for acupoint injection at Zusanli. The course of treatment was 6 months. The changes of CAT score for syndrome, walking distance within 6 min(6MWD), lung function (FEV1, FEV1/FVC, FEV1%) and TCM syndrome score were observed and compared. Results:①Compared with the control group, the differences of CAT score and level of 6MWD in the treatment group A and B were statistical significant (P<0.05).Compared with the treatment group A,the CAT score in treatment group B decreased significantly and the level of 6MWD improved more obviously(P<0.05). ②Compared with the control group, the differences of level of FEV1,FEV1/FVC,FEV1% in the treatment group A and B were statistical significant (P<0.05).Compared with the treatment group A, the level of these indicators in treatment group B increased significantly(P<0.05). ③Compared with the control group, the differences of TCM syndrome score in the treatment group A and B were statistical significant (P<0.05). Compared with the treatment group A, the TCM syndrome score in treatment group B decreased significantly(P<0.05). Conclusion:Chuankezhi injection combined with thiazide tiotropium powder inhalant could be used for the treatment of COPD patients in GOLD II-III stable period,and acupoint injection showed better efficacy than intramuscular injection.
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发布时间：2022-08-31 - 摘要：Objective:To observe the clinical efficacy of Xiao Cheng-Qi decoction combined conventional western medecine in the treatment of pulmonary infections on patients with postoperative severe craniocerebral injury. Methods 67 cases of pulmonary infections on patients with postoperative severe craniocerebral injury were randomly divided into treatment group(34 cases) and control group(33 cases). Conventional western medecine treatment was given to both groups,and additionally,Xiao Cheng-Qi decoction was applied to treatment group, with a course of one week. The clinical efficacy was observed and changes of the levels of correlated biochemical indexes including WBC、CRP、PCT and clinical pulmonary infection score(CPIS)between two groups were compared. Results: ①The effective rate of the treatment group is 93.3%,and the control group is 70.0%,the difference between two groups was statistically significant (P<0.05). ②After three-day treatment,the levels of PCT obviously decreased in the treatment group than the control group(P<0.05). After seven-day treatment,the levels of WBC、CRP、PCT and CPIS significantly decreased in the treatment group than the control group(P<0.05). Conclusion:Xiao Cheng-Qi decoction combined conventional western medecine could be used to treat pulmonary infections on patients with postoperative severe craniocerebral injury, which significantly relieve pulmonary infections and inflammatory response in patients.关键词：postoperative severe craniocerebral injury;pulmonary infections;Xiao Cheng-Qi decoction;phlegm- heat obstructing lungs;purgative method;test of classical prescription
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发布时间：2022-08-31 - 摘要：Objective:To observe the clinical efficacy and safety of Yi Zhi Ping Chan Granule on Parkinson’s disease combined with mild cognitive impairment. Methods:Eighty patients with PD-MCI were randomly divided into treatment group and control groups.Each group had forty patients. Both groups were treated with routine western medicine, and the treatment group were given Yi Zhi Ping Chan granule additionally,with a course of 3 month. The score changes of UPDRSⅡ、Ⅲ、 ADL、MMSE、 MOCA、PANDA before and after treatment were observed,as well as the adverse reactions by TESS. Results:① Compared within each group after treatment,the score of ADL decreased significantly in the treatment group(P<0.05),the score of UPDRSⅡ,UPDRSⅢ increased significantly in the control group(P<0.05)；compared with the control group after treatment,the score of ADL,UPDRSⅡ and UPDRSⅢ decreased significantly in the treatment group(P<0.05). ② Compared within each group after treatment,the score of MMSE,MoCA and PANDA increased significantly in the treatment group(P<0.05),the score of MoCA decreased significantly in the control group(P<0.05)；compared with the control group after treatment,these scores increased significantly in the treatment group(P<0.05). The incidence rate of adverse reaction in the treatment group (7.5%) was significantly lower than that in the control group (50%). The score of TESS decreased significantly in the treatment group compared with control group(P<0.05). Conclusion:Yi Zhi Ping Chan granule can significantly and safely improve cognition level of PD-MCI patients,as well as the clinical symptoms and activities of daily living.关键词：Parkinson’s disease;mild cognitive impairment;therapy integrated traditional chinese and western medicine;Yi Zhi Ping Chan granule
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发布时间：2022-08-31 - 摘要：Objective:To observe the clinical effects of Qin’s Eight Acupoints with syndrome-differentiated acupoints in the treatment of up-rising phlegm-turbidity chronic daily headache. MethodsSixty-three subjects were randomized into observation group(n=32) and control group(n=31), and were treated by Qin’s Eight Acupoints; meanwhile, the observation group was treated by acupoints Zusanli(ST 36), Sanyinjiao(SP 6) and Fenglong(ST 40), and the control group was treated by sham acupoints lateral to above ones, with a course of 8 weeks.The headache dairy including attack frequency, visual analogue scale(VAS), lasting duration, syndrome score, migraine disability assessment(MIDAS) and SF-36 scale were assessed before and after treatment. Results:①After treatment, the headache attack frequency, visual analogue scale(VAS) and lasting duration were obviously reduced in both groups(P<0.05,P<0.01), with lower VAS score in the observation group than in the control group(P<0.05). ②After treatment, the syndrome scores were strikingly decreased in both groups(P<0.01), with no significance between the two groups(P>0.05). ③After treatment, the MIDAS scores were obviously reduced in both groups(P<0.01), with no significance between the two groups(P>0.05). ④After treatment, the PCS and MCS scores were increased in both groups(P<0.01), with more significant increase in the observation group than in the control group(P<0.01). Conclusion:Qin’s Eight Acupoints with syndrome-differentiated acupoints is effective to help chronic daily headache and improve the quality of life.关键词：chronic daily headache;Qin’s Eight Acupoints;acupoint selection on syndrome differentiation;Qin Liangfu
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发布时间：2022-08-31 - 摘要：Objective:To observe the protective effiects of modified Qingying decoction on gastrointestinal functionon in elderly patients with sepsis. Methods 62 patients were randomly divided into treatment group and control group, 31 in each group. Two groups were both treated with routine western medicine. Additionally treatment group was given modified Qingying decoction orally. Course of treatment for both groups was 7 days. The change of score of acute physiology and chronic health situation (APACHE II),the level of heme oxygenase-1(HO-1)and procalcitonin (PCT),the intra-abdominal pressure(IAP), the gastrointestinal decompression amount, the pH of gastrointestinal mucosa(pHi) were observed. The opening time of gastrointestinal tract, the incidence of MODS and mortality within follow-up 28 days were recorded. Results: ①Compared with the control group after treatment, the APACHE II score and the level of HO-1 and PCT in treatment group decreased more significantly(P<0.05). ②Compared with the control group after treatment, the IAP, the gastrointestinal decompression amount and the pHi in treatment group decreased more significantly(P<0.05). ③The difference of the opening time of gastrointestinal tract, the incidence of MODS,and mortality within follow-up 28 days between two groups was statistically significant. The prognosis of the treatment group was significantly better than that of the control group. Conclusion: The modified Qingying decoction combined with conventional western medicine therapy could be used for elderly patients with sepsis,which suppress the inflammatory reaction and start the body gastrointestinal protection system so as to shorten the opening time of the gastrointestinal tract and reduce the incidence of MODS.关键词：sepsis;elderly patients;gastrointestinal function;Qingying decoction;Rhubarb;Magnolia;epidemic febrile disease
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发布时间：2022-08-31 - 摘要：Objective:To observe the clinical effects of “Qiqing Xiaodian Decoction” on allergic purpura and the level of immunoglobulin and complement. Method 60 patients with allergic purpura were randomly divided into treatment group and control group,30 patients in each group. Patients in treatment group were treated with Qi-qing-xiao-dian decoction, while patients in control group were treated with conventional western medicine(antihistamines and glucocorticoid),with a course of 8 weeks. The clinical efficacy and the change of indicators related to immunity such as immunoglobulin (IgA, IgE, IgM, IgG) and complement (c3, c4) were observed. Results: ①The total effective rate were 96.7% in the treatment group and 93.3% in the control group respectively. There was no statistical significance between groups (P>0.05). ②The level of IgA,IgE,IgG and IgM within each group before and after treatment significantly decreased (P<0.05)；after treatment, the differences of the level of these indicators between two group were statistical significant(P<0.05). ③Compared within each group before and after treatment, the level of c3 increased significantly in both groups(P<0.05), while the difference of the level of c4 was not statistical significant (P>0.05). After treatment, there were no statistical significance between groups on the level of c3 and c4 (P>0.05). Conclusion:①When allergic purpura attacks acutely, the level of immunoglobulin (IgA, IgE, IgM, IgG) increase and the level of complement c3 decrease. ②“Qiqing Xiaodian Decoction” showed good clinical effects on allergic purpura with the therapy of supplement Qi and dispeling wind. The mechanism was related to regulating humoral immunity, enhancing the nonspecific immune reaction of the body, alleviating the allergic reaction of vessels and capillary fragility.关键词：allergic purpura;therapy of supplement Qi with dispeling wind;“Qiqing Xiaodian Decoction”;immunoglobulin;complement
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发布时间：2022-08-31 - 摘要：Objective:To observe the effects of Xiantu Heche recipe combined with electroacupuncture in the treatment of premature ovarian failure with kidney deficiency and liver stagnation syndrome. Methods 60 patients with premature ovarian failure with kidney deficiency and liver stagnation syndrome were randomly divided into the treatment group (30 cases, treated with Xiantu Heche recipe combined with electroacupuncture)and control group (30 cases, treated with estradiol valerate and medroxyprogesterone),with a course of 3 months. The clinical efficacy was observed, the levels of Follicle Stimulating Hormone (FSH), Luteinizing Hormone (LH), Estradiol (E2) were compared before and after treatment as well as the modified Kupperman score and endometrial thickness. Results: ①The total effective rate were 76.67% in the treatment group and 63.33% in the control group respectively. There was statistical significance between groups (P<0.05). ②Compared between groups after treatment, the decrease of the level of FSH,LH in the treatment group was more significant(P<0.05),while the increase of the level of E2 in the control group was more significant(P<0.05). ③Compared the difference before and after treatment between groups,the decrease of the modified Kupperman score in the treatment group was more significant(P<0.05),and the endometrial thickness changed more significantly than the control group(P<0.05). Conclusion: Xiantu Heche recipe combined with electroacupuncture could be used in the treatment of premature ovarian failure with kidney deficiency and liver stagnation syndrome,which restore the ovarian function,recover the balance of endocrine and improve the life quality of the patients.关键词：premature ovarian failure;kidney deficiency and liver stagnation syndrome;Xiantu Heche recipe;acupuncture and medicine combination;ovarian function
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发布时间：2022-08-31 - 摘要：Objective:To observe the clinical efficacy of “BushenHuoxue Tiaojing Decoction” in the treatment of hypomenorrhea after artificial abortion. MethodsNinety patients were divided into observation group and control grouprandomly(45 cases in each group), and treated with “Bushen Huoxue Tiaojing Decoction” and “Bazhen Yimu Granule”for three menstrual cyclesrespectively. Theclinical efficacy, endometrial thickness and hormone level before and after treatment and recurrence within follow-upone-year were observed. Results:①The total effective rate was 95.56% in the observation group and 62.22% in the control group; which the clinical efficacyof the observation group was better than the control group(P<0.05). ②After treatment, the thickness of the endometriaincreased in both groups(P<0.05), and the change was more significant in the observation group than the control group(P<0.05). ③After treatment, the levels of FSH, LH and E2significantly increased and the level of PRL significantly decreased in the observation group(P<0.05); the hormones level were improved more significantly in the observation group than in the control group(P<0.05). Conclusion:“Bushen Huoxue Tiaojing Decoction”could be used in the treatment of hypomenorrhea after artificial abortion by improving hormones level and increasing endometrial thickness.关键词：“BushenHuoxue Tiaojing Decoction”;artificial abortion;hypomenorrhea
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发布时间：2022-08-31 - 摘要：Objective:To observe the effects of antihyperosteogeny decoction in the treatment of cervical spondylosis with heat syndrome. Methods 60 cases of outpatients with cervical spondylosis (damp-heat syndrome) were divided into treatment group and control group,30 outpatients at each group. Outpatients in treatment group were given anti-hyperosteogeny decoction, while outpatients in control group were given anti-hyperosteogeny capsule,with a course of 4 weeks. Clinical efficacy was observed, and the changes of pain visual analogue scale (VAS) and cervical spine dysfunction index (NDI) were compared. Results: ①The clinical total effective rate was 86.67% in the treatment group and 53.33% in the control group respectively,which difference was statistically significant (P<0.05). ②There were significant differences in the level of NDI and VAS within each group before and after treatment (P<0.05). After treatment, the level of VAS and NDI in the treatment group decreased more significantly than the control group (P<0.05). Conclusion: Antihyperosteogeny decoction could be used for the treatment of cervical spondylosis with heat syndrome,which significantly improve the neck pain and dysfunction in patients.关键词：cervical spondylosis;damp-heat syndrome;antihyperosteogeny decoction;heat-clearing and blood-activating therapy;Jian Xie;treatment based on syndrome differentiation;Professor Yinyu Shi
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发布时间：2022-08-31 - 摘要：This paper presents the syndrome differentiation and treatment of chronic tension-type headache from the perspectives of wind, liver depression, phlegm, blood-stasis and deficiency.关键词：tension-type headache;endogenous headache;syndrome differentiation and treatment prescription
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发布时间：2022-08-31 - 摘要：Ganmai Dazao Decoction,from the articles related to Gynecological diseases in the Golden Chamber, was commonly used in the treatment of hysteria of woman syndrome. But ancient physicians had controversial over the type of “wheat”(whole wheat, wheat kernel or floating wheat) in this prescription. This article tried to find some information from the literature,clinical research data and the background on the development of agricultural science and technology in Han dynasty and infer the type of wheat. The type of wheat mentioned in the Golden Chamber should be concluded as the whole wheat. Floating wheat can be used for emergency, but wheat kernel can not be used. Clinical medication should be selected depending on the situation.关键词：Ganmai Dazao Decoction;whole wheat;light wheat
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发布时间：2022-08-31 - 摘要：Objective:To study the effect of different doses of JianYao-MiGu tablet on mice bone formation and BMP7 expression of bone marrow mesemnchymal stem cells (BMSCs) in mice during the osteogenetic differentiation process. Methods Sixty 1-month-old Kunming mice, male thirty and female thirty, were randomly divided into four groups of high-dose, middle-dose, low-dose, and saline group. All the mice were treated intragastrically and sacrificed after 8 weeks. The fourth lumbar vertebra (L4) was scanned by Micro-CT, The BMP-7 expression of each group were observed using immunohistochemical staining. Primary bone marrow-derived mesenchymal stem cells (BMSCs) were isolated and cultured in each group. Alkaline phosphatase (ALP) staining was performed to observe the osteogenic differentiation, and real-time quantitative PCR analysis was performed to observe the mRNA expression of BMP-7. Results: Compared to normal saline group, high-dose group improved mice vertebral three-dimensional structure, increased the activity of ALP, promoted the mRNA and protein expression of BMP-7 expression. Conclusion:High-dose JianYao-MiGu tablet could promote the expression of ALP in BMSCs and osteogenic differentiation, increase the expression of BMP-7, thus as to promote bone formation.
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发布时间：2022-08-31 - 摘要：Objective:To investigate the effect of Chinese Herbal Fumigant of “Cuyu Xunxi Formula” on wound healing in the early stage of rats and the mechanism of promoting healing based on experiment. Methods The whole layer skin defection model was established in Wistar rats. The rats were randomly divided into the following groups:Cuyu Xunxi Formula group, control group (rivanol), and blank control group (0.9% saline). The condition of wounds was observed. VEGF, VEGFR-1 VEGFR-2 expression in wound tissue was detected by Western blot, and expression of serum TNF-α and IL-6 was detected by ELISA. Results: The healing time had no significant difference between Cuyu Xunxi formula group and control group, and was shorter than the blank control group. There was no statistical significance of the observation indexes on the third day after operation (P>0.05). The healing rate, granulation growth and serum TNF-α, IL-6 lever in Cuyu Xunxi Formula group were better than those of the blank control group on the seventh day and fifteenth day (P<0.05). On the seventh day, the wound healing rate in Cuyu Xunxi Formula group was higher than that in control group, and there was no significant difference in VEGF, VEGFR-1 AND VEGFR-2 among all groups. Conclusion:The pathogenesis of early wound based on exuberance of heat-toxin and blood-stasis obstruction, Cuyu Xunxi Formula could obviously inhibit the expression of inflammatory factor TNF-α and IL-6 of early wound and promote wound healing.关键词：Cuyu Xunxi Formula;wound healing;rat
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发布时间：2022-08-31 - 摘要：Objective:To observe the effect of the decoction of activating blood and removing stasis and supplementing essence and marrow on the expression of HSP70 and HIF-1α in intracerebral hemorrhage (ICH) rats. Methods Eighty Wistar male rats were randomly divided into four groups:sham operation group, model group, control group and prescription group,with twenty rats in each group. The rat model of ICH was made by injecting autologous blood into caudate nucleus, and the neurological function of rats was evaluated. Rats in prescription group and control group were given drug intervention after waking up. The expression of HSP70 and HIF-1α were detected by immunohistochemistry. Results: The neurological function scores of rats in the prescription group and the control group were significantly improved, the expression of HSP70 was also increased significantly, the expression of HIF-1α was reduced significantly, the test results of the prescription group were better than the control group, the difference was statistically significant. Conclusion: The decoction of activating blood and removing stasis and supplementing essence and marrow can regulate the HSP70 and HIF-1α to reduce secondary injury after cerebral hemorrhage.关键词：intracerebral hemorrhage;the Methods of Activating Blood and Removing Stasis and Supplementing Essence and Marrow;HSP70;HIF-1α
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发布时间：2022-08-31 - 摘要：Objective:By observing the endogenous NGF-TrkA and characteristics of the downstream pathway of molecular genetic transcription, to explore the protection of acupuncture treatment on high intraocular pressure rabbits’ retinal ganglion cells. Methods Thirty healthy adult rabbits of New Zealand were randomly divided into normal group (n=8) and model group (n=22). High intraocular pressure model in rabbits was established using carbomer. Three rats in the model group were died due to surgery and anesthesia, and 3 rabbits were not successful. The remaining 16 rabbits were randomly divided into model control group (n=8) and acupuncture group (n=8). After two weeks, rabbits in acupuncture group received filiform needle treatment of “He gu (LI4), Jing ming (BL1), Qiu hou (Ex-HN07)” point, three times a week for 4 weeks, with a total of 12 times; Normal group and model group were untreated. After treatment, the eyeballs were enucleationed. The morphological changes of retina were observed by HE staining; NGF, TrkA and p75mRNA expression in retina was detected by RT-PCR; AKT protein expression in retina was detected by Weston-blot. Results: In the process of treatment, the average intraocular pressure was 20.86-22.23 mmHg in acupuncture group and 23.82-25.49 mmHg in model group; After building the model group, compared with normal group, there was significant difference in intraocular pressure at each time point of treatment group and model group. In model group, the whole retinal structure had obvious changes, the kernel layer and the outer nuclear layer were arranged between chaos, two layers of the boundary was not clear, and the kernel layer bipolar cells and outer nuclear layer number of rods and cones, the ganglion cell layer showed the nucleus spacing increases, the number was decreased. Compared with model group, the number of bipolar cell was stable, kernel layer and outer nuclear layer boundary was clear, nucleus ganglion cell layer spacing was decreased, and the number was increased in acupuncture group. The mRNA expression of NGF and TrkA in retina tissue was enhanced and p75mRNA expression was reduced; downstream signaling molecules AKT express was enhanced in acupuncture group compared with normal group and with model group. Conclusion:1.Acupuncture can stable intraocular pressure, relieve retinal pathological damage, stable number of ganglion cells and protect RGC in rabbit model with chronic high intraocular pressure. 2.Acupuncture can promote NGF- TrkA, reduce p75 mRNA expression in chronic high intraocular pressure model of rabbit, enhance the level of downstream signaling molecules phosphorylation.关键词：NGF-TrkA;p75;Akt;acupuncture;high intraocular pressure;retinal ganglion cells
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发布时间：2022-08-31 - 摘要：Objective:To establish a quantitative analysis of multi-components by single-marker (QAMS) HPLC method for the determination of five triterpenoid saponins in the intermediates of Bacopa monnieri. Methods BacopasideⅠwas used as the internal marker to establish relative correction factor (RCF) between BacopasideⅠand other four triterpenoid saponins, and RCF was used in the calculation of their content. Relative error was used in the appraisal of the result between external standard method and QAMS. Results: The RCF between BacopasideⅠand other four triterpenoid saponins were 0.980,0.747,1.046 and 0.836, respectively. The two methods did not show significant difference in assay results and the RCFs were reliable with the relative error less than 5%. Conclusion: The established QAMS method is feasible, accurate, simple and can be used as a method for the determination of multi-component index in the extract of Bacopa monnieri.关键词：Bacopa monnieri;quantitative analysis of multi-assessment by single marker (QAMS);relative correction factor (RCF);external standard method (ESM);BacopasideⅠ;Bacoside A;3;BacopasideⅡ;Bacopasaponin C isomer;Bacopasaponin C
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发布时间：2022-08-31 - 摘要：Tongue diagnosis is one of Traditional Chinese Medicine(TCM) diagnosis methods. With the development of optical technology and digital technology, objective research of the tongue image has been carried out on the indicators of tongue color,moist and crack depth by using a variety of color patterns. The mechanism and essential of tongue were deeply researched by the method of cytology, immunology, metabolomics, proteomics and so on.关键词：tongue image;objective research;essential research
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发布时间：2022-08-31 -
Research progress on chemical constituents and pharmacological effects of Acanthopanax sessiliflorus
摘要：Acanthopanax sessiliflorus is used as both food and medicine. Studies have shown that triterpenoids,lignans and flavonoids are the main effective chemical constituents.The modern pharmacology studies showed that it had various activities,such as anti-oxidation,anti-inflammation,anti-hypoxia and anti-tumor.In this paper,we summarized the chemical constituents and pharmacological activities of Acanthopanax sessiliflorus based on the research status at home and abroad,which provide references for further development and utiliation of Acanthopanax sessiliflorus.关键词：Acanthopanax sessiliflorus;chemical constituent;pharmacological activity- 3
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发布时间：2022-08-31
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