最新刊期
期 6 ， 2016
- 摘要：This article introduces professor Tong Xiaolin’s considerations on syndrome and treatment of spirit-system disorders and herbal prescription. Top energizer is derived from conventional triple energizer to establish “four-energizer and eight-system” theory. In this theory, it is thought that many mental and emotional conditions belong to spirit-system disorders and nervous conditions to marrow-system disorders. Differentiation and treatment system is set for top energizer to treat spirit-system disorders. Therapeutically, Professor Tong concentrates on combination of Chinese and western medicines and puts forwards the principles of herbal prescription on the basis of condition-target regulation.关键词：top energizer;four-energizer and eight-system;spirit-system disorder;condition-target combination
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发布时间：2022-08-31 - 摘要：This article mainly explores the relationship between “Bentun” and depression syndrome. It is considered that the manifestation of “Bentun” fits the specialty of depression syndrome; that the etiology of “Bentun” has the features of emotional factors; that the susceptible population of “Bentun” has the natural endowment of depression syndrome, and that the pathogenesis of “Bentun” is mostly related to the autonomic nervous dysfunction induced by psychological factors. All these description prompts that “Bentun” is essentially a part of the depression syndrome.关键词：depression syndrome;“Bentun”;dysphrenia and dysneuria;treatment from depression
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发布时间：2022-08-31 - 摘要：Based on non-addition theory, this paper expounds the therapeutic effects that “the wholism is greater than its parts”, and presents a comprehensive perspective for the treatment of chocolate cyst.关键词：ovarian chocolate cysts;non-addition theory;treatment
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发布时间：2022-08-31 - 摘要：Objective:With the help of software TCMISS(V2.5), the key acupuncture points for insomnia are determined by data retrieval on the basis of clinical literature. MethodsThe acupuncture points formula for insomnia between 1997 and 2015 were screened from CNKI database and then input into software TCMISS for data mining and analysis. Results:Totally there are 237 formulas in 86 articles selected for insomnia, involving 10 syndromes; the most common syndromes are heart-spleen deficiency(21.9%) and liver depression-forming fire(21.5%). The most frequently-used points are Shenmen(HT 7), Baihui(GV 20), Sanyinjiao(SP 6), Sishenchong(EX-HN 1) and Neiguan(PC 6). When the confidence score is set as 0.8 and support score as 47,3 formulas were screened; when the the relevancy is set as 8 and punishment degrees as 2,7 core point formulas are screened. Conclusion:The platform of TCMISS is a very useful tool for screening acupuncture formulas, and he key point formulas help clinical treatment for insomnia.关键词：insomnia;acupuncture;point;data mining;TCMISS
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发布时间：2022-08-31 - 摘要：This paper introduces Professor Ding Xueping’s clinical experience in the treatment of obesity. Professor Ding believes that spleen deficiency is the basic pathogenesis of this disease, accompanied by qi-blood and fluids insufficiency, phlegm-blood congestion, and pathogenic fire; that its treatment should be concentrate on nourishing spleen and accompanying methods.关键词：obesity;treatment from the spleen;famous doctor’s experience;Ding Xueping
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发布时间：2022-08-31 - 摘要：This paper introduced professor Chen Zhiwei’s experience in the syndrome differentiation and treatment of ischemic necrosis of the femoral head.It is believed that this necrosis was primarily caused by qistagnancy and blood stasis, liver-kidney deficiency, phlegm-dampness congestion, and qi-blood insufficiency; that its treatment lied in activatingqi-blood circulation, nourishing liver and kidney, dispelling dampness andunblocking blood-stasis, and enriching qi and blood, and corresponding medicines were presented.关键词：ischemic necrosis of the femoral head;Chinese medicine therapy;experience of famous doctors;Chen Zhiwei
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发布时间：2022-08-31 - 摘要：This article introduces Professor Tan Yong’s clinical experience in the treatment of vomiting in pregnancy. It is thought that vomiting in pregnancy is primarily differentiated into liver-stomach disharmony, accompanied by spleen-stomach deficiency and phlegm-damp obstruction; oral administration and herbal steaming work on it well. A proven case was presented for example.关键词：vomiting in pregnancy;Chinese medicine;herbal steaming;clinical experience;Tan Yong
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发布时间：2022-08-31 - 摘要：This paper analyzes the three prescriptions for consumptive diseases in Synopsis of Prescription of the Golden Cabinet from their composition, herbal dosage, indications, herbal combination and prescription syndromes. It is argued that the consumptive diseases are treated by balancing yin and yang in the therapeutic principle of Internal Medicine; that “Zhigancao Decoction”, “Xiao Jianzhong Decoction” and “Bawei Shenqi Pill” act to regulate yin and yang respectively in the upper, middle and lower energizer. It is proposed that these three prescriptions should be classified into yin-yang-nourishing prescriptions.关键词：consumptive disease;“Zhigancao Decoction”;“Xiao Jianzhong Decoction”;“Bawei Shenqi Pill”;triple energizer
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发布时间：2022-08-31 - 摘要：This paper organizes previous literature and presents the origin and evolution of the term “syndrome differentiation and treatment prescription”, which helps understand its concrete connotation and guide clinical practice.关键词：syndrome differentiation and treatment prescription;term;origin and evolution;texture study
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发布时间：2022-08-31 - 摘要：By careful organization and summarization of brain theory and brain disorders in Huangdi’s Internal Classic, this paper studies the brain’s ownership, shape, generation and function to reduce the brain in traditional Chinese medicine. It is thought that the brain disorders are usually caused by brain deficiency and pathogenic invasion, and its treatment concenrates on nourishing the kidneys. Central nervous disease, encephalopathy in modern medicine, differs from brain disorders in Chinese medicine and should be treated from the heart, liver and kidney.关键词：Huangdi’s Internal Classic;brain;theoretical study
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发布时间：2022-08-31 - 摘要：This paper studies Zhu Danxi’s ministerial fire theory on cyclic movement of six qi and theoretically concludes that ministerial fire consists of physiological fire and pathological fire, but stresses the pathological one; failure of this Fire to store leads to dysfunction of six-qi cyclic movement and ensuing disharmony between the heart and kidney. Meanwhile, this theory is proved from Zhu Danxi’s herbal prescription.关键词：Zhu Danxi;ministerial fire theory;six-qi cyclic movement;heart-kidney disharmony
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发布时间：2022-08-31 - 摘要：Objective:To observe the clinical efficacy of “Feiyanning Granule” in treating advanced lung cancer. Methods In this prospective, randomized and controlled trial, 60 non-small cell lung cancer patients with deficiency were randomly divided into treatment group and control group, 30 cases in each group. The treatment group was administered “Feiyanning Granule” for oral intake, while the control group took 10% of the dose of simultaneous treatment for 8 weeks. The clinical efficacy of solid tumor and changes of symptoms and syndrome in TCM and improvement of quality of life were observed, while the side effects and adverse reactions were monitored. Results:①The effective rate was 66.67% and disease control rate was 70.00% in the treatment group, and they were 0.00% and 43.33% in the control group. There was a significant difference in the curative effect in solid tumor between the two groups(P<0.05). ②After treatment, the scores of domains in EORTC QLQ-LC30 were statistically higher in physical functions, emotional functions and general health(P<0.05), while they changed little in the control group, with significant differences between the two groups(P<0.05). ③The improvement of domains in the symptoms of breathlessness, cough, fatigue, pain and insomnia in the treatment group were obviously reduced(P<0.05); the pain score was increased in the control group(P<0.05) and other scores changed little(P>0.05); there were great differences in above symptoms between the two groups after treatment(P<0.05). ④ The incidence rate of adverse reaction was 16.67% and 26.67% respectively in the treatment group and control group, with no difference between them(P>0.05); there were no significant abnormality in the hematopoietic system and liver-kidney function in these two groups. Conclusion:“Feiyanning Granule” is effective to elevate short-term efficacy in treating advanced lung cancer and improving the quality of life, without severe side effects.关键词：non-small cell lung cancer;Chinese medicine therapy;“Feiyanning Granule”
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发布时间：2022-08-31 - 摘要：Objective:To observe the clinical efficacy of “Zhisou Powder” and Symbicort Turbuhaler in the treatment of cough variant asthma(CVA). MethodsFifty subjects were randomized into control group and treatment group, 25 cases in each group. Control group was treated by Symbicort Turbuhaler, and treatment group was treated by Symbicort Turbuhaler and “Zhisou Powder”, with a course of 4 weeks. The main symptoms and lung function were observed before and after treatment. Results:After treatment, the scores of main symptoms such as cough and expectoration and total scores were reduced in both groups(P<0.05), with lower scores in the treatment group than in the control group(P<0.05); after treatment, the lung functions(FEV1, PEF variation rates) were improved strikingly in both groups(P<0.05), with more significant improvement in the treatment group than in the control group(P<0.05). Conclusion:“Zhisou Powder” with Symbicort Turbuhaler is effective to improve the clinical symptoms and lung function in the treatment of CVA.关键词：cough variant asthma;“Zhisou Powder”;lung function
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发布时间：2022-08-31 - 摘要：Objective:To observe the clinical efficacy of “Yangyin Huoxue Tongluo Decoction” in the treatment of chronic persistent bronchial asthma of yin-deficiency and blood-stasis. MethodsSixty subjects were randomized into treatment group(n=30) and control group(n=30); the treatment group was given “Yangyin Huoxue Tongluo Decoction” and the control group was given treated with seretide, with a course of three months. The clinical efficacy, TCM syndrome score, pulmonary function and EOS were assessed before and after treatment. Results:①The total effective rate was 86.67% in the treatment group and 66.67% in the control group, with better efficacy in the treatment group than in the control group(P<0.05). ②There was a significant difference in the TCM syndrome score between the two groups after treatment(P<0.05). ③After treatment, the lung function(FEV1% and FEV1/FVC) was improved more significantly in the treatment group than in the treatment group(P<0.05). ④After treatment, the EOS count was lower in the treatment group than in the control group(P<0.05). Conclusion: “Yangyin Huoxue Tongluo Decoction” acts to relieve clinical symptoms and improve lung function in the treatment of chronic persistent bronchial asthma of yin-deficiency and blood-stasis.关键词：bronchial asthma;stable stage;yin-deficiency and blood-stasis;“Yangyin Huoxue Tongluo Decoction”;lung function
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发布时间：2022-08-31 - 摘要：Objective:To evaluate the clinical efficacy of “Qingre Huatan Decoction” in treating asthmatic bronchitis and its influence on lung function. MethodsOne hundred and fifty-seven subjects were randomized into observation group(n=81) and control group(n=75), and treated by Procaterol Hydrochlorise Oral Solution; besides, they were treated respectively by “Qingre Huatan Decoction” and “Shegan Mixture”, with a course of 10 days. The clinical efficacy and lung function were observed. Results:The total effective ratewas 93.83% in the observation group and 86.84% in the control group, with no difference between them(P>0.05).After treatment, Rrs SO was obviously reduced in both groups(P<0.05), with lower level in the observation group than in the control group(P<0.05); the Crs SO was increased in both groups(P<0.05), with no difference between the two groups(P>0.05). Conclusion:“Qingre Huatan Decoction” is quite effective in treating infantile asthmatic bronchitis and improving lung function.关键词：asthmatic bronchitis;infant;“Qingfei Huatan Decoction”;“Shegan Mixture”;lung function
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发布时间：2022-08-31 - 摘要：Objective:To observe the clinical efficacy of “Huayu Decoction” and western medicine in the treatment of myocardial injury in patients with septic shock. MethodsSixty subjects were randomized into two groups, 30 cases in each group; the control group was treated just with conventional western medicine, and the treatment group was treated with “Huayu Decoction” and conventional western medicine. After 7-day treatment, the clinical efficacy and the levels of serum myocardial injury indexes (LDH and CK - MB, cTNI) were observed. Results:①The effective rate was 70.00% in the treatment group and 40.00% in the control group, with better efficacy in the treatment group than in the control group(P<0.05). ②Between before and 24 hours after treatment, there were no differences in the LDH and CK-MB levels in the two groups(P>0.05), but there was a difference in cTNI level in the two groups(P<0.05). Twenty-four hours after treatment, there was no statistical significance in the levels of LDH and CK - MB between the two groups(P>0.05), and significant difference in cTNI level between the two groups(P<0.05). Between before and 7 days after treatment, there were significant differences in the LDH and CK-MB levels in the treatment group(P<0.05), and there were striking differences in the LDH and cTNI levels in the control group(P<0.05). Seven days after treatment, there were statistical significances in the levels of LDH, CK-MB and cTNI between the two groups(P<0.05). Conclusion: “Huayu Decoction” with western medicine is effective to reduce myocardial injury and improve heart function in the treatment of myocardial injury in patients with septic shock.关键词：sepsis;shock;“Huayu Decoction”;Chinese rhubarb;Salvia miltiorrhiza;myocardial protection
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发布时间：2022-08-31 - 摘要：Objective:To observe the clinical efficacy of “Tangzu Formula” on diabetic foot ulcers. MethodsSixty cases of diabetic foot were randomly divided into treatment group(n=30) and control group(n=30). Besides the same conventional treatment, the treatment group was given oral “Tangzu Formula”, and the control group was given oral placebo granule, with a course of one month. The clinical efficacy, areas of ulcers, and WBC, Hs-CRP, D-glucan and FPG, 2hPG and HbA1C were observed. Results:①The total effective rate was 86.67% in the treatment group and 73.33% in the control group, with better efficacy in the treatment group than in the control group(P<0.05). ②After treatment, there were significant differences in the long and short diameters between the two groups(P<0.05). ③After treatment, there was statistical significance in 2hPG, WBC, Hs-CRP and D-glucan between the two groups(P<0.05), with lower levels in treatment group than in the control group(P<0.05). Conclusion: “Tangzu Formula” with western medicine is effective in treating diabetic foot ulcers by inhibiting inflammatory reaction and promoting ulcer healing.关键词：diabetic foot;ulcer;“Tangzu Formula”;inflammatory reaction;fungal infection;XI jiu-yi
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发布时间：2022-08-31 -
Clinical study on “Shi’s Liqi Guyao Decoction” in treating lumbar disc herniation of qi-blood stasis
摘要：Objective:To observe the clinical effects of “Shi’s Liqi Guyao Decoction” in the treatment of lumbar disc herniation(LDH) of qi-blood stasis. MethodsOne hundred and two LDH cases were randomly divided into control group and treatment group, 51 cases in each group. The control group was treated with Diclofenac Sodium Sustained Release Tablets, while the treatment group was treated with “Shi’s Liqi Guyao Decoction”, with a course of 21 days. The TCM syndrome score, pain VAS score and lumbar JOA score were observed before treatment and after treatment. Results:①Total 100 cases completed the clinical research, 50 cases in treatment group and 50 cases in the control group. ②The total effective rate was 94.00% in the control group and 80.00% in the treatment group, with a statistical difference between the two groups (P<0.05). ③There was a striking difference in TCM syndrome score between before and after treatment in the two groups(P<0.001), and between the two groups after comparison(P<0.001). ④There were significant differences in the differential value in the decrease of VAS score and increase of lumbar JOA between the two groups(P<0.05). Conclusion: “Shi’s Liqi Guyao Decoction” has satisfactory effects on lumbar disc herniation(LDH) of qi-blood stasis in relieving lumbago and improving lumbar performance.关键词：lumbar disc herniation;qi-and blood stasis;“Liqi Guyao Decoction”;Shi’s traumatology- 7
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发布时间：2022-08-31 - 摘要：Objective:To assess the clinical efficacy of electroacupuncture in combination with skin traction in the treatment of knee osteoarthritis. MethodsSixty subjects were randomly assigned into treatment group and control group, with 30 cases in each group; the treatment group was given electroacupuncture and skin traction, and the control group was given only electroacupuncture, with a course of four weeks. Lower-extremity alignment was evaluated using coronal tibiofemoral angle(CTA), and the HSS scores of both knees and clinical efficacy were evaluated. Results:After treatment, the coronal tibiofemoral angle and hospital for special surgery scores were increased in both groups(P<0.05), with more significant increase in the treatment group than in the control group(P<0.05). The total effective rate was 90.00% in the treatment group and 76.67% in the control group, with better efficacy in the treatment group than in the control group(P<0.05). Conclusion: Electroacupuncture with skin traction can relieve knee pain and motor dysfunction, improve knee varus deformity and restore knee mechanics balance in the treatment knee osteoarthritis.关键词：knee osteoarthritis;electroacupuncture;skin traction;clinical observation
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发布时间：2022-08-31 - 摘要：Objective:To observe the clinical efficacy of “Bushen Huoxue Tongluo Decoction” with hysteroscopic-laparoscopic hydrotubation in the treatment of tubal infertility of blood stasis. MethodsSeventy subjects were randomized into treatment group(50 cases) and control group(25 cases). Hysteroscopic-laparoscopic hydrotubation was given to the control group while “Bushen Huoxue Tongluo Decoction” was added to the treatment group after the hydrotubation surgery. The treatment period was 6 months, with 6-month follow-up in the treatment group(not including the pregnant patients), and the control group was surveyed for one year. The fallopian tube patency, TCM syndrome score and pregnancy rate were observed. Results:①The difference of fallopian tube patency between before and after treatment in both groups was statistically significant(P<0.05); the fallopian tube patency of treatment group was better in the treatment group than in the control group(P<0.05). ②The decrease of TCM syndrome score was more significant in the treatment group than in the control group after treatment(P<0.05).③The pregnancy rate was 48.00% in the treatment group and 20.00% in control group, with a difference between them(P<0.05). Conclusion: “Bushen Huoxue Tongluo Decoction” with hysteroscopic-laparoscopic hydrotubation is quite effective for tubal infertility of blood stasis in increasing pregnancy rate.关键词：tubal obstruction;female infertility;hysteroscopy-laparoscopy;“Bushen Huoxue Tongluo Decoction”;integrative Chinese & western medicine
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发布时间：2022-08-31 - 摘要：Objective:To evaluate the clinical efficacy of earacupuncture with abdominal respiration in the treatment of senile post-stroke insomnia. MethodsSeventy-four subjects were randomized into treatment group (n=38) and control group (n=36). All the cases were given conventional nursing care, and the treatment group was additionally given earacupuncture and abdominal respiration, with a course of four weeks. The clinical efficacy and the sleep quality was evaluated with Pittsburgh sleep quality index (PSQI) before and after treatment. Results:The overall effective rate was 91.67% in the treatment group and 84.21% in the control group, with better efficacy in the treatment group than in the control group(P<0.01). The PSQI score was decreased more significantly in the treatment group than in the control group(P<0.05, P<0.01). Conclusion:Earacupuncture with abdominal respiration can obviously improve senile post-stroke insomnia.关键词：earacupuncture;abdominal respiration;stroke;sleep dysfunction;senility
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发布时间：2022-08-31 - 摘要：From the perspectives of the feature of semen storage that it can store and discharge the semen, this paper details the etiology of seminal turbidity that it is caused by its failure to balance the storage and discharging, and subsequent susceptibility to dampness heat and blood stasis, and introduces the therapeutic principles and methods according to the different pathogenesis in the early, middle and late stages.关键词：semen storage;seminal turbidity;prostatitis;clinical experience
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发布时间：2022-08-31 - 摘要：This paper reviews the action features of heavy medicines in Chinese medicine, specifically calming liver to extinguish wind, calming heart to tranquilize spirit, downbearing stomach-qi adversity, inducing qi downwards, astringing and stemming, and softening-dissolving masses.关键词：heavy medicine;herbal action feature;materia medica
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发布时间：2022-08-31 - 摘要：Objective:This study aims to investigate the pathogenesis of ulcerative colitis (UC). The changes of IL-6 and STAT3 protein in colon of UC model rats were observed after intervention with STAT3 pathway inhibitor or/and by “Xianglian Pill”. MethodsOne hundred male Wistar rats were randomly divided into 5 groups:control group, model group, Chinese medicine group(“Xianglian Pill”), inhibitor group, and Chinese medicine plus inhibitor group. The experiment was performed in rats of UC induced by TNBS enema, and then AG-490 and “Xianglian Pill” were administered to rats by intraperitoneal injection and gavage respectively. Colonic mucosal tissue were observed and evaluated by light and electron microscopy. The expressions of IL-6 and STAT3 protein were tested by western blot. Results:There were many ulcers in the colon of UC model rats, the pathological changes in colonic mucosa such as inflammation, congestion and edema were observed in the colon of UC model rats by naked eye and microscope. The expressions of IL-6 protein and STAT3 protein were increased in the colon of UC model rats, while decreased in Chinese medicine group, inhibitor group and Chinese medicine plus inhibitor group. Conclusion: The abnormal expression of related factors in IL-6/STAT3 pathway is the molecular basis for the occurrence of ulcerative colitis. “Xianglian Pill” can regulate the IL-6/STAT3 pathway to inhibit activation of STAT3 in UC intestinal mucosa, and promote the apoptosis of inflammatory cells.关键词：ulcerative colitis;“Xianglian Pill”;IL-6/STAT3 signaling pathway
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发布时间：2022-08-31 - 摘要：Objective:To study the effects of “Chang Ji Tai” on 5-HT2A receptor (5-HT2AR), 5-HT7 receptor (5-HT7R) and transient receptor potential vanilloid type-1(TRPV1) of dorsal root ganglia in irritable bowel syndrome(IBS) rats of visceral hypersensitivity. MethodsSixty neonatal Sprague-Dawley rats were randomly divided into 6 groups:normal control group, model control group, positive control group, “Chang Ji Tai” low-dose group, middle-dose group and high-dose group. The IBS rats model of visceral hypersensitivity was induced by intrarectal acetic acid irritation in the latter 5 groups. During the period of making model capsazepine (TRPV1 antagonist) was intraperitoneally injected (2 μg/g) in positive control group 30 min before intrarectal irritation. Four weeks after the end of modeling, “Chang Ji Tai” with concentrations of respectively 2.5 g/kg, 5 g/kg and 10 g/kg were administered intragastrically every day in “Chang Ji Tai” each dose group respectively, while equivalent deionized water was administered intragastrically in the other three groups. After 4-week treatment, rectal balloon distension was applied to evaluate visceral hypersensitivity by score of abdominal withdrawal reflex (AWR). The levels of 5-HT2AR, 5-HT7R and TRPV1 in dorsal root ganglia were detected by immunohistochemistry. Results:Compared with the normal control group, the scores of AWR with the 40,0 and 80 mmHg pressure were significantly higher in model control group (P<0.01). Compared with the model control group, the scores of AWR with the 40 and 60 mmHg pressure were significantly lower in all “Chang Ji Tai” groups (P<0.05, P<0.01). The expressions of 5-HT2AR, 5-HT7R and TRPV1 of dorsal root ganglia in model control group were significantly higher than that in the normal control group (P<0.01). The expressions of 5-HT2AR, 5-HT7R and TRPV1 of dorsal root ganglia in all “Chang Ji Tai” groups were significantly lower than that in model control group (P<0.01). There was no significant difference between “Chang Ji Tai” high-dose group and normal control group in the levels of 5-HT2AR, 5-HT7R and TRPV1 of dorsal root ganglia (P>0.05). Conclusion: “Chang Ji Tai” can reduce the visceral hypersensitivity by regulating the expressions of 5-HT2AR, 5-HT7R and TRPV1 of dorsal root ganglia.
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发布时间：2022-08-31 - 摘要：Objective:To estimate the hypoglycemic effects of the alcohol extract from the leaves of Rhus Typhina (TLEEP) in vitro and in vivo. MethodsIn vitro experiment, the effects of TLEEP on the activity of alpha-glucosidase were observed. In vivo experiment, diabetic model was induced by streptozocin (STZ) in male Kunming mice. The model rats were then divided into the following groups:model control group, positive control group 1 (acarbose group 6.66 μg·g-1·d-1), positive control group 2 (Xiaoke pill group 390 μg·g-1·d-1) and low-, medium-, high-dose of TLEEP group (200,0, 800 μg·g-1·d-1). Each group had 10 rats, and received 3-week treatment. After treatment, the blood was taken from the eyes to detect serum insulin, blood lipid (TG, TC, HDL-C, LDL-C), hepatic glycogen, and the sugar tolerance. Results:The results of in vitro experiment showed that TLEEP (0.4 g·L-1) inhibited the activity of alpha-glucosidase by 91%, with significant inhibition of alpha-glucosidase activity. The results of in vivo experiments showed that TLEEP, especially the high-dose TLEEP significantly reduced the blood glucose of model mice. The TLEEP significantly improved the serum insulin level and hepatic glycogen content, reduced serum levels of TC, TG and LD-C(P<0.05), and improved the HDL-C content (P<0.05) of model mice. Conclusion: TLEEP can markedly decrease blood glucose and improve the lipid metabolism disorders in STZ-induced diabetic mice. The TLEEP is a natural herb with potential hypoglycemic activities.关键词：alcohol extract from the leaves of Rhus Typhina;antihyperglycemic effect;in vitro;in vivo
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发布时间：2022-08-31 - 摘要：Objective:To investigate the effects of Saikosaponin d (SSd) on mitochondrial transmembrane potential (△ψm) and apoptosis in human neuroblastoma cells (SH-SY5Y). MethodsSH-SY5Y cells were cultured in high glucose DMEM; and SSd was dissolved in DMSO. SH-SY5Y cells were co-cultured with 0~10 μmol/L SSd for 48h. the △ψm of SH-SY5Y cells were analyzed with flow cytometry by Rh123 staining. At the same time, apoptosis levels of cells were analyzed by acridine orange (AO)/ethidium bromide (EB) staining and TUNEL Kit. Results:The fluorescence intensity of Rh123 was reduced significantly in SH-SY5Y cells after treatment with SSd for 48 h. It also showed that 8-10 μmol/L of SSd induced the increase of apoptotic index of SH-SY5Y cells by TUNEL staining (P<0.01). Conclusion: SSd can promote the apoptosis of SH-SY5Y cells by reducing △ψm.关键词：saikosaponin d;SH-SY5Y cells;△ψm;apoptosis
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发布时间：2022-08-31 - 摘要：Objective:To use the polytene component (6E,12E)- Tetradecadiene-8,0-diyne-1,3-dioldiacetate (TDEYA) and sesquiterpene component selina-4(14),7(11)-dien-8-one in Atractylodis Japonicae Rhizoma as the control chemicals to establish a TLC qualitative method and a HPLC quantitive method. MethodsTLC method:place samples and control chemicals on pre-coated TLC plate (SIL G-25 UV254); use petroleum ether-ethyl acetate=10:1 as development solvent. The TCL plate was observed under 254 nm UV lamp. HPLC method:ZORBAX SB-C18 (250 mm×4.6 mm, 5 μm); mobile phase:methanol-1% formic acid solution (67∶33); samples were detected under 254 nm ultraviolet lamp; flow rate:1.0 ml/min; column temperature:30 ℃; injection amount:10 μl. Results:The polytene component TDEYA and sesquiterpene component selina-4(14), 7(11)- dien-8-one were separated well by TLC and HPLC. This method could be used as the qualitative and quantitative methods of evaluating Atractylodis Japonicae Rhizoma. Conclusion: This method is simple in operation, accurate in results and good in reappearance, and can be used as the detection method for evaluating the quality of Atractylodis Japonicae Rhizoma.关键词：Atractylodis Japonicae Rhizoma;(6E,12E)-Tetradecadiene-8,0-diyne-1,3- dioldiacetate;selina-4(14), 7(11)- dien-8-one;TLC;HPLC
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发布时间：2022-08-31 - 摘要：This paper reviews the progress on Chinese medicine fighting against chemotherapy-induced cardiotoxicity. Anthracycline compounds are the major factors in chemotherapy-induced cardiotoxicity. It is found that some single herb, herbal prescriptions and herbal injections are effective against anthracycline-induced cardiotoxicity.关键词：anthracycline;doxorubicin;cardiotoxicity;cardiomyopathy;Chinese medicine
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发布时间：2022-08-31 - 摘要：This paper reviews the pharmacological mechanisms of active ingredients of heat-clearing herbs in fighting pancreatic cancer, specifically inhibiting the proliferation of pancreatic cancer cells, promoting cell apoptosis, suppressing angiogenesis, preventing tumor metastasis and increasing the sensitivity to chemotherapeutic drugs.关键词：pancreatic cancer;heat-clearing herb;active ingredient;pharmacological mechanism;review
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发布时间：2022-08-31
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