最新刊期
期 5 ， 2016
- 摘要：This paper introduces and summarizes the experience with differentiation and treatment of knee osteoarthritis in Shi’s Traumatology. It is argued that knee osteoarthritis is due to flaccidity and/or obstruction in pathogenesis; its treatment focuses on internal and external intervention, and sinew and bone by regulating qi and blood, nourishing liver and kidney, dissolving bloodstasis and removing phlegm. One proven case was presented.
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发布时间：2022-08-31 - 摘要：This paper presents the etiology, pathogenesis, manifestations and treatment of dyspnea and cough due to depression syndrome. It indicates that dyspnea and cough can be one of the manifestations of depression syndrome. Terror, anxiety, depression, angry and sorrow can all lead to dyspnea and cough. Dyspnea and cough due to depression syndrome has direct clinical evidences(emotional symptoms),as well as indirect clinical evidences such as neurotic personality and multiple systemic symptoms. In nature, it is a kind of masked depression syndrome covered by dyspnea and cough. The dyspnea and cough due to depression syndrome have been proved to be objectively existed by modern psychology, pathophysiology, epidemiology and clinical researches. In dealing with intractable dyspnea and cough, we need to pay attention to the possibility of dyspnea and cough due to depression syndrome and then try to treat it from depression.关键词：depression syndrome;dyspnea;cough;clinical feature;treatment from depression
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发布时间：2022-08-31 - 摘要：The evolution and development of cervical position-fixed rotating manipulations is presented in accordance with the 28 Tuina textbooks between 1959 to 2015. It is held that the rotating manipulation develops from fewer to more descriptions, from simple methods to complex methods in radiating mode; the manipulations are increasingly standardized and improved.关键词：cervical position-fixed rotating manipulation;textbook;developmental process;standardization
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发布时间：2022-08-31 - 摘要：Objective:To develop the risk questionnaire according to TCM symptoms associated possible factors asymptomaticlower extremity atherosclerosis(LEAD) in an attempt to increase early diagnosis. MethodsTwo hundreds subjects were surveyed with the risk questionnaire about asymptomatic LEAD based on ultrasound and ABI as positive diagnostic markers, which were then analyzed. Results:①The area below ROC curve of simple ABI was 0.867, the area of simple TCM symptoms 0.896 and the area of simple risk factors 0.864. ②In combination with TCM symptoms and risk factors, the area of predicted probability under the curve was 0.955.③ When TCM syndrome score scale weight was 0.7 and risk factors score scale weight was 0.3, the diagnostic value was highest, the area under the curve was 0.956 and the Youden index was 0.780.Transferred by the correction formula, the critical value was 40.83. Conclusion:Combination of TCM symptoms and risk factors can be used for the diagnosis and screening of asymptomaticlower extremity atherosclerosis.
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发布时间：2022-08-31 - 摘要：This article introduces professor Wang Dazeng’s experience in the treatment of recurrent abortion with kidney-nourishing, blood-activating and fetus-quieting therapy. Before pregnancy, nourishing therapy is given by “Taishan Panshi Powder”; and after pregnancy, fetus-quieting therapy is given by “Bushen Huoxue Antai Decoction”. One proven case is presented as example.关键词：recurrent abortion;kidney-nourishing, blood-activating and fetus-quieting therapy;clinical experience;Wang Dazeng
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发布时间：2022-08-31 - 摘要：This article summarizes professor Yan Xin’s clinical experience in applying the spleen-stomach theory. Professor Yan attaches great importance to the physiological function of spleen and stomach, and identifies the pathogenesis in spleen-stomach dysfunction to treat complicated conditions in multiple systems.关键词：miscellaneous diseases;spleen-stomach theory;Menghe medicine school;Yan Xin
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发布时间：2022-08-31 - 摘要：This paper introduces Gao Jining’s experience in the treatment of chronic renal failure. It is held that chronic renal failure should be treated primarily based on the kidney and other viscera from the dampness and blood-stasis. One proven case was presented.关键词：chronic renal failure;flexible treatment on prescription;clinical experience;Gao Jining
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发布时间：2022-08-31 - 摘要：This paper identifies the differences and commonality between “Zhuling Decoction” and “Wuling Powder” in pathogenesis, prescription-syndrome, herbal combination and clinical application to ascertain their clinical application.关键词：“Zhuling Decoction”;“Wuling Powder”;clinical application
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发布时间：2022-08-31 - 摘要：This article analyzes the differentiation and treatment features of Xiaoke condition in Peculiar Records in Syndrome Differentiation. Xiaoke condition is classified into lung Xiaoke condition, stomach Xiaoke condition and kidney Xiaoke condition, and respectively treated by cultivating earth to nourish metal, replenish water to suppress earth and intervening yin from yang with “Qingshang Zhixiao Pill”, “Biguan Zhike Decoction” and “Yinlong decoction”.关键词：Xiaoke condition;Peculiar Records in Syndrome Differentiation;lung Xiaoke condition;stomach Xiaoke condition;kidney Xiaoke condition
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发布时间：2022-08-31 - 摘要：Elucidation on Complicated Symptoms was a clinical book written in the Ming Dynasty. This paper introduces the book from the author’s life, version, main contents and academic characteristics. The contents of this book were modified and improved through later generations. This book detailed the etiology and pathogenesis, pulse, syndrome differentiation and herbal treatment from “stroke” to “chills”, among which the treatment of abdominal masses was unique and helped clinical treatment.关键词：Elucidation on Complicated Symptoms;Dai’s medicine;Chinese medicine
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发布时间：2022-08-31 - 摘要：Objective:To observe the clinical effects of “Qingre Jiedu Mixture” with transcatheter arterial chemoembolization(TACE) in treating advanced hepatocellular carcinoma(HCC). MethodsSixty patients with advanced HCC were randomly divided into treatment group and control group, with 30 cases in each group. All the patients were treated with TACE, and the patients in the treatment group were treated with “Qingre Jiedu Mixture” after TACE in three to seven days for eight weeks. The effect was evaluated after eight weeks. The clinical effect of solid tumor, quality of life, toxicity reaction and survival rate were observed. Results:The effective rates on solid tumor were 6.7%% and 3.3% respectively in the treatment group and control group; the control rates on solid tumor were 70.0% and 63.33% respectively in the treatment group and control group, with no statistical difference between the two groups(P>0.05). After treatment, the qualities of life, including fatigue, nausea and vomiting, appetite loss and constipation, were higher in the treatment group than in the control group(P<0.05). The incidences of nausea and vomiting were 23.3% and 50.0% in the treatment group and control group, with a statistical difference between the two groups(P<0.05). The survival rate in six months of treatment group (70.97%) was higher than that of the control group(53.33%)(P<0.05); the survival rate in one year of treatment group(45.16%) was was also higher than that of the control group(36.67%)(P<0.05). Conclusion:“Qingre Jiedu Mixture”with TACE can enhance the quality of life, reduce the side effects of TACE and increase the survival rates in six months and one year in treating patients with advanced hepatocellular carcinoma.关键词：advanced hepatocellular carcinoma;“Qingre Jiedu Mixture”;transcatheter arterial chemoembolization(TACE)
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发布时间：2022-08-31 - 摘要：Objective:To estimate the clinical effect of the “Gutongling Decoction” with “Feiyanning Decoction” and chemical drug in the treatment of pain caused by bone metastatic pulmonary cancer. MethodsTotal 100 patients with bone metastatic pulmonary cancer, who were identified as essence deficiency ones and suffered moderate or severe pain, were randomly divided into 51 cases as treatment group and 49 cases as control group. All patients were given the fundamental analgesic treatment. Besides, the patients in control group were treated with zoledronic acid and “Feiyanning Decoction” additionally, while the treatment group was also given “Gutongling Decoction”. Both groups were treated for 2 months. The analgesic effect and safety of the medicine were observed and the score used for the evaluation of life quality and physical situation of patients were compared as well as the level of serum calcium and alkaline phosphatase. Results:①Ninety-eight cases completed the whole trials at last, 50 cases in the treatment group and 48 cases in the control group. ②The total analgesic efficiency was 80% in the treatment group and 54.17% in control group, and the analgesic effect in the treatment group were significantly increased compared with control group (P<0.05). ③The score difference in physical function, role function, social function, health status, fatigue, and insomnia in the core scale of life quality was statistically significant between two groups after treatment(P<0.05), as well as the score in the chest pain and pains in other parts in the lung cancer specific sub scale(P<0.05). ④The difference of physical condition score was statistically significant between two groups after treatment(P<0.05), and the improvement rate of the treatment group was significantly higher than that of the control group (P<0.05). ⑤Compared within each group and between two groups before and after treatment, the difference of serum alkaline phosphatase levels were statistically significant (P<0.05). ⑥There was no significant difference in adverse reactions between two groups(P>0.05). Conclusion:The “Gutongling Decoction” with “Feiyanning Decoction” and chemical drug are effective to relieve pain and improve life quality by inhibiting alkaline phosphatase in the treatment of pain caused by bone metastatic pulmonary cancer.关键词：lung cancer;bone metastasis;Gutongling Decoction;pain relief;quality of life;alkaline phosphatase
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发布时间：2022-08-31 - 摘要：Objective:To observe the clinical effects of “Xingqii Lishui Powder” on topical treatment of malignant ascites. MethodsSixty subjects were randomly divided into treatment group and control group, 30 cases in each group. The control group was treated with spironolactone and furosemide tablet, and the treatment group was treated by “Xingqi Lishui Powder” on navel compression besides the treatment in the control group, with a course 10 days. The TCM symptom score and abdominal pain score were observed before and after treatment. Results:①The effective rates of treatment group and control group were 73.33% and 13.33% respectively, with better effects in the treatment group than in the control group(P<0.05). ②There were striking differences in TCM syndrome score and abdominal pain score between before and after treatment in both groups(P<0.05); after treatment, there was a significant difference between treatment group and control group(P<0.05). Conclusion:“Xingqi Lishui Powder” on navel compression in effective to treat cancerous ascites in relieving ascites and improving the quality of life.关键词：cancerous ascites;“Xingqi Lishui Powder”;navel therapy;internal disease treated by external application
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发布时间：2022-08-31 - 摘要：Objective:To observe the clinical effects of “Yangyin Huatan Xifeng Decoction” in the treatment of recurrent hepatic encephalopathy. MethodsEight-six subjects were randomly divided into treatment group and control group, 43 cases in each group. Control group was treated with rifaximin and lactulose, while treatment group was given “Yangyin Huatan Xifeng Decoction”, with a course of 6 months. The occurrence of hepatic encephalopathy was observed and the number-connection test and the plasma level of ammonia were compared during the treatment. Results:①Seventy-four cases completed the whole trials, among which 37 cases were in treatment group and 37 cases were in control group. ②During the course of treatment, the average attack times of hepatic encephalopathy in the treatment group were significantly fewer than that of the control group(P<0.05). ③The differences of NCT-A test time, DST test scores and blood ammonia levels within each group before and after treatment were statistically significant(P<0.05). But there were no significant differences in the NCT-A test time and DST test scores between two groups. Compared with the control group after treatment, the blood ammonia levels in the treatment group were significantly decreased(P<0.05). Conclusion:“Yangyin Huatan Xifeng Decoction” works well on recurrent encephalopathy in reducing the attack frequency and blood ammonia.关键词：hepatic encephalopathy;recurrent attack;“Yangyin Huatan Xifeng Decoction”;number-connection test
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发布时间：2022-08-31 - 摘要：Objective:To observe the influence of Safflower Injection on pulse wave velocity(PWV) and RAAS in patients with hypertension. MethodsOne hundred and twenty-eight subjects were randomized into control group and treatment group, 64 cases in each group. The control group was given conventional antihypertensive treatment, and the treatment group was given intravenous injection of Safflower Injection besides the antihypertensive treatment, with the course of 28 days. The clinical efficacy and the indicators related to pulse wave velocity(baPWV, cfPWV, faPWV) and RAAS (ALD, Ang-I, Ang-II, PRA) before and after treatment were observed in both groups. Results:①The total effective rate was 70.31% in the control group and 89.06% in the treatment group, with better efficacy in the treatment group than in the control group(P<0.05). ②After treatment, the baPWV, cfPWV and faPWV were reduced in both groups(P<0.05, P<0.01), with more significant reduction in the treatment group than in the control group(P<0.05). ③After treatment, the levels of ALD, Ang-Ⅰ, Ang-Ⅱand PRA were decreased in both groups(P<0.05, P<0.01), with more significant decrease in the treatment group than in the control group(P<0.05). Conclusion:Safflower Injection helps fighting hypertension by reducing the indicators related to PWV and RAAS in patients with hypertension.关键词：hypertension;pulse wave velocity;renin-angiotensin-aldosterone system;Safflower Injection
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发布时间：2022-08-31 - 摘要：Objective:To observe the clinical efficacy and safety of “Yiqi Jiedu Quyu Decoction” and thalidomide in the treatment of Behcet’s disease. MethodsForty cases of Behcet’s disease of qi-deficiency and blood-toxin were randomized into two groups:control group in which 20 cases were treated with thalidomide at the dose of 50mg/d, and treatment group in which 20 cases were treated with “Yiqi Jiedu Quyu Decoction” and thalidomide, with a course of three months. The clinical efficacy, attack frequency of oral ulcers, remission period and oral ulcers, ESR, C-reactive protein and side effects were observed. Results:The total effective rate in the treatment group(95.00%) was higher than that in the control group(85.00%), with a significant difference between them(P<0.05). After treatment, the the oral ulcers, ESR and C-reactive protein were improved in both groups(P<0.05), with longer remission period and lower ESR in the treatment group than in the control group(P<0.05); the incidence of side effect in the treatment group(5%) was lower than that in the control group(25%)(P<0.05). Conclusion:“Yiqi Jiedu Quyu Decoction”with thalidomide is quite effective and safe for Behcet’s disease in lowering ESR and prolonging remission period of oral ulcers.关键词：“Yiqi Jiedu Quyu Decoction”;Behcet’s disease;Huhuo disorder;integrative Chinese & western medicine
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发布时间：2022-08-31 - 摘要：Objective:To observe the effects of Xu Xiao-pu’s empirical formula in the internal and external treatment for herpetic stomatitis in children with syndrome of accumulated heat in heart and spleen. MethodsSixty subjects were randomly divided into treatment group and control group, 30 cases in each group. The patients in control group were treated with Ribavirin Aerosol combined with Pudilan oral liquid, and the treatment group were treated with Xu Xiao-pu’s empirical formula via internal and external application. Two groups were treated for 6 days. Clinical efficacy and safety were observed, and the time for clinical symptoms relief was compared. Results:①After treatment for 6 days, the total effective rate was 100% in both groups. The clinical cure rates were 66.67% in the treatment group and 46.67% in the control group, with significant difference between the two groups(P<0.05). ②Compared between two groups, the occurrence of herpes regression, abnormal diet and fever symptoms were significantly different (P<0.05), but there was no significant difference in the time of salivation(P>0.05). ③There were no obvious adverse reactions in two groups. Conclusion:Xu Xiao-pu’s empirical formula in internal and external treatment is quite effective for herpetic stomatitis in children with syndrome of accumulated heat in heart and spleen,and relieve clinical symptoms.关键词：herpetic stomatitis;child;aphtha;accumulated heat in heart and spleen;Heat-Clearing and Spleen-Purging Powder;Jinbuhuan Aphtha Powder;Xu Xiaopu
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发布时间：2022-08-31 - 摘要：Objective:To evaluate the clinical effects of “Jiawei Zuogui Pill” in the treatment of postmenopausal osteoporosis of kidney-yin deficiency. MethodsEighty subjects were randomly divided into two groups. The treatment group(40 cases) was treated with “Jiawei Zuogui Pill” and calcium carbonate D3, while the control group (40 case) was treated with calcium carbonate D3 only . Both groups were treated for one year. The changes of bone mineral density(BMD) (L2-L4 and hip femoral neck and Ward’s triangle), the score of traditional Chinese Medcine(TCM) syndrome, estradiol (E2), 25 hydroxy vitamin D3 [25 (OH)VitD3], antitartaric acid phosphatase (TRACP), bone alkaline phosphatase (BALP) and other biochemical indexes were compared. Results:①The level of BMD(L2-L4, neck of femur and Ward’s region) increased significantly in treatment group compared with control group after treatment(P<0.05). ② Compared before and after treatment within groups, the score of TCM syndrome in each group decreased significantly(P<0.05). Compared with the control group, the reduction of the score in treatment group was more remarkable(P<0.05).③Compared before and after treatment, the level of 25(OH)D3 increased significantly(P<0.05), while TPACP and BALP decreased significantly(P<0.05) in treatment group. There was no significant change in control group. Conclusion:“Jiawei Zuogui Pill” can increase BMD and relieve the symptoms of kidney-yin deficiency in the treatment of postmenopausal osteoporosis.
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发布时间：2022-08-31 - 摘要：Objective:To investigate the impact of herbal menstruation-regulation therapy on sex hormones and ovarian artery blood flow in patients with diminished ovarian reserve. MethodsSeventy-four subjects were divided into two groups:control group in which 37 cases were treated by climen, and treatment group in which 37 cases were treated by climen and herbal menstruation-regulation therapy, with a course of three months. The levels of sex hormones and ovarian artery blood flow were detected before and after treatment. Results:After treatment, the levels of FSH, LH and E2 were decreased significantly in both groups(P<0.05), with lower levels in the treatment group than in the control group (P<0.05). After treatment, the resistance indexes of ovarian artery blood flow were reduced in both groups(P<0.05); the peak systolic velocity(PSV) of ovarian artery blood flow was elevated in both groups(P<0.05), with higher velocity in the treatment group than in the control group (P<0.05). Conclusion:Herbal menstruation-regulation therapy helps reducing sex hormones and improving ovarian artery blood flow in patients with diminished ovarian reserve.关键词：decreased ovarian reserve;herbal menstruation-regulation therapy;“Bushen Tiaojing Decoction”;“Tiaojing Decoction”;sex hormone;ovarian artery blood flow
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发布时间：2022-08-31 - 摘要：This paper presents the etiology and pathogenesis of vertigo of phlegm-fluids accumulation and the herbal combination of “Gegen Zixie Decoction”. Typical cases were analyzed to introduce the clinical experience.关键词：vertigo of phlegm-fluids accumulation;“Gegen Zexie Decoction”;clinical application
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发布时间：2022-08-31 - 摘要：Based upon previous literature, this paper presents the actions and indications of jobstears seed, specifically nourishing spleen and disinhibiting dampness, smoothing joints, clearing heat and discharging pus, and fighting tumor mass.关键词：jobstears seed;nourishing spleen and disinhibiting dampness;smoothing joints;clearing heat and discharging pus;fighting tumor mass
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发布时间：2022-08-31 - 摘要：Objective:To observe the effects of “Shidao Tongjie Decoction”(SDTJ) on cell proliferation and apoptosis of esophagus cancer cell line (TE-1) in vivo, and further investigate the mechanism of action of SDTJ in the treatment of esophagus cancer. MethodsTE-1 cells were inoculated subcutaneously into the nude mice. The nude mice bearing tumor were then randomly divided into the following 4 groups:model group, SDTJ group, cisplatin group and combination group (SDTJ combined with cisplatin), with 10 mice in each group:The mice in each group were administrated by gastric infusion for 2 weeks. Then the mice were executed, the tumor weight and the inhibition rate were calculated. The change of TE-1 cells morphology and apoptosis were observed by HE staining; Protein expressions of Bcl-2 and caspase3 were detected by immunohistochemical method. Results:The tumor weight of the three treatment groups was all lower than that of the model group(P<0.01), the tumor inhibition rate was 49.95%, 48.65% and 56.76% respectively; there’s no statistical significance (P=0.346) in tumor weight between SDTJ group and cisplatin group; the tumor weight of the combination group was lower than SDTJ group(P<0.01). In the form changing aspect, the SDTJ group and combination group had the lower cell density, the shape of the cells was roundness or elliptical, the atypical epithelial hyperplasia hepatolithiasis was reduced, the combination group had the most prominent change. Immunohistochemical result showed that the expression of Bcl-2 in SDTJ group, cisplatin group and combination group was obviously lower than that in the model group, with the combination group having the lowest expression (P<0.01), and with no statistical significance (P=0.581) between SDTJ group and cisplatin group. The caspase 3 expression in SDTJ group, cisplatin group and combination group was obviously higher than that in model group, with combination group having the highest expression (P<0.01), and with no significant difference between SDTJ group and cisplatin group. Conclusion:Shi Dao Tong Jie formula could restrain the proliferation and promote the apoptosis of TE-1 esophagus cancer cell line, which may be related to the down-regulation of the Bcl-2 expression and up-regulation of the caspase 3 expression in the esophagus cancer cell line.关键词：“Shidao Tongjie Decoction”;esophagus cancer cell line;B-cell lymphoma-2’s expression (Bcl-2);cysteinyl aspartate specific proteinase 3’s expression (caspase 3)
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发布时间：2022-08-31 - 摘要：Objective:To investigate the reversing effects and mechanism of ursolic acid on drug resistance in nude mice bearing ovarian cancer stem cells. MethodsThe human ovarian cancer stem cells were enriched and collected from serum free cells suspension of Skov3 cells. Then the cells were inoculated subcutaneously into nude mice. The nude mice were treated with ursolic acid (high, medium and low dose), cisplatin, andcisplatin plus ursolic acid respectively for 14 continuous days. Tumor growth curve and inhibitory rate were calculated by daily measurement of tumor volume. Cell morphology and structure were observed by HE staining; ABCG2 expression was detected by immunohistochemistry and cell apoptosis was detected by the TUNEL method. Results:Ursolic acid inhibited tumor growth in a dose-dependent manner, and ursolic acid plus cisplatin group was superior to cisplatin group. Ursolic acid inhibited the expression of ABCG2, a drug rsisitance index, and promoted apoptosis of cancer stem cells, improved the ability of cisplatin-induced apoptosis. Conclusion:Ursolic acid can inhibit the tumor growth in nude mice transplanted with ovarian cancer stem cells by decreasing ABCG2 expression, promoting cell apoptosis, enhancing cisplatin-induced apoptosis.关键词：ursolic acid;ovarian cancer stem cells;tumor-bearing mice;drug resistance
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发布时间：2022-08-31 - 摘要：Objective:To observe the effects of electroacupuncture and morphine on hyperalgesia and the activation of spinal astrocyte in rats of bone cancer pain. MethodsSixty Wistar rats were randomly divided into sham operation group, model group, morphine group, electroacupunture group and electroacupuncture with morphine group, 12 rats in each group. From the 15th day after establishing models (inoculating rat mammary gland carcinoma cell Walker 256 into marrow cavity of tibia), the rats were treated accordingly by electroacupuncture and/or morphine once a day for 6 days. Paw withdrawal latency (PWL) was observed after treatments. Expressions of spinal GFAP, IL-1β and NGF were determined by Western blot method and immunofluorescent histochemical staining method. Results:①PWL was longer in the three treatment groups than in the model group (P<0.01), with longer PWL in electroacupuncture and morphine group than in morphine group and electroacupunture group (P<0.01). ②Compared with the model group, expressions of spinal GFAP and NGF in electroacupunture group and electroacupuncture with morphine group were reduced (P<0.01); expressions of spinal IL-1β in the three treatment groups were all reduced (P<0.01). Conclusion:Electroacupuncture with morphine is effective to suppress hyperalgesia in rats of bone cancer pain by inhibiting the activation of spinal astrocyte.关键词：electroacupuncture;acupuncture with medicine;cancer pain;acupuncture analgesia;astrocyte
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发布时间：2022-08-31 - 摘要：Objective:To investigate the effects of “Xiaoqinglong Decoction” (XQLD) on the airway remodeling and the expression levels of TGF-β1 and IL-13 in lung tissue of mice with asthmatic airway remodeling. MethodsForty healthy female BABL/c mice were randomly divided into four groups, which consisted of normal control group, asthmatic model group, XQLD group and prednisolone group. The mice were sensitized for 2 weeks and stimulated for 6 weeks by ovalbumin to establish the asthmatic airway remodeling mice model. XQLD group and prednisolone group were given XQLD or prednisolone before each stimulation for 6 weeks. The pathological changes were observed by slicing lung tissues and stained with HE. The thickness of bronchial wall and airway smooth muscle were measured by optical microscope and the Image-Pro Plus 6.0. The expressions of TGF-β1 and IL-13 in lung tissues were observed by immunohistochemistry and detected by Real-time quantitative PCR. Results:Bronchial wall thickened, inflammatory cell infiltration, smooth muscle hypertrophied and airway remodeled were found in asthmatic model mice. The thickness of bronchial wall and smooth muscle of XQLD group and prednisolone group were less than asthmatic model group. As the result of immunohistochemistry, there were weak expressions of TGF-β1 and IL-13 mainly on bronchial wall in normal control group. Compared with normal control group, the expressions of TGF-β1 and IL-13 were more obvious in asthmatic model group. The gene expressions of TGF-β1 and IL-13 of XQLD group and prednisolone group were significantly lower than asthmatic model group(P<0.05). Conclusion:The high expressions of TGF-β1 and IL-13 might play an important role in developing airway remodeling of asthma. “Xiaoqinglong Decoction” has some inhibitory effect on airway remodeling in asthmatic mice by inhibiting the expressions of TGF-β1 and IL-13 in lung tissues probably.关键词：asthma;“Xiaoqinglong Decoction”;transforming growth factor-β1(TGF-β1);interleukin 13(IL-13)
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发布时间：2022-08-31 - 摘要：Objective:To investigate the effects and mechanisms of “Qufeng Zhitong Ointments” on adjuvant arthritis (AA) in rats. MethodsArthritis severity was evaluated by body weight loss, paw swelling, arthritic score, and histological changes. In addition, the serum levels of TNF-α, IL-1, SOD, MDA, GSH and NO were detected using ELISA method. Another portion of blood was used for blood routine examination . The expressions of MMP-10 and VEGF in rat cartliage tissue were detected using immunohistocheical analysis. Moreover, the cell culture supernatants of celiac macrophage cells isolated from AA rats with or without treatment of the medicine were added to mice thymic cells and rats splenic cells, and the proliferation of mice thymic cells and rats splenic cells were observed by MTT assay. Results:Compared with the model group “Qufeng Zhitong ointments” significantly ameliorated paw swelling and arthritis score, down-regulated the levels of MDA,IL-1,TNF-α,NO and up-regulated the SOD and GSH levels in serum(P<0.05,P<0.01). It also inhibited the proliferation of splenic cells and mice thymic cells, effectivelly releasedjoint hyperplasia, and down-regulated MMP-10 and VEGF expression in crtliage tissue(P<0.05,P<0.01). Conclusion:The results showed that Qufengzhitong ointments has good effect on adjuvant arthritis, the mechanism may be related to recucing oxidative damage, inhibitng MMP-10 and VEGF expression.关键词：“Qufeng Zhitong Ointments”;adjunct arthritis;rat
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发布时间：2022-08-31 - 摘要：Objective:To develop a new, simple and reproducible method for the quality control of Banxia Xiexin Decoction gastric retention tablets. MethodsTLC was performed for qualitative identification of Scutellaria baicalensisand and Rhizoma Coptidis. HPLC was used for the quantitative analysis of drug release in vitro and determination of baicalin and berberine hydrochloride. Baicalin was quantified on a Diamonsil C18 column using a mixture of methanol-water-phosphoric (47:53:0.2, v/v/v) as the mobile phase with UV detection at 280 nm, and berberine hydrochloride was quantified using acetonitrile-0.05 mol/L potassium dihydrogen phosphate (50:50, v/v) as the mobile phase with UV detection at 345 nm. Results:Calibration curves were linear in the concentration range of 4~20 μg/mL of baicalin (Y = 40763X-54322, R2=0.9991) and of 5~25 μg/mL of berberine hydrochloride (Y = 62471X-16359, R2=0.9997), respectively. The results of methodology study were in line with the requirements. The content of baicalin and berberine hydrochloride was validated to be 19.95±0.72mg / tablet and 13.02±1.05 mg / tablet by determining six batches of Banxia Xiexin Dectotion gastric retention tablets. The release time was confirmed to be 2h, 6h and 10h. After 10h, the release rate was greater than 90%. Conclusion:A sensitive, reliable, easy and reproducible method was established for qualitative and quantitative analysis of Banxia Xiexin Decoction gastric retention tablets, with the sampling point in accordance with Pharmacopoeia. The method is suitable for the quality control of Banxia Xiexin Decoction gastric retention tablets.
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发布时间：2022-08-31 - 摘要：This paper reviews the research of mechanism of action and research progress of Chinese herbal medicine in the treatment of steroid-induced femoral head necrosis. Chinese herbal medicine in the treatment of steroid induced avascular necrosis of the femoral head function to promote bone formation, inhibit bone destruction, regulate lipid metabolism, improve blood rheology, promote blood vessel repair and regeneration, improve high coagulation, low fibrinolysis and endothelial cell damage.关键词：Chinese herbal medicine;steroid-induced avascular necrosis of femoral head;action mechanism;review
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发布时间：2022-08-31 - 摘要：This article summarizes the chemical compositions and pharmacologicaleffects of Viscum coloratum (Kom.) Nakai.The main chemical constituents include small molecule compounds such as flavonoids, triterpenoids and alkaloids, and macromolecular compound such as lectin and viscotoxin. Multiplepharmacological activities have been proved, such as the anti-tumor, immune regulation, antihypertension, antiarrhythmia and anti-myocardial ischemia.The aim of this article is toprovide references for further study and the rational use through clarifying the material basis of pharmacological action.关键词：Viscum coloratum (Kom.) Nakai;chemical composition;pharmacological action;research progress
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发布时间：2022-08-31
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