最新刊期
期 4 ， 2016
- 摘要：This paper introduces Professor Yan Juntao’s acdemic experience in treating Keen Osteoarthritis with Tuina on basis of theory of Jinjing and distinguishes the disease stage with differentiation. Professor Yan thinks that the muscle paralysis is the core. Touching on the outside is a way to identify Jinjing syndromes. It is the principle that gentle manipulation makes Jinjing smooth and forceful manipulation makes Jinjing tense. Point, line and surface are combined to characteristics treatment and Tuina manipulation. Gongfa Yi Jinjing can strengthen the function of Jinjing and knee.
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发布时间：2022-08-31 - 摘要：This paper explores the therapy and syndromes of numbness due to depression syndrome. It indicates that apart from disharmony between ying and wei,and qi and blood,phlegm-stasis obstruction,and wind-dampness obstruction,the pathogenesis of numbness can also be connected to anxiety,terror,depression,irascibility,heart vacuity and discomposure and so on,which can all lead to numbness,so we should treat numbness from the aspect of depression syndrome. The location,sensation,degree,beginning and ending time,attack,and associated symptoms of numbness due to depression syndrome all have similar characteristics as depression syndrome in different degree. Numbness due to depression syndrome can be found in many mental disorders,such as melancholia,panic disorder of anxiety neurosis,somatoform disorders,and limb perceive abnormality in modern medicine.关键词：depression syndrome;numbness;organic numbness;functional numbness;treating from the aspect of depression
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发布时间：2022-08-31 - 摘要：This paper discusses the statue of evaluation and diagnosis of sub-health state in view of scales questionnaire evaluation method, syndromes combination method, narration method, etc. It is stated that the evaluation and treating of sub-health can be studied from measuring of health, using scales questionnaire evaluation and digital mining, clinical quality controlling with various means and constructing micro and macro indexes complex evaluation system.
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发布时间：2022-08-31 - 摘要：Objective:To investigate effects of Electroacupuncture(EA)combined with general anesthesia(GA)strategy on oxygenation and pulmonary shunt during one-lung ventilation in patients with thoracic surgery. MethodsSixty patients with thoracic surgery were randomly divided into EA group and GA group,with 30 cases in each group.Patients of the GA group received simple general anesthesia.EA(2/100 Hz)was applied to bilateral Houxi(SI03),Zhigou(SJ6),Neiguan(PC6),and Hegu(LI4)beginning about 30 min before the surgery in the EA group.Blood samples were obtained at four time points:two lung ventilation 0 min(T0),one-lung ventilation 15 min(T1),one-lung ventilation 30 min(T2),one-lung ventilation 60 min(T3)via internal jugular vein and radial artery to perform blood gas analysis.Intrapulmonary shunt(Qs/Qt)was calculated and detected. Results:①Compared to the two lung ventilation(T0), there was no significant difference in the MAP, HR, CVP, Paw, pH, PaCO2, PvO2, SvO2, and Hb in both group during the one-lung ventilation(T1-T3)(P>0.05); There was also no significant difference between the two groups at the same time points(P>0.05). ②Compared to the T0, the partial pressure of oxygen(PaO2)was significantly reduced at T1, T2, and T3 in each group(P<0.05); In GA group, the PaO2 was reached the lowest value at T2 and then began to increase; However, in EA group, the PaO2 was reached the lowest value at T3; Meanwhile, compared to the GA group,the PaO2 was significantly higher at the time points T1,T2,and T3 in EA group(P<0.05); During the one-lung ventilation, there was no significant difference in SaO2 between the two groups at T1, T2, and T3(P>0.05). ③There was no significant difference in Qs/Qt between the two groups before surgery(P>0.05), and both were in the normal range. After one lung ventilation, Qs/Qt value increased significantly(P<0.05). The peak value of Qs/Qt in EA group was at 15 min(T1)after one lung ventilation, while the peak of pulmonary shunt occurred at 30 min(T2)in GA group. The Qs/Qt value in EA group was significantly lower than that in GA group at T1, T2, T3, with a significant difference between two groups(P<0.05). Conclusion:EA combined with general anesthesia can increase the PaO2 and reduce intrapulmonary shunt during one-lung ventilation in patients undergoing thoracic surgery.It has positive effects on lung protection in clinical practice.关键词：electroacupuncture combined with general anesthesia;one-lung ventilation;partial pressure of oxygen;pulmonary shunt fraction;lung protection
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发布时间：2022-08-31 - 摘要：Objective:To evaluate the economic value of Kuntai Capsule and hormones in the treatment of perimenopausal syndrome. Methods Articles of randomized controlled trial were enrolled and screened by Cochrane system from 2000 to 2015 years regarding Kuntai Capsule and hormones in the treatment of perimenopausal syndrome. The data were analyzed by Revman 5.3 software.to determine the effective rate, safety and cost. Results:①The clinical effective rate was higher of Kuntai Capsule than hormones(P<0.05); ②The safety was superior of Kuntai Capsule to hormones(P<0.05); ③With the increase of effective rate by 1%, the cost of Kuntai Capsule increased by 15.2 yuan, while the hormones by 12.5 yuan. Conclusion: Compared with hormones, Kuntai Capsule is efficient and safe in the treatment of perimenopausal syndrome. They can be used on individual condition.关键词：perimenopausal syndrome;menopausal hormone therapy;Kuntai Capsule;Kupperman score
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发布时间：2022-08-31 - 摘要：This paper discusses medical source and main treatment of Qianyang Fengsui Dan. Through 3 proven cases of acne, eczema and psoriasis we analyze Professor Huang Xiangwu’s experience in treating dermatosis on head and face. Professor Huang thoughts that Qianyang Fengsui Dan mainly used for syndromes of deficient yang with upper manifestation and kidney water with deficiency cold .etc, meanwhile during the clinical syndrome differentiation we should pay attention to the distinction between “deficiency fire” and “excess fire”.关键词：dermatosis;deficient yang with upper manifestation;Qianyang Fengsui Dan;clinical experience;Huang Xiangwu
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发布时间：2022-08-31 - 摘要：This paper introduces the experience of Wang Zhongmin in syndrome differentiation and treatment on the female prostate occlusion syndrome. It is stated that qi stagnation and blood stasis is the etiology and pathogenesis of this disease, and the pathogenic factors are kidney-qi deficiency, deficiency of both qi and blood, stagnation of qi due to depression of the liver and the stagnation of pathogenic dampness and heat. The corresponding method of promoting blood circulation and removing blood stasis were used with kidney tonifying, supplementing qi and nourishing blood, soothing the liver, or clearing heat and eliminating dampness.关键词：female prostate occlusion syndrome;promoting blood circulation and removing blood stasis;TCM therapy;experience of famous doctor;Wang Zhongmin
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发布时间：2022-08-31 - 摘要：This paper introduces the clinical experience of Professor Feng Shilun in applying Shenzhuo Decoction. Professor Feng recognizes the decoction from prescription-related syndromes and applies the decoction by identifying prescription-related syndromes. In the process of application, he is not limited to the original decoction but applying to prescription combination and adding drug according to prescription-related syndromes and drug-related syndromes. He often applies the decoction to treat these diseases which cold and dampness evil flow down cause.关键词：Synopsis of Golden Chamber;Shenzhuo Decoction;application of classical prescription;Feng Shilu
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发布时间：2022-08-31 - 摘要：Through analyze three proven cases treated by Yue Fujia, this paper investigates the function of the heart on the male sexual physiology and of the heart-fire on the sexual desire. We summarize the pathogenesis, therapy and prescriptions of the treatment by dealing with the heart in male infertility by Yue Fujia and revealing the practical significance.关键词：male infertility;literature research;Yue Fujia
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发布时间：2022-08-31 - 摘要：This paper aims at summarizing Prescription drug characteristics of Unpublished Ye’s Medical Records written by Ye Tian-shi on treating female disease such as using a variety of drugs, plain but very clever, using the classic prescription, flexible change, pay attention to the foundation of innateness and postnatal, regulating the eight extra-meridians, harmonic qi and blood, be good at applying the Chinses angelica and Fuling, and so on. Summarizing these characteristics will contribute to understand and study Ye’s thoughts about gynecology and to guide clinical practice.关键词：Unpublished Ye’s Medical Records;Ye Tianshi;female disease;prescription drugs
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发布时间：2022-08-31 - 摘要：Objective:To observe the clinical curative effect of the treatment in nonalcoholic fatty liver disease treated with “Jianpi Moji Decoction” combined with western medicine. Methods 60 NAFLD cases were randomly divided into control group and treatment group, 30 cases were in each group. Each case was given Essentiale, meanwhile the treatment group was given “Jianpi Moji Decoction” on the basis treatment, and both treated for 3 months. The changes of liver function, lipids profile, endotoxin and TNF-α, IL-6, IL-8 levels and TCM syndrome integral of two groups before and after treatment were observed. Results: ① Compared before and after treatment in each group, there was significant difference in levels of ALT, GGT and TG in treatment group (P<0.05) and ALT and TG level in the control group (P<0.05). Compared between two groups after treatment, there was significant difference in levels of ALT and TG (P<0.05). ②Compared beteeen the two groups before and after treatment, the endotoxin and TNF alpha, IL-6 and IL 8 level was significantly different in treatment group (P<0.05), and endotoxin was significantly different in the control group (P<0.05); Compared between two groups after treatment, endotoxin and TNF alpha, IL-6 and IL-8 level was significantly different and the treatment group was improved more significant than control group (P<0.05). ③Compared before and after treatment in each group, the score of bilges full, side rib pain, stay, eat less, languid was significantly different in the treatment group (P<0.05). Compare with two groups, and the syndrome was significantly improved in treatment group than that of control group (P<0.05). Conclusion: “Jianpi Moji Decoction” combined with western medicine can significantly relieve the clinical symptoms, improve liver function, reduce the lipid profile level in treating nonalcoholic fatty liver disease, and the mechanism of ‘JianPiMoJi’ “Jianpi Moji Decoction” may be related to reduce the leakage of endotoxin about the bowel “second hit”.关键词：‘JianPiMoJi’ “Jianpi Moji Decoction”;nonalcoholic fatty liver disease;Endotoxin;inflammatory cytokines;second hit
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发布时间：2022-08-31 - 摘要：Objective:To observe the clinical efficacy of “Shuigu Cataplasm” umbilical compressing combined with Tolvaptan in treatment of refractory cirrhosis ascites. Methods 65 cases of patients with refractory cirrhosis ascites were randomized into treatment group (33 cases) and control group (32 cases). The control group was treated with Tolvaptan orally；the treatment group was treated with “Shuigu Cataplasm” umbilical compressing based on the treatment of control group. Two groups were treated for 14 days. The clinical efficacy was observed. The changes of clinical sign (24h urine volume,abdominal girth,body mass),index of correlation tested with color Doppler ultrasound(blood flow volume of portal vein,blood flow volume of splenic vein,depth of ascites dark space),liver function,levels of sodium in blood and urine. Results: ①The total effective rate of the treatment group and control group were 81.82%和62.50% respectively; the difference of clinical efficacy between the two groups was statistically significant(P<0.05). ②Compared before treatment and after follow-up,the difference of 24h urine volume,abdominal girth of the two groups were significant(P<0.05)；after the follow-up,the difference of 24h urine volume,abdominal girth between the two groups were significant(P<0.05). ③Compared before and after the treatment,the difference of blood flow volume of portal vein,blood flow volume of splenic vein and depth of ascites dark space of the two groups were significant(P<0.05)；after the treatment,the difference of blood flow volume of portal vein,blood flow volume of splenic vein and depth of ascites dark space between the two groups were significant(P<0.05). ④Compared before and after the treatment,the difference of liver function index of the treatment group were all significant(P<0.05),while only the difference of GGT, TBIL, ALB, A/G levels of control group were significant(P<0.05). After the treatment,the difference of GGT, TBIL, ALB, A/G levels between the two groups were significant(P<0.05).⑤Compared before and after the treatment,the difference of sodium levels in blood and urine of the two groups were significant(P<0.05)；after the treatment,there was no significant difference in sodium levels of blood and urine between the two groups(P>0.05). Conclusion: “Shuigu Cataplasm” umbilical compressing combined with Tolvaptan in treatment of refractory cirrhosis ascites,can improve the clinical sign,relieve the abdominal water volume of the patients.关键词：liver cirrhosis;refractory ascites;chronic hepatitis B;“Shuigu Cataplasm”;Tolvaptan;umbilical compressing theropy;blood flow volume of portal / splenic vein;depth of ascites dark space
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发布时间：2022-08-31 - 摘要：Objective:To observe the effects of “Buxue Huoxue Decoction” on liver function and hepatic fibrosis in patients with chronic hepatitis B. Methods A total of 186 patients with chronic hepatitis B were randomized into observation group (86 cases) and control group (80 cases). The control group was given diammonium glycyrrhizinate, and the observation group was given “Buxue Huoxue Decotion” based on the control group. After 3-month treatments, the clinical efficacy and the indexes of liver function and hepatic fibrosis were observed before and after treatment. Results: ①The total effective rate was 93.02% in the observation group and 81.25% in the control group, with better efficacy in the observation group than in the control group(P<0.05); ②After treatment, the indexes of liver function were decreased in both groups(P<0.05), with more significant decrease in the observation group than in the control group(P<0.05); ③After treatment, the indexes of hepatic fibrosis were decreased in both groups(P<0.05), with more significant decrease in the observation group than in the control group(P<0.05). Conclusion: “Buxue Huoxue Decoction” is quite effective for chronic hepatitis, and acts to protect liver function and suppress hepatic fibrosis.关键词：chronic hepatitis B;“Buxue Huoxue Decoction”;liver function;hepatic fibrosis
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发布时间：2022-08-31 - 摘要：Objective:To investigate the clinical efficacy of the Wuling San combined with conventional western medicine in the treatment of idiopathic normal-pressure hydrocephalus(INPH). Methods 72 patients with idiopathic normal-pressure hydrocephalus were randomly assigned to the treatment group and the control group equally. Patients in the two groups were treated with conventional western medicine while treatment group received Wuling San and control group with placebo. Both groups treated with 28d and clinical efficacy, Mini Mental State Examination (MMSE) score, the steps to turn around 180° and Evan’s index were observed before and after treatment 2 months later. Results: ① Totally 35 patients in the treatment group and 34 patients in the control group completed the trial. ② At 2 months after treatment,the total clinic effective rate was 77.14% in the treatment group, with statistical difference when compared with the control group which was 55.88% were improved (P<0. 05). ③ Levels of MMSE score which increased in the two groups after treatment (P<0.05) was obviously higher in the treatment group than in the control group (P<0. 05). ④ The steps to turn around 180° and the Evan’s index were obviously less after treatment in the two groups (P<0.05), and it was also had a significant difference between the treatment group and the control group at 2 month after treatment, the treatment group used less steps (P<0. 05). ⑤ There was no significant difference in the incidence of adverse reactions between the two groups (P>0. 05). Conclusion: The Wuling San in treating INPH patients was superior to the effect of using common treatment alone. It also could improve patients living abilities.
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发布时间：2022-08-31 - 摘要：Objective:To study the influence of “Buqi Huoxue Tongluo Decoction” on the nailfold microcirculation and nerve function in patients with post-stroke hemiplegia. Methods:Fifty-six subjects were randomized into two groups:control group in which 28 cases were treated by conventional therapy and observation group in which 28 cases were treated by conventional therapy and “Buqi Huoxue Tongluo Decoction”. The nailfold microcirculation and serum nerve function indexes were observed before and after treatment. Results: After treatment, the white microembolus rate and vascular malformation rate were reduced and the apical vascular diameter was increased in both groups(P<0.05), with significant differences between the two groups(P<0.05). After treatment, the serum NSE, S100B and GFAP were reduced in both groups(P<0.05), with significant reduction in the the observation group than in the control group(P<0.05). Conclusion::“Buqi Huoxue Tongluo Decoction” is effective to improve the microcirculation and nerve function in the treatment of post-stroke hemiplegia.
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发布时间：2022-08-31 - 摘要：Objective:To observe the clinical efficacy on patient with acute facial paralysis with “Qianzheng San” (QZS) and warm acupuncture at Zusanli(ST36). MethodsSixty cases with acute idiopathic facial palsy were randomly divided into treatment group and control group, 30 cases in each group. The control group treated with normal western medicine and the treatment group was treated with QZS and warm acupuncture of Zusanli on the basis of normal treatment. The treatment was 14d for both groups, and the number of EPCs from peripheral blood and number of proliferative colonies of EPCs were measured and comparison was made between two groups. Results: ①The marked effective rate was 86.67% for treatment group and 60.00% for control group, and the difference was significant (P<0.05).② Compared in each group before and after treatment, the number of EPCs and the number of proliferative colonies of EPCs of two groups both were increased, and the difference was statistically significant (P<0.05). Compared between groups after treatment, there was significant difference in the number of EPCs and the number of proliferative colonies of EPCs (P<0.05). Conclusion: There was significant curative effect on patient with acute facial paralysis with QZS and Warm Acupuncture Zusanli, and the mechanism may be related to promote vascular endothelial injury repair.关键词：acute idiopathic facial palsy;facial paralysis;“Qianzheng San”;warm acupuncture;Zusanli(ST36);vascular endothelial injury
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发布时间：2022-08-31 - 摘要：Objective:To observe the clinical efficacy of cervical vapor-deposited prescription in treating cervical spondylotic neck type and radiculopathy. Methods Two hundred patients of neck type and radiculopathy of cervical spondylosis were randomized into treatment group and control group,100 cases in each group. The treatment group was treaded with cervical vapor-deposited prescription,and control group were treated with a finger and rolling of manipulation to release and adjust the neck muscles. Two groups were both treated for 3 treatments. Clinical curative efficacy was observed,and the VAS, the neck disability index and the symptoms of cervical spondylosis rating scale changes was measured and compared. Results: ①The total effective rate of the treatment group and the control group were 87.0% and 76.0%. The comparison of clinical efficacy differences between groups was statistically significant(P<0.05). ②Compared before and after the treatment,the difference of the VAS, the neck disability index and the symptoms of cervical spondylosis rating scale in each group and between the two groups was statistically significant(P<0.05). Conclusion: The effect of the cervical vapor-deposited prescription treatment of cervical spondylotic neck type and radiculopathy was satisfacty,this method can relieve pain obvious,improve the quality of the patient’s life.关键词：cervical spondylosis;cervical vapor-deposited prescription;dry powder fomentation
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发布时间：2022-08-31 - 摘要：Objective:To observe the clinical effects on cervical HPV infection with Jiawei Jianpi Decoction combined with XinFuNing. Methods60 cases of patients with cervical HPV infection were randomly divided into treating group(treated with Jiawei Jianpi Decoction plus XinFuNing) and control group(treated with XinFuNing only), 30 cases in each group. The treatment period of each group is 3 months, in which observing the clinical efficacy, HPV turning rate and the review of TCM syndrome. Results:①The total effective rate of the treating group(86.67%) is higher than the control group(43.33%)(P<0.05). ②The turning rate of cervical HPV of the treating group(80%) is higher than the control group(40%)(P<0.05). ③The score of the treating group is significantly reduced on the capacity of leucorrhea , the peculiar smell of leucorrhea , the yellow color of leucorrhea and the total score(P<0.05),and at the same time there is no obvious difference in each score of the control group. Compared between groups after treatment, the scores on the capacity of leucorrhea , the peculiar smell of leucorrhea , the yellow color of leucorrhea and the total score of the treating group were lower than the control group(P<0.05). Conclusion:The effects of Jiawei Jianpi Decoction combined with XinFuNing used in treating cervical HPV infection is significantly more effective on enhancing the turning rate of HPV and improving TCM syndrome than the effects of using XinFuNing only.
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发布时间：2022-08-31 - 摘要：Objective:To observe the clinical efficacy of “Zhixuean Mixture” in the treatment of acute hemorrhoids bleeding. MethodsSixty subjects were randomized into treatment group and control group(30 cases in each group), and respectively treated with “Zhixuean Mixture” and “Zhining Pills” for seven days. The clinical efficacy, and the scores of such symptoms as hematochezia, pain, prolapse, hemorrhoids mucosa state and hemorrhoidal size were observed before and after treatment. Results:The total effective rate was 93.33% in the treatment group and 83.33% in the control group, with better effects in the treatment group than in the control group(P<0.05). After treatment, the scores of hematochezia, pain, hemorrhoids mucosa state and hemorrhoidal size were reduced in both groups(P<0.05,P<0.01), with more significant reduction in the treatment group than in the control group(P<0.05). Conclusion:“Zhixuean Mixture”is quite effective in the treatment of acute hemorrhoids bleeding.关键词：“Zhixuean Mixture”;hemorrhoids;bleeding
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发布时间：2022-08-31 - 摘要：This paper discusses the connotation and origin of Xinkai Kujiang therapeutic method and analyzes the clinical experience of inmammary cancer after operation. It is considered that Xinkai Kujiang therapeutic method can regulate cold and heat and mediate qi activity. In clinical practice, Ku and Xin were used as compatibility and assisted with Gan Medicine.关键词：breast cancer after surgery;Xinkai Kujiang;treatment experience
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发布时间：2022-08-31 - 摘要：This paper analyzes the heat-clearing function of Lophatherum gracile, including dispersing wing heat to treat exogenous condition, clearing heat heat to remove vexation, clearing small intestine heat to treat stranguria, and its pharmacological functions as well.关键词：Lophatherum gracile;heat-clearing function;herbal property analysis
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发布时间：2022-08-31 - 摘要：Objective:To explore the effects and possible mechanism of JianPi JieDu Recipe (JPJD) on metastasis of colorectal cancer. Methods The effect of JPJD on the proliferation of colorectal cancer LoVo cells was tested by CCK-8 assay. Using JPJD, over-expression of COX-2 Gene and/or GSK-3β selective inhibitor SB-216763 in LoVo cells for 24h, the migration of LoVo cells was analyzed by Transwell assay; the expression of COX-2 and β-catenin protein was detected by western blot; MMP-7 expression in cell culture supernatant was assayed by ELISA. Results: JPJD alcohol extracts had obvious inhibition on the proliferation of LoVo cells in dose and time-dependent manner. JPJD could down-regulate the migratory ability of LoVo cells compared with the control group (P<0.01). JPJD could down-regulated the expression of COX-2, reduced the accumulation of β-catenin in the nuclear of LoVo cells, following by the decrease of the β-catenin targeted MMP-7 expression (P<0.01). COX-2 could increase the accumulation of β-catenin in the nuclear and promote the expression of β-catenin targeted MMP-7, leading to increased metastatic potential of LoVo cells (P<0.01). We further showed that an increase of COX-2 expression offset the repressive activity of JPJD on β-catenin and MMP-7 expression; activating of β-catenin signal pathway rescued LoVo cells from suppressed migration by JPJD. Conclusion: JianPi JieDu Recipe inhibited CRC metastasis may via down-regulation of COX-2/β-catenin/MMP-7 signaling pathway.关键词：JianPi JieDu Recipe;colorectal cancer;COX-2;β-catenin;MMP-7;In vitro
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发布时间：2022-08-31 - 摘要：Objective:To investigate the effects of modified “Simiao Decoction” on renal function, lipid metabolism, urine biochemistry and renal pathology in rats of uric acid nephropathy. Methods Uric acid nephropathy rats were made with Yeast and Adenine, and then randomized into normal group(ZC group), model group(MX group), allopurinol group(XY group) and treatment group(SMF group), and respectively treated with according therapies. The renal function(BUN, Scr, UA), lipids(TC, TG, HDL, LDL), urine biochemistry(NAG, β2-MG, 24-hour urine protein) and renal pathological changes were observed. Results: ①Compared with ZC group, the levels of BUN, Scr, UA, TC, TG, HDL, LDL, NAG, β2-MG and 24-hour urine protein were significantly higher in MX group(P<0.01). ②Compared with MX group, the levels of BUN, Scr, TC, LDL, NAG, β2-MG and 24-hour urine protein were significantly lower in SMF group(P<0.01); the level of UA was significantly reduced in XY group(P<0.01); while the levels of Scr, TC, TG and HDL was of no significance in XY group(P>0.05). ③Renal pathological changes showed that renal tubular urate crystals, inflammatory cell infiltration and tubular interstitial injury were less in SMF group and MX group, with strikingly less lesion in the SMF group than in the MX group(P<0.05). Conclusion:s Modified “Simiao Decoction” can improve renal function, lipid metabolism, urine biochemistry and renal pathology in rats of uric acid nephropathy.关键词：uric acid nephropathy;hyperuricemia;chronic kidney disease;modified “Simiao Decoction”;rat
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发布时间：2022-08-31 - 摘要：Objective:To investigate the mechanism of tyrosine kinase c-kit protein expression and serum stem cell factor(SCF) in producing abdominal fullness by chemotherapy in rats and its role in treating fullness by “Xiaopi Decoction”. Methods Sixty Wistar rats were divided into normal group, model group, Cisapride group, and high-dose, medium-dose and low-dose “Xiaopi Decoction” groups. Except for the normal group, the rats in the other five groups were established to be spleen deficiency by injection of chemotherapy drugs by tail vein. The rats in the normal group and model group were given physiological saline by gavage; the rats in the low-dose, medium-dose and high-dose groups were given 100%, 150% and 200% of “Xiaopi Decoction”; and the rats in the Cisapride group given Cisapride by intragastric gavage. The treatment was given for 7 days. The general condition of the rats were observed, the enzyme-linked immunosorbent assay(ELISA) was adopted to detect serum SCF and the immunohistochemical detection was used to determine the c-kit protein expression in the gastric muscles. Results: The c-kit protein expression in the gastric muscle and serum SCF level were lower in the model group than in the normal group(P<0.05); the c-kit protein expression in the gastric muscle and serum SCF level were higher in the high-dose “Xiaopi Decoction” group than in the model group and Cisapride group(P<0.05); the c-kit protein expression in the gastric muscle and serum SCF level were changed little in medium-dose and low-dose “Xiaopi Decoction” groups(P>0.05). Conclusion: “Xiaopi Decoction” can increase the c-kit protein expression in the gastric muscle and serum SCF level to maintain the stability of c-kit/SCF signaling pathway, hence to restore gastrointestinal movement to relieve abdominal fullness after chemotherapy.关键词：“Xiaopi Decoction”;chemotherapy;abdominal fullness;c-kit protein;stem cell factor(SCF)
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发布时间：2022-08-31 - 摘要：Objective:To investigate the protective effects and possible mechanisms of new Wenshen Shengjing Decoction(new WSSJD) on cyclosporine-induced oxidative stress to epididymal tissue and sperm in mice. Methods Eight-week-old male Kunming mice were randomly assigned into normal control group, solvent group, model group, western medicine group and Chinese medicine group, 15 mice in each group. Mice in normal control group received intraperitoneally normal saline, and mice in western medicine group, Chinese medicine group and model group were injected intraperitoneally with cyclosporine(15 μg·g-1·d-1) for 30 days; meanwhile, mice in western medicine group and Chinese medicine group were respectively gavaged with clomifene citrate and new WSSJD for 30 days consecutively. The body weight and epididymal weight were recorded; the contents of malondialdehyde(MDA) and glutathione(GSH) and activity of glutathione peroxidase(GSH-Px) in epididymal tissue were detected; the ROS level, apoptosis and death of sperms in mice epididymis were examined by flow cytometry assay. Results: Compared with the normal control group, all indexes above changed insignificantly in the solvent group(P>0.05); the body weight increased, epididymal index reduced, the GSH level and GSH-Px activity decreased, MDA level increased, the ROS level in mature sperms increased, the survival rate of sperms reduced and its death rate increased, all with significant differenced(P<0.05). Compared with the model group, in the western medicine group, the body weight and epididymal index increased, the content of GSH and activity of GSH-Px increased, the levels of MDA and ROS decreased, and the survival rate of sperms significantly increased while the death rate of sperms reduced, all with striking differences(P<0.05). Compared with the western medicine group, in the Chinese medicine group, the body weight increased, the MDA content in epididymal tissue and ROS level in mature sperms significantly decreased, and the survival rate of sperms increased, all with significant differences(P<0.05). Conclusion: New WSSJD can significantly relieve the oxidative injury in epididymis induced by cyclosporine and enhance the survival rate of mature sperms.关键词：new Wenshen Shengjing Decoction;cyclosporine A;epididymis;oxidative damage;sperm;apoptosis
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发布时间：2022-08-31 - 摘要：Objective:To study the effects of the polysaccharide from the pseudobulbs of Oreorchis patens on immunocompromised mice. Methods Immunocompromised mice was made by intraperitoneal injection of cyclophosphamide. The mice were divided into control group, model group, positive group, and high-dose, medium-dose, low-dose Oreorchis polysaccharide groups(270 μg/g, 135 μg/g, 67.5 μg/g) and were respectively treated with the according methods. Then the spleen index, thymus index, delayed-type hypersensitivity(DTH), serum hemolysin and phagocytic coefficient were measured. Results: There were striking differences in the immunologic indexes between the control group and model group(P<0.05). Compared with the model group, the spleen indexes increased in positive group, and high-dose, medium-dose, low-dose Oreorchis polysaccharide groups; medium-dose Oreorchis polysaccharide group had some effects on delayed-type hypersensitivity(P<0.01); high-dose Oreorchis polysaccharide group had some impacts on all immunologic indexes(P<0.01). Conclusion: High-dose Oreorchis polysaccharide can boost immunity in immunocompromised mice.关键词：Oreorchis patens;polysaccharide;immunologic competence
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发布时间：2022-08-31 - 摘要：Objective:To optimize the extraction techniques of compound Shi-Lin-Tong capsule and compare it with its original extraction technique. Methods The orthogonal test was used by two evaluating methods (the first method was to determine the contents of chlorogenic acid and schaftoside and the extraction rate; the second method was to determine the HPLC characteristic fingerprint peak area and extraction rate) to investigate the influence of three factors on extraction factors(solvent doses, extraction time and alcohol concentration; and the single factor test was used to investigate the effect of extraction frequency on the transfer rate of active ingredients. The analytic hierarchy technique was used to determine weight coefficients of each index and to evaluate the results of the test. The transfer rates of chlorogenic acid and schaftoside as well as the difference of two extraction techniques were compared. Results: The outcomes obtained from the two evaluating methods were consistent. The optimized extraction technique of Shi-Lin-Tong capsule was as follows:the medicinal materials were extracted with ten times of water at the first extraction and six times of water at the second extraction, one hour for each time; and the concentrated solution was added to anhydrous ethanol until the ethanol concentration reaching 80% for ethanol precipitation. The transfer rates of chlorogenic acid and schaftoside of the optimized extraction technique was significantly higher than the original extraction technique. Conclusion: The optimized extraction technique is feasible, stable, and repeatable, and facilitates to extract the effective components of compound Shi-Lin-Tong capsule and suits for industrial production.关键词：compound Shi-Lin-Tong capsule;orthogonal experiment;analytic hierarchy process;multiple index;fingerprint;extraction technique
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发布时间：2022-08-31 - 摘要：This paper summarizes Velvet antler polypeptides extraction technology and its pharmacological action. Velvet antler polypeptides extraction technology include extraction method, enzymatic hydrolysis, ultrasonic method and high voltage electric field method. The purification methods of Velvet antler polypeptides include salting-out, ultra filtration method, ion exchange method and electrophoresis. The pilose antler peptide plays an important pharmacological effects in the immune system,circulatory system,nervous system,bone metabolism and glucose metabolism. The pilose antler peptide also has effect of anti-inflammatory,anti-virus, oxidation resistance, fatigue resistance,and so on.关键词：velvet antler polypeptides;chemical composition;extraction process;pharmacological effects
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发布时间：2022-08-31 - 摘要：This paper summarizes the therapeutical effect of traditional Chinese medicine from oxidative stress mechanism on Alzheimer’s disease in recent years. Through testing markers of oxidative stress, study brain energy metabolism related ATPas and related signal pathway, this paper confirms the significant effect of the traditional Chinese medicine and puts forward the direction of the multiple treatment for future research.关键词：Alzheimer’s disease (AD);traditional Chinese medicine;Antioxidation
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发布时间：2022-08-31
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