最新刊期
期 7 ， 2015
- 摘要：Objective:To observe the clinical efficacy of modified “Shengjiang Powder” in the treatment of pulmonary infection combined with sepsis of toxin-heat excess Methods:Fifty subjects were randomized into two groups:control group in which 25 cases were treated with routine modality and treatment group in which 25 cases were treated with routine modality and modified “Shengjiang Powder”, with a course of 7 days. The symptom scores, APACHEⅡ score, CRP, TNF-α and IL-6 were evaluated before and after treatment Results:After treatment, the symptom scores were reduced in both groups(P<0.05), with lower score in the treatment group than in the control group(P<0.05); the APACHEⅡ scores and the levels of CRP, TNF-α and IL-6 were decreased in both groups(P<0.05), with more significant decrease in the treatment group than in the control group(P<0.05) Conclusion:Modified “Shengjiang Powder” is effective for pulmonary infection combined with sepsis of toxin-heat excess by reduce the levels of inflammatory cytokines to depress inflammation.关键词：sepsis;pulmonary infection;modified “Shengjiang Powder”;inflammatory cytokine
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发布时间：2022-08-31 - 摘要：Objective:To observe the clinical efficacy of herbal administration and eight-section brocade in the treatment of chronic obstructive pulmonary disease(COPD) of stable stage Methods:Seventy-three subjects were randomized into control group and treatment group; all the cases were treated by routine modality, and the treatment group was additionally given herbal administration for three months and sight-section brocade for one year. The lung functions and 6-minute walking test were done before and after treatment Results:After treatment, the levels of FEV1 and FEV1% were increased(P<0.05), with higher levels in the treatment group than in the control group(P<0.05); after treatment, the distances of six-minute walk test were increased(P<0.05), with longer distance in the treatment group than in the control group(P<0.05) Conclusion:Herbal administration and eight-section brocade in combination can improve the lung functions in COPD of stable stage.关键词：chronic obstructive pulmonary disease;stable stage;eight-section brocade;lung function
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发布时间：2022-08-31 - 摘要：Objective:To observe the clinical efficacy of combined “Zicui Juanbi Decoction” and transcutaneous acupoint electro-stimulation(TAES) in the treatment of diabetic peripheral neuropathy(DPN) Methods:One hundred and thirty two cases of DPN were randomized into four groups(mecobalamine group, TAES group, herbal group and combined group, 33 cases in each group), and treated by respectiv Methods: for one month. The clinical efficacy, Toronto clinical system scores(TCSS), blood glucose, ankle-brachial blood pressure index(ABI) and velocity of dorsal pedal artery were observed before and after treatment Results:①The clinical effective rate was 48.5%, 74.2%, 78.1% and 90.6% respectively in mecobalamine group, TAES group, herbal group and combined group, with higher rates in the latter three groups than in the former group(P<0.01). ②After treatment, the TCSS were significantly lowered in the TAES group, herbal group and combined group(P<0.01); the TCSS was lower in the TAES group, herbal group and combined group than in the mecobalamine group(P<0.05, P<0.01), and with lower TCSS in the combined group than in the TAES group and herbal group(P<0.05). ③After treatment, the levels of blood glucose(FPG, 2hPG) were reduced in the TAES group, herbal group and combined group(P<0.05, P<0.01), with lower level in the combined group than in the mecobalamine group(P<0.01). ④After treatment, the velocity of dorsal pedal artery in the combined group, herbal group and combined group was increased(P<0.01), with higher velocity in these three groups than in the tomecobalamine group(P<0.05, P<0.01) Conclusion:Combined “Zicui Juanbi Decoction” and transcutaneous acupoint electro-stimulation(TAES) is quite effective against diabetic peripheral neuropathy in relieving clinical symptoms and peripheral hemodynamics.关键词：“Zicui Juanbi Decoction”;transcutaneous acupoint electro-stimulation;type 2 diabetes;peripheral neuropathy
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发布时间：2022-08-31 -
Clinical observation of combination therapy with medicine bar percussion for hemiplegia after stroke
摘要：Objective:To observe the clinical efficacy of combination therapy with medicine bar percussion for hemiplegia after stroke Methods:200 subjects were randomly divided into treatment group and control group. 100 cases in the treatment group were treated by combination therapy with medicine bar percussion and 100 cases in control group were only treated by Acupuncture. The clinical course of each group was 21 days. The rating scale, the NIHSS scale, index and classification of Barthel were observed Results:① Before and after the treatment, there was statistic significance in the difference of the rating scale, the NIHSS scale, index and classification of Barthel in each group (P<0.05). After the treatment, there was statistic significance in the difference of the rating scale, the NIHSS scale, index and classification of Barthel between the two groups (P<0.05) ② Compared after the treatment, there was statistic significance in the difference of index and classification of Barthel (P<0.05) Conclusion:Combination therapy with medicine bar percussion for hemiplegia after stroke can promote phantom limb functional recovery, eliminate syndrome of swelling and numbness, and improve neurological function.- 8
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发布时间：2022-08-31 - 摘要：Objective:To observe clinical effect of “Yiqi Huayu Decoction” in the treatment of qi deficiency and blood stasis type of uterine leiomyoma Methods:60 cases of uterine fibroids were randomly divided into treatment group and control group, 30 cases in each group. The treatment group received “Yiqi Huayu Decoction”, control group were treated with Guizhi Fuling capsule. Two groups were treated for 3 menstrual cycles, observing the size of uterine leiomyoma, menstruation (menstrual period and menstrual volume), TCM syndrome score and female hormone (FSH, LH, E2) levels Results:①Compared before and after treatment within group, the two groups were statistically significant differences in the size of uterine leiomyoma (P<0.05); between the groups after treatment, and there has no statistically significant difference between the volume of uterine leiomyoma(P>0.05).②Between the groups after treatment, the efficacy of the treatment group significantly better than the control group in shorten the menstrual period and reduce menstruation(P<0.05). ③Compared before and after treatment within group,the two groups were statistically significant difference between the TCM syndrome score (P<0.05); between the groups after treatment, there was statistical significance of TCM syndrome score (P<0.05). ④Comparison of before and after treatment within group, the two groups had no statistically significant differences in the level of FSH, LH and E2 (P>0.05); between the groups after treatment comparison,no statistically significant differences in the level of FSH, LH and E2 (P>0.05) Conclusion:“Yiqi Huayu Decoction” treating qi deficiency and blood stasis type of uterine leiomyoma, can reduce the tumor volume, improve menstrual disorders, relieve the clinical symptoms of patients.关键词：uterine leiomyoma;qi deficiency and blood stasis;“Yiqi Huayu Decoction”;Guizhifuling capsule;volume of uterine leiomyoma
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发布时间：2022-08-31 - 摘要：Objective:To evaluate the efficacy of the traditional Chinese medicine “Wubai Decoction” combined with fluconazole on oral candidiasis Methods:105 cases of oral candidiasis patients were randomly divided into group A (“Wubai Decoction” mouth rinse group) and B (0.9% sodium chloride mouth rinse combined with fluconazole) and C (“Wubai Decoction” mouth rinse combined with fluconazole), 35 cases in each group. Clinical curative effect, drug safety and the negative rate of Candida albicans were evaluated in all 14 days Results:①Finally 94 cases were completed, among which 35 cases in group A, 32 cases in B group and 27 cases in group C. ②Total effective rate of the treatment of group A , B and C were 68.57%, 50.00% and 85.19% respectively. Clinical curative effect comparison between groups, group C was better than group A and B (P<0.05). ③The negative rate of Candida albicans in group A, B and C were 40.00%, 40.63% and 66.67% respectively, and group C was the best in 3 groups (P<0.05). ④Adverse drug reactions were not found in 3 groups Conclusion:“Wubai Decoction” mouth rinse combined with fluconazole for oral candidiasis can achieve satisfactor Results:.关键词：oral candidiasis;“Wubai Decoction”;fluconazole;fungal infection;integrated traditional Chinese and Western medicine therapy
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发布时间：2022-08-31 - 摘要：Objective:To observe the clinical efficacy of Jiawei arthromyodynia “San Liang San Decoction” combined with methotrexate in treatment of cold dampness and blood stasis rheumatoid arthritis Methods:120 cases of patients with cold dampness and blood stasis rheumatoid arthritis were randomly divided into treatment group (80 cases) and control group (40 cases). The control group was treated with methotrexate orally; the treatment group was treated with Jiawei arthromyodynia “San Liang San Decoction” based on the treatment of the control group. Two groups were treated for 8 weeks. The clinical efficacy and safety were observed. The changes of linical symptoms and signs (TJC28, SJC28, VAS score), laboratory indexes (ESR, CRP), the condition assessment index (PGA, MDGA, CDAI) were compared Results:①The total efficiency of the treatment group and the control group were 86.25% and 67.50% respectively. The difference of the clinical efficacy between the two groups was statistically significant (P<0.05). ② Compared before and after the treatment, the difference of TJC28, SJC28, VAS score of the two groups were statistically significant (P<0.05); after the treatment, the difference of TJC28, SJC28, VAS score between the two groups were statistically significant (P<0.05). ③Compared before and after the treatment, the differences of the levels of ESR, CRP of the two groups were statistically significant (P<0.05); the difference of HGB level in the treatment group was statistically significant (P<0.05), while had no statistically significant difference in HGB level in the control group (P>0.05). After the treatment, there was no statistically significant differences in ESR and CRP level (P>0.05) while the difference of HGB level was statistically significant (P<0.05). ④ Compared before and after the treatment, the difference of PGA, MDGA, CDAI index level were statistically significant (P<0.05); after the treatment, the difference of PGA, MDGA, CDAI index level was statistical significance (P<0.05). ⑤ The occurrence rate of adverse reactions of the two groups were compared, the difference was statistically significant (P<0.05) Conclusion:Jiawei arthromyodynia “San Liang San Decoction” combined with methotrexate in treatment of cold dampness and blood stasis rheumatoid arthritis can relieve pain, reduce the disease activity, and has less adverse reactions.关键词：rheumatoid arthritis;cold dampness and blood stasis;Jiawei arthromyodynia “San Liang San Decoction”;methotrexate;regulating blood method
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发布时间：2022-08-31 - 摘要：Objective:To observe the clinical effect of Renying modified acupuncture treatment of vertebral artery type cervical spondylosis Methods:Eighty patients of Vertebral artery type of cervical spondylosis were randomized into treatment group and control group,40 cases in each group. The treatment group was treated with modified Renying point acupuncture treatment,and control group were treated with conventional acupuncture on Renying point. Two groups were both treated for 14 days. Clinical curative efficacy was observed, and the plasma neuropeptide Y (NPY) and the level of cervical spondylosis of vertebral artery type function assessment scale (FS-CSA) changes was measured and compared Results:① The total effective rate of the treatment group and the control group were 97.50% and 55.00%. The comparison of clinical efficacy differences between groups was statistically significant (P<0.05). ② Compared before and after the treatment, the difference of plasma neuropeptide Y levels in each group and between the two groups was statistically significant (P<0.05). ③ By comparing within groups before and after the treatment, the difference in FS-CSA scores was statistically significant (P<0.05). After treatment,FS-CSA score difference between the two groups was statistically significant (P<0.05) Conclusion:The effect of Renying modified acupuncture treatment of vertebral artery type cervical spondylosis was satisfacty, this method can also improve the vertebral artery insufficiency.关键词：cervical spondylosis;vertebral artery;vertigo;Renying point;modified acupuncture;neuropeptide Y;sympathetic nerve
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发布时间：2022-08-31 - 摘要：This paper introduces Professor Wang Lingtai’s experience with ascites cirrhosis after hepatitis. It is believed that its key pathogenesis is infection of epidemic factors and spleen-kidney dysfunction, spleen-kidney-yang deficiency in the early and moderate stages, and liver-kidney-yin deficiency in the later stage. The therapeuti Methods: are principally to warm or tonify kidney and strengthen spleen, and supplemented by activating blood and disinhibiting water; integrative Chinese and Western medicine, and combined internal and external treatments should be prescribed. One proven case was presented.关键词：ascites cirrhosis;hepatitis;famous doctor’s experience;Wang Ling-tai
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发布时间：2022-08-31 - 摘要：The logical and realistic possibility of integrated traditional Chinese and western medicine was analyzed by philosophical principles. It is view that the fundamental reason for different theory system is due to differences in the standard and way of division of the world. A theoretical system formally accepted is usually marked by establishment of its own ontology language system. This paper adopted the intuitive concept of set to interpret the logical possibility of integrated traditional Chinese and western medicine, and found that it is realistically impossible to produce the ontology language system belonging to integrated traditional Chinese and western medicine. The identity of integrated traditional Chinese and western medicine at last depends on what kind of standard of measure we used. Based on the above theoretical review,we also analyzed the major factors influencing the future development of traditional Chinese medicine,integrated traditional Chinese and western medicine.关键词：integrated traditional Chinese and western medicine;ontology;language
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发布时间：2022-08-31 - 摘要：This paper aims to discuss the research approach of mechanisms about traditional Chinese herbal patches for knee osteoarthritis. It is viewed that attention should be paid to explore the analgesia and anti-inflammatory efficacy mechanism of traditional Chinese herbal patches. We propose that the principle of traditional Chinese herbal patches delay cartilage degeneration should be clarified and the study of effects and safety of immune and neurochemistry system should be strengthen.关键词：knee osteoarthritis;traditional Chinese herbal patch;efficacy mechanism;safety
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发布时间：2022-08-31 - 摘要：Objective:To establish an evaluation method of efficacy on monitoring pulsatile perfusion during cardiopulmonary bypass (CPB)based on “Cunkou” sphygmogram test through monitoring effects of different types of pulsatile perfusion on body during cardiopulmonary bypass Methods:52 patients with heart valve diseases undergoing cardiopulmonary bypass were randomized into pulsatile group(P group,n=26) and nonpulsatile group(NP group,n=26). The “Cunkou” pulse wave,pump flow rate,arterial pressure and pump pressure were recorded by PowerLab 8/30 physiology recorder. The value of pulse pressure(ΔP),mean arterial pressure(MAP),energy equivalent pressure(EEP) and surplus hemodynamic energy(SHE) were calculated during CPB stabled. Thrombelastograph analyzer(TEG)was examined Results:① The “Cunkou” pulse waveforms could be detected in all patients before CPB. After the CPB, the “Cunkou”pulse waveforms could be detected in P group but could not be detected in NP group. ② The ΔP,EEP and SHE were significantly higher in P group than NP group(P<0.001),and the MAP was no significant difference in both groups(P>0.05). ③ The R level amplified longer in P group than NP group(P<0.05)and CI level cut shorter in TEG in P group than in NP group(P<0.05) Conclusion:Pulsatile perfusion during cardiopulmonary bypass was better than nonpulsatile in such aspects as increasing blood perfusion pressure, increasing blood perfusion energy and decreasing blood viscosity, etc. The ΔP,EEP and SHE were significantly higher in pulsatile perfusion during cardiopulmonary bypass than nonpulsatile. It suggested that sphygmogram can be used as an Objective: index on monitoring pulsatile perfusion during cardiopulmonary bypass.关键词：cardiopulmonary bypass;pulsatile perfusion;“Cunkou” sphygmogram;pulse pressure;energy equivalent pressure;surplus hemodynamic energy
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发布时间：2022-08-31 - 关键词：ulcerative colitis;dysentery;teaching ward round
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发布时间：2022-08-31 - 摘要：This paper introduces 2 proven cases of Professor Yan Shiyun’s clinical experience in differentiating and treating difficult and complicated cases. In this paper, we summarize Professor Yan’s clinical characteristics in differentiating and treating difficult and complicated cases, and those characteristics can be summarized as cold and warmin Methods: used together, combination of benefiting and attacking, regulating five organs together and treating yin, yang, qi and blood together.关键词：SAPHO syndrome;syringomyelia;TCM therapy;famous doctors’ experience;Yan Shi-yun
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发布时间：2022-08-31 - 摘要：This paper is to introduce Professor He Liren’s experience in differentiating and treating hypertension. It is viewed that hypertension can be cured through such therapies as regulating liver, nourishing kidney, regulating lung, strengthening spleen, calming heart, dispelling turbidity and dredging collaterals, etc. A proven case is presented.关键词：hypertension;regulating five organs;eliminating obstruction;famous doctor’s experience;He Li-ren
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发布时间：2022-08-31 - 摘要：This paper introduces the experience of Professor Fang Bangjiang in treating exogenous febrile disease. Based on three dimensional dialectical thoughts, Professor Fang emphasizes that it is important to pay attention to expel the wind pathogenic factor, relieve exterior-interior syndrome, release the diaphragm, nourish Yin to produce the body fluid and protect stomach qi when syndrome differentiation. He is good at innovative application of insect drugs.关键词：exogenous febrile disease;clinical experience;Fang Bangjiang
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发布时间：2022-08-31 - 关键词：gynecological disease;“Wenjin Decoction”;Treatise on Febrile Diseases;clinical application
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发布时间：2022-08-31 - 摘要：This paper investigates the development of syndrome differentiation and treatment of febrile diseases though analysis syndrome differentiation and treatment of febrile diseases and pestilence, text structure of Treatise on Febrile Diseases and Treatise on Pestilence, the clinical practice that Zhang Zhongjing and Wu Youke lived by and modern science’s understanding on blood heat and plague.关键词：Febrile Diseases;pestilence;combination of cold and heat
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发布时间：2022-08-31 - 关键词：lumbar intervertebral disc herniation;Chinese medicine;conservative therapy
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发布时间：2022-08-31 - 摘要：Objective:To investigate the clinical efficacy of improved suture-fixation operation in treatment of grade III hemorrhoids Methods:100 cases were randomly divided into treatment group (suture-fixation operation, 50 cases) and control group (Milligan-Morgan hemorrhoidectomy, 50 cases). The clinical efficacy, recurrence rate, VAS score, anal function and the satisfaction of patients were observed between the two groups Results:① Total effective rate in the two groups were 100%, there was no statistic significance in clinical efficacy between the two groups(P>0.05) ② In the comparison after the operation, there was statistic significance in VAS score and hospitalization time between the two groups(P<0.05). ③In the comparison after the operation, there was statistic significance in secondary blooding between the two groups (P<0.05). ④In the comparison after the operation, there was no statistic significance in anal function score between the two groups (P>0.05). ⑤In the comparison during the time 2 years after the operation, there was no statistic significance in recurrence rate between the two groups (P>0.05). ⑥In the comparison 2 years after the operation, there was statistic significance in patient satisfaction between the two groups(P<0.05) Conclusion:The improved suture-fixation operation in treatment of grade III hemorrhoids is valid in reducing secondary bleeding and pain, shortening hospitalization time, with relatively high satisfaction in the middle age follow-up.关键词：hemorrhoids;grade Ⅲ;suture-fixation operation;improved operation;secondary bleeding;pain;patient satisfaction
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发布时间：2022-08-31 - 摘要：Objective:To observe the effect on the content of monoamine neurotransmitter and ATP enzyme by needling “Top siguan” in cerebral ischemia reperfusion rabbit,and to discuss the mechanism of nerve cells protection Methods:rabbits were randomly divided into three groups :sham-operated group, model group and acupuncture group,and each group was divided into post-ischemia 1d,3d and 7d different periods subgroups. The focal cerebral ischemia and reperfusion model were established by the method of the middle cerebral artery occlusion(MCAO). They were performed by ischemia 2 h and then used for reperfusion. After 6 h,acupuncture group was accepted treatment by electroacupuncture “top Siguan”,once a day. The rabbits in the three groups were respectively executed and got cerebral tissue in 1 d,3 d and 7 d. Then they were determined the level of dopamine (DA),noradrenaline (NE) and 5-hydroxytryptamin (5-HT) by using fluorospectrophotometry,and detected the content of Na+-K+-ATP and Ca2+-ATP by using colorimetry Results: Compared by sham-operated group in the same time,DA,NE and 5-HT were decreased obviously in model group especially in the 1 d group,but DA,NE and 5-HT somewhat increased with cerebral ischemia reperfusion time gone by. Na+-K+-ATP and Ca2+-ATP decreased obviously, the differences was statically significant (P<0.01). Compared with the model group in every time, the level of DA,NE and 5-HT, the content of Na+-K+-ATP and Ca2+-ATP were increased in different degree(P<0.01) Conclusion:Acupuncture “Top siguan”can improve ATP enzyme metabolism,can reduce monoamine neurotransmitter release and inhibit monoamine neurotransmitter toxicity effect in cerebral ischemia reperfusion rabbit. so needling “Top siguan”can play a role of resistance ischemic injury.关键词：“Top siguan”;cerebral ischemia reperfusion;monoamine neurotransmitter;ATP enzyme
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发布时间：2022-08-31 - 摘要：Objective:To observe effects of arctigenin on expression of joint chondrocytes proliferation and Ⅱ Collagen Methods:Articlular chondrocytes were isolated by enzyme digestion method and chondrocyteⅠwere inoculated into 6 well culture plate and 96 well culture plate. The test was divided into blank group, low and high Concentration arctigenin groups. After the intervention measures for 48 hours in each group, the expression of chondrocytesⅡ Collagen were observed by SABC method and chondrocyte proliferation was tested by MTT and content of Ⅱ Collagen was tested by ELISA Results:① Compared with the blank group, the quantity of chondrocytes and the positive staining potency of the low and high Concentration arctigenin groups were significantly increased, and the increasing range of high Concentration arctigenin group was higher than the low Concentration arctigenin group. ② Compared with the blank group,OD of Concentration and contents of Ⅱ Collagen in low and high Concentration arctigenin groups were significantly increased (P<0.05), and the increasing range of high Concentration arctigenin group was higher than the low Concentration arctigenin group (P<0.05) Conclusion:Arctigenin can significantly up regulate the expression of articular chondrocytes proliferation and Ⅱ Collagen and can maintain Concentration phaenotype which can be used in the treatment of osteoarthritis effectively.关键词：Osteoarthritis;chondrocyte;Ⅱ Collagen;arctigenin
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发布时间：2022-08-31 - 摘要：Objective:To study the effect of “Bushen Huoxue Prescription” on hormone levels and expression levels of apoptosis related factors Bax,Bcl-2 and caspase-3 of granulosa cells in premature ovarian failure (POF) rats model Methods:SD rats were randomly divided into 6 groups:blank control group, model group, control group and low-dose, middle-dose and high-dose “Bushen Huoxue Prescription” groups. Premature ovarian failure rats model were set up by gavaging tripterygium wilfordii (final concentration of 50 mg/kg) for 14 days in all the groups except blank control group. Each group was treated with corresponding measures. Estrous cycle and Ovarian morphologic changes of rats were observed. Levels of E2,FSH and LH were detected by ELISA, and expression of Bax,Bcl-2 and Caspase-3 were detected by immunohistochemical method Results:① Compared with the black control group,the levels of Follicle-stimulating(FSH) in POF model in the model group were increased obviously (P<0.05). Meanwhile,the levels of lactogenic hormone (LH) in POF model increased and Estradiol (E2) were decreased too,but neither of them had a statistical difference(P>0.05). On “Bushen Huoxue Prescription” treated groups,the levels of FSH(P<0.01)and LH (except high-dose group,P<0.01) decreased significantly than the model group. E2 increased obviously (P<0.01) in “Bushen Huoxue Prescription” treated groups (but not of middle-dose)compared with POF model. ② Th Results: of immunohistochemical staining indicated that compared to the black control group,the expression levels of Bax and caspase-3 were increased obviously on ovarian granulosa cells of POF model (P<0.01),but not in Bcl-2 protein(P>0.05). The expression of Bax and caspase-3 were decreased significantly in “Bushen Huoxue Prescription” groups (P<0.01), and the expression of Bcl-2 also slightly increased(P>0.05) Conclusion:Tripterygium wilfordii glycosides could encourage rats’ ovarian granulosa cell apoptosis and POF. “Bushen Huoxue Prescription” could weaken apoptosis of ovarian granulosa cells on tripterygium wilfordii glycosides induced POF rat models via decreasing the expression level of Bax and caspase-3 proteins.关键词：premature ovarian failure;“Bushen Huoxue Prescription”;granulosa cells;apoptosis;Bcl-2;Bax;Caspase-3
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发布时间：2022-08-31 - 摘要：Objective:To investigate “Ruai Shuhou Prescription” and its disassembled prescriptions on growth of xenotransplants in pulmonary metastasis model of mice with breast cancer,and to explore the possible mechanism Methods:The pulmonary metastasis model of breast cancer was set up through subcutaneous injection of 4T1-luc cells in the second breast fat pad. 5 days after inoculation, Fifty mice bearing breast cancer were randomly divided into five groups (in each group there were 10 nude mice):control group,quanfang group,yiqi group,chongren group,jiedu group. Each group except the model group was treated with “Ruai Shuhou Prescription” and its disassembled prescriptions 30 days. Tumor inhibitory rate was calculated. The growth of tumor cells in the body was monitored by bioluminescent imaging system to monitor. The pulmonary metastasis was evaluated by lung metastases quantitative analysis. The expression levels of Foxp3、TGF-β1、CD4+ proteins in xenografts were detected by Western blotting Results:The tumor inhibitory and pulmonary metastasis inhibitory rates of treatment groups compared with control group,the difference is statistically significant(P<0.05,P<0.01); yiqi group and chongren group compared with quanfang group,the difference was statistically significant (P<0.05), while there was no statistical significance in jiedu group compared with quanfang group (P>0.05). The expression levels of Foxp3、TGF-β1 were significantly reduced and the expression levels of CD4+ were significantly increased in all treatment groups compared with control group(P<0.05,P<0.01), and there was significantly statistic difference. Compared with quanfang group,the difference of the expression of Foxp3, TGF-β1 and CD4+ of yiqi group and chongren group was statistically significant( P<0.05), and jiedu group compared with quanfang group the difference was not tatisticaly significant (P>0.05) Conclusion:“Ruai Shuhou Prescription” and its disassembled prescriptions have tumor suppression and resisting tumor metastasis,and its mechanism may be related to microenvironment of Foxp3,TGF-β1 and CD4+.关键词：“Ruai Shuhou Prescription”;breast cancer;recurrence and metastasis;mice
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发布时间：2022-08-31 - 摘要：Objective:To study the analgesic effect of Toddalia Asiatica, and to provide reference for the research and development of analgesic traditional Chinese medicine Methods:Analgesic effect of Toddalia Asiatica’s extract was investigated b Methods: of acetic acid writhing and hot plate, and the pain was induced by chemical and heat stimulation. ELISA kit was used to detect the regulation of beta-endorphin(β-EP), 5-hydroxytryptamine(5-HT), prostaglandin2(PGE2), nitric oxide(NO) in the serum of the rats; western blot was used to detect β-EP, PGE2 and Opioid receptors μ in brain tissue of rats Results:The number of rats writhing induced by acetic acid was decreased by the Toddalia Asiatica’s extract, and the ethanol extract was less than the water extract (P<0.01). The pain threshold was remarkably improved by the Toddalia Asiatica’s extract, and there was no significantly difference between ethanol extract and water extract(P>0.05). The extract could increase the content of β-EP as well as reduce the content of PGE2 and NO in the serum, and the ethanol extract has more remarkably effect(P<0.05); The extract also can increase the content of β-EP as well as reduce the expression of PGE2 in brain tissue(P<0.05) Conclusion:Toddalia Asiatica has analgesic effect, and ethanol extract was better than water extract, high dose group was better than low dose group. The analgesic mechanism maybe has the relationship with increasing β-EP, decreasing the content of PGE2 and NO, and the up-regulation of the expression of β-EP and the down-regulation of the expression of PGE2.关键词：Toddalia Asiatica Lam;analgesic effect;analgesic mechanism
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发布时间：2022-08-31 - 摘要：Objective:To supplement a reference for evaluation of quality standard of Platycodon grandiflorum through determining the contents of lobetyolin of Platycodon grandiflorum from different parts and different areas by HPLC Methods:Introject C18 (250 mm×4.6 mm, 5μm) column was applied. The mobile phase was consisted of acetonitrile-water with gradient elution and flow rate of 1.0 mL·min-1. The detection wavelength was set at 267 nm and the column temperature was set at 30 ℃ Results:The calibration curve was linear in the range of 0.065625~1.05 g/L (R2=0.999 1),and the average recovery rate was 98.24%. The contents of lobetyolin in P. grandiflorum from different parts and different areas were varied between 0.0315 and 0.4899 mg·g-1 Conclusion:There was remarkable difference in contents of lobetyolin of Platycodon grandiflorum from different parts and different areas. The method in this paper is accurate,feasible and reproducible,which can be applied as the determination of lobetyolin in P. grandiflorum and its products.关键词：Platycodon grandiflorum;lobetyolin;HPLC;quality standard
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发布时间：2022-08-31 - 摘要：This paper presents the relationship between the pathogenic wind and the occurrence of bronchial asthma, the differentiation and treatment of bronchial asthma from the perspective of wind, and the therapeutic mechanisms of wind-dispelling herbs.关键词：bronchial asthma;treatment from wind;review
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发布时间：2022-08-31 - 摘要：This article summaries the research progress on the relationship between TCM syndrome and gastroscopy pathology of chronic gastritis in recent years. Our study based on three aspects which include the relationship between syndrome and gastroscopy pathology of chronic superficial gastritis, the relationship between syndrome and gastroscopy pathology of chronic atrophic gastritis, and the relationship between syndrome and gastroscopy pathology of other types chronic gastritis. We hope to provide an Objective: general situation of the relationship between gastroscopy index and syndrome of chronic gastritis and provide reference for diagnosis, treatment and related research on chronic gastritis in the future.关键词：chronic gastritis;TCM syndrome;gastroscopy;summary
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发布时间：2022-08-31
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