WANG Tian-zhan,HUO Qing-ping,FU Xiao-dong,HE Yan-ming,WANG Wen-jian
Vol. 49, Issue 5, Pages: 36-40(2015)
摘要:Objective:To observe the clinical efficacy of “Yiqi Huaju Granules” and western medicine for the treatment of metabolic syndrome coupled with microalbuminuria Methods:One hundred cases with were randomized into treatment group and control group, with 50 cases in each group. The treatment group was treated with western medicine and “Yiqi Huaju Granules”, and the control group was treated with western medicine and placebo, with the course of 12 weeks. The negative conversion ratio of microalbuminuria was observed, and the indicators of urine (MA, UACR, 24 hTP, urinary transferring and β2 microglobulin), signs indicators (BMI, WHR, SBP, DBP, MAP), and blood sugar (FPG, 2 hPPG, HbA1c, HOMA-IR) and blood fat (TC, TG, LDL, HDL) were compared Results:①All of the 100 subjects completed the clinical study. ②The total negative conversion rate of MA was 28.00% in the treatment group and was 10.00% in the control group, with a difference between the two groups (P<0.05). ③After treatment, there were significant differences in the levels of MA, UACR, 24 hTP and urinary β2 microglobulin between the two groups (P<0.05). ④After treatment, there were significant differences in the levels of BMI, WHR, SBP and MAP between the two groups (P<0.05). ⑤After treatment, there were significant differences in the levels of FPG, 2 hPPG, HbA1c and HOMA-IR between the two groups (P<0.05). ⑥After treatment, there were significant differences in TG level between the two groups (P<0.05) Conclusion:Combined “Yiqi Huaju Granules” and western medicine is effective to control the progress of the disease, enhance the insulin sensitivity and reduce central obesity in metabolic syndrome coupled with microalbuminuria.  
YE Wu,FANG Sheng-quan,YANG Xu-ming,ZHU Sheng-liang,NI Hong-mei,WANG Xiao-su
Vol. 49, Issue 5, Pages: 41-44(2015)
摘要:Objective:To observe the clinical efficacy of “Huosu Yangwei Syrup” in treating precancerous lesions of gastric cancer Methods:Sixty cases with PLGC were randomized into treatment group and control group, with 30 cases in each group. The control group was treated with “Weifuchun Tablets” and the treatment group was treated with “Huosu Yangwei Syrup”, with the course of 3 months. The clinical efficacy, pathological changes of gastric mucosa and the levels of serum PG and the quality of life in both groups were observed and compared Results:①The total effective rate was 86.67% and 66.67% in the treatment group and control group respectively, with a difference between the two groups(P<0.05). ② There were significant differences in the levels of PGⅠ and PGⅠ/PGⅡ in the treatment group between before and after treatment (P<0.05); and significant difference was found in the PGⅠ/PGⅡlevels of the control group after treatment (P<0.05); After treatment, there were significant differences in the levels of PGⅠ and PGⅠ/PGⅡ between the two groups (P<0.05). ③In both groups, there were significant differences in gastric atrophy and intestinal metaplasia between before and after treatment (P<0.05); After treatment, no significant difference was found in atrophy and intestinal metaplasia between the two groups (P<0.05). ④ In both groups, there were significant differences in PRO scores and total scores between before and after treatment (P<0.05); After treatment, there were significant differences in the scores of spleen and stomach system, social psychological symptom and total score between the two groups (P<0.05) Conclusion:“Huosu Yangwei Syrup” is effective to reverse the trend of gastric precancerous lesions, relieve clinical symptoms, improve the quality of life in treating precancerous lesions of gastric cancer.  
关键词:precancerous lesions of gastric cancer;“Huosu Yangwei Syrup”;pepsinogen;quality of life (QOL)
摘要:Objective:To observe the clinical efficacy of “Sansang Huoxue Decoction” on pulmonary hypertension of patients with stable phase of chronic obstructive pulmonary disease (COPD) of the lung and kidney deficiency type Methods:One hundred and twenty-six patients in stable phase of COPD with pulmonary hypertension of the lung and kidney deficiency type were randomized into treatment group and control group, with 63 patients in each group. The control group was treated by routine western therapy. The treatment group was treated by “Sansang Huoxue Decoction” additionally. The treatment course was 3 months. The clinical efficacy, TCM syndrome score, mean pulmonary artery pressure, lung function, 6-minute walking distance and inflammation factors were observed Results:①The total effective rate was 82.54% in the treatment group and 41.27% in the control group, with a difference between the two groups(P<0.05). ② There were significant differences in the TCM syndrome score, 6-minute walking distance between before and after treatment of the two groups (P<0.05). The treatment group has statistically difference in mean pulmonary artery pressure (P<0.05). After treatment, there were significant differences in the TCM syndrome score and 6-minute walking distance between the two groups (P<0.05). ③There were significant differences in the levels of FEV1, RV/TLC, R5 and R20 of the treatment group between before and after treatment (P<0.05), and with significant differences in the levels of RV/TLC, R5 and R20 of the control group between before and after treatment (P<0.05); After treatment, there were significant differences in the levels of RV/TLC, R5 and R20 between the two groups (P<0.05). ④There were significant differences in the levels of IL-6, IL-8 and hs-CRP of the treatment group between before and after treatment (P<0.05), and there were significant differences in the levels of IL-6 and hs-CRP of the control group (P<0.05). After treatment, there were significant differences in the levels of IL-8 and hs-CRP between the two groups (P<0.05) Conclusion:Combined “Sansang Huoxue Decoction” and western routine western therapy is effective to lower the mean pulmonary arterial pressure, improve small airway of lung function and body inflammation, and enhance exercise tolerance in patients with COPD of the lung and kidney deficiency type.  
TAO Jian-qing,CHEN Chen,YANG Zhou-jian,ZHANG Xue-chao
Vol. 49, Issue 5, Pages: 48-51(2015)
摘要:Objective:To evaluate effect of exercise prescription combined with acupoint sticking directional through medicine to alleviate chronic obstructive pulmonary disease (COPD) in patients with clinical symptoms, improve function and quality of life of lung function Methods:Patients meet the inclusion criteria were randomly divided into two groups, the control group used the “guide” in the stable classification treatment, the treatment group based on the use of Chinese medicine prescription of rehabilitation exercise (1 years) and applicator directional medicine penetration (Sanfu days). Differences between the two groups in terms of the disease and pulmonary function, quality of life Results:In the cold, COPD incidence, pneumonia frequency in treatment group decreased significantly compared with the control group (P<0.05); lung function improved significantly than before treatment (P<0.01), and was better than that of the control group (P<0.05); in daily life, psychological anxiety score in the treatment group than the control group decreased significantly (P<0.05).ConclusionCombined exercise prescription and acupoint sticking directional medicine penetration method can reduce the number of acute onset, COPD promote lung function recovery, improve the life quality of the patients.  
关键词:chronic obstructive pulmonary disease (COPD);exercise prescription;plaster;directional medicine penetration;pulmonary function;Chinese medicine appropriate technology
摘要:Objective:To observe the clinical efficacy of “Ningmitai Capsules” and antibiotics in the treatment of acute pyelonephritis of damp-heat pouring downward pattern Methods:Ninety cases were randomized into treatment group (n=60) and control group (n=30). The control group was treated with antibiotics, and treatment group was treated with “Ningmitai Capsules” and antibiotics, with the course of 2 weeks. The clinical efficacy, symptoms score and urin Results: were observed Results:The total effective rate was 83.05% in the treatment group and 66.67% in the control group, with a difference between the two groups(P<0.05). After treatment, the scores of the clinical symptoms were significantly decreased in both groups (P<0.001), but without difference between the two groups (P>0.05). The urine bacterial negative rate was significantly higher in treatment group than that in the control group (94.28% vs 80.00%, P<0.05); the urine RBC and WBC counts were reduced after treatment and two-week follow-up visit in both groups (P<0.001) Conclusion:“Ningmitai Capsules” and antibiotics is quite effective for acute pyelonephritis of damp-heat pouring downward pattern.  
摘要:Objective:To investigate the clinical efficacy of “Huangqi Guizhi Huoluo Decoction” and rehabilitation training in treating post cerebral infarction shoulder-hand syndrome Methods:One hundred and five cases with post cerebral infarction shoulder-hand syndrome were randomly divided into the control group (n=50) and the treatment group(n=55). Patients in the control group were treated with limb rehabilitation training; while patients in the treatment group were treated with “Huangqi Guizhi Huoluo Decoction” orally, with a course of 8 weeks. The clinical efficacy, VAS scores and Fugl-Meyer scores were investigated Results:The total effective rate was 90.9% in the treatment group and 74.0% in the control group, with a difference between the two groups(P<0.05). After treatment, the VAS score was reduced in the treatment group (P<0.05), and was lower than that of the control group significantly (P<0.05); the Fugl-Meyer scores were increased in both groups after treatment (P<0.05), and the Fugl-Meyer score of the treatment group was higher than that of the controls (P<0.05) Conclusion:Combined “Huangqi Guizhi Huoluo Decoction” and rehabilitation training is effective to relieve the symptoms pain etc., and improve functional activities of the limbs for the treatment of post cerebral infarction shoulder-hand syndrome.  
WANG Qian-lei,GUO Yi-jun,WEI Hua-feng,LIU Tao,ZHOU Shi-gao
Vol. 49, Issue 5, Pages: 58-60(2015)
摘要:Objective:To observe the clinical efficacy of “Chaiqin Wendan Decoction” for the treatment of insomnia of internal disturbance of phlegm-fire of the Shaoyang disease Methods:Seventy cases with insomnia were randomized into treatment group and control group, with 35 cases in each group. Control group was treated with estazolam orally, and treatment group was treated with “Chaiqin Wendan Decoction”, with the course of 60 cases. The clinical efficacy, scores of PSQI and TCM symptoms were observed Results:① The overall effective rate was 85.7% in the treatment group and 77.1% in the control group, with a difference between the two groups(P<0.05). ② There were significant differences in PSQI score between before and after treatment in both groups (P<0.05); after treatment, there were significant differences in PSQI score between the two groups (P<0.05). ③ There were significant differences in the symptom scores of insomnia, excess phlegm, epigastric oppression, restlessness, bitter taste, dizziness, red tongue, yellow and greasy tongue coating in the treatment group (P<0.05); while there was significant difference in the symptom score of insomnia in the control group between before and after treatment (P<0.05); after treatment, there were significant differences in the symptom scores of insomnia, excess phlegm, epigastric oppression, restlessness, bitter taste, dizziness, yellow and greasy tongue coating between the two groups (P<0.05) Conclusion:“Chaiqin Wendan Decoction” has positive effect on insomnia of internal disturbance of phlegm-fire of Shaoyang disease by improving the TCM symptoms of insomnia, etc.  
关键词:insomnia;internal disturbance of phlegm-fire;“Chaiqin Wendan Decoction”;clinical observation
摘要:Objective:To observe the clinical efficacy of “Quzhi Xiaocuo Formula” and red light and blue light therapy for acne vulgaris Methods:One hundred and forty-two cases with acne vulgaris were randomized into three groups:forty-seven cases in the light therapy group were treated with red light and blue light, 47 cases in the Chinese medicine group were treated with “Quzhi Xiaocuo Formula” orally, and forty-eight cases in the combination group were treated with red light and blue light therapy and “Quzhi Xiaocuo Formula”, with the course of 8 weeks. The clinical efficacy and scores of main symptoms were observed Results:The total effective rate was 91.7% in the combination group, 78.7% in the Chinese medicine group and 68.1% in the light therapy group. The clinical efficacy of the combination group was better than those of the Chinese medicine group and light therapy group (P<0.05), and the clinical efficacy of the Chinese medicine group was better than that of the light therapy group (P<0.05). After treatment, the scores of clinical symptoms were reduced in the three groups (P<0.05); the symptom score of the combination group was lower than those of the other two groups (P<0.05), and the symptom score of the Chinese medicine group was lower than that of the light therapy group (P<0.05) Conclusion:Combined “Quzhi Xiaocuo Formula” and red and blue light therapy has certain positive effect on acne vulgaris.  
关键词:acne vulgaris;“Quzhi Xiaocuo Formula”;red and blue light
摘要:Objective:To observe the of combining therapy of Chinese medicine on T-lymphocyte and immune globulin in patients with acute mastitis Methods:①Thirty female patients as the normal group, and we observed the changes of T-lymphocyte and immune globulin in 60 cases. ②Patients in the treatment group was treated with combining therapy of Chinese medicine for 2 months. The clinical efficacy, and T-lymphocyte and immune globulin were observed Results:①After treatment, all patients in the treatment group were observed, and the total effective rate was 100%. ②Before treatment, there were significant differences in the levels of CD4+ and CD8+ between the two groups (P<0.05); in the treatment group, there were significant differences in the levels of CD3+, CD4+, and CD4+/CD8+ between before and after treatment (P<0.05). ③There were significant differences in the IgG level between the two groups (P<0.05). There were significant differences in the IgG and IgA levels between before and after treatment (P<0.05) Conclusion:Acute mastitis has close relationship with disorder of immunologic balance, and combining therapy of Chinese medicine has regulatory effect on T-lymphocyte and immune globulin in patients with acute mastitis.  
关键词:acute mastitis;plasma cell mastitis;soothing liver and clearing heat method;T-lymphocyte;immune globulin
摘要:Objective:To observe the clinical efficacy of “Yinshen Huatan Formula” and metformin in treating polycystic ovary syndrome of endomorphy type Methods:Ninety cases were randomized into Chinese medicine group, western medicine group and combination group, with 30 cases in each group. Chinese medicine group was treated with “Yinshen Huatan Formula”; western medicine group was treated with metformin and combination group was treated with “Yinshen Huatan Formula” and metformin, with the course of 3 months. The clinical efficacy, BMI, WHR, glucose metabolism, and sex hormone levels were observed Results:①The overall effective rate was 70.00%, 76.67% and 83.33% in the Chinese medicine group, western medicine group and combination group respectively; with significant differences among the groups(P<0.05). The clinical efficacy of the combination group was superior to that of the other two groups. ②There were significant differences in the levels of BMI, WHR between before and after treatment in the combination group(P<0.05); After treatment, the levels of BM and WHR in the combination group were lower than those of the other two groups(P<0.05). ③ There were significant differences in the levels of FINS and HOMA-IR between before and after treatment in western medicine group and combination group(P<0.05); After treatment the levels of FINS and HOMA-IR of the western medicine group and combination group were lower than that of the chinese medicine group(P<0.05). ④ There were significant differences in the levels of LH and T between before and after treatment in Chinese medicine group and combination group (P<0.05); After treatment, the levels of LH and T of the Chinese medicine group and combination group were lower than that of the western medicine group (P<0.05) Conclusion:Combined “Yinshen Huatan Formula” and metformin can alleviate clinical symptoms and regulate endocrine condition and boost the ovulation in treating PCOS of the endomorphy type.  
摘要:Objective:To observe the clinical efficacy of “Bushen Huoxue Decoction” for the treatment of recurrent spontaneous abortion Methods:Seventy-four cases with recurrent spontaneous abortion were randomized into treatment group (n=39) and control group (n=35). Treatment group was treated with “Bushen Huoxue Decoction” and control group was treated with “Bushen Guchong Pills”, with the course of 4 weeks. The clinical efficacy was observed. Condition of natural labor was follow-up visited, and changes of blood HCG, progesterone and blocking antibody were compared before and after treatment Results:The total effective rate was 94.87% in the treatment group and 82.86% in the control group, with a difference between the two groups(P<0.05). ②After treatment, levels of blood HCG was increased along with the increase of gestational age (P<0.05), while blood P levels showed less correlation with time in both groups (P>0.05). And during 7-9 gestational weeks, there was significant difference in the blood HCG levels between the two groups (P<0.05), and no difference was found in blood P level between the two groups (P>0.05). ③ There were significant differences in the levels of BE-Ab1 and BE-Ab2 between treated for 2 weeks and before treatment in both groups (P<0.05), but no significant difference was found in the levels of anti-CD3-BE, anti-CD4-BE and anti-CD8-BE in both groups (P>0.05); after 2 weeks treatment, there were significant differences in the levels of BE-Ab1 and BE-Ab2 between the groups (P<0.05), while no significant difference was found in the levels of anti-CD3-BE, anti-CD4-BE and anti-CD8-BE between the two groups (P>0.05). ④ Thirty-five cases deliveried in the treatment group and 29 cases in the control group. No significant difference was found between the two groups (P>0.05) Conclusion:“Bushen Huoxue Decoction” has positive effect on protecting the fetus and treating recurrent spontaneous abortion.  
关键词:recurrent spontaneous abortion;“Bushen Huoxue Decoction”;blocking antibody;immunoprotection;miscarriage prevention with Chinese medicine;sex hormone
摘要:Objective:To observe the clinical efficacy of three-colored cream and chitosan for the treatment of knee osteoarthritis Methods:One hundred and twenty cases with knee osteoarthritis were randomized into observation group and control group, with 60 cases in each group. Both groups were treated with articular cavity lavage therapy; simultaneously, the control group was treated with chitosan by intra-articular injection, and the observation group was treated with intra-articular injection of chitosan and external application of three-colored cream, with the course of 6 weeks Results:The total effective rate was 93.3% in the observation group and 71.7% in the control group, with a difference between the two groups (P<0.05). After treatment, the WOMAC scores were decreased in both two groups (P<0.05), and WOMAC score of the observation group was lower than that of the control group (P<0.05) Conclusion:Combined three-colored cream and chitosan has positive effect in improving the clinical efficiency and the function of joints for the treatment of knee osteoarthritis.  
关键词:knee osteoarthritis;three-colored cream;function of joint
摘要:Objective:To observe the clinical efficacy of “Dilong Shuyao Capsules” in treating lumbar disc herniation of the cold dampness type Methods: One hundred and thirty cases with lumbar disc herniation of the cold dampness were randomly divided into the treatment group and control group, with 65 cases in each group. The treatment group was treated with “Dilong Shuyao Capsules” and the control group was treated group was treated with “Fengshi Gutong Cauples”, with the course of one month. The clinical efficacy was observed and the changes of pain visual analogue scale (VAS), lower back pain score (JOA), and straight leg raising angle (SLR) were compared Results:①The total effective rate was 90.77% in the treatment group and 73.85% in the control group, with a difference between the two groups(P<0.05). ② Comparing before and after treatment in both groups, VAS and JOA scores of both groups were statistically significant (P<0.05); after treatment there was significant differences in the VAS and JOA scores between the two groups (P<0.05). ③Comparing before and after treatment in both groups, there were significant differences in the SLR level (P<0.05); Comparing the two groups after treatment, the difference in SLR level was significant (P<0.05) Conclusion:“Dilong Shuyao Capsules” is effective to relieve the symptoms of pain and limited mobility and improve the quality of life in patients with lumbar disc herniation of the cold dampness type.  
摘要:This article introduces Prof. Lu Deming’s experience in differentiating and treating postoperative metastatic breast cancer. It is believed that deficiency of healthy qi and residual poison are the etiology and pathogenesis; reinforcing the healthy qi and regulating yin and yang are the therapeutic principles; combination of diseases and syndromes differentiation, and the flexible application of classical formula should be paid attention to in clinic. Simultaneously, regulating emotions and diet should be emphasized. One prove case is presented.  
关键词:breast cancer;postoperative metastasis;postoperative prescription for breast cancer;famous doctor’s experience;Lu Deming
摘要:Chinese medicine physique theory is the foundation stone of spinal manipulation. “Bone Joint Semidislocation and Tendon off-position” is a core element of change of spinal disease pathology, and an important target for the implementation of the spine manipulation. The manipulation in the treatment of cervical spondylosis has exact curative effect and easy promotion clinical characteristics and advantages. Shi’s Department of Traumatology has hundred years of experience by combining inheritance and innovation in clinical practice. Based on the facts, this article elaborates the technical specification of Shi’s manipulation to correct cervical spine bone joint semidislocation and tendon off-position.  
关键词:cervical spondylosis;Bone Joint Semidislocation and Tendon off-position;Shi’s department of traumatology;correct manipulation;technical specification
LIN Feng-xia,LEI Cai-yun,DING Chen-chen,SHI Li,ZHANG Si-fang
Vol. 49, Issue 5, Pages: 8-11(2015)
摘要:Objective:To analyze the principles of Chinese medicine for the treatment of chronic renal failure (CRF) based on literature analysis Methods:Search and screen out the articles published through the database from 2004 to 2014 on Chinese medicine for the treatment of CRF with Chinese medicine. We analyzed the composition, function category and therapeuti Methods: of the medicine by frequency analysis, factor analysis and cluster analysis to discuss the medication law Results:①Seventy-three articles were involved in the research, collecting 73 prescriptions and 131 kinds of herbs and 784 times of total medicine frequency. ②Through factor analysis and frequency analysis, the herbs which can mostly reflect the treating principles are the 15 kinds:Dahuang (Radix et Rhizoma Rhei), Huangqi (Radix Astragali seu Hedysari), Danshen(Radix Salviae Miltiorrhizae), Fuling(Poria), Baizhu(Rhizoma Atractylodis Macrocephalae), Danggui(Radix Angelicae Sinensis), Xianlingpi(Herba Epimedii), Chuangxiong(Rhizoma Ligustici Chuanxiong), Dangshen(Radix Codonopsis), Banxia(Rhizoma Pinelliae), Tufuling(Poria), Shanzhuyu(Fructus Corni), Gouqi(Fructus Lycii), Niuxi(Radix Achyranthis Bidentatae), Duzhong(Cortex Eucommiae). ③Treatment frequency shows that measures like purging fu-organs and Turbid-Expelling, nourishing qi to invigorate spleen, activating blood and tonify the liver and kidney are the most widely used. ④Cluster analysis reveals two significant herb combinations:C1[Dahuang(Radix et Rhizoma Rhei), Huangqi(Radix Astragali seu Hedysari), Danshen(Radix Salviae Miltiorrhizae)] and C2[Fuling(Poria), Baizhu(Rhizoma Atractylodis Macrocephalae), Danggui(Radix Angelicae Sinensis)] Conclusion:Treating CRF with Chinese medicine can focus on the “weakness” “turbid” and “stasis”, so the main therapies are tonifying deficiency, purging fu-organs and expelling turbid, activating blood, dissipating dampness and poison. The most frequently used medicines are Dahuang(Radix et Rhizoma Rhei), Huangqi(Radix Astragali seu Hedysari), Danshen(Radix Salviae Miltiorrhizae), Fuling(Poria), Baizhu(Rhizoma Atractylodis Macrocephalae), etc.  
摘要:This paper introduces professor Wei’s clinical experience in treating breast precancerous lesions with “Xiaotan Jieyu Forumula”. It is argued that “phlegm toxin” and “qi stagnation” are the basic pathogenesis. Eliminating phlegm and relieving depression are the therapeuti Methods:. One proven case is presented.  
WANG Xin,TANG Jin-yang,ZHOU Cai-yun,DU Li-yan,HAN Shu-hua,FANG Ding-ya
Vol. 49, Issue 5, Pages: 18-21(2015)
摘要:This paper introduces Prof. Fang’s experience in treating cutaneous vasculitis related to immunity with special prescriptions. It is argued that disease differentiation and syndrome differentiation should be considered simultaneously, and treats special disease with special prescription. The representative prescription “Xijiao Dihuang Decoction” with the function of clearing heat, dissipating toxin and cooling blood should be used. Patients with insufficiency of blood, external invasion of wind toxin should be treated with “Danggui Syrup” to nourish blood and eliminate wind; patients with damp heat and stagnated toxin should be treated with “Mahuang Lianqiao Chixiaodou Decoction” to clear heat and resolve damp. Three proven cases are presented.  
摘要:This paper discusses Professor Zhao Heping’s experience in treating Bi syndrome by th Methods: of warming yang to dispel cold, clearing heat and disinhibiting dampness, clearing away heat to remove toxin, using cold and warm herbs simultaneously, invigorating spleen to resolve dampness, replenishing qi and blood, nourishing yin to dredge collaterals, activating blood circulation to dredge collaterals, nourishing kidney and eliminating phlegm and blood stasis, eliminating evils with insects etc. The common used herbs are presented.  
摘要:This paper introduces Prof. Shi’s clinical experience with dysmenorrheal. It is argued that dysmenorrheal can be divided into two types of primary dysmenorrheal and secondary dysmenorrheal. The former one can be seen in liver depression pattern and should be treated with modified “Tongjing Decoction”; the later one can be seen in cold stagnation and blood stasis pattern, which can be treated with modified “Xingui Zhitong Formula”. One proven case is presented respectively.  
LIU Qi,CHEN Yan,GU Qiu-zhi,LU Huan-yu,HUANG Zhi-bin,WANG Lei,LU Chuan-jian
Vol. 49, Issue 5, Pages: 27-29(2015)
摘要:This paper expounds the relationship between clinical application of “Zhenwu Decoction” and earth-invigorating thoughts. It discusses the theoretical connotation of earth-invigorating thoughts in works of classical philosophy and Chinese medicine, and analyzes the basic significance and clinical application of “Zhenwu Decoction” in Treatise on Febrile Diseases. The water metabolism, earth-invigorating thoughts and application of “Zhenwu Decoction” were discussed. Two proven cases are presented.  
摘要:This paper introduces the theoretical basis for treatment of idiopathic pulmonary fibrosis in network, combining with literature reports of compound Chinese medicine for idiopathic pulmonary fibrosis (IPF) in recent years, and summarizes the main therapeuti Methods: of supplementing qi and nourishing yin, activating blood to dredge collaterals, eliminating phlegm to dredge collaterals, regulating lung to dredge collaterals, etc. Aims to regulate the cytokine network, and inhibit extracellular matrix synthesis and promote its degradation, regulation of oxidative stress and coagulation fibrinolys.  
关键词:collateral disease;idiopathic pulmonary fibrosis (IPF);compound Chinese medicine;mechanism
摘要:This paper discusses application of blood-letting therapy in clinic for the aspects of needling-selection, location, specification, indication etc. Six proven cases are presented.  
摘要:This paper presents the herbal actions of Fructus Chaenomelis and its clinical application, specifically softening liver and harmonizing stomach, activating qi and resolving dampness, unblocking obstruction and soothing sinew, astringing urine and hidroschesis.  
摘要:Combining with the ancient and modern literature researches and self-experience, this paper reviews the mechanism of Semen Strychni for the treatment of myasthenia gravis. Its therapeutic mechanism is manifested by benefiting qi to strengthen muscles, supporting healthy qi, removing toxic materials and dissipating nodules, resolving stagnation to dredge collaterals, etc.  
摘要:Objective:To explore the effects of “Shaoyao Gancao Decoction” on excitatory/inhibitory amino acid level in patients with spastic hemiplegia after cerebral ischemia-reperfusion (CI/RP) and to explore its mechanism Methods:Ninty-four model SD rats were randomly divided into the model group, Shaoyao Gancao group, Shaoyao group, Gancao group, baclofen group and sham-operated group. Implementing ischemia reperfusion after 2 hours of right middle cerebral artery embolism surgery was used as research model, to screen rats that had obvious hemiplegia with spasm as the research subjects. Intervention implemented among groups after 24 hours of CI/RP, and rats were treated for 9 days consciously. The attitudinal reflex, muscular tension and levels of levels of glutamic acid (Glu), aspartic acid (Asp), γ-aminobutyric acid (GABA) and glycine (Gly) in brain tissues and serum were observed Results:①Scores of postural reflex assessment of rats were improved significantly in the “Shaoyao Gancao Decoction” group and Shaoyao group (P<0.01, P<0.05). ② The musclar tension of rats was relieved significantly in the “Shaoyao Gancao Decoction” group and baclofen group (P<0.05). ③ Gly contents in brain tissue of the “Shaoyao Gancao Decoction” group was lower than that of the Gancao group (P<0.05). ④The GABA content in brain tissue of the baclofen group was obviously lower than that of the model group (P<0.01). ⑤Serum level of Glu and Asp of the “Shaoyao Gancao Decoction” group, Shaoyao group and the baclofen group were significantly lower than that of the model group (P<0.05, P<0.01). ⑥The serum Gly level of the Gancao group was obviously higher than that of the “Shaoyao Gancao Decoction” and the Shaoyao group (P<0.05) Conclusion:“Shaoyao Gancao Decoction” can improve the postural reflex assessment scores and the degree of spasm in rats after CI/RP. Its mechanism might be related to the decrease of excitatory amino acids content in serum and Gly in brain tissues of rats with hemiplegia and spasm after CI/RP.  
DA Wei-wei,ZHAO Yong-jian,WANG Yong-jun,CHENG Shao-dan,SHI Qi,TANG De-zhi
Vol. 49, Issue 5, Pages: 90-94(2015)
摘要:Objective:To observe the effect and mechanism of Icariin on proliferation and differentiation of osteoblasts Methods:The preosteoblastic cell lines OCT1 cells were cultured under the routine method, then intervened for 48 hours with Icariin, at the concentration of 10ug/mL, 30ug/mL and 60ug/mL respectively, and the purified protein BMP2 (50μg/L) as a positive control. MTT method was performed to detect the proliferation rate of osteoblasts, and RT-PCR analysis was performed to observe the expression of BMP2 mRNA, Runx2 mRNA Results:Compared with the normal control group, Icariin promoted the osteoblast proliferation obviously (P<0.05); Icariin increased the expression of BMP2 mRNA and Runx2 mRNA in osteoblasts significantly (P<0.05) Conclusion:Icariin can induce the proliferation and differentiation of osteoblasts by activating the BMP signaling pathway and up-regulating the expression of Runx2 in preosteoblastic cell lines.  
关键词:cell line;osteoblast;icariin;cell proliferation;real time fluorescent quantitative (PCR)
LI Yu-mei,SHENG Xiao-ping,CHEN Yong-qiang,FAN Tian-you,WU Wen-hu
Vol. 49, Issue 5, Pages: 95-98(2015)
摘要:Objective:To detect the changes of tartrate-resistant acid phosphatase (TRACP), IL-1β and TNF-α in osteoblasts-osteoclasts co-culture system and to discuss its mechanism Methods:The osteoblasts-osteoclasts co-culture system model was established and SD rats were randomized into blank contol group, “Jiawei Sangen Decoction” groups. Six pores were set up in each group. The expressions of TRACP, IL-1β and TNF-α were detected by ELISA Results:The osteoblasts and osteoclasts were cultured and osteoblasts-osteoclasts co-culture system was set up. The TRACP in the medium and high dose “Jiawei Sangen Decoction” group were lower than that of the control group (P<0.05). Compared with the blank group, the IL-1β level in the medium and high dose “Jiawei Sangen Decoction” groups were reduced, and the TNF-α in the high dose “Jiawei Sangen Decoction” group was reduced significantly (P<0.05) Conclusion:“Jiawei Sangen Decoction” can inhibit the function of osteoclasts in osteoblasts-osteoclasts co-culture system, its mechanism may be associated with inhibiting the secretion of IL-1β and TNF-α.  
摘要:Objective:To observe the intervention effect of “Jiangqian I” on brain apoptosis and mechanism study on improvment of neurobehavior Methods:Adult Wistar rats mated by female:male=2∶1 ratio were randomly divided into normal group and the experimental group which were given distilled water or 0.2% lead acetate solution respectively from the 1st day after pregnancy until the 21 days when the offspring began to be weaned. Weaning offspring is used for the experiment. Experimental rats were randomly divided into lead-exposed model group, EDTA group, the low dose “Jiangqian I” group, the middle dose “Jiangqian I” group and the high dose “Jiangqian I” group. The normal group used as blank group. Their blood and brain of lead was determined by atomic absorption spectrophotometry. Effects of learning and memory capacity of offspring after the medication were observed with Y-maze and apoptotic cells condition was detected with SP immunohistochemical method Results:After treatment, the blood lead levels of lead-exposed model group was significantly decreased after detachment of Lead Pollution (P<0.001). After treatment, the brain lead levels of EDTA group and the low dose “Jiangqian I” group were significantly lower than those of the model group (P<0.05). There are no significant difference between the brain lead levels of “Jiangqian I” group and those of EDTA (P>0.05); The rate of memory maintenance of the low and high dose “Jiangqian I” group were significantly higher than those of the model group (P<0.05, P<0.001). The rate of memory maintenance of the low dose “Jiangqian I” group were significantly higher than those of the EDTA group (P<0.01). The rate of memory maintenance of the low dose “Jiangqian I” group were significantly higher than those of the middle group (P<0.05); the apoptosis index of each treatment group were significantly lower than those of the model group (P<0.05, P<0.01) Conclusion:“Jiangqian I” can reduce blood and brain lead of lead exposed offspring, amend the impairment of brain tissue of lead exposed offspring in different degrees.  
关键词:“Jiangqian I”;lead;apoptosis;ability of learning and memory
摘要:Objective:To observe the therapeutic effect of “Guizhi Fuling Pills” in treating dysmenorrheal models Methods:Take the method of intravenous of oxytocin to rats, to observe the effect of “Guizhi Fuling Pills” on rats’ uterine smooth muscle in vivo; the rat models of dysmenorrhea were established by intraperitoneal injection of oxytocin, to observe the effect of “Guizhi Fuling Pills” on dysmenorrhea modeld; by using capillary glass tube method, we observed the influence of “Guizhi Fuling Pills” on blood clotting time in mice; acute blood stasis rat models were established by the method of ice water bath and intraperitoneal injection of epinephrine. Observed the hemorheological effects of “Guizhi Fuling Pills” and the anti-inflammatory action of “Guizhi Fuling Pills” on mice ear swelling induced by xylene Results:Compared with the model group, uterine smooth muscle contraction in vivo of each dose group treated with “Guizhi Fuling Pills” were decreased obviously (P<0.05); number of mice body torsion reaction occurred within 15 min were obviously decreased (P<0.05) and blood clotting time in mice were significantly prolonged (P<0.05); the blood viscosity, plasma viscosity, erythrocyte sedimentation rate (ESR) and erythrocyte electrophoresis time (EET) were reduced significantly (P<0.05), and the prothrombin time was prolonged (P<0.05); mice ear swelling in high, middle dose group treated with “Guizhi Fuling Pills” was significantly reduced (P<0.05) Conclusion:“Guizhi Fuling Pills” has obvious effects on inhibition of excessive contraction of rats uterine smooth muscle in vivo, analgesia, anticoagulation and anti-inflammation, and have good therapeutic effects on dysmenorrhea.  
摘要:Objective:To isolate and extract the chemical constituents from Pholiota adipose Methods:Column chromatography on silica gel and Sephadex LH-20 were applied to isolate and purify Pholiota adipose. MS and NMR data analysis were used to identify its structure Results:Fifteen compounds were isolated and purified and their structures were identified as adenosine(1), ergosterol peroxide(2), (22E, 24R)-23-methylergosta-7,2-diene-3β, 5α, 6β-triol(3), Glycerol alpha-Monopalmitate(4), Glyceryl monooleate(5), Cerevisterol(6), D-mannitol(7), benzoic acid(8), Glyceryl-1,2-dioctadec-9,2-dienoate-3-octadec-9-enoate(9), 1,3-Diolein(10), β-sitosterol(11), 1-Tricosanol(12), 9,12-Octadecadienoic acid,methyl ester(13), ergosta-7,2-dien-3β-ylpalmitate(14), (22E, 24R)-ergosta-7,2-dien-3β, 5α, 6β-triol(15) Conclusion:All compounds were first separated from greasy scales umbrella Pholiota adiposa.  
摘要:This paper reviews the related literatures on cell models such as diabetes insulin resistance cell models and islet cell models, and introduces the research progress on drug serum and monomer of Chinese herbs in vitro. The diabetes cell models are mainly target tissue cells and insulinoma isolated cells. Aims to provide references for the further research on screening of Chinese herbs and its hypoglycemic mechanism.  
摘要:This article reviews the literatures on treatment of Parkinson’s disease (PD) by acupuncture in recent 15 years and expounds the research progress of scalp acupuncture for PD from the aspects of clinical symptoms and mechanisms. It is believed that scalp acupuncture therapy can effectively relieve the motor symptoms, cognitive impairment and mental symptoms caused by PD, delay the course of the disease and improve the quality of life for PD patients.