最新刊期
期 4 ， 2015
- 摘要：Objective:To observe the clinical efficacy of “Elian Granules” in treating chronic atrophic gastritis (CAG) of spleen deficiency and heat stagnation pattern accompanied with intestinal metaplasia Methods:Ninety cases with CAG of spleen deficiency and heat stagnation pattern accompanied with intestinal metaplasia were randomized into three groups:treatment A group (group A), treatment B group (group B) and control group (group C), with 30 cases in each group. Group C was treated with “Wei Fuchun Tablets”, group B was treated with “Elian Granules” at the common dosage and group A was treated with “Elian Granules” at the high dosage, with the course of 12 weeks. The safety was evaluated Results:① Eighty cases finished the trail, with 28 cases in group A, 26 cases in group B and 26 cases in group C. ② For full analysis set (FAS), the clinical efficacy was 96.67%, 93.33% and 66.67% respectively, with significant difference among these groups (P<0.05), and there were also significant difference between group A and C as well as between group B and C (P<0.05). ③ In each group, there was significant differences in grade of atrophy and intestinal metaplasia between before and after treatment (P<0.05); after treatment, significant difference was found in grade of atrophy and intestinal metaplasia between group A and C as well as group B and C (P<0.05). ④ In each group, there was significant difference in TCM symptoms after treatment (P<0.05). ⑤ No significant difference was found in occurrence rate of adverse reaction among the groups (P>0.05) Conclusion:“Elian Granules” can effectively improve the clinical symptoms and safely reverse the gastric mucosa pathology in patients with CAG accompanied with intestinal metaplasia.关键词：chronic atrophic gastritis (CAG);intestinal metaplasia;precancerous lesions of gastric cancer;spleen deficiency and heat stagnation;“Elian Granules”
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发布时间：2022-08-31 - 摘要：Objective:To observe the clinical efficacy of “Qingxia Jieyi Decoction” by nasal feeding and enema therapy with western medicine in treating severe acute pancreatitis (SAP) Methods:Fifty-six cases with SAP were randomized into two groups:control group in which 27 cases were treated by conventional western therapy and treatment group in which 29 cases were treated by combination of the western medicine and “Qingxia Jieyi Decoction”, with the course of 14 days. The Ranson scores at 48 hours after admission, and changes of white blood count (WBC), blood urea nitrogen (BUN), fasting blood glucose (FBG), Ca2+, C reactive protein (CRP) at 24h and 72h were observed. The clinical complications during the course of treatment were compared Results:① Between before treatment and 48h after treatment in each group, there was statistic significance in Ranson scores in the treatment group (P<0.05); after treatment, there was significant difference in Ranson scores between the two groups (P<0.05). ② In each group between before and 72h after treatment, there were significant differences in the levels of WBC, BUN, FBG, Ca2+ and CRP in the treatment group (P<0.05), and with significant differences in the levels of WBC, BUN and CRP in the control group (P<0.05). Between 24h and 72h after treatment in each group, there were significant differences in the levels of WBC, BUN, FBG and CRP of the treatment group (P<0.05), and there were significant differences in the levels of WBC, BUN and CRP of the control group (P<0.05). There were significant differences in the levels of FBG, Ca2+ and CR at 72h after treatment between the two groups (P<0.05). ③ During the treatment course, there were significant differences in the incidence of the pancreatic abscess as for the local complication and the pleural effussion and the ARDS as for the systemic complication between the two groups (P<0.05). There were significant differences in the mixed complications between the two groups (P<0.05) Conclusion:Combined “Qingxia Jieyi Decoction” and western medicine is effective to control the inflammatory response, relieve pancreas lesion and reduce complication for the treatment of severe acute pancreatitis.
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发布时间：2022-08-31 - 摘要：Objective:To observe the clinical efficacy of “Yimu Futu Formula” for the treatment of diarrhea-predominant irritable bowel syndrome (IBS-D) of liver qi subjugating spleen pattern Methods:Sixty cases with IBS-D were randomized into treatment group and control group, with 30 cases in each group. The treatment group was treated with “Yimu Futu Formula”, and control group was treated with pinaverium bromide, with the course of 4 weeks. The clinical efficacy, IBS symptom score and life quality score were observed Results:The total effective rate was 93.3% in the treatment group and 73.3% in the control group, with a difference between the two groups (P<0.05). After treatment, the IBS symptom score in both groups were decreased (P<0.01), and the reduction of symptom score in the treatment group was much more than that of the controls (P<0.05, P<0.01). After treatment, the life quality score in both groups were decreased (P<0.01), and increase of the treatment group was much more than that of the controls (P<0.01) Conclusion: “Yimu Futu Formula” is effective to improve the clinical symptoms in patients with IBS-D and improve their quality of life.关键词：“Yimu Futu Formula”;diarrhea-predominant irritable bowel syndrome (IBS-D);liver qi subjugating spleen pattern
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发布时间：2022-08-31 - 摘要：Objective:To observe the effect of “Xinnaoning Capsules” on brain natriuretic peptide (BNP) and high sensitive C-reactive protein (hs-CRP) in senile patients with diastolic heart failure (DHF) Methods:Fifty cases with DHF were randomized into treatment group and control group, with 25 cases in each group. Both groups were treated with conventional therapy and treatment group was added with “Xinnaoning Capsules” orally, with the course of 8 weeks. The levels of BNP and hs-CRP in both groups were observed before and after treatment Results:After treatment, the levels of BNP and hs-CRP were decreased in both two groups (P<0.05), and the treatment group was lower than that of the controls (P<0.05) Conclusion:“Xinnaoning Capsules” can improve the cardiac function in patients with DHF effectively.关键词：diastolic heart failure (DHF);“Xinnaoning Capsules”;brain natriuretic peptide (BNP);high sensitive C-reactive protein (hs-CRP)
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发布时间：2022-08-31 - 摘要：Objective:To observe the clinical efficacy of “Tianma Gouteng Granules” and its effect on vascular function in treating patients with primary hypertension Methods:One hundred and seven cases with primary hypertension were randomized into control group (n=53) and observation group (n=54). The control group was treated with Nifedipine controlled-release Tablets orally, and observation group was treated with “Tianma Gouteng Granules” additionally, with the course of 3 months. The clinical efficacy and contents of FMD, CIMT, SOD, ET and MDA were observed Results:①The total effective rate was 94.4% in the observation group and 81.1% in the control group, the clinical efficacy of the treatment group was superior to that of the control group (P<0.05). ② After treatment, the FMD was increased in both two groups (P<0.05), the observation group was higher than that of the controls (P<0.05); but IMT was decreased in both groups (P<0.05), and the observation group was lower than that of the controls (P<0.05). ③After treatment, the SOD was increased in both two groups (P<0.05), and observation group was higher than the controls (P<0.05); levels of ET and MDA in both groups were decreased (P<0.05), and the observation group was lower than that of the control group (P<0.05) Conclusion:“Tianma Gouteng Granules” is effective to improve the clinical efficacy, improve vascular function and antioxidant activity in patients with primary hypertension.关键词：“Tianma Gouteng Granules”;Nifedipine Controlled-release Tablets;primary hypertension;vascular function
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发布时间：2022-08-31 - 摘要：Objective:To observe the clinical efficacy of needling the antagonistic muscle acupoints and joint rehabilitation training for spasm of lower limbs after cerebral apoplexy Methods:Eighty cases with lower limbs spasm after cerebral apoplexy were randomly divided into treatment group and control group, with 40 cases in each group. Both groups were treated with conventional western medicine, scalp acupuncture and rehabilitation training. Control group was added with traditional acupuncture, and treatment group was added with needling the antagonistic muscle acupoints therapy, with the course of 34 days. The clinical efficacy was observed and spasm of modified Ashworth rating (MAS), FMA and Barthel index were compared Results:① The overall effective rate was 82.50% in the treatment group and 70.00% in the control group, with a difference between the two groups (P<0.05). ② In each group, there were significant differences in MAS, FMA and Barthel index between before and after treatment (P<0.05); after treatment, there were significant differences in MAS, FMA and Barthel index between the two groups (P<0.05) Conclusion:Combined needling antagonistic muscle acupoints and rehabilitation training can relieve spasm of lower limbs and enhance the mobility in patients with lower limbs spasm after cerebral apoplexy.关键词：cerebral apoplexy;spasm of lower limb;acupuncture therapy;antagonistic muscle acupoint;rehabilitation training
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发布时间：2022-08-31 - 摘要：Objective:To observe the clinical efficacy of five-step tuina therapy for the treatment of peripheral facial paralysis Methods:Seventy-two cases with peripheral facial paralysis were randomly divided into treatment group and control group, with 36 cases in each group. Both groups were treated with infrared radiation. Control group was added with conventional acupuncture therapy, treatment group was added with five-step tuina therapy, with the course of 10 days. The clinical efficacy and facial nerve function were observed Results:① The total effective rate was 94.44% and 83.33%, with a difference in clinical efficacy between the two groups (P<0.05). ②In both groups, there were significant difference in the facial nerve function grading between before and after treatment (P<0.05); and with significant difference between the two groups after treatment (P<0.05) Conclusion:“Five-steps Tuina Therapy” has positive effect on peripheral facial paralysis.关键词：peripheral facial paralysis;Tuina;infrared radiation;acupuncture
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发布时间：2022-08-31 - 摘要：Objective:To observe the clinical efficacy of Kongfu and tuina in treating cervical spondylosis and to conduct 6-month follow-up Methods:One hundred and sixty-two cases with cervical spondylosis were randomized into treatment group and control group, with 81 cases in each group. Control group was treated by tuina for two weeks, without any intervention during the 6-month follow-up; treatment group was treated by Kongfu for two weeks in addition, and did exercises during the follow-up. The numeric pain rating scale (NPRS), neck disability index (NDI), physical component score (PCS) and mental component score (MCS) in the short form 36 health survey scale (SF-36) and cervical flexibility were evaluated and 6-month follow-up Results:① In each group, there was significant difference in the levels of NPRS and NDI at week0, week2 and week26 (P<0.05); in the treatment group, there was a significant difference during the two periods:week0-2 and week0-26 (P<0.05), but only significant difference was found in the control group during week0-2 (P<0.05); in the treatment group, there was a significant difference in MCS during the week0-26 (P<0.05), while with significant difference in the control group during week0-2 (P<0.05). There were significant differences in the levels of NPRS and NDI at week2 between the two groups (P<0.05); with significant differences in the levels of PCS and MCS at week26 (P<0.05). ② In each group, there was significant differences in the range of motion between week0 and week2 (P<0.05); at week2, there was significant differences in the range of motion between the two groups (P<0.05). ③ No significant difference was found in adverse reaction between the two groups (P>0.05) Conclusion:Combined Kongfu and tuina can alleviate neck pain and relieve dysfunction of neck in treating cervical spondylosis.关键词：cervical spondylosis;Kongfu;Tuina;clinical efficacy;follow-up
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发布时间：2022-08-31 - 摘要：Objective:To observe the clinical efficacy of electro-acupuncture therapy of different frequencies in treating cervical spondylotic radiculopathy Methods:Ninety-four cases were randomized into group Ⅰ (n=31), group Ⅱ (n=31) and group Ⅲ (n=32). These three groups were treated by electro-acupuncture therapy on bilateral Dazhu (BL11), Tianzhu (B 10) and neck Paravertebrals of 2 Hz, 50 Hz and 100 Hz respectively. After treated for 14 times, we observed the clinical efficacy, neck pain, radiating pain and numbness of upper neck top and upper limbs, and squeezing test was conducted Results:The total effective rate was 80.6% in group Ⅰ, 83.9% in group Ⅱ and 93.8% in group Ⅲ; clinical efficacy of the in group Ⅲ was superior to that of the group Ⅰ and group Ⅱ (P<0.05). After treatment, the neck pain score was reduced in group Ⅰ (P<0.05), and scores of the neck pain, radiating pain or numbness of upper neck top and upper limbs were decreased markedly in group Ⅱ (P<0.05), and scores of the neck pain, radiating pain or numbness of upper neck top and upper limbs and squeezing test were reduced markedly (P<0.05). After treatment, there were significant differences in scores of radiating pain or numbness of upper neck top and upper limbs and squeezing test between group Ⅲ and group Ⅰ (P<0.05). There were significant difference in foramen intervertebrale squeezing test between group Ⅲ and group Ⅱ (P<0.05). No significant difference was found in indicators between group Ⅰ and group Ⅱ (P>0.05) Conclusion:Electro-acupuncture therapy of different frequency can improve the symptoms and signs such as neck pain, radiating pain and numbness of upper neck top and upper limbs and so on, especially the high- frequency electro-acupuncture.关键词：cervical spondylotic radiculopathy;electro-acupuncture;frequency
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发布时间：2022-08-31 - 摘要：Objective:To observe the clinical efficacy of “Shugan Bushen Formula” and bromocriptine for the treatment of hyperprolactinemia of liver depression and spleen deficiency pattern Methods:Sixty cases with hyperprolactinemia of liver depression and spleen deficiency pattern were randomized into western medicine group and combination group, with 30 cases in each group. Western medicine group was treated with western medicine and combination group was treated with “Shugan Bushen Formula” and bromocriptine, with the course of 3 months. The TCM symptoms and PRL levels were observed Results:The total effective rate was 90.0% in the combination group and 73.3% in the western medicine group, TCM symptoms of the combination group was superior to that of the western medicine group (P<0.05). After treatment, the TCM symptoms and serum PRL levels of the combination group were decreased markedly (P<0.05); In the western medicine group, the PRL levels was decreased markedly, but improvement of TCM symptoms was not markedly (P>0.05); TCM symptoms score and PRL levels of the combination group were superior to that of the western medicine group (P<0.05) Conclusion:Combined “Shugan Bushen Formula” and bromocriptine can reduce PRL level and improve clinical symptoms and has positive effects on hyperprolactinemia.关键词：hyperprolactinemia;liver depression and spleen deficiency pattern;integrated Chinese and western medicine;“Shugan Bushen Formula”
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发布时间：2022-08-31 - 摘要：Objective:To observe the clinical efficacy of “Zishen Tiaogan Decoction” in the treatment of postpartum depression Methods:Eighty-four subjects with postpartum depression were randomized into two groups:control group in which 42 cases were treated with Fluoxetine Hydrochloride Capsules, and treatment group in which 42 cases were treated with “Zishen Tiaogan Decoction”, with a course of eight weeks. The clinical efficacy and HAMD scores were evaluated Results:The overall effective rate was 88.1% in the treatment group and 76.2% in the control group, with better efficacy in the treatment group than that in the control group (P<0.05). After treatment, HAMD scores were significantly reduced in both groups (P<0.05, P<0.01), with lower score in the treatment group than that in the control group (P<0.05) Conclusion:“Zishen Tiaogan Decoction” is quite effective for postpartum depression.关键词：postpartum depression;“Zishen Tiaogan Decoction”;HAMD scale
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发布时间：2022-08-31 - 摘要：Objective:To observe the clinical efficacy of “Qufeng Runzao Decoction” for the treatment of dry eye syndrome in young women Methods:Sixty-two young women with dry eye syndrome were randomized into two groups:control group in which 30 cases were treated with Sodium hyaluronate eye drops, and treatment group in which 32 cases were treated with “Qufeng Runzao Decoction” additionally, with the course of 15 days. The clinical efficacy, break-up time (BUT) and lacrimal secretion were observed Results:The total effective rate was 90.63% in the treatment group and 73.33% in the control group, with a difference between the two groups (P<0.01). After treatment, the BUT was prolonged and lacrimal secretion was increased in both groups (P<0.01), with a significant difference in lacrimal secretion between the two groups (P<0.05, P<0.01); the recurrence rate was 24.14% in the treatment group and 63.64% in the control group, with a significant difference between the two groups (P<0.01) Conclusion:“Qufeng Runzao Decoction” has positive effect and low recurrence rate in young women with dry eye syndrome.关键词：dry eye syndrome;“Qufeng Runzao Decoction”;young women
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发布时间：2022-08-31 - 摘要：This paper introduces Prof. Peng’s experience in differentiating and treating IgA nephropathy. The pathogenesis of IgA nephropathy are deficiency of middle-qi, clear Qi can not rise and turbid Qi can not fall, dysfunction of triple Jiao, pathogenic wind, moisture generated internally and blood stasis. Four therapeuti Methods: of strengthening middle energizer to nourish qi, ascending lucidity and descending turbidity, regulating triple-Jiao, eliminating wind and dispelling water are applied and one proven case is presented.关键词：IgA nephropathy;ascending lucidity and descending turbidity;regulating triple-Jiao;eliminating wind and dispelling water;promoting blood circulation and removing obstruction in collaterals;famous doctor’s experience;Peng Peichu
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发布时间：2022-08-31 - 摘要：Combined the construction of special department for sleep disorders, this paper discusses the significance of integrative medicine. It is viewed that meticulous classification of special departments influences the benefits of patients, which need to be integrated for the development of medical science.关键词：integrative medicine;sleep disorder;Chinese medicine
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发布时间：2022-08-31 - 摘要：This paper aims to use the application of Yin-Yang theory in bone remodeling to address the nature of Yin-Yang theory in TCM. Here we propose that osteoblasts (bone-forming cells) and bone formation should be considered Yin, while osteoclasts (bone-resorbing cells) and bone resorption should be regarded as Yang. Moreover, we argue that the Yin-Yang relationship exists between osteoblasts and osteoclasts, and we conclude that the relationship between osteoblasts and osteoclasts as established in contemporary biology reflects the classic Yin-Yang in bone homeostasis. Therefore, the new Yin-Yang concept of osteoblasts and osteoclasts in bone homeostasis may strengthen the basic theory of TCM as well as guide clinical practice.关键词：bone homeostasis;osteoblast;osteoclast;Yin-Yang theory
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发布时间：2022-08-31 - 摘要：Objective:To explore the method of animal model building of knee osteoarthritis based on joints’ mechanical instability Methods:Twenty-four New Zealand white rabbits were randomly divided into three groups:normal group, 4 weeks model group and 8 weeks model group, with 8 rabbits in each group. The animals of model groups were making osteoarthritis models by operation, with medial collateral ligament (MCL) cutting off and resection of part of patellar ligament. The rabbits in normal group were only operated by skin incision and exposure of ligaments mentioned above. Animals were sacrificed at 4 and 8 weeks after operation in each group, and the serum and knees of each rabbit were taken at the same time. After HE staining, the morphological structure of articular cartilage was observed by microscope and Mankin’s score was made according to the degree of cartilage degeneration. The expressions of IL-1β, TNF-α and MMP-13 in serum were detected by immunohistochemical techniques Results:The degeneration in varying degrees was observed in articular cartilage from 4 weeks model group and 8 weeks model group, whose Mankin’s scores were significantly higher than the samples of normal group (P<0.01). Comparing with the normal group, the level of IL-1β, TNF-αand MMP-13 in serum were higher from the rabbits both of 4 weeks model group and 8 weeks model group statistically (P<0.01) Conclusion:The modeling method by cutting off MCL as well as excision of part of patellar ligament could provide an ideal animal model of knee osteoarthritis, with the advantages of simple operation, low rates of infection and mortality.关键词：knee osteoarthritis;animal model;rabbit;joints’ mechanical instability
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发布时间：2022-08-31 - 摘要：Objective:To study the relation between the syndrome of TCM of community-acquired pneumonia (CAP) combined sepsis with CRP, PCT, D-Di and to analyze the regularities of distribution of indexes among the syndrome of TCM Methods:One hundred and eighty-six CAP patients combined with sepsis were selected to investigate distribution of TCM syndrome, and the levels of CRP, PCT and D-Di were detected Results:① In the compare of constituent ratio of syndrome of TCM, the syndrome of toxic heat flourishing (22.58%), heat the ying blood (27.96%), stasis poison resistance (26.89%) is common. ② The CRP level in evil poison attack the lung group is lower than other groups (P<0.01), and there is no statistically significant difference among the syndrome of toxic heat flourishing, heat the ying blood, stasis poison resistance groups. The PCT of deficiency of both qi and yin group and toxic heat flourishing group is higher than evil poison attack the lung group (P<0.01) and is lower than heat the ying blood, stasis poison resistance groups (P<0.01). The D-Di of heat the ying blood, stasis poison resistance groups is higher than other groups significantly (P<0.01), and the stasis poison resistance group is highest. It is statistically significant difference compared with heat the ying blood group (P<0.01) Conclusion:Combined detection of PCT,D-Di for syndrome differentiation of TCM of CAP with sepsis patients has a certain reference value.关键词：community-acquired pneumonia;sepsis;syndrome of TCM;CRP;PCT;D-Di
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发布时间：2022-08-31 - 关键词：coronary atherosclerotic heart disease;chest blockage;teaching ward round
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发布时间：2022-08-31 - 摘要：This paper introduces Prof. Jiang’s experience in treating belching with “Shaoyao Gancao Decoction”, combining with his clinical proven cases. He proposes that pathological study and pharmacological research in modern medicine should be combined with patterns identification in traditional Chinese medicine. His unique thoughts on medication supply ne Methods: for the clinical treatment.关键词：belching;“Shaoyao Gancao Decoction”;clinical experience;Jiang Jian
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发布时间：2022-08-31 - 摘要：This paper introduces Professor Zhou’s experience in treating Waldenstrom’s macroglobulinemia. It is viewed that asthenia in the root and excess in the branch is the significant causes of Waldenstrom’s macroglobulinemiaw. Asthenia in the root indicates that “evil toxin stagnating in bone marrow”, and excess in the branch indicates that “deficiency of liver and spleen”. Tonifying liver and kidney for root and clearing evil toxin for the branch are the therapeutic principles. Eliminating wind to dredge collaterals and invigorating blood circulation to remove stasis should be combined with for the treatment of this disease.关键词：Waldenstrom’s macroglobulinemia;Chinese medicine;clinical experience;Zhou Yongming
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发布时间：2022-08-31 - 摘要：This paper introduces Professor Li’s experience in treating acute gouty arthritis with “Danggui Niantong Decoction”, treating Urethral Syndrome with “Kuolou Qumai Pills” and treating Tourette Syndrome with “Gujing Shengjiang Ganmai Dazao Decoction”.关键词：acute gouty arthritis;Urethral Syndrome;Tourette Syndrome;“Danggui Niantong Decoction”;“Kuolou Qumai Pills”;“Gujing Shengjiang Ganmai Dazao Decoction”;famous doctor’s experience;Li Fazhi
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发布时间：2022-08-31 - 摘要：This paper elaborates the application of classical prescriptions in Treatise on Febrile and Miscellaneous Diseases and analyzes the prescriptions and symptoms for the treatment of skin diseases in this book. Broaden the scope classical prescriptions in clinical application.关键词：Treatise on Febrile Diseases;classical prescription;skin disease
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发布时间：2022-08-31 - 摘要：This paper discusses law of syndrome differentiation of six meridians for lung-distention. Syndrome differentiation of six meridians is the principle for the treatment of lung-distention, which conforms to the development of disease. We discuss the law form six aspects:evil attacking the Taiyang meridian, Yangming meridian, Shaoyang meridian, Taiyin meridian, Shaoyin meridian, and intermingled heat and cold.关键词：Treatise on Febrile Diseases;syndrome differentiation of six meridians;lung-distention
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发布时间：2022-08-31 -
- 摘要：This paper introduces the clinical experience in treating rheumatoid arthritis by the method of activating blood circulation to dredge collaterals. It is argued that deficiency of liver and kidney is the internal factor and wind, cold, dampness, heat are the external factors. Phlegm, turbid and blood stasis are the main pathological factors. Stagnation of meridian and collaterals are the root of the disease. “Tianjia Tongbi Powder” is the basic prescription which can be applied in clinic. It can be modified based on different patterns. One proven is presented.关键词：rheumatoid arthritis;method of activating blood circulation to dredge collaterals;“Tianjia Tongbi Powder”;clinical experience
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发布时间：2022-08-31 - 摘要：This paper concludes and analyzes the actions and clinical application of Rhizoma Atractylodis, including drying dampness and activating spleen, dispersing dampness and removing blockage, exorcising evils and relieving depression, nourishing stomach and supplementing deficiency, and enriching the liver to brighten eyes.关键词：Rhizoma Atractylodis;herbal action;clinical application
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发布时间：2022-08-31 - 摘要：Objective:To investigate the relationship between interleukin 6(IL-6)and activation-induced cytidine deaminase (AICD) in precancerous lesions in colorectal cancer, to investigate the prevention and treatment role of “Xiaotan Tongfu Decoction” in the treatment of precancerous lesions in colorectal cancer Methods:Based on the classic AOM/DSS model of precancerous lesions in colorectal cancer, C57BL/6 mice were randomly divided into control group, model group, TCM (“Xiaotan Tongfu Decoction”) group, WM (sulfasalazine) group, integrative medicine group. Control group and model group were given the same amount of distilled water. TCM group were given medicine “Xiaotan Tongfu Decoction” 26 g/(kg.d), concentrate 0.2ml/d; WM group were given sulfasalazine 7.8 mg/pcs/day. Integrative group were given both “Xiaotan Tongfu Decoction” and sulfasalazine. Continuous administration of 12w Results:Compared with the normal group, the IL-6 and AICD immunohistochemical index, serum protein expression in the model group were increased, the difference was statistically significant (P<0.01). Compared with the model group, 18w IL-6 and AICD immunohistochemical index, serum protein in the TCM medicine group, WM group, Integrative Medicine group were decreased, the difference was statistically significant (P<0.05). Compared with WM group, 18w TCM group AICD immunohistochemical expression index decreased, the difference was statistically significant (P<0.05) Conclusion:“Xiaotan Tongfu Decoction” reduce the expression of inflammatory cytokines IL-6 and AICD, thereby reducing the occurrence of somatic hypermutation (somatic hypermutation, SHM) and class switch recombination (class-switch recombination, CSR), playing the role of prevention and treatment of Precancerous lesions in colorectal cancer.关键词：precancerous lesions in colorectal cancer;“Xiaotan Tongfu Decoction”;IL-6;AICD
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发布时间：2022-08-31 - 摘要：Objective:To observe Chinese herbal compound recipe and Tamoxifen on cell cycle and the expressions of CyclinD1, Bcl-2 and Bax protein of MCF-7 in breast cancer Methods:Mice were randomly divided into the model group, Tamoxifen (TAM) group, Ru combined group (Ru yanning Recipe + TAM) and Yi combined group (Yi qixiaoji Recipe + TAM) after modeling successfully. All the mice were sacrificed through pull off neck after given drug for 21 days, tumor were taken completely, then cut for different specimens. The distribution of cell cycle was detected by Flow cytometry; the expression of Bcl-2, Bax and CyclinD1 proteins was detected by Western blot method Results:In each treatment group, the proportion of cells in G0/G1 phase was increased, S phase was sharply reduced compared with the model group (P<0.01), but there was no statistical difference between Ru combined group and Yi combined group about cell ratio in the G0/G1 phase and S phase (P>0.05); The expression of Bcl-2 and CyclinD1 protein was down-regulated, Bax was up-regulated in the three treatment groups, the ratio of Bcl-2/Bax was significantly decreased, the difference was significant compared with the model group (P<0.01), there was also significant difference between two combined groups and TAM group (P<0.01), but there was no significant difference between Ru combined group and Yi combined group (P>0.05) Conclusion:Chinese herbal compound formula has function of cell proliferation inhibition, the possible mechanism is related to blockcell cycle at G0/G1 phase, down-regulate expression of CyclinD1, Bcl-2 protein and up-regulate the expression of Bax protein. There is synergy between Chinese herbal compound formula and TAM.关键词：Chinese herbal compound formula;Tamoxifen;cell cycle;cyclinD1;Bcl-2;Bax
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发布时间：2022-08-31 - 摘要：Objective:To study the effects of triptolide (TP) on proliferation and apoptosis of hepatocytes in BRL rats Methods:Culture BRL rat hepatocytes in vitro, and treat the BRL rat hepatocytes with different dosage of TP. The growth and proliferation of BRL rat hepatocytes were detected by cck-8 method. The levels of cultural supernatants ALT, AST, TNF-α, IL-10, IFN-γ were detected, and the percentage of cellular apoptosis were detected using AV/PI double staining Results:Compared with the control, after treated with different concentration of TP, the cell viability was reduced. The level of AST were significantly rised in all three TP treatment groups while the level of ALT was only significantly rised in TP (100 μmol/L) group. Furthermore, the level of IL-10 was significantly lower in TP (100 μmol/L) group Conclusion:TP treatment, over a pharmacologic concentration range, could inhibit the hepatocytes proliferation with a dose-effect relationship. The inhibition mechanism of TP may be related with the effect of inducing cellular apoptosis.关键词：triptolide;BRL rat;hepatocyte;proliferation;apoptosis
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发布时间：2022-08-31 - 摘要：Objective:To observe the effects of “Yinshen Pinggan Recipe” (YPR) on serum neuropeptide Y (NPY), calcitonin gene related peptide (CGRP), endothelin (ET) in spontaneously hypertensive rats (SHRs), and to survey its mechanisms Methods:Twenty-one twelve-week old SHRs were randomly divided into 3 groups (group YPR, group Bena, group SHR), seven age matched male Wistar-Kyoto rats were selected as normal control group (group WKY). Twelve weeks after treatment, the standard blood pressure was tested by tail-cuff measurements. The expressions of serum NPY, CGRP, ET levels were measured by commercial ELISA kits Results:The systolic blood pressure (SBP) was significantly increased in SHRs after 4 weeks, 8 weeks, 12 weeks treatment. And it could be inhibited by Yinshen Pinggan Recipe. In addition, the expression of NPY and ET were significantly increased in SHRs and inhibited by YPR, which increased the expression of CGRP Conclusion:YPR can reduce the systolic blood pressure of SHR, which was associated with the inhibition of the expression of NPY, ET and the activation of the expression of CGRP.关键词：spontaneously hypertensive rats (SHRs);hypertension;serum neuropeptide Y (NPY);calcitonin gene related peptide (CGRP);endothelin (ET)
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- 83
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发布时间：2022-08-31 - 摘要：Objective:The context was performed to investigate the antioxidant activity and anti-bacteria of the 75% (v/v) ethanol extraction of different parts from Syringa Rticulate (Bl.) Hara var. mandshurica (Maxim.) Hara Methods:The growth inhibitory activity and the lowest concentration for anti-bacteria of the two common bacteria were determined by filter paper method. And the DPPH radical-scavenging activity with different concentrations of different parts from the herb was determined by spectrophotometry method Results:The order of inhibitory effect of the ethanol extraction of the Syringa Reticulata (Blume) Hara var. on salmonella is branch > flower>leaves>bark. The order of the inhibitory effect on bacillus subtilis is leaves >branch>bark >flower. The bark of the plant has the strongest scavenging activity for DPPH radical, which was better than flower, branch and leaves in order Conclusion:The branch and leaves of Syringa Reticulata (Blume) Hara var. possess the strongest antibacterial activity,while its bark and flower possess a strong antioxidant activity. As a result, the branch and flower of the plant possess better application value.关键词：Syringa Reticulata (Blume) Hara var.;ethanol extraction;anti-bacterial;antioxidant;total phenols content
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发布时间：2022-08-31 - 摘要：This paper reviews the advance of experimental studies on the compatibility of single Chinese herbs containing aristolochic acid of its kidney detoxification function. We found that some medicines compatibility with the medicines containing aristolochic acid can decrease renal toxicity, including tonic herbs, hemorheologic agents, heat-clearing drugs, purgating drugs. These studies provide some reference for the clinical reasonable compatibility and security application of aristolochic acid in traditional Chinese medicine research.关键词：aristolochic acid;Caulis aristolochiae manshuriensis;Stephania tetrandra;toxicology of Chinese medicine;Chinese herb nephropathy;reduce toxicity;review
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发布时间：2022-08-31 - 摘要：This paper reviews the effective ingredients and the efficacy of antlers plate which can provide theoretical basis and reference for the application and development of the antlers plate and products. Its effective ingredients are protein, polypeptide, amino acid, mineral substances, polysaccharide, cholesterol, lipid, sex hormone and so on, with the antineoplastic, anti-inflammatory, antioxidant, antifatigue, antiviral, restraining hyperplasia of mammary glands, suppressing osteoporosis and anti-bacteria effects.关键词：antler plate;effective ingredient;efficacy assessment;review
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发布时间：2022-08-31
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