最新刊期
期 2 ， 2015
- 摘要：Objective: To observe the clinical efficacy of ascites cataplasm and western medicine for the treatment of ascites due to liver cirrhosis of the spleen and kidney yang deficiency pattern Methods: One hundred and eight cases with ascites due to liver cirrhosis of the spleen and kidney yang deficiency pattern were randomized into treatment group and control group, with 54 cases in each group. Treatment group was treated with ascites cataplasm and western medicine, and control group was treated with placebo cataplasm and western medicine, with the course of 14 days. The clinical efficacy, occurrence rate of adverse reactions were observed in both groups, and the TCM symptom scores and changes of clinical signs were compared between the groups Results: ① All the 107 cases were finished the trial, 54 in the treatment group and 53 in the control group. ② The total effective rate was 79.63% in the treatment group and 66.04% in the control group, with a difference between the two groups (P<0.05). ③ After treatment, there were significant difference in the TCM symptoms scores in each group (P＜0.05); with significant difference between the two groups, and treatment group was superior to the control group (P＜0.05). ④ In both groups, there were significant differences in the 24 h urine volume, abdominal circumference and body mass index between before and after treatment (P＜0.05); after treatment, there were significant differences in the above indexes between the two groups, and the treatment group was superior to the control group (P＜0.05). ⑤ No significant difference was found in occurrence rate of adverse reactions in both groups (P>0.05) Conclusion: Combined ascites cataplasm and western medicine has positive effect on ascites due to liver cirrhosis of spleen and kidney yang deficiency pattern by improving its clinical symptoms and signs.关键词：ascites due to liver cirrhosis;spleen and kidney yang deficiency pattern;ascites cataplasm;placebo control;clinical observation
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发布时间：2022-08-31 -
Combination of “Lidan Decoction” and western medicine for intrahepatic cholestasis in pregnant women
摘要：Objective: To observed the clinical efficacy of “Lidan Decoction” and western medicine in treating intrahepatic cholestasis during pregnancy Methods: Seventy-four pregnancy cases with intrahepatic cholestasis were randomized into treatment group and control group, with 37 cases in each group. Control group was treated the western medicine with liver protection effect orally, and treated group was treated with “Lidan Decoction” additionally, with the course of 14 days. The total bile acid, liver function (levels of TBIL, DBIL, IBIL, AST and ALT) and adverse pregnancy outcomes were observed Results: ① There were statistical differences in total bile acid, liver function (TBIL, DBIL, IBIL, AST and ALT) in both group between before and after treatment (P＜0.05). After treatment, there were statistical differences in total bile acid, liver function (TBIL, DBIL, IBIL, AST and ALT) between the two groups (P＜0.05). ②The adverse pregnancy outcome rate was 27.03% in the control group and was 10.81% in the treatment group, with a significant difference between the two groups (P＜0.05) Conclusion: Combined“Lidan Decoction” and western medicine can improve the liver damage and reduce the adverse outcome rate in pregnant women with intrahepatic cholestasis.关键词：intrahepatic cholestasis during pregnancy period;“Lidan Decoction”;total bile acid;liver function;adverse pregnancy outcome- 7
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发布时间：2022-08-31 - 摘要：Objective:To observe the clinical efficacy of “Lianfu Weihe Oral Solution” (LFWH) and triple therapy for the treatment of helicobacter pylori infection Methods: One hundred and eighty cases with helicobacter pylori infection were randomized into treatment A group, treatment B group, and control C group, with 60 cases in each group. Group C was treated with triple therapy (Omeprazole, amoxicillin and clarithromycin); group A was treated with normal dose of LFWH and triple therapy; group B was treated with high dose of LFWH and triple therapy, with the course of 7 days. The Hp eradication rate, clinical efficacy and adverse reactions were observed Results: ① Finally 172 cases fulfilled the trial, fifty-nine cases in group A, 57 in group B and 56 in group C. ② Full analysis set (FAS) showed that the Hp eradication rates of group A, B and C were 80%, 80.7% and 71.7% respectively; no significant difference was found among the groups (P＞0.05). Meanwhile, Protocol analysis set (PPS) showed that the Hp eradication rates of group A, B and C were 81.36%, 80.70% and 76.79% respectively; no significant difference was found among them (P＞0.05). ③ Full analysis set (FAS) showed that the clinical efficacy of the group A, B and C were 91.67%, 91.23% and 70.00% respectively; no significant difference was found among them (P＜0.05), but with significant difference between group A and C, and between group B and C (P＜0.05). PPS showed that the clinical efficiency of group A, B and C were 93.22%, 91.23% and 75.00% respectively; with significant difference among them (P＜0.05), as well as between group A and C, and between group B and C (P＜0.05). ④ Total of 21 cases of adverse reactions appeared in the trial, with 3 cases in the group A, 6 cases in the group B and 12 cases in the group C; with significant difference in occurrence rate of adverse reactions among them (P＜0.05), as well as between any two groups (P＜0.05) Conclusion: Combined LFWH and triple therapy can achieve satisfaction effects on the treatment of helicobacter pylori infection, and less adverse reactions. But high dose of “Lianfu Weihe Oral Solution” does not recommend.关键词：Helicobacter pylori;“Lianfu Weihe Oral Solution” (LFWH);triple therapy;eradication rate;adverse reaction
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发布时间：2022-08-31 - 摘要：Objective: To observe the effect of acupuncture and moxibustion therapy and cerebral therapeutic apparatus for cerebral hemiplegia Methods: Eighty cases were randomized into treatment group and control group, with 40 cases in each group. Based on the conventional therapy, treatment group was added with acupuncture and moxibustion therapy and cerebral therapeutic apparatus, and control group was added with routine acupuncture and moxibustion therapy, with 6 courses. The clinical efficacy and scores of neurologic impairment were observed Results: ① The total effective rate was 92.5% in the treatment group and 85.0% in the control group, and the clinical efficacy of the treatment group was better than that of the control group (P<0.05). ② The scores of neurologic impairment were reduced after treatment in both groups (P<0.05), and the score in the treatment group was less than that of the controls (P<0.05) Conclusion: Combined acupuncture and moxibustion therapy and therapeutic apparatus has good therapeutic effects on cerebral hemiplegia. It can improve the neurological function of patients markedly.关键词：cerebral infarction;rehabilitation;acupuncture and moxibustion therapy;therapeutic apparatus
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发布时间：2022-08-31 - 摘要：Objective: To observe the clinical efficacy of “Xinnaoning Capsules” in treating coronary heart disease of stagnation of heart blood pattern Methods: One hundred and twenty-six cases with coronary heart disease of stagnation of heart blood pattern were randomly divided into treatment group and control group by the ratio of 2∶1. Forty-two cases in the control group were treated with conventional therapy, and 84 cases in the treatment group were added with “Xinnaoning Capsules” orally, with the course of 8 weeks. The clinical efficacy and TCM symptom scores were observed Results: The effective rate of clinical efficacy and TCM symptoms were 90.5% and 91.7% respectively in the treatment group, and were 76.8% and 78.6% in the control group. There were significant differences in the clinical efficacy and TCM symptoms between the two groups (P<0.01) Conclusion: “Xinnaoning Capsules” can improve the clinical efficacy for the treatment of coronary heart disease of stagnation of heart blood pattern.关键词：stagnation of heart blood pattern;coronary heart disease;“Xinnaoning Capsules”
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发布时间：2022-08-31 - 摘要：Objective: To observe the clinical effect of Chinese medicine enema on serum beta-2 microglobulin (β2-MG) in patients with chronic kidney disease (CKD) at stage 3~4 Methods: Forty subjects with CKD3~4 were randomly divided into enema group and control group, with 20 subjects in each group. Control group was treated with conventional western medicine, and enema group was added with Chinese medicine, with the course of 10 weeks. The clinical efficacy and changes of Scr, BUN and β2-MG were observed before and after treatment in both groups Results: The total effective rate was 75.0% in the control group, and was 90.0% in the enema group; with significant difference between the two groups (P<0.05). After treatment, no significant difference was found in the levels of Scr, BUN and β2-MG in the control group (P>0.05); the levels of Scr, BUN and β2-MG in the enema group were decreased markedly (P<0.05), and the levels of the enema group was lower than that of the control group (P<0.05) Conclusion: Chinese medicine enema therapy can improve the clinical efficacy and lower the β2-MG level in patients with CDK3~4 stage.关键词：chronic kidney disease (CKD);Chinese medicine enema;beta-2 microglobulin (β;2;-MG)
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发布时间：2022-08-31 - 摘要：Objective: To observe the clinical efficacy of “Fufang Huoxue Liquids” (FFHXL) and mecobalamin treating diabetic peripheral neuropathy (DPN) Methods: Seventy cases with DPN were randomized into treatment group and control group, with 35 cases in each group. Treatment group was treated with FFHXL and Mecobalamin Tablets, and the control group was treated with Mecobalamin Tablets, with the course of 8 weeks. The clinical efficacy and changes of peripheral nerve conduction velocity were observed Results: The total effective rate was 88.24% in the treatment group and 45.71% in the control group; there was a significant difference in clinical efficacy between the two groups (P<0.05). After treatment, the conduction velocity of common peroneal nerve and sural nerve were accelerated (P<0.05, P<0.01), and the conduction velocity of sural nerve in the treatment group was faster than that of the control group (P<0.05) Conclusion: Combined FFHXL and Mecobalamin Tablets can improve clinical efficacy and peripheral nerve conduction velocity for DPN.关键词：diabetic peripheral neuropathy (DPN);“Fufang Huoxue Liquids” (FFHXL);mecobalamin;nerve conduction velocity
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发布时间：2022-08-31 - 摘要：Objective: To observe the clinical efficacy of “Xiaoying Mixture” in treating benign thyroid nodules Methods: One hundred cases with benign thyroid nodules were randomized into treatment group and control group, with 50 cases in each group. Control group was treated with “Neixiao Luoli Pills” orally, and treatment group was treated with “Xiaoying Mixture” orally, with the course of 3 months. The clinical efficacy, maximum diameters of thyroid nodules and TCM symptom scores were observed Results: ① The total effective rate was 80.00% in the treatment group and 60.00% in the control group, with a difference between the two groups (P<0.05). ② In both groups, there were significant differences in the maximum diameters of thyroid nodules between before and after treatment (P＜0.05); with significant differences between the two groups(P＜0.05). ③ In both groups, there were significant differences in TCM symptom scores between before and after treatment (P＜0.05); with significant difference value between the two groups (P＜0.05) Conclusion: “Xiaoying Mixture” is effective to shrink the thyroid nodules and improve clinical symptoms in patients with benign thyroid nodules.关键词：thyroid nodule;“Xiaoying Mixture”;“Neixiao Luoli Pills”;maximum diameter of thyroid nodule
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发布时间：2022-08-31 - 摘要：Objective: To discuss the assistant efficacy of “Yiqi Bushen Gutai Formual” with lymphocytes on outcome of embryonic re-transplantation Methods: Patients with unknown cause of plantation failure or embryonic re-transplantation after spontaneous abortion were selected by retrospective analysis. Patients accepted lymphocytes immunotherapy and Chinese medicine were classified into observation group, and who didn't take Chinese medicine or immunotherapies were classified into control group. The embryonic plantation, pregnancy and outcomes (abortion, teras, delivery) were observed Results: There were significant differences in embryonic plantation, pregnancy, abortion and delivery between the observation group and control group (P<0.05), but no significant difference was found in biochemical pregnancy, extrauterine pregnancy and teras between the two groups (P>0.05) Conclusion: “Yiqi Bushen Gutai Formual” can cooperate with lymphocytes immunotherapy to improve the outcome of embryonic re-transplantation.关键词：embryo transplantation;“Yiqi Bushen Gutai Formual”;lymphocytes active immunity;pregnancy outcome
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发布时间：2022-08-31 - 摘要：Objective: To observe the clinical efficacy of catgut embedment in acupoints and Chinese medicine for the treatment of polycystic ovarian syndrome (PCOS) Methods: Ninety cases with PCOS were randomized into treatment group and control group, with 45 cases in each group. Control group was treated with “Bushen Jianpi Huatan Formula”, and treatment group was added with catgut embedment in acupoints, with the course of 3 menstrual cycles. The clinical efficacy, related indicators in the serum (FPG, FINS, HOMA-IR and LP), body mass index (BMI) and waist-hip ratio (WHR) were detected and compared Results: ① Eighty-four cases finished the trial, with 41 cases in the treatment group and 43 cases in the control group. ② The total effective rate was 80.49% in the treatment group and 65.15% in the control group, with a difference between the two groups (P<0.05). ③ In both groups, there were significant differences in the levels of HOMA-IR, LP and WHR between before and after treatment (P<0.05); after treatment, there were significant differences in the levels HOMA-IR, LP and WHR between the two groups (P＜0.05) Conclusion: Combined catgut embedment in acupoints and Chinese medicine has positive effects on PCOS, and its mechanism may be association with lowering the serum leptin levels and reducing insulin resistance.关键词：polycystic ovarian syndrome (PCOS);insulin resistance;leptin;catgut embedment in acupoint;“Bushen Jianpi Huatan Formula”
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发布时间：2022-08-31 -
Effect of massage combined with conventional western treatment for children with rotavirus enteritis
摘要：Objective: To observe the effect of massage combined with conventional western treatment on children with rotavirus enteritis Methods: Seventy children with rotavirus enteritis were randomized into the treatment group (35 cases) and control group (35 cases). All the children were treated with montmorillonite powder and combined bacillus subtilis and enterococcus faecium granules with multivitamines, and took orally rehydration salt to prevent dehydration; children in the treatment group were treated with massage addtionally. After 3 days of treatment, the clinical effect was observed and the rotavirus enteritis in the stool was tested Results: The total clinical effective rates of treatment group and control group were 97.1% and 85.7% respectively, and the effect of the treatment group was better than that of the control group (P＜0.01). The rotavirus negative conversion rates of treatment group and control group were 45.7% and 14.3% respectively, and the rotavirus negative conversion rate of treatment group was higher than that of the control group (P＜0.01) Conclusion: The intervention of massage on the basis of conventional therapy in treating children with rotavirus enteritis can enhance the clinical efficiency and increase the rotavirus negative conversion rate.关键词：children rotavirus enteritis;integrective chinese and western medicine;massage- 7
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发布时间：2022-08-31 - 摘要：Objective: To observe the clinical efficacy of auricular acupuncture and low frequency electric acupuncture in preventing urine retention following postoperative mixed hemorrhoids Methods: Two hundred and forty subjects underwent haemorrhoidectomy were randomized into experimental group, control group and blank group, and respectively treated with auricular acupuncture and electric acupuncture, auricular acupuncture, and does not take any intervention. The occurrence rate of urine retention, first time urination after operation, urination after operation and related symptoms were observed of the three groups Results: ① The occurrence rate of urine retention was 2.5% in the experimental group, was lower than that of the blank group (26.25%), with significant difference between them (P<0.01). ② The first time urination after operation was shorter than that of the blank group and control group (P<0.05). ③ Scores of urination and scores of symptoms in lower abdomen of the experimental group were lower than those of the control group and blank group significantly (P<0.05). ④ VAS of 8h after surgery in the experimental group was lower than that of the blank group, with significant difference between them (P<0.05) Conclusion: Combined auricular acupuncture and low frequency electric acupuncture can reduce the occurrence rate of urine retention in postoperative mixed hemorrhoids, improve the clinical symptoms and relieve pain.关键词：urine retention;postoperative mixed hemorrhoids;prevention;auricular acupuncture;low frequency electric acupuncture
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发布时间：2022-08-31 - 摘要：This paper summarizes Prof. Wang Changqi's clinical experience in treating miscellaneous diseases. It views that morning stiffness can be treated by nourishing yin and blood, activating collaterals and softening tendons; reflux esophagitis can be treated by opening diaphragm and eliminating phlegm; hidrosis can be treated by nourishing heart qi and tonifying to constrain sweat; acne can be treated by clearing heat-toxicity, cooling blood to activity blood circulation; persistent erection of penis can be treated by nourishing kidney and softening hardness, nourishing yin to reduce fire; cholelithiasis can be treated by clearing heat to drain gallbladder, promoting qi and activating blood and collaterals; constipation can be treated by “Danggui Liuhuang Decoction”; chronic heart failure can be treated by restoring yang and rescuing patient from collapse, and replenishing qi and warming yan Methods:.关键词：miscellaneous diseases caused by internal injury;famous doctor's experience;Wang Changqi
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发布时间：2022-08-31 - 摘要：With the development of modern immunology, this paper discusses the theoretical basis for chronic hepatitis B by tonifying kidney method. It is believed that kidney deficiency is the key pathogenesis, which related to the immune system, especially the dysfunction of innate immunity. Tonifying kidney can eliminate the virus and protect the hepatocytes, so as to avoid liver cirrhosis and liver cancer in a long-term.关键词：chronic hepatitis B;kidney deficiency;tonifying kidney;immunology
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发布时间：2022-08-31 - 摘要：This paper expounds the psychological projection during mental homeopathy and its application during the treatment. It is believed that psychologic status can be analyzed by language, handwriting, interpersonal relations and attitude etc. So the proper therapeutic method can be applied to improve the intervention effect.关键词：TCM psychology;emotional depression;mental homeopathy;projection
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发布时间：2022-08-31 - 摘要：Objective: To discuss the correlation between TCM patterns of chronic glomerulonephritis and immunological parameters including T-lymphocyte subsets, immunoglobulin and complement, and to provide an Objective: basis for TCM differentiation of chronic glomerulonephritis Methods: One hundred and twenty cases with chronic nephritis as the evaluation objects, with 40 cases of healthy people as the control group. T lymphocyte subsets, immunoglobulin and complement were detected, and correlation between the two groups according to TCM patterns was analyzed Results: Compared with the healthy group, the levels of IgA, IgG, C3, CD3+, CD4+ and CD4+/CD8+ were reduced in the chronic glomerulonephritis group, but the CD8+ level was increased (P<0.05, P<0.01); IgA, IgG, CD3+, CD4+ and CD4+/CD8+ levels of patients with chronic glomerulonephritis is the lowest in the pattern of yang deficiency of spleen and kidney, followed by the pattern of qi deficiency of spleen and kidney, and the highest in the pattern of yin deficiency of liver and kidney. C3 level is the lowest in the pattern of qi deficiency of lung and kidney. CD8+ level is the lowest in the pattern of yin deficiency of liver and kidney, and the highest in the pattern of yang deficiency of spleen and kidney. These difference showed statistically significant (P<0.05, P<0.01).Conclusion There has relationship among T lymphocyte subsets, immunoglobulin, complement and chronic glomerulonephritis. There is a clear correlation between TCM patterns and immunological parameters. Our sampl Results: that patients with chronic nephritis have an imbalance of yin and yang, which may be associate with the immune dysfunction.关键词：chronic nephritis;T-lymphocyte subset;immunoglobulin;complement;TCM pattern
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发布时间：2022-08-31 - 摘要：Objective: To observe the TCM syndrome distribution and clinical characteristics of late onset hypogonadism Methods: Four hundred and sixty-one cases with late onset hypogonadism (LOH) were divided into TCM syndrome types. The scales of AMS were surveyed and the total testosterone (TT) levels in serum were detected Results: Among the 461 patients, the deficiency of liver yin and kidney yin (34.49%) were the main two TCM syndrome types of LOH. The rest of them are deficiency of kidney yang type, kidney deficiency and liver depression type, deficiency of heart and spleen type, etc. Symptom scores of angiokinesis in deficiency of liver yin and kidney yin type was higher than those of the other types, while symptom scores of physical ability was lower than those of the other types (P＜0.05); scores of sexual function in deficiency of kidney yang type was higher than those of the other types, but the symptom scores of angiokinesis was lower than those of the other types (P＜0.05); symptom scores of mental-psychological in kidney deficiency and liver depression type was higher that those of the other types(P＜0.05). The testosterone (TT) levels in serum of the deficiency of kidney yang type and deficiency of heart and spleen type were lower than those of the deficiency of liver yin and kidney yin type and kidney deficiency and liver depression type (P＜0.05) Conclusion: The deficiency of liver yin and kidney yin and deficiency of kidney yang type are the main types of LOH. There are significant differences in clinical efficacy and TT level among TCM syndrome types.关键词：late onset hypogonadism (LOH);TCM syndrome;epidemiology
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发布时间：2022-08-31 - 摘要：This paper introduces Professor Peng Peichu's experience in treating chronic prostatitis. It is viewed that chronic prostatitis is a syndrome of intermingled deficiency and excess, coexisted cold and heat. Pathogenesis of chronic prostatitis is stagnation leading to pain and its therapeutic principle is obstruction-removing method. Combined reinforcement with elimination and combined use of cold with hot herbs are the basic therapeuti Methods:. One proven case is presented.关键词：chronic prostatitis;obstruction-removing therapy;famous doctor's experience;Peng Peichu
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发布时间：2022-08-31 - 摘要：This paper introduces Prof. Xuan's clinical experience in differentiating and treating Tourette's disease in children. Syndrome differentiation focusing on wind evil, and indigestion, phlegm and blood stasis are complicated. We believe that indigestion is one of the pathogenic factors and is the main cause of Tourette's disease. Extinguishing wind to dredge collaterals, soothing liver to relieve spasm, regulating heart, spleen and kidney should be paid attention to during the treatment.关键词：Tourette's disease in children;famous doctor's experience;Xuan Guiqi
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发布时间：2022-08-31 - 关键词：kidney disease;IgA nephropathy;allergic purpura nephritis;“Mahuang Lianqiao Chixiaodou Decoction”
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发布时间：2022-08-31 - 摘要：This paper analyzes ancient physician Xu Shuwei's academic thoughts based on “Syndrome of Pearl Pills” in Effective Prescriptions for Universal Relief, according to Peaceful Holy Benevolent Prescriptions and Prescriptions from the Great Peace Imperial Grace Pharmacy. The categories, narration, pathogenesis of “Syndrome of Pearl Pills” are analyzed. We concluded that research on “Syndrome of Pearl Pills” has significance for the evolution and development of theory, therapeutic principle, and prescription of liver diseases.关键词：Effective Prescriptions for Universal Relief;“Syndrome of Pearl Pills”;classification;theoretical innovation
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发布时间：2022-08-31 - 关键词：refractory infertility;Chinese medicine;famous doctors experience;Qi Cong
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发布时间：2022-08-31 - 关键词：nonalcoholic fatty liver disease;Chinese medicine;stage differentiation
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发布时间：2022-08-31 - 摘要：This paper summarizes the origin, compatibility character of “Six-ingredient Xiaoqinglong Decoction” in Xu's pediatrics. Indications of this formula include cold cough and pneumonia.关键词：“Six-ingredient Xiaoqinglong Decoction”;Xu's pediatrics;phlegm and fluid obstructed in lung;Ephedrae Herba
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发布时间：2022-08-31 - 摘要：Objective:To investigate the role of cyclic mechanical stretch on IL-1β-induced MMPs mRNA expression in synovioblasts of human knee joints Methods:The fourth-generation synovioblasts of human knee joints were seeded onto type Ⅰ collagen-coated BioFlex 6-well culture plate at density of 4×105/well, the following three different treatment groups were devised:normal group (untreated with IL-1β or cycle stretch), control group (treated with 10ng/ml IL-1β only), stretch group (treated with 10ng/ml IL-1β and subjected to cyclic mechanical stretch at a magnitude of 0-12%, frequency of 1Hz, and time of 60 min per day). After being stretched for 3 days by Flexcell-5000 tension system, RNA was extracted and RT-PCR was performed to detect the MMP1/3/13 mRNA level Results:Compared with the blank group, expressions of MMP1/3/13 mRNA in the control group were significantly increased (P<0.05); compared with the control group, expressions of MMP1/13 mRNA in the stretch group were decreased markedly (P<0.05), while he descend range of MMP3 mRNA was not obviously (P>0.05) Conclusion:Cyclic mechanical stretch (at a magnitude of 0-12%, frequency of 1Hz, and time of 60 min per day) may inhibit the MMP1/13 mRNA expression in synovioblasts of human knee joints, which may have the potential to protect cartilage damage induced by synovial inflammation.关键词：synovioblast;cell culture;cyclic mechanical stretch;matrix metalloproteinase
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发布时间：2022-08-31 - 摘要：Objective: To observe the effects of different doses of “Qingzhi Hugan Prescription” on the expressions of Src family kinase (Hck, Lyn, Fgr) and Src-suppressed C kinase substrate in liver tissues of rats with nonalcoholic fatty liver disease, and to investigate its mechanism on NAFLD Methods: Fifty-eight SD rats of two months were classified into normal group, except the normal group, others were feed with high-fat (80.5% ordinary fodder, 2% cholesterol, 12% lard, 5% egg yolk powder, 0.5% sodium cholic acid) for 8 weeks and the models were established. The models were randomized into model group, “Qingzhi Hugan Prescription” groups (large, medium and small dose). “Qingzhi Hugan Prescription”groups were gavaged with decotions, and the model group ang normal group was gavaged with 0.9% NaCl solution. After the experiment, the expressions of Hck, Lyn, Fgr and SSeCKS of the liver tissues were detected by immunohistochemistry Results: Compared with model group, whatever the large, medium and small dose of the Chinese medicine groups, especially the large dose of “Qingzhi Hugan Prescription” group, the positive expressions of Hck and Lyn were decreased markedly (P＜0.01); compared with the normal group, the expression of SSeCKS in the model group was decreased markedly; in the Chinese medicine groups, the SSeCKS were expressed between the model group and normal group; It showed a trend of decrease along with the rise of the expressions of Lyn and Hck in the rat liver tissue with nonalcoholic fatty liver disease;Compared with model group, effect of “Qingzhi Hugan Prescription” on the expression of Fgr was insignificant (P>0.05) Conclusion: Expressions of SSeCKS, Lyn and Hck were regulated by “Qingzhi Hugan Prescription”, which reduced inflammation of the liver. It can be used as one of the mechanisms for the treatment of NAFLD.关键词：“Qingzhi Hugan Prescription”;non-alcohlic fatty liver disease(NAFLD);rat
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发布时间：2022-08-31 - 摘要：Objective: To observe the effect of Chinese herbs with tonifying kidney and replenishing qi actions on the adenosine content and the protein expression of the ATP synthase β aging rats' skeletal muscles Methods: Thirty-two SD rats were randomized into four groups:normal group, model group, Chinese medicine group and methandienone group. Except the normal group, rats in the other groups were received subcutaneous injection of 10% D-galactose solution (100 mg·kg-1, once a day) for 10 weeks to make the aging models. After 10 weeks of intervention with Chinese herbs and methandienone, the contents of ATP,ADP and AMP in each group were detected by high performance liquid chromatography (HPLC) - UV method to calculate energy charge (EC) value; the protein expression of the ATP synthase beta in skeletal muscles were detected by Western blotting Results: Compared with the nomal group, the ATP content and EC value of skeletal muscles in the model group were decreased, and the AMP content was rised, and the protein expression of the ATP synthase beta was decreased significantly (P<0.05); compared with the model group, the ADP content in Chinese medicine group was declined, and the EC value was rised significantly; the ATP content and EC value in the methandienone group was rised significantly than those of the DC group; the protein expression of the ATP synthase beta was rised significantly in the Chinese medicine group and methandienone group (P<0.05). Compared with the methandienone group, the ADP content in the Chinese medicine group was reduced significantly (P<0.01) Conclusion: Chinese herbs with tonifying kidney and replenishing qi actions can improve the protein expression of the ATP synthase β, improve energy metabolism of skeletal muscles and retard the aging process of body and skeletal muscles by enhancing ATP content and EC value.关键词：Chinese herbs with tonifying kidney and replenishing qi actions;aging;skeletal muscle;ATP synthase
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发布时间：2022-08-31 - 摘要：Objective:To investigate the effect of extract of Juglans mandshurica maxim on apoptosis of endothelial cells induced by endogenous H2O2 in vitro Methods:Endothelial cells induced by endogenous H2O2 cells were cultured by incubating with 10 mU GOX. ① Cells were divided into the blank control group, 10 mU GOX group, and experimental groups by different concentrations (10 mU GOX and 25 mg/L, 50 mg/L, 100 mg/L extract). Each group was treated with the corresponding measures. The effect of Juglans mandshurica maxim on morphology and proliferation of vascular endothelial cells were detected. ② Cells were divided into the blank control group, 10 mU GOX group and 10 mU GOX+50 mg/ L extract group, and each group was treated with the corresponding measurements. The apoptotic cells were detected by Hoechst 33258 Assay Kit, and apoptotic percent was measured by flow cytometry (FCM) after Annexin / PI double staining Results: ① Compared with the blank control group, there were significant differences in the cell survival rate in the 10 mU GOX group, 10 mU GOX+25 mg/L, 50 mg/L and 100 mg/L groups (P＜0.05, P＜0.01). The cell survival rates in the 10 mU GOX+25 mg/L, 50 mg/L and 100 mg/L groups were higher than that of the 10 mU GOX group (P＜0.05, P＜0.01). Results: of Hoechst33258 fluorescence staining showed that:compared with the blank control group, apoptosis rate in the 10 mU GOX group was increased significantly (P<0.01); compared with the 10 mU GOX group, apoptosis rate in the 10 mU GOX+50 mg/L group was increased markedly (P<0.01) Conclusion:The extract of Juglans mandshurica maxim can protect the cells significantly, which indicate that it has inhibiting effect on cell apoptosis induced by endogenous H2O2.
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发布时间：2022-08-31 - 摘要：Objective: To study the hypoxia tolerance and anti-fatigue of “Mai Wei Shen” in mice and to provide the basis for further development and application Methods: ① Hypoxia tolerance experiment:Two hundred and forty SPF male mice were randomly divided into four groups:normal saline group, “Sheng Mai Yin” groups (high, medium and low dose), with 60 mice in each group; each group was treated with the corresponding measurements. The survival times in hypoxia tolerance test, after sodium nitrite poisoning and in acute cerebral hypoxia, the content of cyanide high-speed rail hemoglobin, and the contents of SOD, GPX and MDA were detected after 30 days. ② Anti-fatigue experiment:Forty-eight SPF male mice were randomly divided into four groups:normal saline group and “Sheng Mai Yin” groups (high, medium and low dose), with 12 mice in each group; each group was treated with the corresponding measurements. The contents of BLA, BUN, hepatic glycogen, muscle glycogen and exhaustive swimming time of mice after exercise were determined by weight loading swimming experiment Results: ① Hypoxia tolerance experiment:Compared with the normal saline group, “Mai Wei Shen” could markedly prolong the survival time in hypoxia tolerance test, survival time after sodium nitrite poisoning and the survival time in acute cerebral hypoxia, and reduce the content of cyanide high-speed rail hemoglobin and contents of MDA, increase the activity of SOD and GPX markedly (P<0.05). ② anti-fatigue experiment:Compared with the normal saline group, “Mai Wei Shen” could prolong the exhaustive swimming time, increase the contents of hepatic glycogen and muscle glycogen, and reduce the concentration of serum BLA and BUN (P<0.05) Conclusion: “Mai Wei Shen” has the certain effect on increase of hypoxia tolerance and relieving fatigue.
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发布时间：2022-08-31 - 摘要：Objective:To separate chemical indicator and establish a HPLC method for determining the indicator in herbs from Dendrobii Officialis Caulis Methods:The constituents were separated and purified by column chromatography on silica gel and Sephadex LH-20, as well as the chemical structures were determined by spectral data analyses. Determination of content of 3,4-dihydroxy-5,4’-dimethoxy bibenzyl (DDB-1) was performed by using high performance liquid chromatography. A Phenomenex-C18 column (250 mm × 4.60 mm, 5 μm) was adopted with a mobile phase of acetonitrile-water, the runs were set at 230 nm Results:Four stilbenoids compounds were isolated and identified as 3,4-dihydroxy-5,4’-dimethoxybibenzyl, 3,4-dihydroxy-5-methoxybibenzyl, 5-hydroxy-3,4’-dimethoxybibenzyl, 4’-hydroxy-3’, 5’- dimethoxybibenzyl. DDB-1 was selected as an indicator to assess the quality of Dendrobii Officialis Caulis. This indicator showed a good linear relationship within the range of 0.044 ~ 0.44 μg (R2=0.999 9). The determination of DDB-1 in tested samples from different production base was most different, and it had little difference between each other if Dendrobii Officialis Caulis harvested in different month Conclusion:This proposed method was found to be accurate, reliable and simple, providing rapid and special determination of DDB-1, which could be used to control quality of Dendrobii Officialis Caulis.关键词：Dendrobii Officialis Caulis;determination;3,4-dihydroxy-5,4’-dimethoxy bibenzyl;HPLC
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发布时间：2022-08-31 - 摘要：This article summarizes the research progress on the correlation between coronary heart disease (CHD) of blood stasis pattern and coronary artery lesions form the aspects of blood physicochemical indexes and molecular genetics levels. It finds that some researches have been achieved in blood physicochemical indexes and molecular genetics levels. CHD of blood stasis pattern do have certain correlation with coronary artery lesions.
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发布时间：2022-08-31 - 摘要：This paper reviews the research progress on effect of Epimedii Folium on osteoblasts and osteoclasts in recent years. It is found that Epimedii Folium can increase the concentration of Ca2+, activate signal pathway of BMP/Smad and Wnt/β-catenin, and promote the proliferation and differentiation of cells by increasing the expression of correlation factors of osteoblasts. Epimedii Folium can enhance the function and form of osteoblasts and inhibit proliferation and absorptive action of osteoclasts.关键词：Epimedii Folium;osteoblast;osteoclast;review
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发布时间：2022-08-31
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