最新刊期
期 12 ， 2015
- 摘要：Objective:To observe the clinical efficacy of “Golden Plaster” in treatment of knee osteoarthritis. Methods80 patients with knee osteoarthritis were randomly divided into experimental group and control group, 40 in each group. Patients in treatment group were treated with “Golden Plaster” while the control group was treated with placebo. The courses for the two groups were 21 days. VAS score, modified JOA score and TCM syndrome integral were observed. Results:① During the experiment, 2 cases in the experiment group were shed and there was no shedding case in control group, 78 cases completed the experiment. ② Compared in the group before and after the experiment, there was statistically significant difference in VAS score, modified JOA score and TCM syndrome integral(P<0.05). Compared between the two groups before and after the experiment, there was statistically significant difference in VAS score, modified JOA score and TCM syndrome integral(P<0.05). Conclusion:“Golden Plaster” can effectively alleviate patients' knee pain, and improve the activity ability of the joints and quality of lives.关键词：knee osteoarthritis;“Golden Plaster”;placebo control;non-operative treatment
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发布时间：2022-08-31 - 摘要：Objective:To observe the clinical efficacy of “Qishen Erlian Decoction” combined with Entecavir on patients with chronic hepatitis B. Methods62 patients with chronic hepatitis B were randomly divided into control group (30 cases) and treatment group (32 cases), in which the control group received Entecavir tablets while the treatment group received “Qishen Erlian Decoction” on the basis of Entecavir tablets. Two groups of patients with a course of 1 year and were followed up for 6 Months. We observed the virological responses, e antigen conversion rates, liver function(ALT, AST, TBIL) and IL4, IFN-γlevels. Results:①The EVR of the two groups was 68.75% and 33.33%, ETVR was 78.13% and 50%, SVR was 71.88% and 36.67%, the difference was statistically significant (P<0.05); ②Compared between the two groups after the treatment and 6 months follow-up, difference was statistically significant on the e antigen conversion rate (P<0.05); ③Comparison with pre-treatment, difference were statistically significant in AST, ALT, TBIL levels of both groups (P<0.05), between the two groups after treatment, AST, ALT, TBIL levels had no significant difference (P>0.05); ④Comparison with pre-treatment, difference were statistically significant in IL-4, IFN-γ levels of both groups (P<0.05), between the two groups after the treatment, IL-4, IFN-γ levels were significantly (P<0.05 ); between the two groups at follow-up to 6 months, IL-4, IFN-γ levels were significantly (P<0.05). Conclusion:The clinical effect of “Qishen Erlian Decoction” combined with Entecaviris on patients with chronic hepatitis B was significant, not only can significantly inhibit the replication of HBV-DNA, but also regulate IL4 and IFN-γ levels, thereby enhancing the body's ability to clear the virus, promoting e antigen conversion.关键词：“Qishen Erlian Decoction”;chronic hepatitis B;virological responses;IL-4;IFN-γ
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发布时间：2022-08-31 - 摘要：Objective:To evaluate clinical effects and prognosis of “Qingxia Huayu Decoction” combined with Western Medicine on AP treatment； Methods65 cases of acute pancreatitis patients were divided into treatment group (32 cases ) and control group (33 cases). Patients in the control group took western medicine treatment, and the treatment group took “Qingxia Huayu Decoction” on the basis of the treatment of the control group for 7 days, respectively. CT score and CRP, calcium,the complication rate were analyzed, The clinical effects of these two groups would be evaluated. Results:① The clinical study showed that the total effective rate of the treatment and control groups were 96.88％ and 84.85% respectively; there was significant difference in the clinical efficacy between the two groups(P<0.05). ②There was significant difference in the level of CRP and Ca2+ between the two groups after the treatment(P<0.05). ③There was significant difference in the CT score between the two groups after the treatment(P<0.05). ④There was significant difference in the complication rate in the two groups(P<0.05). Conclusion:There are well clinical and synergies of “Qingxia Huayu Decoction” combined with western medicine on SAP, and it play a good role to improve the prognosis of severe acute pancreatitis.关键词：Acute Pancreatitis;“Qingxia Huayu Decoction”;integrated traditional Chinese and western;inflammatory response;complication
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发布时间：2022-08-31 - 摘要：Objective:To observe the clinical efficacy of “Compound Danshen Dripping Pills” and Amlodipine Tablets in the treatment of primary hypertension with positive electrocardiogram treadmill exercise tests. MethodsOne hundred and forty-six subjects were randomized into two groups:control group in which in which 66 cases were treated with Amlodipine Tablets, and treatment group in which 80 cases were treated with Amlodipine Tablets and “Compound Danshen Dripping Pills”, with a course of four weeks. The electrocardiogram efficacy, peak systolic pressure and the indexes of electrocardiogram treadmill exercise tests were observed. Results:① The total effective rate for electrocardiogram was 96.25% in the treatment group and 83.33% in the control group, with better efficacy in the treatment group than in the control group(P<0.05). ②After treatment, the peak systolic pressures were reduced in both groups(P<0.05), with lower pressure in the treatment group than in the control group(P<0.05). ③After treatment, the indexes of electrocardiogram treadmill exercise tests were improved in both groups(P<0.05), with more significant improvement in the treatment group than in the control group(P<0.05). Conclusion:Combined “Compound Danshen Dripping Pills” and Amlodipine Tablets is effective for hypertension and heart protection.关键词：hypertension;electrocardiogram treadmill exercise test;Compound Danshen Dripping Pills
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发布时间：2022-08-31 - 摘要：Objective:To observe the clinical efficacy of acupuncture and Risperidone in the treatment of post-stroke hallucinosis. MethodsNinety-eight subjects were randomized into two groups:control group in which 49 cases were orally given Risperidone, and treatment group in which 49 cases were given acupuncture and oral Risperidone, with a course of three weeks. Results:The total effective rate was 97.96% in the treatment group and 87.76% in the control group, with better effects in the treatment group than in the control group(P<0.05). After treatment, the scores of such symptoms of life quality as somatization were reduced in both groups(P<0.05, P<0.01), with lower scores in the treatment group than in the control group(P<0.05). After treatment, the cognitive and memory scores were obviously increased in both groups(P<0.05), with higher score in the treatment group than in the control group(P<0.05). The contents of plasma 5-HT were significantly increased after treatment in both groups(P<0.05), with higher content in the treatment group than in the control group(P<0.05). Conclusion:In the treatment of post-stroke hallucinosis, acupuncture with Risperidone can effectively improve clinical symptoms and life quality possibly by promoting the release of plasma 5-HT.关键词：stroke;hallucinosis;acupuncture therapy;5-HT
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发布时间：2022-08-31 - 摘要：Objective:To study the clinical effects of “Bushen Jianpi Zhixue Decoction” in the prevention of thrombocytopenia after demethylation of myelodysplastic syndrome. MethodsThirty-nine subjects were randomized into two groups:control group in which 18 cases were treated with Decitabine Injection, and treatment group in which 21 cases were treated with Decitabine Injection and “Bushen Jianpi Zhixue Decoction”. After 15 days, the bleeding condition, platelet indexes and the contents of serum IL-11 were observed in both groups. Results:①The bleeding rate was 42.86% in the treatment group and 66.67% in the control group, with lower rate in the treatment group than in the control group(P<0.05). ②After treatment, the blood platelet count(PLT), plateletcrit(PTC) and platelet volume distribution width(PDW) were increased (P<0.05) and the platelet volume(MPV) reduced(P<0.05) in both groups; there were significant differences in PLT and PDW between the two groups(P<0.05). ③The contents of serum IL-11 were of no difference between before and after treatment in the two groups and between the two groups(P>0.05). Conclusion:“Bushen Jianpi Zhixue Decoction” can prevent thrombocytopenia after demethylation of myelodysplastic syndrome and reduce hemorrhage.关键词：myelodysplastic syndrome;“Bushen Jianpi Zhixue Decoction”;thrombocytopenia
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发布时间：2022-08-31 - 摘要：Objective:To observe and assess the efficacy of mild moxibustion of Zi Wu Liu Zhu Time Rule(ZWLZ) combined with umbilical therapy in preventing gastrointestinal reactions caused by cancer chemotherapy. Methods120 gastrointestinal tract tumor patients with chemotherapy was selected and randomly divided into experimental group and control group,60 cases in each group. During chemotherapy period,conventional acid suppression and anti-nausea treatment were used in both groups,the mild moxibustion and dressing umbilicus of drug base on select time were used in the experimental group,and the conventional treatment time were used in control group. The effective rate of gastrointestinal reaction and severity of symptom in two groups was observed and compared. Results:The incidence of untoward effect of gastric area in experimental and control group were respectively 51.7% and 80.0% in chemotherapeutic period and the untoward effect of gastric area in experimental group were significantly lower than that of control group(P<0.05). Conclusion:The therapy of mild moxibustion of Zi Wu Liu Zhu Time Rule combined with umbilical therapy is effective in preventing gastrointestinal reactions caused by cancer chemotherapy. It can significantly reduce the incidence of nausea,vomiting and poor appetite after chemotherapy.关键词：gastrointestinal tract tumor;chemotherapy;Nausea;vomiting;Zi Wu Liu Zhu Time Rule(ZWLZ);moxibustion therapy
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发布时间：2022-08-31 - 摘要：Objective:To observe the clinical effect of clearing heat and resolving stasis method in the treatment of adenomyosis with blood stasis syndrome. Methods60 patients (blood stasis syndrome) were randomly divided into treatment group and control group, 30 cases in each group. The treatment group was given clearing heat and resolving stasis prescription while the control group was treated with Xue Fu Zhu Yu capsule. Both groups were medicated for 3 months in succession. The degree of dysmenorrhea, the change in menstruation cycle, blood CA125 and uterine volume were observed after treatment. Results:①The total efficacy rate in the improvement of menstrual cycle was 90.00% in the treatment group and 66.67% in the control group. There had statistical difference between the groups (P<0.05). ②Both groups had significant difference in relieving dysmenorrheal (P<0.05), and there had significantly difference between the two group s (P<0.05). ③Serum CA125 levels were significantly decreased in both groups after the treatment(P<0.05), but the two groups did not differ significantly(P>0.05). ④Both groups had significant difference in controlling uterus volume(P<0.05), and there had significantly difference between the two groups (P<0.05). Conclusion:Clearing heat and resolving stasis method could effectively improve the clinical symptoms of adenomyosis patients with blood stasis syndrome.关键词：adenomyosis;blood stasis syndrome;Clearing Heat and Resolving Stasis Therapy;Shi Xiao San;dysmenorrhea degree;uterus volume
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发布时间：2022-08-31 - 摘要：Objective:To retrospectively analyze the effect of recurrent respiratory infection(RRI) on curative effect of “Qufeng Zhidong Decoction” in the treatment of tic disorders in children. MethodsTwo hundred and seventy-three subjects RRI group and non-RRI group, and treated with “Qufeng Zhidong Decoction” for 9 months. The clinical efficacy, YGTSS score and recurrence rate were observed. Results:①The total effective rate was higher in the non-RRI group than in the RRI group(P<0.05); ②The YGTSS score was lower in the non-RRI group than in the RRI group(P<0.05); ③The recurrence rate was 43.41% in the RRI group, higher than 18.68% in the non-RRI group(P<0.01). Conclusion:Recurrent respiratory infection has a significant effect on the treatment TD and increases its recurrence rate.关键词：tic disorder;recurrent respiratory infection;“Qufeng Zhidong Decoction”;retrospective analysis
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发布时间：2022-08-31 - 摘要：This paper introduces Professor Liu Ping’s experience in treating primary biliary cirrhosis. Professor Liu advocates that the basic TCM pathogenesis of this disease is Qi and Yin deficiency and stasis and heat inside; as to the treatment, the principle therapy is tonifying Qi and nourishing Yin:pay attention to nourishing spleen in tonifying Qi, due consideration to liver and kidney in nourishing Yin. Considering the accompanied pathogenesis of stagnant heat, we can impose different way to treatment like heat-clearing, removing blood stasis and soft firm. A proven case was listed in this paper.关键词：primary biliary cirrhosis;tonifying Qi and nourishing Yin;heat clearing and blood stasis removing;deficiency of essential Qi;damage of body shaping and body quality;experience of famous doctors
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发布时间：2022-08-31 - 摘要：Not only hypochondriac pain and stomachache, but also cardiodynia,pectoralgia,abdominal pain,osphyalgia,ophthalmalgia,and even pantalgia can all be induced by depression. Apart from the stagnation of liver-qi,and stagnated qi transforming into fire,the pathogenesis of pain can also be connected to the dysfunction of heart,spleen,and kidney which was injured by bad emotion. The severity of pain is related to the activity of heart. Modern medicine proved that pain,psychological factors and pathophysiologic bases are cause-and-effect each other. Pain can be the somatic symptoms of depression. The clinical features of pain due to depression syndrome includes the fluctuation of emotion induced by pain; it possess the characteristics of functionality, variety, universality, relapsing, and peculiarity; it also manifests “the uncertain pain”; and it can be relieved after the antidepressant therapy. The pathogenesis of pain due to depression syndrome includes but not limits to the “pain induced by qi and blood stasis” as well as “pain induced by qi and blood without nourishment”. Treating from the aspect of depression can be considered in the pain treatment.关键词：depression syndrome;pain;treating from the aspect of depression;psychology
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发布时间：2022-08-31 - 摘要：Based on the existing research literatures on the ovarian cancer and its relationship with Chinese medicine constitutions,an intermediary mechanism model was built to describe how Chinese medicine constitutions affect on ovarian cancer through the micro factors. The possible affection path sets can be researched with this model,which helps to provide new analysis perspective on studying the relationship between Chinese medicine constitutions and ovarian cancer.关键词：Chinese medicine constitution;ovarian cancer;micro factors;intermediary mechanism
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发布时间：2022-08-31 - 摘要：Objective:To analyze the law of traditional Chinese medicine(TCM)syndrome differentiation and medication on polycystic ovary syndrome based in perspective of literature research, hereby to provide reference for clinical practice. MethodsThe clinical research literature on TCM for polycystic ovary syndrome from January 2000 to January 2015 was searched in China National Knowledge Infrastructure(CNKI). A database of TCM for polycystic ovary syndrome was established. The frequency of medication was analyzed. The effect,nature,flavor and channel entry of herbs were descriptively analyzed. Results:①40 articles were included in the research, during which 1790 cases, 7 syndrome types, 6 syndrome factors, 53 prescriptions and 99 core prescription drugs were included, and 640 herb frequency involved. ②The top 3 syndrome types were deficiency of kidney and blood stasis type, deficiency of kidney and sputum dampness type, phlegm and blood stasis intrinsic type. The top 3 syndrome factors were deficiency of the kidney,blood stasis,phlegm obstruction. ③The 99 herbs could be divided into 8 categories according to the effect. The top 3 were deficiency-supplementing herb,blood-quickening stasis-transforming herb and dampness-removing phlegm-reducing herb. ④There were 30 herbs with a frequency greater than 8, and the top 5 were Danggui,Shudi, Xiangfu,Tusizi and Fuling. ⑤In the frequency of herb nature,the top 3 were warm,cold and calm. In the frequency of herb flavor,the top 3 were sweet,bitter and pungent. In the frequency of meridian tropism, the top 3 were liver, kidney and spleen. Conclusion:Traditional Chinese medicine syndrome differentiation and medication on polycystic ovary syndrome pay attention to the combination of supporting the healthy energy and eliminating the evil factors, promoting blood circulation to remove blood stasis and dampness-removing phlegm-reducing are often used in treating polycystic ovary syndrome on the base of tonifying kidney and regulating menstrual cycle.关键词：polycystic ovary syndrome;TCM therapy;syndromes and treatment;medication law;literature research.
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发布时间：2022-08-31 - 关键词：functional abdominal pain;psychosomatic diseases;teaching ward round
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发布时间：2022-08-31 - 摘要：This article introduces the clinical experience of Professor Huang Jigeng, who is a famous doctor of traditional chinese medicine(TCM), on treating phlegm cough from lung, spleen and kidney of TCM. Professor Huang thought that the insidious phlegm in the lungs and the dysfunction of lung, spleen and kidney are the primary pathogensis of respiratory diseases. On the basis of summarizing the theories of predecessors, Professor Huang innovated to use his distinctive theories through all the procedures of the treatments based on syndrome differentiation.关键词：phlegm cough;famous doctor’s experience;Huang Jigeng
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发布时间：2022-08-31 - 摘要：This paper introduces Professor Caigan’s clinical experience in treating geriatric diseases with ointment. Professor Cai thinks that geriatric diseases were intermingled with excess and deficiency syndromes, and syndromes of phlegm and blood stasis interpentrated. In clinic practice , he pay more attention to acquired factors,and taking into account the innate in clinic. Hid Characteristics of clinical medication is clear light and smart,qi and blood were regulating together,static and dynamic integrated,benefiting and dispel evil contrast and complement each other. A proven case was listed.关键词：geriatric diseases;ointment;famous doctor’s experience;Cai Gan
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发布时间：2022-08-31 - 摘要：This article introduces the experience of Major Bupleurum Decoction for the treatment of Obstinate Insomnia. The major pathogenesis is related with liver-fire excess and stagnation of heat in spleen and stomach,while the decoction has the efficacy of soothing liver,regulating stomach,purging heat and clearing obstruction. The adaptable indication was provided and a proven case was listed.关键词：obstinate insomnia;Major Bupleurum Decoction;clinical experience
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发布时间：2022-08-31 - 摘要：In this paper we discussed the etiology and pathogenesis of idiopathic epilepsy, and put forward differentiation and treatment on the theory of “Fu Qi”. We thought that there was relationship between the etiology and pathogenesis of idiopathic epilepsy and Fuxie. In attack stage, soothing liver regulating qi, expelling phlegm and resurrecting were the primary method for this disease, and in remission stage we should pay more attention to promote the body resistance and eliminate pathogenic factors. It is important to stabilize the unattached areas in case of spread and worsen.
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发布时间：2022-08-31 - 摘要：This paper analyzed when and how to eliminate evil depends on pathogen location and stage in Synopsis of Prescriptions of Golden Chamber. If evil has outgoing tendency, measures should be taken to help it out. Eliminating evil should be given judicious guidance according to circumstances.关键词：Synopsis of Prescriptions of Golden Chamber;to give judicious guidance according to circumstances;eliminating evil
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发布时间：2022-08-31 - 摘要：Though discussing the relationship between liver and chronic pelvic inflammatory disease,this paper proposed a point that differentiation and treatment of chronic pelvic inflammatory disease from the liver. We thought that soothing liver and nourishing liver was the core in treatment,and should adopt the method of circulating qi and blood and eliminating dampness and heat of according different stages.关键词：chronic pelvic inflammatory disease;treatment from liver;clinical experience
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发布时间：2022-08-31 - 摘要：Objective:To observe the effect of ovariectomy on the protein expression of CREB in model of MCAO rats and the intervening influence of “Zuogui Pills”. Methods64 female wistar rats were randomly divided into 4 groups and each group has 16 rats as following:the sham operation group,the cerebral ischemia group,the cerebral ischemia with ovariectomy group and the cerebral ischemia with ovariectomy given Chinese medicine group. Middle cerebral artery occlusion (MCAO) was operated in rats except the rats in sham operation group,and ischemia-reperfusion were used 2 hours after MCAO. The cerebral ischemia with ovariectomy group was bilateral ovary removed 10 days before the MCAO operation. The cerebral ischemia with ovariectomy given Chinese medicine group was also bilateral ovary removed 10 days before the MCAO operation and given“Zuogui Pills”gavage (1.62g/kg) one times a day from 3 days before MCAO surgery for consecutive 10 days. Immunohistochemistry and western blotting were used to assess the level of CREB. Results:Compared with the sham operation group, the expression of CREB increased (P<0.05)；compared with the cerebral ischemia group, the expression of CREB in the cerebral ischemia with ovariectomy group decreased obviously (P<0.05)；compared with the cerebral ischemia with ovariectomy group, the expression of CREB in the the cerebral ischemia with ovariectomy given Chinese medicine group increased obviously (P<0.05). Conclusion:CREB expression was increased after cerebral ischemia may be a defensive response of body. Sex hormone deprivation can significant aggravate cerebral ischemia reperfusion induced brain injury and down-regulation of CREB expression. “Zuogui Pills ” can against the impairment,which is likely achieved by activation of CREB,which showed that “Zuogui Pills ” of traditional Chinese medicine may have hormone like effect,and might promote the recovery of ischemic brain injury through up-regulation of CREB expression.关键词：kidneys communicating to the brain;cerebral ischemia;reperfusion;“Zuogui Pills”;CREB
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发布时间：2022-08-31 - 摘要：Objective:To investigate the Effects of Kangxianling prescription on renal function By Hypertensive renal damage in mice. Methods60 mice with blood pressure were randomly divided into 5 groups. The Model group,fosinopril group, Kangxianling group of them underwent unilateral nephrectomy and infusion of angiotensin II using a micro-osmotic pump. The normal group was not treated, physiological saline control group underwent unilateral nephrectomy and infusion of physiological saline using a micro-osmotic pump. Each group were fed ad libitum, Kangxianling group with Kangxianling prescription administration by gavage once a day ; Monopril group were given Monopril by gavage once a day; the rest of the group fed tap water. After 4 weeks of treatment,detected the killed mice. Urine of laboratory mice in each group was collected to measure 24-hour urine protein quantitative. The blood taken from orbital venous was used to test serum creatinine (Scr),blood urea nitrogen(BUN). Results:The experiment in the second week The levels of blood pressure in Kangxianling group and monopril group decline compared with those in the model group(P<0.05).The experiment in the fourth week The levels of blood pressure in Kangxianling group and monopril group decline compared with those in the model group(P<0.05).The levels of Scr in model group and saline control group significantly increased compared with those in the normal group (P<0.05);the BUN levels in the model and monopril group of significant increases than the normal group (P<0.05);and the 24-hour urine quantitative protein in the normal group、saline control group and monopril group all decreased significantly compared with those in the normal group(P<0.01). Conclusion:This study shows that fiber resistance spirit can reduce blood pressure in mice,Kangxianling can improve the hypertensive renal damage mice renal function.关键词：hypertensive renal damage;Kangxianling prescription;angiotensin II;osmotic pumps.
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发布时间：2022-08-31 - 摘要：Objective:To detect the immune induced Sjgren’s syndrome model rat’s CD4+ CD25+ Foxp3T cells (Treg) and Th17 cell level from peripheral blood,at the same time observe the improvement of the affected glands and the changes of peripheral blood lymphocyte subsets. MethodsMale BABL/C mice were divided into blank group, model group, hydroxychloroquine group and “Shengjin Renzao Prescription” high, middle, low-dose groups. The mice in all the groups except the blank group were established the sjogren’s syndrome in mice model by the immune inducing. Each group was intervened respectively. The level of CD4+、CD8+、CD4+ CD25+ Foxp3T cells and Th17 cell in the peripheral blood of mice was detected by using flow cytometry,and saliva,tear secretion of model rats was determined; At the end of its treatment,observe the change of submaxillary gland tissue morphology. Results:Compared with blank group, saliva and tear secretion of the mice from the first week to the fourth week in the model group decreased obviously(P<0.05)；compared with model group, saliva and tear secretion of the mice in “Shengjin Renzao Prescription” each dose group increased from the second, the third and the fourth week(P<0.05). Compared with blank group, the level of Th17 lymphocyte cell in model group increased(P<0.05). Compared with model group, “Shengjin Renzao Prescription” each dose group can increase level of CD8+T lymphocyte cell and decrease Th17 lymphocyte cell, and increase level of Treg cell, and there was significant difference(P<0.05). The morphologic observation showed that “Shengjin Renzao Prescription” can inhibit lymphocyte infiltration of submandibular gland stroma in model mice. Conclusion:“Shengjin Renzao Prescription” can improve the symptom of the SS in mice by adjusting the response function of lymphocytes.关键词：Sjgren’s syndrome;CD4;+;CD8;Th17;CD25;Foxp3T cell
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发布时间：2022-08-31 - 摘要：Objective:To observe the effects of solanine on SW480 cell apoptosis of human with colon cancer and the related factors in ERK/MEK, PI3K/AKT signal pathway. MethodsThe SW480 colon cancer cell was divided into 5 groups after the cultivation, blank control group, culture solution control group and solanine 4,8, 16 mmol/L groups, each group administered with intervention respectively. The proliferation function of solanine on colon cancer cell line was tested with MTT method, the effects of solanine on colon cancer cell apoptosis was tested with FCM, the expression of ERK/MEKand PI3K/AKT in SW480 cell that treated with solanine was detected with RT-PCR and Western blotting method. Results:MTT growth curve showed that solanine could inhabite the proliferation of colon cancer SW480 cell line. Flow Cytometry showed that solanine could promote the SW480 cell apoptosis. RT-PCR showed that solanine could inhabite the expression of ERK1/2 mRNA. Western blotting showed that solanine could decrease the protein expression in the MEK/ERK and PI3K/AKT signal pathway. Conclusion:Solanine could inhabite the proliferation of colon cancer, and the cell apoptosis induction was realized may be though MEK/ERK and PI3K/AKT signal pathway.关键词：solanine;MEK/ ERK;PI3K/Akt;colon cancer
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发布时间：2022-08-31 - 摘要：Objective:To explore the optimum technological conditions for preparing collagen from brown frog(Rana Dybowskii) body by pepsin,and to determine the purity of collagen and contents of amino acids. MethodsBy determining extraction rate,single-factor trials and orthogonal experiments were used to optimize technological conditions for preparing collagen from the body of this brown frog with pepsin. The type of pepsin-solubilized collagen(PSC) was determined by ultraviolet and visible spectrophotometer(UV),and the contents of amino acids in PSC were determined by using reversed phase high performance liquid chromatography(RP-HPLC); ResultsThe optimum technological conditions of PSC were that 37 ℃ for temperature,20% for E/S,1∶20 for the ratio of material to solvent and 12h for time. Under these conditions,the extraction rate of PSC was up to 88.6%. The PSC had the strongest absorption peak at 234 nm through UV analysis. Results: of RP-HPLC analysis showed that PSC contained abundant of amino acids,especially 8 essential amino acids needed by human body,in which Gly,Pro,Leu and Ala had higher contents than the others,which matched with the features of collagen Ⅰ. Conclusion:The optimized preparation method had high extraction rate and good repeatability, thus could provide references for technological production of PSC.关键词：brown frog body;pepsin;collagen;preparation technology;essential amino acid
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发布时间：2022-08-31 - 摘要：This paper summarizes the research development of effect of Herba Cistanche on the reproductive system. Study has proved that Herba Cistanche can promote the sex hormone secretion or have gonadotripic effect, and it has good protection for spermatogenic function and semen quality. It also can improve renal function,and have promoting for embryo development. Herba Cistanche can promote the reproduction effectively.关键词：Herba Cistanche;reproduction;pharmacological action;review
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发布时间：2022-08-31 - 摘要：This paper summarizes the development of myelodysplastic syndrome TCM syndrome type. In TCM, Myelodysplastic syndromes is differentiated into syndrome type of toxic heat flourishing, phlegm-dampness stagnation, Yang deficiency of spleen and kidney, deficiency of qi and blood, deficiency of the kidney essence. Modern research has found that there are relationship between TCM syndrome type and metabonomics, growth factor.关键词：myelodysplastic syndromes;TCM syndrome type;overview
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发布时间：2022-08-31
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