最新刊期

    11 2015
    • WANG Li-yu,SHEN Yan
      Vol. 49, Issue 11, Pages: 36-39(2015)
      摘要:Objective:To observe the clinical efficacy of “Yixin Decoction” combined conventional western medicine to treat Atrial Fibrillation  Methods:72 patients diagnosed as atrial fibrillation were randomly divided into the control group and the test group, each group included 36 people. The control group was treated with conventional western medicine, and the test group was treated with Western medicine and “Yixin Decoction”. After three months of treatment, observe the clinical efficacy and compare the changes of Echocardiography, the lever of Hs-CRP, TNF-α, NADPH oxidase and SOD in serum before and after treatment  Results:①30 people in the test group and 31 people in the control group completed the study. ②The effective rate of the test group was 86.7%, and the control group was 58.1%, the difference was statistically significant (P<0.05). ③The effective rate of TCM syndrome of the test group was 86.7% and the control group was 60.00%, and the difference between the two groups after treatment was statistically significant(P<0.05). ④The difference of the LVEDD between the two groups after treatment was statistically significant (P<0.05), and the LVEDD of treatment group decreased significantly (P<0.05). ⑤Comparing the two groups after treatment, the difference of the lever of Hs-CRP, TNF-α, NADPH oxidase and SOD was statistically significant (P<0.05)  Conclusion:The clinical efficacy of “Yixin Decoction” combined conventional western medicine to treat atrial fibrillation is significant. By reducing the level of inflammation and oxidative stress, “Yixin Decoction” can reverse myocardial remodeling in a certain extent.  
      关键词:atrial fibrillation;“Yixin Decoction”;inflammation;oxidative stress;myocardial remodeling   
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      发布时间:2022-08-31
    • YE Xu-xing,XU Bin
      Vol. 49, Issue 11, Pages: 40-42(2015)
      摘要:Objective:To observe the curative effect of “Jiuzi Dihuang Decoction” on primary desiccation syndrome patients  Methods:60 diagnosed primary desiccation syndrome patients were divided randomly into treatment group and control group, 30 in each group. The patients of control group were administered with Hydroxychloroquine Sulfate Tablets, while the treatment group with “Jiuzi Dihuang Decoction”. Two groups were treated for 3 months. The changes of the clinical symptom scores, the length of Schirmer test and tear cytokine levels were observed  Results:①Within group comparison before and after the treatment, the differences of the clinical symptom scores were statistically significant in both two groups (P<0.05); Compared in each group, the difference of the clinical symptom scores before and after the treatment was statistically significant (P<0.05). ②Within group comparison before and after the treatment, the differences of the length of Schirmer test were statistically significant in both two groups (P<0.05); Compared in each group, the difference of the length of Schirmer test between before and after the treatment was statistically significant (P<0.05). ③Tear cytokine IL-2,IL-4,IL-10 could not be detected before and after the treatment. Within group comparison before and after the treatment, the differences of the positive rate of INF-γ and IL-6 were statistically significant in both two groups (P<0.05); Between group comparison of the differences of the positive rate of INF-γ and IL-6 between before and after the treatment, the differences were statistically significant (P<0.05)  Conclusion:“Jiuzi Dihuang Decoction” can both relieve clinical symptoms and increase lacrimal secretion. The mechanism may be modulating the immune system and reducing inflammation by depressing expression of CD4+T cell.  
      关键词:primary desiccation syndrome;“Jiuzi Dihuang Decoction”;cytokine;lacrimal secretion   
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      发布时间:2022-08-31
    • DU Le-yi,TANG Bi-xin,WU Kun-lun,Fan Chun-xiang,ZHANG Rong
      Vol. 49, Issue 11, Pages: 43-45(2015)
      摘要:Objective:To observe clinical effect of “Xiangsha Liujun Combined Nourishing Yin Decoction” in treating postprandial distress syndrome patients  Methods:72 patients with postprandial discomfort comprehensive syndrome were randomly divided into treatment group and control group,36 in each group. The treatment group was treated with “Xiangsha Liujun Combined Nourishing Yin Decoction” and the control group was treated with Domperidone Tablets,14 days as a course for each group. The clinical efficacy and symptom score before and after treatment of the two groups were evaluated  Results:① The total effective rate of the treatment group and the control group were 94.4% and 69.4% respectively,the difference between the two groups was significant(P<0.05). ② After treatment,the clinical symptom score of the treatment group were significantly decreased(P<0.05), while the scores of abdominal fullness and distention, diet reducing, belching and defecation inhabiting of the control group were significantly decreased(P<0.05) and there was no obvious changes in the scores of weakness and mouth dryness in the control group(P<0.05)  Conclusion:“Xiangsha Liujun Combined Nourishing Yin Decoction” has good curative effect in treating postprandial distress syndrome.  
      关键词:postprandial distress syndrome;“Xiangsha Liujun Combined Nourishing Yin Decoction”;clinical efficacy   
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      发布时间:2022-08-31
    • WANG Wei
      Vol. 49, Issue 11, Pages: 46-47(2015)
      摘要:Objective:To observe the clinical efficacy of “Shengjiang Xiaopi Decoction” in the treatment of diabetic gastroparesis  Methods:Seventy-six subjects were randomized into two groups:treatment group in which 38 cases were treated with “Shengjiang Xiaopi Decoction” and control group in which 38 cases were treated with Domperidone Tablets, with a course of four weeks. The clinical efficacy, syndrome scores and serum gastrin were observed  Results:The total effective rate was 86.48% in the treatment group and 71.05%, with a difference between the two groups(P<0.05). After treatment, the syndrome scores and gastrin levels were reduced in both groups(P<0.05), with lower score and level in the treatment group than in the control group(P<0.05)  Conclusion:“Shengjiang Xiaopi Decoction” is quite effective for diabetic gastroparesis by reducing serum gastrin.  
      关键词:diabetes mellitus;gastroparesis;“Shengjiang Xiaopi Decoction”;gastrin   
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      发布时间:2022-08-31
    • HAN Wen-jun,SUN Jian-ming,DONG Sheng-dong,LIU Juan,SONG Xiao-yun,LIU Peng,NI Chen,YE Jing-hua
      Vol. 49, Issue 11, Pages: 48-50(2015)
      摘要:Objective:To observe the clinical effect of Ye’s“Congrong Lianqiao Decoction”treating premature ejaculation  Methods:60 cases with premature ejaculation were randomized into treatment group and control group,30 cases in each group. The treatment group was given Ye’s“Congrong Lianqiao Decoction”while control group was given “Jingshuibao Capsule”. The treatment course was 3 months. PEDT, mate satisfaction grade, T, PRL were observed.Results①After treatment,the total effective rate of the treatment group was 83.33%,while the control group was 56.67%. A significant difference was observed between the two groups(P<0.05). ②Compared before and after treatment,the difference of PEDT score and mate satisfaction grade in both groups were significant(P<0.05). After the treatment,there was significant difference in PEDT score between the two groups(P<0.05)and the treatment group was better than the control gourp,while no significant difference in mate satisfaction grade between the two groups(P>0.05). ③After the treatment,there was no significant difference in T and PRL levels between the two groups(P>0.05)  Conclusion:Ye’s “Congrong Lianqiao Decoction”has curative effect on premature ejaculation. The mechanism maybe has no relationship with sex hormone regulating.  
      关键词:premature ejaculation;“Congrong Lianqiao Decoction”;satisfaction of sexual life;androgen;YE Jinghua   
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      发布时间:2022-08-31
    • FU Jin-rong,WEN Huan-huan,ZHANG Qiong,QI Cong,WANG Long-hui
      Vol. 49, Issue 11, Pages: 51-53(2015)
      摘要:Objective:To observe the clinical efficacy of combined Cai’s tube-unblocking therapy and tubal liquid instillation in the treatment of tubal infertility  Methods:Seventy-three subjects were divided into two groups:control group in which 41 cases were treated by Cai’s tube-unblocking therapy, and treatment group in which 32 cases were treated by Cai’s tube-unblocking therapy and tubal liquid instillation, with a course of six menstrual cycles. The pregnancy rate and tubal condition were observed  Results:①The total effective rate was 90.24% in the control group and 100% in the treatment, with no difference between the two groups(P>0.05). ②The overall pregnancy rate was 36.59% in the control group and 37.5% in the treatment group, with no difference between the two groups(P>0.05). ③The three-month pregnancy rate was 26.67% in the control group and 66.67% in the treatment group, with higher rate in the treatment group than in the control group(P<0.05). ④The tube-recovering rate was 38.00% in the control group and 70.27% in the treatment group, with higher rate in the treatment group than in the control group(P<0.05)  Conclusion:Combined Cai’s tube-unblocking therapy and tubal liquid instillation can increase the short-term pregnancy rate and tube-recovering rate in the treatment of tubal infertility.  
      关键词:tubal infertility;combined Cai’s tube-unblocking therapy;pregnancy rate;Cai Xiao-sun   
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      发布时间:2022-08-31
    • LI Qiao,TAN Jin-hong
      Vol. 49, Issue 11, Pages: 54-56(2015)
      摘要:Objective:To investigate the clinical effects of radiofrequency ablation combined with herbal fumigation for treatment of lumbar disc herniation  Methods:80 patients with lumbar disc herniation were equally divided into treatment and control groups with 40 patients:the control group received radiofrequency ablation, and the treatment group received radiofrequency ablation combined with herbal fumigation, all treatment for 4 weeks  Results:The excellent rates in the treatment group and the control group were 92.5% and 75.0% respectively so that the treatment group was significantly higher than the control group (P<0.05).The lumbar flexion strength of the treatment group and the control group after treatment were significantly higher than before treatment with statistically significant (P<0.05). After treatment, the JOA scores were significantly higher than that before treatment, and VAS scores were significantly lower than before treatment, and there were significant differences in comparison with before treatment (P<0.05), while the JOA and VAS score compared between the two groups after treatment were also statistically significant (P<0.05)  Conclusion:Radiofrequency ablation combined with herbal fumigation for lumbar disc herniation can promote the recovery of lumbar function.  
      关键词:lumbar disc herniation;radiofrequency ablation;herbal fumigation;lumbar function   
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      发布时间:2022-08-31
    • ZHANG Qi,WANG Ming-hua,ZHANG Yong-an,PAN You-zhen,GUO Xiu-tian,XU Hui-lei,ZHOU Feng,ZHAI Min,FU Jun-wei,TANG Hai-ming,ZHENG Zhen-lin,DONG Qing-jun,HU De-chang,LU Jin-gen
      Vol. 49, Issue 11, Pages: 57-61(2015)
      摘要:Objective:To observe the clinical effect of manual reduction combined “Lingxue Sanyu Decoction” orally and sitz bath in the treatment of incarcerated hemorrhoids  Methods:120 patients with incarcerated hemorrhoid were randomly divided into three groups:combination group, control group 1 and control group 2,0 cases in each group. The combination group were treated by manual reduction combined “Lingxue Sanyu Decoction ”orally and sitz bath,control group 1 were treated by manual reduction combined “Lingxue Sanyu Decoction ” orally, control group 2 were treated by manual reduction combined “Lingxue Sanyu Decoction ” sitz bath. The treatment course of each group was 1 week. The clinical effect and the changes of primary clinical symptoms in all cases were observed and given safety evaluation after treatment  Results:①The final subjects was 110 patients, combination group of 37 cases, control group 1 of 37 cases, and control group 2 of 36 cases. ②The total effective rates was 100.00% in combination group, 83.78% in control group 1 and 88.89% in control group 2. Clinical curative effect comparison between combination group and control group 1, combination group and control group 2, the difference was statistically significant(P<0.05), while there was no statistically significant difference between control group 1 compared with control group 2(P>0.05). ③After the treatment, the symptoms and signs scores were significantly lower in the combination group than that of control group 1 and control group 2(P<0.05). ④The incidence of adverse reactions of each group, there was no statistically significant difference between all the groups(P>0.05)  Conclusion:Manual reduction combined “Lingxue Sanyu Decoction” orally and sitz bath for treatment of Incarcerated hemorrhoids was an effective therapy with TCM characteristics.  
      关键词:incarcerated hemorrhoids;combination therapy;manual reduction;“Lingxue Sanyu Decoction”;orally;sitz bath   
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      发布时间:2022-08-31
    • WANG Chen,SHI Qi
      Vol. 49, Issue 11, Pages: 1-3(2015)
      摘要:This article introduces Prof. Shi Qi’s experience in differentiating and treating osteonecrosis of femoral head. It is believed that disturbance of qi and blood and phlegm-accumulation stasis are the etiology and pathogenesis. The therapeutic principles include regulating qi and activating blood, viscera syndrome differentiation, treating musculo-skeletal diseases, complementation of static and dynamic, reinforcing the healthy qi and dispelling the pathogenic factors; focus on inner and outer, regulating the balance. The treatment by stages, complementation of static and dynamic, combination of Chinese and western medicine and holistic therapy are advocated in clinic.  
      关键词:osteonecrosis of femoral head;famous doctor’s experience;Shi Qi   
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      发布时间:2022-08-31
    • JIANG Jian
      Vol. 49, Issue 11, Pages: 4-7(2015)
      摘要:This paper explained the main manifestation of masked depression. Masked depression syndrome can be divided into “general cloak of depression syndrome”,“colorful cloak of depression syndrome”,and “weird cloak of depression syndrome”. Masked depression syndrome can be differentiated and diagnosed easily through the etiology,emotional manifestation,physique and natural endowment,personality features,mental disorders’ knowledge,the main points of four diagnosti  Methods:,as well as diagnostic treatment. The principle-method-recipe-medicines of depression syndrome has a big dispersion degree. The treatment based on syndrome differentiation should be flexible. We should pay attention on using the active placebo effect. We cure the disease can also help to dispel melancholy when the depression syndrome coexists with disease. Masked depression syndrome includes the somatoform disorders,autonomic dysfunction induced by recessive mental factors,and various kinds of physiological disorders. The pathogenesis of masked depression syndrome is related to inheritance,personality and psychological defense mechanism,cognitive ability,as well as alexithymia of the patients.  
      关键词:depression syndrome;masked depression syndrome;diagnosis;treating from the aspect of depression;placebo effect;mental disorders;somatoform disorders   
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      发布时间:2022-08-31
    • ZHANG Ting
      Vol. 49, Issue 11, Pages: 8-10(2015)
      摘要:This paper analyzed the etiology and pathogenesis of TCM treatment of chronic kidney disease proteinuria, put forward the occurrence of proteinuria may have originated from different theoretical explanation, such as the wind pathogen, dampness-heat, blood stasis of kidney, sinking of spleen-qi, failure to storage of kidney-qi. We emphasized that using clinical application promoting blood circulation to remove blood stasis treatment shall meet the relevant indications. We thought that the organic combination of the treatment of traditional Chinese medicine and the pathogenesis can be helpful to receive the good clinical curative effect.  
      关键词:chronic kidney disease;urine protein;etiology and pathogenesis;therapy;activating blood and resolving stasis   
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      发布时间:2022-08-31
    • LIU Ying-hua,HOU Li-hui,XU Fang,LI Yan
      Vol. 49, Issue 11, Pages: 11-14(2015)
      摘要:Objective:To discuss the clinical and biochemical features of polycystic ovary syndrome with obese women of phlegm constitution  Methods:166 cases of polycystic ovary syndrome with obese women were collected, in which 43 belong to phlegm constitution group and 37 belong to tendency phlegm constitution group, 86 belong to non-phlegm constitution group; clinical and biochemical characteristics in each group were analyzed and compared  Results:①There was no statistic difference in ages, BMI,WC,HC,WHR,diastolic blood pressure during the three groups(P>0.05); the age at menarche of phlegm constitution group was significantly higher than non-phlegm constitution group and tendency phlegm constitution group(P<0.05)while diastolic blood pressure of phlegm constitution group was significantly lower than that of tendency phlegm constitution group(P<0.05). ②There was no statistic difference in sex hormone, blood glucose and blood lipid index in each group(P>0.05) but sex hormone with SHBG of phlegm constitution group was significantly higher than that of non-phlegm constitution group(P<0.05). ③There was no statistic difference in living styles such as eating snack, sweet dish, fried food and sports during the three groups(P>0.05). ④Incidence of first degree family history of TDM,hypertension,premature balding of phlegm constitution group was significantly higher than that of non-phlegm constitution group(P<0.05); Incidence of first degree family history of TDM of tendency phlegm constitution group was significantly higher than that of non-phlegm constitution group(P<0.05)  Conclusion:It was showed that the age at menarche of polycystic ovary syndrome with obese women of phlegm constitution was late, and diastolic blood pressure was low; most patients have family history of TDM, hypertension and premature balding; reproductive hormone and metabolic indices of phlegm constitution group was similar with non-phlegm constitution group but sex hormone with SHBG of phlegm constitution group was significantly higher.  
      关键词:polycystic ovary syndrome;phlegm constitution;clinical features;sex hormone;glucose metabolism;lipid metabolism   
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      发布时间:2022-08-31
    • WANG Qing-qi,WANG Shao-mo,FEI Xiao-yan,DAI Yan-cheng,LIU Tao,CHEN Zhen,XUE Hui
      Vol. 49, Issue 11, Pages: 15-18(2015)
      关键词:stamach cancer;mass syndrome;teaching ward round   
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    • ZHANG Peng,YANG Kang,WANG Wei,DU Rui-kai
      Vol. 49, Issue 11, Pages: 19-21(2015)
      摘要:This paper introduce Professor Wang Ankang’s clinical features and experience in treating cough and asthma. It is believed that the etiology of this disease is multiple and has relationship with disorder of lung qi; as to the principle of treatment, we should pay more attention of phlegm, but treating phlegm is not enough; we should differentiating this disease with Xu and Shi for Xu syndrome is not the only course of cough and asthma syndrome; the treatment should be given according to different patients, children and women should regulating stomach, nourishing yin.  
      关键词:cough and asthma;TCM therapy;Wang Ankang   
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      发布时间:2022-08-31
    • LI Qiu-shi,JIANG De-you
      Vol. 49, Issue 11, Pages: 22-23(2015)
      关键词:“Shengyang Yiwei Decoction”;famous docter’s experience;Jiang Deyou   
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      发布时间:2022-08-31
    • MA Jing
      Vol. 49, Issue 11, Pages: 24-27(2015)
      摘要:This paper discusses the clinical application of associated prescriptions in Treatise on Febrile Diseases in gynecology, the associated prescriptions include 11 such as “Guizhi Decoction”, “Mahuang Decoction”, “Gegen Decoction”, “Chaihu Decoction”, “Zhizi Decoction” and “Chengqi Decoction”.  
      关键词:Treatise on Febrile Diseases;prescription;gynecology   
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      发布时间:2022-08-31
    • ZENG Wei-ying,WANG Ji-hong,LAI Xin-sheng
      Vol. 49, Issue 11, Pages: 28-30(2015)
      摘要:This paper aims to find out the characteristics of point locating and the action mechanism of Tongyuan acupuncture in view of the theory of “Peripheral Movement Driven by Shenque”. Tongyuan point locating in belly like turtle lying on the Shenque, and the action mechanism include holding congenital Zhenyuan and postnatal spleen and stomach. Tongyuan point locating can transport axis and operating wheel, reinforcing qi and blood, asjusting qi, cultivating sprit.  
      关键词:Tongyuan acupuncture therapy;“Peripheral Movement Driven by Shenque”;clinical significance   
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    • JU Xiao-rong,MA Yong-qi
      Vol. 49, Issue 11, Pages: 31-33(2015)
      摘要:This paper discusses the prevention and treatment of cardiac and cerebral diseases from the perspective of phlegm and bloodstasis. Phlegm and bloodstasis stasis is closely related to the initiation, development and recurrency of cardiac and cerebral diseases, thus, preventing and curing the cardiac and cerebral diseases from the perspective of phlegm and bloodstasis is a better breakthrough point, and it has superiority and characteristic; at the same time, it can also provide a new thinking and method for the prevention, cure and recovery of cardiac and cerebral diseases.  
      关键词:phlegm and bloodstasis;heart-brain disease;preventive treatment of disease;thought   
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      发布时间:2022-08-31
    • WU Yan-fei,QIANG Ya
      Vol. 49, Issue 11, Pages: 34-35(2015)
      关键词:ascites;TCM therapy;“Jueliu Decoction”;external application   
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    • WANG Qin,WANG Sheng-fei,ZHANG Yong-tai,JIAO Li-jing,WANG Qing,DONG Chang-sheng,XU Ling
      Vol. 49, Issue 11, Pages: 62-66(2015)
      摘要:Objective:This study designed to observe the analgesic effect of total flavonoids of Rhizoma Arisaematis nanogel on Walker256 induced bone cancer pain model,and explore the analgesic mechanism  Methods:Female SD rats were randomly divided into five groups:blank group,sham operation group,Rhizoma Arisaematis group and zoledronic acid group, 9 in each group. Series of indexes were observed including mechanical thresholds,thermal thresholds,dynamic weight bearing ability together with bone HE stain and bone radiology  Results:Indicated that rat model of hyperalgesia and allodynia was achieved after intra-tibial injection of Walker 256 cells. The thermal thresholds and dynamic weight bearing ability of control rats and bone caner rats were significant different (P<0.05). However difference of mechanical thresholds between control rats and bone cancer rats was not remarkable (P>0.05). Furthermore,Trabecular number in Rhizoma Arisaematis group and zoledronic acid group was highly increased compared with the control group  Conclusion:Total flavonoids of Rhizoma Arisaematis nanogel may have the analgesic effect in the development of bone cancer,and this finding might provide a new analgesic strategy for reducing cancer pain.  
      关键词:bone cancer pain;Rhizome Arisaematis;total flavonoids;Nanogel;MicroCT;Trabecular   
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      发布时间:2022-08-31
    • MA Zhi-heng,ZHONG Li-ping,YU Ke-na,HE Li-qun
      Vol. 49, Issue 11, Pages: 67-70(2015)
      摘要:Objective:To determine effects of “Kangxianling Decoction” (KXLD) on the Akt-mTOR signaling pathway in 5/6 nephrectomized mice renal fibrosis model and discuss mechanism of it  Methods:SPF C57BL/6J male mice were established models of chronic renal failure caused by 5/6 nephrectomized,and two week later after surgery,according to serum creatinine (Scr) level,the mice were divided into model group,KXLD and rapamycin (RAP) group,sham operation group was set at the same time, 10 in each group. KXLD and RAP group were gavaged respectively according to 20 g/kg,RAP 0.8 μg/g,0.5 ml/day. Sham and model groups were administered with the same amount of distilled water. The mice were sacrificed after 8 weeks of treatment,Scr,BUN and 24 h UP were determined, the levels of Akt-mTOR protein and mRNA expression were observed by Western blotting and real-time PCR method  Results:Compared with sham group,the Scr,urea nitrogen,24 h UP and p-Akt,p-mTOR levels increased significantly in the model group (P<0.05, P<0.01). Compared with model group,the Scr,urea nitrogen,24 h UP and p-Akt,p-mTOR protein and Akt,mTORmRNA levels decreased significantly in the KXLD and RAP group (P<0.01, P<0.05). Compared between KXLD and RAP groups,in Scr,24 h UP,KXLD superior to RAP,in mTOR protein and mRNA,RAP superior to KXLD(P<0.05)  Conclusion:“Kangxianling Decoction” is able to protect renal function via Akt-mTOR signaling pathway.  
      关键词:“Kangxianling Decoction”;chronic renal fibrosis model;Akt-mTOR signaling pathway   
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      发布时间:2022-08-31
    • LUO Ting,CHEN Jin-guo,JIAN Yi-juan,HU Zheng-guo,DONG Fei-xia,CHEN Yu,WANG Ya-hui
      Vol. 49, Issue 11, Pages: 71-78(2015)
      摘要:Objective:To investigate the influence and mechanism of “Qinghua Gushen Paidu Decoction” on renal tubular epithelial mesenchymal transition in unilateral ureteral obstruction (UUO) rats  Methods:A rat model of renal fibrosis was prepared by unilateral ureteral obstruction. 108 SD rats were randomly divided into sham operation group(n=18),UUO model group(n=18),“Qinghua Gushen Paidu Decoction” high dose(n=18), middle dose(n=18) and low dose(n=18) groups, and Lotensin treated group(n=18).The 6 groups of rats were treated with corresponding drugs,once a day. Mental conditions,activities,hair color,shape of stool,and body weight were observed during administration. At 7, 14, and 21 days, 6 rats in each group were randomly sacrificed. Then 24h urine was collected and 24h urinary protein (24h UP) was detected. Serum blood urea nitrogen(BUN)and serum creatitine(Scr) were also tested. The left surgery renal tissue were collected for pathological examinations. The pathological changes of the obstruction renal tissue were examined by Hematoxylin and eosin staining (HE). The protein expressions of TGF-β1 and α-SMA were detected by immunohistochemical staining  Results:Compared with the sham-operation group,the general condition of the rats was poorer in the other groups,their body weight grew slower,and serum levels of BUN,Scr increased(P<0.05),the renal tubular damaged comparatively serious(P<0.05),protein expression levels of TGF-β1,α-SMA increased in the renal tissue(P<0.05). The renal interstitial fibrosis degree was gradually aggravated along with the ureteral obstruction time. Compared with the model group,the serum levels of BUN,Scr decreased(P<0.05)in the rats of the TCM groups (high, middle and low dose groups) and Lotensin treated group, the condition of the damage of the renal tubular get better(P<0.05), protein expression levels of TGF-β1,α-SMA decreased(P<0.05). Compared with the Lotensin treated group, no significant difference in effect on indexes was observed between TCM groups and Lotensin treated group(P>0.05). No significant difference in effect on indexes was observed between the high, middle and low dose groups(P>0.05)  Conclusion:“Qinghua Gushen Paidu Decoction” may inhibit the EMT by down-regulating the expression of TGF-β1,α-SMA, can protect the kidney and ameliorate renal interstitial fibrosis.  
      关键词:renal interstitial fibrosis;EMT;TGF-β;1;α-SMA   
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    • ZHAO Dong-hai,MA Yan-yan,WANG Hong-yu,LI Hao-liang,MA Shuai
      Vol. 49, Issue 11, Pages: 79-82(2015)
      摘要:Objective:To explore the efficacy of Schizandra Chinensis polysaccharide (SCP) on dyszoospermia of mice exposed to microwave radiation and its effects on reproductive hormones  Methods:Fifty male BALB /C mice were randomly divided into normal control group,model group,low dose SCP group,middle dose SCP group and high dose SCP group. Except normal control group,the dyszoospermia mouse models were established by exposed to microwave of 1450 MHz frequency,power density of 50 mW/cm2 for 1 h each day for 12 consecutive days. After modeling,SCP (100,0 and 400 mg/kg) was intragastrically administered at corresponding dose to the low, middle and high dose SCP groups.Equal volume of 0.9%NaCl solution was given to rats in the normal control group and the model group by gastric gavage. All the medication was performed once daily for 30 successive days. The blood serum, testis and epididymis were withdrawal 24 h after the last intragastric administration. The levels of follicle stimulating hormone (FSH),luteinizing hormone (LH),and testosterone (T) in the testis homogenate were determined by enzymelinked immunosorbent assay. The sperm count,the motility rate,and the teratospermia rate were compared. The morphology of the testis was observed using HE staining  Results:Compared with normal control group,the sperm count and the motility rate decreased,the teratospermia rate increased(P<0. 01). The serum levels of FSH and LH increased,the T content in the testis homogenate decreased in the model group,showing statistical difference (P<0.01). Compared with the model group,the sperm count and the motility rate increased,the teratospermia rate decreased,the serum levels of FSH and LH decreased,the T content in the testis homogenate increased in all SCP groups,showing statistical difference (P<0.01 ). All the indices showed dose-dependent manner in the SCP groups. The histologica  Results: showed the pathological injury in the testicular tissue was improved in all SCP groups  Conclusion:SCP showed obvious therapeutical effects on dyszoospermia of mice exposed to microwave radiation,and its mechanisms might be correlate with improving reproductive hormone level and recovering the regulation function of hypothalamus-hypophysis-gonad axis.  
      关键词:microwave;electromagnetic radiation;Schizandra Chinensis polysaccharide;dyszoospermia;reproductive hormone   
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    • LI Tong-li,ZHAO Guo-ying,YUAN Xiu-rong,ZHOU Hua,XUE Jin-gui
      Vol. 49, Issue 11, Pages: 83-86(2015)
      摘要:Objective:To optimize the extraction and purification techniques of “Luhong Prescription”  Methods:Astragaloside IV, hydroxysafflor yellow A extraction rate and yield rate of dry extract as the chemical index, the amount of water, soaking time and extraction time on the extraction process were investigated by orthogonal design test. The purification process of “Luhong prescription” was determined by using single factor test  Results:Optimization of extraction process were as follows:with 8 times amount of water, soaking for 30 minute, decocting two times, each time with 30 minutes; Optimization of purification technology is high-speed centrifugation, speed is 10 000 r/min, time is 10 minutes  Conclusion:The extraction and purification process is reasonable, stable and feasible, and can provide reference basis for further research and development of “Luhong Prescription”.  
      关键词:“Luhong Prescription”;astragaloside Ⅳ;hydroxysafflor yellow A;orthogonal test   
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    • HE Zhong-mei,LI Kuo,ZHU Hong-yan,ZHAO Yan,YANG He,ZHANG Lian-xue,GAO Yu-gang
      Vol. 49, Issue 11, Pages: 87-90(2015)
      摘要:This paper reviews the recent studies of the effects on insoluble compounds of Chinese medicine such as steroids,anthraquinones,volatile oil,polyphenols,alkaloids,flavonoids and triterpenoids chemical structures which were modified by amino acids,so as to provide a strong basis for the clinical application of the insoluble active ingredients of materia medica.  
      关键词:amino acids;insoluble active ingredients of materia medica;amino acid derivatives   
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    • CHEN Li,WANG Jian
      Vol. 49, Issue 11, Pages: 91-93(2015)
      摘要:This paper briefly reviews the humoral regulation mechanism of acupuncture analgesia in recent ten years, aims to provide scientific evidence of acupuncture analgesia mechanism. Humoral regulation includes neurotransmitter regulation (5-HT, CCK-8) and cell signal regulation (MAPK, c-fos).  
      关键词:acupuncture analgesia;humoral regulation;neurotransmitter;cell signal transduction   
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