Since 2020, a global outbreak of coronavirus disease 2019 (COVID-19) has caused great concern worldwide and has been classified as a category B infectious disease managed as a category A infectious disease in China. Despite the fact that vaccination against the SARS-CoV-2 and the development of new drugs are being carried out worldwide, the SARS-CoV-2 has undergone several rounds of mutations and its infectiousness has further increased, which is still bringing negative effects to countries around the world in various aspects. Both traditional Chinese and modern medicine are actively searching for effective treatment options. In the field of traditional Chinese medicine, COVID-19 can be classified as a “plague”, and the role of TCM therapy in the fight against COVID-19 is gaining more and more attention and trust. In the same year, Shanghai J Tradit Chin Med launched a publication plan focusing on the special topic of “COVID-19 and Traditional Chinese Medicine Treatment”, in which research results and clinical experience related to the fight against COVID-19 from major epidemic areas in China were published, and some articles have been included in the WHO COVID-19 Research Database.