LI Zhijun,SHU Xingmei,HE Lei,et al.Research on modern clinical application and mechanism of action of Wumei Pill[J].Shanghai Journal of Traditional Chinese Medicine,2025,59(11):17-22.
LI Zhijun,SHU Xingmei,HE Lei,et al.Research on modern clinical application and mechanism of action of Wumei Pill[J].Shanghai Journal of Traditional Chinese Medicine,2025,59(11):17-22. DOI: 10.16305/j.1007-1334.2025.z20250430005.
Research on modern clinical application and mechanism of action of Wumei Pill
Using the SwissADME and ProTox-Ⅱdatabases,30 non-toxic components were screened from Wumei Pill. Based on existing network pharmacological and clinical studies of this formula, Wumei Pill was found to treat eight categories of diseases-including ulcerative colitis, diabetes, gastritis, gastroesophageal reflux disease,and irritable bowel syndrome-through active constituents such as quercetin and kaempferol. Its therapeutic mechanisms involve regulation of inflammatory factors,modulation of gut microbiota, metabolic regulation,and resistance to oxidative stress.
关键词
Keywords
references
LYU M , WANG Y , CHEN Q , et al . Molecular mechanism underlying effects of Wumeiwan on steroid-dependent asthma: A network pharmacology, molecular docking, and experimental verification study [J]. Drug Des Devel Ther , 2022 , 16 : 909 - 929 .
YAN S , WANG P , WEI H , et al . Treatment of ulcerative colitis with Wu-Mei-Wan by inhibiting intestinal inflammatory response and repairing damaged intestinal mucosa [J]. Phytomedicine , 2022 , 105 : 154362 .
WU F , SHAO Q , HU M , et al . Wu-Mei-Wan ameliorates chronic colitis-associated intestinal fibrosis through inhibiting fibroblast activation [J]. J Ethnopharmacol , 2020 , 252 : 112580 .
YAN S , WEI H , JIA R , et al . Wu-Mei-Wan ameliorates murine ulcerative colitis by regulating macrophage polarization [J]. Front Pharmacol , 2022 , 13 : 859167 .
CHENG Z , XIONG X , WU F , et al . Network Pharmacology research indicates that Wu-Mei-Wan treats obesity by inhibiting Th17 cell differentiation and alleviating metabolic inflammation [J]. Comb Chem High Throughput Screen , 2023 , 26 ( 1 ): 30 - 48 .