Application of a yin‑yang and five‑element theory‑based mathematical model in traditional Chinese medicine syndrome diagnosis of spastic cerebral palsy
|更新时间:2025-12-12
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Application of a yin‑yang and five‑element theory‑based mathematical model in traditional Chinese medicine syndrome diagnosis of spastic cerebral palsy
Shanghai Journal of Traditional Chinese MedicineVol. 59, Issue 12, Pages: 9-13(2025)
DU Xiaogang,SONG Hujie,WANG Xing.Application of a yin‑yang and five‑element theory‑based mathematical model in traditional Chinese medicine syndrome diagnosis of spastic cerebral palsy[J].Shanghai Journal of Traditional Chinese Medicine,2025,59(12):9-13.
DU Xiaogang,SONG Hujie,WANG Xing.Application of a yin‑yang and five‑element theory‑based mathematical model in traditional Chinese medicine syndrome diagnosis of spastic cerebral palsy[J].Shanghai Journal of Traditional Chinese Medicine,2025,59(12):9-13. DOI: 10.16305/j.1007-1334.2025.z20250221002.
Application of a yin‑yang and five‑element theory‑based mathematical model in traditional Chinese medicine syndrome diagnosis of spastic cerebral palsy
To integrate yin-yang and five-element theory with modern mathematical modeling techniques to construct a quantitative diagnostic model for the liver hyperactivity with spleen deficiency syndrome in spastic cerebral palsy, providing a scientific basis for syndrome differentiation in traditional Chinese medicine (TCM) and improving the objectivity and accuracy of TCM syndrome diagnosis.
Methods
2
A yin-yang and five-element mathematical model was constructed based on the theoretical framework of liver hyperactivity with spleen deficiency syndrome, with core parameters such as liver qi, spleen qi, yin qi and yang qi. Clinical data were collected, parameters were quantified, and model calculations were performed to design a diagnostic algorithm for TCM syndrome differentiation in spastic cerebral palsy. The model was clinically validated, and its performance was evaluated using receiver operating characteristic (ROC) curve analysis.
Results
2
The concordance rate between the model-based diagnosis and traditional diagnosis was 93.0%. The area under the ROC curve (AUC) was 0.91 [95%
CI
(0.88–0.94),
P
<
0.001].
Conclusions
2
The mathematical model based on yin-yang and five-element theory demonstrates promising application potential in diagnosing the liver hyperactivity with spleen deficiency syndrome in spastic cerebral palsy. This paper provides a practical example of integrating TCM theory with modern mathematical modeling techniques, contributing to the standardization and objectification of TCM syndrome differentiation.
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references
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OSKOUI M , COUTINHO F , DYKEMAN J , et al . An update on the prevalence of cerebral palsy:a systematic review and meta-analysis [J]. Dev Med Child Neurol , 2013 , 55 ( 6 ): 509 - 519 .
JIANG H , LI X , JIN C , et al . Early diagnosis of spastic cerebral palsy in infants with periventricular white matter injury using diffusion tensor imaging [J]. AJNR Am J Neuroradiol , 2019 , 40 ( 1 ): 162 - 168 .
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