Objective

2

To explore the correlation between traditional Chinese medicine （TCM） syndromes and sleep monitoring indexes in patients with acute ischemic stroke （AIS） and obstructive sleep apnea hypopnea syndrome （OSAHS）.

Methods

2

Based on sleep respiratory monitoring results， 145 AIS patients were divided into two groups： those with OSAHS （

n

=81） and those without OSAHS （

n

=64）. We compared differences in gender， age， body mass index （BMI）， neck， chest， and waist circumferences， and national institutes of health stroke scale （NIHSS） scores. TCM syndromes were documen

ted and analyzed through TCM syndrome differentiation. Apnea-hypopnea index （AHI） and lowest oxygen saturation （LSpO

2

） values were compared across different severities and TCM syndromes. Binary logistic regression was used to assess the correlation between TCM syndromes and sleep monitoring indexes.

Results

2

①There were statistically significant differences in BMI， chest， and waist circumferences between the two groups （

P

<

0.05）. ②The OSAHS group primarily presented with blockade of wind-phlegm-static blood syndrome （43.2%）， whereas the non-OSAHS group showed upward disturbance of wind-fire syndrome （31.3%）. The distribution of TCM syndromes between the two groups showed statistically significant differences （

P

<

0.05）. ③Patients in the OSAHS group had higher NIHSS scores than those in the non-OSAHS group （

P

<

0.05）. ④Of the 145 AIS patients， 90 were classified as mild and 55 as non-mild. Mild AIS patients showed higher LSpO

2

values than non-mild AIS patients （

P

<

0.05）. However， there were no statistically significant differences in AHI values between the two groups （

P

>

0.05）. ⑤Significant differences were observed in AHI and LSpO

2

values among AIS patients with different TCM syndromes （

H

=27.614，

P

<

0.05；

H

=20.939，

P

<

0.05）. Further pairwise comparisons revealed that patients with blockade of wind-phlegm-static blood syndrome had the highest AHI values and the lowest LSpO

2

values （

P

<

0.05）. ⑥Binary logistic regression analysis indicated that the severity of OSAHS ［

OR

=0.635，

95%CI

（0.419～0.962），

P

<

0.05］ was an independent predictor for the upward disturbance of wind-fire syndrome. Gender ［

OR

=3.986，

95%CI

（1.178～13.488），

P

<

0.05］， AHI ［

OR

=1

.090，

95%CI

（1.046～1.136），

P

<

0.05］， and severity of OSAHS ［

OR

=3.162，

95%CI

（2.073～4.824），

P

<

0.05］ were independent predictors for the blockade of wind-phlegm-static blood syndrome. Gender ［

OR

=0.225，

95%CI

（0.060～0.850），

P

<

0.05］ and BMI ［

OR

=1.170，

95%CI

（1.025～1.335），

P

<

0.05］ were independent predictors for the qi deficiency and blood stasis syndrome. AHI ［

OR

=0.907，

95%CI

（0.826～0.996），

P

<

0.05］ was an independent predictor for the stirring wind due to yin deficiency syndrome.

Conclusions

2

In AIS patients with OSAHS， the blockade of wind-phlegm-static blood syndrome was the most common. These patients had higher AHI values and more severe nocturnal hypoxemia. Gender， BMI， AHI， and the severity of OSAHS were correlated with the TCM syndrome differentiation in AIS patients with OSAHS. These findings provide valuable insights for TCM-based diagnosis and treatment of AIS patients with OSAHS.