LI Jing,SUN Chang,ZHAO Shanshan,et al.Theoretical exploration of intergenerational effects in polycystic ovary syndrome based on latent pathogens[J].Shanghai Journal of Traditional Chinese Medicine,2024,58(11):68-72.
LI Jing,SUN Chang,ZHAO Shanshan,et al.Theoretical exploration of intergenerational effects in polycystic ovary syndrome based on latent pathogens[J].Shanghai Journal of Traditional Chinese Medicine,2024,58(11):68-72. DOI: 10.16305/j.1007-1334.2024.2403028.
Theoretical exploration of intergenerational effects in polycystic ovary syndrome based on latent pathogens
Polycystic ovary syndrome (PCOS) is a complex reproductive metabolic disorder with a genetic predisposition, and its related symptoms can be transmitted across generations. Latent pathogens in traditional Chinese medicine (TCM) are considered as pathogenic factors that lie dormant within the body and do not immediately cause diseases, bearing similarities to the mechanisms of intergenerational effects observed in PCOS. Integrating the theory of latent pathogens from TCM with modern medical understandings of mechanisms of PCOS's intergenerational effects offers new insights for the early recognition and treatment of PCOS in TCM practice.
关键词
多囊卵巢综合征伏邪理论代际效应中医理论中医药疗法
Keywords
polycystic ovary syndrometheory of latent pathogensintergenerational effecttraditional Chinese medicine theorytraditional Chinese medicine therapy
references
ESCOBAR-MORREALE H F.Polycystic ovary syndrome: definition,aetiology, diagnosis and treatment[J]. Nat Rev Endocrinol, 2018, 14(5): 270-284.
AHTAM B,TURESKY T K,ZÖLLEI L,et al.Intergenerational transmission of cortical sulcal patterns from mothers to their children[J].Cereb Cortex, 2021, 31(4): 1888-1897.
CRISOSTO N,LADRÓN DE GUEVARA A,ECHIBURÚ B,et al.Higher luteinizing hormone levels associated with antimüllerian hormone in postmenarchal daughters of women with polycystic ovary syndrome[J]. Fertil Steril, 2019, 111(2): 381-388.
KAHSAR-MILLER M D,NIXON C,BOOTS L R,et al.Prevalence of polycystic ovary syndrome (PCOS) in first-degree relatives of patients with PCOS[J]. Fertil Steril, 2001, 75(1): 53-58.
BARKER D J.Fetal programming of coronary heart disease[J]. Trends Endocrinol Metab, 2002, 13(9): 364-368.
KOIVUAHO E,LARU J,OJANIEMI M,et al.Age at adiposity rebound in childhood is associated with PCOS diagnosis and obesity in adulthood-longitudinal analysis of BMI data from birth to age 46 in cases of PCOS[J]. Int J Obes (Lond), 2019, 43(7): 1370-1379.
IBÁÑEZ L,ONG K K,LÓPEZ-BERMEJO A,et al.Hyperinsulinaemic androgen excess in adolescent girls[J]. Nat Rev Endocrinol, 2014, 10(8): 499-508.
DE ZEGHER F,LÓPEZ-BERMEJO A,IBÁÑEZ L.Central obesity, faster maturation, and “PCOS” in girls[J]. Trends Endocrinol Metab, 2018, 29(12): 815-818.
DE ZEGHER F,REINEHR T,MALPIQUE R,et al.Reduced prenatal weight gain and/or augmented postnatal weight gain precedes polycystic ovary syndrome in adolescent girls[J].Obesity (Silver Spring), 2017, 25(9): 1486-1489.
DAVIES M J,MARCH W A,WILLSON K J,et al.Birthweight and thinness at birth independently predict symptoms of polycystic ovary syndrome in adulthood[J]. Hum Reprod, 2012, 27(5): 1475-1480.
DUMESIC D A,HOYOS L R,CHAZENBALK G D,et al.Mechanisms of intergenerational transmission of polycystic ovary syndrome[J]. Reproduction, 2020, 159(1): R1-R13.
ROLAND A V,NUNEMAKER C S,KELLER S R,et al.Prenatal androgen exposure programs metabolic dysfunction in female mice[J]. J Endocrinol, 2010, 207(2): 213-223.
XU N,KWON S,ABBOTT D H,et al.Epigenetic mechanism underlying the development of polycystic ovary syndrome (PCOS)-like phenotypes in prenatally androgenized rhesus monkeys[J]. PLoS One, 2011, 6(11): e27286.
ABRUZZESE G A,FERREIRA S R,FERRER M J,et al.Prenatal androgen excess induces multigenerational effects on female and male descendants[J]. Clin Med Insights Endocrinol Diabetes, 2023, 16: 11795514231196461.
PORTER D T,MOORE A M,COBERN J A, et al.Prenatal testosterone exposure alters GABAergic synaptic inputs to GnRH and KNDy neurons in a sheep model of polycystic ovarian syndrome[J].Endocrinology, 2019, 160(11): 2529-2542.
TATA B,MIMOUNI N E H,BARBOTIN A L,et al.Elevated prenatal anti-Müllerian hormone reprograms the fetus and induces polycystic ovary syndrome in adulthood[J]. Nat Med, 2018, 24(6): 834-846.
MIMOUNI N E H,PAIVA I,BARBOTIN A L,et al.Polycystic ovary syndrome is transmitted via a transgenerational epigenetic process[J].Cell Metab, 2021, 33(3): 513-530.
HO E V,SHI C,CASSIN J,et al.Reproductive deficits induced by prenatal antimüllerian hormone exposure require androgen receptor in kisspeptin cells[J]. Endocrinology, 2021, 162(12): bqab197.
GUO X,PUTTABYATAPPA M,DOMINO S E,et al.Developmental programming: Prenatal testosterone-induced changes in epigenetic modulators and gene expression in metabolic tissues of female sheep[J]. Mol Cell Endocrinol, 2020, 514: 110913.
SINHA N,ROY S,HUANG B,et al.Developmental programming: prenatal testosterone-induced epigenetic modulation and its effect on gene expression in sheep ovary[J]. Biol Reprod, 2020, 102(5): 1045-1054.
PARKER J,O'BRIEN C,HAWRELAK J,et al.Polycystic ovary syndrome: An evolutionary adaptation to lifestyle and the environment[J]. Int J Environ Res Public Health, 2022, 19(3): 1336.
KAHN L G,PHILIPPAT C,NAKAYAMA S F,et al.Endocrine-disrupting chemicals: implications for human health[J]. Lancet Diabetes Endocrinol, 2020, 8(8): 703-718.
MITRO S D,JOHNSON T,ZOTA A R.Cumulative chemical exposures during pregnancy and early development[J]. Curr Environ Health Rep, 2015, 2(4): 367-378.
ROSENFELD C S.Transcriptomics and other omics approaches to investigate effects of xenobiotics on the placenta[J]. Front Cell Dev Biol, 2021, 9: 723656.
MANIKKAM M,TRACEY R,GUERRERO-BOSAGNA C,et al.Plastics derived endocrine disruptors (BPA, DEHP and DBP) induce epigenetic transgenerational inheritance of obesity, reproductive disease and sperm epimutations[J]. PLoS One, 2013, 8(1): e55387.
SMITH L M,CLOAK C C,POLAND R E,et al.Prenatal nicotine increases testosterone levels in the fetus and female offspring[J]. Nicotine Tob Res, 2003, 5(3): 369-374.
佚名.灵枢经[M].北京:人民卫生出版社, 2012: 67, 97.
ABBOTT D H,DUMESIC D A,FRANKS S.Developmental origin of polycystic ovary syndrome—a hypothesis[J]. J Endocrinol, 2002, 174(1): 1-5.
ABBOTT D H,ZHOU R,BIRD I M,et al.Fetal programming of adrenal androgen excess: lessons from a nonhuman primate model of polycystic ovary syndrome[J]. Endocr Dev, 2008, 13: 145-158.
DOUGLAS C C,NORRIS L E,OSTER R A,et al.Difference in dietary intake between women with polycystic ovary syndrome and healthy controls[J]. Fertil Steril, 2006, 86(2): 411-417.
DAMONE A L, JOHAM A E, LOXTON D,et al.Depression, anxiety and perceived stress in women with and without PCOS: a community-based study[J]. Psychol Med, 2019, 49(9): 1510-1520.