The role of interleukin‑1β in intervertebral disc degeneration and research progress of traditional Chinese medicine interventions

LIU Yandong; DENG Qiang; CHEN Bo; TAN Sheng; ZHANG Yanjun; LI Zhongfeng; PENG Randong

doi:10.16305/j.1007-1334.2024.2311142

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The role of interleukin‑1β in intervertebral disc degeneration and research progress of traditional Chinese medicine interventions

更新时间：2024-07-04

- The role of interleukin‑1β in intervertebral disc degeneration and research progress of traditional Chinese medicine interventions
- Shanghai Journal of Traditional Chinese Medicine Vol. 58, Issue 7, Pages: 95-100(2024)
- 作者机构：
  
  1.甘肃中医药大学（甘肃兰州 730000）
  2.甘肃省中医院（甘肃兰州 730050）
- 作者简介：
- 基金信息：
- DOI：10.16305/j.1007-1334.2024.2311142
  CLC：
- Published：10 July 2024，
  
  Received：27 November 2023，
- 稿件说明：
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刘晏东,邓强,陈博,等.白介素⁃1β在椎间盘退变中的作用及中药干预的研究进展[J].上海中医药杂志,2024,58(7):95-100.

LIU Yandong,DENG Qiang,CHEN Bo,et al.The role of interleukin‑1β in intervertebral disc degeneration and research progress of traditional Chinese medicine interventions[J].Shanghai Journal of Traditional Chinese Medicine,2024,58(7):95-100.
刘晏东,邓强,陈博,等.白介素⁃1β在椎间盘退变中的作用及中药干预的研究进展[J].上海中医药杂志,2024,58(7):95-100. DOI： 10.16305/j.1007-1334.2024.2311142.

LIU Yandong,DENG Qiang,CHEN Bo,et al.The role of interleukin‑1β in intervertebral disc degeneration and research progress of traditional Chinese medicine interventions[J].Shanghai Journal of Traditional Chinese Medicine,2024,58(7):95-100. DOI： 10.16305/j.1007-1334.2024.2311142.

摘要

综述白介素（IL）-1β在椎间盘退变中的作用及中药干预的研究进展。IL-1β是一种促炎性细胞因子，其过度分泌可导致椎间盘发生炎症和结构破坏，促使椎间盘退变进一步发展。近年来研究表明，中药活性成分可靶向抑制多种椎间盘细胞内的IL-1β，从而起到保护椎间盘的作用。基于IL-1β的结构、功能及调节机制，探讨IL-1β在椎间盘退变中的作用机制，并对相关中药的干预进展作一综述。

Abstract

This paper summarizes the role of interleukin-1β （IL-1β） in intervertebral disc degeneration and the advancement in research on interventions using traditional Chinese medicine （TCM）. IL-1β is a pro-inflammatory cytokine whose overexpression can lead to inflammation and structural damage in the intervertebral discs， further accelerating disc degeneration. Recent studies have shown that active components in traditional Chinese medicine can target and inhibit IL-1β within various disc cells， thereby protecting the discs. This paper discusses the mechanisms of IL-1β in intervertebral disc degeneration based on the structure， function， and regulatory mechanisms of IL-1β， and reviews the progress of related traditional Chinese medicine interventions.

关键词

椎间盘退变白介素-1β炎症作用中医药疗法研究进展

Keywords

intervertebral disc degenerationinterleukin-1βinflammatory effecttraditional Chinese medicine therapyresearch progress

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