Discussion on Chinese medicine research strategies of Alzheimer's disease based on theory of "turbid evils invading the clear orifice"

DING Minrui; ZHANG Mengxue; AN Hongmei

doi:10.16305/j.1007-1334.2024.2309114

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Discussion on Chinese medicine research strategies of Alzheimer's disease based on theory of "turbid evils invading the clear orifice"

更新时间：2024-11-07

- Discussion on Chinese medicine research strategies of Alzheimer's disease based on theory of "turbid evils invading the clear orifice"
- Shanghai Journal of Traditional Chinese Medicine Vol. 58, Issue 11, Pages: 58-63(2024)
- 作者机构：
  
  1.上海中医药大学附属龙华医院脑病科（上海 200032）
  2.上海中医药大学附属龙华医院科技处（上海 200032）
- 作者简介：
- 基金信息：
- DOI：10.16305/j.1007-1334.2024.2309114
  CLC：
- Published：10 November 2024，
  
  Received：21 September 2023，
- 稿件说明：
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丁敏芮,张梦雪,安红梅.基于“浊邪害清”理论探讨阿尔茨海默病中医药研究策略[J].上海中医药杂志,2024,58(11):58-63.

DING Minrui,ZHANG Mengxue,AN Hongmei.Discussion on Chinese medicine research strategies of Alzheimer's disease based on theory of "turbid evils invading the clear orifice"[J].Shanghai Journal of Traditional Chinese Medicine,2024,58(11):58-63.
丁敏芮,张梦雪,安红梅.基于“浊邪害清”理论探讨阿尔茨海默病中医药研究策略[J].上海中医药杂志,2024,58(11):58-63. DOI： 10.16305/j.1007-1334.2024.2309114.

DING Minrui,ZHANG Mengxue,AN Hongmei.Discussion on Chinese medicine research strategies of Alzheimer's disease based on theory of "turbid evils invading the clear orifice"[J].Shanghai Journal of Traditional Chinese Medicine,2024,58(11):58-63. DOI： 10.16305/j.1007-1334.2024.2309114.

摘要

基于“浊邪害清”理论探讨阿尔茨海默病中医药研究策略。认为“浊邪害清”为该病中后期病情加重的核心病机，提出肾精亏虚为发病之基，痰瘀浊邪阻窍为发病的关键环节。结合临床研究及中药药理研究，认为补虚祛浊为其基本治则，提出在补肾生髓的基础上，配伍化痰开窍、活血祛瘀等核心治法。

Abstract

The research strategy of traditional Chinese medicine in Alzheimer's disease（AD） is discussed based on the theory of "turbid evils invading the clear orifice". It is believed that "turbid evils invading the clear orifice" is the core mechanism for the aggravation of the disease in the middle and late stages. It is proposed that deficiency of kidney essence is the basis of pathogenesis， and phlegm and stasis evils obstruction of the orifice is the key link of pathogenesis. Combined with clinical research and Chinese medicine pharmacology research， it is believed that tonifying deficiency and dispelling turbidity is the basic rule of treatment， and it is proposed that on the basis of tonifying the kidney and generating the marrow， the core treatments such as resolving phlegm and opening orifice， activating blood circulation and dispelling blood stasis should be combined.

关键词

阿尔茨海默病浊邪害清病因病机中医药疗法

Keywords

Alzheimer's diseaseturbid evils invading the clear orificeetiology and pathogenesistraditional Chinese medicine therapy

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