JIN Xin,CHEN Qingguang,HOU Ruifang,et al.Mechanism and research progress of Atractylodis Rhizoma tonifying spleen and resolving dampness[J].Shanghai Journal of Traditional Chinese Medicine,2024,58(10):95-101.
JIN Xin,CHEN Qingguang,HOU Ruifang,et al.Mechanism and research progress of Atractylodis Rhizoma tonifying spleen and resolving dampness[J].Shanghai Journal of Traditional Chinese Medicine,2024,58(10):95-101. DOI: 10.16305/j.1007-1334.2024.2307022.
Mechanism and research progress of Atractylodis Rhizoma tonifying spleen and resolving dampness
Mechanism and research progress of Atractylodis Rhizoma tonifying spleen and resolving dampness is reviewed. Ancient physicians often used Atractylodis Rhizoma to treat various diseases related to spleen and stomach dampness. The components of Atractylodis Rhizoma can improve gastric emptying and small intestine propulsion rate, also can increase gastrin and motilin, and promote gastric acid secretion and enhance gastrointestinal motility. Moreover,it can decrease vasoative intestinal peptide levels and inhibit excessive intestinal peristalsis. Atractylodis Rhizoma can regulate gastrointestinal dysfunction in a bidirectional manner. It can improve abnormal morphology of gastric mucosa. It also can reduce gastric tissue injury and improve abnormal structure of intestinal tissue. The main effective component of Atractylodis Rhizoma in resolving dampness is volatile oil, which can lead to fluid loss, increased blood viscosity, affect salivary gland secretion, cause dry mouth, and decrease the expression of aquaporin 2 in the kidney. Atractylodis Rhizoma and its extracts can reduce the content of aquaporin in the stomach, colon, and urine of rats, regulating fluid metabolism in multiple organs. Therefore, Atractylodis Rhizoma achieves the effects of tonifying spleen and resolving dampness from various aspects such as organ morphology, gastrointestinal hormone level, and aquaporin expression.
关键词
苍术健脾燥湿脾虚湿阻证作用机制中药研究
Keywords
Atractylodis Rhizomatonifying spleenresolving dampnessspleen deficiency dampness obstruction syndromemechanism of actiontraditional Chinese herbal medicine research
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