Focusing on emotional pathogenesis theory of traditional Chinese medicine: advantages and prospects of traditional Chinese medicine in regulating emotional stress to prevent recurrence and metastasis of malignant tumors
|更新时间:2023-06-16
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Focusing on emotional pathogenesis theory of traditional Chinese medicine: advantages and prospects of traditional Chinese medicine in regulating emotional stress to prevent recurrence and metastasis of malignant tumors
Shanghai Journal of Traditional Chinese MedicineVol. 57, Issue 6, Pages: 1-5(2023)
ZHANG Zhaozhou,WANG Yan.Focusing on emotional pathogenesis theory of traditional Chinese medicine: advantages and prospects of traditional Chinese medicine in regulating emotional stress to prevent recurrence and metastasis of malignant tumors[J].Shanghai Journal of Traditional Chinese Medicine,2023,57(6):1-5.
ZHANG Zhaozhou,WANG Yan.Focusing on emotional pathogenesis theory of traditional Chinese medicine: advantages and prospects of traditional Chinese medicine in regulating emotional stress to prevent recurrence and metastasis of malignant tumors[J].Shanghai Journal of Traditional Chinese Medicine,2023,57(6):1-5. DOI: 10.16305/j.1007-1334.2023.2304014.
Focusing on emotional pathogenesis theory of traditional Chinese medicine: advantages and prospects of traditional Chinese medicine in regulating emotional stress to prevent recurrence and metastasis of malignant tumors
Emotional stress can stimulate the invasion and metastasis of malignant tumors through various ways. Traditional Chinese medicine (TCM) has accumulated rich clinical experience in preventing and treating emotional diseases, and has formed a complete and unique theoretical system. The advantages of TCM in regulating emotional stress to prevent and treat recurrence and metastasis of malignant tumors are analyzed based on a systematic review, and intervention strategies for emotional stress in patients with malignant tumors are proposed in this paper, aiming to provide reference for further research related to the integrative medicine prevention and treatment of the recurrence and metastasis of malignant tumors.
关键词
癌症情志应激心理应激肿瘤相关抑郁复发转移中医药疗法经典名方
Keywords
canceremotional stresspsychological stresscancer-related depressionrecurrence and metastasistraditional Chinese medicine therapyclassical formula
TIAN D, TIAN M, HAN G, et al. Increased glucocorticoid receptor activity and proliferation in metastatic colon cancer[J]. Sci Rep, 2019, 9(1): 11257.
ZHANG Y J, SHI G, ZHANG H T, et al. Dexamethasone enhances the lung metastasis of breast cancer via a PI3K-SGK1-CTGF pathway[J]. Oncogene, 2021, 40(35): 5367-5378.
CUI B, LUO Y Y, TIAN P F, et al. Stress-induced epinephrine enhances lactate dehydrogenase A and promotes breast cancer stem-like cells[J]. J Clin Invest, 2019, 129(3): 1030-1046.
JEONG J H, PARK H J, PARK S H, et al. β2-adrenergic receptor signaling pathway stimulates the migration and invasion of cancer cells via src activation[J]. Molecules, 2022, 27(18): 5940.
HAN J, JIANG Q Y, MA R L, et al. Norepinephrine-CREB1-miR-373 axis promotes progression of colon cancer[J]. Mol Oncol, 2020, 14(5): 1059-1073.
TIAN W T, LIU Y, CAO C H, et al. Chronic Stress: Impacts on Tumor Microenvironment and Implications for Anti-Cancer Treatments[J]. Front Cell Dev Biol, 2021, 9: 777018.
SILVIA C, MAREN C, CARSTEN W. Regulation of natural killer cell activity by glucocorticoids, serotonin, dopamine, and epinephrine[J]. Cell Mol Immunol, 2020, 17(7): 705-711.
ANTONI M H, DHABHAR F S. The impact of psychosocial stress and stress management on immune responses in patients with cancer[J]. Cancer, 2019, 125(9): 1417-1431.
BI Z R, LI W, ZHAO J, et al. Negative correlations of psychological distress with quality of life and immunotherapy efficacy in patients with advanced NSCLC[J]. Am J Cancer Res, 2022, 12(2): 805-815.
PU J, BAI D N, YANG X, et al. Adrenaline promotes cell proliferation and increases chemoresistance in colon cancer HT29 cells through induction of miR-155[J]. Biochem Biophys Res Commun, 2012, 428(2): 210-215.
NILSSON M B, SUN H Y, DIAO L X, et al. Stress hormones promote EGFR inhibitor resistance in NSCLC: Implications for combinations with β-blockers[J]. Sci Transl Med, 2017, 9 (415): eaao4307.
LI N N, WANG Q, WANG Y, et al. Fecal microbiota transplantation from chronic unpredictable mild stress mice donors affects anxiety-like and depression-like behavior in recipient mice via the gut microbiota-inflammation-brain axis[J]. Stress, 2019, 22(5): 592-602.
ZHANG B H, DONG W W, MA Z X, et al. Hyperbaric oxygen improves depression-like behaviors in chronic stress model mice by remodeling gut microbiota and regulating host metabolism[J]. CNS Neurosci Ther, 2023, 29(1): 239-255.
LI R, ZHOU R, WANG H, et al. Gut microbiota-stimulated cathepsin K secretion mediates TLR4-dependent M2 macrophage polarization and promotes tumor metastasis in colorectal cancer[J]. Cell Death Differ, 2019, 26(11): 2447-2463.
ZHANG Z Z, WANG Y, LI Q. Mechanisms underlying the effects of stress on tumorigenesis and metastasis (Review)[J]. Int J Oncol, 2018, 53(6): 2332-2342.
SHAO S Y, ZHANG Z Z, ZHANG Y R, et al. A method to establish a chronic restraint stress mouse model with colorectal cancer xenografts[J]. MethodsX, 2021, 8: 101304.
ZHANG Z Z, SHAO S Y, ZHANG Y R, et al. Xiaoyaosan slows cancer progression and ameliorates gut dysbiosis in mice with chronic restraint stress and colorectal cancer xenografts[J]. Biomed Pharmacother, 2020, 132: 110916.
SHAO S Y, JIA R, ZHAO L, et al. Xiao-Chai-Hu-Tang ameliorates tumor growth in cancer comorbid depressive symptoms via modulating gut microbiota-mediated TLR4/MyD88/NF-κB signaling pathway[J]. Phytomedicine, 2021, 88: 153606.
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