Objective,2,To explore the distribution rule of traditional Chinese medicine （TCM） syndrome elements in chronic obstructive pulmonary disease （COPD） with lung cancer.,Methods,2,Referring to relevant literature and clinical experience， the TCM symptoms and signs that can reflect the clinical characteristics of COPD and lung cancer were selected and a survey scale was developed. On this basis， baseline data and TCM four diagnosis information of COPD （without lung cancer）， lung cancer （without COPD）， and COPD with lung cancer （respectively set as COPD group， lung cancer group， and COPD with lung cancer group） were collected and entered into “iLUNG TCM” health management software system. The TCM syndrome elements distribution in each group of patients were analyzed and compared based on the syndrome elements differentiation system. The TCM syndrome elements combination rule was explored using hierarchical cluster analysis method.,Results,2,①A total of 527 subjects were collected， including 166 patients in the COPD group， 182 patients in the lung cancer group， and 179 patients in the COPD with lung cancer group. ②Among 179 patients in the COPD with lung cancer group， more than one-third had phlegm（134 cases）， qi deficiency （123 cases）， and blood stasis （75 cases） in terms of TCM syndrome elements of the disease nature category. The COPD with lung cancer group had higher proportion of patients with phlegm and blood stasis and lower proportion of patients with qi stagnation than the COPD group （,P,<,0.05）； Meanwhile， the COPD with lung cancer group had higher proportion of patients with phlegm and lower proportion of patients with yin deficiency than the lung cancer group （,P,<,0.05）. ③Among 179 patients in the COPD with lung cancer group， more than half of the patients had their disease locations involving the lung （179 cases）， kidney （121 cases）， and spleen （94 cases） in terms of the TCM syndrome elements of disease location category. The COPD with lung cancer group had higher proportion of kidney involvement in patients than the lung cancer group （,P,<,0.05）. ④The COPD with lung cancer group had higher proportion of patients with more than 3 syndrome elements than the COPD group and the lung cancer group （,P,<,0.05）. ⑤The result of cluster analysis showed that the syndrome elements of the disease nature category in COPD with lung cancer could be divided into three categories： the first category included phlegm and blood stasis， the second category included qi deficiency and yang deficiency， and the third category included yin deficiency， dampness， heat， blood deficiency， qi stagnation and cold.,Conclusions,2,The disease location of COPD with lung cancer is mainly in lung， kidney and spleen. The phlegm， blood stasis， qi deficiency and yang deficiency are the most common TCM syndrome elements in patients with COPD and lung cancer， with the pathogenic characteristics of vital qi deficiency， intermingled phlegm and blood stasis， and intermingled deficiency and excess.